Acyclic Carbon To Carbon Unsaturation Patents (Class 514/701)
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Publication number: 20090099061Abstract: A method is described for synthesizing and administering carotenoid compounds with improved antioxidant characteristics. In some embodiments, extension or improvement of conjugation may be employed in structural modification of carotenoids. In other embodiments, reduction of ring/chain steric hindrance may improve the lambda max, and hence, the overall antioxidant capability, of particular compounds. In other embodiments, introduction and/or increase in synthetic handles for conjugation may improve the stoichiometric ratios of conjugating moieties to the polyene backbone. The methods may be used to improve natural and/or synthetic compounds for medicinal application in the treatment of disease.Type: ApplicationFiled: May 13, 2008Publication date: April 16, 2009Inventors: Bente J. Foss, Geoffry T. Nadolski, Samuel F. Lockwood
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Publication number: 20090036413Abstract: Rationally designed wound care products made entirely of naturally occurring food ingredients that can be standardized and made available for the mass market using good manufacturing practice (GMP) guidelines, optionally, a safe food additive can be added. These products: are safe and effective; have an osmotic pressure compatible with optimal healing; are buffered to maintain optimal pH throughout the healing process; provide a protective barrier from further irritation and insult; control bacteria, viruses and fungi found in the skin and mucosa; nourish wounds; control excessive prolonged inflammation and thereby minimize scarring; minimize allergenic and irritation potential; are easy to use or apply; pass the preservative challenge test required for products intended for multiple use; contain fragrant essential oils to take advantage of the benefits provided by aromatherapy; can be individually optimized based on the diet of an individual or group of people.Type: ApplicationFiled: July 29, 2008Publication date: February 5, 2009Applicant: Bill McAnalleyInventors: Shayne McAnalley, Bill McAnalley, Erik Aguayo
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Publication number: 20090017123Abstract: An object of the present invention is to provide a novel dermal regeneration enhancer. In accordance with the present invention, there is provided a dermal regeneration enhancer as a novel pharmaceutical use of lyotropic liquid crystal which has been utilized as a basic material for pharmaceutical preparations for external application and for cosmetics, and the dermal regeneration enhancer of the present invention achieves an excellent suppressive effect to aging of the skin, generation of spots, etc.Type: ApplicationFiled: April 28, 2006Publication date: January 15, 2009Applicants: JAPAN SCIENCE AND TECHNOLOGY AGENCY, NANOEGG RESEARCH LABORATORIES, INC.Inventors: Yoko Yamaguchi, Rie Igarashi
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Publication number: 20080312337Abstract: Disclosed herein is an anticancer composition, comprising obovatol, represented by the following Chemical Formula 1, obovatal, represented by the following Chemical Formula 2, and/or pharmaceutical salts thereof. The composition exhibits the activity of inhibiting the growth of cancer cells and suppressing the expression and activity of matrix metalloproteinases (MMPs), and thus can be useful for the prophylaxis and treatment of cancer as well as for the inhibition of cancer metastasis.Type: ApplicationFiled: August 19, 2008Publication date: December 18, 2008Applicant: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGYInventors: Byoung-Mog KWON, Kwang-Hee SON, Dong-Cho HAN, Su-Kyung LEE, Jung-Min KIM, Young-Hee KHO, Hyo-Kon CHUN, Jae-Young YANG
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Publication number: 20080300318Abstract: The invention generally relates to various cinnamaldehyde (cinnamic aldehyde) formulations for protecting plants from nematodes and other pathogens. The invention provides specific formulations which do not require the use of chemical additives. These formulations have low phytotoxicity and low volatility. Also, methods of applying the formulations for agricultural use are disclosed.Type: ApplicationFiled: May 16, 2008Publication date: December 4, 2008Inventors: Yueh Wang, Bassam Shammo, Rebecca Dickenson, John Lopez, Judith Fugiel, Linda Rehberger, Prem Warrior
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Publication number: 20080220103Abstract: Provided is a method of treating a fungal infection on an animal epidermis, nail or hair, or in an orifice of an animal. The method comprises contacting the fungus infection with a composition comprising an antifungal botanical.Type: ApplicationFiled: March 13, 2008Publication date: September 11, 2008Inventors: Jay Birnbaum, Thomas Blake, Mahmoud Ghannoum, Steven Vallespir
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Publication number: 20080132569Abstract: The present invention is related to an antifungal composition for inhibition of wood decay caused by wood rot fungi. The invention further comprises a method for inhibition of wood decay with gallates.Type: ApplicationFiled: November 21, 2007Publication date: June 5, 2008Applicant: NATIONAL TAIWAN UNIVERSITYInventors: Shang-Tzen Chang, Fu-Lan Hsu, Hui-Ting Chang, Tsair-Bor Yen
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Publication number: 20070207981Abstract: Systems are provided for preventing post harvest fungal diseases of food systems, such as but not limited to fresh produce, such as but not limited to berries (e.g., blueberries). For example, various anti-fungal compounds can incorporated or encapsulated into cyclodextrins, such as but not limited to ?, ? and/or ? cyclodextrins. The encapsulated anti-fungal materials can be used alone (e.g., brought into proximity to the produce) or incorporated into film and/or packaging materials that are used in the packing and/or storing of produce. By way of a non-limiting example, the anti-fungal compounds can include volatile compounds such as but not limited to acetaldehyde, hexanal and 2E-hexenal. The cyclodextrins provide controlled release of the volatiles over a period of at least several days such that they prevent or inhibit fungal growth, including but not limited to several species of the Colletotrichum, Altermaria, Botrytis, Penicillium and/or Aspergillus genera.Type: ApplicationFiled: March 6, 2007Publication date: September 6, 2007Inventors: Eva Almenar, Rafael Auras, Bruce Harte, Maria Rubino
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Patent number: 6984389Abstract: The present invention relates to methods of improving a treatment outcome comprising administering a heat shock protein (HSP) preparation or an ?-2-macroglobulin (?2M) preparation with a non-vaccine treatment modality. In particular, an HSP preparation or an ?2M preparation is administered in conjunction with a non-vaccine treatment modality for the treatment of cancer or infectious diseases. In the practice of the invention, a preparation comprising HSPs such as but not limited to, hsp70, hsp90 and gp96 alone or in combination with each other, noncovalently or covalently bound to antigenic molecules or ?2M, noncovalently or covalently bound to antigenic molecules is administered in conjunction with a non-vaccine treatment modality.Type: GrantFiled: December 16, 2002Date of Patent: January 10, 2006Assignee: University of Connecticut Health CenterInventor: Zihai Li
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Publication number: 20040254196Abstract: The present invention relates to cinnamaldehyde derivatives inhibiting growth of tumor cell and regulating cell cycle, the method for preparation and the pharmaceutical composition thereof. The cinnamaldehyde derivatives of the present invention can be effectively used as a cell cycle regulator or a cancer cell growth inhibitor, since it has an ability to regulate cell cycle by holding the cells in G2/M stage of the cell division and has activity to inhibit cancer cell growth.Type: ApplicationFiled: May 28, 2004Publication date: December 16, 2004Inventors: Byoung-Mog Kwon, Kwang-Hee Son, Dong Cho Han, Sangku Lee, Jong Han Kim, Sung-Gyu Choi, Mi-Young Lee, Sun Bok Jeon
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Publication number: 20040209962Abstract: Methods and compositions based upon natural aromatic aldehydes are provided, which find use as pesticides. The pesticides are formulated in a variety of ways, including dusts, sprays, shampoos and soaps, and can be bound to a solid support or provided as bait or directly impregnated into organic matter infested by or susceptible to infestation by a target pest. Pests controlled include mosquitoes, lice, ants, cockroaches, lice, and ticks.Type: ApplicationFiled: January 14, 2004Publication date: October 21, 2004Applicant: ProGuard, Inc.Inventors: Bradford G. Crandall, Ralph W. Emerson
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Patent number: 6800659Abstract: Novel styrylacrylonitrile compounds which are useful in treating a variety of cell proliferative disorders such as cancer are disclosed.Type: GrantFiled: April 12, 2001Date of Patent: October 5, 2004Assignee: HSC Research and Development Limited PartnershipInventors: Chaim M. Roifman, Thomas Grunberger, Olga Rounova, Demin Peter, Nigel Sharfe
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Patent number: 6750256Abstract: Methods and compositions based upon natural aromatic aldehydes are provided, which find use as pesticides. The pesticides are formulated in a variety of ways, including dusts, sprays, shampoos and soaps, and can be bound to a solid support or provided as bait or directly impregnated into organic matter infested by or susceptible to infestation by a target pest. Pests controlled include mosquitos, lice, ants, cockroaches, lice, and ticks.Type: GrantFiled: October 29, 1999Date of Patent: June 15, 2004Assignee: Proguard, Inc.Inventors: Bradford G. Crandall, Jr., Ralph W. Emerson
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Publication number: 20040086546Abstract: A pullulan-free edible film composition for oral cleansing, breath freshening, and anti-microbial benefits includes a film forming agent and cinnamaldehyde. In a treatment process, effective amounts of cinnamaldehyde is delivered to the oral cavity by the edible film for convenient oral cleansing and breath freshening benefits. A method of making the pullulan-free edible film composition includes forming an aqueous solution of film forming agents and cinnamaldehyde and drying the aqueous solution to form a dry edible film.Type: ApplicationFiled: June 25, 2003Publication date: May 6, 2004Inventors: James Roy Maxwell, Michael J. Greenberg
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Publication number: 20030091661Abstract: Pesticidal compositions for the control of beetles in stored food products containing one or more plant essential oils. In addition, the present invention is directed to a method for controlling beetles from accessing stored food products by applying a pesticidally-effective amount of the above pesticidal compositions to a locus where pest control is desired.Type: ApplicationFiled: December 13, 2002Publication date: May 15, 2003Applicant: EcoSMART Technologies, Inc.Inventor: Steven M. Bessette
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Publication number: 20030005484Abstract: Methods and compositions based upon natural compounds, including balsam, cinnamic aldehyde, a-hexyl cinnamic aldehyde, and coniferyl aldehyde are provided, which find use as pesticides. The compositions are effective against pathogenic fungi, arachnids and insects at concentrations which are not phytotoxic to the treated host plant. Infestations of a variety of plant parts can be treated, including those of leaves, seeds, seedlings, fruit, flowers and roots. Susceptible organisms include rust, powdery mildew, botrytis, phylloxera, aphids, thrips, codling moth, nematodes and leaf hoppers.Type: ApplicationFiled: April 5, 2002Publication date: January 2, 2003Applicant: ProGuard, Inc.Inventors: Bradford G. Crandall, Ralph W. Emerson
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Publication number: 20020099101Abstract: Methods and compositions based upon natural flavonoid aldehydes, including cinnamic aldehyde, &agr;-hexyl cinnamic aldehyde, and coniferyl aldehyde are provided, which find use as pesticides. The compositions are effective against pathogenic fungi, arachnids and insects at concentrations which are not phytotoxic to the treated host plant. Infestations of a variety of plant parts can be treated, including those of leaves, seeds, seedlings, fruit, flowers and roots. Susceptible organisms include rust, powdery mildew, botrytis, phylloxera, aphids, thrips, codling moth, nematodes and leaf hoppers.Type: ApplicationFiled: May 25, 2001Publication date: July 25, 2002Applicant: ProGuard, Inc.Inventors: Ralph W. Emerson, Bradford G. Crandall
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Publication number: 20020002139Abstract: The invention provides a method of modulating the immune system. Also provided is a method of treating a pathology associated with increased levels of a tumor necrosis factor. The invention further provides a method of treating a pathology resulting from infection by human immunodeficiency virus. Also provided is a method of treating chronic graft vs. host disease. Finally, the invention provides a method of promoting wound healing in a subject.Type: ApplicationFiled: December 4, 2000Publication date: January 3, 2002Applicant: Omega Pharmaceutical, Inc.Inventors: Thomas W. Hodge, David W. Boykin
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Patent number: 6251951Abstract: Methods and compositions based upon natural flavonoid and aromatic aldehydes are provided, which find use as pesticides. The compositions are effective against pathogenic fungi and insects at concentrations which are not phytotoxic to the treated host plant. Infestations of a variety of plant parts can be treated, including those of leaves and roots. Susceptible organisms include rust, powdery mildew and aphids.Type: GrantFiled: June 7, 1995Date of Patent: June 26, 2001Assignee: Proguard, IncInventors: Ralph W. Emerson, Bradford G. Crandall, Jr.
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Patent number: 6074634Abstract: The present invention provides an composition for attracting noctuid and/or other lepidopteran species. Liquid and solid formulations are provided, along with methods for their use, for controlling or eliminating noctuid and/or other lepidopteran species, and/or protecting plants susceptible to noctuid and/or other lepidopteran species damage.Type: GrantFiled: October 5, 1998Date of Patent: June 13, 2000Assignee: The United States of America as represented by the Secretary of AgricultureInventors: Juan D. Lopez, Jr., Ted N. Shaver, Kenneth R. Beerwinkle, Peter D. Lingren
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Patent number: 6020382Abstract: The instant invention is concerned with acetylphenols which are useful as antiobesity and antidiabetic compounds. Compositions and methods for the use of the compounds in the treatment of diabetes and obesity and for lowering or modulating triglyceride levels and cholesterol levels or raising high density lipoprotein levels or for increasing gut motility or for treating atherosclerosis are also disclosed.Type: GrantFiled: January 4, 1999Date of Patent: February 1, 2000Assignee: Merck & Co., Inc.Inventors: Thomas W. Doebber, Joel P. Berger, Gregory D. Berger, Mark D. Leibowitz, David E. Moller, John T. Olson, Arthur A. Patchett, Richard B. Toupence
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Patent number: 5861385Abstract: Substituted triols are prepared by reducing appropriately substituted carboxylic esters. The substituted triols can be used as active substances in medicaments.Type: GrantFiled: August 8, 1995Date of Patent: January 19, 1999Assignee: Bayer AktiengesellschaftInventors: Rolf Angerbauer, Peter Fey, Walter Hubsch, Thomas Philipps, deceased, Hilmar Bischoff, Hans-Peter Krause, Jorg Petersen von Gehr, Delf Schmidt
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Patent number: 5843375Abstract: The present invention provides methods and compositions for inhibiting microbial growth through the use of aromatic aldehydes or alcohols for the purpose of disinfecting contaminated environments. The methods include the step of contacting the unsterile area with an amount of a aromatic aldehyde or alcohol sufficient to control growth of pathogenic microbes. The aldehyde or alcohol can be provided in a variety of formulations.Type: GrantFiled: June 7, 1995Date of Patent: December 1, 1998Assignee: Proguard, Inc.Inventors: Ralph W. Emerson, Bradford G. Crandall, Jr.
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Patent number: 5839224Abstract: Methods and compositions based upon natural aromatic compounds are provided, which find use as pesticides. The pesticides are formulated in a variety of ways, including dusts, sprays, shampoos and soaps, and can be bound to a solid support or provided as bait or directly impregnated into organic matter infested by or susceptible to infestation by a target pest. Pests controlled include mosquitos, lice, ants, cockroaches, lice, and ticks.Type: GrantFiled: March 25, 1996Date of Patent: November 24, 1998Assignee: Proguard, Inc.Inventors: Ralph W. Emerson, Bradford G. Crandall, Jr.
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Patent number: 5792467Abstract: Repellent compositions which contain aromatic aldehydes such as cinnamic aldehyde, .alpha.-hexyl cinnamic aldehyde and/or coniferyl aldehyde are provided, together with methods for their use as repellents for pests including flies, cockroaches, aphids, silverleaf white flies, mosquitoes, ticks, fleas, lice, leafhoppers, thrips, two-spotted spider mites, snails, slugs, biting midges, earwigs, and moths. Also provided are stabilized .alpha.-hexylcinnamic aldehyde (HCA) compositions which reduce the evaporation rate of HCA and/or induce HCA to evaporate at a constant rate over time.Type: GrantFiled: December 24, 1996Date of Patent: August 11, 1998Assignee: Proguard, Inc.Inventors: Ralph W. Emerson, Bradford G. Crandall, Jr.
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Patent number: 5738861Abstract: The present invention provides methods and compositions for inhibiting microbial growth through the use of flavonoid aldehydes or alcohols for the purpose of disinfecting contaminated environments. The methods include the step of contacting the unsterile area with an amount of a flavonoid aldehyde or alcohol sufficient to control growth of pathogenic microbes. The aldehyde or alcohol can be provided in a variety of formulations.Type: GrantFiled: November 22, 1995Date of Patent: April 14, 1998Assignee: Proguard, Inc.Inventors: Ralph W. Emerson, Bradford G. Crandall, Jr.
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Patent number: 5693344Abstract: A hazard-free method for controlling insects using a non-toxic composition. The invention includes a process for making the composition in the form of a fragrance and crystalline particles which puncture directly through the exoskeleton of an insect. In operation, the particles work themselves between the insect's protective body plates and then puncture the exoskeleton permitting entry of the fragrance into the body of the insect. Once inside, the particles absorb up to four times their weight of the vital body fluids of the insect and the fragrance has a neural effect on the insect.Type: GrantFiled: November 9, 1995Date of Patent: December 2, 1997Assignee: Ecosmart, Inc.Inventors: Arthur Michael Knight, Steven M. Bessette
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Patent number: 5639459Abstract: The invention provides a composition for the treatment for the hair, scalp and skin to improve condition and to assist in hair regrowth which comprises a pharmaceutically acceptable oxalate of a group Ia or Ia or ammonium oxalate metal disposed in a pharmaceutically acceptable carrier of diluent therefor. Preferably, the group IIa metal is calcium and the pharmaceutically acceptable carrier or diluent is an ointment.Type: GrantFiled: July 6, 1995Date of Patent: June 17, 1997Inventor: Elias Bouras
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Patent number: 5496858Abstract: Aqueous disinfectant concentrate which includes succinic dialdehyde, glutaraldehyde and/or formaldehyde, one or more alcohols of limited water miscibility and optionally usual auxiliaries. By diluting with water, a working solution can be prepared from the concentrate. The advantages of the new disinfectant concentrate or disinfectant are the reduced development of odor, an improved material compatibility, an improved microbicidal effectiveness and a clearly increased storage-stability. Furthermore, the activation usual up until now with disinfectants based on aldehyde is superfluous. Preferred application fields are surface and instrument disinfection.Type: GrantFiled: January 11, 1994Date of Patent: March 5, 1996Assignee: Reckitt & Colman Inc.Inventors: Heinz Eggensperger, Bernd Lower, Michael Mohr, Peter Goroncy-Bermes, Rolf Kleinwort
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Patent number: 5486537Abstract: An antifungal composition which can be topically applied to skin and keratinous tissue and is active against the fungi Trichophyton mentagrophytes and Candida albicans includes griseofulvin dissolved in a solvent blend of cinnamic aldehyde and alcohol, particularly isopropanol. Topical antifungal compositions of cinnamic aldehyde in isopropyl alcohol are also provided. Packaged products are provided and include the compositions disposed in sealed containers. A method is also provided for treating keratinous tissue infected with the fungi.Type: GrantFiled: January 20, 1995Date of Patent: January 23, 1996Assignee: Dayton Laboratories, Inc.Inventor: Reynaldo G. Farinas
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Patent number: 5250573Abstract: A sterilising composition of antibacterial and antimycotic activity possessing considerable stability with time, comprising glutaraldehyde, an alkyl-, aryl- or halogen-substituted phenol, a non-ionic surface-active agent and preferably an alkanol of 2-5 carbon atoms, in an aqueous vehicle, at a pH of between 3.5 and 5.5.Type: GrantFiled: November 9, 1988Date of Patent: October 5, 1993Assignee: Germo S.p.A.Inventor: Luigi F. Magni
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Patent number: 5149715Abstract: A method of controlling toxic fungal diseases in mushrooms is provided which comprises adding an effective fungal-disease-inhibiting amount of a compound of the formula ##STR1## to a substrate in which mushrooms are growing or are to be grown, wherein R represents --CH.sub.2 OH or --CHO; n is an integer from 0 to 3; and each R.sup.1 independently represents halogen, OH, NH.sub.2, or an organic substituent containing from 1 to 10 carbon atoms and from 0 to 5 heteroatoms, wherein the total number of carbon and heteroatoms in all R.sup.1 substituents is no more than 15.Type: GrantFiled: February 9, 1989Date of Patent: September 22, 1992Assignee: Monterey Mushroom, Inc.Inventors: Gale L. Armstrong, Nigel S. Dunn-Coleman, Mark Wach
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Patent number: 5124354Abstract: A composition suitable for topical application to mammalian skin or hair for inducing, maintaining or increasing hair growth comprises:(i) a special protein tyrosine kinase inhibitor; and(ii) a cosmetically acceptable vehicle for the inhibitor.Type: GrantFiled: June 11, 1990Date of Patent: June 23, 1992Assignee: Chesebrough Pond's USA Co., Division of Conopco, Inc.Inventor: Martin R. Green
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Patent number: 5093360Abstract: Therapeutic as well as preventive measures to improve cosmetic conditions and to alleviate the symptoms of dermatologic disorders with retinal and its derivatives is disclosed. Cosmetic conditions and dermatologic disorders in humans and domestic animals in which retinal and its derivatives may be useful include age spots, wrinkles, warts, eczema, seborrheic keratoses, acne, oily skin, psoriasis, dandruff, xerosis, inflammatory and pruritic skin, disturbed keratinization skin changes associated with aging and possibly viral infections. Retinal and its derivatives include their stereoisomers, for example, all-trans, 13-cis, 11-cis, 9-cis, 7-cis, 11,13-cis and 9,13-cis vitamin A aldehydes, their hydrate, hemiacetal and acetal forms, and their adduct compounds. Compositions containing retinal or its derivative may be administered systemically such as orally, or topically to the affected areas of the skin.Type: GrantFiled: April 7, 1989Date of Patent: March 3, 1992Inventors: Ruey J. Yu, Eugene J. Van Scott
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Patent number: 4978686Abstract: Crops can effectively be protected from the attack of insect pests, microorganisms and pathogenic microbes by spraying thereon a non-toxic and stable composition comprising cinnamic aldehyde and an antioxidant in the form of an emulsion or powder.Type: GrantFiled: January 24, 1990Date of Patent: December 18, 1990Inventor: Kiyoshi Sotome
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Patent number: 4946865Abstract: A compound of the formula: ##STR1## wherein X is a hydrogen atom, a halogen atom, a C.sub.1 -C.sub.3 alkyl group or a C.sub.1 -C.sub.3 alkoxy group and Y is a hydrogen atom, a halogen atom, a cyano group, a formyl group, an ethylene-dioxymethyl group, a hydroxyl group, a hydroxymethyl group or a group of either one of the formulas: --CH.dbd.N--OR.sup.1, --COOR.sup.2, --CONH--R.sup.2 and --CH(OR.sup.3).sub.2 in which R.sup.1 is a hydrogen atom, a C.sub.1 -C.sub.3 alkyl group, a C.sub.3 -C.sub.5 alkenyl group, a C.sub.3 -C.sub.5 alkynyl group, a halo(C.sub.3 -C.sub.5)alkynyl group or a C.sub.1 -C.sub.3 alkyl group substituted with a phenyl group or a cyano group, R.sup.2 is a hydrogen atom, a C.sub.1 -C.sub.3 alkyl group, a C.sub.3 -C.sub.5 alkenyl group or a C.sub.3 -C.sub.5 alkynyl group and R.sup.3 is a C.sub.1 -C.sub.Type: GrantFiled: December 24, 1986Date of Patent: August 7, 1990Assignee: Sumitomo Chemical Company, LimitedInventors: Junya Takahashi, Shigeko Nakamura
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Patent number: 4826871Abstract: Topical ophthalmic compositions containing one or more retinoids selected from the group consisting of near and remote analogues and derivatives of retinoic acid are described. Six classes of ophthalmic vehicles suitable as carriers for the retinoids are also described. The compositions are useful in the treatment of dry eye syndrome and related ophthalmic surface disorders and as ocular lubricants. A method of treating dry eye syndrome and related ophthalmic surface disorders and a method of providing topical ocular lubrication using these compositions are also described.Type: GrantFiled: November 26, 1986Date of Patent: May 2, 1989Inventors: Philip D. Gressel, Robert E. Roehrs, John L. Ubels, Henry F. Edelhauser
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Patent number: 4801444Abstract: A medicinal preparation for individual prevention of venereal diseases and treatment of urogenital trichomoniasis comprises an efficient quantity of an active principle which is essentially a synergistic mixture of para-nitro-alpha-chlorocinnamic aldehyde of the formula: ##STR1## dimethylsulphoxide and a pharmaceutical excipient. Polyethyleneglycol having a molecular mass of 400 is recommended to be used as the pharmaceutical excipient.A method for treatment of urogenital trichomoniasis consists in application of the medicinal preparation in question to the mucosa of human genitalia in a dose of 1.5 to 10 ml twice a day for 5 to 7 days.Type: GrantFiled: March 3, 1988Date of Patent: January 31, 1989Assignee: Poltavsky Meditsinsky Stomatologichesky InstitutInventor: Vladimir G. Kravchenko
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Patent number: 4686235Abstract: Substituted cinnamyl-2,3-dihydrobenzofurans and analogs were prepared from the nucleophlic substitution of a cinnamylhalide with a 2,3-dihydrobenzofuran anion or an analog thereof. These compounds were found to be potent topical anti-inflammatory agents.Type: GrantFiled: August 12, 1985Date of Patent: August 11, 1987Assignee: Merck & Co., Inc.Inventors: Michael N. Chang, Norman P. Jensen, Milton L. Hammond, Robert A. Zambias, John McDonald, Kathleen M. Rupprecht
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Patent number: 4672395Abstract: The combination of an optical information recording and reproducing medium and a container for storing said optical information recording and reproducing medium, at least one of said optical information recording and reproducing medium and said container comprising a fungicide wherein said fungicide is in a layer selected from the group consisting of a layer comprising fine metal particles dispersed in a hydrophilic colloid dispersion medium; a layer comprising a metal or an alloy formed by a vacuum evaporation method or a sputtering method; and a layer comprising a coloring substance or consisting essentially of a polymeric substance. The invention also provides said medium when it contains a fungicide and a method for making the claimed combination and components thereof.Type: GrantFiled: September 30, 1985Date of Patent: June 9, 1987Assignee: Konishiroku Photo Industry Co., Ltd.Inventors: Kazuo Arai, Shinichi Nishi, Taxey Satoh, Yasushi Kawaguchi, Kiyomitsu Mine
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Patent number: 4650813Abstract: New hydroxybiphenyl compounds of the general formula: ##STR1## wherein R.sub.1 stands for a hydrogen atom or a hydroxyl group, R.sub.2 for a hydrogen atom or a hydroxyl group, R.sub.3 for a hydroxyl group, a group of the formula --CH.sub.2 --CH.dbd.CH.sub.2 or a group of the formula --CH.dbd.CH--CHO, R.sub.4 for a hydrogen atom or a group of the formula ##STR2## and R.sub.5 for a hydroxyl group or a group of the formula ##STR3## These compounds are obtained by extraction of "Tokoboku", i.e. dried cortex of Magnolia officinalis which belongs to the family Magnoliaceae. They are useful as pharmaceuticals or intermediates therefor, in particular as anti-allergics.Type: GrantFiled: March 6, 1985Date of Patent: March 17, 1987Assignee: Kabushiki Kaisha TsmurajuntendoInventors: Akihide Kooda, Itsuo Nishioka, Takeshi Nishiyori, Shoji Yahara
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Patent number: 4525480Abstract: A composition of matter comprised of cinnamaldehyde and one or more esters of p-hydroxybenzoic acid, commonly known as parabens, is disclosed. The composition exhibits synergistic activity against a wide range of microorganisms which contaminate ingestible products.Type: GrantFiled: June 10, 1983Date of Patent: June 25, 1985Assignee: Sutton Laboratories, Inc.Inventors: Philip A. Berke, William E. Rosen
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Patent number: RE39543Abstract: Methods and compositions based upon natural flavonoid aldehydes are provided, which find use as pesticides. The pesticides are formulated in a variety of ways, including dusts, sprays, shampoos and soaps, and can be bound to a solid support or provided as bait or directly impregnated into organic matter infested by or susceptible to infestation by a target pest.Type: GrantFiled: November 24, 1997Date of Patent: April 3, 2007Assignee: ProGuard, Inc.Inventors: Ralph W. Emerson, Bradford G. Crandall, Jr.