Abstract: A scour-resistant interface enhancer, a preparation method, and an application thereof are provided. The scour-resistant interface enhancer is a compound solution prepared by using a 0.1% surfactant CAEO-15 and a 0.3% silane coupling agent as solutes and using clear water and absolute ethanol as solvents, where the mass ratio of clear water to absolute ethanol is 9:1. The scour-resistant interface enhancer of the present invention used as pre-flush for well cementing of coalbed methane wells has good wettability modification effect, shows scour-resistant effect against cement slurry, exhibits good compatibility with cement slurry system, and can significantly improve the cementing strength and air tightness of two interfaces of coal bed and effectively enhance the cementing quality of coalbed methane wells.

Abstract: The invention relates to a pharmaceutical formulation, in a composition and form suitable for intranasal administration as a spray or drops or gel, containing hydroxocobalamin and/or hydroxocobalamin salts dissolved in water, containing mannitol as main excipient and optionally some other excipients.

Abstract: The present disclosure relates to one or more agents, therapies, treatments, and methods of use of the agents and/or therapies and/or treatments for increasing production of a Cetuximab-like protein (CLP) by a subject that is administered the agent, therapy or treatment. Embodiments of the present disclosure can be used as a therapy or a treatment for a subject that has a condition that may benefit from reducing the DNA synthesis of genes that regulate cellular growth and proliferation.

Abstract: The present invention relates to a novel oil in water emulsion aerosol foam composition containing an active agent for the treatment of various chronic and acute skin conditions, particularly acne and psoriasis; and processes for preparing the emulsion aerosol foam compositions. In particular, the present invention relates to oil in water emulsion aerosol foam compositions containing a retinoid in the oil phase.

Abstract: Oil-in-water emulsions contain an oil dispersed phase, an aqueous continuous phase, and partly silylated pyrogenic silica having a content of silanol groups of 1.7 to 0.9 SiOH/nm2 wherein 50% to 95% of silanol groups of the starting silica are silylated, present at the interface between the dispersed phase and the continuous phase and an electrolyte content in the aqueous phase which establishes the viscosity of the emulsion.

Abstract: An emulsifying composition, characterised in that it contains by weight, excluding impurities, (i) 1 to 98% by weight of a mixture of alkyl glycosides R1O(G1)g1(G2)g2(G3)g3(G4)g4(G5)g5, (ii) 1 to 90% by weight of a mixture of alcohol esters R2OZ, (iii) 1 to 90% of an alcohol R3OH, and (iv) 4 to 90% of a mixture of alkyl glycoside esters R4O(X1)x1(Z)z1(X2)x2(Z)z2(X3)x3(Z)z3(X4)x4(Z)z4(X5)x5(Z)z5, is disclosed In accordance with the composition, R1 is a hydrocarbon radical, linear or branched, saturated or unsaturated, having 10 to 22 carbon atoms. G1, G2, G3, G4, G5 are identical or different residues of -oses selected from glucose, galactose, mannose, fructose, ribose, xylose and arabinose, g1, g2, g3, g4 and g5 being equal to 0 or 1, the sum of g1, g2, g3, g4 and g5 being at least equal to 1. The composition has emulsifying capacity in the presence of electrolytes or in the case of paraffin-based emulsions.

Abstract: The invention provides a polypeptide having a sequence of amino acids consisting of IXDFGLAKL (SEQ ID NO: 1), as well as a nucleic acid encoding the polypeptide, vector comprising the nucleic acid, cell comprising the vector, and compositions thereof. The invention also provides a method of inducing a T-cell response in a patient with epithelial cancer, and a method inhibiting epithelial cancer, wherein the methods comprise administering the composition of the invention. The invention further provides a method of stimulating a cell with the inventive polypeptide and a cell so stimulated.

Abstract: The invention relates to water-in-oil (W/O) or oil-in-water (O/W) emulsions containing an oil phase of at least one water-insoluble constituent; an aqueous phase; pyrogenic silica at the oil-water interface, the pyrogenic silica partially silylated such that non-silylated surface silanol groups remaining are between 95% and 5% of initial silanol groups, the equivalent of 1.7 to 0.1 surface SiOH groups per nm2, a surface energy gamma-s-D of 30 to 80 mJ/m2, and a specific BET surface area between 30 and 500 m2/g; and optionally other substances, such as pigments or preservatives. The inventive emulsions have a mean particle size of the dispersed phase, of between 0.5 ?m and 500 ?m, and are of low viscosity.

Abstract: The present invention relates to odour improved dermatological or cosmetic preparations comprising N-acetylcysteine and a polyol system containing one or more polyols as masking odour agents. The emulsions of the present invention are useful in the treatment of dermatological disorders or cosmetic skin conditions.

Abstract: A cosmetic preparation of the oil-in-water type whose oil phase comprises one or more mineral oils and which has a flow curve depicting the dynamic viscosity as a function of the shear stress showing a maximum of up to 10 000 Pas at a shear stress of from 5 to 50 Pa and a shoulder at a shear stress of from 30 to 110 Pa.

Abstract: Disclosed is a multi-compartment medical device useful in the storage, processing and extended shelf life of perishable products, especially pharmaceutical, food and biological products. Particular biological materials processed according to the present methods are human blood and blood products (RBCs). Also disclosed are processes for preserving food, pharmaceutical and biological products for long-term storage and extended shelf life employing a process that reduces the hydration level of the material to less than native hydration levels of the specific product. The invention further provides stabilized biological products, such as in the form of glassified beads, prepared using a two-phase system according to the described processes that may be rehydrated and prepared for clinical use, and having essentially no loss of biological and/or pharmacological activity.

Abstract: A self-reversible reverse microlatex composition comprising an oil phase, an aqueous phase, a water-in-oil surfactant(s), a oil-in-water surfactant(s) and 15% to 40% by weight by weight of a branched or crosslinked polyelectrolyte. The polyelectrolyte is based on a monomer containing a strong or weak acid function, which is partially or totally salified, a copolymer of at least one monomer containing a strong acid function and at least one monomer containing a weak acid function or at least one neutral monomer, a copolymer of at least one monomer containing a weak acid function and at least one neutral monomer, or a copolymer of at least one monomer containing a strong acid function, a monomer containing at least one weak acid function and at least one neutral monomer. The surfactants have a total HLB number of 8.5 to 11. Uses in cosmetics and as an industrial emulsifier and/or thickener.

Abstract: A process is described for the preparation of storage-stable, multiple emulsions of the water/oil/water (W/O/W) type which comprise one or more active ingredients. The process comprises the steps a) stirring the active ingredient into an aqueous phase, b) emulsifying the aqueous phase by passing the aqueous phase through a large-pored, porous membrane into an oil phase, c) phase inversion of the emulsion from b), by cooling the mixture at a cooling rate of at least 0.3 K/min, where an emulsifier is added either to the aqueous phase in a) or to the oil phase in b) or to both phases.

Abstract: The present invention relates to a starch emulsifier product prepared by sufficiently solubilizing a starch and subsequently sufficiently derivatizing the sufficiently solubilized starch product, in one embodiment by reacting the sufficiently solubilized starch with an alkenyl succinic anhydride. Such starch emulsifier products are useful as emulsifying and/or encapsulating agents, particularly in systems where high load and retention of the active ingredient, low surface oil exposure, and excellent oxidation resistance is desired.

Abstract: A composition, which may be used as an emulsifier or thickening agent for cosmetic and topical products, and its method of production. The composition is based upon one or more anionic polyelectrolytes formed from monomers with an acid functional group. The acid group may be a strong acid or weak acid, and partially or completely salified. A neutral monomer may also be present. Additionally, the composition includes one or more emulsifiers of the water-in-oil type and water.

Abstract: Methods for the formation of colloidal suspensions. The method includes combining an aqueous substance with a second substance that is normally immiscible with the aqueous substance, to form a mixture, and before, during or after the combining removing dissolved gases from one or both of the aqueous and second substance, whereby the aqueous and second substances mix and form a colloidal suspension. The methods for the formation of colloidal suspensions include methods for the formation of emulsions as well as particulate dispersions. The methods used to form the colloidal suspensions in accordance with the present invention produce colloidal suspensions that are stable for periods from an hour to several weeks in the absence of surfactants or stabilizing agents.

Abstract: A liquid carrier for topical administration is provided that contains a mineral oil, turpentine and, optionally, camphor, and optionally other terpenoid components containing pinene, and its use to provide an antifungal composition containing a mixture of antifungal essential oils and the carrier system, wherein the mixture of antifungal essential oils includes an effective amount of each of Eucalyptus globulus, peppermint, cedarwood, and Manuka; along with the use of this composition in the topical treatment of fungal infection, particularly of the nail.

Abstract: A liquid carrier for topical administration is provided that contains a mineral oil, turpentine and, optionally, camphor, and optionally other terpenoid components containing pinene, and its use to provide an antifungal composition a mixture of antifungal essential oils and the carrier system, wherein the mixture of antifungal essential oils includes an effective amount of each of eucalyptus globulus, peppermint, cedarwood, and Manuka; along with the use of this composition in the topical treatment of fungal infection, particularly of the nail.

Abstract: The present invention is a sunscreen composition that has at least one sunscreen agent and at least one glucoside emulsifier. The composition also has water. Preferably, the sunscreen composition also has at least one of the following additional components: an emulsifier other than glucoside, emollient, skin-feel additive, moisturizing agent, film former/waterproofing agent, pH adjuster/chelating agent, preservative, or any combinations thereof. The composition is a stable oil-in-water emulsion.

Abstract: A self-reversible reverse microlatex composition comprising an oil phase, an aqueous phase, at least one W/O surfactant, at least one O/W surfactant, and a branched or a crosslinked polyelectrolyte, wherein the W/O surfactant and the O/W surfactant mixture have a HLB from about 9.5 to about 10, and the polyelectrolyte is either a homopolymer or copolymer or a combination thereof based on at least one monomer containing a strong or weak acid function. Further, the composition may be used in the cosmetic, dermopharmaceutical, pharmaceutical, textile, paper, and/or paint industries, or as a thickener for printing pastes based on pigments or dyes.

Abstract: The present invention is an antiperspirant product, comprising: (a) an oil-in water microemulsion including an oil phase and a water phase and being substantially free of alcohol, said microemulsion further comprising: one or more oil-in-water emulsifiers selected from the group consisting of polyethoxylated oil-in-water emulsifiers, polypropoxylated oil-in-water emulsifiers and polyethoxylated and polypropoxylated oil-in-water emulsifiers, wherein said microemulsion has a total emulsifier content of less than 20% by weight, based on the total weight of the microemulsion, and one or more antiperspirants, having a total content of 5 to 40% by weight, based on the total weight of the microemulsion, wherein said microemulsion is prepared by bringing a mixture comprising the water phase, the oil phase, and the one or more oil-in-water emulsifiers to a temperature within or above the phase-inversion temperature range, and subsequently cooling it to room temperature, and (b) a pump atomizer, comprising: a co

Abstract: A cosmetic or dermatological composition for preventing excessive odor and sweat secretion by skin, comprising an optically translucent to transparent, substantially alcohol-free oil-in-water type emulsion gel which comprises a polyethoxylated and/or a polypropoxylated O/W emulsifier, a polyol and a antiperspirant. This abstract is neither intended to define the invention disclosed in this specification nor intended to limit the scope of the invention in any way.

Abstract: The present invention relates to methods for regulating the condition of mammalian keratinous tissue wherein the methods each comprise the step of topically applying to the keratinous tissue of a mammal needing such treatment, a safe and effective amount of a skin care composition comprising: a) a safe and effective amount of a vitamin B6 compound selected from the group consisting of pyridoxine, esters of pyridoxine, amines of pyridoxine, salts of pyridoxine and derivatives thereof, including pyridoxamine, pyridoxal, pyridoxal phosphate, and pyridoxic acid; b) a safe and effective amount of a skin care active selected from the group consisting of peptides, phytosterol, sugar amines, their derivatives, and combinations thereof; and c) a dermatologically acceptable carrier for the pyridoxine and the skin care active.

Abstract: The preparation of novel microemulsions to be used as precursors for solid nanoparticles is described. The microemulsion precursors consist of either alcohol-in-fluorocarbon microemulsions, liquid hydrocarbon-in-fluorocarbon microemulsions, or liquid hydrocarbon-in-water microemulsions. The formed solid nanoparticles have diameters below 200 nanometers and can be made to entrap various materials including drugs, magnets, and sensors. The solid nanoparticles can be made to target different cells in the body by the inclusion of a cell-specific targeting ligand. Methods of preparing the novel microemulsion precursors and methods to cure solid nanoparticles are provided.

Abstract: A method for producing a colored cosmetic composition having inorganic pigments resistant to agglomeration in an oil-in-water emulsion. The method includes the following: preparing an oil dispersion by adding inorganic pigments directly to an oil; preparing an aqueous base that includes water; combining the oil dispersion and aqueous base; and partitioning the inorganic pigments between the oil and the aqueous phase under controlled conditions, for example, hydrophile-lipophile balance, agitation time and speed, and cooling rate. The present invention provides a process to easily disperse iron-oxide pigments, even black iron-oxide pigments, in oil-in-water emulsions. The present invention provides colored cosmetic compositions that have excellent properties, such as smoothness, adhesion to skin, uniform color, ease of removal, smudge resistance and non-oiliness.

Abstract: A composition and method for a linear or crosslinked cationic polyelectrolyte, involving copolymerization of at least one cationic monomer with at least one neutral monomer and at least one nonionic surfactant monomer.

Abstract: A thermally reversible water in oil in water (W/O/W) emulsion including a thermally reversible viscosifying polymer in the continuous aqueous phase of the emulsion. The thermally reversible viscosifying polymer of the W/O/W emulsion includes a block copolymer having at least a first polyoxyalkylene block having a hydrophobic region and a hydrophilic region effective to form micelles in solution in response to a change in temperature, and at least a second block comprising a poly(vinylcarboxylic acid).

Abstract: Thickeners for oil-containing compositions, particularly cosmetic and personal care compositions, are side chain crystalline polymers which are uniformly dispersed as a crystallized solid in the oil.

Abstract: A W/O/W type composite emulsion, wherein a W/O type emulsion containing water, an oil ingredient and a lipophilic emulsifier each in a proportion expressed in term of mass ratio falling within a range enclosed with bold lines in FIG. 1 is dispersed in an external aqueous phase with a water-soluble macromolecule blended therein has a sufficient stability, and permits preserving a percent inclusion of medical substances included in an internal aqueous phase of the W/O/W type composite emulsion at a high level. Because of the characteristics, it is now possible to blend in a liquid formulation medical substances having an unfavorable taste or unstable medical substances which have to date hardly been included in liquid formulations with low viscosity, so that the W/O/W type composite emulsion can be utilized for liquid formulations including a liquid formulation for internal application, injections, etc.

Abstract: A particle with two regions, the first region contains a detoxifying enzyme and a second region that partitions toxic compounds. The particle may be a nanoparticle.

Abstract: Provided is a method of formulating hydrophobic pesticides comprising emulsifying an aqueous phase and a water-immiscible phase to form a formulation; wherein the aqueous phase is comprised of water and optionally a freeze/thaw agent, one or more emulsifiers, or combinations thereof, and the water-immiscible phase comprises the hydrophobic pesticide and one or more emulsifiers.

Abstract: A flexible applicator for applying an oil-in-water emulsion comprises: (1) an allantoin-containing oil-in-water emulsion; and (2) a flexible element that adsorbs or absorbs the emulsion such that the emulsion is applied to the skin of a patient on whom the flexible applicator is placed. The allantoin-containing emulsion, containing allantoin and an emulsifier, has improved stability coming from the adjustment of the pH to a range of 3.0 to 6.0; preferably, the pH is in the range of 4.5 to about 5.8. The lower pH preserves the stability of the allantoin and the functionality of the emulsifier system is maintained. The emulsifier system can be a nonionic emulsifier or an anionic emulsifier plus beeswax. The acid used to adjust the pH can be an organic acid or an inorganic acid. The emulsion can further comprise other ingredients such as herbal extracts, chelating agents, preservatives, emollients, solvents, and fragrance.

Abstract: A cosmetic composition containing a retinoid and having an improved stability and mildness. Especially preferred compositions also include retinoid boosters and a polyhydric alcohol humectant.

Abstract: An allantoin-containing skin cream composition can comprise allantoin and at least one anionic or nonionic emulsifier that is substantially hydrophilic and is soluble in water. The pH of the composition is in a range of from about 3.0 to about 6.0; preferably, the pH of the composition is from about 5.0 to about 6.0. The composition can further comprise an acidic anionic polymer. A preferred acidic anionic polymer is a carboxypolymethylene polymer. The composition can further comprise a carbohydrate polymer such as galactoarabinan, polygalactose or polyarabinose. The composition can additionally comprise other ingredients such as herbal extracts, an antioxidant component, an emollient component, a chelator, a solvent component, or a preservative component. The composition is useful as a skin protectant.

Abstract: Disclosed are formulations for topical application, the formulation comprising a C15 branched polyalphaolefin, an aqueous phase, a non-aqueous phase, and at least one sunscreen active agent, alone or in combination with an insect repellant.

Abstract: Personal care or cosmetic oil in water emulsions include an oil emulsifier and a combination of a Xanthan polysaccharide and a polyglucomannan polysaccharide to provide enhanced stability even at low emulsifier stabiliser levels. The emulsifier stabiliser system provides stable emulsions without dominating system rheology, particularly viscosity. Thus, the emulsions can have a low viscosity suitable for formulation as milks or thin lotions, or can be thickened, desirably by thickening agents other than the Xanthan and/or polyglucomannan, to provide emulsion creams or gels. This enables the system to be used very flexibly in end use applications. The emulsifier is desirably a non-ionic emulsifier and particularly is a combination of a low HLB and a high HLB emulsifier and can be formulated with conventional alcohol ethoxylate surfactants or from non-EO surfactants e.g. sucrose ester high HLB surfactants and citrate or sorbitan ester low HLB surfactants.

Abstract: The present invention is a sunscreen composition that has at least one sunscreen agent and at least one glucoside emulsifier. The composition also has water. Preferably, the sunscreen composition also has at least one of the following additional components: emulsifier other than glucoside, emollient, skin-feel additive, moisturizing agent, film former/waterproofing agent, pH adjuster/chelating agent, preservative, or any combinations thereof. The composition is a stable oil-in-water emulsion.

Abstract: The present invention relates to synthetic, novel, preferably fatty phosphoric acid esters which, when neutralized with a neutralizing agent, is revealed as a new surface active agent. Formulations are presented which demonstrate a method for using the disclosed surface active agent to prepare stable oil-in-water, water-in-oil emulsions and various solutions of varying polarity and viscosity for use in a variety of dermatological applications, and/or wherever emulsions or solutions according to the present invention may be used.

Abstract: Use of a polyamino polymer to inhibit the light-induced peroxidation of lipids, particularly inhibition of the photo-peroxidation of lipids induced by nanopigments. The invention also relates to the use of a polyamino polymer to inhibit the light-induced peroxidation of proteins. This property of polyamino polymers finds applications in particular in the cosmetics, pharmaceutical, veterinary and agrifood fields.

Abstract: The present invention is a process of preparing an advanced cosmetic product by combining a high internal phase ratio (HIPR) emollient-in-water emulsion with a partial cosmetic formulation that typically contains water, fragrance, a rheology modifier, or a pH adjuster, or a combination thereof. The present invention is also a composition comprising two particular subclasses of HIPR emollient-in-water emulsions, namely an HIPR silicone elastomer-in-water emulsion and an HIPR sunscreen-in-water emulsion. The use of an HIPR emulsion of a cosmetic emollient provides a simple and flexible method of formulating the cosmetic product, due in part to the long shelf-stability of the HIPR emulsion (>1 year), and the low quantity of water in the emulsion (typically less than 20% by volume based on the volume of emollient and water).

Abstract: One aspect of the invention relates to anti-viral composition containing at least one zinc compound and at least one phenolic antioxidant (and optionally other ingredients such as at least one analgesic) at least one hydrocarbyl containing compound, and water. Another aspect of the invention relates to a method of treating lesionous symptoms of a viral infection involving applying an effective amount of the zinc containing anti-viral composition to the lesions.

Abstract: Described is a method for preparing sunscreening compositions that contain chlorphenesin as a biocidal preservative, wherein the chlorphenesin is dissolved in water-insoluble components.

Abstract: A gel formulation is combined with a bactericidal concentrate which is a liquid mixture of about 1000 parts by volume of ultra pure water having an electrical resistance of 16-26 megohms, total dissolved solids of less than 0.04 parts per million and a specific conductance of less than 0.10 mho with about 1.2 to 3 parts by volume of Willard Water as prepared in accordance with U.S. Pat. No. 3,893,943. The bactericidal liquid concentrate in the amount of 3.5 to 12 ml in one liter of gel formulation is applied directly to a skin surface area having a burn or other dermal lesion to protect the area from bacterial contamination.

Abstract: An improved method of treating skin diseases comprises applying to the skin of a patient suffering such a skin disease an allantoin-containing composition in a therapeutically effective quantity. The allantoin-containing composition is a water-in-oil emulsion that includes allantoin and an emulsifier system that includes at least one emulsifier that is either an anionic emulsifier or a nonionic emulsifier. If the emulsifier is an anionic emulsifier, the emulsifier system can include beeswax. The nonionic emulsifiers used can include at least one nonionic emulsifier that is an ethoxylated ether or an ethoxylated ester whose carbon chain length ranges from 8 to 22 carbon atoms. Alternatively, the emulsifier system can include an acidic anionic polymer such as carboxypolymethylene and an anionic emulsifier. In another alternative, the emulsifier system can include the acidic anionic polymer and a nonionic emulsifier, or the acidic anionic polymer alone.

Abstract: Topical analgesics, generally comprising calendula oil and cornmint oil, and methods of use.

Abstract: Use of a polyamino polymer to inhibit the light-induced peroxidation of lipids, particularly inhibition of the photo-peroxidation of lipids induced by nanopigments. The invention also relates to the use of a polyamino polymer to inhibit the light-induced peroxidation of proteins. This property of polyamino polymers finds applications in particular in the cosmetics, pharmaceutical, veterinary and agrifood fields.

Abstract: There is provided an emulsion having a substantially non-aqueous phase, a substantially aqueous phase, a vitamin C component and a pigment. Such an emulsion is both cosmetically and aesthetically acceptable.

Abstract: The invention relates to emulsion bases containing (a) polyol poly-12-polyhydroxystearates, (b) polyol esters selected from the group consisting of sorbitan esters, oligoglycerol esters and partial glycerides, (c) citric acid esters, (d) waxes and (e) metal soaps. The emulsion bases are distinguished by the fact that they enable both stable creams and lotions to be produced, irrespective of the polarity of the oils combined therewith.

Abstract: A tocotrienol-containing powder prepared by a process wherein an oil containing a tocotrienol is treated with a lecithin, a cellulose and an emulsifying agent in water to form an emulsion, a powder substance is mixed with the formed emulsion to form a suspension and then the formed suspension is spray-dried. The powder containing tocotrienol, which has excellent storage stability and free flowability, can be used in preparing a tablet which comprises the powder compressed into a tablet form.

Abstract: Emulsifier-free cosmetic or dermatological preparations, which are finely dispersed systems of the oil-in-water type, comprising 1. an oil phase, 2. an aqueous phase and 3. one or more types of micronized, inorganic pigments which a) have an average particle size of less than 200 nm, and whose particles b) have both hydrophilic and lipophilic properties, i.e. have an amphiphilic character, and thus position themselves at the water/oil interface, and which c) are selected from the group consisting of metal oxides, which d) are optionally coated on the surface and also optionally comprising further cosmetic or pharmaceutical auxiliaries, additives and/or active ingredients.