Chlorine As Only Halogen Patents (Class 514/758)
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Patent number: 8940798Abstract: The present invention concerns a method for treating and/or preventing a disease in a subject comprising the step of administrating an effective amount of a compound of formula I to a subject in need thereof.Type: GrantFiled: November 5, 2012Date of Patent: January 27, 2015Assignees: Centre National de la Recherche Scientifique (CNRS), Universite Montpellier 2 Sciences et TechniquesInventor: Anne Blangy
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Patent number: 8784892Abstract: The present invention is directed to the use of an agent selected from ethyl alcohol, isopropyl alcohol or a mixture thereof and a topically acceptable polymeric carrier in the preparation of a composition for the treatment of burns.Type: GrantFiled: July 7, 2010Date of Patent: July 22, 2014Assignee: Yissum Research Development Company of the Hebrew University of JerusalemInventor: Elka Touitou
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Publication number: 20130071450Abstract: The present disclosure provides hydrogels that are suitable for drug delivery. In embodiments, hydrogels of the present disclosure may be used for transdermal delivery of bioactive agents, including drugs. The hydrogels of the present disclosure may also be useful as conductive compositions for use with electrodes.Type: ApplicationFiled: November 15, 2012Publication date: March 21, 2013Applicant: COVIDIEN LPInventor: Covidien LP
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Publication number: 20120157317Abstract: The invention provides a composition in concentrated form (“the concentrate”) for dilution with water in the preparation of an agricultural composition for application to crops, soil or animals, comprising a carbohydrate-based pH modifying agent and a pH indicator. The agricultural composition comprises an agricultural chemical whose agricultural activity varies with the pH of the water. The proportions of the pH indicator and the pH modifying agent in the concentrate are selected so that when the concentrate is diluted with an appropriate amount of water, the pH indicator indicates visually by colouration of the composition, whether or not the pH of the water is suitable for acceptable agricultural activity of the chemical. The invention also provides a process for preparing the agricultural composition by mixing the concentrate with water, and adding the agricultural chemical to the composition, if it is not already present in the concentrate.Type: ApplicationFiled: July 27, 2011Publication date: June 21, 2012Applicant: NUTRIAG LTDInventors: Kelly S.E. Tanaka, Martin David Bloomberg
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Patent number: 8044104Abstract: Provided is an aqueous liquid preparation comprising: (a) any one of a prostaglandin derivative being represented by the following formula (I), a pharmaceutically acceptable salt thereof and a hydrate thereof; and (b) at least one polyol of glycerin, propylene glycol, dipropylene glycol and 1,3-butylene glycol.Type: GrantFiled: May 28, 2008Date of Patent: October 25, 2011Assignee: Taisho Pharmaceutical Co., LtdInventors: Kaori Nishizaki, Takayuki Sato, Kentaro Goto, Kuniaki Ishii
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Publication number: 20110196383Abstract: A method and chemical composition for modifying and dissolving atherosclerotic plaques formed in a patient's blood vessels is provided. A chemical composition comprising one or more of an organic substance, an inorganic substance, and a bioactive substance is administered at sites of the plaques. The chemical composition comprises one or more of d-limonene, propylene glycol, octanoic acid, 2-octane, glycerine, acetylsalicylic acid, acetic acid, omega-3 fatty acids, ethanol, methanol, ezetimibe, rosuvastatin, resveratrol, lactic acid, gluconic acid, chloroform, carbon disulfide, dichloromethane, toluene, lauryldimethyl hydroxysultaine, and any combination thereof. The chemical composition enables modification of plaques by altering their composition. The modification comprises partial dissolution, complete dissolution, or elimination of the plaques, and makes the plaques amenable to different forms of plaque treatment. The modified plaques are eliminated from the patient's body.Type: ApplicationFiled: April 15, 2011Publication date: August 11, 2011Inventors: Kusai Saadeldin Aziz, Gary Michael Saxton
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Patent number: 7927623Abstract: Intraorally rapidly disintegrating tablets which, when ingested, disintegrates in the oral cavity rapidly without presenting unpleasant taste, can be quickly absorbed in the digestive tract and express efficacy are provided. The intraorally rapidly disintegrating tablets contain a drug being hardly water-soluble under neutral or alkaline conditions and being highly water-soluble under acidic conditions yet presenting unpleasant taste, which tablets can be prepared by combining the medicinal substance with a water-soluble acidic substance, coating either or both of the substances with a water-soluble coating agent being insoluble in alcoholic solvent, further adding a water-soluble binding agent being soluble in alcoholic solvent and a water-soluble saccharide, subjecting the resultant mixture to compression, and treating the products with an alcoholic solvent.Type: GrantFiled: February 12, 2002Date of Patent: April 19, 2011Assignee: Mitsubishi Tanabe Pharma CorporationInventors: Masaaki Sugimoto, Hideki Murakami, Yoshiyuki Koida
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Patent number: 7842730Abstract: Medicine, in particular medications for treating blood losses, hypoxic and ishemic states, for improving a blood oxygen supply and for preserving isolated perfused organs and tissues. The inventive medical emulsion of perfluororganic compounds includes rapidly excretable perfluororganic compounds such as perfluordecalin, perfluoractilbromide, a perfluoroganic additive embodied in the form of a mixture of perfluorinated tertiary amines and phospholipids in the form of a water-salt dispersion. The perfluordecalin and perfluoractilbromide are contained in the composition of the rapidly excretable perfluororganic compounds at a ratio ranging from 10:1 to 1:10. The mixture of perfluorinated tertiary amines is embodied in the form of the mixture of perfluorotpripropylamine and the co-products thereof: cis- and trans-isomers perfluor-1-propyl 3,4-dimethylpirrolidone and perfluor-1-propyl-4-methhylpiperidine.Type: GrantFiled: February 7, 2005Date of Patent: November 30, 2010Inventors: Irina Nikolaievna Kuznetsova, Evgeny Ilich Maievsky
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Publication number: 20100211010Abstract: Embodiments of the present invention provide a topical anesthetic and antiseptic dispensing device article of manufacture. In an embodiment of the invention, the article of manufacture includes a penetrating instrument including an elongated body with first and second distal end such that at least one of the distal ends includes a penetrating edge. By way of example, the penetrating instrument can be a syringe, an IV catheter needle assembly, a pressurized tube holder configured with a needle for blood draw, or a scalpel, to name a few possibilities. The article of manufacture also includes a container coupled to the elongated body of the penetrating instrument. The container provides at least one chamber. Finally, the article of manufacture includes a nozzle connected to the container and configured to dispense pressurized content of the container responsive to activating a trigger communicating with the nozzle.Type: ApplicationFiled: February 18, 2009Publication date: August 19, 2010Inventor: Michael Wycoki
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Patent number: 7709537Abstract: This invention relates to drinks and foods having osteogenetic function, each of which comprises as an active ingredient an effective amount of a culture of a propionic acid bacterium and/or a lactic acid bacterium, said culture containing 2-amino-3-carboxy-1,4-naphthoquinone; and preventives and/or remedies for metabolic bone diseases, each of which comprises as an active ingredient a naphthoquinone compound selected from the group consisting of 2-amino-3-carboxy-1,4-naphthoquinone, 1,4-naphthoquinone, 2-hydroxy-1,4-naphthoquinone, 2,3-dichloro-1,4-naphthoquinone, 5-hydroxy-1,4-naphthoquinone, 8-hydroxy-1,4-naphthoquinone, 2-(?-hydroxy-?-methylpentenyl)-5,8-dihydroxy-1,4-naphthoquinone and salts thereof. These cultures and naphthoquinones promote bone metabolism and increase bone mass and bone strength.Type: GrantFiled: October 18, 2000Date of Patent: May 4, 2010Assignee: Meiji Dairiese CorporationInventors: Kazuo Nagai, Jetae Woo, Yoshiro Sato, Kouichiro Hashimoto, Naoki Taketomo, Nobuo Yoda, Hiroshi Tsuchida
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Publication number: 20080145390Abstract: Method and article for providing a rapid, broad spectrum bacterial control, and a rapid and persistent antiviral control on an inanimate surface is disclosed. In the method, a compound or composition capable of lowering surface pH to less than about 4 is applied to the surface, and preferably is allowed to remain on the surface, and the nonvolatile components of the composition can form a barrier film or layer on a treated surface.Type: ApplicationFiled: June 4, 2007Publication date: June 19, 2008Applicant: THE DIAL CORPORATIONInventors: Timothy J. Taylor, Harry E. Towner, Janice L. Fuls, Bruce R. Cox, George E. Fischler, Priscilla S. Fox, Nancy D. Rodgers, James Dalton, Daniel E. Pedersen, John J. Rolando, Richard K. Staub
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Publication number: 20040143025Abstract: Methods and compositions are provided for treating vascular disease and modulating the inflammatory and immune processes using alkyl halides. The subject compounds are capable of inhibiting the proliferation of vascular smooth muscle cells, protecting the vasculature against oxidative stress and injury, modulating the activity of various immune system cells, inhibiting the production of pro-inflammatory cytokines and enhancing production of anti-inflammatory cytokines, thereby being effective in the treatment of conditions associated with adverse proliferative or inflammatory responses. Methods for extending the survival of an organ transplant and inhibiting chronic rejection in a recipient are also provided.Type: ApplicationFiled: September 13, 2003Publication date: July 22, 2004Inventors: Roland Buelow, Jacky Woo, Suhasini Iyer
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Publication number: 20030158156Abstract: Methods for inhibiting the production of TSST-1 from Gram positive bacteria are disclosed. The methods comprise exposing the Gram positive bacteria to compounds capable of inhibiting the production of TSST-1 from the Gram positive bacteria.Type: ApplicationFiled: October 16, 2002Publication date: August 21, 2003Applicant: Kimberly-Clark Worldwide, Inc.Inventors: Rae Ellen Syverson, Richard A. Proctor
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Publication number: 20030068387Abstract: Methods and compositions are provided for treating vascular disease and modulating the inflammatory and immune processes using carbon monoxide generating compounds, including methylene chloride. The subject compounds are capable of inhibiting the proliferation of vascular smooth muscle cells, protecting the vasculature against oxidative stress and injury, modulating the activity of various immune system cells, inhibiting the production of pro-inflammatory cytokines and enhancing production of anti-inflammatory cytokines, thereby being effective in the treatment of conditions associated with adverse proliferative or inflammatory responses. Methods for extending the survival of an organ transplant and inhibiting chronic rejection in a recipient are also provided.Type: ApplicationFiled: April 1, 2002Publication date: April 10, 2003Inventors: Roland Buelow, Jacky Woo
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Publication number: 20030053955Abstract: An insect pest eradication system comprised of a non-lethal knockout agent and an insecticide. The present invention also relates to a method of eradicating insects, particularly those found in earthen colonies, by treating the insects with a non-lethal knockout agent, such as trans-dichloroethylene, in combination with a suitable insecticide for the targeted insects.Type: ApplicationFiled: October 2, 2001Publication date: March 20, 2003Inventor: Tommy G. Taylor
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Publication number: 20030027833Abstract: A pharmaceutical composition is provided for topical administration of a local anesthetic agent. The composition comprises (a) a therapeutically effective amount of a local anesthetic agent and (b) a pharmaceutically acceptable, nonliposomal carrier comprised of a monohydric alcohol, a penetration enhancer, and polymer, which may be a hydrophilic polymer, a hydrophobic polymer or a combination thereof. The composition can be in the form of a gel, or it may form a film following application to a patient's body surface and evaporation of the monohydric alcohol. The composition provides rapid onset of local anesthesia as well as penetration of the active agent into the skin. Methods and drug delivery systems for administration of local anesthetic agents are also provided.Type: ApplicationFiled: May 7, 2002Publication date: February 6, 2003Inventors: Gary W. Cleary, Sri Mudumba, Shohreh Parandoosh, Colin J. Cleary, Raj Birudaraj, Pathamar Park
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Patent number: 6514963Abstract: The present invention comprises methods and compositions for use in inhibiting egg production by parasitic trematode worms comprising administering to an individual in need thereof an effective amount of an agent which transiently inhibits the influx of calcium through a cell membrane calcium channel. Inhibition of egg production in the worms ameliorates many of the symptoms and pathology related to infection by trematode related diseases, including Schistosomiasis. The methods can also effect disease transmission by reducing the number of eggs released into the environment available to continue the worm life cycle.Type: GrantFiled: July 18, 2001Date of Patent: February 4, 2003Assignee: The Regents of the University of CaliforniaInventors: Mark Walter, Armand Kuris
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Patent number: 6136836Abstract: A composition and method for controlling warm-blooded animal parasites comprising 1-[3-chloro-4-(1,1,2-trifluoro-2-trifluoromethoxyethoxy)phenyl]-3-(2,6,dif luorobenzoyl)urea.Type: GrantFiled: July 30, 1999Date of Patent: October 24, 2000Assignee: Isagro S.p.A.Inventors: Franco Bettarini, Paolo Piccardi
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Patent number: 6022551Abstract: A rapidly acting antimicrobial alcohol-containing composition and method of using the composition to disinfect surfaces, such as the hands is disclosed.Type: GrantFiled: January 20, 1998Date of Patent: February 8, 2000Assignee: Ethicon, Inc.Inventors: Hanuman B. Jampani, Jerry L. Newman
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Patent number: 5997893Abstract: The present invention provides antimicrobial compositions containing high levels of alcohol, carbomer polymers and antimicrobial agents. The present invention provides stable, high viscosity antimicrobial formulations possessing cosmetic characteristics.Type: GrantFiled: January 20, 1998Date of Patent: December 7, 1999Assignee: Ethicon, Inc.Inventors: Hanuman B. Jampani, Jerry L. Newman, Anthony W. Newman
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Patent number: 5955439Abstract: This invention relates to aerosol formulations of use for the administration of medicaments by inhalation and in particular to a pharmaceutical aerosol formulation which comprises (a) particulate medicament; (b) at least one sugar; and (c) a fluorocarbon or hydrogen-containing chlorofluorocarbon propellant. A method of treating respiratory disorders which comprises administration by inhalation of an effective amount of a pharmaceutical aerosol formulation as defined is also described.Type: GrantFiled: June 24, 1997Date of Patent: September 21, 1999Assignee: Glaxo Group LimitedInventor: Alexander Peter Green
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Patent number: 5550145Abstract: An antimicrobial composition comprising an antimicrobially effective amount of a combination of: A) a monoglyceride of lauric acid, a monoglyceride of monomyristic acid or a mixture of these monoglycerides, and B) at least one chemical substance selected from the following groups: i) local anesthetics of the amide type; ii) carbamide, iii) antibacterial substances in the form of steroid antibiotics, imidazole derivatives or nitroimidazole derivatives, and iv) diols with 3-6 carbon atoms, and C) optionally, a conventional physiologically acceptable carrier and/or physiologically acceptable additives. A process for the preparation of this composition by heating (A) to the transition temperature of the lipid, adding (B), and optionally (C), and cooling the mixture to form a solid lipid crystal composition. Use of the composition for the preparation of a dermatological preparation for combatting bacteria and fungi or as a preservative additive in a cosmetic product, a food product, or a medical product.Type: GrantFiled: September 27, 1994Date of Patent: August 27, 1996Assignee: Bioglan ABInventors: Karin Olund, Lena-Karin L utz, Rickard Bryland, .ANG.ke Lindahl
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Patent number: 5198432Abstract: Ionizable congeners of aromatic and aliphatic alcohols provide potent cytoprotective properties in vivo and in vitro. Alpha-tocopherol succinate, cholesteryl succinate, cholesteryl sulfate, dihydrocholesterol succinate, dihydrocholesterol sulfate, and ergosterol analogs are particularly good cytoprotective agents. In addition, the tris salts of these compounds have superior cytoprotective properties.Type: GrantFiled: April 1, 1991Date of Patent: March 30, 1993Assignees: Center for Innovative Technology, Virginia Commonwealth UniversityInventor: Marc W. Fariss
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Patent number: 5010110Abstract: A water activated solid, emollient preparation is disclosed, said preparation having a homogenous crystal/gel matrix which is capable of incorporating up to 30% by weight of emollient and holding it in a solid form. When the preparation is rubbed on wet skin, it deposits an elegant occlusive emollient film. A method of pouring and cooling said product into bars is also disclosed.Type: GrantFiled: April 27, 1990Date of Patent: April 23, 1991Assignee: Avon Products, Inc.Inventors: James M. Wilmott, William H. Koelle, Alexander P. Znaiden
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Patent number: 4895876Abstract: A stable concentrated aqueous emulsion of perfluorochemical, a phospholipid and a triglyceride of fatty acids has been demonstrated which has enhanced stability, diminished particle size and heightened tolerance by biological systems. The emulsion has utility as an oxygen transport medium, such as artificial blood. The emulsion can optionally include additional emulsifiers of SURFYNOL.RTM.SE surfactant and PLURONIC.RTM. P-105 surfactant. The emulsion is produced using an improved emulsification technique. The invention includes methods of oxygen transport in vascular systems wherein the oxygen carrying capacity of the vascular systems is improved with the emulsions of the present invention. Methods are also described for organ preservation extra-vivo by perfusing, suffusing, flushing and filling organs outside the body with the oxygen carrying emulsions of the present invention.Type: GrantFiled: March 20, 1987Date of Patent: January 23, 1990Assignee: Air Products and Chemicals, Inc.Inventors: Frank K. Schweighardt, Charles R. Kayhart
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Patent number: 4764361Abstract: The invention includes novel pharmaceutical compositions for topical use in the therapy or prophylaxis of inflammatory skin diseases, a method of treating one or more such diseases, a novel, optically active N-substituted-isobutyramide as an active ingredient and a process for the manufacture of said novel active ingredient.Type: GrantFiled: March 11, 1987Date of Patent: August 16, 1988Assignee: Imperial Chemical Industries PLCInventors: Andrew J. T. Bilski, Ralph Howe, Balbir Rao, David S. Thomson
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Patent number: 4720508Abstract: The invention relates to acaricidal compositions for the control of ectoparasites of domesticated, warm blooded animals. Methods for application of the composition disclosed are also taught.Type: GrantFiled: December 11, 1986Date of Patent: January 19, 1988Assignee: International Minerals & Chemical Corp.Inventors: Jing-Jong Lu, Radmilo A. Todorovic
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Patent number: 4668513Abstract: A method for overcoming snoring is disclosed. A composition is used containing a surface active substance, a preserving agent and/or a substance acting bactericidally or fungicidally on the mucous membranes and optionally a substance for softening the mucous membranes in physiological common salt solution as well as optionally further additives which are compatible with the mucous membranes.Type: GrantFiled: August 5, 1985Date of Patent: May 26, 1987Inventor: Dietrich Reichert
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Patent number: 4657936Abstract: The invention relates to acaricidal compositions for the control of ectoparasites of domesticated, warm blooded animals. Methods for application of the composition disclosed are also taught.Type: GrantFiled: October 18, 1985Date of Patent: April 14, 1987Assignee: International Minerals & Chemical Corp.Inventors: Jing-Jong Lu, Radmilo A. Todorovic
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Patent number: 4556557Abstract: A composition for overcoming snoring as well as a process for its use is disclosed. The composition according to the invention contains a surface active substance, a preserving agent and/or a substance acting bactericidally or fungicidally on the mucous membranes and optionally a substance for softening the mucous membranes in physiological common salt solution as well as optionally further additives which are compatible with the mucous membranes.Type: GrantFiled: July 15, 1983Date of Patent: December 3, 1985Inventor: Dietrich Reichert
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Patent number: 4511556Abstract: A method of inactivating a lipid virus in a protein carrier selected from the group consisting of Hepatitis B virus (HBV) and non-A, non-B hepatitis (NANBH) by contacting said virus for an extended period of time and ambient temperature with a halohydrocarbon treating agent preferably chloroform in an amount of 5% v/v to 50% v/v.Type: GrantFiled: June 10, 1982Date of Patent: April 16, 1985Assignee: The United States of America as represented by the Department of Health and Human ServicesInventors: Robert H. Purcell, Stephen M. Feinstone
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Patent number: RE44704Abstract: The present invention is based on the discovery that the administration of at least one immunoconjugate and at least one chemotherapeutic agent provides an unexpectedly superior treatment for cancer. The present invention is directed to compositions comprising at least one immunoconjugate and at least one chemotherapeutic agent and to methods of treating cancer using at least one immunoconjugate and at least one chemotherapeutic agent. The present invention also provides methods of modulating the growth of selected cell populations, such as cancer cells, by administering a therapeutically effective amount of at least one chemotherapeutic agent and at least one immunoconjugate.Type: GrantFiled: September 13, 2012Date of Patent: January 14, 2014Assignee: Immunogen Inc.Inventors: Ravi V. J. Chari, Walter A. Blättler