Nuclear Halogenated Patents (Class 514/737)
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Patent number: 6730329Abstract: One aspect of the invention relates to anti-viral composition containing at least one zinc compound and at least one phenolic antioxidant (and optionally other ingredients such as at least one analgesic) at least one hydrocarbyl containing compound, and water. Another aspect of the invention relates to a method of treating lesionous symptoms of a viral infection involving applying an effective amount of the zinc containing anti-viral composition to the lesions.Type: GrantFiled: February 26, 2002Date of Patent: May 4, 2004Inventor: Jeffrey B. Smith
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Patent number: 6730294Abstract: A method of forming a water soluble biocidal film on a solid household, food preparation, or medical surface, which protects the solid surface against reinfection by microorganisms, includes providing a liquid biocidal composition comprised of, based on total weight of the liquid biocidal composition from 0.1 to 5.0 wt. % of a phenolic biocide; from an amount effective to impart film-forming properties to the liquid biocidal composition up to 8 wt. % of a polyvinyl pyrrolidone polymer or copolymer; and an aqueous alcoholic solvent in which the phenolic biocide and the polyvinylpyrrolidone polymer or copolymer are dissolved; treating the solid surface with the liquid biocidal composition; and evaporating the aqueous alcoholic solvent to provide a clear film, wherein a ratio of the phenolic biocide to the polyvinylpyrrolidone polymer or copolymer is selected to range from 1:0.8 to 1:3 so that a complex there between is provided which dries clear.Type: GrantFiled: March 31, 2000Date of Patent: May 4, 2004Assignee: Novapharm Research (Australia) Pty LimitedInventor: Steven Kritzler
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Publication number: 20040047807Abstract: The present invention relates to the use of neurotoxic substances, which have a toxic effect in particular for the axon and the nociceptive nerve endings, for the preparation of an agent for the treatment of joint pain.Type: ApplicationFiled: August 11, 2003Publication date: March 11, 2004Inventor: Dominik Meyer
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Publication number: 20040023939Abstract: The present invention discloses an aqueous phenolates-containing liquid formulation having a solidification point of less than or equal to −10° C.Type: ApplicationFiled: June 9, 2003Publication date: February 5, 2004Inventors: Matthias Buri, Patrick Schwarzentruber
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Publication number: 20030176513Abstract: The present invention relates to the synthesis of fluorinated forms of alkyl phenol compounds and their subsequent use as pharmaceutical agents. More specifically, alkyl phenol compounds are fluorinated to increase compound volatility such that the compound may be administered to a mammal, such as a human being, by inhalation. The invention also provides an inhaler (or vaporizer), that can be used for administration of the volatile derivatives of fluorine-substituted alkyl phenol compound. Further, different derivatives of fluorine-substituted alkyl phenol compound can be also administered by other routes as described in this document.Type: ApplicationFiled: March 12, 2002Publication date: September 18, 2003Inventors: Max T. Baker, Mohamed Naguib
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Patent number: 6503952Abstract: An antimicrobial composition comprising (i) between 0.025 and 2 percent of an antimicrobial agent selected from the group consisting of chlorhexidine free base, a chlorhexidine salt, polyhexamethylene biguanide, and alexidine; (ii) between 0.005 and 0.1 percent of a quaternary ammonium compound; and (iii) between 0.025 and 2 percent of a chlorinated phenol compound.Type: GrantFiled: January 11, 2001Date of Patent: January 7, 2003Assignee: The Trustees of Columbia University in the City of New YorkInventors: Shanta Modak, Lester Sampath, Lauserpina A. Caraos
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Patent number: 6475526Abstract: One aspect of the invention relates to anti-viral composition containing at least one zinc compound and at least one phenolic antioxidant (and optionally other ingredients such as at least one analgesic) at least one hydrocarbyl containing compound, and water. Another aspect of the invention relates to a method of treating lesionous symptoms of a viral infection involving applying an effective amount of the zinc containing anti-viral composition to the lesions.Type: GrantFiled: June 5, 2001Date of Patent: November 5, 2002Inventor: Jeffrey B. Smith
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Publication number: 20020106413Abstract: Plastic films, fibers and articles are provided long-term antimicrobial activity with a combination of certain phenolic and inorganic antimicrobial agents. The plastic films, fibers and articles with antimicrobial activity exhibit superior resistance to discoloration, may be processed at high temperature, and maintain physical properties upon weathering, especially upon exposure to ultraviolet radiation.Type: ApplicationFiled: September 21, 2001Publication date: August 8, 2002Inventors: Heinz Herbst, Urs Stadler
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Patent number: 6426093Abstract: A biocidal composition composed of a ternary complex of a negatively-charged biocide, a transition metal ion and chelator has synergistic biocidal effects as compared with a composition of each of the components alone. The chelator is preferably a neutral or positively-charged chelator. The ternary complex may be used for killing or inhibiting the growth of living cells.Type: GrantFiled: February 9, 1999Date of Patent: July 30, 2002Assignee: Yissum Research Development Company of the Hebrew University of JerusalemInventors: Mordechai Chevion, Benzhan Zhu, Svetlana Schechtman
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Patent number: 6391925Abstract: A liquid composition of phenolic compounds can be formed in the substantial absence of a solvent and a surfactant. This composition includes at least one substituted phenol and a halo-substituted phenol. In one embodiment, the composition includes benzylchlorophenol and at least one of phenylphenol and tert-pentylphenol. In another embodiment, the composition includes benzylchlorophenol, phenylphenol, and tert-pentylphenol. The composition may be useful for preparing an antimicrobial material. A liquid phenolic composition can be prepared by forming a composition having at least one substituted phenol and a halo-substituted phenol in the substantial absence of a solvent and surfactant and mixing the composition until a liquid phenolic composition is formed.Type: GrantFiled: January 13, 2000Date of Patent: May 21, 2002Assignee: Ecolab Inc.Inventor: Kim R. Smith
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Patent number: 6335004Abstract: Reduced odor or odorless antimicrobial phenolic compositions containing collagen amino acids and methods of use are disclosed. The compositions can be formulated for use as a soap, emollient or hard surface cleaner. In one particularly advantageous embodiment, a composition of the invention is formulated as an antimicribial cleaner including an amount of collagen amino acids sufficient to decrease the odor of the phenolic compound below its initial levels and an amount of at least one of a soap or hard surface cleaner.Type: GrantFiled: May 31, 2000Date of Patent: January 1, 2002Assignee: Ecolab Inc.Inventor: Kim R. Smith
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Patent number: 6103768Abstract: The invention described here concerns the unique utility of fatty acids and their derivatives to eradicate existing fungal and bacterial infections in plants. Also, described herein are combination treatments whereby fatty acids are used to enhance or augment the activity of fungicides, bactericides, and biological control agents.Type: GrantFiled: September 8, 1997Date of Patent: August 15, 2000Assignee: Mycogen CorporationInventors: Steven D. Savage, Steven L. Evans, Robert A. Haygood, Paul S. Zorner, Keith Jones
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Patent number: 6099849Abstract: Methods of using absorption enhancer as a component of skin care compositions for moisturizing and protecting the skin. Antimicrobial skin care compositions for cleansing and moisturizing the skin, comprising an absorption enhancer, an antimicrobial function enhancer and bound lipid removals, humectants, emollients and extracts of botanical herbs. Methods for preparing skin care compositions comprising an absorption enhancer.Type: GrantFiled: February 19, 1998Date of Patent: August 8, 2000Inventor: Zari Mansouri
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Patent number: 6034081Abstract: A method for increasing the effectiveness of a microbicide is described, wherein a microbicide and an N-alkyl heterocyclic compound are applied to a substrate or aqueous system subject to the growth of microorganisms. The N-alkyl heterocyclic compound is applied in an amount effective to increase the microbicidal activity of the microbicide. The N-alkyl heterocyclic compound has the formula: ##STR1## The variable "In" ranges from 5 to 17, and the heterocyclic ring defined by ##STR2## is a substituted or unsubstituted ring having four to eight members. Microbicidal compositions are described where the microbicide and the N-alkyl heterocyclic compound are present in a combined amount effective to control the growth of at least one microorganism. Methods for controlling the growth of microorganisms on various substrates and in various aqueous systems are also described.Type: GrantFiled: May 30, 1995Date of Patent: March 7, 2000Assignee: Buckman Laboratories International IncInventors: Marilyn S. Whittemore, Daniel E. Glover, S. Rao Rayudu
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Patent number: 6008259Abstract: Described is the use of microbicidal phenolic compounds in combination with glutaraldehyde for the preparation of disinfectants which are suitable for the disinfection of surfaces and instruments, but also of parts of the body (for example hands) in hospitals and doctors' surgeries.Type: GrantFiled: April 17, 1997Date of Patent: December 28, 1999Assignee: Bayer AktiengesellschaftInventors: Otto Exner, Manfred Hoffmann
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Patent number: 5985937Abstract: The method of treating a leukotriene-mediated disease which is treatable by inhibition of 5-lipoxygenase includes administering a therapeutically effective amount of 2,4,6-triiodophenol, or a pharmaceutically acceptable salt or solvate thereof, for 5-lipoxygenase inhibition, together with an adequate amount of pharmaceutically acceptable excipients, diluents or carriers to the patient suffering from the disease. The diseases treated advantageously include, among others, herpes and gastrointestinal, respiratory, skin and/or ocular inflammatory diseases.Type: GrantFiled: December 23, 1997Date of Patent: November 16, 1999Assignee: Bobel 246 S.L.Inventors: Joaquin Bonal de Falgas, Lorenzo Lopez Belmonte, Luis Vila Navarro, Antonio Maria Molins Pujol, Luis Lacoma Novales
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Patent number: 5866605Abstract: Pharmaceutical compositions and a method are disclosed for providing neuroprotective effect to the mammalian eye by administering to the mammalian eye the pharmaceutical composition of the invention which contains, as the active ingredient, one or more compounds having chloride channel blocking activity. Examples of chloride channel blockers utilized in the pharmaceutical composition and method of treatment are: ##STR1## wherein R is hydrogen or a pharmaceutically-acceptable cation, e.g. an alkali or alkaline earth metal, or a quaternary amine; or R represents a ester-forming moiety, e.g. a lower alkyl radical, having up to six carbon 20 atoms, that may be derived from a lower alkanol.Type: GrantFiled: December 29, 1997Date of Patent: February 2, 1999Assignee: AllerganInventors: Joseph S. Adorante, Elizabeth WoldeMussie, Guadalupe Ruiz
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Patent number: 5840765Abstract: A method of removal or retardation of growth of hair on the human body by application of phenol, a phenol derivative or a combination of at least two from the group of phenol and phenol derivatives. The element or combination is in the form of a liquid or paste and is applied to the skin and thereafter removed by cleansing. Hair growth is thereafter retarded or eliminated.Type: GrantFiled: August 4, 1997Date of Patent: November 24, 1998Inventor: Ethel Miller
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Patent number: 5714142Abstract: Compositions and methods are provided for increasing the serum half-life of a pharmacologically active agent. The novel compositions are covalent conjugates of the selected pharmacologically active agent and a transthyretin-binding ligand such as tetraiiodothyroacetic acid, 2,4,6-triiodophenol, flufenamic acid, or the like.Type: GrantFiled: June 13, 1996Date of Patent: February 3, 1998Inventors: Jeffrey M. Blaney, Fred Cohen
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Patent number: 5705530Abstract: Pharmaceutical compositions and a method are disclosed for treating glaucoma and/or ocular hypertension in the mammalian eye by administering to the mammalian eye the pharmaceutical composition of the invention which contains, as the active ingredient, one or more compounds having chloride channel blocking activity. Examples of chloride channel blockers utilized in the pharmaceutical composition and method of treatment are: ##STR1## wherein R is hydrogen or a pharmaceutically-acceptable cation, e.g. an alkali or alkaline earth metal, or a quaternary amine; or R represents a ester-forming moiety, e.g. a lower alkyl radical, having up to six carbon atoms, that may be derived from a lower alkanol.Type: GrantFiled: September 23, 1996Date of Patent: January 6, 1998Assignee: AllerganInventors: Joseph S. Adorante, Elizabeth WoldeMussie, Guadalupe Ruiz
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Patent number: 5705532Abstract: The present invention relates to antimicrobial compositions comprising (i) less than or equal to two percent by weight chlorhexidine or chlorhexidine salt; (ii) less than or equal to 0.1 percent by weight of a quaternary ammonium compound such as benzalkonium chloride; and (iii) less than or equal to two percent by weight of parachlorometaxylenol. The antimicrobial compositions of the invention may be utilized in antimicrobial detergents, soaps, creams, rinses, and emulsions for use in the medical community as well as general public use.Type: GrantFiled: November 13, 1995Date of Patent: January 6, 1998Assignee: The Trustees of Columbia University of The City of New YorkInventors: Shanta Modak, Lester Sampath
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Patent number: 5696170Abstract: Described is the use of microbicidal phenolic compounds in combination with glutaraldehyde for the preparation of disinfectants which are suitable for the disinfection of surfaces and instruments, but also of parts of the body, in hospitals and doctors' surgeries.Type: GrantFiled: November 21, 1995Date of Patent: December 9, 1997Assignee: Bayer AktiengesellschaftInventors: Otto Exner, Manfred Hoffmann
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Patent number: 5599561Abstract: A method of making poultice by mixing together water, fine mineral powder, vinegar, herbal liniment solution, and hydrated magnesium sulfate (also known as Epsom salt) to produce a poultice capable of being applied to muscles, joints, or both which may be sore, injured, or both.Type: GrantFiled: August 4, 1995Date of Patent: February 4, 1997Inventor: Angel Gonzalez, Jr.
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Patent number: 5585403Abstract: A sterilizing agent comprising:(A) a dichlorobenzene; and(B) a dialkyldimethylammonium halide represented by the formula ##STR1## wherein X is bromine or chlorine, and,R.sub.1 and R.sub.2 each independently represent an alkyl group.Type: GrantFiled: February 5, 1995Date of Patent: December 17, 1996Assignee: Tamura Seiyaku Kabushiki KaishaInventors: Reiji Seki, Ryoji Kamimura, Satoru Mitsubayashi
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Patent number: 5559151Abstract: Pharmaceutical compositions and a method are disclosed for treating glaucoma and/or ocular hypertension in the mammalian eye by administering to the mammalian eye the pharmaceutical composition of the invention which contains, as the active ingredient, one or more compounds having chloride channel blocking activity. Examples of chloride channel blockers utilized in the pharmaceutical composition and method of treatment are: ##STR1## wherein R is hydrogen or a pharmaceutically-acceptable cation, e.g. an alkali or alkaline earth metal, or a quaternary amine; or R represents a ester-forming moiety, e.g. a lower alkyl radical, having up to six carbon atoms, that may be derived from a lower alkanol.Type: GrantFiled: November 30, 1994Date of Patent: September 24, 1996Assignee: AllerganInventors: Joseph S. Adorante, Elizabeth WoldeMussie, Guadalupe Ruiz
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Patent number: 5403864Abstract: A rapidly-acting topically applied antimicrobial composition is disclosed which comprises triclosan, chloroxylenol, and an alcohol or alcohol mixture.Type: GrantFiled: April 1, 1993Date of Patent: April 4, 1995Assignee: John A. Manfuso, Jr.Inventors: Mary Ruth K. Bruch, Donna B. Suchmann
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Patent number: 5290546Abstract: The present invention provides a cordless thermal vaporizer of the liquid type wherein the body of the vaporizer has a heater for heating a wick for drawing up a chemical solution from a bottle, and a socket disposed under the heater and removably fittable in the form of a cap to the bottle for attachment thereto. The body is reduced in weight and thereby made attachable to an electric outlet with stability. The solution bottle can be attached directly to the socket of the body and is therefore easy to replace.Type: GrantFiled: September 9, 1992Date of Patent: March 1, 1994Assignee: Earth Chemical Co., Ltd.Inventors: Takahiro Hasegawa, Takanobu Kashihara, Junichiro Mesaki, Akira Nishimura
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Patent number: 5246913Abstract: This invention relates to synergistic antimicrobial and biocidal compositions comprising 5-chloro-2-methyl-4-isothiazolin-3-one and 2-methyl-4-isothiazolin-3-one and one or more commercial biocides for more effective, and broader control of microorganisms in various industrial systems.Type: GrantFiled: October 30, 1992Date of Patent: September 21, 1993Assignee: Rohm and Haas CompanyInventor: Jemin C. Hsu
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Patent number: 5190932Abstract: The invention relates to the use of water-soluble polymers containing chemically bonded tertiary and/or quaternary ammonium groups as auxiliaries for formulating microbicides, the microbicide formulations prepared using these water-soluble polymers and the use of these formulations for preserving industrial materials.Type: GrantFiled: July 11, 1990Date of Patent: March 2, 1993Assignee: Bayer AktiengesellschaftInventors: Rolf Dhein, Lothar Backer, Otto Exner, Walter Radt, Ingrid Radt, Christian Radt, Hans G. Schmitt
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Patent number: 5157045Abstract: Synergistic microbicidal compositions are disclosed, comprising 4,5-dichloro-2-cyclohexyl-3-isothizolone and one or more known microbicides for more effective, and broader control of microorganisms in various systems.Type: GrantFiled: December 10, 1990Date of Patent: October 20, 1992Assignee: Rohm and Haas CompanyInventor: Jemin C. Hsu
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Patent number: 5154920Abstract: Liquid disinfectant compositions are disclosed which can be used to surface-coat substrates with polymeric films which are adherent, water-resistant and which can impart prolonged germicidal properties to the treated surfaces.Type: GrantFiled: October 21, 1987Date of Patent: October 13, 1992Assignee: Ecolab Inc.Inventors: Daniel J. Flesher, Robert T. Hall, Richard C. Chromecek, Michael C. Braun
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Patent number: 5149526Abstract: Compositions, methods and apparatus provide for the control of Ixodid hard tick populations. The compositions comprise a cholesteryl ester and 2,6-dichlorophenol. In combination, these compounds attract and induce mating behavior in male ticks thus disrupting normal mating, with subsequent reduction in tick populations.Type: GrantFiled: November 9, 1990Date of Patent: September 22, 1992Assignee: The United States of America as represented by the Secretary of AgricultureInventors: Daniel E. Sonenshine, J. Gordon Hamilton, William R. Lusby
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Patent number: 5114978Abstract: A composition, or an aqueous mixture containing a composition of a substantially anhydrous blends of parachlorometaxylenol, fatty acid diethanolamides, and anionic surfactants of the class diethanolammonium alkylpolyoxyethyl sulfate and method for making such compositions. The compositions and solutions containing the composition have antimicrobial and cleansing properties.Type: GrantFiled: October 15, 1990Date of Patent: May 19, 1992Assignee: Rhone-Poulenc Surfactants and Specialties, L.P.Inventors: Mike E. Corti, Richard R. Tenore
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Patent number: 5030659Abstract: Liquid, aqueous disinfectant preparations containing a combination of(a) at least one microbicidal quaternary ammonium compound(b) at least one microbicidal biguanide compound and(c) at least one microbicidal phenolic compound,components (a) and (b) being present in a ratio by weight a:b of (16 - 2); 1 while components (a) and (c) are present in a ratio by weight a:c of (16 - 2):1.Type: GrantFiled: February 8, 1990Date of Patent: July 9, 1991Assignee: Henkel Kommanditgesellschaft auf AktienInventors: Klaus Bansemir, Karlheinz Disch, Klaus Hachmann
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Patent number: 5001152Abstract: The invention is concerned with the new use of known catechol derivatives of the formula ##STR1## wherein R.sub.1 and R.sub.2 are each hydrogen, alkyl having 1 to 4 carbon atoms or alkanoyl having 2 to 5 carbon atoms; X is nitro, halogen or cyano and R.sub.3 is chlorine, nitro, cyano or a radical of the formula ##STR2## wherein R.sub.4 is hydrogen, cyano, alkyl having 1 to 4 carbon atoms or alkanoyl having 2 to 5 carbon atoms and R.sub.5 is cyano, alkanoyl having 2 to 5 carbon atoms, hydroxyalkyl having 1 to 4 carbon atoms, carboxyl or phenylcarbonyl unsubstituted or substituted with one to three methoxy groups or pharmaceutically acceptable salt thereof. The new use is the treatment and prophylaxis of ulcers and lesions in the gastrointestinal tract.Type: GrantFiled: December 23, 1988Date of Patent: March 19, 1991Assignee: Orion Corporation Ltd.Inventors: Paivi A. Aho, Pentti Pohto, Inge-Britt Y. Linden, Reijo J. Backstrom, Erkki J. Honkanen, Erkki A. O. Nissenen
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Patent number: 4983618Abstract: 2-(thiocyanomethylthio) benzothiazole and at least one tri-halogenated phenol, preferably 2,4,6-tribromophenol, are used, preferably in synergistic amounts, to control microbiological growth.Type: GrantFiled: July 14, 1989Date of Patent: January 8, 1991Assignee: Buckman Laboratories International, Inc.Inventors: Miguel L. Pulido, Juan M. Ayzaguer
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Patent number: 4777166Abstract: This invention relates to various compositions, comprising a 2-acetylprid thiosemicarbazone and a diol, which are useful in the treatment of viral infections.Type: GrantFiled: March 31, 1986Date of Patent: October 11, 1988Assignees: The United States of America as represented by the Secretary of the Army, The Regents of The University of MichiganInventors: Sandra H. Smith, John C. Drach, Gordon L. Flynn
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Patent number: 4727089Abstract: A method for treating a patient suffering from muscular or joint diseases caused by inflammation comprising the steps of administering to the patient a therapeutically effective amount of a composition comprising 2,4,6-triiodophenol or the pharmacologically acceptable salts thereof, in combination with a pharmaceutically acceptable carrier.Type: GrantFiled: March 26, 1987Date of Patent: February 23, 1988Assignee: Bislak, S.A.Inventor: Jorge C. Roquet-Jalmar
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Patent number: 4727090Abstract: A method of treating a patient suffering from circulatory cardiovascular diseases which comprises the administration of a therapeutically effective amount of a composition comprising 2,4,6-triiodophenol or pharmacologically acceptable addition salts thereof, in combination with a pharmaceutically acceptable carrier to the patient.Type: GrantFiled: March 26, 1987Date of Patent: February 23, 1988Assignee: Bislak, S.A.Inventor: Jorge C. Roquet-Jalmar
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Patent number: 4677124Abstract: Pharmaceutical compositions containing 2,4,6-triiodophenol are useful for treating a variety of medical conditions, for example, atherosclerosis.Type: GrantFiled: December 12, 1984Date of Patent: June 30, 1987Assignee: Bislak, S.A.Inventor: Jorge C. Roquet-Jalmar
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Patent number: 4668419Abstract: Aqueous concentrates and soaking solutions effective to clean and deodorize feet, and to protect them from fungal infections are disclosed. The compositions comprise a phenolic antifungal compound and a terpenic oil which are dissolved or dispersed in water by means of two foam-producing nonionic surfactants and a fatty acid salt.Type: GrantFiled: May 2, 1986Date of Patent: May 26, 1987Inventor: Roger E. Moseman
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Patent number: 4596798Abstract: This invention relates to the use of various 2-acetylpyridine thiosemicarbazones which are substituted on the 4-nitrogen atom in the treatment of viral infections. Also disclosed are several synthetic procedures used to prepare the thiosemicarbazones.Type: GrantFiled: March 30, 1982Date of Patent: June 24, 1986Assignee: The United States of America as represented by the Secretary of the ArmyInventors: Charles Shipman, Jr., Daniel L. Klayman, Sandra H. Smith, John C. Drach