Chemical Sterilizing Patents (Class 514/840)
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Patent number: 11717591Abstract: Contact lens treatment systems and methods for disinfecting contact lenses are described. These systems and methods utilize a coated catalytic disc, which contains a support disc and a manganese oxide present on at least a portion of the support disc. The coated catalytic disc contains 300 ?g to 1800 ?g of manganese, often in the form of manganese dioxide.Type: GrantFiled: November 29, 2018Date of Patent: August 8, 2023Assignee: Better Vision Solutions LLCInventor: Lynn Winterton
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Patent number: 8865776Abstract: The use of low molecular weight amino alcohols in ophthalmic compositions is described. These compounds have been found to enhance the efficacy of anti-microbial preservatives.Type: GrantFiled: September 18, 2013Date of Patent: October 21, 2014Assignee: Alcon Research, Ltd.Inventor: Bahram Asgharian
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Patent number: 8062607Abstract: The present invention provides a lens care kit for disinfecting and cleaning contact lenses. The lens care kit of the invention allows customers to visually identify when their lenses are disinfected, clean, and ready to wear. The invention is relied on color change to indicate the readiness of disinfection and cleaning of contact lenses.Type: GrantFiled: July 13, 2007Date of Patent: November 22, 2011Assignee: Novartis AGInventors: Jennifer Dawn Lane, Stephen Raymond Perreault, Elizabeth Hickson Beaullieu
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Patent number: 7837934Abstract: Packaging systems for storing ophthalmic devices such as contact lenses and to methods for packaging such ophthalmic devices with solutions to improve the comfort of the lenses during wear are disclosed. A packaging system includes an ophthalmic device stored in an aqueous packaging solution comprising a substantially water-soluble silicone-containing surfactant. Such solutions are retained on the surface of an unused lens for extended periods of time, resulting in surface modification that persists in the eye, which may provide significant improvement in the wetting properties of fresh contact lenses used for the first time and, moreover, even several hours after lens insertion, preventing dryness and improving lubricity.Type: GrantFiled: October 27, 2008Date of Patent: November 23, 2010Assignee: Bausch & Lomb IncorporatedInventors: Jeffrey G. Linhardt, Jay F. Kunzler
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Patent number: 7615523Abstract: The present invention relates to contact lens care product comprising dexpanthenol. The invention similarly relates to the usage of a contact lens care compositions of this kind for cleaning and optionally disinfecting contact lenses.Type: GrantFiled: October 6, 2006Date of Patent: November 10, 2009Assignee: Novartis AGInventors: Peter Schwind, Anton Scherer
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Patent number: 7560421Abstract: A method of disinfecting a contact lens is provided, including the steps of preparing a disinfecting liquid which contains hydrogen peroxide and at least one metal phthalocyanine compound dispersed or dissolved in an aqueous medium, immersing the contact lens in the disinfecting liquid, and irradiating the disinfecting liquid in which the contact lens is immersed with a light.Type: GrantFiled: August 14, 2003Date of Patent: July 14, 2009Assignee: Menicon Co., Ltd.Inventors: Kazuhiko Nakada, Kotaro Sakanishi
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Patent number: 7550418Abstract: An buffered aqueous contact lens disinfecting solution having much lower concentration of disinfecting agents, and less irritating to the eye. The solutions have a tonicity of 200 to 450 mOsm/kg, a pH of between 6 and 8, and a concentration of chloride ions below 1500 ppm. Despite having less than 1 ppm of antimicrobial, the solutions are effective against C. albicans within 15 minutes of contact.Type: GrantFiled: November 25, 2003Date of Patent: June 23, 2009Assignee: Novartis AGInventors: Fu-Pao Tsao, Karen Frances Lindley
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Patent number: 7488706Abstract: A multi-purpose contact lens care solution having high activity against fungi and certain bacteria comprising, in liquid aqueous medium, an alkylamine having the following formula, where R1 is a C13-17 alkyl, and R2 and R3 are each independently H or —CH3, and a non-ionic surfactant. The solution may optionally also include additional antimicrobial components, a buffer component, a viscosity inducing component, a surfactant, taurine, propylene glycol and/or a tonicity component. This solution additionally prevents losses in ocular tissue membrane integrity during contact lens wear.Type: GrantFiled: September 25, 2006Date of Patent: February 10, 2009Assignee: Advanced Medical Optics, Inc.Inventor: Zhi-Jian Yu
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Patent number: 7419944Abstract: Compositions effective as disinfecting solutions for ophthalmic devices such as contact lenses are provided. The compositions include a microbicide, preferably polyhexamethylene biguanide or alexidine, and a water soluble salt of a bis-aminopolyol, preferably 1,3-bis(tris[hydroxymethyl]methylamino)propane, as a buffering agent.Type: GrantFiled: November 29, 2001Date of Patent: September 2, 2008Assignee: Novartis AGInventors: Mary Mowrey-McKee, Marc Ajello
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Patent number: 7157412Abstract: A multi-purpose contact lens care solution having high activity against fungi and certain bacteria comprising, in liquid aqueous medium, an alkylamine having the following formula, where R1 is a C13-17 alkyl, and R2 and R3 are each independently H or —CH3, and a non-ionic surfactant. The solution may optionally also include additional antimicrobial components, a buffer component, a viscosity inducing component, a surfactant, taurine, propylene glycol and/or a tonicity component. This solution additionally prevents losses in ocular tissue membrane integrity during contact lens wear.Type: GrantFiled: April 7, 2004Date of Patent: January 2, 2007Assignee: Advanced Medical Optics, Inc.Inventor: Zhi-Jian Yu
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Patent number: 7135442Abstract: The present invention relates to contact lens care product comprising dexpanthenol. The invention similarly relates to the usage of a contact lens care compositions of this kind for cleaning and optionally disinfecting contact lenses.Type: GrantFiled: January 11, 2002Date of Patent: November 14, 2006Assignee: Novartis AGInventors: Peter Schwind, Anton Scherer
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Patent number: 7105473Abstract: Multi-purpose solutions for contact lens care provide substantial lens wearer/user comfort and/or acceptability, with minimal, if any, corneal epithelial punctate fluorescein staining. Such solutions may include an aqueous liquid medium; an antimicrobial component comprising polyquarternium-1 and a hexamethylene biguanide polymer having a number average molecular weight in the range of from about 4,000 to about 45,000; a surfactant component, preferably a poly(oxyethylene)-poly(oxypropylene) block copolymer surfactant, in an effective amount; a buffer component in an effective amount; a viscosity-inducing component, preferably selected from cellulosic derivatives, in an effective amount; and a tonicity component in an effective amount. Such solutions have substantial performance, comfort and acceptability benefits, which, ultimately, lead to ocular health advantages and avoidance of problems caused by contact lens wear.Type: GrantFiled: June 13, 2005Date of Patent: September 12, 2006Assignee: Advanced Medical Optics, Inc.Inventors: Robert Glick, Stanley W. Huth, Zhi-Jian Yu, Charles H. Powell
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Patent number: 7045095Abstract: The use of low molecular weight amino alcohols in ophthalmic compositions is described. These compounds have been found to enhance the efficacy of anti-microbial preservatives.Type: GrantFiled: June 28, 2005Date of Patent: May 16, 2006Assignee: Alcon Manufacturing, Ltd.Inventor: Bahram Asgharian
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Patent number: 7025958Abstract: The use of amidoamines to treat or prevent infections attributable to Acanthamoeba and fungi is described. The amidoamines are highly effective against both Acanthamoeba and fungi, and are less toxic to delicate tissues that may become infected with these types of microorganisms (e.g., the cornea).Type: GrantFiled: November 27, 2001Date of Patent: April 11, 2006Assignee: Alcon, Inc.Inventors: Ronald L. Schlitzer, Nissanke L. Dassanayake, Ruth Ann Rosenthal, Sally L. Buck
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Patent number: 7022654Abstract: A composition for disinfecting a contact lens comprising an effective disinfecting amount of hydrogen peroxide and a surfactant comprising a copolymer of hydrophobe and hydrophile blocks the structure: HO-(hydrophobe)x-(hydrophile)y-(hydrophobe)x-H or HO-(hydrophile)y-(hydrophobe)x-(hydrophile)y-H where x and y are integers reflecting the respective hydrophile and hydrophobe blocks of said copolymer; and the hydrophile component of the block copolymer constitutes less than 50 weight percent of the block copolymer. The block copolymer has a Ross-Miles foam height (ASTM designation D-1173-53; 0.1%, at 50° C.) of less than 1 mm.Type: GrantFiled: September 26, 2001Date of Patent: April 4, 2006Assignee: Novartis AGInventor: Fu-Pao Tsao
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Patent number: 6962693Abstract: Alkylpolypropyleneoxide amidotriamines having antimicrobial activity are described. The compounds are useful as antimicrobial preservatives in various types of pharmaceutical compositions. Ophthalmic compositions containing these compounds as disinfecting agents or preservatives are also described.Type: GrantFiled: November 30, 2004Date of Patent: November 8, 2005Assignee: Alcon, Inc.Inventors: Nissanke L. Dassanayake, Ronald L. Schlitzer
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Patent number: 6949218Abstract: The use of low molecular weight amino alcohols in ophthalmic compositions is described. These compounds have been found to enhance the efficacy of anti-microbial preservatives.Type: GrantFiled: October 22, 2001Date of Patent: September 27, 2005Assignee: Alcon Manufacturing, Ltd.Inventor: Bahram Asgharian
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Patent number: 6939511Abstract: A method and composition for disinfecting a contact lens is disclosed. The method includes treating a lens with an aqueous solution having reduced toxicity to the eye which contains an effective amount of a monoperphthalic acid compound in a concentration of less than about 0.5% by weight of the solution. The lens disinfecting solution is capable of disinfecting contact lenses without irritating the eye due to reduced toxicity of the composition.Type: GrantFiled: April 2, 2003Date of Patent: September 6, 2005Assignee: Novartis AGInventor: Fu-Pao Tsao
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Patent number: 6930077Abstract: Multi-purpose solutions for contact lens care provide substantial lens wearer/user comfort and/or acceptability, with minimal, if any, corneal epithelial punctate fluorescein staining. Such solutions may include an aqueous liquid medium; an antimicrobial component comprising polyquarternium-1 and a hexamethylene biguanide polymer having a number average molecular weight in the range of from about 4,000 to about 45,000; a surfactant component, preferably a poly(oxyethylene)-poly(oxypropylene) block copolymer surfactant, in an effective amount; a buffer component in an effective amount; a viscosity-inducing component, preferably selected from cellulosic derivatives, in an effective amount; and a tonicity component in an effective amount. Such solutions have substantial performance, comfort and acceptability benefits, which, ultimately, lead to ocular health advantages and avoidance of problems caused by contact lens wear.Type: GrantFiled: September 10, 2003Date of Patent: August 16, 2005Assignee: Advanced Medical Optics, Inc.Inventors: Robert Glick, Stanley W. Huth, Zhi-Jian Yu, Charles H. Powell
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Patent number: 6849253Abstract: Water-soluble borate-polyol complexes are useful as buffers and/or antimicrobials in aqueous ophthalmic compositions, including those containing polyvinyl alcohol. These compositions have greater antimicrobial activity than comparable compositions containing typical borate buffers and unexpectedly increase the antimicrobial efficacy of other antimicrobial agents when used in combination. In addition, use of the borate-polyol complexes avoids the incompatibility problem typically associated with the combination of borate buffer and polyvinyl alcohol; therefore, the compositions disclosed herein may also contain polyvinyl alcohol.Type: GrantFiled: November 22, 2002Date of Patent: February 1, 2005Assignee: Alcon Manufacturing, Ltd.Inventors: Masood Chowhan, Nissanke L. Dassanayake
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Patent number: 6793941Abstract: Benzyldimethyl{2-[2-(p-1,1,3,3-tetramethylbutylphenoxy)ethoxy]ethyl} ammonium chloride (BDT) forms the basis of contact lens solutions that are unusually effective at reducing the number and wide variety of pathogenic microorganisms that may infect rigid gas permeable or soft contact lenses. Furthermore, it has been discovered that natural occurring compounds alone and in combination with chemical agents can be used in ophthalmic solutions such as contact lens solution to enhance and complement their anti-microbial, cleaning and wetting activity or to reduce irritation to the eye. The basic contact lens solution comprises an effective concentration of BDT (preferably 1 to 100 parts per million), with naturally occurring plant products possessing activities complementary to BDT, in an isotonic diluent buffered with a physiologically acceptable buffer to a physiologically natural range.Type: GrantFiled: November 13, 2000Date of Patent: September 21, 2004Assignee: Natural Disinfectant Technologies, Inc.Inventors: Chris De Bruijn, F. Richard Christ, Anthony J. Dziabo, Joseph Vigh
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Publication number: 20040071591Abstract: A method and composition for disinfecting a contact lens is disclosed. The method includes treating a lens with an aqueous solution having reduced toxicity to the eye which contains an effective amount of a monoperphthalic acid compound in a concentration of less than about 0.5% by weight of the solution. The lens disinfecting solution is capable of disinfecting contact lenses without irritating the eye due to reduced toxicity of the composition.Type: ApplicationFiled: April 2, 2003Publication date: April 15, 2004Inventor: Fu-Pao Tsao
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Patent number: 6617291Abstract: The present invention relates to improved ophthalmic solutions that employ allantoin in order to more effectively preserve solutions and to reduce the degree to which cationic preservatives will deposit on contact lenses. Ophthalmic solutions are here understood to include contact lens treatment solutions, such as cleaners, soaking solutions, conditioning solutions and lens storage solutions, as well as wetting solutions and in-eye solutions for treatment of eye conditions.Type: GrantFiled: November 8, 2001Date of Patent: September 9, 2003Inventor: Francis X. Smith
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Patent number: 6569824Abstract: A method and composition for disinfecting a contact lens is disclosed. The method includes treating a lens with an aqueous solution having reduced toxicity to the eye which contains an effective amount of a monoperphthalic acid compound in a concentration of less than about 0.5% by weight of the solution. The lens disinfecting solution is capable of disinfecting contact lenses without irritating the eye due to reduced toxicity of the composition.Type: GrantFiled: February 7, 2001Date of Patent: May 27, 2003Assignee: Novartis AGInventor: Fu-Pao Tsao
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Patent number: 6528464Abstract: The invention provides a method for inhibiting the binding of a biguanide antimicrobial in aqueous solution to a hydrogel in contact with said solution comprising providing in said solution an amount of cyclodextrin sufficient to inhibit sorption of the biguanide antimicrobial to a hydrogel.Type: GrantFiled: August 17, 2001Date of Patent: March 4, 2003Assignee: Bausch & Lomb IncorporatedInventors: Erning Xia, Richard V. Smerbeck, Rebecca Franklin
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Patent number: 6503497Abstract: Water-soluble borate-polyol complexes are useful as buffers and/or antimicrobials in aqueous ophthalmic compositions, including those containing polyvinyl alcohol. These compositions have greater antimicrobial activity than comparable compositions containing typical borate buffers and unexpectedly increase the antimicrobial efficacy of other antimicrobial agents when used in combination. In addition, use of the boratepolyol complexes avoids the incompatibility problem typically associated with the combination of borate buffer and polyvinyl alcohol; therefore, the compositions disclosed herein may also contain polyvinyl alcohol.Type: GrantFiled: December 19, 2001Date of Patent: January 7, 2003Assignee: Alcon Manufacturing, Ltd.Inventors: Masood Chowhan, Nissanke L. Dassanayake
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Patent number: 6478881Abstract: The present invention is based on the unexpected finding that the combination of a carboxylate containing anionic polymer, of molecular weight greater than about 1000 daltons, with cleaning agents, provides improved contact lens cleaning preparations. The present invention includes contacting a soiled contact lens with an aqueous solution comprising an anionically charged polymer and a surfactant or surfactant combination selected from the classes of nonionic surfactants, anionic surfactants, and amphoteric surfactants.Type: GrantFiled: February 28, 2001Date of Patent: November 12, 2002Assignee: Vista Scientific L.L.C.Inventors: Jeanne Y. Ellis, Edward J. Ellis
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Publication number: 20020068013Abstract: Biomedical devices with antimicrobial coatings are provided. One or more surfaces of the device are coated with lactoferrin to impart antimicrobial properties to the surface.Type: ApplicationFiled: October 2, 1998Publication date: June 6, 2002Inventors: MARK WILCOX, TIMOTHY WILLIAMS, RENE SCHNEIDER, DOUGLAS VANDERLAAN
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Patent number: 6369112Abstract: The present invention is directed to a biguanide-containing disinfecting solution containing tyloxapol in combination with a poloxamine for stabilizing the biguanide, which is especially useful for contact-lens solutions that provide enhanced disinfecting and enhanced cleaning efficacy. The method of the present invention comprises cleaning and disinfecting a contact lens with the above-described solution.Type: GrantFiled: December 15, 1998Date of Patent: April 9, 2002Assignee: Bausch & Lomb IncorporatedInventor: Erning Xia
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Patent number: 6365636Abstract: Water-soluble borate-polyol complexes are useful as buffers and/or antimicrobials in aqueous ophthalmic compositions, including those containing polyvinyl alcohol. These compositions have greater antimicrobial activity than comparable compositions containing typical borate buffers and unexpectedly increase the antimicrobial efficacy of other antimicrobial agents when used in combination. In addition, use of the borate-polyol complexes avoids the incompatibility problem typically associated with the combination of borate buffer and polyvinyl alcohol; therefore, the compositions disclosed herein may also contain polyvinyl alcohol.Type: GrantFiled: June 20, 2000Date of Patent: April 2, 2002Assignee: Alcon Manufacturing, Ltd.Inventors: Masood Chowhan, Nissanke L. Dassanayake
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Patent number: 6323165Abstract: The invention is directed to compositions and methods used as in-the-eye and/or out-of-eye inhibitors of proteinaceous deposits on hydrophilic contact lenses. Compositions of the present invention comprise moderately charged polyquaternium polymers that selectively bind to hydrophilic contact lenses to block the binding of proteinaceous materials. Compositions of the present invention may be used in multipurpose cleaning solutions for contact lenses and can eliminate the need for special enzyme cleaners and the like for removing proteinaceous materials.Type: GrantFiled: April 25, 2000Date of Patent: November 27, 2001Assignee: Bausch & Lomb IncorporatedInventors: David J. Heiler, Stephen E. Maier, Susan P. Spooner
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Patent number: 6319464Abstract: The use of low molecular weight amino alcohols in ophthalmic boric solution is described herein. These compounds have been found to enhance the efficacy of antimicrobial preservatives. Particularly preferred amino alcohols are 2-amino-2-methyl-1-propanol (AMP), 2-dimethylamino-2-methyl-1-propanediol (DMAMP), 2-amino-2-ethylpropanol (AMP), 2-amino-2-methyl-1,3-propanediol (AMPD), and 2-amino-1-butanol (AB). The ophthalmic compositions further optionally comprise a borate/polyol buffer system and an alkylamine.Type: GrantFiled: May 14, 1999Date of Patent: November 20, 2001Assignee: Alcon Manufacturing, Ltd.Inventor: Bahram Asgharian
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Patent number: 6316669Abstract: Bis-amido polybiguanides and their use as antimicrobial agents in pharmaceutical compositions are disclosed. A method of synthesis of bis-amido polybiguanides is also disclosed. The bis-amido polybiguanides are useful in the preservation of pharmaceutical compositions, particularly ophthalmic and otic pharmaceutical compositions and compositions for treating contact lenses. The compounds are especially useful for disinfecting/cleaning contact lenses.Type: GrantFiled: September 19, 2000Date of Patent: November 13, 2001Assignee: Alcon Manufacturing, Ltd.Inventors: Joonsup Park, Nathaniel D. McQueen
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Patent number: 6258591Abstract: The present invention provides a combined formulation for disinfecting, neutralizing and cleaning a soft contact lens and a method using the same easily, efficiently and safely. The formulation is a one-solution type of combined formulation for disinfecting, neutralizing and cleaning a soft contact lens, which includes a first formulation that contains an iodine-based disinfectant and a proteolytic enzyme and a second formulation that contains a reducing and a foaming agent treated with a delayed release coating, and which contains a nonionic surfactant in at least one of the first and second formulations. A stained soft contact lens can be disinfected, neutralized and cleaned easily by holding it in an aqueous solution colored yellow or brown by iodine molecules and removing it from the aqueous solution after the solution becomes almost colorless.Type: GrantFiled: December 3, 1998Date of Patent: July 10, 2001Assignee: Ophtecs CorporationInventors: Toyoaki Yoneda, Takashi Fujii, Mika Morita, Takeshi Ohnuma, Hiroshi Tanouchi, Shigeru Nakamura
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Patent number: 6228333Abstract: An apparatus for the catalytic decomposition of H2O2 in an aqueous solution which is a contact lens care agent, wherein the catalyst is formed by a shaped body which is roughened by sand blasting and which is coated by a platinum layer 1 which is produced by sputtering.Type: GrantFiled: October 18, 1999Date of Patent: May 8, 2001Assignee: MDLE Medical Device Laboratories Europe GmbHInventor: Wolfgang G. K. Mueller-Lierheim
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Patent number: 6210639Abstract: Compositions and methods of disinfecting and cleaning medical articles are disclosed. Disinfecting contact lenses by generating of peracetic acid in situ, while simultaneously cleaning with a proteolytic enzyme, is a preferred embodiment. Tablets for simple consumer use including disinfecting and cleaning means, and delayed release neutralizing means, are also disclosed.Type: GrantFiled: October 26, 1998Date of Patent: April 3, 2001Assignee: Novartis AGInventors: Elizabeth Gayle Vlass, Christopher Roy Boam, Ian Michael Riorden George, Stephen Dennis Cooper
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Patent number: 6187264Abstract: A solution for preserving and/or disinfecting a contact lens characterized by containing polylysine.Type: GrantFiled: August 26, 1998Date of Patent: February 13, 2001Assignee: Asahi Kasei Kogyo Kabushiki KaishaInventors: Nobuyuki Osawa, Seiichiro Ikawa
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Patent number: 6165415Abstract: A system for disinfecting a contact lens includes a first container section holding a first liquid medium containing hydrogen peroxide. A second container section is provided and holds a second liquid medium containing a hydrogen peroxide destroying component. The first and second container sections are configured to substantially simultaneously provide the first liquid medium and the second liquid medium to form a combined liquid medium containing an amount of hydrogen peroxide from the first liquid medium effective to disinfect a contact lens contacted with the combined liquid medium and an amount of hydrogen peroxide destroying component from the second liquid medium effective to destroy at least a major amount of the hydrogen peroxide in the combined liquid medium.Type: GrantFiled: October 26, 1998Date of Patent: December 26, 2000Assignee: AllerganInventors: Terrence J. Hunt, Peter G. Bakhit
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Patent number: 6162835Abstract: Contact-lens disinfectant containing(a) magnesium monoperphthalate and(b) sodium cumenesulphonate,(c) sodium alkylbenzenesulphonate,(d) isotridecanol ethoxylate and(e) methylhydroxyethylcellulose,and packaging and a process for the preparation thereof.Type: GrantFiled: July 8, 1999Date of Patent: December 19, 2000Assignee: BODE Chemie GmbH & Co.Inventors: Axel Kramer, Peter Rudolph, Brigitte Meyer, Hanns Pietsch
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Patent number: 6162393Abstract: Benzyldimethyl {2-[2-(p-1,1,3,3-tetramethylbutylphenoxy)ethoxy]ethyl} ammonium chloride (BDT) forms the basis of contact lens solutions that are unusually effective at reducing the number and wide variety of pathogenic microorganisms that may infect rigid gas permeable or soft contact lenses. Furthermore, it has been discovered that natural occurring compounds alone and in combination with chemical agents can be used in ophthalmic solutions such as contact lens solution to enhance and complement their anti-microbial, cleaning and wetting activity or to reduce irritation to the eye. The basic contact lens solution comprises an effective concentration of BDT (preferably 1 to 100 parts per million), with naturally occurring plant products possessing activities complementary to BDT, in an isotonic diluent buffered with a physiologically acceptable buffer to a physiologically natural range.Type: GrantFiled: August 6, 1998Date of Patent: December 19, 2000Assignee: NDT, Inc.Inventors: Chris De Bruiju, F. Richard Christ, Anthony J. Dziabo, Joseph Vigh
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Patent number: 6143799Abstract: Water-soluble borate-polyol complexes are useful as buffers and/or antimicrobials in aqueous ophthalmic compositions, including those containing polyvinyl alcohol. These compositions have greater antimicrobial activity than comparable compositions containing typical borate buffers and unexpectedly increase the antimicrobial efficacy of other antimicrobial agents when used in combination. In addition, use of the borate-polyol complexes avoids the incompatibility problem typically associated with the combination of borate buffer and polyvinyl alcohol; therefore, the compositions disclosed herein may also contain polyvinyl alcohol.Type: GrantFiled: July 2, 1998Date of Patent: November 7, 2000Assignee: Alcon Laboratories, Inc.Inventors: Masood Chowhan, Nissanke L. Dassanayake
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Patent number: 6112900Abstract: A care kit for reducing irritation and other ocular problems associated with wearing contact lenses is disclosed. The care kit includes at least one solution for the care of contact lenses; at least one non-irritating solution for cleansing eyelids; instructions for informing contact lens wearers of the proper care of contacts in conjunction with eyelid hygiene for improved comfort while wearing contact lenses; and housing for securing the solution for the care of contact lenses, the solution for cleansing eyelids and the instructions. Preferably, the solution for the care of contact lenses can be selected from a group comprising contact lens cleansing solution, disinfecting solution, soaking solution, wetting solution, storage solution, rinsing solution or a combination thereof. The eyelid cleanser can be soaked into a disposable pad and wrapped within an impervious wrapper. Alternatively, the eyelid cleanser is enclosed within an impervious bottle.Type: GrantFiled: July 1, 1998Date of Patent: September 5, 2000Assignee: Ocusoft, Inc.Inventor: Nat G. Adkins, Jr.
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Patent number: 6093686Abstract: A liquid for contact lenses, containing a polymer (A) having a recurring unit represented by the formula (I): ##STR1## wherein n is 0 or 1. The liquid for contact lenses can considerably decrease variation of the base curve of a contact lens during preservation, and shows excellent antiseptic effect and excellent antibacterial effect.Type: GrantFiled: March 9, 1999Date of Patent: July 25, 2000Assignee: Menicon Co., Ltd.Inventors: Kazuhiko Nakada, Yutaka Matano
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Patent number: 6069120Abstract: Compositions containing a stable, liquid, ophthalmically acceptable enzyme and methods involving the combined use of these compositions with a polymeric antimicrobial agent are disclosed for the simultaneous cleaning and disinfecting of contact lens. Methods for a daily use regimen are also disclosed.Type: GrantFiled: December 18, 1996Date of Patent: May 30, 2000Assignee: Alcon Laboratories, Inc.Inventors: Bahram Asgharian, Bor-Shyue Hong
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Patent number: 6004510Abstract: The disclosure relates to a process for the treatment of a surface with a hygiene agent which can include the steps of: a) providing at the surface a non-photochemical catalyst (such as a transition metal compound) which catalyses the formation of the hygiene agent from one or more precursors, whereby the catalyst becomes deposited at the surface, and, b) subsequently treating the surface with a treatment agent (such as a solution of hydrogen peroxide) having the or each hygiene agent precursor, such that the hygiene agent is generated at the surface.Type: GrantFiled: August 5, 1997Date of Patent: December 21, 1999Assignee: Lever Brothers CompanyInventors: Peter Gilbert, Martin Vincent Jones
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Patent number: 5993833Abstract: The invention relates to the use of a histamine antagonist, an interleukin-1-antagonist and/or a TNF antagonist in a cosmetic, pharmaceutical or dermatological composition for treating sensitive skins. It relates especially to the use of a histamine antagonist, an interleukin-1 antagonist and/or a TNF alpha antagonist for preventing and/or combating skin irritations and/or sores and/or erythema and/or dysaesthetic sensations and/or sensations of inflammation and/or pruritus and/or prickling and/or tingling and/or discomfort and/or tightness of the skin and/or mucosae. It also relates to a composition containing a histamine antagonist, an interleukin-1 antagonist and/or a TNF alpha antagonist which limits or eliminates the irritant side-effects of certain products, and in particular of certain cosmetic, dermatological or pharmaceutical active agents.Type: GrantFiled: June 20, 1997Date of Patent: November 30, 1999Assignee: Societe L'Oreal S.A.Inventors: Olivier De Lacharriere, Lionel Breton, Catherine Cohen
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Patent number: 5965088Abstract: The present invention is directed to method of disinfecting a contact lens with an ophthalmically safe disinfecting aqueous solution comprising about 2.0 to about 8.0 ppm of a bis(biguanide) having the following formula: ##STR1## wherein R.sup.1 and R.sup.4 are independently selected from the group consisting of branched or unbranched alkyl having 4-12 carbon atoms, ether or thioether radical having 4-12 carbon atoms, or cycloalkyl or cycloalkyl-alky radical having 5-12 carbon atoms; R.sup.2 and R.sup.3 are independently selected from the group consisting of hydrogen, alkyl having 1-12 carbon atoms, alkoxyalkyl having 1-12 carbon atoms, or cycloalkyl or cycloalkyl-alkyl having 5-12, carbon atoms; R.sup.6 and R.sup.7 are independently selected from the group consisting of hydrogen and alkyl radical having 1-6 carbon atoms, and A in the above formula is selected from the group consisting of a divalent alkyl, alkyloxyalkyl, or alkylsufide radical each having 4-12 carbon atoms.Type: GrantFiled: October 23, 1997Date of Patent: October 12, 1999Inventors: Andrea M. Lever, O. William Lever, Jr.
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Patent number: 5925317Abstract: A method and system for disinfecting contact lenses with iodine using a neutralizing solution having a first, rapid neutralizing component which completes its reaction with available iodine in less than five seconds and a second, slower neutralizing component which completes its reaction with available iodine in about 3 to 30 minutes.Type: GrantFiled: December 6, 1996Date of Patent: July 20, 1999Assignee: Bausch & Lomb IncorporatedInventors: Jill S. Rogalskyj, David J. Heiler, Alyce K. Dobie
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Patent number: 5922279Abstract: The present invention provides methods for treating contact lenses and compositions for the same. The present invention includes contacting a lens with an aqueous solution comprising a pyrrolidone compound represented by the formula: ##STR1## wherein: R is a hydrogen or an alkyl group having from 1 to 6 carbon atoms. In preferred embodiments of the invention, the subject compounds are used in combination with antimicrobial agents for providing simultaneous disinfection and cleaning of contact lenses.Type: GrantFiled: February 6, 1997Date of Patent: July 13, 1999Assignee: Bausch & Lomb IncorporatedInventor: Susan P. Spooner
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Patent number: 5900213Abstract: N,N-dialkyl and N'-alkylethylene diamines of the formula: ##STR1## wherein R, R.sup.1 and R.sup.2 are as described in the specification. The compounds are useful in disinfecting and cleaning contact lenses and preserving ophthalmic products.Type: GrantFiled: March 25, 1998Date of Patent: May 4, 1999Assignee: Alcon Laboratories, Inc.Inventors: Nissanke L. Dassanayake, Ronald L. Schlitzer, Joonsup Park, Bahram Asgharian