Plural Benzene Rings Patents (Class 514/721)
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Publication number: 20120121665Abstract: Disclosed are implantable or insertable medical devices that provide resistance to microbial growth on and in the environment of the device and resistance to microbial adhesion and biofilm formation on the device. In particular, the invention discloses implantable or insertable medical devices that comprise at least one biocompatible matrix polymer region, an antimicrobial agent for providing resistance to microbial growth and a microbial adhesion/biofilm synthesis inhibitor for inhibiting the attachment of microbes and the synthesis and accumulation of biofilm on the surface of the medical device.Type: ApplicationFiled: January 24, 2012Publication date: May 17, 2012Applicant: BOSTON SCIENTIFIC SCIMED, INC.Inventors: Kathleen M. Miller, Gregory T. Sydney, Kurt Geitz, Peter L. Dayton, Ronald A. Sahatjian
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Publication number: 20120115812Abstract: The present invention relates to skin coating compositions and methods and, in particular, to coatings containing an active agent. In some embodiments, the coating may be applied to a skin surface and may be essentially colorless and transparent. In some aspects, the coating comprises a polymer and an active agent, and the polymer may be configured for sustained release of the active agent. In some aspects, the coating forms a barrier essentially impermeable to microorganisms yet permeable to water vapor. The coating may also be flexible and conformable to the surface. The coating may be applied to the skin using any suitable method. In some embodiments, the polymer and/or active agent are dissolved and/or suspended in a volatile solvent. In some embodiments, the volatile solvent may function as an antiseptic on skin.Type: ApplicationFiled: January 17, 2012Publication date: May 10, 2012Applicant: Pharmasol CorporationInventor: James Donald Hammer
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Publication number: 20120107415Abstract: The invention relates to a novel combined disinfection and decontamination agent comprising at least one vitamin, at least one metal ion, at least one active-surface compound, and at least one further antimicrobial active substance. The agent according to the invention surprisingly shows nearly complete nucleic acid disintegration in addition to an improved disinfectant effect. The agent can be successfully used as a combined decontamination and disinfection agent for skin, mucous membranes, hands, wounds, and/or hair, and instruments and surfaces of all kinds.Type: ApplicationFiled: November 14, 2009Publication date: May 3, 2012Inventors: Thomas Lisowsky, Sven Eggerstedt, Richard Bloss, Christiane Ostermeyer, Karlheinz Esser, Frank Bürger, Barbara Krug, Yvonne Feil, Kai-Martin Mueller, Delphine Haase
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Publication number: 20120087913Abstract: Methods and compositions for enhancing the ability of hypoxia-activated bioreductive agents to kill tumor cells within solid tumors are provided. Local regions of hypoxia are created within a tumor, or within a region containing a tumor, resulting in enhanced activation of hypoxia-activated bioreductive agents (e.g. tirapazamine) within the local region. The activated hypoxia-activated bioreductive agents kill tumor cells in the hypoxic region by catalyzing DNA stand breakage within the tumor cells. Because the activity is localized, side effects that typically occur as a result of systemic administration of bioreductive agents are reduced.Type: ApplicationFiled: April 8, 2009Publication date: April 12, 2012Inventors: Ruey-min Lee, Peck-sun Lee
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Publication number: 20120052106Abstract: A surface of an object may be treated using an antimicrobial wipe presoaked in an antimicrobial treatment solution. Alternatively, the antimicrobial treatment solution may be sprayed directly on the surface. The antimicrobial treatment solution may be made of isopropyl alcohol and an unreacted organofunctional silane antimicrobial substance that is substantially free from arsenic, silver, tin, heavy metals and polychlorinated phenols. The antimicrobial substance may include any one of: 3 trimethoxysilylpropyloctadecyldimethyl ammonium chloride; hyaluronan and its derivatives; triclosan; and a copolymer of chloropropyltrihydroxysilane and octadecylaminodimethyltrihydroxysilylpropyl ammonium chloride.Type: ApplicationFiled: July 14, 2011Publication date: March 1, 2012Inventor: Patrick E. Eddy
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Publication number: 20120052026Abstract: Antiplaque oral compositions are provided that contain an orally acceptable carrier and an antibacterial effective amount of the compound of formula (I). In various embodiments, the compositions contain from about 0.001% to about 10% by weight of the compound of formula (I).Type: ApplicationFiled: November 9, 2011Publication date: March 1, 2012Applicant: COLGATE-PALMOLIVE COMPANYInventors: Ravi Subramanyam, Prem Sreenivasan
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Publication number: 20120039977Abstract: The invention includes a microbe-mitigating architectural barrier that includes a barrier forming material, and at least one biocide. The barrier forming material may be a bitumen product, an elastomeric polymer and combinations thereof. The microbe-mitigating architectural barrier may be formed by applying an emulsion composition directly to an architectural surface, or it may be preformed and adhered or otherwise secured to the architectural surface in the form of a sheet or film. The invention also includes architectural assemblies and/or building envelopes that include the microbe-mitigating barrier. Related methods are encompassed within the scope of the invention.Type: ApplicationFiled: February 16, 2011Publication date: February 16, 2012Inventors: John Dracopoulos, Lionel Borenstein, Shawn Melancon
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Publication number: 20110311629Abstract: The present invention is a substantially non-adhesive elastic gelatin matrix. The matrix is both non-adhesive to wounds, tissues and organs and is also elastic such that it is flexible. The matrix is a lyophilized mixture of protein(s), polymer(s), cross-linking agent(s) and optional plasticizer(s). The invention also provides methods for making the non-adhesive elastic gelatin matrix.Type: ApplicationFiled: June 22, 2011Publication date: December 22, 2011Inventors: Valerio DiTizio, Frank Dicosmo, Yuehua Xiao
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Publication number: 20110312496Abstract: Concentrated microemulsions comprising: 1) 10-25 parts by weight of a pesticide with a solubility in water at 20° C. lower than 1% l by weight and having a melting point from 10° C. to 60° C.; 2) 8-25 parts by weight of one or more solvents containing oxygen atoms, having a solubility in water at 20° C. lower than 5% by weight and the Hildebrand solubility parameter in the range 16-21 MPa1/2; 3) 10-20 parts by weight of a polyol; 4) 10-25 parts by weight of one or more non ionic surfactants having a HLB value from 9 to 15; 5) 2-10 parts by weight of one or more anionic surfactants; 6) water up to 100 parts by weight; wherein—the ratio by weight between 2) and 1) ranges from 0.8:1 to 1.5:1;—the ratio by weight between 4) +5) and 1) is in the range 0.5:1-3:1;—the ratio by weight between 4) and 5) ranges from 1:1 to 4.1.Type: ApplicationFiled: August 30, 2011Publication date: December 22, 2011Applicant: SIPCAM S.P.A.Inventors: Marco BERNARDINI, Francesca BORGO, Luigi CAPUZZI, Pietro DOMENICHINI, Giorgio FRESCHI
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Publication number: 20110301553Abstract: An antimicrobial lubricant combines an antimicrobial agent, preferably silver based, with a silicone lubricant. This is achieved by first formulating a lubricant solution that has a non-volatile silicone lubricant and a volatile solvent carrier. An antimicrobial agent is added to the lubricant solution. The solution is then subjected to ultrasonic energy so that the antimicrobial agent is uniformly mixed with the lubricant in the solution. The solution containing the antimicrobial lubricant may be sprayed onto a medical device, for example the outer surface of the catheter of a peripheral IV catheter. After the solvent flashes off, a coat of uniform antimicrobial lubricant is formed on the catheter surface. The antimicrobial lubricant coating facilitates the insertion of the catheter to a patient, and at the same time prevents the growth of microorganisms from the device and infection to the patient.Type: ApplicationFiled: June 4, 2010Publication date: December 8, 2011Applicant: Smiths Medical ASD, Inc.Inventors: David Goral, Harsh Chheda, Jane Wronka
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Publication number: 20110293682Abstract: One embodiment includes a biocide-containing and/or fungicide-containing microcapsule wherein the microcapsule may be capable of degradation due to the presence of byproducts that are released by a fungi or biological organism. Upon release, the biocide and/or fungicide may then be utilized to eliminate the fungi or biological organism.Type: ApplicationFiled: May 25, 2010Publication date: December 1, 2011Applicant: GM GLOBAL TECHNOLOGY OPERATIONS, INC.Inventors: Michael J. Walker, Charles H. Olk
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Publication number: 20110287083Abstract: Bioabsorbable compositions of A) blends of bioabsorbable homopolymers and/or copolymers containing glycolide and lactide and B) salts of fatty acids and/or fatty acid esters are described. Processes for making the compositions and surgical articles made totally or in part therefrom, including suture coatings, are also described.Type: ApplicationFiled: July 21, 2011Publication date: November 24, 2011Applicant: Tyco Healthcare Group LPInventor: Ahmad R. Hadba
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Publication number: 20110230556Abstract: This invention provides compound having a structure of Formula I or Formula II. Uses of such compounds for treatment of various indications, including prostate cancer as well as methods of treatment involving such compounds are also provided.Type: ApplicationFiled: July 2, 2009Publication date: September 22, 2011Inventors: Marianne D. Sadar, Nasrin R. Mawji, Jun Wang, Raymond J. Andersen, David E, Williams, Mike Leblanc
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Publication number: 20110207830Abstract: Disclosed is a composition for treating or preventing amyloid-related diseases including 4-O-methylhonokiol as an active ingredient. More specifically, a pharmaceutical composition including 4-O-methylhonokiol, which is effective for treating or preventing amyloid-related diseases such as Alzheimer's disease, cognitive disorder, defective memory, amyloidosis, etc. is disclosed. The inventors of the present disclosure have found out for the first time that 4-O-methylhonokiol inhibits the production of ?-amyloid. It has been confirmed to be useful in treating or preventing amyloid-related diseases. Through animal tests including water maze test and passive avoidance test on mice, 4-O-methylhonokiol has been confirmed to be effective for amyloid-related diseases such as Alzheimer's disease, defective memory, cognitive disorder, and the like.Type: ApplicationFiled: September 25, 2009Publication date: August 25, 2011Applicant: BIOLAND LTD.Inventors: Ki Ho Kim, Ki Soo Kim, Young Heui Kim, Jin Guk Kim, Kyoung Tae Kim, Chang Sung Han, Sang iL Lee
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Patent number: 8003703Abstract: The invention relates to certain 2-substituted phenoxyacetic acid derivatives of formula (I), in which the variables are as defined in the claims, useful in the treatment of diseases or conditions in which modulation of the CRTh2 receptor is beneficial, such as asthma and rhinitis.Type: GrantFiled: August 18, 2004Date of Patent: August 23, 2011Assignee: AstraZeneca ABInventors: Roger Victor Bonnert, Anil Patel, Stephen Thom
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Publication number: 20110200656Abstract: A material for use in currency comprises an antimicrobial polymer material which can be used in the manufacture of banknotes having security features therein. The material can be a sheet or substrate and/or an acrylate polymer coat applied to at least one surface of a banknote.Type: ApplicationFiled: February 9, 2007Publication date: August 18, 2011Applicant: MICROBAN PRODUCTS COMPANYInventor: Anders Olsson
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Publication number: 20110166192Abstract: The invention relates to a process for charging a polymeric product with attribute imparting agent(s) to the polymeric product prepared by the process and to a composition for preparing the polymeric product capable of retaining the acquired attributes for a long period of time.Type: ApplicationFiled: March 10, 2011Publication date: July 7, 2011Applicant: ADITYA BIRLA SCIENCE & TECHNOLOGY CO. LTD.Inventors: Preeti LODHA, Bir KAPOOR, Tushar MAHAJAN, Anasuya SAHOO
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Publication number: 20110160228Abstract: The present invention relates to compounds of formula (I) below in which: —R1 and R3 represent, independently of one another, a methoxy group optionally substituted by one or more fluorine atoms, —R2 and R4 represent, independently of one another, a hydrogen atom or a methoxy group optionally substituted by one or more fluorine atoms, —A represents a ring chosen from the group comprising aryl and heteroaryl groups, said ring possibly being substituted by or fused to a heterocycle, —X represents a nitrogen atom or a CH group, and —Z1 represents a hydrogen atom or a halogen atom, preferably fluorine, and —Z2 represents a hydrogen atom, a halogen atom, preferably fluorine, a C1 to C4 alkyl group, an aryl group or a —CN, —SO2NR12R13, —SO2R9, —COOR15 or —COR15 group, and also to the pharmaceutically acceptable salts thereof, the isomers thereof and the prodrugs thereof.Type: ApplicationFiled: June 4, 2009Publication date: June 30, 2011Inventors: Mouâd Alami, Samir Messaoudi, Abdallah Hamze, Olivier Provot, Jean-Daniel Brion, Jian-Miao Liu, Jérôme Bignon, Joanna Bakala
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Publication number: 20110152372Abstract: Novel dermatological depigmentation compositions, especially for topical application, contain as pharmaceutical active agents a dissolved phenolic compound and a retinoid, formulated as anhydrous compositions free of petroleum jelly and free of elastomer. The present invention relates to a novel depigmenting composition especially for topical application, comprising as pharmaceutical active agents a dissolved phenolic derivative and a retinoid, in the form of an anhydrous composition free of petroleum jelly and free of elastomer, to the process for preparing it and to its use in dermatology.Type: ApplicationFiled: June 2, 2009Publication date: June 23, 2011Applicant: Galderma Research & DevelopmentInventors: Claire Mallard, Karine Nadau-Fourcade, Fabienne Louis
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Publication number: 20110144213Abstract: Novel anhydrous dermatological depigmenting compositions, especially for topical application, contain, as pharmaceutical active agent, a phenolic compound dissolved in a fatty phase therefor.Type: ApplicationFiled: June 2, 2009Publication date: June 16, 2011Inventors: Claire Mallard, Karine Nadau-Fourcade, Fabienne Louis
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Publication number: 20110135702Abstract: A cleaning medium or formulation that contains a sporicidal composition is described. The composition includes about 0.1-20% weight/weight of a germinant agent, about 0.01-75% w/w of an antimicrobial agent, in terms of dry or wet total weight, and which is admixed with water to generate a solution with a pH of 3.5-9.5. The composition can help trigger the germination of spores, in particular C. difficile, and subsequently deactivate or kill the spores. A means of applying the cleaning formulation in a medium and process for cleaning are also described.Type: ApplicationFiled: December 9, 2009Publication date: June 9, 2011Inventors: Douglas R. Hoffman, Aimin He, David W. Koenig, Andrea J. Smiltneek, DaeGun Kim, YoungSook Kim
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Publication number: 20110135711Abstract: The present invention provides kits, methods and compositions for the treatment of diseases such as cancers. The compositions herein contain a substantially pure preparation of at least one catecholic butane, including, for example, NDGA compounds in a pharmaceutically acceptable carrier or excipient. The catecholic butane such as NDGA or its derivatives are administered to one or more subjects in need of treatment by a route other than direct injection into the affected tissues or topical application on affected tissues.Type: ApplicationFiled: May 31, 2010Publication date: June 9, 2011Inventors: Ru Chih C. Huang, Richard Park, Chih-Chuan Chang, Yu-Chuan Liang, David Mold, Elaine Lin, Jonathan Heller, Neil Frazer
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Publication number: 20110129512Abstract: The present disclosure is directed to polymers having hydroxyl containing bioactive agents incorporated into the backbone of the polymer or attached thereto by pendant linkages. Hydroxyl containing bioactive agents which may be attached to these polymers include antimicrobial agents such as triclosan. The polymers may be utilized to form medical devices or coatings for such devices. The hydroxyl containing bioactive agent may be released from the polymer upon hydrolysis of the polymeric backbone or pendant linkage in vivo.Type: ApplicationFiled: January 28, 2011Publication date: June 2, 2011Applicant: Tyco Healthcare Group LPInventors: Mark Roby, John Kennedy, Joshua B. Stopek, Brian Cuevas, Nadya Belcheva
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Publication number: 20110130467Abstract: A method for producing an antimicrobial-containing solution includes mixing an alkaline aqueous solution which dissolves a phenol-based antimicrobial, and has a pH of 9 or higher and acid which has a pH 6 or lower.Type: ApplicationFiled: July 22, 2009Publication date: June 2, 2011Inventors: Kazuo Matsuyama, Koji Mine, Hiromi Kubota, Takehisa Yano
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Patent number: 7947297Abstract: Plastic films, fibers and articles are provided long-term antimicrobial activity with a combination of certain phenolic and inorganic antimicrobial agents. The plastic films, fibers and articles with antimicrobial activity exhibit superior resistance to discoloration, may be processed at high temperature, and maintain physical properties upon weathering, especially upon exposure to ultraviolet radiation.Type: GrantFiled: November 18, 2004Date of Patent: May 24, 2011Assignee: BASF SEInventors: Heinz Herbst, Urs Stadler
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Patent number: 7947296Abstract: Plastic films, fibers and articles are provided long-term antimicrobial activity with a combination of certain phenolic and inorganic antimicrobial agents. The plastic films, fibers and articles with antimicrobial activity exhibit superior resistance to discoloration, may be processed at high temperature, and maintain physical properties upon weathering, especially upon exposure to ultraviolet radiation.Type: GrantFiled: December 18, 2002Date of Patent: May 24, 2011Assignee: BASF SEInventors: Heinz Herbst, Urs Stadler
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Publication number: 20110117048Abstract: Composition for application to skin comprising a biocide or combination of biocides (such as chlorhexidine, halogenated phenols, quaternary ammonium compounds; povidone-iodine; zinc pyridinethione; alcohols etc.) and at least one transcutaneous vehicle (for example alkyl methyl sulfoxides, alkyl pyrrolidones, glycols, glycol ethers and glycol esters) effective to convey the biocide to a sub epidermal “resident” micro-organism. Also a method for preparing a patient for surgery comprising the step of treating an area of the patient's skin at, and in the surrounding the vicinity of, the site of an intended surgical incision with a composition effective to kill more than 93% of both “transient” and “resident” micro-organisms.Type: ApplicationFiled: January 20, 2011Publication date: May 19, 2011Applicant: Novapharm Research (Australia) Pty Ltd.Inventor: Steven Kritzler
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Patent number: 7943670Abstract: Described is a soluble stable liquid formulation, process for preparing, and a method of using the soluble stable liquid formulation comprising ractopamine or a physiologically acceptable salt thereof, a liquid nonionic cosolvent, and water.Type: GrantFiled: October 4, 2004Date of Patent: May 17, 2011Assignee: Eli Lilly and CompanyInventors: Michael David Burton, Sr., Paul Reuben Klink
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Publication number: 20110111000Abstract: There is described a surface mountable delivery device which has a multi layer construction comprising a liquid permeable support layer adjacent to a porous reservoir layer, the porous reservoir layer being provided with a backing layer. The surface mountable delivery device may comprise of stickers, tapes, pads, tubes, socks, etc.Type: ApplicationFiled: November 19, 2008Publication date: May 12, 2011Applicant: SURFACESKINS LIMITEDInventors: STEPHEN JOHN RUSSELL, MATTHEW JAMES TIPPER, MANOJ KANTILAL CHHAGANLAL RATHOD, ADAM DAVID WALKER, SIMON GEOFFREY JOHN SCOTT-HARDEN
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Patent number: 7939516Abstract: A cream base for the topical application of skin care therapeutics and a process for making the cream base. In one embodiment, the therapeutic is tretinoin, hydroquinone and fluocinolone acetonide for the treatment of hyperpigmented skin conditions, such as melasma.Type: GrantFiled: May 11, 2007Date of Patent: May 10, 2011Assignee: Galderma S.A.Inventors: Nancy Puglia, Jerry Roth, Rosario Ramirez
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Publication number: 20110105624Abstract: The present invention relates to the field of molecules suitable for treatment of inflammation through inhibitory actions in one or more steps of the Arachidonic Acid pathway. Specifically the present invention provides an improvement in the use of Endipalene molecules as anti-inflammatory pharmaceutical agents, more specifically as 5-lipoxygenase inhibitor agents, for treating inflammation and inflammation-related skin disorders.Type: ApplicationFiled: May 8, 2009Publication date: May 5, 2011Inventor: Glorgio Endrici
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Publication number: 20110098724Abstract: A medical device having an antimicrobial coating. The device has a first coating layer having an antimicrobial agent over at least part of the outer surfaces of the device. The first coating has an outer surface. There is a second discontinuous polymeric coating containing an antimicrobial agent, which is on top of and covering part of the outer surface of the first coating. The second discontinuous coating has a microstructure.Type: ApplicationFiled: October 28, 2009Publication date: April 28, 2011Inventors: Frank Cichocki, Michael (Jake) Hamilton, Xintian Ming
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Publication number: 20110076250Abstract: A biodegradable microfiber absorbent comprises a substantially homogeneous mixture of at least one hydrophilic polymer and at least one biodegradable polymer. The absorbent can be prepared by an electro hydrodynamic spinning of a substantially homogeneous polymer mixture. Medical dressings for burns and wounds, cavity dressings, drug delivery patches, face masks, implants, drug carriers that comprises at least one microfiber electrospun from a polymer mixture are provided. The dressings can have variable water vapor penetration characteristics and variable biodegradation times.Type: ApplicationFiled: December 7, 2010Publication date: March 31, 2011Inventors: Bronislava G. Belenkaya, Vyacheslav N. Polevov, Valentina I. Sakharova, Claudia Polevov
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Publication number: 20110076244Abstract: The present invention relates to skin coating compositions and methods and, in particular, to coatings containing an active agent. In some embodiments, the coating may be applied to a skin surface and may be essentially colorless and transparent. In some aspects, the coating comprises a polymer and an active agent, and the polymer may be configured for sustained release of the active agent. In some aspects, the coating forms a barrier essentially impermeable to microorganisms yet permeable to water vapor. The coating may also be flexible and conformable to the surface. The coating may be applied to the skin using any suitable method. In some embodiments, the polymer and/or active agent are dissolved and/or suspended in an alcohol solvent. In some embodiments, the alcohol may function as an antiseptic on skin.Type: ApplicationFiled: September 24, 2010Publication date: March 31, 2011Applicant: Pharmasol CorporationInventor: James Donald Hammer
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Patent number: 7915243Abstract: A cream base for the topical application of skin care therapeutics and a process for making the cream base. In one embodiment, the therapeutic is tretinoin, hydroquinone and fluocinolone acetonide for the treatment of hyperpigmented skin conditions, such as melasma.Type: GrantFiled: December 15, 2004Date of Patent: March 29, 2011Assignee: Galderma S.A.Inventors: Nancy Puglia, Rosario Ramirez, Jerry Roth
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Publication number: 20110070284Abstract: Described herein are methods and compositions related to biologic matrices comprising at least one anti-infective. In certain embodiments, the invention relates to a biologic matrix comprising a slowed release anti-infective agent. In a particular embodiment, the invention relates to an acellular dermal matrix comprising a slowed release antiinfective agent, wherein the anti-infective agent is triclosan. In further embodiments, the the biologic matrix is suitable for use in surgical procedures, such as, for example, for the replacement of damaged or inadequate integumental tissue or for the repair, reinforcement or supplemental support of soft tissue defects.Type: ApplicationFiled: February 23, 2009Publication date: March 24, 2011Applicant: MUSCULOSKELETAL TRANSPLANT FOUNDATIONInventors: Carl Alexander Depaula, Arthur A. Gertzman, Moonhae Sunwoo
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Publication number: 20110014192Abstract: Disclosed is a composition comprising a derivative of NDGA and at least one metabolic modulator. The composition can be in a unit dose form or kit. The composition can comprise at least two metabolic modulators. Also disclosed are methods for achieving cytotoxicity, particularly of rapidly dividing cells such as cancer, by administering a composition of the invention. In various embodiments of the invention subjects with cancer achieve prolonged survival and/or diminution in the size of their malignancies and cancer metastasis.Type: ApplicationFiled: January 8, 2009Publication date: January 20, 2011Applicant: The Johns Hopkins UniversityInventors: Ru Chih Huang, Kotohiko Kimura
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Publication number: 20110009831Abstract: An antimicrobial coating applied to a transdermal surface of a catheter device. An antimicrobial coating applied to catheter device such that when the catheter device is fully inserted, the antimicrobial coating is interposed between the catheter device and the dermal layers of the patient.Type: ApplicationFiled: July 7, 2010Publication date: January 13, 2011Applicant: BECTON, DICKINSON AND COMPANYInventors: Jonathan Karl Burkholz, Minh Quang Hoang
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Publication number: 20100330006Abstract: Methods of using absorption enhancer as a component of skin care compositions for moisturizing and protecting the skin. Antimicrobial skin care compositions for cleansing and moisturizing the skin, comprising an absorption enhancer, an antimicrobial function enhancer and bound lipid removals, humectants, emollients and extracts of botanical herbs. Methods for preparing skin care compositions comprising an absorption enhancer.Type: ApplicationFiled: June 30, 2010Publication date: December 30, 2010Inventor: Zahra Mansouri
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Publication number: 20100331411Abstract: A composition, systems for dispensing the composition and methods for the use of the composition are described. The composition comprises: (A) Monohydric alcohol in an amount sufficient to provide antimicrobial activity; (B) Surfactant comprising a dimethicone surfactant; and (C) Builder, the builder in an amount sufficient to provide stability or to improve the stability of a foam formed from the composition.Type: ApplicationFiled: September 9, 2010Publication date: December 30, 2010Inventor: Robert A. Asmus
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Patent number: 7851517Abstract: A system, method and apparatus provices an antimicrobial card, badge holder or token made from an antimicrobial polymereric material. The antimicrobial polymereric material includes one or more polymers and one or more antimicrobial agents that affect the growth of bacteria, fungi, virus or a combination thereof.Type: GrantFiled: October 31, 2007Date of Patent: December 14, 2010Inventor: Lisa Marie Holmes
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Publication number: 20100303869Abstract: Superabsorbents having a coating of an antimicrobial agent are produced by a process that comprises contacting the superabsorbent with a solution comprising the anti-microbial agent and a polyol concurrently with or immediately after contacting it with the surface-crosslinking agent and prior to the curing step that completes surface crosslinking, and/or contacting the superabsorbent with a solution comprising the anti-microbial agent and polyalkylene glycol of a molecular mass between 200 and 5 000 g/mol after completion of surface crosslinking.Type: ApplicationFiled: September 12, 2008Publication date: December 2, 2010Applicant: BASF SEInventors: Michael M. Azad, James C. Robinson, Michael Young
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Patent number: 7838706Abstract: The invention disclosed a total synthesis process of novel ethoxy combretastatins and their prodrugs. Combretastatins are chemically modified by ethoxy substituted on the 4?-position of their B aryl ring and are converted to be their soluble prodrugs of phosphate or their inner salt of phosphorylcholine by modifying the hydroxyl on the 3?-position of their B aryl ring. Similarly, 3?-amino combretastatin is 4?-ethoxy chemically modified and further side chain of amino acid can be introduced to the amino to form soluble prodrug of amino acidamide. The structure of the said compound is showed as formula (I). Ethoxy combretastatins possess potent tubulin polymerization inhibitory activity and can be used for the treatment of inhibiting tumor or neovascular.Type: GrantFiled: May 16, 2007Date of Patent: November 23, 2010Assignee: Zhejiang Dade Pharmaceutical Group Co. LtdInventors: Weiping Shen, Jianping Wang, Jianguo Wang
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Publication number: 20100286285Abstract: The present invention relates to an anhydrous pharmaceutical composition for use in the treatment of psoriasis and other skin disorders, characterized in that it comprises an oleaginous ointment and, as active ingredient, a compound chosen from vitamin D and its derivatives, said active agent being in a solubilized form in said composition.Type: ApplicationFiled: November 16, 2007Publication date: November 11, 2010Applicant: GALDERMA RESEARCH & DEVELOPMENTInventors: Nathalie Barthez, Sandrine Orsoni, Laurent Fredon
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Patent number: 7820721Abstract: Agents useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, polycystic ovary syndrome, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis are disclosed.Type: GrantFiled: January 22, 2007Date of Patent: October 26, 2010Assignee: Wellstat Therapeutics CorporationInventors: Shalini Sharma, Reid W. von Borstel
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Publication number: 20100267667Abstract: The present invention is directed to use of a series of compounds and compositions comprising the same for activating telomerase and treating diseases, disorders and/or conditions related thereto.Type: ApplicationFiled: June 4, 2008Publication date: October 21, 2010Applicant: Ben-Gurion University of the Negev Research and Development AuthorityInventors: Aviv Gazit, Shimon Slavin, Esther Priel, Sara Yitzchak
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Publication number: 20100267839Abstract: The present invention implements a strategy that combines an enzyme inhibition assay with a chemical dereplication process to identify active plant extracts and the particular compounds—diarylalkanes and/or diarylalkanols within those extracts that specifically inhibit binuclear enzyme function. Included in the present invention are compositions of matter comprised of one or more of diarylalkanes and/or diarylalkanols, which inhibit the activity of binuclear enzymes, particularly tyrosinase and which prevent melanin overproduction. The present invention also provides a method for inhibiting the activity of a binuclear enzyme, particularly tyrosinase and a method for preventing and treating diseases and conditions related to binuclear enzyme function. The present invention further includes a method for preventing and treating melanin overproduction and diseases and conditions of the skin related thereto.Type: ApplicationFiled: June 11, 2010Publication date: October 21, 2010Applicant: UNIGEN PHARMACEUTICALS, INC.Inventors: Qi Jia, Ji-Fu Zhao
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Publication number: 20100267781Abstract: Methods of using apogossypol and its derivatives for treating inflammation is disclosed. Also, there is described a group of compounds having structure A, or a pharmaceutically acceptable salt, hydrate, N-oxide, or solvate thereof are provided: wherein each R is independently H, C(O)X, C(O)NHX, NH(CO)X, SO2NHX, or NHSO2X, wherein X is hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, alkylaryl, substituted alkylaryl, heterocycle, or substituted heterocycle. Compounds of group A may be used for treating various diseases or disorders, such as cancer.Type: ApplicationFiled: April 14, 2010Publication date: October 21, 2010Applicant: Burnham Institute for Medical ResearchInventor: Maurizio Pellechia
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Publication number: 20100260813Abstract: A rodenticidal mixture comprising a) 0.0015 to 99.89% by weight of at least one rodenticide, b) 10?8 to 95% by weight of at least one painkiller and c) 0.01 to 99.9984% by weight of at least one biocide, where the percentages by weight are based on the total of components (a), (b) and (c), is suitable for the preparation of rodenticidal bait formulations which are employed for controlling rodent pests.Type: ApplicationFiled: September 30, 2008Publication date: October 14, 2010Applicant: BASF SEInventors: Gerhard Schnabel, Michael Ishaque, Dieter Zeller, Lars Weichel, Andrej Brejc
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Publication number: 20100260691Abstract: An aqueous composition containing a hydrophobic material, and, more particularly, a water soluble matrix of a water soluble polymer and a water soluble surfactant, in the form of a complex, for stabilizing the hydrophobic material, as a nanoparticulate dispersion or emulsion. A delivery system for delivering bioactive hydrophobic materials as an aqueous nanoparticle dispersion of a water soluble matrix of polymer and a surfactant.Type: ApplicationFiled: May 11, 2007Publication date: October 14, 2010Inventors: Kolazi S. Narayanan, Domingo Jon, Jayanti Patel, Karen Winkowski