Abstract: A hair revitalizing tonic composition comprising (i) an amine oxide and (ii) a compound having a calmodulin inhibitory activity and/or a compound having an activity as a calcium antagonist.

Abstract: Disclosed are total parenteral nutrition formulations which include essential amino acids in combination with either arginine or ornithine, for use in detection of recurrent malignant disease in patients. Such formulations stimulate tumor-specific polyamine production to a greater extent than non-tumor related polyamine production. Additionally, such formulations were found to specifically promote an increase in red block cell putrescine levels of tumor-bearing rats. Nontumor-bearing rats were not found to be similarly reactive to these formulations. Methods for making and administering these formulations as well as their use in preventing DFMO-induced toxicity are also disclosed.The present invention also comprises formulations for use in the rejuvinati oBACKGROUND OF THE INVENTIONThe government may own certain rights in the present invention pursuant to NCI grant RDI CA3 4-465 and NCI grant ROI CA3 4-465.

Abstract: Methods and compositions for enhancing magnetic resonance imaging in at least a portion of a warm-blooded animal.

Abstract: This invention relates to a method for administering systemically active agents including therapeutic agents through the skin or mucosal membranes of humans and animals and into the blood stream in a transdermal device or formulation comprising topically administering with said systemic agent an effective amount of a membrane penetration enhancer being a carboxylic acid derivative or a salt thereof represented in one embodiment by the general formula ##STR1## wherein W represents oxygen, sulfur, or two hydrogen radicals; wherein Z represents oxygen, sulfur, or --CH.sub.2 --;wherein R represents alkyl optionally substituted with one to three double or triple bonds, --SR'", --OR'", --NHR'", --CH.sub.3, or COOR.sub.1, and wherein R.sub.1 represents hydrogen or lower alkyl;wherein R'" represents alkyl, alkylthioalkyl, alkoxyalkyl, substituted aminoalkyl, optionally substituted with a phenyl, benzoyl or heterocyclic group;wherein R' represents hydrogen, alkyl, alkoxy, acyloxy, alkylthio, hydroxy, --(CH.sub.2).sub.

Abstract: A bromo-nitro compound of the general formula ##STR1## where R, R.sup.1 and R.sup.2 can be hydrogen, or a hydrocarbyl group and R can also be R.sup.3 CO or R.sup.3 NHCO and n has a value of at least one. R and R.sup.1 can both be hydrogen. The value of n is typically one. Compounds of this type have anti-microbial properties, expecially anti-bacterial properties. The compounds can be used as industrial biocides, especially in water treatment.

Abstract: Therapeutic product based on an organic derivative of silicon, particularly useful in the treatment of vascular diseases. The organic silicon compound is associated with a polyamine carrying hydrocarbon chains including carboxyl groups.

Abstract: A method for the treatment of nematodes includes the impregnation of soil with a nematicidal amount of bromonitromethane. The application is made at rates of 1 to 40 quarts of bromonitromethane per acre of soil. The bromonitromethane has excellent nematicidal effect at surprisingly low concentrations, is cost effective, and is not phytotoxic. The bromonitromethane may be suspended in a variety of liquid or solid carrier systems, and is applied to the soil by methods including mixing, fumigation and injection.

Abstract: A stable, injectable pharmaceutical composition of vinca dimer salts. The compositions are in the form of an aqueous solution comprising per 1 ml of solution:from about 0.2 to about 2 mg of one or more pharmaceutically acceptable vinca dimer salts;from about 0.1 to about 1.0 mg of a pharmaceutically acceptable ethylenediamine-tetraacetic acid (EDTA) salt;acetate buffer in an amount necessary to maintain said aqueous solution at a pH of from about 3.0 to about 5.5; andfrom about 1.5 to about 2.5 mg of a preservative selected from methyl paraben, propyl paraben and mixtures thereof.

Abstract: Compositions capable of the sustained release of active organic agents are made from an aqueous dispersion of a water-insoluble cellulose ether which cellulose ether particles have reversibly diffused therein the active agent. The dispersions may be used as dispersions, dewatered to form a powder, or coalesced to form films or other articles all of which are capable of sustained release of the active agent.

Abstract: Complete dissolution of a wide range of drugs in chlorofluorocarbon aerosol propellents is achieved by the presence of glycerol phosphatides, preferably phosphatidylcholine.

Abstract: Disclosed are antiperspirant gel stick compositions substantially free of unbound water comprising from about 5 to about 50% of a solubilized antiperspirant active, from about 7% to about 35% of intermediate polarity emollients, from about 1% to about 5% of a benzylidene sorbitol, from about 15% to about 75% of a polar solvent, from about 1% to about 20% of a coupling agent and from about 0.5% to about 10% of a bufferieng agent. These antiperspirant gel sticks provide very stable antiperspirant compositions with good efficacy as well as excellent cosmetic anesthetics which are further characterized by their ease of manufacture. Also disclosed is a method for the manufacture of these gel sticks as well as a method for treating or preventing perspiraton and malodor associated with human underarm perspiration.

Abstract: The invention includes novel pharmaceutical compositions for topical use in the therapy or prophylaxis of inflammatory skin diseases, a method of treating one or more such diseases, a novel, optically active N-substituted-isobutyramide as an active ingredient and a process for the manufacture of said novel active ingredient.

Abstract: It has been found that certain derivatives of poly(diallylmethylamine) are therapeutically effective serum cholesterol lowering agents.