Carbohydrate Or Lignin, Or Derivative Patents (Class 514/777)
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Publication number: 20130045243Abstract: Described herein are materials and methods for the delivery of siRNA and the production of nanoparticles useful for the delivery of siRNA. Methods of treating a disease or disorder using the nanoparticles described herein also are disclosed.Type: ApplicationFiled: July 10, 2012Publication date: February 21, 2013Inventors: Ancha V. Baranova, Amanda C. Zirzow
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Publication number: 20130045182Abstract: Polysaccharide based hydrogel compositions and methods of making and using the same are provided. The subject polysaccharide based hydrogel compositions are prepared by combining a polysaccharide component with a hydrophilic polymer and a cross-linking agent. Also provided are kits and systems for use in preparing the subject compositions.Type: ApplicationFiled: November 5, 2010Publication date: February 21, 2013Inventors: Glen Gong, Suresh Subraya Pai, Scott Robert Sershen
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Patent number: 8377470Abstract: A non-gelatin encapsulation system for liquid filled soft capsules, by nature of the carrier, the cationic-ionic balance of the carrier and the active ingredients, or the concentration of the active ingredients and excipients, are difficult or impossible to commercially encapsulate in gelatin capsules. In particular, the system is adapted for the encapsulation of highly basic, or alkaline, fills. The system provides for a predominantly starch and gelling carrageenan based shell, which displays high resistance to both concentrated fills and to alkaline fills, in particular, to those fills which contain the salt or salts of weak acids and strong bases.Type: GrantFiled: July 6, 2012Date of Patent: February 19, 2013Assignee: R.P. Scherer Technologies, LLCInventors: Keith E. Tanner, Rickey S. Shelley, Norman S. Stroud, Elizabeth Youngblood
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Patent number: 8378064Abstract: The present invention provides new biopolymers which mimic the properties of natural polysaccharides found in vivo. The inventive polysaccharides can be used as viscosupplements, viscoelastics, tissue space fillers, and/or anti-adhesive agents. Also provided are pharmaceutical compositions comprising the inventive polymers and methods of using them including, for example, in the treatment of arthritic and sport-injured knee joints; in reconstruction or cosmetic procedures, intervertebral disc repair, treatment of vocal cord problems, treatment of urinary incontinence, and prevention of adhesion formation following abdominal or gynecological surgery.Type: GrantFiled: May 18, 2007Date of Patent: February 19, 2013Assignee: Trustees of Boston UniversityInventors: Mark W. Grinstaff, Michel Wathier
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Publication number: 20130035403Abstract: The invention relates to cells, nucleic acids, and enzymes, the use thereof for producing sophorolipids, and methods for producing sophorolipids.Type: ApplicationFiled: October 19, 2010Publication date: February 7, 2013Applicant: Evonik Degussa GmbHInventors: Steffen Schaffer, Mirja Wessel, Anja Thiessenhusen
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Publication number: 20130029932Abstract: A composition for external use on skin that can be spread evenly on the skin, does not produce a liquid residue as a result of temperature change, and can suppress a feeling of sliminess of xanthan gum is provided. There are provided a composition for external use on skin containing 0.1% by mass to 10% by mass of a component (A) (a water-soluble polymer obtained by mixing agar with xanthan gum) and 30% by mass or more of a component (D) (water); the composition for external use on skin containing 0.5% by mass to 40% by mass of a divalent polyol as a component (B); the composition for external use on skin according to any one of the above compositions, which contains moisturizers as a component (C); and the composition for external use on skin according to any one of the above compositions, which contains oil as a component (E).Type: ApplicationFiled: March 14, 2011Publication date: January 31, 2013Applicant: This Nisshin Oillio Group, Ltd.sInventors: Hisanori Kachi, Makoto Matsuzawa, Minaho Ookubo, Keiichi Oyama, Aki Gotou, Masaaki Kojima, Takehiko Sakai, Junichi Itou
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Publication number: 20130028955Abstract: A solid dosage form suitable for forming a tablet for the containment and delivery of medicament is provided wherein the matrix forming material is a pressure sensitive adhesive, present in the amount from about 0.1 to about 40 weight %, based on the total weight of the composition. The dosage form is comprised of the medicament and a water-insoluble polymer silicone pressure sensitive adhesive and allows release of the medicament in a controlled fashion depending on simple parameters such as weight percent of the polymer silicone adhesive. A sustained release dosage form is provided for delivery of medicament wherein the release rate of medicament does not depend on the dissolution medium of the pH. Another aspect of invention is formation of solid tablets of poorly compressible material and the method for making the solid composition. The dosage form for this invention s particularly suitable for oral dosage forms.Type: ApplicationFiled: July 25, 2011Publication date: January 31, 2013Inventor: Gaurav Thakersi Tolia
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Publication number: 20130030060Abstract: Glucosyl stevia compositions are prepared from steviol glycosides of Stevia rebaudiana Bertoni. The glucosylation was performed by cyclodextrin glucanotransferase using the starch as source of glucose residues. The short-chain glucosyl stevia compositions were purified to >95% content of total steviol glycosides. The compositions can be used as sweetness enhancers, flavor enhancers and sweeteners in foods, beverages, cosmetics and pharmaceuticals.Type: ApplicationFiled: October 22, 2012Publication date: January 31, 2013Applicant: PURECIRCLE USAInventor: PureCircle USA
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Publication number: 20130028934Abstract: The present invention relates to stabilizers for compositions, including immunogenic compositions, such as vaccine compositions, comprising one or more live attenuated flaviviruses, to bulk vaccine compositions stabilized with these stabilizers, particularly dry vaccine compositions prepared from these bulk vaccine compositions, and to methods for stabilizing one or more live attenuated flaviviruses.Type: ApplicationFiled: March 26, 2012Publication date: January 31, 2013Applicant: Sanofi PasteurInventors: Alain Françon, Olivier Brass, Pierre Chouvenc, Amandine Leleu
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Patent number: 8362088Abstract: An apparatus, system, and method are disclosed for encapsulating a homeopathic ingredient with a second ingredient. A homeopathic carrier is prepared by applying the homeopathic ingredient to at least one element. The element is selected from the second ingredient, an excipient, and a capsule assembly. The second ingredient is encapsulated in a closed capsule assembly. The closed capsule assembly comprises the homeopathic carrier.Type: GrantFiled: December 13, 2007Date of Patent: January 29, 2013Inventors: W. Matthew Warnock, Shane Hinze
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Publication number: 20130023509Abstract: Hyaluronic acid (HA) conjugates or crosslinked HAs compositions for coating an implantable device are provided. The implantable device can be used for treating a disorder such as atherosclerosis, thrombosis, restenosis, high cholesterol, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof.Type: ApplicationFiled: September 28, 2012Publication date: January 24, 2013Applicant: ADVANCED CARDIOVASCULAR SYSTEMS, INC.Inventor: ADAVANCED CARDIOVASCULAR SYSTEMS,IN
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Publication number: 20130023508Abstract: Hyaluronic acid (HA) conjugates or crosslinked HAs compositions for coating an implantable device are provided. The implantable device can be used for treating a disorder such as atherosclerosis, thrombosis, restenosis, high cholesterol, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof.Type: ApplicationFiled: September 28, 2012Publication date: January 24, 2013Applicant: ADVANCED CARDIOVASCULAR SYSTEMS, INC.Inventor: ADVANCED CARDIOVASCULAR SYSTEMS, IN
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Publication number: 20130023507Abstract: Hyaluronic acid (HA) conjugates or crosslinked HAs compositions for coating an implantable device are provided. The implantable device can be used for treating a disorder such as atherosclerosis, thrombosis, restenosis, high cholesterol, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof.Type: ApplicationFiled: September 28, 2012Publication date: January 24, 2013Applicant: ADVANCED CARDIOVASCULAR SYSTEMS, INC.Inventor: ADVANCED CARDIOVASCULAR SYSTEM, INC.
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Publication number: 20130017232Abstract: The disclosure provides Bone-mimetic mineral/polymer composite materials useful for formation of artificial bone grafts and for bone tissue engineering. The disclosure provides a hydrogels, cryogels and macroporous compositions modified with varying lengths of anionic pendant side chains (CH2?CHCONH(CH2)nCOOH, where n=1 to 12).Type: ApplicationFiled: July 13, 2012Publication date: January 17, 2013Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Shyni Varghese, Ameya Phadke
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Publication number: 20130012599Abstract: A surface treatment for the preparation of gasified consumable materials comprising active ingredients. The surface treatment may comprise a combination of flavors, sweeteners, and active ingredients such as nutritional supplements and/or pharmaceuticals. The invention avoids the degradation of active ingredients during the manufacturing process since the active ingredients are applied to the surface of the composition and not cooked with the gasified consumable material. Methods for making and using the disclosed compositions are also within the scope of the invention.Type: ApplicationFiled: August 3, 2011Publication date: January 10, 2013Inventors: LYNN HESSON, Bruce Howe, Vincent Duprat
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Publication number: 20130005740Abstract: Disclosed herein is a process producing a therapeutic comestible gummie product, the process comprises providing a sugar and/or sugar alcohol, water and heating to at least 80° C. to produce a first mixture. A gelling agent and water is also provided and heat to at least 80° C. to produce a second mixture. Combining the first and second mixtures to produce a slurry. The slurry is heated to at least 112° C. to produce a gummie base. The gummie base is cooled to an optimal temperature of below 90° C. for the addition of an active drug and the active drug is substantially uniformly mixed with the gummie base. In some embodiments the active is drug is mixed with an ingestible oil and added to the cooling slurry. The gummie base and active drug mixture is then poured into molding trays and allowed to cure. Also disclosed herein by way the process of the present disclosure is therapeutic comestible gummie product.Type: ApplicationFiled: August 5, 2010Publication date: January 3, 2013Applicant: 7267207 CANADA LIMITED CORPORATIONInventors: Stuart A. Lowther, Real Plante, Bradley H. Pilon, Mark A. Tarnopolsky
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Publication number: 20130005643Abstract: The present invention relates to a method for preparing nano-particles, and more particularly, to a method for preparing nano-particles containing active materials in a simple and highly efficient manner through a grinding process.Type: ApplicationFiled: March 22, 2011Publication date: January 3, 2013Applicant: Bio-Synetics Inc.Inventors: Kab Sig Kim, Joo Won Park
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Publication number: 20130004592Abstract: The invention comprises various aqueous PEG-carbohydrate-lipid based formulations of pharmaceutical active ingredients including compositions for intravenous injections. This invention relates to methods and compositions for improving solubility and the safety profile of pharmaceutical compounds. More particularly, the present invention relates to employing PEG-carbohydrate-lipid conjugates for formulating drug compositions having increased solubility or dispersivity and enhanced stability.Type: ApplicationFiled: June 25, 2012Publication date: January 3, 2013Inventor: Nian Wu
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Publication number: 20130005831Abstract: The present disclosure provides rapidly dissolving oral capsules and films comprising pullulan, a plasticizer, and a dissolution enhancing agent.Type: ApplicationFiled: December 22, 2011Publication date: January 3, 2013Applicant: UNIVERSITY OF KANSASInventors: Roger A. Rajewski, Lian G. Rajewski, John L. Haslam
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Publication number: 20130004604Abstract: An edible, chewable dark chocolate candy for the oral delivery of dietary supplements and pharmaceutical compounds. The-chocolate formed or molded solid candy contains at least one active ingredient that is blended with the chocolate candy during conching of the chocolate candy. A method for manufacturing the chewable chocolate candy is also disclosed. In the blending phase, a chocolate liquor is blended with additional ingredients to obtain the desired individual chocolate recipe for the chocolate delivery vehicle. The selected dietary supplement and/or pharmaceutical compounds are then added to the chocolate liquor, which is then conched for the desired time period. When the conching phase is completed, the conched chocolate is tempered, after which the tempered chocolate having 60% or more cacao mass may be formed into various sizes and shapes for individually-wrapped pieces, or formed into large blocks for storage and shipment.Type: ApplicationFiled: June 7, 2012Publication date: January 3, 2013Applicant: HERO NUTRITIONAL PRODUCTS LLCInventor: Judy Davis
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Patent number: 8343543Abstract: Pharmaceutical compositions that contain a lipase inhibitor having a melting point ?37° C., a sucrose fatty acid ester wherein the sucrose fatty acid ester is a mono-, di-, tri- or tetra-ester, and optionally one or more pharmaceutically acceptable excipients, are useful for treatment of obesity.Type: GrantFiled: August 19, 2011Date of Patent: January 1, 2013Assignee: Hoffmann-La Roche Inc.Inventors: Karsten Maeder, Rainer Eugen Martin, Susanne Raab, Lukas Christoph Scheibler, Thomas Schindler, Marco Schroeder
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Publication number: 20120328538Abstract: The present disclosure describes a replacement for petroleum jelly as a base for products which is suitable for most any application for which petroleum jelly can be used. The jelly is a glycerine based jelly composition comprising; vegetable derived glycerine and an emulsifier, wherein the emulsifier can be any known and/or commercially available glucoside containing emulsifier. Other suitable emulsifiers together with glycerine and essential or vegetable based oils with or without inorganic fillers may also be added to the jelly to impart fragrance, color, UVA and UVB sun protection factor(s), immuno-enhancing aromatherapeutics, as well as free radical scavenging constituents. In addition, temperature stabilizers and stiffening agents such as waxes and other inorganic fillers including silica and clays may also be added during manufacture as required. The glycerine is preferably present in the range of 50-95%.Type: ApplicationFiled: December 9, 2010Publication date: December 27, 2012Inventors: Guerry L. Grune, William Wingfield
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Publication number: 20120329738Abstract: Enhanced methods have been discovered, using either sonication or homogenization followed by increased temperature and pressure, to solubilize compounds using diterpene glycosides and to produce a powder form of the compound-solubilizer complex than can be reconstituted in water. Without the diterpene glycoside, the compounds were insoluble or sparingly soluble in water, including some fat-insoluble vitamins. Water solutions of these compounds were made using a diterpene glycoside solubilizer, for example, rubusoside. The compound-solubilizer complex was then dehydrated to a stable powder that could then be reconstituted with water. A reconstituted drug-solubilizer complex (curcumin-rubusoside) was shown to be effective on reconstitution. In addition, the diterpene glycoside, rubusoside, was shown to be an inhibitor of permeability glycoprotein (P-gp), and will thus increase gastrointestinal absorption of certain drugs administered with rubusoside.Type: ApplicationFiled: October 15, 2010Publication date: December 27, 2012Inventor: Zhijun Liu
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Publication number: 20120321596Abstract: A kit for bonding to biological hard tissues, containing a phosphorylated polysaccharide, a polyvalent metal salt other than phosphates, and a solvent. The adhesive composition for biological hard tissues provided by the kit for bonding to biological hard tissues is suitably used in for medical uses, such as cement for bones or dental cement.Type: ApplicationFiled: February 22, 2011Publication date: December 20, 2012Applicants: Junsei Educational Institution, National University Corporation Okayama UniversityInventors: Yasuhiro Yoshida, Masato Tanaka, Kazuomi Suzuki, Toshifumi Ozaki, Tomohiro Takahata, Masao Irie, Mariko Nakamura, Mitsunobu Kawashima, Yamato Nojiri, Koichi Okada, Masahiro Nagao
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Publication number: 20120321603Abstract: A composition and treatment method are disclosed for one or more of alpha, beta, and gamma-Cyclodextrin and a natural molecule or fragment thereof wherein the natural molecule is sometimes Glutathione, is non-acetylated, non-Esterified, and non-fatty acid attached, and the composition is administered parenterally and non-interveneously.Type: ApplicationFiled: June 18, 2012Publication date: December 20, 2012Inventors: Nayan Patel, Chinh Tran
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Publication number: 20120322750Abstract: Described is a solubilization agent for solubilizing polyphenols, flavonoids and/or diterpenoid glucosides in aqueous liquids, wherein the solubilization agent consists of a mixture of: (a) one emulsifying polymer or a mixture of two, three or more emulsifying polymers, (b) one saponin or a mixture of two, three or more saponins, (c) one partially or fully water-miscible, preferably liquid, solvent or a mixture of partially or fully water-miscible, preferably liquid, solvents, preferably selected from the group consisting of ethanol, propylene glycol (1,2-propanediol), glycerin, triacetin (glycerin triacetate), diacetin (glycerin diacetate) and triethyl citrate, and (d) water. The solubilization agent is particularly suitable for sparingly water soluble polyphenols, flavonoids and/or diterpenoid glucosides. The invention also relates to compositions and (food or cosmetic) formulations comprising said solubilization agent.Type: ApplicationFiled: January 24, 2011Publication date: December 20, 2012Applicant: SYMRISE AGInventors: Dirk Schrader, Thomas Riess, Cornelia Homner, Christopher Sabater-Lüntzel
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Patent number: 8333962Abstract: A controlled release multidrug formulation for improving locomotor recovery after spinal cord injury comprising: (a) a first composition comprising a first bioactive agent, encapsulated within a first polymeric particle; (b) a second composition comprising a second bioactive agent, encapsulated within a second polymeric particle, wherein the second polymeric particle is encapsulated within the first polymeric particle; and (c) a third composition comprising a third bioactive agent, encapsulated within either the first or the second polymeric particle, wherein the second composition is released subsequently to the release of the first composition, and wherein the first bioactive agent is a neurotrophic factor, the second bioactive agent is a collagen synthesis inhibitor, and the third bioactive agent is selected from the group consisting of cyclic AMP (cAMP), an adenylate cyclase activator and a Rho inhibitor.Type: GrantFiled: August 27, 2009Date of Patent: December 18, 2012Assignee: National Health Research InstitutesInventors: Yu-Chao Wang, Yi-Ting Wu, Chung-Shi Yang
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Publication number: 20120316108Abstract: The present invention is directed to compositions and methods of preparation of phospholipid depots that are injectable through a fine needle.Type: ApplicationFiled: June 14, 2012Publication date: December 13, 2012Applicant: Latitude Pharmaceuticals Inc.Inventors: Andrew Xian Chen, Hailiang Chen
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Publication number: 20120316520Abstract: A transdermal therapeutic system for administering lipophilic, poorly water-soluble and/or sparingly skin-permeable pharmaceutical active substances. The active substance is present in a multi-component enhancer system consisting of 4 components and each component of the multi-component enhancer system is selected from a different one of the substance groups: a) terpenes, b) cyclic glucitol ethers, c) medium-chain triglycerides of capric and caprylic acid and/or of linoleic acid; and d) longer-chain alcohols having a chain length of 8 or more carbon atoms.Type: ApplicationFiled: August 22, 2012Publication date: December 13, 2012Applicant: LTS LOHMANN THERAPIE-SYSTEME AGInventors: Andreas Koch, Christoph Schmitz, Rolf Pracht, Mohammad Sameti
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Publication number: 20120309854Abstract: Compositions comprising compounds having an aldohexose moiety, a highly fluorinated moiety, and a nitrogen-containing functional group linking the moieties together are disclosed. The aldohexose-based fluoroadditives are effective in reducing the surface tension of water and are useful in various surfactant applications. Also disclosed are processes for making aldohexose-based fluoroadditives.Type: ApplicationFiled: May 14, 2012Publication date: December 6, 2012Applicant: E I DU PONT DE NEMOURS AND COMPANYInventors: ANILKUMAR RAGHAVANPILLAI, Stefan Reinartz
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Publication number: 20120309853Abstract: Compositions comprising compounds having an aldohexose moiety, a highly fluorinated moiety, and a nitrogen-containing functional group linking the moieties together are disclosed. The aldohexose-based fluoroadditives are effective in reducing the surface tension of water and are useful in various surfactant applications. Also disclosed are processes for making aldohexose-based fluoroadditives.Type: ApplicationFiled: May 14, 2012Publication date: December 6, 2012Applicant: E I DU PONT DE NEMOURS AND COMPANYInventors: ANILKUMAR RAGHAVANPILLAI, Stefan Reinartz
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Publication number: 20120308613Abstract: A formulation for an inhaler device comprises carrier particles having a diameter of at least 50 ?m and a mass median diameter of at least 175 ?m; active particles; and additive material to which is able to promote release of the active particles from the carrier particles on actuation of the inhaler device. The formulation has excellent flowability even at relatively high fine particle contents.Type: ApplicationFiled: April 25, 2012Publication date: December 6, 2012Applicant: VECTURA LIMITEDInventors: John Nicholas Staniforth, David Alexander Vodden Morton, Rajbir Gill, Gaetano Brambilla, Rossella Musa, Lorenzno Ferrarini
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Publication number: 20120308492Abstract: The present invention relates to foamable oil-in-water emulsions containing: A) one or more emulsifiers, at least one of which is a non-ionic emulsifier, B) one or more cotensides, C) one or more oils, D) optionally, one or more polar solubilizers, E) optionally, auxiliary and additive substances, F) one or more surfactants, G) water, H) optionally, water-soluble substances, provided that the water content of the emulsion is ?70% by weight and the concentration of surfactant(s) F) is from 0.01 to less than 10% by weight, each based on the entire emulsion. The invention further relates to a method for producing the oil-water emulsions according to the invention, to foams obtained from these oil-water emulsions, to a method for producing the foams, and to the application of the oil-water emulsions according to the invention and to the foams produced therefrom.Type: ApplicationFiled: June 30, 2010Publication date: December 6, 2012Applicant: EVONIK STOCKHAUSEN GMBHInventors: Petra Allef, Marcel Veeger, Volker Klotzbach
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Publication number: 20120301546Abstract: The present disclosure describes a delivery device for administration of nutraceuticals or pharmaceuticals, which device contains a soft gel shell comprising a gelatin-based water soluble film forming polymer, an acid insoluble polymer, and at least one reducing sugar and water, including processes, gel mixtures used for device production, and coatings containing such gel mixtures.Type: ApplicationFiled: May 26, 2011Publication date: November 29, 2012Inventor: Emadeldin M. Hassan
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Publication number: 20120302816Abstract: The present invention pertains to therapeutic compositions that comprise: (1) a nanovector, (2) an active agent; and (3) a targeting agent, wherein the active agent and the targeting agent are non-covalently associated with the nanovector. The present invention also pertains to methods of treating various conditions in a subject by utilizing the above-described therapeutic compositions. Methods of making the therapeutic compositions are also a subject matter the present invention.Type: ApplicationFiled: October 27, 2010Publication date: November 29, 2012Applicant: William Marsh Rice UniversityInventors: James M. Tour, Jacob Berlin, Tam Pham, Jeffrey N. Myers, Daisuke Sano
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Publication number: 20120301441Abstract: The invention provides a copolymer of hyaluronic acid (HA) grafted with a dextran-tyramine (Dex-TA) conjugate.Type: ApplicationFiled: November 11, 2010Publication date: November 29, 2012Inventors: Hermanus Bernardus Johannes Karperien, Rong Jin, Liliana Sofia Moreira Teixeira, Jan Feijen, Pieter Jelle Dijstra
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Publication number: 20120301516Abstract: Porous materials and methods for forming them are disclosed. One method for immobilizing micro-particles and/or nano-particles onto internal pore surfaces and/or external pore surfaces of porous materials includes suspending the micro-particles and/or nano-particles in a liquid adapted to swell, soften, and/or deform either the porous materials and/or the particles, thereby forming a liquid-particle suspension. The method further includes adding the suspension to the porous materials; and removing the liquid, thereby forming the porous materials having the micro-particles and/or nano-particles immobilized on the internal pore surfaces and/or the external pore surfaces.Type: ApplicationFiled: August 2, 2012Publication date: November 29, 2012Inventors: Peter X. Ma, Guobao Wei
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Patent number: 8318818Abstract: A tropical composition is provided. The topical composition can be prepared by diluting a topical composition precursor with water and adding additional components, if desired. The topical composition precursor can be prepared by melt processing a hydrophobic polymer composition that includes repeating pyrrolidone/alkylene groups wherein the alkylene groups contain at least 10 carbon atoms, and a hydrophilic polymer composition including repeating carboxylic groups and/or repeating hydroxyl groups. A topical composition precursor and methods for manufacturing and using a topical composition are provided by the invention.Type: GrantFiled: March 14, 2005Date of Patent: November 27, 2012Assignee: Skinvisible Pharmaceuticals, Inc.Inventors: James A. Roszell, Bruce Jezior
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Publication number: 20120294940Abstract: The present invention provides a method of suppressing the bitter taste of a drug when a rapidly disintegrating tablet in an oral cavity is produced. When a rapidly disintegrating tablet in an oral cavity is produced, the bitter taste of a drug is suppressed by utilizing (a) a granule which contains a drug having a bitter taste and an excipient and in which the bitter taste has not been suppressed and (b) a granule containing a water soluble saccharide.Type: ApplicationFiled: August 3, 2012Publication date: November 22, 2012Inventors: Katsuji UEMURA, Masaaki SUGIMOTO, Shinya TAKATSUKA, Toshinobu KOMORI
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Publication number: 20120294903Abstract: In accordance with the purpose(s) of the present disclosure, as embodied and broadly described herein, embodiments of the present disclosure, in one aspect, relate to methods of making nanostructures (e.g., nanoparticles, nanofibers), systems for making nanostructures, and the like.Type: ApplicationFiled: April 27, 2012Publication date: November 22, 2012Applicants: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC., The Board of Trustees of the Leland Stanford Junior UniversityInventors: Peng Guo, Charles R. Martin, Yaping Zhao, Richard N. Zare
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Publication number: 20120294893Abstract: The present invention aims to provide a jelly (as a result, easy-to-swallow), intraorally soluble edible jelly composition although it is preferably free of water. The present invention relates to an edible jelly composition including: a gelling agent; and a nonvolatile organic solvent compatible with the gelling agent.Type: ApplicationFiled: May 18, 2012Publication date: November 22, 2012Applicant: NITTO DENKO CORPORATIONInventors: Daisuke ASARI, Takuya SHISHIDO, Mitsuhiko HORI, Kyohei MATSUSHITA
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Publication number: 20120295833Abstract: An anionic polysaccharide comprising carboxylic acid functional groups of formula I: in which: the polysaccharide may be either, synthetic or modified, i represents the degree of functionalization of the hydroxyls, j represents the degree of functionalization of the hydroxyls, L and Q represent an optionally branched and/or unsaturated chain comprising from 1 to 15 carbons, F is a functional group chosen from the group consisting of the carbamate functional group, the carbonyl being bonded to the Q radical, the ester functional group, the carbonyl being bonded to the Q radical, the amide functional group, the carbonyl being bonded to the Q radical, and the carboxylate functional group, and Grp is chosen from the group consisting of a mono- or divalent cation and of a chain comprising from 4 to 50 carbons.Type: ApplicationFiled: May 10, 2012Publication date: November 22, 2012Applicant: ADOCIAInventors: Richard CHARVET, Guilhem MORA, Rémi SOULA
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Publication number: 20120289559Abstract: Disclosed is a manufacturing method for a fine powder exhibiting improved solubility, little impurity contamination, and a high recovery rate. Material to be ground and a grinding medium are suspended and stirred in a liquefied inert gas dispersion medium such as dried ice, and the material to be ground is made into a sub-micron or nano-sized fine powder. A uniform fine powder can be obtained when the material to be ground is a mixture having two or more components. Impurity contamination can be reduced by using granular dry ice as the grinding medium.Type: ApplicationFiled: November 12, 2010Publication date: November 15, 2012Inventors: Toshiyuki Niwa, Shohei Sugimoto, Kazumi Danjo, Masaaki Nishio, Yasuo Nakanishi, Sakiko Kawamura
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Publication number: 20120289612Abstract: It has been necessary to use a relatively large amount of cyclodextrin in order to produce a composite material, but the amount of the cyclodextrin needs to be reduced from the viewpoint of costs; in this respect, the present invention provides a composite material comprising a food or active pharmaceutical ingredient, a phytosterol ester, a medium-chain fatty acid triacylglyceride, and a cyclodextrin.Type: ApplicationFiled: April 13, 2012Publication date: November 15, 2012Applicant: HOUSE FOODS CORPORATIONInventors: Tadashi Hamajima, Masaki Nakamura
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Publication number: 20120289611Abstract: Briefly described, embodiments of the present disclosure provide for compositions including pectin compounds, pectin compounds, methods of making pectin compounds, methods of controlling the water solubility of a pectin compound, methods of controlling the water solubility of an agent, beads including pectin compounds, and the like.Type: ApplicationFiled: September 29, 2010Publication date: November 15, 2012Inventors: Daniel T. Daly, Scott K. Spear, Richard P. Swatloski
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Publication number: 20120288540Abstract: The present invention relates to a vesicular structure formed of a mixture of a non-ionic surfactant and cholesterol, characterised in that it is freeze-dried in the presence of a cryoprotectant, to a method for the preparation and to the use thereof.Type: ApplicationFiled: January 5, 2011Publication date: November 15, 2012Applicants: UNIVERSITÀ DEGLI STUDI "MAGNA GRAECIA" CATANZARO, UNIVERSITÀ DEGLI STUDI DI ROMA "LA SAPIENZA"Inventors: Maria Carafa, Franco Alhaique, Carlotta Marianecci, Donatella Paolino, Massimo Fresta
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Publication number: 20120289469Abstract: Methods and compositions for maintaining an active agent in an intra-articular space are disclosed. Methods of delivering the compositions to an intra-articular space and methods of making the compositions also are disclosed. The compositions comprise an active agent and a polymer comprising at least one cationic group. A fluid including the composition may be injected into an intra-articular space in a human or animal whereby the composition associates with endogenous material in the intra-articular space. In some embodiments, the fluid further comprises a poorly aqueous soluble polymer.Type: ApplicationFiled: May 10, 2012Publication date: November 15, 2012Inventors: Michael M. Morgen, Warren K. Miller
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Publication number: 20120288562Abstract: The present invention relates to new acid resistant hard pharmaceutical capsules, a process for their manufacture and use of such capsules particularly but not exclusively for oral administration of pharmaceuticals, veterinary products, food and dietary supplements to humans or animals. The capsules of the invention are obtained by aqueous compositions comprising a water soluble film forming polymer and gellan gum in a mutual weight ratio of 4 to 15 weight parts of gellan gum for 100 weight parts of film forming polymer.Type: ApplicationFiled: September 14, 2010Publication date: November 15, 2012Inventors: Dominique Nicolas Cade, Xiongwei David He
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Publication number: 20120288491Abstract: Solid dry powder compositions comprising active agents and dextran polymer derivatives comprising an ester-linked amine-containing substituent and an alkyl ester substituent are disclosed, as are methods for making such compositions.Type: ApplicationFiled: May 10, 2012Publication date: November 15, 2012Inventors: Warren K. Miller, Michael M. Morgen, Corey J. Bloom
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Publication number: 20120288529Abstract: The present invention relates to a pharmaceutical excipient comprising a mixture of sugar alcohol and chitin and/or chitin derivatives, a method for its preparation and use thereof.Type: ApplicationFiled: May 11, 2011Publication date: November 15, 2012Applicant: THE JORDANIAN PHARMACEUTICAL MANUFACTURING CO.Inventors: Nidal H. Daraghmenh, Mahmoud M. Al Omari, Adnan A. Badwan