Abstract: Composition and method for enhancing therapeutic effects of topically applied agents are disclosed. The cosmetic or therapeutic composition may include one or more of cosmetic or pharmaceutical agents present in a total amount of from 0.01 to 40 percent and one or more of hydroxycarboxylic acids or related compounds present in a total amount of from 0.01 to 99 percent by weight of the total composition. The cosmetic and pharmaceutical agents may include but not limited to age spots, wrinkles and keratoses removing agents; vitamins; aloes; sun screens; tanning, depigmenting and shampooing agents; antiyeasts; antifungal, antibacterial and antiviral agents; topical bronchial dilators and topical cardiovascular agents; hormonal agents; vasodilators; retinoids and other dermatological agents. The hydroxycarboxylic acids and related compounds include organic alpha and beta hydroxycarboxylic acids, alpha and beta ketocarboxylic acids and salts thereof.

Abstract: There is disclosed a method for treating skin along with a novel skin care composition comprising the following components in a suitable carrier:(a) from about 1 to about 10 weight percent of a cyclodextrin material; and(b) from about 1 to about 15 weight percent of an acid material selected from:alpha hydroxy acids, beta hydroxy acids, alpha keto acids, beta keto acids, and combinations thereof.The skin care composition includes a cyclodextrin material to reduce the irritation and stinging caused by the presence of the aforementioned acid materials.

Abstract: The use of substances that are generally recognized as safe for cosmetic or pharmaceutical applications and that have positive solution enthalpy, in particular sugar alcohols of general formula (I) where N=3, 4 and 5, preferably xylitol, in cosmetic or medicinal topical preparations is characterized in that the substances or substances in the preparations are present in a largely water-free medium and/or are shielded from an aqueous medium by a material barrier.

Abstract: A preparation for treating acne containing as active ingredients glycolic acid and tretinoin in an emollient base.

Abstract: Composition and method for enhancing therapeutic effects of topically applied agents are disclosed. The cosmetic or therapeutic composition may include one or more of cosmetic or pharmaceutical agents present in a total amount of from 0.01 to 40 percent and one or more of hydroxycarboxylic acids or related compounds present in a total amount of from 0.01 to 99 percent by weight of the total composition. The cosmetic and pharmaceutical agents may include but not limited to age spots, wrinkles and keratoses removing agents; vitamins; aloes; sun screens; tanning, depigmenting and shampooing agents; antiyeasts; antifungal, antibacterial and antiviral agents; topical bronchial dilators and topical cardiovascular agents; hormonal agents; vasodilators; retinoids and other dermatological agents. The hydroxycarboxylic acids and related compounds include organic alpha and beta hydroxycarboxylic acids, alpha and beta ketocarboxylic acids and salts thereof.

Abstract: The invention provides high purity alkoxytrimethylsilane fluids of the general formula ROSiMe.sub.3 wherein Me is methyl and R is a monovalent aliphatic hydrocarbon substituent which ranges from 14 to about 20 carbons, the fluid being substantially free of organic and inorganic contaminants, wherein the alkoxytrimethylsilanes are produced by a novel process, and can be readily incorporated into cosmetic formulations containing organic components without heating and provide improved sensory characteristics compared to those provided by the corresponding alcohols.

Abstract: This invention introduces a series of esters to be used as emollients in cosmetic formulations. These are C.sub.12 -C.sub.15 blended alcohol esters, C.sub.16, C.sub.18, C.sub.20 and C.sub.20 alcohol esters of fumaric and maleic acids.When used "neat" or in formulations they are unusually safe by standard cosmetic tests. A unique and ideal physical property of the C.sub.12 -C.sub.15 blend alcohol ester of fumaric acid is that it is a solid melting at body temperature.These esters, with their safety and physical properties, introduce the cosmetic chemist to new ideal cosmetic emollients for use in any cosmetic formulation.

Abstract: Uses of topical compositions comprising a 2-hydroxycarboxylic acid or related compound to alleviate or improve signs of skin, nail and hair changes associated with intrinsic or extrinsic aging are disclosed. 2-Hydroxycarboxylic acids and their related compounds include, for example, 2-hydroxyethanoic acid, 2-hydroxypropanoic acid, 2-methyl 2-hydroxypropanoic acid, 2-phenyl 2-hydroxyethanoic acid, 2-phenyl 2-methyl 2-hydroxyethanoic acid, 2-phenyl 3-hydroxypropanoic acid, 2,2-diphenyl 2-hydroxyethanoic acid, 2-hydroxybutane-1,4-dioic acid, 2,3-hihydroxybutane-1,4-dioic acid, 2-carboxy 2-hydroxypentane-1,5-dioic acid, 2-ketopropanoic acid, methyl 2-ketopropanoate, ethyl 2-ketopropanoate, and gluconolactone.

Abstract: A cosmetic emulsion is provided which includes water, an oily emollient and a thickening/compatibilizing agent which is a polyether. The polyether is formed from the reaction of a copolymer of ethylene oxide with a C.sub.3 -C.sub.4 alkylene oxide and a C.sub.12 -C.sub.40 alpha-olefin epoxide or glycidyl ether.

Abstract: A cosmetic composition is provided which includes a C.sub.2 -C.sub.4 alpha-hydroxycarboxylic acid and a C.sub.16 -C.sub.20 alpha-hydroxycarboxylic acid delivered in a pharmaceutically acceptable carrier. Most preferred as the longer chain acids is a mixture fractionated from lanolin. The cosmetic composition can be employed in a method for treating dermatological disorders, chronoaging and environmental abuse. Preferably the composition is intended to inhibit or reduce the formation of wrinkles and sagging of skin while improving glow and firmness.

Abstract: Hydroxylated milk glycerides having low levels of ethylenic unsaturation are disclosed. The hydroxylated milk glycerides can have enhanced resistance to rancidification and as such, are suitable for use in personal care compositions e.g., lotions, skin creams, lipsticks, eye shadow, and makeup. Personal care compositions comprising the hydroxylated milk glycerides can have enhanced properties as compared to personal care compositions which do not comprise the hydroxylated milk glycerides or alternatively comprise milk fat.

Abstract: Therapeutic treatment as well as prophylactic measures are provided by topical application of compositions containing an aryl 2-acetoxyethanoic acid to eradicate or prevent the development of axillary foul odor, foot malodor and other body odors, e.g. scalp, and skin, nail and follicular infections caused by microorganisms. The compositions are antimicrobial against several organisms that infect the skin and are specifically effective against P. acnes. The compositions are therapeutically effective against folliculitis and perifolliculitis and are useful for other skin lesions, nail and mucosal infections such as impetigo, seborrheic dermatitis, erythrasma and trichomycosis axillaris, associated with or caused by microorganisms. The therapeutic effect of the composition may be synergized or amplified by incorporating a cosmetic or dermatologic agent into the formulation for topical treatment of cosmetic and dermatologic indications.

Abstract: The invention relates to an oil-in-water type emulsion for moisturizing the upper layers of the epidermis, comprising a lipid phase dispersed in an aqueous phase. The lipid phase is composed of apolar plant products comprising from 5 to 15% by weight of plant oils and from 6 to 15% by weight of plant waxes. The aqueous phase comprises from 0.5 to 4% by weight of plant gums and from 2 to 7% by weight of polysaccharide-rich plant extracts. The percentages are expressed relative to the total weight of the emulsion. The composition of the preferred oil-in-water emulsion consists of 1 to 3% phosphatidylcholine, 0.5 to 2% guar gum, 0.5 to 2% carob gum, 0.5 to 2% aloe vera powder, 2 to 5% yucca powder, 15 to 40% glycerol, 5 to 10% balanites oil, 5 to 10% jojoba oil, 1 to 5% carnauba wax, and the balance essentially water.

Abstract: Disclosed herein is an external skin-care composition comprising hydroxycarboxylic acids or derivatives thereof represented by the general formulae (1), (2), and (3), or the salts thereof: ##STR1## wherein R.sup.1, R.sup.2, and R.sup.3 are each independently a hydroxyl group, an amino group or an alkoxyl group which may be substituted by 1-3 hydroxyl groups, l is a number of 7-11, m is a number of 6-10, and n is a number of 5-9. This composition exhibits an excellent moisturizing effect, moisturizes the skin, has a great effect in preventing skin roughness and shows excellent effects in enhancing the clear skin tone of the skin and reducing skin dullness, and is hence particularly useful for cosmetic skin-care compositions.

Abstract: Cosmetic formulations which are essentially free from saturated hydrocarbons and comprise(a) a lipid phase comprising at least one glycerol mono-, di- and/or tricarboxylic acid ester of branched and/or unbranched monobasic fatty acids having 18-36 carbon atoms (=mono-, di- and/or triglycerides) and at least one ester chosen from the group consisting of substances having the following structure ##STR1## (d) and furthermore, if appropriate, comprise water, further lipids, emulsifiers and customary further active compounds, auxiliaries and/or additives,and the use of such formulations for lip care.

Abstract: A waterproof water-in-oil emulsion, wherein the aqueous phase consists predominately of deionized water and the oil phase includes sunscreen active ingredients, silicone emulsifiers, oil soluble solubilizers and skin conditioning agents. The emulsion provides sun protection higher than SPF 30 and is characterized in that the mean particle size of the oil phase ingredients is 2.0 Microns (.mu.). The particles of the emulsion are uniformly distributed and substantially of the same size to reduce gaps between particles thus reducing the amount of skin left exposed to ultra violet radiation. A method of manufacturing the emulsion is also disclosed.

Abstract: The present invention is directed to a lubricating and/or germicidal composition, and a method of using the composition as an antiseptic for the hands or as a disinfectant for other inanimate objects, and/or for alleviating or preventing drying of skin. The composition is an alcoholic solution containing cetyl alcohol, glycolic acid, benzalkonium chloride, and a major amount of isopropyl alcohol. In a preferred use, the composition is applied to the surface of the hands as an antiseptic film or "invisible glove" beneath a surgical or other plastic glove to inhibit microbial growth and alleviate drying of the skin.

Abstract: An oil-in-water nanoemulsion in which the oil globules have a mean size of less than 100 nm and which contains an amphiphilic lipid component containing at least one non-ionic amphiphilic lipid which is liquid at an ambient temperature of less than 45.degree. C. The nanoemulsion can be used in the fields of cosmetics and dermopharmaceuticals. The nanoemulsion is stable on storage, can contain significant amounts of oil while retaining good transparency, and can contain heat-sensitive active agents.

Abstract: The present invention relates to non-abrasive personal care cleansing compositions. These compositions utilize insoluble micronized cleansing particles of defined particle size that are not tactilely perceived by the user during the cleansing process, and yet which provide improved cleansing performance from the composition. These compositions also comprise a surfactant, an emollient and water.

Abstract: Balanced emulsifier blends that provide a stable oil-in-water emulsion of preselected viscosity are disclosed. The emulsifier blend contains an acyl lactylate as the primary emulsifier and a nonionic surfactant as the coemulsifier. A method of preparing an oil-in-water emulsion having a preselected viscosity also is disclosed.

Abstract: The present invention relates to an amine derivative represented by the following general formula (I) or (II): ##STR1## wherein R.sup.1 means a heteroatom-containing C.sub.1 -C.sub.40 hydrocarbon group which may have a ring structure, or the like; R.sup.2 -R.sup.5 each denote a C.sub.1 -C.sub.20 hydrocarbon group, hydrogen or the like; A.sup.1 represents ##STR2## or R.sup.15 --Z--.sup.16 --(CH.sub.2).sub.n --; B.sup.1 stands for hydrogen, a C.sub.1 -C.sub.10 hydrocarbon group, nitrogen or the like; C.sup.1 denotes hydrogen, a C.sub.1 -C.sub.10 hydrocarbon group, nitrogen, alcohol residue, phosphoric acid residue or the like; a dermatologic preparation containing the same; and a process for producing the amine derivative. This amine derivative has excellent effects of smoothing or removing wrinkles and improving keratinization.

Abstract: The present invention relates to non-abrasive personal care cleansing compositions. These compositions utilize insoluble micronized cleansing particles of defined particle size that are not tactilely perceived by the user during the cleansing process, and yet which provide improved cleansing performance from the composition. These compositions also comprise a surfactant, an emollient and water.

Abstract: Methods for visibly reducing a skin wrinkle and for reversing the effect of aging on human facial skin involving comprising topically applying to the wrinkle and/or affected facial skin mucic acid or mucolactone.

Abstract: Composition and method for enhancing therapeutic effects of topically applied agents are disclosed. The cosmetic or therapeutic composition may include one or more of cosmetic or pharmaceutical agents present in a total amount of from 0.01 to 40 percent and one or more of hydroxycarboxylic acids or related compounds present in a total amount of from 0.01 to 99 percent by weight of the total composition. The cosmetic and pharmaceutical agents may include but not limited to age spots, wrinkles and keratoses removing agents; vitamins; aloes; sun screens; tanning, depigmenting and shampooing agents; antiyeasts; antifungal, antibacterial and antiviral agents; topical bronchial dilators and topical cardiovascular agents; hormonal agents; vasodilators; retinoids and other dermatological agents. The hydroxycarboxylic acids and related compounds include organic alpha and beta hydroxycarboxylic acids, alpha and beta ketocarboxylic acids and salts thereof.

Abstract: Alpha hydroxyacid esters and related compounds on topical application induced increased skin thickness due to new biosyntheses of dermal components including glycosaminoglycans, proteoglycans, collagen and elastin. Such dermal effects are desirable and beneficial for topical use and treatment of aging related integumental changes including age spots, skin lines, wrinkles, photoaging and aging skin.

Abstract: Methods for improved topical delivery of lactic acid comprising forming a topically acceptable composition by admixing lactic acid and an amphoteric or pseudoamphoteric agent, and applying said topically acceptable composition to the skin.

Abstract: A composition for external skin care comprising an amine derivative represented by the following formula (1), ##STR1## wherein R.sup.1 is a linear, branched, or cyclic saturated or unsaturated hydrocarbon group having 4-40 carbon atoms, and R.sup.2, R.sup.3, R.sup.4, R.sup.5, and R.sup.6 are individually a hydrogen atom or a hydrocarbon group having 1-10 carbon atoms, which may be substituted or unsubstituted by 1 or more hydroxy groups; or an acid addition salt thereof, in an amount from 0.0001 to less than 0.1% by weight; and a method of curing wrinkles and keratinization of the skin characterized by applying said amine derivative or its salt to the skin.

Abstract: Methods for improved topical delivery of an alpha hydroxyacid, alpha ketoacid or related compound.

Abstract: Methods for visibly reducing a skin wrinkle and for reversing the effect of aging on human facial skin involving comprising topically applying to the wrinkle and/or affected facial skin gluconic acid or gluconolactone.

Abstract: Methods for visibly reducing a skin wrinkle and for reversing the effect of aging on human facial skin involving comprising topically applying to the wrinkle and/or affected facial skin mandelic acid.

Abstract: Methods for visibly reducing a skin wrinkle and for reversing the effect of aging on human facial skin involving comprising topically applying to the wrinkle and/or affected facial skin lactic acid.

Abstract: Methods for visibly reducing a skin wrinkle and for reversing the effect of aging on human facial skin involving comprising topically applying to the wrinkle and/or affected facial skin citric acid.

Abstract: A method for reducing the itch and the scarring associated with chicken pox is disclosed. The method entails applying a topical pharmaceutical formulation of papain, pancreatin or subtilisin to the skin proximate to the vesicles. To further reduce scarring, an antibiotic is applied with the papain, pancreatin or subtilisin. Compositions are provided in the form of solutions, lotions, ointments and salves containing papain, pancreatin or subtilisin and, optionally, a surfactant, an antibiotic and a penetration enhancer.

Abstract: A method for visibly reducing a facial wrinkle by topically applying to the wrinkle gulonic acid or a topically effective salt thereof, or gulonolactone.

Abstract: Methods for visibly reducing a skin wrinkle and for reversing the effect of aging on human facial skin involving comprising topically applying to the wrinkle and/or affected facial skin pantoic acid or pantolactone.

Abstract: Methods for visibly reducing a skin wrinkle and for reversing the effect of aging on human facial skin involving comprising topically applying to the wrinkle and/or affected facial skin glucuronic acid or glucuronolactone.

Abstract: Composition and method for enhancing therapeutic effects of topically applied agents are disclosed. The cosmetic or therapeutic composition may include one or more of cosmetic or pharmaceutical agents present in a total amount of from 0.01 to 40 percent and one or more of hydroxycarboxylic acids or related compounds present in a total amount of from 0.01 to 99 percent by weight of the total composition. The cosmetic and pharmaceutical agents may include but not limited to age spots, wrinkles and keratoses removing agents; vitamins; aloes; sun screens; tanning, depigmenting and shampooing agents; antiyeasts; antifungal, antibacterial and antiviral agents; topical bronchial dilators and topical cardiovascular agents; hormonal agents; vasodilators; retinoids and other dermatological agents. The hydroxycarboxylic acids and related compounds include organic alpha and beta hydroxycarboxylic acids, alpha and beta ketocarboxylic acids and salts thereof.

Abstract: Xylobiose-containing skin preparations for external use are disclosed. Skin preparations for external use into which xylobiose may be incorporated include cosmetics such as clear lotions, milky lotions, packs and lip treatments, drugs or quasidrugs such as ointments and cataplasms, hair-care products such as rinses and hair conditions, and detergents such as hair shampoos and body shampoos. Xylobiose is typically contained in an amount of 0.0001-20 wt %, preferably 0.1-10 wt %, of the total amount of the skin preparation on a dry solids basis. The incorporation of xylobiose is effective not only in preventing the occurrence of stickiness, color change and malodor in the skin preparations but also in providing enhanced moisture retention and reducing excessive roughness and dryness of the skin and hair.

Abstract: The present invention relates to nonabrasive thickened aqueous-based personal cleansing compositions. These compositions utilize insoluble micronized cleansing particles of defined particle size that are not tactilely perceived by the user during the cleansing process, and yet which provide improved cleansing performance from the composition.

Abstract: Methods for visibly reducing a skin wrinkle and for reversing the effect of aging on human facial skin involving comprising topically applying to the wrinkle and/or affected facial skin ribonic acid or ribonolactone.

Abstract: The present invention deals with the certain novel esters which are prepared by the reaction of an alpha methyl alcohol and a fatty acid. These materials are useful as conditioning agents for skin.

Abstract: Methods for visibly reducing a skin wrinkle and for reversing the effect of aging on human facial skin involving comprising topically applying to the wrinkle and/or affected facial skin quinic acid or quinolactone.

Abstract: Methods for visibly reducing a skin wrinkle and for reversing the effect of aging on human facial skin involving comprising topically applying to the wrinkle and/or affected facial skin glycolic acid.

Abstract: Methods for visibly reducing a skin wrinkle and for reversing the effect of aging on human facial skin involving comprising topically applying to the wrinkle and/or affected facial skin gulonic acid or gulonolactone.

Abstract: Methods for visibly reducing a skin wrinkle and for reversing the effect of aging on human facial skin involving comprising topically applying to the wrinkle and/or affected facial skin saccharic acid or saccharolactone.

Abstract: Methods for visibly reducing a skin wrinkle and for reversing the effect of aging on human facial skin involving comprising topically applying to the wrinkle and/or affected facial skin benzilic acid.

Abstract: Methods for visibly reducing a skin wrinkle and for reversing the effect of aging on human facial skin involving comprising topically applying to the wrinkle and/or affected facial skin citramalic acid.

Abstract: Methods for visibly reducing a skin wrinkle and for reversing the effect of aging on human facial skin involving comprising topically applying to the wrinkle and/or affected facial skin galactonic acid or galactonolactone.

Abstract: Methods for visibly reducing a skin wrinkle and for reversing the effect of aging on human facial skin involving comprising topically applying to the wrinkle and/or affected facial skin galacturonic acid or galacturonolactone.

Abstract: Methods for visibly reducing a skin wrinkle and for reversing the effect of aging on human facial skin involving comprising topically applying to the wrinkle and/or affected facial skin methyllactic acid.