Laxative Patents (Class 514/892)
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Patent number: 5425945Abstract: Agglomerated psyllium husk comprising edible acid uniformly dispersed throughout the agglomerating coating. Preferred are maltodextrin-containing agglomerates of psyllium husk comprising citric acid uniformly dispersed throughout the maltodextrin coating. This agglomerated psyllium husk has improved mixability and dispersibility in liquids.Type: GrantFiled: March 14, 1994Date of Patent: June 20, 1995Assignee: The Procter & Gamble CompanyInventor: Melvin A. Barbera
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Patent number: 5418220Abstract: The invention disclosed relates to the use of dimethicone as an agent for treating constipation.Type: GrantFiled: March 8, 1994Date of Patent: May 23, 1995Inventors: Alfred Schmidt, Hans-Jurgen Upmeyer
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Patent number: 5397573Abstract: Laxative compositions containing sennoside and menthol, pharmaceutically-acceptable esters of menthol, or mixtures thereof, preferably as peppermint oil; and methods for treating constipation by orally concurrently administering to the lower gastrointestinal tract of a person in need of such treatment sennoside and menthol.Type: GrantFiled: June 4, 1993Date of Patent: March 14, 1995Assignee: The Procter & Gamble CompanyInventors: Theresa M. Kajs, Paul J. Sagel
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Patent number: 5389372Abstract: A stable formulation of Sennosides with increased shelf-life and good solubility comprising a granulate containing Senna extract concentrate and, for each part by weight of Senna extract concentrate, 1 to 3 parts of weight of sucrose.Type: GrantFiled: November 10, 1993Date of Patent: February 14, 1995Assignee: ASTA Medica AktiengesellschaftInventors: Luigi deMaria, Claudio Lasciarrea, Pietro Micheli, Hein-Uwe Schmersahl
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Patent number: 5380717Abstract: A food composite performing a function of large bowel regulation and comprising a refined product of pyrodextrin obtained as an active ingredient through a process of decomposing starch or starch hydrolyzate by heating in the presence of an acid or without acid.Type: GrantFiled: August 17, 1993Date of Patent: January 10, 1995Assignee: Matsutani Chemical Industries Co., Ltd.Inventors: Kazuhiro Ohkuma, Shigeru Wakabayashi, Mitsuko Satouchi
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Patent number: 5364636Abstract: A drug for preventing the absorption of food materials dissolved during digestion, a drug for preventing obesity, a drug for treating hyperlipemia, a drug for treating diabetes mellitus, and a drug for preventing constipation, wherein the flocculant and other auxiliary additives at request, are coated with the aquatic enteric material.Type: GrantFiled: April 1, 1992Date of Patent: November 15, 1994Assignee: Hanabusa Patent OfficeInventor: Shigeo Ochi
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Patent number: 5340580Abstract: Agglomerated psyllium husk comprising edible acid uniformly dispersed throughout the agglomerating coating. Preferred are maltodextrin-containing agglomerates of psyllium husk comprising citric acid uniformly dispersed throughout the maltodextrin coating. This agglomerated psyllium husk has improved mixability and dispersibility in liquids.Type: GrantFiled: May 6, 1993Date of Patent: August 23, 1994Assignee: The Procter & Gamble CompanyInventor: Melvin A. Barbera
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Patent number: 5338549Abstract: Psyllium husk-containing powdered drink mix compositions comprising a free radical scavenging antioxidant material to reduce the incidence of vacuum generation in air tight containers and of off-odors.Type: GrantFiled: December 21, 1992Date of Patent: August 16, 1994Assignee: The Procter & Gamble CompanyInventors: Lee A. Hord, Robert E. Barron
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Patent number: 5320847Abstract: A high-fiber, consumable bulk fiber composition, which may be used as a laxative, comprises powdered psyllium husks agglomerated with a water soluble, low viscosity gum, preferably gum acacia, to form a dry, free-flowing, water dispersible dietary fiber combinate. To form the dietary fiber combinate, the powdered psyllium husks are mixed with an aqueous solution of the water soluble, low viscosity gum, preferably by fluid bed agglomeration, and dried. The composition is employed to treat constipation by ingesting an effective amount of the dietary fiber combinate dispersed in water.Type: GrantFiled: May 13, 1993Date of Patent: June 14, 1994Assignee: Valentine Enterprises, Inc.Inventors: William Valentine, William K. Valentine
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Patent number: 5274001Abstract: The present invention relates to orthostatic lavage solutions or colon evacuants for cleansing the gastrointestinal tract, or for treatment of bowel diseases and/or disorders, containing an effective amount of ascorbic acid or a salt thereof.Type: GrantFiled: July 17, 1990Date of Patent: December 28, 1993Inventor: Thomas J. Borody
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Patent number: 5266334Abstract: Water-dispersible sugar-free powdered, bulk laxative compositions containing cellulose ethers as the active agent are disclosed. These bulk laxative compositions form smooth, palatable dispersions in water which dispersions contain a therapeutically effective amount of the cellulose ether.Type: GrantFiled: July 29, 1992Date of Patent: November 30, 1993Assignee: Merrell Dow Pharmaceuticals Inc.Inventors: Deepak S. Phadke, Julie L. Collier
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Patent number: 5260283Abstract: Wheat bran fiber is used to alter the enterohepatic recirculation of estrogens leading to an increased fecal excretion of estrogens together with a decrease in urinary excretion of estrogens. Increased lipid excretion is also found. Thus wheat bran fiber is useful to remove estrogen and lipid in mammals.Type: GrantFiled: May 19, 1992Date of Patent: November 9, 1993Assignee: American Health FoundationInventors: Marcia E. Kendall, Leonard A. Cohen
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Patent number: 5250301Abstract: A liquid internal medicine contains only an extract from stems of natural Stevia plants. The medicine is particularly effective for curing disorders of the digestive organs. The medicine contains a liquid obtained by fermenting a concentrate of an extract from Stevia stems, and is administered to patients as is or after dilution. As the medicine contains only the natural component, it is free of any side effects when applied to patients.Type: GrantFiled: January 28, 1992Date of Patent: October 5, 1993Assignees: Fumio Dozono, Naohiko SatoInventor: Fumio Dozono
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Patent number: 5248502Abstract: A method of reducing the allergenicity of psyllium seed husk. Psyllium seed husk is treated with a alkaline solution at a temperature and for a time sufficient to reduce the allergenicity of the psyllium seed husk.Type: GrantFiled: November 8, 1991Date of Patent: September 28, 1993Assignee: Kellogg CompanyInventor: Louis I. Ndife
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Patent number: 5234916Abstract: Psyllium husk-containing drink mix compositions comprising the divalent cation salt of strong inorganic acids selected from the group consisting of magnesium sulfate, calcium sulfate, calcium chloride, zinc sulfate, zinc chloride and mixtures thereof.Type: GrantFiled: June 12, 1992Date of Patent: August 10, 1993Assignee: The Proctor & Gamble CompanyInventor: Lee A. Hord
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Patent number: 5232698Abstract: Psyllium husk-containing drink mix compositions comprising small particle size psyllium husk and edible, water soluble salts. The edible, water soluble salts are present at a level sufficient to reduce the gellation rate of the psyllium husk when dispersed in an aqueous solution.Type: GrantFiled: June 12, 1992Date of Patent: August 3, 1993Assignee: The Proctor & Gamble CompanyInventor: Lee A. Hord
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Patent number: 5232699Abstract: The present invention relates to laxative compositions comprising psyllium and sennoside wherein sennoside is dispersed in a palatable food grade fat having a melting point within the range of from about 30.degree. C. to about 50.degree. C.Type: GrantFiled: June 19, 1992Date of Patent: August 3, 1993Assignee: The Proctor & Gamble CompanyInventor: John A. Colliopoulos
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Patent number: 5219573Abstract: The present invention relates to novel monosaccharide sweeteners which are capable of acting as laxatives when administered in dose-effective amounts. The present invention also contemplates monosaccharides with laxative properties which have a natural carbohydrate structure. More specifically, the present invention contemplates monosaccharide substances capable of producing laxative effects in humans and having the advantages of being only minimally absorbed from the intestine; and having osmotic laxative effects on the small bowel and colon. The present invention allows for improved laxative formulations with increased palatability and better dosing for all age groups. The present invention can be used to induce mild laxation six to ten hours after ingestion.Type: GrantFiled: October 17, 1989Date of Patent: June 15, 1993Assignee: Hershey Foods CorporationInventors: Stanley M. Tarka, Jr., Carol A. Shively, Joan L. Apgar, Kenneth L. Koch
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Patent number: 5219570Abstract: Agglomerated psyllium husk comprising edible acid uniformly dispersed throughout the agglomerating coating. Preferred are maltodextrin-containing agglomerates of psyllium husk comprising citric acid uniformly dispersed throughout the maltodextrin coating. This agglomerated psyllium husk has improved mixability and dispersilibity in liquids.Type: GrantFiled: March 25, 1992Date of Patent: June 15, 1993Assignee: The Procter & Gamble CompanyInventor: Melvin A. Barbera
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Patent number: 5206355Abstract: Sucrose is treated with an acid catalyst to form an amorphous sucrose anhydrous melt. Heating of the anhydrous melt at 80.degree.-100.degree. C. forms three known kestoses and the novel products, viz. .alpha.-fructosylsucrose anomers of 6-kestose, neokestose, and 1-kestose. Heating of the anhydrous melt at 125.degree.-175.degree. C. produces a fructoglucan sucrose polymer having a molecular weight of about 2,000 to 10,000 Daltons. All of these products are useful as sweeteners, food additives, additives for animal food, and bulking agents.Type: GrantFiled: March 19, 1992Date of Patent: April 27, 1993Assignee: The University of MontanaInventors: Geoffrey N. Richards, Merilyn Manley-Harris
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Patent number: 5149541Abstract: Psyllium husk comprising particle sizes distributed such that: less than about 15% is larger than about 80 mesh, at least about 45% is within the range of from about 80 mesh to about 200 mesh, and less than about 40% is smaller than about 200 mesh. In addition, psyllium-containing products for oral administration comprising small particle size psyllium husk according to the present invention are described.Type: GrantFiled: February 20, 1991Date of Patent: September 22, 1992Assignee: The Procter & Gamble CompanyInventors: Paul D. Leis, Jr., Larry E. Burns, Karen R. Hafer
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Patent number: 5143728Abstract: Psyllium-containing filling compositions having excellent texture, mouthfeel, and palatability. These filling compositions essentially comprise psyllium fiber and higher levels of glycerin, and preferably comprise sweeteners and flavorants. Furthermore, they have water activities ("A.sub.W ") below about 0.35. The compositions are ingested to control constipation, bowel function, blood cholestrol levels, glood glucose tolerance, and/or appetite, as well as for prophylaxis and treatment of intestinal disorders.Type: GrantFiled: May 1, 1991Date of Patent: September 1, 1992Assignee: The Procter & Gamble CompanyInventors: James W. Cappel, Robert D. Rece
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Patent number: 5126150Abstract: Calcium lactate coated psyllium fiber composition and psyllium-containing baked cookie composition having high fiber content and good eating qualities. These baked cookies comprise calcium lactate coated psyllium fiber, insoluble dietary fiber, shortening, flour, sugar and water. Eating quality of these psyllium-containing cookies is especially enhanced by their reduced tendency for the composition to stick to and/or form a film on teeth during ingestion.Type: GrantFiled: October 1, 1990Date of Patent: June 30, 1992Assignee: The Procter & Gamble CompanyInventors: David M. Piatt, Julia M. Courts, Mary M. Fox
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Patent number: 5126143Abstract: Bowel movement-improving food products incorporating dietary fibers in total amount of 10 to 50% by weight based on the whole products, said dietary fibers comprising hardly water-soluble dietary fibers and readily water-soluble dietary fibers at a ratio of 1:2-30 parts by weight and 10% by weight or more of the former being hemicellulose. The food products of the invention are useful for preventing and treating constipation of both proctosenous and colonic types.Type: GrantFiled: December 6, 1989Date of Patent: June 30, 1992Assignee: Terumo Kabushiki KaishaInventors: Hiroshi Nakashima, Takuji Gotoh
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Patent number: 5124144Abstract: The invention provides an orally administered pharmaceutical composition for use in gastrointestinal washes, particularly for diagnostic use, or as a cathartic laxative, of the type containing polyethyleneglycol, anhydrous sodium sulphate, sodium bicarbonate, sodium chloride and potassium chloride, characterized by also containing the following components: saccharin, acesulfame-K and a flavoring chosen from the following: mandarin, fresh fruit flavoring.Type: GrantFiled: April 11, 1990Date of Patent: June 23, 1992Assignee: Giuliani S.p.A.Inventors: Enzo Giorgetti, Virginio Castagnola, deceased, Giuliano Frigerio
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Patent number: 5114709Abstract: The invention is concerned with a metal ion coordinated polyamine resin in which a non-toxic, pharmaceutically acceptable chelating metal ion is coordinated with a cross-linked and non-digestible polymeric amine selected from the group consisting of: (a) polyamine resins with a hydrophilic backbone, of the formula: ##STR1## wherein P represents a hydrophilic, cross-linked and non-digestible homopolymer backbone, m is an integer varying from 1 to 10 inclusive, and n, o and p are, independently, integers varying from 2 to 12 inclusive; (b) polyamine resins with a hydrophobic backbone, of the formula:P'--[NH(CH.sub.2).sub.n ].sub.m NH.sub.2 (II)wherein P' represents a hydrophobic, cross-linked and non-digestible homopolymer backbone, m is an integer varying from 0 to 6 inclusive and n is an integer varying from 2 to 12 inclusive; and (c) cross-linked copolymers of a polyethylenepolyamine containing from 2 to 6 ethylene units and epichlorohydrin.Type: GrantFiled: June 12, 1991Date of Patent: May 19, 1992Assignee: Lowchol Scientific Inc.Inventors: Leon E. St. Pierre, George R. Brown, Gaoming Wu, Youlu Yu
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Patent number: 5077048Abstract: A bowel lavage composition which comprises one or more of a water-soluble polymer selected from the group consisting of polyethylene glycol, dextran, dextrin, hydroxyethylated starch, polydextrose, arabic gum, pullulan and pectin; a sodium salt of an organic; a potassium salt of an organic acid; sodium chloride; potassium chloride and sodium sulfate, having the following formulation:______________________________________ Water-soluble polymer 10-150 g Sodium salt of an organic acid 5-60 mmol Potassium salt of an organic acid 0-12 mmol Sodium chloride 7-60 mmol Potassium chloride 0-12 mmol Sodium sulfate 0-20 mmol ______________________________________wherein total potassium ion content in said composition ranges from 2 to 12 mEq.Type: GrantFiled: January 12, 1990Date of Patent: December 31, 1991Assignee: Morishita Pharmaceutical Co., Ltd.Inventors: Isami Kimura, Akemi Kamiya, Sumihiro Shiraishi, Makoto Sato
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Patent number: 5073370Abstract: A natural fiber laxative is provided which consists of psyllium husk, apple fiber, fructose, gum arabic and flavorants. The psyllium husk and the apple fiber constitute together at least 75% by weight of the composition. The granular components are controlled to have a particle size less than that determined by a No. 50 mesh, thereby improving mouthfeel. The composition is, in addition to being all natural, low in calorie and high in fiber and when mixed with water has a palatable mouthfeel.Type: GrantFiled: February 22, 1991Date of Patent: December 17, 1991Assignee: Meer CorporationInventors: E. Harvey Meer, Frank Mountain, Herbert V. Schultz
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Patent number: 5039707Abstract: A method for causing laxation using 1, 3, 6, 8-tetrahydroxyanthraquinone.Type: GrantFiled: September 8, 1989Date of Patent: August 13, 1991Inventor: James R. Mobley
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Patent number: 5034378Abstract: Food flavor enhancer composition which may be comprised of a variety or any one of edible salts including sodium chloride, potassium chloride, monosodium glutamate, flavor potentiators and at least one variety of soluble dietary fibers which is preferably decomplexed is specified.Improved potassium chloride, either alone or in combination with other edible salts together with soluble dietary fibers blended in accordance with the foregoing Examples, produces a composition which is much more similar to sodium chloride than heretofore known and/or possible.In a preferred form, hypocholesteremic soluble dietary fibers and salt compositions are also specified.Type: GrantFiled: December 15, 1988Date of Patent: July 23, 1991Assignee: James P. CoxInventor: James P. Cox
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Patent number: 4999200Abstract: A psyllium composition in tablet form is provided having a wetting agent, a disintegrant and a binding agent. In one embodiment, the wetting agent is polysorbate 80, the binding agent is polyvinyl pyrrolidone and the dry binding agent and disintegrant is microcrystalline cellulose. Calcium carbonate may also be added to serve as a disintegrant in HCL. The tablets are manufactured by mixing the psyllium powder with a solution of povidone and polysorbate 80. Microcrystalline cellulose may be added either during or after granulation. After mixing, the composition is compressed into tablet form. The mixing of the ingredients in specific quantities allows a tablet to be manufactured that is both resistant to fracture and at the same time disintegrates easily and quickly in the gastrointestinal tract of the patient.Type: GrantFiled: December 9, 1987Date of Patent: March 12, 1991Assignee: Marion LaboratoriesInventor: Angel Casillan
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Patent number: 4996051Abstract: A natural fiber laxative is provided which consists of psyllium husk, apple fiber, fructose, gum arabic and flavorants. The psyllium husk and the apple fiber constitute together at least 75% by weight of the composiiton. The granular components are controlled to have a particle size less than that determined by a No. 50 mesh, thereby improving mouthfeel. The composition is, in addition to being all natural, low in calorie and high in fiber and when mixed with water has a palatable mouthfeel.Type: GrantFiled: November 23, 1988Date of Patent: February 26, 1991Assignee: Meer CorporationInventors: E. Harvey Meer, Frank Mountain, Herbert V. Schultz
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Patent number: 4978529Abstract: Powdered psyllium seek husks are rendered rapidly and uniformly dispersible in water by admixing a solvent selected from the group consisting of benzyl alcohol, propylene glycol, triacetin and mixtures thereof with powdered psyllium seed husks.Type: GrantFiled: May 25, 1988Date of Patent: December 18, 1990Inventor: John Denick, Jr.
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Patent number: 4962094Abstract: Compositions useful in the treatment of dietary disorders, and as dietary additives to provide a source of fiber, of short chain fatty acids and as bulking agents in humans and animals, as well as methods of use therefor. The compositions are based on whole .beta.-glucans.Type: GrantFiled: October 28, 1988Date of Patent: October 9, 1990Assignee: Alpha Beta Technology, Inc.Inventors: Spiros Jamas, D. Davidson Easson, Jr., Bruce R. Bistrian
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Patent number: 4931554Abstract: The invention relates to a method of preparing a solid composition of lactulose in a simple way. According to the invention lactulose syrup is mixed with Fiberform.RTM., i.e. a fibre product based on the husks of corn grains having a fibre content of more than 80%. The mixture is spread, dried, crushed and optionally sieved.Type: GrantFiled: February 17, 1989Date of Patent: June 5, 1990Assignee: Duphar International Research B.V.Inventors: Hugo Bijl, Sebastiaan J. W. Vroklage
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Patent number: 4877773Abstract: The present invention relate to compositions comprising 1/2 equal part epsom salt, 1 equal part molases syrup, 1 equal part castor oil and 1/2 equal part amorphous sulfur.Type: GrantFiled: April 29, 1987Date of Patent: October 31, 1989Inventor: Leola E. B. Turner
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Patent number: 4839171Abstract: Composition for treating impaired lactation is described according to the preferred embodiment of the teachings of the present invention for oral administration to swine. The composition according to the teachings of the present invention includes blood albumin meal to provide a rich source of nutrients such as amino acids. Blood albuin helps insure that the osmotic pressure of the blood and interstitial tissue fluid around the mammary gland alveoli is optimized. Psyllium seed is further provided in the composition according to the teachings of the present invention as a natural laxative and as an effective aid in the treatment of constipation. Specifically, an oily, mucilaginous mass is formed when the psyllium seed comes in contact with water or fluid in the digestive tract and lubricates the digestive tract to help stimulate evacuations.Type: GrantFiled: February 27, 1987Date of Patent: June 13, 1989Assignee: Techmix, Inc.Inventor: Martin J. Nelson
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Patent number: 4831053Abstract: A prophylactic or therapeutic composition for hepatitis is disclosed comprising a prophylactically or therapeutically effective amount of a sesquiterpene compound represented by the formula (I) or (II) ##STR1## or a pharmaceutically acceptable salt thereof as an active ingredient, and a pharmaceutically acceptable carrier.Type: GrantFiled: August 3, 1987Date of Patent: May 16, 1989Assignee: Otsuka Pharmaceutical Co., Ltd.Inventors: Masanao Shinohara, Hirotsugu Kaise, Yoshimasa Nakano, Taketoshi Izawa, Yasuo Oshiro, Wasei Miyazaki
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Patent number: 4826826Abstract: Methylated chitosans are used for the preparation of pharmaceutical compositions having improved laxative properties over commonly used laxative.Said products are advantageouisly employed also in the preparation of ophtalmic solutions.Type: GrantFiled: May 29, 1987Date of Patent: May 2, 1989Assignee: Establissement TexcontorInventor: Franco Conti
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Patent number: 4814172Abstract: There is provided a palatable pre-mixed bran drink comprising heat treated, degelled bran in the presence of hydrated colloidal magnesium aluminum silicate and an acidification agent. The drink has good mouthfeel and may be used as a bulk supplement to diet.Type: GrantFiled: October 29, 1987Date of Patent: March 21, 1989Assignee: Product Resources International, Inc.Inventors: Leonard Chavkin, Leonard Mackles
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Patent number: 4732917Abstract: The present invention relates to an improved process for preparing sucrose encrusted methylcellulose particles which readily disperse in cold aqueous liquids. These encrusted particles are suitable for use in bulk laxative compositions. In the improved process, hot sucrose syrup is mixed with powdered methylcellulose, dried and milled.Type: GrantFiled: August 26, 1986Date of Patent: March 22, 1988Assignee: Merrell Dow Pharmaceuticals Inc.Inventors: Dhiren N. Shah, Gregory V. Hammer, Jack Domet
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Patent number: 4731246Abstract: There is provided a palatable pre-mixed bran drink comprising heat treated, degelled bran in the presence of hydrated colloidal magnesium aluminum silicate and an acidification agent. The drink has good mouthfeel and may be used as a bulk supplement to diet.Type: GrantFiled: October 31, 1985Date of Patent: March 15, 1988Assignee: Product Resources International, Inc.Inventors: Leonard Chavkin, Leonard Mackles
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Patent number: 4671823Abstract: The present invention relates to an improved process for preparing sucrose encrusted methylcellulose particles which readily disperse in cold aqueous liquids. These encrusted particles are suitable for use in bulk laxative compositions. In the improved process, hot sucrose syrup is mixed with powdered methylcellulose, dried and milled.Type: GrantFiled: August 26, 1986Date of Patent: June 9, 1987Assignee: Merrell Dow Pharmaceuticals Inc.Inventors: Dhiren N. Shah, Gregory V. Hammer, Jack Domet
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Patent number: 4626287Abstract: The present invention relates to an improved process for preparing sucrose encrusted methylcellulose particles which readily disperse in cold aqueous liquids. These encrusted particles are suitable for use in bulk laxative compositions. In the improved process, hot sucrose syrup is mixed with powdered methylcellulose, dried and milled.Type: GrantFiled: January 29, 1985Date of Patent: December 2, 1986Assignee: Merrell Dow Pharmaceuticals Inc.Inventors: Dhiren N. Shah, Jack Domet, Gregory V. Hammer
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Patent number: 4564615Abstract: An immunoactivator comprising an effective amount of a thiazolobenzoxazine derivative of the formula, or its salt ##STR1## wherein R.sup.1 represents a hydrogen atom, carboxyl group or lower alkoxycarbonyl group, R.sup.2 represents a substituted or unsubstituted phenyl group, lower alkyl group or furyl group, and R.sup.3 represents a hydrogen atom or lower alkoxy group.Type: GrantFiled: November 12, 1982Date of Patent: January 14, 1986Assignee: SS Pharmaceutical Co., Ltd.Inventors: Hideaki Matsuda, Ryohta Tatezaki, Hiroyuki Mizuno, Tatsuhiko Katori