Solid Synthetic Organic Polymer Patents (Class 514/772.3)
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Patent number: 8877293Abstract: A process for preparing emulsions of silicone gums is disclosed based on using an ethylene oxide/propylene oxide block copolymer as the emulsifier. The emulsions produced by the present process are useful as coatings additives for both water-based and oil-based coatings to obtain improved slip and anti-mar properties. The emulsions may also be used in the manufacture of tires as band ply lubricants. They may also be used in personal care applications.Type: GrantFiled: August 2, 2011Date of Patent: November 4, 2014Assignee: Dow Corning CorporationInventors: Steven Mark Evans, Donald Taylor Liles, Mustafa A. Mohamed
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Patent number: 8877225Abstract: The present invention provides a constant release copolymer composition adapted for use in a controlled release formulation for a bioactive agent, such as a formulation adapted for implantation within a patient's body tissues as a depot to release the agent over a period of time, wherein the copolymer provides a substantially constant rate of release of the bioactive agent over the time period for which the depot persists in the body tissues. The copolymer includes a PLG copolymer and a PLG oligomer of about 5-10 kDa average molecular weight, which can lack free carboxylic acid groups. When the PLG copolymer is a low burst copolymer, the constant release copolymer composition is a low burst, constant release copolymer composition adapted for implantation in the body tissues of a mammal, wherein a substantially constant rate of release of the bioactive agent is achieved.Type: GrantFiled: June 3, 2009Date of Patent: November 4, 2014Assignee: Tolmar Therapeutics, Inc.Inventors: Richard L. Norton, Eric Dadey
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Publication number: 20140322309Abstract: ?-Aminoamidine polymers and methods of preparing a-aminoamidine polymers by reacting by reacting one or more amines with one or more isocyanides and one or more aldehydes are described. Methods of preparing a-aminoamidine polymers from commercially available starting materials are also provided, wherein the starting materials are racemic or stereochemically pure. a-Aminoamidine polymers or salt forms thereof are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems and for other purposes as well such as, for example, coatings, additives, excipients, plastics, and materials, etc. Given the amino moiety of these ?-aminoamidine polymers, they are particularly suited for the delivery of polynucleotides. Complexes, micelles, liposomes or particles containing the inventive ?-aminoamidine polymers and polynucleotides can be prepared. The inventive ?-aminoamidine polymers may also be used in preparing microparticles for drug delivery.Type: ApplicationFiled: December 15, 2012Publication date: October 30, 2014Applicant: Massachusetts Institute of TechnoloInventors: Arturo Jose Vegas, Kathryn Ann Whitehead, Daniel Griffith Anderson, Robert S. Langer, Joseph R. Dorkin
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Gastrointestinal absorption enhancer mediated by proton-coupled transporter and its preparing method
Patent number: 8871818Abstract: The present invention provides a pharmaceutical preparation that can improve absorption of a pharmaceutical compound in the gastrointestinal tract and that provides, through oral administration or like method, a blood concentration from which sufficient remedial effects can be expected, and a method for producing such a preparation. The invention is directed to a pharmaceutical preparation exhibiting excellent gastrointestinal absorbability comprising a compound recognized by a proton-coupled transporter and a pH-sensitive polymer in an amount sufficient for the gastrointestinal tract to acquire a pH at which the proton-coupled transporter optimally absorbs the compound into a cell.Type: GrantFiled: October 21, 2008Date of Patent: October 28, 2014Assignees: Otsuka Pharmaceutical Co., Ltd.Inventors: Akira Tsuji, Ikumi Tamai, Yoshimichi Sai, Masaaki Odomi, Hidekazu Toyobuku -
Publication number: 20140316012Abstract: The present invention provides systems and methods for occluding and/or embolizing a cavity within a patient by delivering a prepolymer material into or onto a cavity and forming an expanding foam within the cavity. The inventions methods are applicable to occluding a variety of cavities, including blood vessels, aneurysms, left arterial appendages, vascular malformations and the like.Type: ApplicationFiled: March 12, 2014Publication date: October 23, 2014Inventors: Toby Freyman, Jennifer Mortensen
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Patent number: 8865200Abstract: Disclosed are sustained release compositions for vaginal or transdermal administration that contain a progesterone receptor modulator such as CDB-2914 (also referred to as VA-2914), and methods of using them for long term contraception or therapeutic purposes. Also disclosed are methods for making the compositions.Type: GrantFiled: July 8, 2005Date of Patent: October 21, 2014Assignee: Laboratoire HRA PharmaInventors: Regine Sitruk-Ware, Yun-Yen Tsong
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Patent number: 8853247Abstract: The invention provides (among other things) small molecule drugs that are chemically modified by covalent attachment of a water soluble oligomer.Type: GrantFiled: October 31, 2008Date of Patent: October 7, 2014Assignee: Nektar TherapeuticsInventors: Zhongxu Ren, Jennifer Riggs-Sauthier, Michael D. Bentley
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Patent number: 8852648Abstract: A composition and method adapted for delivery of hydrophilic, biologically-active agents are disclosed. The composition can include a reverse microemulsion formed from at least one hydrophilic, biologically-active agent solubilized by a hydrophobic reverse emulsion surfactant in a non-stinging, volatile, hydrophobic solvent. The non-stinging, volatile, hydrophobic solvent is selected from the group consisting of volatile linear and cyclic siloxanes, volatile linear, branched, and cyclic alkanes, volatile fluorocarbons and chlorofluorocarbons, liquid carbon dioxide under pressure, and combinations thereof. The reverse microemulsion can be an optically clear solution.Type: GrantFiled: October 21, 2013Date of Patent: October 7, 2014Assignee: Rochal Industries, LLPInventors: Joseph Charles Salamone, Xiaoyu Chen, Ann Beal Salamone, Katelyn Elizabeth Reilly
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Publication number: 20140296282Abstract: Delivery systems and compositions comprised of a biodegradable polyorthoester polymer, an aprotic solvent, and a drug are described. The solvent is selected to modulate release of drug from the composition, where, in some embodiments, the solvent is rapidly released after administration and provides a corresponding rapid rate of drug release. Alternatively, in other embodiments, the solvent is slowly released from the composition after its administration, and provides a correspondingly slow rate of drug release.Type: ApplicationFiled: March 14, 2014Publication date: October 2, 2014Applicant: Heron Therapeutics, Inc.Inventors: Thomas B. Ottoboni, Lee Ann Lynn Schillinger, Joseph Niemann
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Patent number: 8846770Abstract: Disclosed herein are compositions and methods for the treatment of otic diseases or conditions with aural pressure modulating agent compositions and formulations administered locally to an individual afflicted with an otic disease or condition, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s).Type: GrantFiled: June 17, 2009Date of Patent: September 30, 2014Assignees: Otonomy, Inc., The Regents of the University of CaliforniaInventors: Jay Lichter, Benedikt Vollrath, Sergio G. Durón, Michael Christopher Scaife, Fabrice Piu, Qiang Ye, Luis A. Dellamary, Carl Lebel, Andrew M. Trammel, Jeffrey P. Harris
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Patent number: 8846070Abstract: A medical article is disclosed, comprising a biologically degradable AB block copolymer and a biologically degradable polymer that is capable, at equilibrium and at room temperature, of absorbing less than about 5 mass % water.Type: GrantFiled: July 29, 2008Date of Patent: September 30, 2014Assignee: Advanced Cardiovascular Systems, Inc.Inventors: Yiwen Tang, Syed F. A. Hossainy, Andrew C. Tung, Stephen D. Pacetti
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Publication number: 20140288190Abstract: Hydrogels that degrade under appropriate conditions of pH and temperature by virtue of crosslinking compounds that cleave through an elimination reaction are described. The hydrogels may be used for delivery of various agents, such as pharmaceuticals. This invention provides hydrogels that degrade to smaller, soluble components in a non-enzymatic process upon exposure to physiological conditions and to methods to prepare them. The hydrogels are prepared from crosslinking agents that undergo elimination reactions under physiological conditions, thus cleaving the crosslinking agent from the backbone of the hydrogel. The invention also relates to the crosslinking agents themselves and intermediates in forming the hydro gels of the invention. The biodegradable hydro gels prepared according to the methods of the invention may be of use in diverse fields, including biomedical engineering, absorbent materials, and as carriers for drug delivery.Type: ApplicationFiled: September 7, 2012Publication date: September 25, 2014Applicant: ProLynx LLCInventors: Gary W. Ashley, Daniel V. Santi, Jeffrey C. Henise
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Publication number: 20140287014Abstract: This invention includes malleable, biodegradable, fibrous compositions for application to a tissue site in order to promote or facilitate new tissue growth. One aspect of this invention is a fibrous component that provides unique mechanical and physical properties. The invention may be created by providing a vessel containing a slurry, said slurry comprising a plurality of natural or synthetic polymer fibers and at least one suspension fluid, wherein the polymer fibers are substantially evenly dispersed and randomly oriented throughout the volume of the suspension fluid; applying a force, e.g., centrifugal, to said vessel containing said slurry, whereupon said force serves to cause said polymer fibers to migrate through the suspension fluid and amass at a furthest extent of the vessel, forming a polymer material, with said polymer material comprising polymer fibers of sufficient length and sufficiently viscous, interlaced, or interlocked to retard dissociation of said polymer fibers.Type: ApplicationFiled: January 20, 2014Publication date: September 25, 2014Inventors: Timothy A. Ringeisen, William Christopher Wattengel
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Publication number: 20140271521Abstract: A process for forming a personal care article, the process including (a) producing an extrudate from a twin screw extruder, and (b) forming the extrudate into the personal care article. The personal care article includes (i) from about 10% to about 60% of one or more anionic surfactants, wherein the one or more anionic surfactants have a Krafft point of less than 30° C.; (ii) from about 10% to about 50% of one or more water soluble polymers; (iii) from about 1% to about 30% of one or more plasticizers; and (iv) from about 10% to about 50% water.Type: ApplicationFiled: March 14, 2014Publication date: September 18, 2014Applicant: The Procter & Gamble CompanyInventors: Robert Wayne GLENN, JR., Todd Ryan THOMPSON, Ungyeong JUNG, Changwei ZHU, Alireza TABATABAEI-NAEINI
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Publication number: 20140271745Abstract: Provided is a personal care article including one or more extruded dissolvable fibers. The extruded dissolvable fibers include (a) from about 10% to about 60% of one or more anionic surfactants; (b) from about 10% to about 50% of one or more water soluble polymers; (c) from about 1% to about 30% of one or more plasticizers; and (d) from about 0.01% to about 30% water. The one or more anionic surfactants have a Krafft point of less than about 30° C. The one or more extruded dissolvable fibers has an average diameter of from about 20 microns to about 1,000 microns. The personal care article has a dry density of from about 0.02 g/cm3 to about 0.30 g/cm3.Type: ApplicationFiled: March 14, 2014Publication date: September 18, 2014Applicant: The Procter & Gamble CompanyInventors: Robert Wayne GLENN, JR., Todd Ryan THOMPSON, Ungyeong JUNG, Chul B. PARK, Changwei ZHU, Raymond Kar Man CHU
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Publication number: 20140271601Abstract: Methods of controlled delivery of bioactive therapeutics are provided. Compositions comprising therapeutic implants are provided.Type: ApplicationFiled: March 13, 2014Publication date: September 18, 2014Applicant: InVivo Therapeutics CorporationInventors: Alex A. Aimetti, Timothy M. O'Shea, Robert S. Langer, Xueqing Zhang
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Publication number: 20140255311Abstract: Disclosed are compositions and synthesis methods that pertain to biocompatible polymeric capsules capable of undergoing backbone degradation and cargo release upon exposure to biologically relevant concentrations of hydrogen peroxide (50-100 ?M of H2O2). In the invention, bio-responsive polyester bearing boronic ester triggers groups that degrade upon exposure to low concentrations of H2O2. The degradation is induced by transformation of a boronic ester to a phenol, which undergoes a quinone methide rearrangement to break down the polyester backbone.Type: ApplicationFiled: March 6, 2014Publication date: September 11, 2014Applicant: The Regents of the University of CaliforniaInventors: Adah Almutairi, Carolina De Gracia Lux
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Publication number: 20140255322Abstract: A siloxane polymer base that is useful as an excipient for many variable materials that can be compounded into it. Also disclosed are a method for the preparation of such bases, and another method regarding the preparation of the base and actives.Type: ApplicationFiled: May 23, 2014Publication date: September 11, 2014Inventors: John D. Blizzard, Robert L. McKellar
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Patent number: 8828980Abstract: Disclosed herein are compositions and methods for the treatment of otic disorders with steroid, NSAID, and/or adenosine triphosphatase (“ATPase”) modulator agents. In these methods, the steroidal, NSAID, and/or ATPase compositions and formulations are administered locally to an individual afflicted with an otic disorder, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s).Type: GrantFiled: July 25, 2011Date of Patent: September 9, 2014Assignees: Otonomy, Inc., The Regents of the University of CaliforniaInventors: Jay Lichter, Fabrice Piu, Qiang Ye, Luis A. Dellamary, Carl Lebel, Andrew M. Trammel, Jeffrey P. Harris
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Publication number: 20140249202Abstract: Described herein are carrier nanoparticles comprising a polymer containing a polyol coupled to a polymer containing a boronic acid, configured to present the polymer containing a boronic acid to an environment external to the nanoparticle. Targeted versions of the described nanoparticles are also described, as are related compositions, methods and systems.Type: ApplicationFiled: March 1, 2013Publication date: September 4, 2014Inventors: Mark E. Davis, Han Han
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Patent number: 8822550Abstract: The present invention provides a UCST-type thermoresponsive polymer compound which responds to a temperature under physiological conditions and has biofunctionality, and various uses thereof as a thermoresponsive material. Specifically, the invention provides a thermoresponsive material containing, as an active ingredient, a polymer compound represented by Formula (I) below or an addition salt thereof, the thermoresponsive material having an upper critical solution temperature in the range of 5 to 50° C. in an aqueous solution with a salt concentration of at least 1 mM and a pH in the range of 3 to 10.5: wherein m represents an integer of 10 or more; n represents a number satisfying 0.4?n?1; R1 represents hydrogen or succinyl; and R2 represents carbamoyl.Type: GrantFiled: March 22, 2011Date of Patent: September 2, 2014Assignee: Kyushu University, National University CorporationInventors: Naohiko Shimada, Atsushi Maruyama
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Publication number: 20140243395Abstract: A spray system for production of a matrix formed in situ is described, which comprises at least one lipophilic component comprising at least one polymer based on glycolic acid and lactic acid and at least one biocompatible solvent having an X log P3 value of less than 0.2, and at least one hydrophilic component, wherein the at least two components are present separately from each other prior to use and are not mixed until or in the course of spraying, with components forming a film when sprayed onto human tissue.Type: ApplicationFiled: September 25, 2012Publication date: August 28, 2014Applicant: ETHRIS GMBHInventors: Carsten Rudolph, Senta Üzgün
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Publication number: 20140243427Abstract: The invention relates to processes for preparing a synthetic foam having present therein particles with a controlled particle distribution and the use of said foam, as well as to foams as such. Accordingly the invention is directed to a process for preparing a synthetic foam having present therein particles, wherein the distribution of said particles is controlled by the following steps of dissolving at least one synthetic polymer in one or more solvents to form a solution; contacting particles with said solution to form a polymer/particles mixture; and freeze-drying the polymer/particles mixture by: freezing the polymer/particles mixture; and subsequently subliming the one or more solvents to form a synthetic foam comprising said particles.Type: ApplicationFiled: October 1, 2012Publication date: August 28, 2014Inventors: Bhushan Chandrashekhar-Bhat, Martin Franke Tooren, Robbert Arnold de Graaf, Romke Stephan Rudolf Ribbels
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Publication number: 20140243426Abstract: A composition for cryopreservation of cells and tissues of human and other animals in a safe manner without using toxic substances such as DMSO, as well as for freeze preserving or freeze-drying of foods and pharmaceuticals. In embodiments, ?-poly-L-lysine is reacted with succinic anhydride so that 60% or more of amino groups are blocked; and, thus obtained polymer compound is added to Dulbecco-modified eagle MEM culture medium (DMEM) on market sale to form a cryopreservation liquid. In embodiments for foods or pharmaceuticals, the ?-poly-L-lysine derivative was added by 0.5-10 wt % to curb freeze concentration.Type: ApplicationFiled: April 30, 2014Publication date: August 28, 2014Applicant: Bio Verde Inc.Inventors: Kazuaki MATSUMURA, Hajime SUGAI, Suong-Hyu HYON
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Patent number: 8815801Abstract: A controlled release composition containing a physiologically active substance in high content, suppressing the initial excess release, and achieving a stable release speed over a long period of time is provided. A controlled release composition comprising (1) a physiologically active substance or salt thereof in an amount of about 14% (w/w) to about 24% (w/w) based on the total composition weight, (2) hydroxynaphthoic acid selected from the group consisting of 3-hydroxy-2-naphthoic acid and 1-hydroxy-2-naphthoic acid or salt thereof, and (3) a lactic acid polymer or salt thereof having a weight-average molecular weight of 15000 to 50000 in which the content of polymers having molecular weights of 5000 or less is about 5% by weight or less, wherein the molar ratio of said hydroxynaphthoic acid or salt thereof to said physiologically active substance or salt thereof is from 3:4 to 4:3.Type: GrantFiled: July 13, 2012Date of Patent: August 26, 2014Assignee: Takeda Pharmaceutical Company LimitedInventors: Kazumichi Yamamoto, Akiko Yamada, Yoshio Hata
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Publication number: 20140234233Abstract: Described are associative thickeners based on compounds which comprise at least one hydrophobically modified polyether dendron end group.Type: ApplicationFiled: April 28, 2014Publication date: August 21, 2014Applicant: BASF SEInventors: Holger Türk, Volker Wendel, Anna Cristadoro, Rabie Al-Hellani, Bernd Bruchmann
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Patent number: 8802088Abstract: The present invention relates to a composition which comprises tryptophan whereby 10 to 90%, preferably 20 to 80% of the tryptophan is present as free tryptophan or peptide-bound tryptophan and 10 to 90%, preferably 20 to 80% of the tryptophan is present as polypeptide-bound tryptophan.Type: GrantFiled: April 27, 2009Date of Patent: August 12, 2014Assignee: DSM IP Assets B.V.Inventors: Cinderalla C. Gerhardt, Luppo Edens
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Patent number: 8802125Abstract: The invention concerns a system for biocompatible drug release comprising: (i) a polymer matrix; (ii) an inorganic component located inside said matrix and characterized by a lamellar structure with a net positive or negative charge able to intercalate (iii) a pharmacologically active principle into said lamellar structure, by establishing an ionic type of bond with it and thereby obtaining an intercalation compound. The preparation process for the release system comprises the stages of: treating the lamellar solid in such a way as to give it a net positive or negative charge, then combining it with the chosen active principle, also in an ionic form, to obtain an intercalation compound which is then mixed with the polymer matrix. The release system can be employed in making medical devices, like sutures, membranes, osteosynthesis plaques, multilayered devices, gels and drug delivery systems.Type: GrantFiled: July 21, 2006Date of Patent: August 12, 2014Assignee: ARIANNA Medical DevicesInventors: Gaetano Marenzi, Adele Bolognese, Luigi Califano, Antonio Calignano, Umberto Costantino, Gilberto Sammartino, Vittoria Vittoria
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Patent number: 8802738Abstract: The invention relates to polymers, such as aliphatic polyesters, with grafted zwitterions. More particularly, the invention relates to polyester-graft-phosphorylcholine polymers prepared by ring-opening polymerization and click chemistry, compositions and products comprising same, and related methods and uses, for example, in drug delivery.Type: GrantFiled: December 11, 2009Date of Patent: August 12, 2014Assignee: University of MassachusettsInventor: Todd Emrick
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Publication number: 20140221922Abstract: Bioactive hydroforming luminal liner compositions are formed of an absorbable crystalline amphiphilic polyether-ester-urethane dissolved in a liquid derivative of a polyether glycol that undergoes transformation into a tissue-adhering, resilient interior cover or liner for the controlled release of its bioactive payload at clinically compromised conduits in humans as in the case of bacteria- and yeast-infected vaginal canals, esophagi, and arteries following angioplasty.Type: ApplicationFiled: April 7, 2014Publication date: August 7, 2014Applicant: POLY-MED, INC.Inventors: Shalaby W. Shalaby, David Ingram, Georgios Hilas, Sheila Nagatomi
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Publication number: 20140212363Abstract: Polyamide compositions useful for personal care are disclosed, including film-forming concentrates and emulsions. Ethanol-based concentrates comprise a hydrophobic polyamide, which comprises a reaction product of either (a) a dimerized fatty acid, at least one C2-C4 carboxylic acid, and a polyamine component comprising ethylenediamine and 1 to 30 eq. % of one or more di- or triamines; or (b) a dimerized fatty acid, at least 50 wt. % of a C16-C22 unsaturated carboxylic acid, and at least one C2-C6 diamine. Personal care applications for the concentrates, including continuous sunscreens, fragrant body sprays or splashes, anti-acne medications, are included. Water-in-oil emulsions comprising the hydrophobic polyamides are storage-stable and provide water-resistant SPF for products such as sunscreens and body lotions.Type: ApplicationFiled: September 7, 2012Publication date: July 31, 2014Applicant: CRODA INTERNATIONAL PLCInventors: Nancy W. Harman, George Miller, Thomas Fontana, Neal Kerckhoff, Jason Rothouse, Ramachandra Shastry
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Patent number: 8790622Abstract: The present invention concerns formulations containing one or more comb structure amphiphilic copolymers that are both rich in hydrophobic monomers and in polyalkylene glycol monomers. Cosmetic formulations. Methods of thickening.Type: GrantFiled: March 7, 2012Date of Patent: July 29, 2014Assignee: CoatexInventors: Renaud Souzy, Jean-Marc Suau, Yves Kensicher, Olivier Guerret
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Patent number: 8785389Abstract: This invention relates to the production of biomaterials from polymeric collagen (PC) and its seeding with cells and other components of biomaterials. Polymeric collagen is isolated from tissue, suspended in an acidic solution, and then neutralized at low temperature. The neutralized suspension is then seeded with biomaterial components, such as cells, and the polymeric collagen aggregated to form a biomaterial comprising the biomaterial components. Polymeric collagen biomaterials produced as described herein may therefore be useful in a range of tissue engineering applications.Type: GrantFiled: July 16, 2010Date of Patent: July 22, 2014Assignee: UCL Business PLCInventors: Robert Brown, Burcak Alp, Hector Hadjipanayi
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Publication number: 20140194533Abstract: The present invention provides a biocompatible and biodegradable elastomer, comprising a hard segment and a soft segment. The hard segment is formed by reacting diisocyanate and a chain extender; and the soft segment is comprising a biodegradable oligomer diol, wherein the biodegradable oligomer diol is selected from the group consisting of polycaprolactone diol, polyethylene butylene adipate diol (PEBA diol), poly-L-lactic acid diol (PLLA diol), polylactic acid diol and any combination thereof. The biocompatible and biodegradable elastomer of present invention can be used to produce vascular graft, cell carrier, drug carrier or gene carrier.Type: ApplicationFiled: December 31, 2013Publication date: July 10, 2014Applicant: National Taiwan UniversityInventors: Shan-hui Hsu, Kun-Che Hung, Shenghong A. Dai, Chun-Yi Lu
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Publication number: 20140193350Abstract: The application relates to cosmetic agents, cleaning agents, and fabric treatment agents containing a combination of at least two different microcapsules as well as to methods for releasing active substances from said microcapsules when using said agents.Type: ApplicationFiled: March 10, 2014Publication date: July 10, 2014Applicant: Henkel AG & Co. KGaAInventors: Andreas Bauer, Ursula Huchel, Stefan Urlichs, Manuela Materne, Klaus Last, Daniel Mues
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Patent number: 8771739Abstract: The present invention provides a pharmaceutical composition of a practically insoluble drug, wherein the composition may be administered with food or without food. The composition may be in the form of a solid dispersion of the practically insoluble drug and a polymer having acidic functional groups, and the composition may in vitro form a suspension.Type: GrantFiled: June 15, 2007Date of Patent: July 8, 2014Assignee: Mayne Pharma International Pty LtdInventors: David Hayes, Angelo M. Morella
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Patent number: 8772355Abstract: The present invention is directed to a crosslinked or non-crosslinked polymer particle, wherein the crosslinked polymer particle comprises a copolymer of poly(alklyene glycol-graft-acrylate) that is crosslinked by at least one hydrolysable monomer or crosslinking agent. The present invention is also directed to a polymer particle comprising a crosslinked polymer particle that is a product of starting materials comprising (a) a hydrophilic monomer, (b) a hydrophobic monomer, and (c) a hydrolysable crosslinking agent (the crosslinking agent may be absent in the case of non-crosslinked particles). The present invention is still further directed to a polymer particle comprising a crosslinked copolymer, where the crosslinked copolymer includes structures represented by Formulas (I), (II), and (III), as defined in the specification. Other embodiments of the present invention also include methods of manufacturing polymer particles.Type: GrantFiled: November 23, 2010Date of Patent: July 8, 2014Assignee: Howard UniversityInventors: Emmanuel Akala, Oluyomi Okunola
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Publication number: 20140186441Abstract: A biocompatible, resorbable composite for osteosynthesis includes osteoconductive particles dispersed within a porous polymer matrix having a plurality of fluid passageways that expose at least a portion of a plurality of the osteoconductive particles to an exterior of the polymer matrix. The composite may further include a chemical additive incorporated within the polymer matrix, the chemical additive being configured to modify one or more of acidity, degradation rate, melting point, hydrophilicity, and hydrophobicity of the polymer matrix. A method for making the composite includes mixing the osteoconductive particles with polymer material and the chemical additive to form a mixture and treating the mixture to bind the osteoconductive particles with the polymer material to create a solid unit.Type: ApplicationFiled: March 13, 2013Publication date: July 3, 2014Applicant: DePuy Synthes Products, LLCInventors: Stefan Beck, Lorenz Niederberger, Nico Stohler
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Publication number: 20140186417Abstract: An aliphatic polyester polymer for stent coating is described.Type: ApplicationFiled: February 20, 2014Publication date: July 3, 2014Applicant: Abbott Cardiovascular Systems Inc.Inventors: O. Mikael Trollsas, Lothar W. Kleiner, Syed F.A. Hossainy
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Publication number: 20140186278Abstract: An anhydrous multiphase gel system consisting of an outer lipid matrix and an inner phase gelled by means of a polymer is described, which can be obtained by a) Melting the lipid phase with the formation of a liquid lipid phase, b) Mixing and homogenizing polymers or polymer blends capable of swelling with the formation of a polymer phase to be dispersed, c) Combining the polymer phase with the liquid lipid phase and homogenizing the phases, and d) Cold stirring the phase mixture until a solid gel-like mixed structure of the entire system is formed. The anhydrous multiphase gel system is particularly suitable for taking up difficulty soluble active substances in high concentration and for providing topical and transdermal applications. The described system is called an EDRS, “Entrapped Drug Reservoir System”.Type: ApplicationFiled: September 19, 2013Publication date: July 3, 2014Inventor: Patrick Franke
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Patent number: 8765822Abstract: A composition in the form of a positive latex includes: a) 50-80 wt. % of at least one cross-linked, branched, or linear organic polymer (P), b) 5-10 wt. % of a water-in-oil (W/O) emulsifying system (S1), c) 5-45 wt. % of at least one oil, and d) 0-5 wt. % of water. Between 0.01 mol. % and 10 mol. % of the monomeric patterns of the monomer P include at least one neutral monomer of formula (I): C(R1)(R3)?C(R2)—C(?O)—O—(CH2—CH2—O)n—R4 (I) wherein the radicals R1, R2 and R3, which are the same or different, independently represent a hydrogen atom or a linear or branched alkyl radical including between 1 and 4 carbon atoms, the radical R4 represents a linear or branched, saturated or unsaturated, aliphatic radical including between 6 and 30 carbon atoms, and n represents a number between 1 and 50. A production method and use are also described.Type: GrantFiled: February 24, 2012Date of Patent: July 1, 2014Assignee: Societe d'Exploitation de Produits pour les Industries Chimiques SEPPICInventors: Olivier Braun, Paul Mallo
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Patent number: 8759255Abstract: The invention relates to compositions containing a) one or more pesticides, b) one or more copolymers obtained by the copolymerization of i) glycerol, ii) at least one dicarboxylic acid, and iii) at least one monocarboxylic acid, c) one or more amphoteric surface-active substances, and d) water. The compositions are particularly suitable for controlling and/or combating weeds, fungal diseases, or insect infestation.Type: GrantFiled: September 4, 2010Date of Patent: June 24, 2014Assignee: Clariant Finance (BVI) LimitedInventor: Andreas Wacker
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Publication number: 20140170229Abstract: Biodegradable polymeric nanoparticles comprising an inner core formed of a photodynamic agent capable of being activated to generate cytotoxic singlet oxygen are prepared. These nanoparticles have anti-cell proliferation activity and are useful in treating both cancerous and non-cancerous conditions including actinic keratosis, psoriasis and acne vulgaris. Preferably, the photodynamic agent is a hypocrellin B derivative while the polymeric nanoparticle comprises polyglycolic acid, polylactic acid or poly(lactide-co-glycolide). Hypocrellin-comprising nanoparticles are demonstrated to be activated by light or hydrogen peroxide.Type: ApplicationFiled: August 11, 2011Publication date: June 19, 2014Applicant: Quest Pharmatech Inc.Inventors: Azita Haddadi, Ragupathy Madiyalakan, Thomas Woo
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Patent number: 8753657Abstract: The present invention relates to an antibacterial resin composition derived from a master batch, an antibacterial fiber, an antibacterial film, and a producing method of an antibacterial resin composition therefrom, comprising a polyethylene terephthalate resin as the component (A), and a polybutylene terephthalate resin as the component (B), an antibacterial glass which elutes silver ions as a component (C), which is characterized by having a composition formulated below (A) a polyethylene terephthalate resin: 100 pbw (B) a polybutylene terephthalate resin: 0.5 to 25 pbw (C) an antibacterial glass: 0.1 to 10 pbw.Type: GrantFiled: October 20, 2011Date of Patent: June 17, 2014Assignee: Koa Glass Co., Ltd.Inventor: Yoshinao Kobayashi
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Patent number: 8754135Abstract: The present invention relates to compound of formula I, which are functionalized, non-phenolic amino acids, and polymers formed from the same. Polymers formed from the functionalized amino acids are expected to have controllable degradation profiles, enabling them to release an active component over a desired time range. The polymers are also expected to be useful in a variety of medical applications.Type: GrantFiled: August 7, 2013Date of Patent: June 17, 2014Assignee: Bezwada Biomedical, LLCInventor: Rao S Bezwada
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Patent number: 8753658Abstract: A termite bait includes a plurality of cellulosic food material pieces palatable to termites embedded within a water resistant polyurethane foam matrix. Another termite bait includes a plurality of cellulosic food material pieces embedded within a water-absorbent polyurethane foam matrix. Yet another termite bait includes at least one cellulosic food material piece encapsulated within a water resistant polyurethane foam coating. Such termite baits can be used alone or in a monitoring device or other termite control device. Another termite control device includes a container, a cellulosic food material within the container and a water resistant polyurethane foam positioned to separate the food material from its environment. The container can contain a termite bait as described above or can include a chamber containing a cellulosic food material and at least one pocket containing a polyurethane foam barrier to reduce intrusion of water through the pocket to the food material.Type: GrantFiled: March 15, 2013Date of Patent: June 17, 2014Assignee: Dow AgroSciences, LLC.Inventors: Joseph Edward Eger, Jr., Donald E. Williams, III, Sol M. Mirasol, Mike P. Tolley, Joseph J. DeMark, Matthew T. Messenger, Phillip J. Howard
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Publication number: 20140155495Abstract: A composition suitable for use in a transdermal delivery patch for administration of a biologically active compound, the composition comprising a phosphate compound of tocopherol and a polymer carrier.Type: ApplicationFiled: November 21, 2013Publication date: June 5, 2014Applicant: PHOSPHAGENICS LIMITEDInventors: Jeremy Cottrell, Giacinto Gaetano, Mahmoud El-Tamimy, Nicholas Kennedy, Paul David Gavin
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Patent number: 8741321Abstract: A capsule for cosmetic and/or dermatological ingredients and processes for the production thereof. The capsule comprises an envelope which is solid, semisolid and/or dimensionally stable and comprises one or more substances which are selected from waxes, emulsifiers, and natural and synthetic polymers. The capsule may also comprise a filling.Type: GrantFiled: August 27, 2004Date of Patent: June 3, 2014Assignee: Beiersdorf AGInventors: Volker Kallmayer, Jens Nielsen, Andreas Bleckmann, Heidi Riedel, Julia Eckert, Thomas Raschke, Frank Teuber, Corinna Zu Putlitz, Stephanie Conzelmann, Kathrin Liste, Uta Kruse, Yvonne Eckharol
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Publication number: 20140147510Abstract: Provided herein are methods of making and controlling multiphasic polymeric micro-components capable of shape-shifting. Such a multiphasic micro-component comprises a first phase (that can include a first polymer) and at least one additional phase distinct from said first phase (that can include a second polymer). One or more of the first phase and additional phase comprises a component that is responsive to an external stimulus. Thus, the micro-component exhibits a substantial physical deformation in response to: (i) the presence of the external stimulus or (ii) a change in the external stimulus. Exemplary external stimuli include temperature, pressure, light, pH, ionic strength, hydrophobicity/hydrophilicity, solvent, concentration, a stimulator chemical, sonic energy, electric energy, pressure, magnetic fields, and combinations thereof.Type: ApplicationFiled: October 27, 2011Publication date: May 29, 2014Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: Joerg Lahann, Jaewon Yoon, Srijanani Bhaskar, Kyungjin Lee
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Publication number: 20140148514Abstract: This disclosure relates to an aliphatic-aromatic copolyester of poly(butylene-co-adipate terephthalate) that is prepared from recycled polyethylene terephthalate in the presence of titanium catalyst and a phosphorous containing compound. The copolyester is contaminated with little or no ethylene glycol and/or isophthalic acid, which are artifacts of preparing the copolyester from recycled PET. Advantageously, because there is little or no contamination from ethylene glycol and/or isophthalic acid in the copolyester, there is essentially no depression in the material's melting temperature.Type: ApplicationFiled: January 31, 2014Publication date: May 29, 2014Inventors: HUSNU ALP ALIDEDEOGLU, Ganesh Kannan