Anesthetic, Topical Patents (Class 514/817)
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Patent number: 6413987Abstract: The present invention relates to new aminoindane piperidine compounds, the method of using aminoindane compounds as local anesthetics, said compounds having particularly valuable properties as dermal and topical anesthetics in mammals, including man, as well as compositions containing said compounds.Type: GrantFiled: June 6, 2000Date of Patent: July 2, 2002Assignee: Bridge Pharma, Inc.Inventors: A. K. Gunnar Aberg, George E. Wright, Jan L. Chen
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Publication number: 20020058048Abstract: A topical capsaicin preparation for the treatment of painful cutaneous disorders and neural dysfunction is disclosed. The preparation contains a nonionic, amphoteric or cationic surfactant in an amount effective to eliminate or substantially ameliorate burning pain caused by capsaicin.Type: ApplicationFiled: November 12, 1999Publication date: May 16, 2002Inventors: TAKASHI TAMURA, URAO KAWAKAMI, YUICHI TERATANI, MASAKAZU YOSHIMURA, MASAHIKO SETO
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Patent number: 6379713Abstract: A method of treatment for a mammal in need of analgesia from an itching skin comprising applying by directional friction against the skin proximate to the itch a composition consisting essentially of dry elemental iodine in the form of an amorphous condensate. The method is found effective in producing analgesia to the affected skin within 1 to 5 minutes after application.Type: GrantFiled: March 23, 2001Date of Patent: April 30, 2002Inventor: André Reiss
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Patent number: 6365131Abstract: Pharmaceutical dental gel preparation comprising of metronidazole benzoate, chlorhexidine gluconate, and local anesthetic as the active ingredient; glycol as the solvent medium; a carboxyvinyl polymer, cross-linked polymer of acrylic acid copolymerized with polyalkylsucrose as a gelling agent.Type: GrantFiled: January 10, 2000Date of Patent: April 2, 2002Assignee: J. B. Chemicals & Pharmaceuticals Ltd.Inventors: Madhukant Mansukhlal Doshi, Milind Dattatraya Joshi, Bharat Pravinchandra Mehta
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Patent number: 6361319Abstract: A method of decreasing the permeabilty of dentin by the application of an effective amount of oxalic acid potassium salt, dihydrate in an aqueous solution at a pH of about 2.0 to 4.0 to the dentin.Type: GrantFiled: December 20, 2000Date of Patent: March 26, 2002Inventor: Charles E. Cox
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Patent number: 6355705Abstract: A polymethacrylate or other bone cement composition having analgesic properties is described. Bone cements containing up to 5% by weight of a local anaesthetic agent, such as lidocaine, have been demonstrated to elute sufficient lidocaine to provide an analgesic effect in vivo.Type: GrantFiled: April 1, 1997Date of Patent: March 12, 2002Assignee: Queen's University at KingstonInventors: David M. Bond, John F. Rudan
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Patent number: 6350465Abstract: A method of treating headaches by blocking the sphenopalatine ganglion comprises using a first device to anesthetize a front portion of the nasal cavity. A second device is used to anesthetize a rear portion of the nasal cavity. After these priming anesthetizations, a primary pain medication delivery device is used to discharge an anesthetic to the sphenopalatine ganglion to treat the headache.Type: GrantFiled: January 17, 2001Date of Patent: February 26, 2002Inventors: Murali M. R. Jonnalagadda, Venkata Thirumala Devi-Jonnalagadda
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Patent number: 6340472Abstract: Methods and apparatus for improving administration of drugs through the use of heat and other physical means. The present invention relates to the use of heat and other physical means in conjunction with specially designed dermal drug delivery systems, conventional commercial dermal drug delivery systems, or drugs delivered into a sub-skin depot site via injection and other methods to alter, mainly increase, the drug release rate from the dermal drug delivery systems or the depot sites to accommodate certain clinical needs.Type: GrantFiled: April 7, 2000Date of Patent: January 22, 2002Assignee: Zars, Inc.Inventors: Jie Zhang, Hao Zhang
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Patent number: 6337076Abstract: A method and composition for treating hypertrophic scars so as to reduce the size and approve the appearance of scars comprises applying to the scar a composition comprising a film-forming carrier such as a Collodion which contains one or more active ingredients such as a topical steroid, silicone gel and vitamin E. Novel compositions using the Collodion film-forming carrier are also useful to treat a variety of adverse skin disorders.Type: GrantFiled: November 17, 1999Date of Patent: January 8, 2002Assignee: SG Licensing CorporationInventor: Joel R. Studin
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Patent number: 6306431Abstract: Methods and apparatus for improving administration of drugs through the use of heat and other physical means. The present invention relates to the use of heat and other physical means in conjunction with specially designed dermal drug delivery systems, conventional commercial dermal drug delivery systems, or drugs delivered into a sub-skin depot site via injection and other methods to alter, mainly increase, the drug release rate from the dermal drug delivery systems or the depot sites to accommodate certain clinical needs.Type: GrantFiled: April 7, 2000Date of Patent: October 23, 2001Assignee: Zars, Inc.Inventors: Jie Zhang, Hao Zhang
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Patent number: 6303142Abstract: Methods and apparatus for improving administration of drugs through the use of heat and other physical means. The present invention relates to the use of heat and other physical means in conjunction with specially designed dermal drug delivery systems, conventional commercial dermal drug delivery systems, or drugs delivered into a sub-skin depot site via injection and other methods to alter, mainly increase, the drug release rate from the dermal drug delivery systems or the depot sites to accommodate certain clinical needs.Type: GrantFiled: April 7, 2000Date of Patent: October 16, 2001Assignee: Zars, Inc.Inventors: Jie Zhang, Hao Zhang
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Patent number: 6299902Abstract: A novel topical anesthetic preparation is characterized by improved transdermal absorption and efficacy. In a preferred embodiment, the topical preparation contains at least one local anesthetic agent and at least two melting point depressing agents. Also provided is a two-phase liquid composition that contains aqueous and oil phases, the oil phase having a relatively high concentration of a local anesthetic agent to enhance transdermal absorption and efficacy when incorporated into a topical anesthetic preparation. A preferred topical anesthetic preparation includes lidocaine or tetracaine, thymol or menthol, and ethyl alcohol or isopropyl alcohol. The preparation is expected to be safe and effective in obtaining transdermal anesthesia on intact skin and mucous membrane of adults, children, infants and newborns.Type: GrantFiled: July 19, 1999Date of Patent: October 9, 2001Assignee: The University of Georgia Research Foundation, Inc.Inventors: H. Won Jun, Lisheng Kang
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Patent number: 6297290Abstract: The present invention relates to a novel aqueous composition based on a compound modulating the reactivity of nerve fibers. It relates more particularly to a pharmaceutical composition for topical use on a human or animal body and intended to anesthetize the skin or the mucous membranes or to treat pruritus.Type: GrantFiled: September 4, 1998Date of Patent: October 2, 2001Assignee: Centre International de Recherches Dermatoloques Galderma (C.I.R.D. Galderma)Inventors: Anne-Emmanuelle Guise, Josiane Allec, Karen Ctorza
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Patent number: 6251371Abstract: The present invention relates to use of dichlorobenzyl alcohol for preparing a preparation for topical treatment of inflammation and the preparation for this purpose. It is known to use dichlorobenzyl alcohol (2,4-DCBA) as an agent against bacteria and fungi, i.e. as a disinfectant. By the present invention it has, however, surprisingly turned out that dichlorobenzyl alcohol, preferably 2,4-dichlorobenzyl alcohol, is also useful for treatment of inflammation. The invention also relates to a preparation containing dichlorobenzyl alcohol, preferably 2,4-dichlorobenzyl alcohol, for topical treatment of inflammation, which can be applied onto skin or mucosa in the form of an ointment, a cream, a gel or a solution. Thus, the preparation has turned out to be effective against a variety of inflammatory conditions including skin diseases, such as pruritus and psoriasis, insect bites and stings.Type: GrantFiled: August 30, 1999Date of Patent: June 26, 2001Assignee: Bifodan A/SInventors: Hans Holmen, Arne Martinus Pedersen
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Patent number: 6235265Abstract: Evaporative coolants suitable for use as cold spray topical anesthetics containing hydrofluorocarbons and/or hydrochlorofluorocarbons, preferably 1,1,1,3,3-pentafluoropropane, either alone or in combination with other hydrofluorocarbon and/or hydrochlorofluorocarbon components. The invention includes a system for cooling skin using the coolant and a device for spraying the coolant, as well as a method of cooling or topically anesthetizing the skin comprising spraying such evaporative coolants thereon.Type: GrantFiled: October 28, 1998Date of Patent: May 22, 2001Assignee: AlliedSignal Inc.Inventor: Peter B. Logsdon
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Patent number: 6231835Abstract: An aerosol preparation for skin-cooling which coagulates sherbet-like on the applied site when sprayed, comprising a liquefied gas and a concentrate containing a C1-3 lower alcohol and a C10-22 straight chain monocarboxylic acid can contain drugs labile in water of which the incorporation has been difficult in the previous aerosol preparations, gives a good feeling when used, and have a durable cooling effect. Accordingly, it is effective on quick calming the pain caused by contusion, sprain, muscular fatigue, etc. or the itch caused by athlete's foot, insect bite, etc.Type: GrantFiled: December 9, 1999Date of Patent: May 15, 2001Assignee: Taisho Pharmaceutical Co., Ltd.Inventor: Fuminori Kimura
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Patent number: 6203796Abstract: A therapeutic composition comprising oregano oil, laurel oil, and myrtle oil useful in alleviating pain and discomfort associated with arthritis, migraines, bronchitis, soft tissue injuries, muscle aches and pains and neck and back pains and strains in humans, as well as upper respiratory, joint and shin ailments in animals.Type: GrantFiled: July 8, 1999Date of Patent: March 20, 2001Inventor: Andreas D. Papaprodromou
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Patent number: 6166085Abstract: The invention relates to methods of producing analgesia, particularly in the treatment-of-acute and persistent pain and neuropathic pain. The compound 2(ethylamino)-N-(3-hydroxy-2,6-dimethylphenyl) acetamide, or 3-hydroxymonoethylglycinexylidide (3-hydroxy MEGX), is shown to provide analgesia in settings of acute, persistent and neuropathic pain.Type: GrantFiled: September 13, 1996Date of Patent: December 26, 2000Assignee: The Regents of the University of CaliforniaInventors: Sandra Reading Chaplan, Flemming Winther Bach, Tony Lee Yaksh
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Patent number: 6147102Abstract: Sympathetically maintained peripheral neuropathic pain syndromes are relieved by topically applying, to the affected region of a patient suffering from such pain, a pain relieving amount of an aqueous gel comprising clonidine, a water-gelling amount of a pharmaceutically acceptable gelling agent and having a physiologically tolerable pH value. Pain relief was achieved with applied amounts of clonidine in the range of about 2 milligrams per day to about 6 mg per day.Type: GrantFiled: October 26, 1999Date of Patent: November 14, 2000Assignee: Curatek Pharmaceuticals Holding, Inc.Inventor: Robert J. Borgman
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Patent number: 6143736Abstract: Methods, compositions, and compounds for modulating the GABA.sub.A receptor-chloride ionophore complex to alleviate stress, anxiety, seizures, mood disorders, PMS and PND and to induce anesthesia.Type: GrantFiled: July 8, 1999Date of Patent: November 7, 2000Assignee: CoCensys, Inc.Inventors: Ravindra B. Upasani, Haiji Xia, Derk Hogenkamp
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Patent number: 6133327Abstract: An aerosol preparation which when sprayed forms a sherbet-like solid, which comprises a concentrate containing a lower alcohol having 1 to 3 carbon atoms and a higher alcohol having at least 12 carbon atoms and a propellant containing a liquefied gas. Said aerosol preparation does not require any complicated emulsifying procedure for the production, can contain components labile in water and have a durable cooling effect, and therefore, it is quickly calmative on the pain caused by contusion, sprain, muscular fatigue, etc. and the itch caused by athlete's foot, insect bite, etc.Type: GrantFiled: June 12, 1998Date of Patent: October 17, 2000Assignee: Taisho Pharmaceutical Co., Ltd.Inventors: Fuminori Kimura, Tsuyoshi Uchiyama, Haruo Shimamura, Fumio Urushizaki
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Patent number: 6103257Abstract: The present invention is a system which topically delivers pharmaceuticals to the buccal mucosa. Preferred pharmaceuticals include topical local anesthetics, such as tetracaine, which can be applied to the mucosa for rapid pain relief. The system comprises a hard candy matrix in which the pharmaceutical is dispersed. The hard candy matrix may be formed without the addition of dyes, synthetic flavoring agents, alcohols, or preservatives. Also, the candy may be mounted on a handle to form a lollipop, and the handle may be used to position the candy adjacent a particular site where the pharmaceutical is needed.Type: GrantFiled: July 17, 1998Date of Patent: August 15, 2000Assignee: Num-Pop, Inc.Inventor: Keith Nisonoff
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Patent number: 6103771Abstract: Methods of treating a host suffering from neuroma pain are provided. In the subject methods, a topical local anesthetic composition is applied to a keratinized skin site of the host proximal to the neuroma responsible for the neuroma pain. Preferably, the topical local anesthetic composition comprises eucalyptol in addition to an effective amount of a local anesthetic. The subject methods find particular use in the treatment of pain associated with Morton's neuroma.Type: GrantFiled: March 20, 1998Date of Patent: August 15, 2000Assignee: Caldwell Galer IncorporatedInventors: Bradley S. Galer, Larry J. Caldwell
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Patent number: 6074674Abstract: The present invention provides, inter alia, formulations useful to ameliorate symptoms associated with mucosal abrasions, specifically those due to dental orthodontic brackets; oral surgery; periodontal surgery or other procedures. For instance, there is a formulation comprising: 65 to 75% microcrystalline wax; 5 to 15% non-ionic polymer; 15 to 25% topical anesthetic; and 1 to 5% surfactant, wherein the ratio of non-ionic polymer to microcrystalline wax is no greater than 0.2. Preferably, for solid topical anesthetics, the particle size is less than the apertures of a 100-mesh screen. However, the topical anesthetic may also be a liquid. Formulations wherein the mixture is a homogeneous matrix is preferred.Type: GrantFiled: July 20, 1998Date of Patent: June 13, 2000Assignee: University of Kentucky Research FoundationInventors: Michael Joseph Jay, G. Thomas Kluemper, Sang Hun Kim
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Patent number: 6030974Abstract: A method of producing local anesthesia in a mammal experiencing pain in an epithelial tissue region is described. The method includes topically administering to the region, in a suitable pharmaceutical vehicle, an effective dose of a long-acting sodium channel blocking compound.Type: GrantFiled: April 2, 1998Date of Patent: February 29, 2000Assignee: The Regents of the University of CaliforniaInventors: Daniel M. Schwartz, Howard L. Fields
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Patent number: 6031007Abstract: The invention is directed to a novel pharmaceutical composition comprising one or more local anaesthetics in oil form, one or more surfactants, water and optionally a taste masking agent. The novel composition is advantageously used as a local anaesthetic for pain relief within the oral cavity.Type: GrantFiled: August 6, 1997Date of Patent: February 29, 2000Assignee: Astra ABInventors: Arne Brodin, Raymond Fynes, Lars Heijl, Adela Nyqvist-Mayer, Marie Scherlund
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Patent number: 6008256Abstract: A composition for local anesthesia which comprises (A) lidocaine, (B) a catecholamine such as epinephrine in an amount of, for example, 1/200,000 (g/ml) based on the volume of the composition, and (C) one or more amino acids such as glycine, glutamic acid, and L-glutamic acid-L-lysine or one or more hydroxycarboxylic acids such as lactic acid, glycolic acid, and citric acid, which has a duration suitable for short-time dental operations such as tooth extraction and excellent storage stability.Type: GrantFiled: February 27, 1998Date of Patent: December 28, 1999Assignee: Showa Yakuhin Kako Co., Ltd.Inventors: Mitsuhiro Haraguchi, Kazuhiro Ono, Takashi Osada, Yukio Suzuki
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Patent number: 6004566Abstract: The present invention relates to a delivery system which includes a bioactive drug or cosmetic substance presented in the form of submicron oil spheres alone, or drugs or cosmetic substances in a combination with the oil spheres in an aqueous suspension or emulsion. Optionally, a skin penetration enhancer may be included in such formulations. Such preparations achieve improved bioavailability and exert larger pharmacological effects than an equivalent dose of the drug or cosmetic formulated in conventional creams, lotions or oleaginous bases.Type: GrantFiled: March 23, 1993Date of Patent: December 21, 1999Assignee: Pharmos Corp.Inventors: Doron Friedman, Joseph Schwartz, Haim Aviv
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Patent number: 5993787Abstract: Entirely anhydrous topical preparations comprising (I) propylene carbonate, (II) one or more short carbon-chain alcohols and/or glycols including ethanol, isopropyl alcohol, propylene glycol, butylene glycol, polyethylene glycol, hexylene glycol, methoxypolyethylene glycol, and (III) either or both of glycerol and one or more therapeutically or cosmetically active ingredients.Type: GrantFiled: September 13, 1996Date of Patent: November 30, 1999Assignee: Johnson & Johnson Consumer Products, Inc.Inventors: Ying Sun, Jue-Chen Liu, Elisabeth S. Kimbleton, Jonas C. T. Wang
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Patent number: 5976504Abstract: Aerosol formulations for topical administration for cooling of mammalian tissues. The formulations are rapid onset and sustained effect, and further contain no CFCs and are nonflammable.Type: GrantFiled: June 12, 1996Date of Patent: November 2, 1999Assignee: The Boots Company, PLCInventor: Julian Paul Russell
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Patent number: 5948389Abstract: The present invention is a method for enhancing the analgesic efficacy of a locally applied opioid analgesic or local anesthetic agent in a mammal having an impermeable perineurium barrier sheet about the peripheral sensory nerves at the site of action of the analgesic or anesthetic agent. The method involves applying to that site an effective amount of the analgesic or anesthetic agent dissolved in a hyperosmolar solution having an osmolality of above 300 mOsm/l.Type: GrantFiled: September 3, 1997Date of Patent: September 7, 1999Assignee: El Khoury & Stein, Ltd.Inventor: Christoph Stein
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Patent number: 5942543Abstract: A topical anesthetic includes about 1-10% by weight lidocaine hydrochloride, about 0.01-0.10% by weight adrenaline, and about 0.25-4% by weight tetracaine hydrochloride, preferably in an aqueous base with about 2% benzyl alcohol or in a gel including about 3% hydroxyethyl cellulose. The topical anesthetic has been found to be at least as effective as TAC (tetracaine hydrochloride, adrenaline, cocaine), but with fewer harmful side effects and at a greatly reduced cost (about 1/10 of the cost of TAC).Type: GrantFiled: December 16, 1996Date of Patent: August 24, 1999Inventor: Amy A. Ernst
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Patent number: 5922340Abstract: A formulation for inducing sustained local anesthesia in a patient comprising a substrate comprising a high load of local anesthetic by weight and an effective amount of a biocompatible, controlled release material to obtain a reversible nerve blockade or anesthesia effect when implanted or injected in a patient, and a non-toxic glucocorticosteroid agent effective to prolong the duration of the local anesthesia for a time period longer than that obtainable from the substrate without the glucocorticosteroid agent.Type: GrantFiled: September 16, 1996Date of Patent: July 13, 1999Assignee: Children's Medical Center CorporationInventors: Charles B. Berde, Robert S. Langer, Joanne Curley, Jenny Castillo
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Patent number: 5919479Abstract: An apparatus, product formulation, and method for improved dermal permeation of pharmaceuticals wherein the apparatus includes a thin drug formulation reservoir and a heat-generating chamber separated by a first non-permeable wall, wherein the reservoir and chamber are formed in or supported by a housing. The drug formulation reservoir houses or is capable of housing a predetermined amount of a formulation containing pharmaceutically-active agent(s). The heat-generating/temperature-regulating chamber includes a medium for generating controlled heat, preferably a chemical composition made of carbon, iron, water and/or salt which is activated upon contact with air (oxygen).Type: GrantFiled: March 18, 1997Date of Patent: July 6, 1999Assignee: Zars, Inc.Inventors: Jie Zhang, Hao Zhang
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Patent number: 5916583Abstract: The present invention relates to an injectable solution for administration of one or more active compounds. According to the invention the active compound, which is in its neutral form, is dissolved in a biologically acceptable solvent whereby the active compound by administration precipitates, forming a solid phase of the solution in situ. Thus, said solution, which is easy to sterilize, is acting like a suspension when injected.Type: GrantFiled: November 21, 1995Date of Patent: June 29, 1999Assignee: Astra AktiebolagInventors: Fredrik Broberg, Arne Brodin, Lisbet Rydhag, Sylvan G. Frank
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Patent number: 5912271Abstract: A new pharmaceutical preparation comprising one or more local anaesthetic agents, a polar lipid, a triacylglycerol and optionally water. The new pharmaceutical preparation is excellent for topical treatment of pain.Type: GrantFiled: September 18, 1995Date of Patent: June 15, 1999Assignee: Astra ABInventors: Arne Brodin, Anders Carlsson, Bengt Herslof, Martin Nicklasson, Lisbeth Rydhag
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Patent number: 5912018Abstract: The present invention provides an epidermal gel secretion of Arabian Gulf catfish which is useful in enhancing wound healing, alleviating muscle spasms and pain, and treating dermatological disorders.Type: GrantFiled: August 5, 1997Date of Patent: June 15, 1999Inventor: Jassim M. Al-Hassan
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Patent number: 5910512Abstract: A water-based topical analgesic and method of application wherein the analgesic contains capsicum, capsicum oleoresin and/or capsaicin. This analgesic is applied to the skin to provide relief for rheumatoid arthritis, osteoarthritis, and the like.Type: GrantFiled: August 2, 1996Date of Patent: June 8, 1999Assignee: Healthline Laboratories, Inc.Inventor: Dale Conant
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Patent number: 5908846Abstract: Topical composition for transdermal delivery of morphine. The composition contains certain morphine esters in association with a carrier. The compositions relieved pain or tranquilize a mammal when delivered transdermally.Type: GrantFiled: August 17, 1993Date of Patent: June 1, 1999Assignee: Pharmacia & Upjohn ABInventors: Hans Bundgaard, deceased, Lona Christrup, Jorn Drustrup, Ann Fullerton, Martin Nicklasson
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Patent number: 5885597Abstract: Disclosed is a topical composition for relieving pain in a person in need of such relief, consisting essentially of an effective amount of a combination of at least one corticoid analgesic, at least one arylpropionic acid type analgesic, and at least one p-aminobenzoic acid ester type local anesthetic; an amount effective in enhancing the effectiveness in relieving pain of the combination of capsaicin, and an amount effective to increase the transmission thereof of through the skin of at least one phospholipid and at least one polyoxyethylenepolyoxypropylene copolymer.Type: GrantFiled: October 1, 1997Date of Patent: March 23, 1999Assignee: Medical Research Industries,Inc.Inventors: Jonah Botknecht, Robert Fishman
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Patent number: 5882663Abstract: A method for providing pain relief includes topically applying to skin tissue an effective amount of higher homologs of isoparaffins, ranging from about C.sub.12 to C.sub.18. Compositions of the present invention include, with the isoparaffins in a mixture, at least one from the group consisting of salicylate, capsaicin, camphor, and menthol. Other constituents may be added for form creams or lotions.Type: GrantFiled: June 2, 1997Date of Patent: March 16, 1999Inventors: Erich A. Koeniger, Drahoslay Lim
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Patent number: 5858331Abstract: Prilocaine base, in liquid and micro rod crystal form, can be solubilized within hydrofluorocarbon propellants to produce a stable, oily liquid. The prilocaine base can be used to solubilize additional medicaments within hydrofluorocarbon propellants that are not ordinarily soluble. The combination of prilocaine base and hydrofluorocarbon propellant can be used as an aerosolized spray to provide topical anesthesia.Type: GrantFiled: December 30, 1996Date of Patent: January 12, 1999Inventor: Richard A. Henry
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Patent number: 5856342Abstract: New combination of a .beta.-receptor blocker, an enantiomer thereof, and a local anesthetic, administered simultaneously or sequentially, giving excellent pain relief. Also comprised in the invention is the use of a non-selective .beta.-receptor blocker alone, especially a non-selective .beta.-receptor blocker giving pain relief.Type: GrantFiled: April 28, 1995Date of Patent: January 5, 1999Assignee: Astra ABInventor: Arne Eek
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Patent number: 5853768Abstract: A topical preparation is provided for pain relief in humans, particularly joint pain, wherein methyl glucose, iodide salts, camphor and menthol are provided together wherein the pain relief features are enhanced by the amphoteric characteristics of the methyl glucose and iodide salts enhance penetration of the pain relief components of the composition.Type: GrantFiled: March 4, 1997Date of Patent: December 29, 1998Inventor: James Altadonna
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Patent number: 5827529Abstract: An external preparation for application to the skin containing lidocaine which comprises a drug-retaining layer placed on a support, wherein said drug-retaining layer comprises an adhesive gel base and 1 to 10% by weight of lidocaine, said base comprising a water-soluble high molecular weight substance, water and a water-retaining agent, which can release the active lidocaine gradually and constantly so that lidocaine is transdermally absorbed for a long period of time.Type: GrantFiled: June 10, 1994Date of Patent: October 27, 1998Assignee: Teikoku Seiyaku Kabushiki KaishaInventors: Masahiro Ono, Mitsuji Akazawa, Michiko Seki, Kiyomi Iwamoto, Ryoji Konishi
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Patent number: 5827823Abstract: Infusions of brain-derived neurotrophic factor, neurotrophin-3 or neurotrophin-4 are used to produce analgesia in mammals. In addition, these neurotrophins are used to treat other diseases or disorders mediated by serotonin.Type: GrantFiled: January 25, 1995Date of Patent: October 27, 1998Assignee: Regeneron Pharmaceuticals, Inc.Inventors: Judith Siuciak, Charles A. Altar, Ronald M. Lindsay
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Patent number: 5776952Abstract: A composition for topical therapy for symptoms of back pain, muscle tension or myofascial pain or a combination thereof, which comprises a topical carrier system for intact skin of the back or outer synovial membranes or both, which comprises a therapeutic dose of a local anesthetic, and which applies the local anesthetic to a region of skin lying beneath the topical carrier system.Type: GrantFiled: July 17, 1996Date of Patent: July 7, 1998Assignee: American Pharmed Labs, Inc.Inventor: Rainer K. Liedtke
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Patent number: 5679325Abstract: The composition of the present invention combines the local anaesthetic lidocaine in free base form and the non-CFC aerosol propellant HFC-134a (1,1,1,2-tetrafluoroethane; CF.sub.3 CH.sub.2 F) or HFC-227 (1,1,1,2,3,3,3-Heptafluoropropane; (CF.sub.3 CHFCF.sub.3), or a combination thereof, thus incorporating previously-unattainable amounts of the lidocaine free base in solution in a non-CFC aerosol propellant. This particular form of relatively-concentrated cosolvent-free anaesthetic permits improved inhalation delivery to the airway and lung, and topical airway local anaesthesia is thus readily provided. A method in accordance with the invention provides for release of the anaesthetic in aerosolized form of selected dosage from a canister containing the pressurized local anaesthetic composition into a patient's respiratory system directly or by way of an airway.Type: GrantFiled: September 19, 1996Date of Patent: October 21, 1997Inventor: Richard A. Henry
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Patent number: 5676955Abstract: This invention relates to a mixture of homologous narrow range lauryl polyglycol ethers, to its use as a local anaesthetic agent.Type: GrantFiled: June 6, 1995Date of Patent: October 14, 1997Assignee: Henkel Kommanditgesellschaft auf AktienInventors: Achim Ansmann, Ansgar Behler, Rolf Franke, Peter Schmersahl
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Patent number: 5667773Abstract: Topical anti-hyperalgesic film-forming compositions and methods of using compositions for the treatment of peripheral hyperalgesia comprising:a) a compound of the formula ##STR1## wherein M is ##STR2## wherein: R, R.sup.2, R.sup.3, R.sup.4, R.sup.7, Ar.sup.1 and Ar.sup.2 are as defined in the specification;b) a film-forming polymeric material containing the hyperalgesic compound; andc) an aqueous pharmaceutically acceptable carrier.Type: GrantFiled: March 12, 1996Date of Patent: September 16, 1997Assignee: Adolor CorporationInventors: John J. Farrar, Alan L. Maycock, Virendra Kumar, Imre (Jim) Balogh