Caries Patents (Class 514/835)
  • Patent number: 4992420
    Abstract: Kappa-caseino-glycopeptide compounds and desialylated derivatives thereof and compositions containing the same are employed for treating bacteria in the buccal cavity which are responsible for the formation of dental plaque and caries.
    Type: Grant
    Filed: July 17, 1990
    Date of Patent: February 12, 1991
    Assignee: Nestec S.A.
    Inventor: Jean-Richard Neeser
  • Patent number: 4990500
    Abstract: Oxirane-pseudooligosaccharides of the formula I ##STR1## in which z is zero or 1, their physiologically acceptable salts with acids, a process for their preparation, pharmaceutical preparations, and their use are described. The compounds have an .alpha.-glucosidase-inhibiting action.
    Type: Grant
    Filed: August 11, 1987
    Date of Patent: February 5, 1991
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Laszlo Vertesy, Joachim Betz, Hans-Wolfram Fehlhaber, Karl Geisen
  • Patent number: 4980151
    Abstract: An anticariogenic or antiperiodontitic agent containing, as an active component, yeast cells and/or water-soluble extracts of yeasts having antibacterial activity against Streptococcus mutans or Bacteroides gingivalis. This anticariogenic or antiperiodontitic agent has strong inhibitory effects on the growth of Streptococcus mutans causing dental caries and Bacteroids gingivalis causing periodontitis and has neither influence on intestinal microflora nor any side-effects when orally administered.
    Type: Grant
    Filed: November 22, 1989
    Date of Patent: December 25, 1990
    Assignee: Kabushiki Kaisha Advance Kaihatsu Kenkyujo
    Inventors: Yasuo Kawai, Kazuoki Ishihara
  • Patent number: 4978522
    Abstract: Oral compositions effective against caries containing strontium EDTA and a soluble fluoride ion source are described herein.
    Type: Grant
    Filed: March 9, 1989
    Date of Patent: December 18, 1990
    Assignee: The Procter & Gamble Company
    Inventors: Melvin A. Barbera, Francis O. Agricola, Robert V. Faller, Worth D. Bowman
  • Patent number: 4976954
    Abstract: Improved anticariogenic oral preparations having a pH of about 2.5 to about 5.0 comprise an anticariogenically effective amount of a water-soluble aluminum salt in a surfactant-containing emulsion system suitable for use in the mouth.
    Type: Grant
    Filed: November 23, 1987
    Date of Patent: December 11, 1990
    Assignee: Purdue Research Foundation
    Inventors: Carl J. Kleber, Mark S. Putt
  • Patent number: 4912089
    Abstract: The decomposition of sugar and production of glucan by Streptococcus mutans which causes dental caries are prevented by a purified Gymnemic acid as a cariostatic material derived from Gymnema sylvestre. The Gymnema sylvestre itself is used as a cariostatic food.
    Type: Grant
    Filed: November 6, 1987
    Date of Patent: March 27, 1990
    Inventor: Yasutake Hiji
  • Patent number: 4859656
    Abstract: The invention relates to a method of controlling microorganisms adhered to surfaces in biological material, by administering substances which alter the water-structure binding capacity of surfaces and phase-boundaries.To remove micro-organisms from the surfaces, organic and inorganic salts are used in combination with organic polymers, preferably biopolymers, with positively and/or negatively charged groups such as amino groups and carboxyl groups.The invention also relates to compositions and preparations for performing the method, e.g. ointments, pastes and washing liquids containing the above-mentioned substances, as well as toothpaste containing one or more organic or inorganic salts together with the above-mentioned polymers.
    Type: Grant
    Filed: September 10, 1986
    Date of Patent: August 22, 1989
    Assignee: Chemical Dynamics Sweden AB
    Inventors: Staffan Kjelleberg, Peter Ronnow
  • Patent number: 4828821
    Abstract: An inhibition of calcium salt crystal is obtained by application of acidic glycoprotein to areas to be protected from deposits or accumulations of unwanted calcium salt crystal. The acidic glycoprotein is a potent inhibitor of calculus in the body.
    Type: Grant
    Filed: August 22, 1986
    Date of Patent: May 9, 1989
    Assignee: Collaborative Research, Inc.
    Inventor: Paul R. Kelley
  • Patent number: 4820507
    Abstract: Oral and dental hygiene preparations containing quaternary ammonium compounds of the formula ##STR1## wherein R.sup.1 is an n-alkyl group, preferably containing from 8 to 12 carbon atoms, R.sup.2 is hydrogen, a CH.sub.3 -group or a CH.sub.2 OH-group and R.sup.3 is a CH.sub.3 -group or a group of the formula --CH.sub.2 --CH(OH)--R.sup.2, A is an inorganic or organic acid anion and n is the basicity of the anion. The quaternary ammonium compounds of formula I can have a plaque inhibiting effect and show only slight antimicrobial activity. R.sup.1 is preferably an n-decyl group, R.sup.2 is hydrogen and R.sup.3 is a CH.sub.3 -group or a 2-hydroxyethyl group. The oral and dent al hygiene preparations also preferably contain fluorides and/or organophosphonates as the anion A.
    Type: Grant
    Filed: March 2, 1987
    Date of Patent: April 11, 1989
    Assignee: Henkel Kommanditgesellschaft auf Aktien
    Inventors: Hans-Juergen Klueppel, Walter Ploeger, Horst Rutzen, Rudolf Lehmann
  • Patent number: 4774077
    Abstract: A chemically and physically stable antiplaque dentifrice comprising an antiplaque quaternary ammonium compound, a betaine surfactant, a humectant system of glycerin and/or sorbitol and a nonionic gelling agent, prepared by a process which comprises the preparation of two separate gel phases, an oil gel phase and a water gel phase, combining said gel phases into a single gel, and adding a dental abrasive thereto as the final step, or adding said abrasive to the water gel phase prior to the addition of the oil gel phase.
    Type: Grant
    Filed: October 1, 1987
    Date of Patent: September 27, 1988
    Assignee: Colgate-Palmolive Company
    Inventors: Robert J. Ferlauto, Jr., Kathleen M. Yuhasz
  • Patent number: 4774078
    Abstract: A cosmetically and therapeutically stable antiplaque dentifrice comprising a combination of hexetidine, a soluble zinc salt and a fluoride compound capable of providing a fluoride ion, as the antiplaque agent in dental vehicle containing a polyethylene glycol humectant and a dental abrasive.
    Type: Grant
    Filed: October 6, 1986
    Date of Patent: September 27, 1988
    Assignee: Colgate-Palmolive Company
    Inventors: John P. Curtis, Shamsul K. Bakar, John J. Donohue, Richard J. Crawford, Kathleen M. Yuhasz-Kotarsky, John M. Coviello, Jr.
  • Patent number: 4737359
    Abstract: Plaque is inhibited and oral hygiene promoted including reduction in caries formation by dispersing emulsan in water and contacting the aqueous dispersion with dental surfaces. Emulsan may be dispersed in dental preparation toothpaste or mouthwash.
    Type: Grant
    Filed: September 8, 1986
    Date of Patent: April 12, 1988
    Assignee: Colgate-Palmolive Company
    Inventors: Edward Eigen, Alexander J. Simone
  • Patent number: 4707361
    Abstract: A granular anhydrous dicalcium phosphate having a particle of a size sufficient for direct compression tablets and a surface area of greater than 5 meters.sup.2 /gram can be direct compression tableted. This product can be prepared by dehydrating granules of dicalcium phosphate dihydrate of a particle size sufficient for direct compression tableting and sufficiently large to allow the dehydration of the granules without lumping and without fracturing a majority of the granules. The granules are heated at a temperature sufficient to form anhydrous dicalcium phosphate. The product is a granular anhydrous dicalcium phosphate exhibiting good compressibility, flowability and whiteness while being in an anhydrous state.
    Type: Grant
    Filed: August 2, 1985
    Date of Patent: November 17, 1987
    Assignee: Stauffer Chemical Company
    Inventors: Carl G. Gustafson, Carolyn A. Ertell
  • Patent number: 4701318
    Abstract: A chemically and physically stable antiplaque dentifrice comprising an antiplaque quaternary ammonium compound, a betaine surfactant, a humectant system of gylcerin and/or sorbitol and a nonionic gelling agent, prepared by a process which comprises the preparation of two separate gel phases, an oil gel phase and a water gel phase, combining said gel phases into a single gel, and adding a dental abrasive thereto as the final step, or adding said abrasive to the water gel phase prior to the addition of the oil gel phase.
    Type: Grant
    Filed: April 25, 1986
    Date of Patent: October 20, 1987
    Assignee: Colgate-Palmolive Company
    Inventors: Robert J. Ferlauto, Jr., Kathleen M. Yuhasz
  • Patent number: 4693888
    Abstract: A caries-preventive composition comprises an antibody obtained by immunizing a mammal with at least one antigen selected from the group consisting of Streptococcus mutans, its cell-wall fraction, fibrous substance fraction, glucosyltransferase fraction and protein antigen fraction, and a synergist selected from the group consisting of fluorine compounds, chlorhexidine and its salts, lytic enzymes, bacteriocins, glucosyltransferase inhibitors, proteases and dextranases.
    Type: Grant
    Filed: August 7, 1984
    Date of Patent: September 15, 1987
    Assignee: Lion Corporation
    Inventors: Tsuneo Miyahara, Yoshihiro Harada, Katsuyuki Futakami, Yasukuni Nishida, Ryoko Konishi
  • Patent number: 4690776
    Abstract: A method of preparing a toothpaste composition by the steps of adding calcium phosphate in an amount of 0.5 to 5% by weight of the composition and sodium perborate in an amount of 0.5 to 5% by weight of the composition to hot water to form a first mixture and agitating the first mixture, adding to the first mixture sorbitol in an amount of 1 to 50% by weight of the composition, cornstarch in an amount of 0.5 to 10% by weight of the composition and aluminum hydroxide in an amount of 0.01 to 1% by weight of the composition to form a second mixture and agitating the second mixture, adding to the second mixture dicalcium phosphate in an amount of 1 to 50% by weight of the composition and sodium monofluoride phosphate in an amount of 0.7 to 0.8% by weight of the composition to form a third mixture and agitating the third mixture, adding to the third mixture sodium bicarbonate, in an amount of 1 to 50% by weight of the composition, gradually adding increments of a flavoring material in an amount of 0.
    Type: Grant
    Filed: January 8, 1986
    Date of Patent: September 1, 1987
    Inventor: Irwin E. Smigel
  • Patent number: 4687663
    Abstract: Disclosed is a method for cleaning teeth including extruding a first semi-solid component including hydrogen peroxide as an active ingredient, and extruding a second semi-solid component comprising sodium bicarbonate as an active ingredient, the first and second components being suitable for oral use. The first component and the second component are placed in contact with each other on a toothbrush. The teeth are brushed using the first and second components concurrently as a cleaning medium.
    Type: Grant
    Filed: June 17, 1985
    Date of Patent: August 18, 1987
    Inventor: Hans A. Schaeffer
  • Patent number: 4675188
    Abstract: A granular directly compressible anhydrous dicalcium phosphate having a particle size sufficient for efficient direct compression tableting, preferably at least 90 percent greater than 44 microns, a dentin abrasion value of less than 150 and a surface area of greater than 5 meters.sup.2 /gram can be prepared by dehydrating particles of soft dicalcium phosphate dihydrate of a particle size insufficient for direct compression tableting, preferably at least 10 percent less than about 44 microns such as by heating at a temperature sufficient to form anhydrous dicalcium phosphate. The dehydrated particles are then granulated with a binder. The product is a granular anhydrous dicalcium phosphate exhibiting good compressibility and flowability while being in an anhydrous state.
    Type: Grant
    Filed: August 2, 1985
    Date of Patent: June 23, 1987
    Assignee: Stauffer Chemical Company
    Inventor: Chihang R. Chu
  • Patent number: 4661342
    Abstract: There is provided an oral composition containing a hydroxamic acid represented by the formula R--CH.sub.2 --CO--NHOH (where R is an alkyl group or alkoxyphenyl group) or a salt thereof such as 2-(4-butoxyphenyl)acetohydroxamic acid, 2-(4-methoxyphenyl)acetohydroxamic acid, caprylohydroxamic acid, or laurohydroxamic acid. The oral composition prevents Streptococcus mutans from colonizing in the oral cavity and is effective in preventing dental caries and also in preventing and remedying periodontal disease.
    Type: Grant
    Filed: November 20, 1985
    Date of Patent: April 28, 1987
    Assignee: Lion Corporation
    Inventors: Yoji Yamazaki, Toshiyuki Okada, Tsuneo Miyahara
  • Patent number: 4647452
    Abstract: A composition and method for retarding plaque are disclosed. The composition comprises a mixture of a zinc salt with a non-ring halogenated aromatic salicylamide of a specified structure.
    Type: Grant
    Filed: November 8, 1985
    Date of Patent: March 3, 1987
    Assignee: Lever Brothers Company
    Inventors: Thomas W. Ritchey, Erwin Sharpe
  • Patent number: 4632917
    Abstract: Pseudooligosaccharides of the formula I ##STR1## in which l, m and n have the meanings given, physiologically acceptable salts thereof with acids, a process for their preparation, pharmaceutical products and their use are described. The compounds have an .alpha.-glucosidase-inhibiting action.
    Type: Grant
    Filed: September 3, 1985
    Date of Patent: December 30, 1986
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Laszlo Vertesy, Rudolf Bender, Hans-Wolfram Fehlhaber, Karl Geisen
  • Patent number: 4618602
    Abstract: Pseudooligosaccharide of the formula I ##STR1## and physiologically acceptable salts thereof with acids, a process for the preparation, pharmaceutical products and the use are described. The compound has a .alpha.-glucosidase-inhibiting action.
    Type: Grant
    Filed: September 3, 1985
    Date of Patent: October 21, 1986
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Laszlo Vertesy, Rudolf Bender, Hans-Wolfram Fehlhaber
  • Patent number: 4612190
    Abstract: A growth inhibitor for cariogenic bacteria which comprises containing therein dihydroguaiaretic acid as an active ingredient. In particular, the effect of growth inhibition to Streptococcus mutans RIMD 3125001 strain can be obtained at a concentration of 1/50,000.
    Type: Grant
    Filed: November 15, 1984
    Date of Patent: September 16, 1986
    Assignee: Takasago Perfumery Co., Ltd.
    Inventors: Toshiya Sato, Kenichi Asano, Yuzo Yamaguchi
  • Patent number: 4606911
    Abstract: A pharmaceutical composition for the prevention of dental caries which comprises as essential component(s) one or more of pentacyclic acid triterpenes of the formula: ##STR1## wherein R.sub.1 represents CH.sub.3, CHO or CH.sub.2 OH, R.sub.2 and R.sub.3 independently represent CH.sub.3 or COOH, R.sub.4 represents H, CH.sub.3, COOH or COOCH.sub.3, R.sub.5 and R.sub.6 independently represent H, CH.sub.3 or OH, and A represents two Hs or O, and their salts.
    Type: Grant
    Filed: July 15, 1985
    Date of Patent: August 19, 1986
    Assignee: Rohto Pharmaceutical Co. Ltd.
    Inventors: Shin'ichi Hayashi, Akiyoshi Yoshida, Shigeru Kametaka, Tetsuo Koike
  • Patent number: 4594242
    Abstract: A dentifrice composition comprising calcium hydrogenphosphate anhydride whose crystallite has an average size of 300 to 3,500 angstroms as measured by X-ray diffractometry and an aluminum oxide having an average particle size of 0.5 to 10 .mu.m is disclosed. The composition have an excellent cleaning ability and mild abrading property not causing damage of tooth enamel and gives good luster to teeth.
    Type: Grant
    Filed: January 9, 1985
    Date of Patent: June 10, 1986
    Assignee: Lion Corporation
    Inventors: Takeshi Naganuma, Natsumi Miyagawa, Toshiyuki Ozawa, Kazutoshi Tamura
  • Patent number: 4590215
    Abstract: A growth inhibitor for cariogenic bacteria which comprises containing therein l-.alpha.-cadinol as an active ingredient. In particular, the effect of growth inhibition to Streptococcus mutans IPCR 1009 strain can be produced at a concentration of 1/50,000.
    Type: Grant
    Filed: June 20, 1984
    Date of Patent: May 20, 1986
    Assignee: Takasago Perfumery Co., Ltd.
    Inventors: Yuzo Yamaguchi, Toshiya Sato
  • Patent number: 4557754
    Abstract: A novel compound bis-(N,N-dimethyl-N-carbodecyloxymethyl-N-ethyleneammonium)-sulphide dichloride of the formula ##STR1## A method for preparing said novel compound comprising quaternization of bis-(.beta.-dimethylaminoethyl)-sulphide with monochloroacetic acid decyl ester, molar ratio of said reagents being not more than 1:2.A chemotherapeutic antimicrobial preparation comprising said novel compound as an active principle in combination with a pharmaceutical carrier.A plant growth regulator in the form of an aqueous solution of said novel compound in a concentration of from 0.0001 to 0.1 wt. %.
    Type: Grant
    Filed: August 13, 1980
    Date of Patent: December 10, 1985
    Assignee: Institut Organicheskoi Khimii
    Inventors: Georgy A. Golik, Yaroslav P. Demchenko, Miron O. Lozinsky, Vladlen V. Malovik, Valery Y. Semeny
  • Patent number: 4515987
    Abstract: Described is a genus of compounds defined according to the structure: ##STR1## (Z) represents one of the moieties ##STR2## as well as the substantially pure compound defined according to the structure: ##STR3## and the use thereof for augmenting or enhancing the aroma or taste of consumable materials including foodstuffs, chewing gums, medicinal products, toothpastes, chewing tobaccos, smoking tobaccos, smoking tobacco articles, perfumes, colognes and perfumed articles including solid or liquid anionic, cationic, nonionic or zwitterionic detergents, fabric softeners, fabric softener articles, perfumed articles, hair preparations and the like.
    Type: Grant
    Filed: June 26, 1984
    Date of Patent: May 7, 1985
    Assignee: International Flavors & Fragrances Inc.
    Inventors: Richard M. Boden, Theodore J. Tyszkiewicz, Michael Licciardello, Manfred H. Vock, Joaquin F. Vinals, Patrick Whalen, Marie R. Hanna