Laxative Patents (Class 514/892)
  • Patent number: 5425945
    Abstract: Agglomerated psyllium husk comprising edible acid uniformly dispersed throughout the agglomerating coating. Preferred are maltodextrin-containing agglomerates of psyllium husk comprising citric acid uniformly dispersed throughout the maltodextrin coating. This agglomerated psyllium husk has improved mixability and dispersibility in liquids.
    Type: Grant
    Filed: March 14, 1994
    Date of Patent: June 20, 1995
    Assignee: The Procter & Gamble Company
    Inventor: Melvin A. Barbera
  • Patent number: 5418220
    Abstract: The invention disclosed relates to the use of dimethicone as an agent for treating constipation.
    Type: Grant
    Filed: March 8, 1994
    Date of Patent: May 23, 1995
    Inventors: Alfred Schmidt, Hans-Jurgen Upmeyer
  • Patent number: 5397573
    Abstract: Laxative compositions containing sennoside and menthol, pharmaceutically-acceptable esters of menthol, or mixtures thereof, preferably as peppermint oil; and methods for treating constipation by orally concurrently administering to the lower gastrointestinal tract of a person in need of such treatment sennoside and menthol.
    Type: Grant
    Filed: June 4, 1993
    Date of Patent: March 14, 1995
    Assignee: The Procter & Gamble Company
    Inventors: Theresa M. Kajs, Paul J. Sagel
  • Patent number: 5389372
    Abstract: A stable formulation of Sennosides with increased shelf-life and good solubility comprising a granulate containing Senna extract concentrate and, for each part by weight of Senna extract concentrate, 1 to 3 parts of weight of sucrose.
    Type: Grant
    Filed: November 10, 1993
    Date of Patent: February 14, 1995
    Assignee: ASTA Medica Aktiengesellschaft
    Inventors: Luigi deMaria, Claudio Lasciarrea, Pietro Micheli, Hein-Uwe Schmersahl
  • Patent number: 5380717
    Abstract: A food composite performing a function of large bowel regulation and comprising a refined product of pyrodextrin obtained as an active ingredient through a process of decomposing starch or starch hydrolyzate by heating in the presence of an acid or without acid.
    Type: Grant
    Filed: August 17, 1993
    Date of Patent: January 10, 1995
    Assignee: Matsutani Chemical Industries Co., Ltd.
    Inventors: Kazuhiro Ohkuma, Shigeru Wakabayashi, Mitsuko Satouchi
  • Patent number: 5364636
    Abstract: A drug for preventing the absorption of food materials dissolved during digestion, a drug for preventing obesity, a drug for treating hyperlipemia, a drug for treating diabetes mellitus, and a drug for preventing constipation, wherein the flocculant and other auxiliary additives at request, are coated with the aquatic enteric material.
    Type: Grant
    Filed: April 1, 1992
    Date of Patent: November 15, 1994
    Assignee: Hanabusa Patent Office
    Inventor: Shigeo Ochi
  • Patent number: 5340580
    Abstract: Agglomerated psyllium husk comprising edible acid uniformly dispersed throughout the agglomerating coating. Preferred are maltodextrin-containing agglomerates of psyllium husk comprising citric acid uniformly dispersed throughout the maltodextrin coating. This agglomerated psyllium husk has improved mixability and dispersibility in liquids.
    Type: Grant
    Filed: May 6, 1993
    Date of Patent: August 23, 1994
    Assignee: The Procter & Gamble Company
    Inventor: Melvin A. Barbera
  • Patent number: 5338549
    Abstract: Psyllium husk-containing powdered drink mix compositions comprising a free radical scavenging antioxidant material to reduce the incidence of vacuum generation in air tight containers and of off-odors.
    Type: Grant
    Filed: December 21, 1992
    Date of Patent: August 16, 1994
    Assignee: The Procter & Gamble Company
    Inventors: Lee A. Hord, Robert E. Barron
  • Patent number: 5320847
    Abstract: A high-fiber, consumable bulk fiber composition, which may be used as a laxative, comprises powdered psyllium husks agglomerated with a water soluble, low viscosity gum, preferably gum acacia, to form a dry, free-flowing, water dispersible dietary fiber combinate. To form the dietary fiber combinate, the powdered psyllium husks are mixed with an aqueous solution of the water soluble, low viscosity gum, preferably by fluid bed agglomeration, and dried. The composition is employed to treat constipation by ingesting an effective amount of the dietary fiber combinate dispersed in water.
    Type: Grant
    Filed: May 13, 1993
    Date of Patent: June 14, 1994
    Assignee: Valentine Enterprises, Inc.
    Inventors: William Valentine, William K. Valentine
  • Patent number: 5274001
    Abstract: The present invention relates to orthostatic lavage solutions or colon evacuants for cleansing the gastrointestinal tract, or for treatment of bowel diseases and/or disorders, containing an effective amount of ascorbic acid or a salt thereof.
    Type: Grant
    Filed: July 17, 1990
    Date of Patent: December 28, 1993
    Inventor: Thomas J. Borody
  • Patent number: 5266334
    Abstract: Water-dispersible sugar-free powdered, bulk laxative compositions containing cellulose ethers as the active agent are disclosed. These bulk laxative compositions form smooth, palatable dispersions in water which dispersions contain a therapeutically effective amount of the cellulose ether.
    Type: Grant
    Filed: July 29, 1992
    Date of Patent: November 30, 1993
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Deepak S. Phadke, Julie L. Collier
  • Patent number: 5260283
    Abstract: Wheat bran fiber is used to alter the enterohepatic recirculation of estrogens leading to an increased fecal excretion of estrogens together with a decrease in urinary excretion of estrogens. Increased lipid excretion is also found. Thus wheat bran fiber is useful to remove estrogen and lipid in mammals.
    Type: Grant
    Filed: May 19, 1992
    Date of Patent: November 9, 1993
    Assignee: American Health Foundation
    Inventors: Marcia E. Kendall, Leonard A. Cohen
  • Patent number: 5250301
    Abstract: A liquid internal medicine contains only an extract from stems of natural Stevia plants. The medicine is particularly effective for curing disorders of the digestive organs. The medicine contains a liquid obtained by fermenting a concentrate of an extract from Stevia stems, and is administered to patients as is or after dilution. As the medicine contains only the natural component, it is free of any side effects when applied to patients.
    Type: Grant
    Filed: January 28, 1992
    Date of Patent: October 5, 1993
    Assignees: Fumio Dozono, Naohiko Sato
    Inventor: Fumio Dozono
  • Patent number: 5248502
    Abstract: A method of reducing the allergenicity of psyllium seed husk. Psyllium seed husk is treated with a alkaline solution at a temperature and for a time sufficient to reduce the allergenicity of the psyllium seed husk.
    Type: Grant
    Filed: November 8, 1991
    Date of Patent: September 28, 1993
    Assignee: Kellogg Company
    Inventor: Louis I. Ndife
  • Patent number: 5234916
    Abstract: Psyllium husk-containing drink mix compositions comprising the divalent cation salt of strong inorganic acids selected from the group consisting of magnesium sulfate, calcium sulfate, calcium chloride, zinc sulfate, zinc chloride and mixtures thereof.
    Type: Grant
    Filed: June 12, 1992
    Date of Patent: August 10, 1993
    Assignee: The Proctor & Gamble Company
    Inventor: Lee A. Hord
  • Patent number: 5232698
    Abstract: Psyllium husk-containing drink mix compositions comprising small particle size psyllium husk and edible, water soluble salts. The edible, water soluble salts are present at a level sufficient to reduce the gellation rate of the psyllium husk when dispersed in an aqueous solution.
    Type: Grant
    Filed: June 12, 1992
    Date of Patent: August 3, 1993
    Assignee: The Proctor & Gamble Company
    Inventor: Lee A. Hord
  • Patent number: 5232699
    Abstract: The present invention relates to laxative compositions comprising psyllium and sennoside wherein sennoside is dispersed in a palatable food grade fat having a melting point within the range of from about 30.degree. C. to about 50.degree. C.
    Type: Grant
    Filed: June 19, 1992
    Date of Patent: August 3, 1993
    Assignee: The Proctor & Gamble Company
    Inventor: John A. Colliopoulos
  • Patent number: 5219573
    Abstract: The present invention relates to novel monosaccharide sweeteners which are capable of acting as laxatives when administered in dose-effective amounts. The present invention also contemplates monosaccharides with laxative properties which have a natural carbohydrate structure. More specifically, the present invention contemplates monosaccharide substances capable of producing laxative effects in humans and having the advantages of being only minimally absorbed from the intestine; and having osmotic laxative effects on the small bowel and colon. The present invention allows for improved laxative formulations with increased palatability and better dosing for all age groups. The present invention can be used to induce mild laxation six to ten hours after ingestion.
    Type: Grant
    Filed: October 17, 1989
    Date of Patent: June 15, 1993
    Assignee: Hershey Foods Corporation
    Inventors: Stanley M. Tarka, Jr., Carol A. Shively, Joan L. Apgar, Kenneth L. Koch
  • Patent number: 5219570
    Abstract: Agglomerated psyllium husk comprising edible acid uniformly dispersed throughout the agglomerating coating. Preferred are maltodextrin-containing agglomerates of psyllium husk comprising citric acid uniformly dispersed throughout the maltodextrin coating. This agglomerated psyllium husk has improved mixability and dispersilibity in liquids.
    Type: Grant
    Filed: March 25, 1992
    Date of Patent: June 15, 1993
    Assignee: The Procter & Gamble Company
    Inventor: Melvin A. Barbera
  • Patent number: 5206355
    Abstract: Sucrose is treated with an acid catalyst to form an amorphous sucrose anhydrous melt. Heating of the anhydrous melt at 80.degree.-100.degree. C. forms three known kestoses and the novel products, viz. .alpha.-fructosylsucrose anomers of 6-kestose, neokestose, and 1-kestose. Heating of the anhydrous melt at 125.degree.-175.degree. C. produces a fructoglucan sucrose polymer having a molecular weight of about 2,000 to 10,000 Daltons. All of these products are useful as sweeteners, food additives, additives for animal food, and bulking agents.
    Type: Grant
    Filed: March 19, 1992
    Date of Patent: April 27, 1993
    Assignee: The University of Montana
    Inventors: Geoffrey N. Richards, Merilyn Manley-Harris
  • Patent number: 5149541
    Abstract: Psyllium husk comprising particle sizes distributed such that: less than about 15% is larger than about 80 mesh, at least about 45% is within the range of from about 80 mesh to about 200 mesh, and less than about 40% is smaller than about 200 mesh. In addition, psyllium-containing products for oral administration comprising small particle size psyllium husk according to the present invention are described.
    Type: Grant
    Filed: February 20, 1991
    Date of Patent: September 22, 1992
    Assignee: The Procter & Gamble Company
    Inventors: Paul D. Leis, Jr., Larry E. Burns, Karen R. Hafer
  • Patent number: 5143728
    Abstract: Psyllium-containing filling compositions having excellent texture, mouthfeel, and palatability. These filling compositions essentially comprise psyllium fiber and higher levels of glycerin, and preferably comprise sweeteners and flavorants. Furthermore, they have water activities ("A.sub.W ") below about 0.35. The compositions are ingested to control constipation, bowel function, blood cholestrol levels, glood glucose tolerance, and/or appetite, as well as for prophylaxis and treatment of intestinal disorders.
    Type: Grant
    Filed: May 1, 1991
    Date of Patent: September 1, 1992
    Assignee: The Procter & Gamble Company
    Inventors: James W. Cappel, Robert D. Rece
  • Patent number: 5126150
    Abstract: Calcium lactate coated psyllium fiber composition and psyllium-containing baked cookie composition having high fiber content and good eating qualities. These baked cookies comprise calcium lactate coated psyllium fiber, insoluble dietary fiber, shortening, flour, sugar and water. Eating quality of these psyllium-containing cookies is especially enhanced by their reduced tendency for the composition to stick to and/or form a film on teeth during ingestion.
    Type: Grant
    Filed: October 1, 1990
    Date of Patent: June 30, 1992
    Assignee: The Procter & Gamble Company
    Inventors: David M. Piatt, Julia M. Courts, Mary M. Fox
  • Patent number: 5126143
    Abstract: Bowel movement-improving food products incorporating dietary fibers in total amount of 10 to 50% by weight based on the whole products, said dietary fibers comprising hardly water-soluble dietary fibers and readily water-soluble dietary fibers at a ratio of 1:2-30 parts by weight and 10% by weight or more of the former being hemicellulose. The food products of the invention are useful for preventing and treating constipation of both proctosenous and colonic types.
    Type: Grant
    Filed: December 6, 1989
    Date of Patent: June 30, 1992
    Assignee: Terumo Kabushiki Kaisha
    Inventors: Hiroshi Nakashima, Takuji Gotoh
  • Patent number: 5124144
    Abstract: The invention provides an orally administered pharmaceutical composition for use in gastrointestinal washes, particularly for diagnostic use, or as a cathartic laxative, of the type containing polyethyleneglycol, anhydrous sodium sulphate, sodium bicarbonate, sodium chloride and potassium chloride, characterized by also containing the following components: saccharin, acesulfame-K and a flavoring chosen from the following: mandarin, fresh fruit flavoring.
    Type: Grant
    Filed: April 11, 1990
    Date of Patent: June 23, 1992
    Assignee: Giuliani S.p.A.
    Inventors: Enzo Giorgetti, Virginio Castagnola, deceased, Giuliano Frigerio
  • Patent number: 5114709
    Abstract: The invention is concerned with a metal ion coordinated polyamine resin in which a non-toxic, pharmaceutically acceptable chelating metal ion is coordinated with a cross-linked and non-digestible polymeric amine selected from the group consisting of: (a) polyamine resins with a hydrophilic backbone, of the formula: ##STR1## wherein P represents a hydrophilic, cross-linked and non-digestible homopolymer backbone, m is an integer varying from 1 to 10 inclusive, and n, o and p are, independently, integers varying from 2 to 12 inclusive; (b) polyamine resins with a hydrophobic backbone, of the formula:P'--[NH(CH.sub.2).sub.n ].sub.m NH.sub.2 (II)wherein P' represents a hydrophobic, cross-linked and non-digestible homopolymer backbone, m is an integer varying from 0 to 6 inclusive and n is an integer varying from 2 to 12 inclusive; and (c) cross-linked copolymers of a polyethylenepolyamine containing from 2 to 6 ethylene units and epichlorohydrin.
    Type: Grant
    Filed: June 12, 1991
    Date of Patent: May 19, 1992
    Assignee: Lowchol Scientific Inc.
    Inventors: Leon E. St. Pierre, George R. Brown, Gaoming Wu, Youlu Yu
  • Patent number: 5077048
    Abstract: A bowel lavage composition which comprises one or more of a water-soluble polymer selected from the group consisting of polyethylene glycol, dextran, dextrin, hydroxyethylated starch, polydextrose, arabic gum, pullulan and pectin; a sodium salt of an organic; a potassium salt of an organic acid; sodium chloride; potassium chloride and sodium sulfate, having the following formulation:______________________________________ Water-soluble polymer 10-150 g Sodium salt of an organic acid 5-60 mmol Potassium salt of an organic acid 0-12 mmol Sodium chloride 7-60 mmol Potassium chloride 0-12 mmol Sodium sulfate 0-20 mmol ______________________________________wherein total potassium ion content in said composition ranges from 2 to 12 mEq.
    Type: Grant
    Filed: January 12, 1990
    Date of Patent: December 31, 1991
    Assignee: Morishita Pharmaceutical Co., Ltd.
    Inventors: Isami Kimura, Akemi Kamiya, Sumihiro Shiraishi, Makoto Sato
  • Patent number: 5073370
    Abstract: A natural fiber laxative is provided which consists of psyllium husk, apple fiber, fructose, gum arabic and flavorants. The psyllium husk and the apple fiber constitute together at least 75% by weight of the composition. The granular components are controlled to have a particle size less than that determined by a No. 50 mesh, thereby improving mouthfeel. The composition is, in addition to being all natural, low in calorie and high in fiber and when mixed with water has a palatable mouthfeel.
    Type: Grant
    Filed: February 22, 1991
    Date of Patent: December 17, 1991
    Assignee: Meer Corporation
    Inventors: E. Harvey Meer, Frank Mountain, Herbert V. Schultz
  • Patent number: 5039707
    Abstract: A method for causing laxation using 1, 3, 6, 8-tetrahydroxyanthraquinone.
    Type: Grant
    Filed: September 8, 1989
    Date of Patent: August 13, 1991
    Inventor: James R. Mobley
  • Patent number: 5034378
    Abstract: Food flavor enhancer composition which may be comprised of a variety or any one of edible salts including sodium chloride, potassium chloride, monosodium glutamate, flavor potentiators and at least one variety of soluble dietary fibers which is preferably decomplexed is specified.Improved potassium chloride, either alone or in combination with other edible salts together with soluble dietary fibers blended in accordance with the foregoing Examples, produces a composition which is much more similar to sodium chloride than heretofore known and/or possible.In a preferred form, hypocholesteremic soluble dietary fibers and salt compositions are also specified.
    Type: Grant
    Filed: December 15, 1988
    Date of Patent: July 23, 1991
    Assignee: James P. Cox
    Inventor: James P. Cox
  • Patent number: 4999200
    Abstract: A psyllium composition in tablet form is provided having a wetting agent, a disintegrant and a binding agent. In one embodiment, the wetting agent is polysorbate 80, the binding agent is polyvinyl pyrrolidone and the dry binding agent and disintegrant is microcrystalline cellulose. Calcium carbonate may also be added to serve as a disintegrant in HCL. The tablets are manufactured by mixing the psyllium powder with a solution of povidone and polysorbate 80. Microcrystalline cellulose may be added either during or after granulation. After mixing, the composition is compressed into tablet form. The mixing of the ingredients in specific quantities allows a tablet to be manufactured that is both resistant to fracture and at the same time disintegrates easily and quickly in the gastrointestinal tract of the patient.
    Type: Grant
    Filed: December 9, 1987
    Date of Patent: March 12, 1991
    Assignee: Marion Laboratories
    Inventor: Angel Casillan
  • Patent number: 4996051
    Abstract: A natural fiber laxative is provided which consists of psyllium husk, apple fiber, fructose, gum arabic and flavorants. The psyllium husk and the apple fiber constitute together at least 75% by weight of the composiiton. The granular components are controlled to have a particle size less than that determined by a No. 50 mesh, thereby improving mouthfeel. The composition is, in addition to being all natural, low in calorie and high in fiber and when mixed with water has a palatable mouthfeel.
    Type: Grant
    Filed: November 23, 1988
    Date of Patent: February 26, 1991
    Assignee: Meer Corporation
    Inventors: E. Harvey Meer, Frank Mountain, Herbert V. Schultz
  • Patent number: 4978529
    Abstract: Powdered psyllium seek husks are rendered rapidly and uniformly dispersible in water by admixing a solvent selected from the group consisting of benzyl alcohol, propylene glycol, triacetin and mixtures thereof with powdered psyllium seed husks.
    Type: Grant
    Filed: May 25, 1988
    Date of Patent: December 18, 1990
    Inventor: John Denick, Jr.
  • Patent number: 4962094
    Abstract: Compositions useful in the treatment of dietary disorders, and as dietary additives to provide a source of fiber, of short chain fatty acids and as bulking agents in humans and animals, as well as methods of use therefor. The compositions are based on whole .beta.-glucans.
    Type: Grant
    Filed: October 28, 1988
    Date of Patent: October 9, 1990
    Assignee: Alpha Beta Technology, Inc.
    Inventors: Spiros Jamas, D. Davidson Easson, Jr., Bruce R. Bistrian
  • Patent number: 4931554
    Abstract: The invention relates to a method of preparing a solid composition of lactulose in a simple way. According to the invention lactulose syrup is mixed with Fiberform.RTM., i.e. a fibre product based on the husks of corn grains having a fibre content of more than 80%. The mixture is spread, dried, crushed and optionally sieved.
    Type: Grant
    Filed: February 17, 1989
    Date of Patent: June 5, 1990
    Assignee: Duphar International Research B.V.
    Inventors: Hugo Bijl, Sebastiaan J. W. Vroklage
  • Patent number: 4877773
    Abstract: The present invention relate to compositions comprising 1/2 equal part epsom salt, 1 equal part molases syrup, 1 equal part castor oil and 1/2 equal part amorphous sulfur.
    Type: Grant
    Filed: April 29, 1987
    Date of Patent: October 31, 1989
    Inventor: Leola E. B. Turner
  • Patent number: 4839171
    Abstract: Composition for treating impaired lactation is described according to the preferred embodiment of the teachings of the present invention for oral administration to swine. The composition according to the teachings of the present invention includes blood albumin meal to provide a rich source of nutrients such as amino acids. Blood albuin helps insure that the osmotic pressure of the blood and interstitial tissue fluid around the mammary gland alveoli is optimized. Psyllium seed is further provided in the composition according to the teachings of the present invention as a natural laxative and as an effective aid in the treatment of constipation. Specifically, an oily, mucilaginous mass is formed when the psyllium seed comes in contact with water or fluid in the digestive tract and lubricates the digestive tract to help stimulate evacuations.
    Type: Grant
    Filed: February 27, 1987
    Date of Patent: June 13, 1989
    Assignee: Techmix, Inc.
    Inventor: Martin J. Nelson
  • Patent number: 4831053
    Abstract: A prophylactic or therapeutic composition for hepatitis is disclosed comprising a prophylactically or therapeutically effective amount of a sesquiterpene compound represented by the formula (I) or (II) ##STR1## or a pharmaceutically acceptable salt thereof as an active ingredient, and a pharmaceutically acceptable carrier.
    Type: Grant
    Filed: August 3, 1987
    Date of Patent: May 16, 1989
    Assignee: Otsuka Pharmaceutical Co., Ltd.
    Inventors: Masanao Shinohara, Hirotsugu Kaise, Yoshimasa Nakano, Taketoshi Izawa, Yasuo Oshiro, Wasei Miyazaki
  • Patent number: 4826826
    Abstract: Methylated chitosans are used for the preparation of pharmaceutical compositions having improved laxative properties over commonly used laxative.Said products are advantageouisly employed also in the preparation of ophtalmic solutions.
    Type: Grant
    Filed: May 29, 1987
    Date of Patent: May 2, 1989
    Assignee: Establissement Texcontor
    Inventor: Franco Conti
  • Patent number: 4814172
    Abstract: There is provided a palatable pre-mixed bran drink comprising heat treated, degelled bran in the presence of hydrated colloidal magnesium aluminum silicate and an acidification agent. The drink has good mouthfeel and may be used as a bulk supplement to diet.
    Type: Grant
    Filed: October 29, 1987
    Date of Patent: March 21, 1989
    Assignee: Product Resources International, Inc.
    Inventors: Leonard Chavkin, Leonard Mackles
  • Patent number: 4732917
    Abstract: The present invention relates to an improved process for preparing sucrose encrusted methylcellulose particles which readily disperse in cold aqueous liquids. These encrusted particles are suitable for use in bulk laxative compositions. In the improved process, hot sucrose syrup is mixed with powdered methylcellulose, dried and milled.
    Type: Grant
    Filed: August 26, 1986
    Date of Patent: March 22, 1988
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Dhiren N. Shah, Gregory V. Hammer, Jack Domet
  • Patent number: 4731246
    Abstract: There is provided a palatable pre-mixed bran drink comprising heat treated, degelled bran in the presence of hydrated colloidal magnesium aluminum silicate and an acidification agent. The drink has good mouthfeel and may be used as a bulk supplement to diet.
    Type: Grant
    Filed: October 31, 1985
    Date of Patent: March 15, 1988
    Assignee: Product Resources International, Inc.
    Inventors: Leonard Chavkin, Leonard Mackles
  • Patent number: 4671823
    Abstract: The present invention relates to an improved process for preparing sucrose encrusted methylcellulose particles which readily disperse in cold aqueous liquids. These encrusted particles are suitable for use in bulk laxative compositions. In the improved process, hot sucrose syrup is mixed with powdered methylcellulose, dried and milled.
    Type: Grant
    Filed: August 26, 1986
    Date of Patent: June 9, 1987
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Dhiren N. Shah, Gregory V. Hammer, Jack Domet
  • Patent number: 4626287
    Abstract: The present invention relates to an improved process for preparing sucrose encrusted methylcellulose particles which readily disperse in cold aqueous liquids. These encrusted particles are suitable for use in bulk laxative compositions. In the improved process, hot sucrose syrup is mixed with powdered methylcellulose, dried and milled.
    Type: Grant
    Filed: January 29, 1985
    Date of Patent: December 2, 1986
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Dhiren N. Shah, Jack Domet, Gregory V. Hammer
  • Patent number: 4564615
    Abstract: An immunoactivator comprising an effective amount of a thiazolobenzoxazine derivative of the formula, or its salt ##STR1## wherein R.sup.1 represents a hydrogen atom, carboxyl group or lower alkoxycarbonyl group, R.sup.2 represents a substituted or unsubstituted phenyl group, lower alkyl group or furyl group, and R.sup.3 represents a hydrogen atom or lower alkoxy group.
    Type: Grant
    Filed: November 12, 1982
    Date of Patent: January 14, 1986
    Assignee: SS Pharmaceutical Co., Ltd.
    Inventors: Hideaki Matsuda, Ryohta Tatezaki, Hiroyuki Mizuno, Tatsuhiko Katori