Acyclic Carbon To Carbon Unsaturation Patents (Class 514/720)
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Publication number: 20120028907Abstract: The disclosure relates to methods for identifying a tumor as an E2F-responsive gene over-expressing (ERGO) tumor, methods of determining the likelihood that an ERGO tumor patient will survive to a future date, methods of treating an ERGO tumor in a patient, and methods of selecting patients diagnosed as ERGO tumor prostate cancer patients for aggressive clinical treatment. The methods of the disclosure are applicable to ERGO tumors present in different human organs and tissues such as breast, lung, thyroid, ovary, and prostate.Type: ApplicationFiled: November 13, 2009Publication date: February 2, 2012Applicant: Intelligent Oncotherapeutics, Inc.Inventor: Stanley E. Shackney
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Patent number: 8080527Abstract: The invention provides compositions and methods for reducing one or more symptoms of an autoimmune disease, inflammatory disease, and/or transplant rejection, by the administration to a subject in need thereof a pharmaceutically effective amount of a purified compound of any one of Formulae A-E. The invention's methods are useful for the prevention, amelioration, and treatment of autoimmune disease, inflammatory disease, and/or transplant rejection.Type: GrantFiled: July 26, 2010Date of Patent: December 20, 2011Assignee: The Regents of the University of CaliforniaInventor: Michael David
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Patent number: 8039513Abstract: The present invention relates to cis-1,2-substituted stilbene derivatives, or their pharmaceutically acceptable salts, glucosides or solvates, a pharmaceutical composition comprising the compound, and use of said compound for preparation of a drug for treatment and/or prevention of diabetes or improvement of diabetic complications.Type: GrantFiled: July 20, 2005Date of Patent: October 18, 2011Assignee: Institute of Radiation Medicine, Academy of Military Medical Sciences, PLAInventors: Zhiyun Kang, Zuze Wu, Zhuangrong Sun, Zhongxiong Tang
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Publication number: 20110236448Abstract: A method for passively reducing nosocomial infections by providing fabrics for patient contact only as media for air filtration in areas with patient populations, which fabrics have been treated with a solution of eugenol of sufficient strength and for sufficient time to reduce the percentage of viable microbes in the fabrics by at least 2 log units.Type: ApplicationFiled: May 20, 2011Publication date: September 29, 2011Applicant: PHILADELPHIA UNIVERSITYInventors: Diana R. Cundell, Alexander A. Messinger, Brian R. George
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Publication number: 20110218250Abstract: The invention relates to compositions which comprise one or more glycerol ethers together with one or more diol/diols and/or polyol/polyols. As a result, as well as good microbicidal effectiveness, whitening is reduced or avoided, drying-out of the skin is prevented, the moisture content is regulated and the skin is regreased to an adequate extent.Type: ApplicationFiled: May 20, 2011Publication date: September 8, 2011Applicant: AIR LIQUIDE SANTE (INTERNATIONAL)Inventors: WOLFGANG BEILFUSS, Sabine Wutsch, Klaus Weber, Ralf Gradtke
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Publication number: 20110217397Abstract: The present invention comprises compositions, methods and cell lines related to controlling insects. An embodiment of a composition comprises a plant essential oil and targets at least one receptor of insects chosen from tyramine receptor, Or83b olfactory receptor, and Or43a olfactory receptor, resulting in a change in the intracellular levels of cAMP, Ca2+, or both in the insects.Type: ApplicationFiled: February 3, 2011Publication date: September 8, 2011Applicant: Tyra Tech, Inc.Inventor: Essam Enan
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Patent number: 7973076Abstract: The present invention provides compositions having, as active ingredients, a stilbene derivative and a platinum coordination compound which is highly efficacious and highly safe for treating tumors, particularly for the treatment of solid or malignant tumors and thus methods of cancer and tumor treatment using the composition are also provided.Type: GrantFiled: December 15, 2008Date of Patent: July 5, 2011Assignee: Ajinomoto Co., Inc.Inventors: Yoshihiro Morinaga, Yukio Nihei, Yasuyo Suga, Manabu Suzuki, Kazuo Ohishi, Akira Okano
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Publication number: 20110144043Abstract: The present invention is directed to methods, kits and compositions for modulating the activity of Stat molecules (e.g., Stat1, Stat3 and Stat5). The compounds of the invention are useful for treating and/or preventing disorders characterized by Stat dysregulation, such as hyperproliferative disorders. Further, the compounds of the present invention are also useful in culturing stem cells and treating ischemic disorders.Type: ApplicationFiled: December 11, 2009Publication date: June 16, 2011Applicant: Dana-Farber Cancer InstituteInventor: David A. Frank
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Publication number: 20110144212Abstract: The present invention provides a scalable process for the preparation of stilbenes by (i) condensing 3,5-dialkylbenzyl phosphonates with 4?-O-tetrahydropyranyl benzaldehyde to get 3,5-alkyl-4?-O-tetrahydropyranyl Stilbene and (ii) deprotecting the obtained 3,5-Dialkyl-4?-O-tetrahydropyranylstilbene to yield stilbenes. The present invention also provides a novel intermediate 3,5-Dialkyl-4?-O-tetrahydropyranyl stilbene, which is a key intermediate for the synthesis of stilbenes such as Pterostilbene and Resveratrol. The present invention also provides characteristics of various solid forms of Pterostilbene, methods for their preparation, as well as dosage forms containing the same for administration to or consumption by humans.Type: ApplicationFiled: January 21, 2011Publication date: June 16, 2011Applicant: APTUIT LAURUS PRIVATE LIMITEDInventors: Gottumukkala V. Subbaraju, Masna Mahesh, Hindupur R. Mohan, Thatipally Suresh, Igor Ivanisevic, Mark Andres, Kyle Stephens
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Publication number: 20110124742Abstract: The present invention is related to a composition and method of adipose cell differentiation inhibition.Type: ApplicationFiled: January 31, 2011Publication date: May 26, 2011Applicants: NATIONAL YANG-MING UNIVERSITY, YANGSON BIOTECHNOLOGY CO., LTD.Inventors: MENG-HWAN LEE, JUNG-WEI TSAI, YUN-YU CHEN, YING-CHIEH TSAI, CHUN-YING LIN
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Publication number: 20110092578Abstract: The present invention provides compounds and methods of using of the compounds as anti-infective and anthelminitc agents. In a preferred embodiment, the present invention provides the following compound of Formula III: wherein: R1 is not H when R2 is H and R2 is not H when R1 is H, further wherein R1 is OH or CH(2n+1)O, wherein n is 1-10; R2 is OH or CH(2n+1)O, where n is 1-10; W is alkyl, phenyl, halophenyl, pyridyl, piperidyl, or a substituted or unsubstituted aryl group, including unsubstituted and substituted aromatic heterocycles; and L is an optional linker or linking group selected from O, S, NH, CF2, or CH2, and x=0 or 1, i.e., if x=0, no linking group is present.Type: ApplicationFiled: December 20, 2010Publication date: April 21, 2011Inventors: Aaron P. Monte, M. Shahjahan Kabir, Marc A. Rott, William R. Schwan, James M. Cook, III, Jennifer A. Miskowski
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Publication number: 20110086818Abstract: The invention features methods, compositions, and kits for selective inhibition of pain-and itch sensing neurons (nociceptors and pruriceptors) by drug molecules of small molecule weight, while minimizing effects on non-pain-sensing neurons or other types of cells.Type: ApplicationFiled: March 11, 2009Publication date: April 14, 2011Applicants: Presidents and Fellows of Harvard College, The General Hospital CorporationInventors: Bruce P. Bean, Clifford J. Woolf
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Publication number: 20110082176Abstract: The present disclosure provides non-naturally occurring polyphenol compounds that upregulate the expression of Apolipoprotein A-I (ApoA-I). The disclosed compositions and methods can be used for treatment and prevention of cardiovascular disease and related disease states, including cholesterol or lipid related disorders, such as, e.g., atherosclerosis.Type: ApplicationFiled: October 15, 2010Publication date: April 7, 2011Inventors: Norman C.W. Wong, Joseph E.L. Tucker, Henrik C. Hansen, Fabrizio S. Chiacchia, David McCaffrey
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Publication number: 20110082126Abstract: A method for treating an autoimmune disease in a subject includes administering to the subject a therapeutically effective amount of an agent comprising an imidazole, an estrogen receptor agonist, or pharmaceutically acceptable salts thereof.Type: ApplicationFiled: June 2, 2009Publication date: April 7, 2011Inventor: Rekha Bansal
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Publication number: 20110060060Abstract: Resveratrol, a stilbenoid antioxidant found in grapes, wine, peanuts and other berries, has been reported to have hypolipidemic properties. Resveratrol and its three analogs (pterostilbene, piceatannol and resveratrol trimethyl ether) were evaluated for their effects on the activation of the peroxisome proliferator-activated receptor alpha (PPAR?) isoforms, a receptor shown to mediate the activity of lipid-lowering drugs such as the fibrates. The four stilbenes and ciprofibrate (positive control) were evaluated for the activation of endogenous PPAR? in H4IIEC3 cells. Pterostilbene demonstrated the highest induction of PPAR? demonstrating increases of 7- and 9-14 fold relative to control. The maximal responses to pterostilbene are similar to those obtained with the hypolipidemic drug, ciprofibrate; that is, pterostilbene acts as a PPAR? agonist, like that of the fibrate class, and is a more effective hypolipidemic agent than resveratrol.Type: ApplicationFiled: October 25, 2010Publication date: March 10, 2011Inventors: Agnes M. Rimando, Dennis R. Feller, Wallace H. Yokoyama
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Publication number: 20110054035Abstract: This invention relates to therapeutic combinations comprising VEGF Trap and a stilbene derivative, and to methods for treatment of cancer comprising administration of such combinations.Type: ApplicationFiled: November 9, 2010Publication date: March 3, 2011Applicant: AVENTIS PHARMA S.A.Inventors: Marie-Christine BISSERY, Patricia VRIGNAUD, Marielle CHIRON-BLONDEL, Brigitte DEMERS
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Publication number: 20110046235Abstract: The present invention relates to uses of decarboxylated phenolic acid derived from chlorogenic acid of coffee as well as products comprising decarboxylated phenolic acid derived from chlorogenic acid of coffee, especially a coffee extract, and methods of producing such products. Coffee comprises chlorogenic acids, according to the invention these chlorogenic acids can be transformed into decarboxylated phenolic acids. The resulting decarboxylated phenolic acids have antioxidant and/or anti-inflammatory properties and can be used as ingredients in food and beverage products and to treat certain health conditions.Type: ApplicationFiled: March 12, 2009Publication date: February 24, 2011Applicant: NESTEC S.A.Inventors: Rachid Bel-Rhlid, Karin Kraehenbuehl, Christophe Cavin, Thomas Wolfgang Raab, Nicolas Page
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Publication number: 20110003888Abstract: Methods and mixtures for extracting prenylflavonoids from prenylflavonoid-containing hops materials are provided.Type: ApplicationFiled: January 14, 2008Publication date: January 6, 2011Applicant: Bioactives, Inc.Inventor: Eric Kuhrts
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Publication number: 20100324149Abstract: The invention provides compositions and methods for reducing one or more symptoms of an autoimmune disease, inflammatory disease, and/or transplant rejection, by the administration to a subject in need thereof a pharmaceutically effective amount of a purified compound of any one of Formulae A-E. The invention's methods are useful for the prevention, amelioration, and treatment of autoimmune disease, inflammatory disease, and/or transplant rejection.Type: ApplicationFiled: July 26, 2010Publication date: December 23, 2010Inventor: Michael David
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Publication number: 20100305158Abstract: This invention concerns a method for treatment or prevention of lower urinary tract symptoms with or without pelvic pain in an individual, said method comprising administering to the individual an effective amount of a selective estrogen receptor modulator, or an isomer, isomer mixture or a pharmaceutically acceptable salt thereof.Type: ApplicationFiled: August 16, 2010Publication date: December 2, 2010Inventors: Risto Santti, Tomi Streng
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Publication number: 20100297059Abstract: The invention provides in part dialkoxybenzene and eugenol compounds for controlling infestation by a Lymantria dispar, and methods thereof. The compounds include a compound of Formula I: where R1 may be methyl, ethyl, propyl, n-butyl, isopentyl (3-methylbutyl) or allyl; R2 may be at positions 2, 3 or 4 and may be H, methyl, ethyl, propyl, n-butyl, isopentyl (3-methylbutyl) or allyl; and R3 may be optionally present at positions 2, 3 and 4, and is allyl; with the provisos that when R2 is at position 2, R3 if present is at position 3, or when R2 is at position 3, R3 if present is at positions 2 or 4, or when R2 is at position 4, R3 if present is at position 2; or of Formula II: where R1 may be methyl, ethyl, propyl, n-butyl, isopentyl (3-methylbutyl) or allyl; or mixtures thereof.Type: ApplicationFiled: April 7, 2010Publication date: November 25, 2010Applicant: Simon Fraser UniversityInventors: Erika Plettner, Yongmei Gong, Regine Gries
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Publication number: 20100280131Abstract: This invention relates to a method for inhibition of skin atrophy, or epithelial or mucosal atrophy in women, or to a method for treatment or prevention of symptoms related to said atrophy, said method comprising administering to the woman an effective amount of the compound of formula (I) or a geometric isomer, a stereoisomer, a pharmaceutically acceptable salt, an ester thereof or a metabolite thereofType: ApplicationFiled: July 15, 2010Publication date: November 4, 2010Inventors: Taru Blom, Paula Grönroos, Kaija Halonen, Pirkko Härkönen
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Publication number: 20100272818Abstract: The present invention relates to compositions comprising terpenes which are particularly suitable for treating plant infections, to methods of making such compositions, and to methods of using them. The present invention also relates to compositions comprising terpenes and hollow glucan particles or cell wall particles and methods for preparing such compositions; such compositions increase terpene stability and activity and provide a suitable carrier for the terpenes. The invention also relates to methods of using such compositions in the medical, veterinary and agricultural fields. In particular, the terpenes disclosed are thymol, eugenol, geraniol, citral and L-carvone.Type: ApplicationFiled: August 3, 2006Publication date: October 28, 2010Inventors: Lanny Franklin, Elizabeth Cloud, Lanna Knapp, Gary Ostroff
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Publication number: 20100267827Abstract: The present invention is related to a family of phenyl-prenyl-ether derivatives of formula (I), and to their use in the treatment of cognitive, neurodegenerative or neuronal diseases or disorders, such as Alzheimer's disease or 5 Parkinson's Disease. The present invention also relates to pharmaceutical compositions comprising the same. Further, the present invention is directed to the use of the compounds in the manufacture of a medicament for the treatment and/or prevention of a cognitive, neurodegenerative or neuronal disease or disorder.Type: ApplicationFiled: August 1, 2007Publication date: October 21, 2010Applicant: NOSCIRA, S.A.Inventors: Ana Martinez Gil, Ana Castro Morera, Miguel Medina Padilla, Pilar Munoz Ruiz, Javier Lopez Ogalla, Laura Rubio Arrieta, Esther Garcia Palomero, Pablo Garcia Fernandez, Celia De Austria De Luque, Elena Delgado Hernandez, Paola Usan Egea, Rita Valenzuela Liminana, Jorge Sanchez-Quesada
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Publication number: 20100249244Abstract: The presently claimed and disclosed inventive concept(s) contemplates compositions comprising compounds, in particular dihydroeugenol (DHE) and/or isoeugenol (IE) and/or ethyl vanillin (EV) or salts, esters, ethers, or derivatives thereof, and methods for topically or systemically delivering them for treatment against inflammation-related and other dermatological conditions such as described herein. These DHE and/or IE and/or EV or salts, esters, ethers or derivatives thereof also are delivered to a measurable extent transepidermally or transdermally.Type: ApplicationFiled: March 31, 2010Publication date: September 30, 2010Inventor: Bryan B. Fuller
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Publication number: 20100239552Abstract: This invention is directed to pharmaceutical combinations comprising an antioxidant agent, an anti-inflammatory agent, and optionally at least one other anti-diabetic agent useful for treating metabolic disorders. This invention also encompasses pharmaceutically acceptable compositions comprising an antioxidant agent, an anti-inflammatory agent, optionally at least one other anti-diabetic agent, and at least one pharmaceutically acceptable carrier.Type: ApplicationFiled: March 16, 2010Publication date: September 23, 2010Applicant: GENMEDICA THERAPEUTICS SLInventors: Eric Mayoux, Luc Marti Clauzel, Silvia Garcia-Vicente, Marta Serrano Munoz, Antonio Zorzano Olarte, Alec Mian
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Publication number: 20100240767Abstract: Disclosed is the cosmeceutical potential of 3,5-dimethoxy-4?-hydroxystilbene in terms of its melanogenesis inhibitory and photo protective activities. Also disclosed does a topical melanogenesis inhibitory composition comprising 0.01 to 50% by weight of 3,5-dimethoxy-4?-hydroxystilbene.Type: ApplicationFiled: March 23, 2009Publication date: September 23, 2010Inventors: MUHAMMED MAJEED, BEENA BHAT, GEETHA KANHANGAD-GANGADHARAN, SUSMITHA ANAND
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Publication number: 20100204340Abstract: A novel, bioavailable and safe stilbenoid 3,5-dimethoxy-3,4?-dihydroxystilbene represented by STR#1 with an unexpected enhanced ability to prevent the accumulation of lipids accompanying the terminal differentiation of adipocytes, thereby inhibiting adipogenesis, and nutraceutical and cosmeceutical compositions comprising 3,5-dimethoxy-3,4?-dihydroxystilbene useful for anti-obesity and anti-cellulite therapy, are disclosed. Further the enhanced SIRT-1 activation ability of 3,5-dimethoxy-3,4?-dihydroxystilbene represented by STR#1 and 2,3?,5?,6-tetrahydroxy-trans-stilbene represented by STR#II are disclosed. The enhancement of SIRT-1 polypeptide activity of the said compounds is unexpectedly much higher than resveratrol or its natural analog pterostilbene. Sirtuin modulating compositions comprising an orally bioavailable SIRT-1 enhancing compounds (i) 3,5-dimethoxy-3,4?-dihydroxystilbene represented by STR#I and (ii) 2,3?,5?,6-tetrahydroxy-trans-stilbene represented by STR#II are also disclosed.Type: ApplicationFiled: July 8, 2009Publication date: August 12, 2010Inventors: Muhammed Majeed, Jeffrey Reinhardt, Kalyanam Nagabhushanam, Samuel Manoharan Thomas, Krishnamani Jayaraman
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Publication number: 20100204339Abstract: Disclosed is a novel sirtuin modulating composition comprising an orally bioavailable SIRT-1 enhancing compound 3,5-dimethoxy-3,4?-dihydroxystilbene represented by STR#I. Also disclosed is an anti-acne composition comprising 3,5-dimethoxy- 3,4?-dihydroxystilbenes represented by STR#I. Further, a novel sirtuin modulating composition comprising an orally bioavailable SIRT-1 enhancing compound 2,3?,5?, 6-tetrahydroxy-trans-stilbene represented by STR#II is also disclosed.Type: ApplicationFiled: February 9, 2009Publication date: August 12, 2010Inventors: Muhammed Majeed, Jeffrey Reinhardt, Kalyanam Nagabhushanam, Samuel Manoharan Thomas, Krishnamani Jayaraman
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Publication number: 20100190803Abstract: Disclosed are bis(styryl)pyrimidine or bis(styryl)benzene compounds, represented by Chemical Formula 1, pharmaceutically acceptable salts, a method for preparing the same, and a pharmaceutical composition for the prevention and treatment of amyloidosis-associated diseases, comprising the same as an active ingredient. Having the ability to inhibit the deposition of beta amyloid and to reduce the toxicity of beta amyloid, the derivatives can improve learning and memory and can be useful in the prevention and treatment of amyloidosis-associated diseases.Type: ApplicationFiled: April 24, 2009Publication date: July 29, 2010Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGYInventors: Kye Jung SHIN, Eun Joo ROH, Yun Suk LEE
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Publication number: 20100160451Abstract: The invention provides in part dialkoxybenzene compounds for controlling infestation by a Trichoplusia ni, and methods thereof. The compounds include a compound of Formula I: where R1 may be methyl, ethyl, propyl, n-butyl, isopentyl(3-methylbutyl) or allyl; R2 may be at positions 2, 3 or 4 and may be H, methyl, ethyl, propyl, n-butyl, isopentyl(3-methylbutyl) or allyl; and R3 may be optionally present at positions 2, 3 and 4, and is allyl; except that when R2 is at position 2, R3 if present is at position 3, and when R2 is at position 3, R3 if present is at positions 2 or 4, and when R2 is at position 4, R3 if present is at position 2, and when R2 is at position 4 and R3, if present, has reacted with an OH group at position 1 in a Markovnikov sense, then R3 becomes R4, a dihydrofuran.Type: ApplicationFiled: November 19, 2009Publication date: June 24, 2010Applicants: Simon Fraser University, The University of British ColumbiaInventors: Erika Plettner, Murray Bruce Isman
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Publication number: 20100160450Abstract: Methods of reducing 15-F2t-IsoP levels in mammalian subjects are disclosed herein. In addition, methods of reducing or preventing oxidative stress and treating or preventing related diseases are disclosed.Type: ApplicationFiled: January 31, 2008Publication date: June 24, 2010Inventor: Eric Kuhrts
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Publication number: 20100136102Abstract: The present invention relates to compositions comprising terpenes and hollow glucan particles or cell wall particles and methods for preparing such compositions. The compositions increase terpene stability and activity and provide a suitable carrier for the terpenes. The invention also relates to methods of using such compositions,in the medical, veterinary and agricultural fields.Type: ApplicationFiled: August 3, 2006Publication date: June 3, 2010Inventors: Lanny Franklin, Elizabeth Cloud, Lanna Knapp, Gary Ostroff, Gary Harman
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Publication number: 20100129471Abstract: The invention relates to a compound of the formula (I) in which: R1, R2 and R3 are independently a methoxy group optionally substituted by one or more fluorine atoms; R4 is a hydrogen atom; R5 and R6 are identical and each represent a hydrogen or fluorine atom; A is a cycle selected from the group including aryl and heteroaryl groups, wherein said groups can be substituted.Type: ApplicationFiled: April 4, 2008Publication date: May 27, 2010Inventors: Mouâd Alami, Jean-Daniel Brion, Olivier Provot, Jean-François Peyrat, Samir Messaoudi, Abdallah Hamze, Anne Giraud, Jérôme Bignon, Joanna Bakala, Jian-Miao Liu
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Publication number: 20100119499Abstract: Disclosed are compositions, formulations and methods relating to one or more stilbene-based compounds for use in humans. In particular, compositions and formulations comprising an effective amount of the stilbene-based insulinogenic compound can improve athletic performance, lower blood glucose levels, and increase lean muscle mass when administered (e.g., orally) to a human.Type: ApplicationFiled: January 15, 2010Publication date: May 13, 2010Inventors: Bruce W. Kneller, Daniel C. Pierce, Joseph Babick, JR.
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Publication number: 20100120911Abstract: Disclosed is a novel method for preserving cosmetic/personal care formulations through a two component preservative system, said system comprising (a) Component I which functions to eliminate the existing microbial contamination load in a natural cosmetic formulation base through an optimized pasteurization method that avoids deep freezing; and (b) Component II that includes the step of adding synergistic blends of fractionated essential oils, extracts and isolated compounds to the pre-pasteurized cosmetic base obtained through the method of component I, wherein the synergistic blends sustain the effects of pasteurization through anti-microbial and anti-oxidant effects, said anti-oxidant effects enhancing further the anti-microbial effects by virtue of inhibiting lipid per oxidation that facilitates the undue proliferation of microbe.Type: ApplicationFiled: May 4, 2009Publication date: May 13, 2010Inventors: Muhammed Majeed, Beena Bhat, Garima Agarwal
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Patent number: 7708990Abstract: The object of the present invention is to provide a composition maintaining a blood coenzyme Q concentration at a high level in blood for a prolonged period of time, in order to surely attain an effect of coenzyme Q, which can be expected to manifest a superior effect in maintaining health in humans and animals. By using a composition which comprises a coenzyme Q being a mixture of a reduced coenzyme Q and an oxidized coenzyme Q with the proportion of the reduced coenzyme Q to the whole coenzyme Q of more than 95% by weight, the present invention can attain a high maximum blood concentration of a coenzyme Q as well as long maintenance of high concentration of coenzyme Q in blood for a prolonged period of time, and the area under the blood concentration curve (AUC) can be expanded.Type: GrantFiled: March 22, 2005Date of Patent: May 4, 2010Assignee: Kaneka CorporationInventors: Kenji Fujii, Taizo Kawabe, Hiroshi Kubo
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Patent number: 7700657Abstract: Novel vitamin D analogs, markedly active in the fields of cell proliferation and differentiation, are selected from among (4E,6E)-7-{3-[2-(3,4-bis-hydroxymethylphenyl)-ethyl]phenyl}-3-ethylnona-4,6-dien-3-ol, (E)-6-[3-(3,4-bis-hydroxymethylbenzyloxy)phenyl]1,1,1-trifluoro-2-trifluoromethyloct-5-en-3-yn-2-ol, (3E,5E)-6-[3-(3,4-bis-hydroxymethylbenzyloxy)-phenyl]-1,1,1-trifluoro-2-trifluoromethylocta-3,5-dien-2-ol, (E)-6-{3-[2-(3,4-bis-hydroxymethylphenyl)ethyl]phenyl}-1,1,1-trifluoro-2-trifluoromethyloct-5-en-3-yn-2-ol, and (3E,5E)-6-{3-[2-(3,4-bis-hydroxymethylphenyl)-ethyl]phenyl-1,1,1-trifluoro-2-trifluoromethylocta-3,5-dien-2-ol, and the geometric isomers thereof and these compounds in which one or more of the hydroxyl functions are protected by a protective group —(C?O)—R, in which R is a linear or branched alkyl radical having from 1 to 6 carbon atoms, an aryl radical having from 6 to 10 carbon atoms, or an aralkyl radical having from 7 to 11 carbon atoms, the aryl radical or the aralkyl radical optionalType: GrantFiled: November 24, 2003Date of Patent: April 20, 2010Assignee: Galderma Research & DevelopmentInventor: Jean-Michel Bernardon
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Publication number: 20100087527Abstract: The present invention is directed to a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula (I) are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula (I) and its therapeutic use.Type: ApplicationFiled: September 30, 2009Publication date: April 8, 2010Applicant: Codman & Shurtleff, Inc.Inventor: Thomas M. DiMauro
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Patent number: 7671055Abstract: Certain novel 3-(dihaloalkenyl)phenyl derivatives have unexpected insecticidal activity. These compounds are represented by formula (I), where R through R5, a, b, D, E, G and U are fully described herein. In addition, compositions comprising an insecticidally effective amount of at least one compound of formula (I), and optionally, an effective amount of at least one of second compound, with at least one insecticidally compatible carrier are also disclosed; along with methods of controlling insects comprising applying said compositions to a locus where insects are present or are expected to be present.Type: GrantFiled: October 20, 2005Date of Patent: March 2, 2010Assignee: FMC CorporationInventors: Edward J. Barron, Y. Larry Zhang, Frank J. Zawacki, John W. Lyga, George Theodoridis
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Publication number: 20100041768Abstract: The present invention is related to a composition and method of adipose cell differentiation inhibition.Type: ApplicationFiled: August 18, 2008Publication date: February 18, 2010Applicants: NATIONAL YANG-MING UNIVERSITY, YANGSON BIOTECHNOLOGY CO., LTD.Inventors: MENG-HWAN LEE, JUNG-WEI TSAI, YUN-YU CHEN, YING-CHIEH TSAI, CHUN-YING LIN
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Publication number: 20100034907Abstract: An aqueous disinfectant formulation comprising at least one phenolic compound of natural origin; a surfactant sufficient to form a solution or dispersion of the essential oil in an aqueous carrier; a solvent, and sufficient water to make 100 weight percent is described herein.Type: ApplicationFiled: April 8, 2009Publication date: February 11, 2010Applicant: Laboratoire M2Inventors: François Daigle, Ann Letellier, Sylvain Quessy
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Patent number: 7655696Abstract: The present invention provides composition having as active ingredients a stilbene derivatively and a platinum coordination compound which is highly efficacious and highly safe for treating tumors, particularly for the treatment of solid or malignant tumors and thus methods of cancer and tumor treatment using the composition are also provided.Type: GrantFiled: August 4, 2005Date of Patent: February 2, 2010Assignee: Ajinomoto Co., Inc.Inventors: Yoshihiro Morinaga, Yukio Nihei, Yasuyo Suga, Manabu Suzuki, Kazuo Ohishi, Akira Okano
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Publication number: 20090324740Abstract: Systems and methods are disclosed for treating a plurality of sinsousal conditions to be treated. These systems and methods include selecting a combination of at least two compounds that are capable of addressing a plurality of sinsousal conditions. At least one of the at least two compounds is selected from a group of anti fungals, antioxidants, and chelators. These systems and methods also include verifying that the compounds are biologically compatible and creating a combination compound using the selected compounds.Type: ApplicationFiled: June 15, 2009Publication date: December 31, 2009Inventor: Ford D. Albritton, IV
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Publication number: 20090312274Abstract: Estrogenic compositions comprising nyasol and analogs thereof are provided. Also provided are methods of using said extracts to achieve an estrogenic effect, especially in a human, e.g. a female human. In some embodiments, the methods include treatment of climacteric symptoms. In some embodiments, the methods include treatment of estrogen receptor positive cancer, such as estrogen responsive breast cancer. In some embodiments, the methods include treatment or prevention of osteoporosis.Type: ApplicationFiled: June 12, 2009Publication date: December 17, 2009Applicant: Bionovo, Inc.Inventor: Isaac Cohen
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Publication number: 20090258098Abstract: An antifungal composition and penetrating carrier system for topical treatment of dermatophytic infection and secondary bacterial infections. The antifungal composition includes various fungistatic and fungicidal essential oil components, or combinations thereof. The penetrating carrier system may include various ingredients, including a penetration enhancer, such as isopropyl myristate.Type: ApplicationFiled: April 14, 2009Publication date: October 15, 2009Inventors: LANE ROLLING, Craig Oberg, Evan Call
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Publication number: 20090258937Abstract: Methods and pharmaceutical compositions for modulating tumor growth or metastasis are provided.Type: ApplicationFiled: November 7, 2008Publication date: October 15, 2009Inventors: Francis Y. Lee, Ronald Peck, David Chaplin, Ronald Pero, Klaus Edvardsen
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Publication number: 20090220625Abstract: Described is a formulation having a skin irritation-reducing action consisting of or comprising: bisabolol and a composition or compound chosen from the group consisting of a) substance mixtures obtainable from an extraction of ginger, b) substance mixtures obtainable from a separation of a ginger extract which comprise a compound which is chosen from the group consisting of gingerols, shogaols, gingerdiols, dehydrogingerdiones, paradols and derivatives thereof and c) compounds obtainable from a separation of a ginger extract which are chosen from the group consisting of gingerols, shogaols, gingerdiols, dehydrogingerdiones, paradols and derivatives thereof and mixtures thereof, wherein the particular content of bisabolol and of the said composition or compound in the formulation is adjusted such that the skin irritation-reducing action of these contents is increased synergistically.Type: ApplicationFiled: October 6, 2006Publication date: September 3, 2009Inventors: Martina Herrmann, Gabriele Vielhaber, Imke Meyer, Holger Joppe
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Publication number: 20090163600Abstract: An anti-inflammatory agent or cancer-preventive agent comprising 4-vinyl-2,6-dimethoxyphenol of the formula (1): or a PD thereof.Type: ApplicationFiled: March 30, 2006Publication date: June 25, 2009Inventors: Hiroshi Maeda, Tetsuya Tsukamoto, Masae Tatematsu
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Publication number: 20090163580Abstract: Formulations and methods of treatment and putative prevention for aging (anti-aging composition) and for diseases or conditions of all reactive oxygen species-dependant illnesses, such as Alzheimer's disease, Parkinson's disease, diabetes mellitus, cardiovascular disease, cancer, hepatitis, and disorders associated with estrogen deficiencies including osteoporosis and breast cancer and for improving athletic performance of humans include resveratrol and two (2) or more of the following features or additional active ingredients: (1) slow release formulation of resveratrol; (2) pterostilbene; (3) quercetin; (4) fisetin, and (5) naringenin. Slow release is defined for the purposes of the present invention as releasing 95% of the active agent or agents in eight (8) hours through normal human gastrointestinal absorption.Type: ApplicationFiled: December 18, 2008Publication date: June 25, 2009Inventors: Michael Todd Yatcilla, Dallas Clouatre, Edward Anthony Byrd, Amy Addington Fitzpatrick