Plural Oxygens Patents (Class 514/723)
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Patent number: 6011071Abstract: To provide a novel ether compound which is useful such as an oil agent and a surfactant having the formula (I): R.sup.1 --O--(AO).sub.n --R.sup.2, wherein R.sup.1 is an alpha-branched alkyl group or an alkyl group having two or more branched chains or a cycloalkyl having 5 to 7 carbon atoms, R.sup.2 is an alkyl or alkenyl each being either branched or straight, each having 10 to 30 carbon atoms, A is an alkylene having 2 to 12 carbon atoms, n is a number from 0 to 30, A's being same as or different from one another.Type: GrantFiled: November 17, 1997Date of Patent: January 4, 2000Assignee: Kao CorporationInventors: Yasuyuki Fujii, Hisakazu Furugaki, Katsumi Kita, Hideharu Morimoto, Mitsuru Uno, Yasushi Kajihara
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Patent number: 5998483Abstract: Methods are provided to prepare a variety of tissues in a pathology-stable form keyed to the use of an aqueous solution of C.sub.2-6 dialdehyde and/or dialdehyde addition products, including the group consisting of glyoxal and/or glutaraldehyde in an amount sufficient to prevent autolysis and other degradative changes in various tissues. The said solution is capable of treating a tissue so as to maintain the tissue in a condition suitable for pathology and/or other experimental observation. The stabilizing solution is also useful to prepare parts or whole animals and plants in an anatomically preserved state for a prolonged period of time, and compositions useful in that method.Type: GrantFiled: December 6, 1996Date of Patent: December 7, 1999Inventor: Gerald W. Camiener
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Patent number: 5985291Abstract: A method of treating topical anti-bacterial infections which comprises the separate, simultaneous or sequential administration to a patient in need thereof an effective amount of mupirocin or a salt thereof and chlorhexidine or a salt thereof.Type: GrantFiled: November 24, 1997Date of Patent: November 16, 1999Inventor: Pieter M De Wet
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Patent number: 5955624Abstract: Alk-1-enyl glycerol derivatives and method of preparing same. The derivatives stimulate cell and tissue growth.Type: GrantFiled: June 7, 1995Date of Patent: September 21, 1999Assignee: Cell Therapeutics, Inc.Inventors: Edward Nudelman, Sen-Itiroh Hakomori
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Patent number: 5908854Abstract: Disclosed are aqueous mycobacterial concentrate compositions at a pH in the range of 6 to 12 which comprises per 100% weight of a concentrate composition:a) from about 0.1% wt. to about 25% wt. of a germicidal cationic quaternary ammonium compound;b) from about 0.25% wt. to about 25% wt. of a solvent selected from: phenoxyalcohol, glycol ethers, or mixtures thereof; and,c) water.The concentrate compositions may be used in a ready to use form, or may be further diluted with water to form a disinfecting composition therefrom. The compositions may also include an effective amount of a pH adjusting agent, such as sodium hydroxide or triethanolamine. The compositions featuring reduced amounts of active constituents than those known to the art, and are particularly effective against Mycobacteriuin terrae.Type: GrantFiled: September 12, 1997Date of Patent: June 1, 1999Assignee: Reckitt & Colman Inc.Inventors: Karen Ann McCue, Narendra Nanavati, Timothy John Taylor
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Patent number: 5906992Abstract: The present invention relates to a foam composition for killing dust mites comprising an acaricidal agent, polymer, ether solvent, perfume, surfactant and water.Type: GrantFiled: November 21, 1996Date of Patent: May 25, 1999Assignee: Colgate Palmolive CompanyInventors: Pierre Fonsny, Germaine Zocchi
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Patent number: 5885590Abstract: The present invention relates to water-in-oil and water-in-oil-in-water multiple emulsions and methods of preparation which overcome many of the limitations of previous emulsions and are superior preparations for use in numerous applications including, but not limited to, vaccine adjuvants, pharmaceuticals, cosmetics, foods, and various household and industrial uses.Type: GrantFiled: January 20, 1995Date of Patent: March 23, 1999Inventors: Robert L. Hunter, Carol Elizabeth Bennett
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Patent number: 5858401Abstract: The invention comprises a stable solution of cyclosporine forming a polar lipid self-emulsifying drug delivery system ("PLSEDDS"). The composition typically consists of cyclosporine dissolved in a polar lipid, such as a medium chain monoglyceride of C.sub.6 -C.sub.12 fatty acids having a monoglyceride content of at least 50% and a surfactant. The composition provided here instantly forms a fine emulsion on exposure to water. The encapsulated dosage form of this composition needs neither a hydrophilic component nor air-tight blister packaging, and is particularly suitable for oral administration.Type: GrantFiled: January 22, 1997Date of Patent: January 12, 1999Assignee: Sidmak Laboratories, Inc.Inventors: Vinayak T. Bhalani, Satishchandra P. Patel
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Patent number: 5859017Abstract: In a method for treating or preventing allergy or allergic disorders an effective amount of a compound that inhibits intracellular generation of phosphatidic acid and diacylglycerol is administered. The intracellular generation of phosphatidic acid and diacylglycerol results from allergen presentation or mast cell/basophil activation.Type: GrantFiled: April 1, 1994Date of Patent: January 12, 1999Assignee: Cell Therapeutics, Inc.Inventors: Elisa Eiseman, Emer Clarke, Jack W. Singer, Stuart L. Bursten
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Patent number: 5859052Abstract: Novel derivatives of fatty acid analogs that have from one to three heteroatoms in the fatty acid moiety which can be oxygen, sulfur or nitrogen, are disclosed in which the carboxy-terminus has been modified to form various amides, esters, ketones, alcohols, alcohol esters and nitrites thereof.These compounds are useful as substrates for N-myristoyltransferase (NMT) and/or its acyl coenzyme, and as anti-viral and anti-fungal agents or pro-drugs of such agents. Illustrative of the disclosed compounds are fatty acid amino acid analogs of the structure ##STR1## in which x is the ethyl or t-butyl ester of an amino acid such as Gly, L-Ala, L-Ile, L-Phe, L-Trp, L-Thr or an amide such as NHCH.sub.2 C.sub.6 H.sub.5 or NH(CH.sub.2).sub.2 C.sub.6 H.sub.5.Type: GrantFiled: March 27, 1998Date of Patent: January 12, 1999Assignee: G. D. Searle & Co.Inventors: Sean T. Nugent, Richard A. Mueller
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Patent number: 5837714Abstract: This invention provides solid pharmaceutical dispersions comprising a poorly soluble drug substance, as SR48692 or naproxen, xylitol and Transcutol, and a method of preparing such dispersions comprising the steps of dissolving the poorly soluble drug substance in Transcutol and adding the solution to xylitol. The dispersions exhibit good pharmaceutical properties and reduced levels of impurities and degradation products.Type: GrantFiled: March 3, 1997Date of Patent: November 17, 1998Assignee: SanofiInventors: William Rocco, Sharon Laughlin
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Patent number: 5824703Abstract: A method of assisting a mammal having a lung disorder to breathe ambient gas normally, i.e., without the assistance of a ventilator. The method includes providing an animal having a lung disorder, such as surfactant deficiency, stiff lung, or hyperinflated lung syndrome, and instilling a minimum effective dose of a perfluorochemical liquid or emulsion through the trachea for coating the alveolar sacs of a lung of the mammal. The preferred perfluorochemicals have a very low vapor pressure to avoid inducing hyperinflated lung syndrome and are supplied in a minimum effective dosage sufficient to coat the inner lung surfaces. The perfluorochemicals are permeable to the ambient gas and reside substantially permanently within the alveolar sacs without inducing hyperinflated lung syndrome. The liquid is instilled in an amount sufficient to enable the animal to breathe the ambient gas normally with O.sub.2 /CO.sub.2 blood gas exchange. Effective coating of the lungs with a small (generally <0.Type: GrantFiled: December 27, 1996Date of Patent: October 20, 1998Assignee: Synthetic Blood International, Inc.Inventor: Leland C. Clark, Jr.
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Patent number: 5824322Abstract: The present invention includes compositions and methods using biologically active nonionic reverse block copolymers. The reverse copolymers have an inner core of polyoxypropylene (POP) that is flanked on either end by polyoxyethylene (POE). The reverse block copolymers have the following formula: ##STR1## wherein "b" represents a number such that the molecular weight of the hydrophobe (C.sub.3 H.sub.6 O).sub.b is between approximately 2,000 and 10,000, and "a" represents a number such that the percentage of hydrophile (C.sub.2 H.sub.4 O).sub.a is between approximately 5% and 30%. The reverse block copolymers stimulate the immune response, can suppress immune responses such as those in autoimmune diseases, promote the growth of animals, and stimulate hormone production.Type: GrantFiled: August 20, 1996Date of Patent: October 20, 1998Assignee: CytRx CorporationInventor: Mannarsamy Balasubramanian
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Patent number: 5798386Abstract: There is disclosed an aqueous formulation for vascularizing ischemic or grafted tissue, comprising an alk-1-enyl glycerol derivative having the formula: ##STR1## wherein R is a straight or branched C.sub.1-24 saturated or unsaturated alkyl or a straight or branched C.sub.1-24 aryl and X and Y each is H or an saturated or unsaturated alkyl group having from 2 to 26 carbon atoms, or a monoglyceride having a C.sub.1-24 ether-linked saturated alkyl in an aqueous buffered pharmaceutical carrier.Type: GrantFiled: March 4, 1996Date of Patent: August 25, 1998Assignee: Cell Therapeutics, Inc.Inventor: Edward D. Nudelman
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Patent number: 5788958Abstract: The present invention is directed to the use of an inhibitor of NO activity, such as a nitric oxide scavenger or an NO synthase inhibitor, as an antitumor therapy to reduce tumor blood flow and oxygenation. The invention is also directed to administration of a nitric oxide scavenger or a nitric oxide synthase inhibitor to enhance the effectiveness of tumor therapy with hypoxic or acidic chemotherapeutic agents or hyperthermia. The invention is also directed to the administration of a nitric oxide synthase substrate to a subject previously administered a nitric oxide synthase inhibitor, in order to selectively inhibit tumor perfusion. In a specific example, administration of cell free hemoglobin, a nitric oxide scavenger, in conjunction with mitomycin C, a hypoxic cytotoxin, results in a significant delay in tumor growth of a human tumor xenograft in a mouse compared to mitomycin C alone.Type: GrantFiled: September 6, 1996Date of Patent: August 4, 1998Assignees: Duke University, Apex Bioscience, Inc., North Carolina State UniversityInventors: Mark W. Dewhirst, Robert E. Meyer, Joseph Bonaventura, Joseph DeAngelo
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Patent number: 5786391Abstract: For the first time, certain retinoids with a side chain terminal CH.sub.2 OH group or ester or ether thereof or aldehyde rather than a side chain terminal COOH group and substitution at the 4-position have been indicated to bind to nuclear receptors and to be biologically active in inducing cell differentiation of normal and tumor cells. These compounds activate gene expression through binding to nuclear receptor proteins. These compounds induce differentiation in normal and cancer cells and are useful for treating leukemias, and lymphomas, squamous cell carcinomas, deep (cystic) acne, psoriasis and photodamaged or aging skin. These compounds have stability and in vitro half-life advantages over and solubility differences from all-trans-retinoic acid and activity advantages over 13-cis retinoic acid.Type: GrantFiled: January 11, 1995Date of Patent: July 28, 1998Assignees: Cornell Research Foundation, Inc., The Trustees of Columbia University in the City of New YorkInventors: Lorraine J. Gudas, Charles Achkar, Jochen Buck, Alexander W. Langston, Fadila Derguini, Koji Nakanishi
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Patent number: 5783172Abstract: Compositions comprising, in an aqueous vehicle, an abrasive system containing an alkali metal bicarbonate and a surfactant system, where the surfactant system comprises a non-ionic poly(hydroxypropyl ether) surfactant. Such compositions are particularly useful as oral hygiene compositions.These compositions may be used as, or for the manufacture of, a dentifrice in the form of a paste, a gel, a liquid or a chewing gum.Type: GrantFiled: December 8, 1995Date of Patent: July 21, 1998Assignee: L'OrealInventors: Jean-Marc Ascione, Pascal Sterle
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Patent number: 5777178Abstract: The present invention is directed to a process for the preparation of polyoxyalkylene ether surfactant compositions comprising the steps of combining an admixture of alkoxylated alcohols with an acid catalyst and 1-6 molar equivalents of an aldehyde. The mixture is reacted at between about 50.degree. C. and about 180.degree. C. and at between about 1 atm and 10 atm pressure in the absence of a distillation step to produce the polyoxyalkylene ether surfactant composition.Type: GrantFiled: December 18, 1996Date of Patent: July 7, 1998Assignee: Olin CorporationInventor: Ming Shen
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Patent number: 5770199Abstract: The invention relates to a pharmaceutical preparation comprising a plasma protein wherein said preparation is free of infectious agents as well as essentially free of denaturation products and is obtainable by a method that encompasses the following steps:a) addition of a polyether and a chaotropic agent to a solution comprising the plasma protein, optional lyophilization of the solution;b) inactivation of infectious agents in the presence of the polyether by a physio-chemical or chemical treatment, andc) removal of the polyether and the chaotropic agent.Type: GrantFiled: June 28, 1996Date of Patent: June 23, 1998Assignee: Immuno AktiengesellschaftInventors: Johann Eibl, Friedrich Dorner, Noel Barrett
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Patent number: 5750094Abstract: An O/W type lipstick overcoat composition comprising (i) 2 to 80% by weight of a dimethyl polysiloxane, and/or a perfluoro polyether in an inner phase; and (ii) (a) water and (b) a silica powder and/or alumina powder in an outer phase or a W/O type lipstick overcoat composition (i) 40 to 70% by weight of a dimethyl polysiloxane in an outer phase and (ii) (a) water and (b) a silica powder and/or alumina powder in an inner phase.Type: GrantFiled: May 25, 1995Date of Patent: May 12, 1998Assignee: Shiseido Company, Ltd.Inventors: Satoshi Tomomasa, Tomiyuki Nanba, Yoshikazu Soyama
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Patent number: 5744461Abstract: Lipid-containing prodrugs are provided for treating viral infections due to herpes, influenza, hepatitis B, Epstein-Barr, and varicella zoster viruses, as well as cytomegalovirus and derivatives of antiviral agents. The compounds comprise phosphonoacids having antiviral activity which are linked, either through the phosphate group or carboxyl group of the phosphonoacid, to one of a selected group of lipids. Phosphonoacetic acid and phosphonoformic acid are thus linked to phospholipids, glycerolipids, sphingolipids, glycolipids, or fatty acids. The compounds persist, after intracellular hydrolysis, as the antiviral phosphonoacids. The lipid prodrugs are effective in improving the efficacy of antiviral phosphonoacids by prolonging their antiviral activity following administration.Type: GrantFiled: May 26, 1995Date of Patent: April 28, 1998Assignee: NeXstar Pharmaceuticals, Inc.Inventors: Karl Y. Hostetler, Raj Kumar
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Patent number: 5736574Abstract: Combinatory antimicrobial immixtures comprising at least one antimicrobial hydrolipid and/or lipid and an antimicrobially synergistically effective amount of at least one glyceryl monoalkyl ether are well suited for formulation, as preservatives, into a wide variety of pharmaceutical/cosmetic compositions.Type: GrantFiled: May 17, 1996Date of Patent: April 7, 1998Assignee: La Roche Posay Laboratoire PharmaceutiqueInventors: Veronique Burnier, Jean Pierre Brissonnet
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Patent number: 5731354Abstract: A method of inhibiting degeneration of neural cells comprising treating the cells with an effective degeneration-inhibiting amount of one or more compounds of Formula I: ##STR1## wherein R is a C.sub.12 to C.sub.22 linear or branched alkyl group, or pharmaceutically-acceptable salts thereof is disclosed.Type: GrantFiled: May 6, 1996Date of Patent: March 24, 1998Assignee: Clarion Pharmaceuticals Inc.Inventor: Thaddeus P. Pruss
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Patent number: 5719194Abstract: Use of perfluoropolyethers with non reactive terminals or compositions thereof for the prevention and/or the treatment of topical vital infections, in particular of Herpes Simplex I and II and of Herpes Zoster.Type: GrantFiled: June 7, 1996Date of Patent: February 17, 1998Assignee: Ausimont S.p.A.Inventors: Morris A. Mann, Giovanni Pantini
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Patent number: 5710183Abstract: The invention provides a composition for the improvement of bowel function comprising polyethylene glycol and, preferably, a fiber bulking agent, in, preferably, at least about equal parts by weight of polyethylene glycol; an optional wetting agent to promote solubility/dispersability of the composition in liquid medium; and an optional gas-reducing agent to counteract effects of intestinal gas production attributable to the ingestion of poorly digestible fiber. The products are quickly effective, do not compromise bowel integrity, and are suitable for long-term use in the clinical or veterinary treatment of constipation and/or diarrhea.Type: GrantFiled: July 14, 1995Date of Patent: January 20, 1998Inventor: George M. Halow
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Patent number: 5710175Abstract: Alk-1-enyl glycerol derivatives and method of preparing same. The derivatives stimulate cell and tissue growth.Type: GrantFiled: April 4, 1996Date of Patent: January 20, 1998Assignee: Cell Therapeutics, Inc.Inventors: Edward Nudelman, Sen-Itiroh Hakomori
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Patent number: 5691387Abstract: The present invention comprises novel preparations of polyoxypropylene/polyoxyethylene copolymers which retain the therapeutic activity of the commercial preparations, but are substantially free from the undesirable effects which are inherent in the prior art preparations. Because the preparations of polyoxypropylene/polyoxyethylene copolymers which comprise the present invention are a less polydisperse population of molecules than the prior an polyoxypropylene/polyoxyethylene copolymers, the biological activity of the copolymers is better defined and more predictable.Type: GrantFiled: June 3, 1996Date of Patent: November 25, 1997Assignee: CytRx CorporationInventors: R. Martin Emanuele, Robert L. Hunter, Paula H. Culbreth
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Patent number: 5674911Abstract: The present invention comprises novel preparations of polyoxypropylene/polyoxyethylene copolymers which retain the therapeutic activity of the commercial preparations, but substantially reduce the undesirable effects which are inherent in the prior art preparations. Because the preparations of polyoxypropylene/polyoxyethylene copolymers which comprise the present invention are a less polydisperse population of molecules than the prior art polyoxypropylene/polyoxyethylene copolymers, the biological activity of the copolymers is better defined and more predictable and the cardiotoxicity inherent in the native copolymers is substantially reduced.Type: GrantFiled: June 6, 1995Date of Patent: October 7, 1997Assignee: Cytrx CorporationInventors: R. Martin Emanuele, Mannarsamy Balasubramanian, Hameedsulthan S. Allaudeen
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Patent number: 5635194Abstract: Populations of black flies can be controlled by introducing an effective amount of water soluble detergent range ethoxylated alcohols into the aquatic habitats where black fly larvae are found.Type: GrantFiled: August 9, 1995Date of Patent: June 3, 1997Assignee: Shell Oil CompanyInventors: Philip B. Dorn, John H. Rodgers, Jr.
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Patent number: 5621012Abstract: Active compound combinations comprising active contents of(a) one or more glycerol ethers of saturated and/or unsaturated, branched and/or unbranched aliphatic alcohols having 12 to 24 carbon atoms,(b) bisabolol and/or panthenol(c) and if appropriate one or more substances chosen from the group consisting of cosmetically or dermatologically acceptable antioxidants.Type: GrantFiled: June 1, 1995Date of Patent: April 15, 1997Assignee: Beiersdorf AktiengesellschaftInventors: Uwe Sch onrock, Joachim Degwert, Friedhelm Steckel
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Patent number: 5607979Abstract: Creams formed from about 35% to about 50% fine particulates of certain poly(tetrafluoroethylene) (PTFE) resins dispersed in perfluorinated polyether oils having viscosities from about 20 cSt to about 350 cSt afford good protection against chemical warfare agents such as sulfur mustard (HD), lewisite (L), sulfur mustard/Lewisite mixtures (HL), pinacolyl methylphosphonofluoridate (soman or GD), thickened soman (TGD) and O-ethyl S-2-diisopropylaminoethyl methylphosphonothiolate (vx).Type: GrantFiled: May 30, 1995Date of Patent: March 4, 1997Assignee: The United States of America as represented by the Secretary of the ArmyInventor: Michael J. McCreery
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Patent number: 5554372Abstract: The present invention comprises adjuvants which, when admixed with an antigen and administered into a human or animal, will induce a more intense immune response to the antigen than when the antigen is administered alone. In many cases, the adjuvant that is described as the present invention will increase overall titer of antibodies of a specific isotype which are specific for the antigen. For example, in mice, when the adjuvant of the present invention is admixed with a conventional antigen, the isotype that is induced in the mouse is changed from a predominantly IgG1 isotype to the more protective IgG2 isotype and, in some cases, IgG3 isotype. Thus, by practicing the present invention, one can improve the overall protective effect of conventional vaccines.Type: GrantFiled: April 11, 1995Date of Patent: September 10, 1996Assignee: Emory UniversityInventor: Robert L. Hunter
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Patent number: 5539001Abstract: Antimicrobial mixtures containing specific antimicrobial diols, e.g. 1,2-dodecanediol, and specific aromatic alcohols, e.g. phenylethyl alcohol or hydrocinnamic alcohol, are provided. Such mixtures with a weight ratio of diol to aromatic alcohol of 9:1 to 1:9 have been found to exhibit a synergistic effect, i.e. a high antimicrobial activity which cannot be explained by an additive effect of the very low-activity components. Such mixtures are useful in the disinfection of hard surfaces, in the production of disinfectant cleaning preparations and in the preservation of water-based preparations of microbially degradable substances.Type: GrantFiled: February 15, 1994Date of Patent: July 23, 1996Assignee: Henkel Kommanditgesellschaft auf AktienInventors: Marianne Waldmann-Laue, Irina Slominski, Gerhard Stoll, Bernhard Meyer, Werner Schneider
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Patent number: 5529770Abstract: Improved, highly viscous film-forming protective germicidal formulations are provided which include water, a germicidal agent (preferably complexed iodine) together with an organic thickener, a skin conditioning agent and a minor amount of polyvinyl pyrrolidone. Preferably, the formulations include iodine complexed with a Poloxamer and PVP, in combination with a xanthan gum and glycerin. The formulations have a viscosity of from about 50-5000 cP and form a flexible residual film when applied to skin. The invention is particularly useful in the preparation of bovine teat dips.Type: GrantFiled: December 9, 1994Date of Patent: June 25, 1996Assignee: West Agro, Inc.Inventors: Michael D. McKinzie, Elizabeth L. Lenahan, Thomas C. Hemling
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Patent number: 5496536Abstract: Injectable contrast agents of great clinical importance for lymphography, characterized by non-water soluble particle sizes between about 5 or 10 nm and about 500 or 900 nm, which have selective distribution to lymph nodes upon percutaneous administration and can be imaged with millimeter resolution. Also disclosed are methods for performing percutaneous lymphography using these contrast agents.Type: GrantFiled: April 25, 1995Date of Patent: March 5, 1996Inventor: Gerald Wolf
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Patent number: 5455278Abstract: A method of inhibiting gram-positive bacteria in a medium, such as food, comprises adding to the medium an effective amount of an inhibitor from carrots or a derivative thereof. Compositions and products containing such an inhibitor are also disclosed.Type: GrantFiled: September 19, 1994Date of Patent: October 3, 1995Assignee: Wisconsin Alumni Research FoundationInventors: June F. M. Parreiras, Eric A. Johnson
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Patent number: 5446033Abstract: Solutions of alkylphosphocholines in glycerol alkyl ethers having enhanced storage stability containing a buffer which maintains the pH value to a range between 4 and 6.Type: GrantFiled: October 19, 1993Date of Patent: August 29, 1995Assignee: Asta Medica AGInventors: Jurgen Engel, Elisabeth Wolf-Heuss, Helmut Orth, Burkhard Wichert, Dieter Sauerbier
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Patent number: 5444094Abstract: Efficacious aldehyde-free tuberculocidal liquid compositions which are odorless, less-toxic, and essentially irritant-free are disclosed. These compositions consist of a solvent containing a glycol ether and a quaternary ammonium salt and can be used in a method to disinfect and sanitize a variety of surfaces.Type: GrantFiled: August 24, 1993Date of Patent: August 22, 1995Assignee: Stepan CompanyInventors: Arshad Malik, Thomas W. Isaac
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Patent number: 5432147Abstract: The present invention provides a method for controlling fungal disease in cultivated crops. The aqueous fungicide formulation which is applied to pre-harvest and post-harvest crops contains ingredients which are biocompatible for purposes of agricultural and horticultural applications. Illustrative of a formulation which is harmless to animals and humans is an aqueous solution having a content of potassium bicarbonate, potassium carbonate, nonionic surfactant and xanthan gum. The combination of nonionic surfactant and xanthan gum functions as an effective spreader-sticker medium for forming a film-like coating on plant surfaces. The adherent coating exhibits both immediate and long duration fungicidal activities.Type: GrantFiled: October 19, 1994Date of Patent: July 11, 1995Assignee: Church & Dwight Co., Inc.Inventors: Anthony E. Winston, Alfredo Vinci
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Patent number: 5427795Abstract: New solid formulations ofA) at least one agrochemical active compound,B) at least one additive from the groups mentioned in the description,C) at least one dispersant,D) at least one carrier andE) if appropriate, further active compounds and/or additives,a process for preparing the solid formulations and their use for treating plants.A new device for preparing new granules.Type: GrantFiled: March 22, 1993Date of Patent: June 27, 1995Assignee: Bayer AktiengesellschaftInventors: Peter Feyen, Uwe Priesnitz, Raphael Weischollek, Wolfgang Thielert, Stefan Dutzmann, Dieter Feucht, Ulrike Wachendorff-Neumann
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Patent number: 5389386Abstract: The present invention provides a method for controlling fungal disease in cultivated crops. The aqueous fungicide formulation which is applied to pre-harvest and post-harvest crops contains ingredients which are biocompatible for purposes of agricultural and horticultural applications. Illustrative of a formulation which is harmless to animals and humans is an aqueous solution having a content of potassium bicarbonate, potassium carbonate, nonionic surfactant and xanthan gum. The combination of nonionic surfactant and xanthan gum functions as an effective spreader-sticker medium for forming a film-like coating on plant surfaces. The adherent coating exhibits both immediate and long duration fungicidal activities.Type: GrantFiled: June 30, 1994Date of Patent: February 14, 1995Assignee: Church & Dwight Co., Inc.Inventors: Anthony E. Winston, Alfredo Vinci
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Patent number: 5334615Abstract: A composition embraces an oil, for instance, a mineral oil, animal oil, or plant or vegetable oil, in combination with an acetal that can release aldehyde functionality on aqueous contact. It may be used in a method for kill or control of bacterium or virus for a suitable part of a human being or animal subject. For example, a 5% mineral oil and 2,2'-trimethylenebis(1,3-dioxolane) mixture can be used as a microbiocidal lubricant for drill bits in dentistry, or a suitably formulated composition may be used topically.Type: GrantFiled: December 17, 1992Date of Patent: August 2, 1994Inventor: Wilhelm E. Walles
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Patent number: 5230892Abstract: New solid formulations ofA) at least one agrochemical active compound,B) at least one additive from the groups mentioned in the description,C) at least one dispersant,D) at least one carrier andE) if appropriate, further active compounds and/or additives,a process for preparing the solid formulations and their use for treating plants.A new device for preparing new granules.Type: GrantFiled: July 10, 1992Date of Patent: July 27, 1993Assignee: Bayer AktiengesellschaftInventors: Peter Feyen, Uwe Priesnitz, Raphael Wieschollek, Wolfgang Thielert, Stefan Dutzmann, Dieter Feucht, Ulrike Wachendorff-Neumann
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Patent number: 5223515Abstract: An injectable solution of a compound useful as an anti-ulcer agent of the formula; ##STR1## wherein R.sup.1 represents hydrogen, methoxy or trifluoromethyl group; R.sup.2 and R.sup.3, being the same as or different from each other, represent hydrogen or methyl group; and R.sup.4 represents a fluorinated C.sub.2 to C.sub.5 lower alkyl group, is provided by dissolving the compound in at least one of ethanol, propylene glycol and polyethylene glycol; or by dissolving the freeze-dried material of an alkaline aqueous solution of the compound in a mixture of an acidic substance and at least one of the above solvents.Type: GrantFiled: August 4, 1992Date of Patent: June 29, 1993Assignee: Takeda Chemical Industries, Ltd.Inventors: Yasushi Mikura, Akihiro Nagai, Hisayoshi Shimizu
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Patent number: 5183588Abstract: The invention consists in a ternary system.The ternary system comprises three phases which are non-miscible with one another and consist of a phase of perfluorinated ethers, an aqueous phase and a phase of silicones comprising at least one straight-chain-silicone containing a glycol group and at least one cyclic-chain silicone containing a methyl group. These silicones can be of the dimethicone copolyol type and of the cyclomethicone type, respectively. And the aqueous phase preferably contains a hydrating agent, a co-emulsifier and an anti-bacterial preservative. The invention concerns in particular cosmetics.Type: GrantFiled: April 4, 1990Date of Patent: February 2, 1993Assignee: Yves Saint Laurent ParfumsInventors: Martine S. Salerno, Remy Mounier, Bernard Breda
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Patent number: 5173511Abstract: A method for treating a patient to effect the remission of disorders associated with allergies, particularly asthma, by administering to the patient in need of such treatment a glycerol ether in a therapeutically effective amount sufficient to cause remission of such discomfort.Type: GrantFiled: November 29, 1990Date of Patent: December 22, 1992Assignee: Halsoprodukter Lars Karnerud ABInventors: Sven Brohult, Astrid Brohult
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Patent number: 5152979Abstract: In accordance with the present invention, a method is provided for treating ischemia resulting from microvascular compromise caused by abnormal cells in the blood stream, which is often a complication of malaria and leukemia. The method is especially useful for treating cerebral malaria. The method comprises administering to an animal or human with the microvascular compromise a therapeutically effective amount of a surface active copolymer with the following general formula:HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b Hwherein a is an integer such that the hydrophobe represented by (C.sub.3 H.sub.6 O) has a molecular weight of approximately 950 to 4000 daltons, preferably about 1200 to 3500 daltons, and b is an integer such that the hydrophile portion represented by (C.sub.2 H.sub.4 O) constitutes approximately 50% to 90% by weight of the copolymer.Type: GrantFiled: August 14, 1991Date of Patent: October 6, 1992Assignee: Emory UniversityInventor: Robert L. Hunter
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Patent number: 5149706Abstract: A germicidal composition is disclosed which comprises a solvent containing at least 50% by weight of a stabilizing liquid selected from 3-methyl-3-methoxybutyl alcohol and an isothiazolone compound dissolved in the solvent.Type: GrantFiled: July 2, 1990Date of Patent: September 22, 1992Assignee: Somar CorporationInventors: Ryoji Funatsu, Susumu Mitsui, Shigeru Kurose, Atsuko Gato
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Patent number: 5143939Abstract: This invention relates to the discovery that a very particular kind of nonionic surfactant, namely an alkyloxypolyethyleneoxyethanol can be used as the sole active ingredient to control fungus, mites, worms, termites, nematodes and other insects. It is believed that these alkyloxypolyethyleneoxyethanols can be represented by the formula: ##STR1## wherein n is from 9 to 15 and m is from 3 to 40.Type: GrantFiled: June 21, 1991Date of Patent: September 1, 1992Inventor: Henry A. Browning
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Patent number: 5141963Abstract: This invention relates to the discovery that a very particular kind of nonionic surfactant, namely an alkyloxypolyethyleneoxyethanol can be used as the sole active ingredient to control ticks and other insect pests. It is believed that these alkyloxypolyethyleneoxyethanols can be represented by the formula: ##STR1## wherein n is from 9 to 15 and m is from 3 to 40.Type: GrantFiled: June 21, 1991Date of Patent: August 25, 1992Inventor: Henry A. Browning