Abstract: The invention relates to compositions suitable for the delivery and/or stabilization of biologically active substances. The compositions comprise a sublimable matrix material and the biologically active agent to be delivered. The compositions can be used as drug delivery systems to treat a wide variety of diseases or as systems for the protection and stabilization of such substances. Also disclosed are methods for preparing compositions of the present invention.

Abstract: The invention relates to compositions and methods for treating or preventing vascular dementia in a mammal comprising mucosal administration of an amount of E-selectin polypeptide sufficient to induce bystander immune tolerance in the mammal. Another aspect of the invention relates to compositions useful for treating or preventing vascular dementia.

Abstract: The invention is directed to a method of administering hydrogen sulfide (H2S) slowly and sustainably to an individual in need thereof comprising administering an effective amount of a compound represented by the following structural formula: or a pharmaceutically acceptable salt thereof.

Abstract: The invention relates to compositions and methods for treating or preventing vascular dementia in a mammal comprising mucosal administration of an amount of E-selectin polypeptide sufficient to induce bystander immune tolerance in the mammal. Another aspect of the invention relates to compositions useful for treating or preventing vascular dementia.

Abstract: Disclosed are devices for dispensing air treatment chemicals. There is a substrate bearing a first volatile air treatment chemical that is capable of being dispensed from the substrate when the substrate is heated, and an indicator unit holding a volatile indicator chemical separate from the first volatile air treatment chemical such that the volatile indicator chemical is capable of being dispensed from the unit when the unit is heated. The extent of dispensing of the first volatile air treatment chemical can be indicated by a visible cue whose appearance results from the dispensing of the volatile indicator chemical. In one form the unit also holds a second air treatment chemical. In another the indicator unit is a replaceable cartridge positionable more remote from the heater than the substrate.

Abstract: There are provided safe, tasteless, odorless, non-aqueous liquid spray compositions formulated for administration to the nasal cavity consisting essentially of pharmacologically acceptable non aqueous liquid carrier in which said bioactive material is directly insoluble, a pharmacologically acceptable water insoluble ester of a water soluble acid soluble in said carrier, a pharmacologically acceptable water soluble glycol soluble in said ester and a pharmacologically acceptable water soluble bio-active material soluble in said glycol but not directly soluble in the carrier. There are also provided methods of producing and administering such compositions.

Abstract: An antifungal fragrance composition containing as its active ingredients: (a) at least one type of fragrance component selected from the group consisting of an aliphatic or aromatic aldehyde having 5 to 16 carbon atoms and an aliphatic or aromatic alcohol having 5 to 16 carbon atoms, and (b) at least one type of compound different from component (a) and selected from the group consisting of an aliphatic or aromatic aldehyde, an aliphatic or aromatic alcohol, acetal and ester that produces synergistic antifungal effects in the presence of said fragrance component (a). The present antifungal fragrance composition demonstrates antifungal activity by adding a small amount of oils and fragrant chemical products that have a minimal effect on the scent of the fragrance composition.

Abstract: Ectoparasites, such as fleas, ticks, mites and lice, are removed from a human or animal host after applying a composition that causes the temperature of the treated area to become higher or lower than normal. In one embodiment, treatment is effected by applying a composition that releases heat when contacted with water. The elevated or decreased temperature immobilizes the parasites and facilitates their mechanical removal, such as by combing.

Abstract: Generally, the method for preventing or relieving discomfort in the ears arising from congestion and/or obstruction of in the eustachian tubes comprising or changes in middle ear pressure relative to atmospheric pressure arising from environmental conditions in an individual need of prevention or relief from discomfort in the ears comprises the steps of: 1) administering a solution of 1.5%-3.5% (preferably 2-3%) sodium chloride solution having a pH of about 6 to 7.8 (preferably 6.5-7.5) in an aqueous solution as a spray or mist into the nose, 2) minimizing discharge of the solution from the nose for at least 5 seconds, then 3) evacuating the nose under pressure.

Abstract: The invention relates to a transparent or translucent cosmetic emulsion comprising an aqueous phase, a fatty phase and a surfactant, the said fatty phase containing a miscible mixture of at least one cosmetic oil and of at least one volatile fluoro compound, the latter compound being present in a proportion such that the refractive index of the fatty phase is equal to ±0.05 of that of the aqueous phase. The invention also relates to the process for preparing the emulsion. Use of the emulsion in skincare, hair conditioning and antisun protection and/or artificial tanning.

Abstract: The compact hair spray product includes a pressure-tight and diffusion-proof container containing a hair spray concentrate and equipped with a fine-spray pump with a cylindrical region made of a material that resists swelling by organic solvents. The fine spray pump has a maximum pump lift of 0.12 mL and pilot pressure buildup. The hair spray concentrate has a viscosity that confers good sprayability and contains at least one hair-strengthening polymer, an alcoholic solvent for the hair-strengthening polymer, at least one organic solvent additive capable of reducing the viscosity of the concentrate and increasing the vapor pressure of the concentrate and optionally a drying-retarding solvent additive.

Abstract: A method of dispersing, in water vapor, an anti-infective therapeutic composition (10) into the air in a room (36), in order to treat or prevent transmission of upper respiratory infections, includes: adding to a reservoir of liquid water in a vaporizer (34), a therapeutic composition (10) containing one or more antibiotics (14), alcohol (16), an analgesic (18) and an expectorant (20); and vaporizing the therapeutic composition (10) into the air along with the water in the vaporizer reservoir for inhalation by persons in the room.

Abstract: The present invention relates to a cosmetic aerosol-pressurized composition for treating keratin substances, in particular the hair, comprising (a) a fluid comprising at least one fixing polymer and at least 5% by weight, relative to the total weight of the pressurized composition, of a non-volatile aryl silicone and (b) at least one propellant, as well as to a process for treating keratin substances using this composition.

Abstract: The present invention relates to a volatile, residue free peroxide antimicrobial composition, which can be applied as a penetrating and durable, fine aerosol, that has superior strength with respect to decontaminating buildings infected with bacteria, fungi, virus or fungal or bacterial spores. The present invention is also directed to a process for decontaminating large man made structures and the air contained in these.

Abstract: The aerosol hair spray composition contains a hair-setting polymer in a solvent/propellant system containing a C1 to C4 alcohol, water, a cosolvent selected from among acetone and methyl acetate or a mixture thereof, and aerosol propellants, particularly a combination of dimethyl ether and a fluorocarbon. The composition according to the invention makes it possible to produce low-cost, water-containing aerosol hair sprays with a reduced VOC content and at the same time to optimize their use properties.

Abstract: A pressure-liquefied propellant mixture for aerosols, comprising a fluorinated alkane, in particular 1,1,1,2-tetrafluoroethane and/or 1,1,1,2,3,3,3-heptafluoropropane, and carbon dioxide, makes possible an improvement of the wetting properties of pharmaceutically active compounds, with which the formulation problems existing with hydrofluoroalkanes in relation to suspension as well as solution aerosols can be overcome and thus improved medicinal aerosol formulations can be obtained. With the aid of carbon dioxide, it is also possible to specifically influence the pressure and thus the particle size distribution and also by displacement of oxygen from the hydrofluoroalkanes to improve the storage stability of oxidation-sensitive active compounds.

Abstract: Strong vapors from eucalyptus oil and tea tree oil are inhaled periodically to prevent the infection of the human respiratory system by pathogens that cause colds, influenza, pneumonia, and tuberculosis. Apparatus suitable for the periodic inhalation of strong vapors from eucalyptus oil and tea tree oil are provided.

Abstract: The present invention provides a composition for attracting scarabs. Liquid and solid formulations are provided, along with methods for their use, for controlling or eliminating scarabs, and/or protecting plants susceptible to scarab damage.

Abstract: A mixed micellar aerosol pharmaceutical formulation includes a micellar proteinic pharmaceutical agent, an alkali metal lauryl sulphate, at least three micelle forming compounds, a phenol and a propellant. The micelle forming compounds are selected from the group consisting of lecithin, hyaluronic acid, pharmaceutically acceptable salts of hyaluronic acid, glycolic acid, lactic acid, chamomile extract, cucumber extract, oleic acid, linoleic acid, linolenic acid, monoolein, monooleates, monolaurates, borage oil, evening of primrose oil, menthol, trihydroxy oxo cholanyl glycine and pharmaceutically acceptable salts thereof, glycerin, polyglycerin, lysine, polylysine, triolein, polyoxyethylene ethers and analogues thereof, polidocanol alkyl ethers and analogues thereof. The amount of each micelle forming compound is present in a concentration of from 1 to 20 wt./wt. % of the total formulation, and the total concentration of micelle forming compounds are less than 50 wt./wt. % of the formulation.

Abstract: The invention relates to a transparent or translucent cosmetic emulsion comprising an aqueous phase, a fatty phase and a surfactant, the said fatty phase containing a miscible mixture of at least one cosmetic oil and of at least one volatile fluoro compound, the latter compound being present in a proportion such that the refractive index of the fatty phase is equal to ±0.05 of that of the aqueous phase. The invention also relates to the process for preparing the emulsion. Use of the emulsion in skincare, hair conditioning and antisun protection and/or artificial tanning.

Abstract: The present invention relates to the use of a sex pheromone, E8,E10-dodecadien-1-ol, in combination with one or more behavioral antagonists or behavioral synergists for control of codling moth by mating disruption or attraction & killing.

Abstract: Compositions and lures are described which provide synthetic chemical attractants which function as highly effective attractants for male and female moths, primarily moths of the family Noctuidae. In one aspect, the attractants provide an effective attractant amount of vapor of 3-methyl-1-butanol, 3-methyl-1-pentanol or mixtures thereof. In another aspect, the attractants provide vapor blends of acetic acid and one or more compounds selected from the group consisting of 3-methyl-1-butanol, 3-methyl-2-butanol, and 3-methyl-1-pentanol. By attracting male and female moths to traps or baits, the chemical attractants provide a means for detecting, surveying, monitoring, and controlling the moths.

Abstract: The invention relates to aerosol devices comprising a container which contains, in a cosmetically acceptable medium, a multiblock polymer comprising at least one polyurethane and/or polyurea unit, these devices being suitable for obtaining an initial flow rate of aerosol composition of less than or equal to 0.75 gram per second. The invention is also directed towards a process for shaping or maintaining the hairstyle, comprising the use of these devices, as well as their use for the manufacture of a lacquer or an aerosol spray.

Abstract: A projectile can be used to administer pesticides such as one or more from the group consisting of 4-allylanisole, anisole, allylbenzene, 4-isopropylanisole, p-anisaldehyde, ethylbenzene, cumene, 4-methoxyacetophenone, 4-methylstyrene, 2-propylphenol, phenetole, and toluene, for scolytid infestation. Conifers, which are a target for scolytids, are protected by the application of the pesticides by use of a projectile containing the compound which explodes upon contact with the conifer thereby emitting the compound.

Abstract: The malodorant compositions provided by the invention are formed from ingredients comprised of at least a malodorant compound and a carrier liquid, the compositions having a toxicity category rating of at least III. Preferred malodorant compounds suitable for use in the compositions of this invention of include organic sulfur compounds, and the compositions may include an appropriate amount of an odor intensifier, e.g., skatole, to provide a malodorant composition having low toxicity while providing the olfactory stimuli desired. The combination of these compounds is particularly effective in producing a malodorous stimulus for use in a variety of settings where non-lethal weapons are employed, all without permanently damaging the targeted subject or the surrounding environment. Non-lethal weapon systems for delivering to target the malodorant compositions of this invention, and associated methods of use of the compositions of this invention, are also described.

Abstract: Compositions and lures are described which provide synthetic chemical attractants which function as highly effective attractants for male and female moths, primarily moths of the family Noctuidae. In one aspect, the attractants provide an effective attractant amount of vapor of 3-methyl-1-butanol, 3-methyl-1-pentanol or mixtures thereof. In another aspect, the attractants provide vapor blends of acetic acid and one or more compounds selected from the group consisting of 3-methyl-1-butanol, 3-methyl-2-butanol, and 3-methyl-1-pentanol. By attracting male and female moths to traps or baits, the chemical attractants provide a means for detecting, surveying, monitoring, and controlling the moths.

Abstract: This invention relates to aerosol formulations of use in the administration of medicaments by inhalation. In particular, the formulations comprise (a) 1,1,1,2-tetrafluoroethane or 1,1,1,2,3,3,3-heptafluoro-n-propane or mixtures thereof as propellant, (b) 1,1,2,2,3-pentafluoropropane as co-propellant, and (c) particulate medicament. A method of treating respiratory disorders which comprises administration by inhalation of an effective amount of the pharmaceutical aerosol formulation is also described, as well as is a canister which is suitable for delivering the pharmaceutical aerosol formulation.

Abstract: The present invention relates to hair styling compositions and in particular to hair spray compositions. These compositions comprise a silicone containing adhesive copolymer, having a weight average molecular weight from about 10,000 to about 5,000,000, and a solvent for said copolymer selected from the group consisting of water, ethanol, n-propanol, isopropanol, and mixtures thereof. The spray compositions, when dried, have a cohesive strength of greater than about 0.5 kgf/mm.sup.2, a total energy absorption per unit volume of greater than about 0.55 kgfmm/mm.sup.3 and , preferably an impact strength of greater than about 7000 ergs. The hairspray embodiments of the present invention preferably provide improved removeability from hair as defined by a hair stiffness value of from 0 to about 3.5 (0 to 4 scale) and a hair flaking value of from 0 to about 3.5 (0 to 4 scale) as determined by the removeability methodology defined herein.

Abstract: The invention relates to fly attractant compositions that comprise at least one volatile short chain carboxylic acid, at least one organic sulfide and at least one nitrogen heterocycle. In a preferred embodiment the composition additionally comprises at least one ammonia-releasing compound. In a particularly preferred example, the composition is preparable by combining, for example, the carboxylic acid, the organic sulfide and the nitrogen heterocycle. The invention also relates to an insect trap comprising a means for retaining flies and an insect attractant composition of this invention. The trap is useful in commercial, residential and livestock facilities.

Abstract: Solid composition including a gum material and an tea tree oil and optionally another essential oil wherein the solid composition releases vapor containing the essential oil when exposed to an effective flow of gas. A method of diffusing tea tree oil into the atmosphere and a method of disinfecting air conditioning systems are also provided.

Abstract: Wicks or pads for use in vitaminized air fresheners and room deodorizer devices are disclosed, which permit devices occupants to directly receive and enjoy the benefits of vitamins with little or no effort intra-nasally as they breath the released volatile compositions. A method for the continuous release of a vitamin containing composition for the delivery of discrete droplets intra nasally absorbed vitamins such as, but not limited to A, C, and D is also disclosed.

Abstract: This invention relates to an aerosol hair spray formulation containing 0.5 to 15 weight percent of a water-dispersible or water-dissipatible, linear sulfopolyester having a Tg of 40.degree. C. to 50.degree. C. and an inherent viscosity of 0.24 to 0.60 dl/g which contains repeat units from 20 to 26 mole percent dimethyl-5-sodiosulfoisophthalate and 74 to 80 mole percent isophthalic acid, based on 100 mole percent dicarboxylic acid; 10 to 30 mole percent 1,4-cyclohexanedimethanol and 70 to 90 percent diethylene glycol, based on 100 mole percent diol; and up to 60 weight percent of an alcohol. The aerosol hair spray formulations are clear, have improved dry time and curl retention, and exhibit less than 20 NTU's, which is a measure of turbidity, even at high concentrations of alcohol.

Abstract: This invention is directed to a novel effervescing foaming bath shape or solid composition. More particularly, this invention pertains to a novel effervescing or foaming bath ball composition which has rapid mixing and production time, and antiseptic and skin conditioning properties. A bath shape or sold formulation comprising: (a) between 40 to 90% by weight of sodium bicarbonate; (b) between 5 to 50% by weight of organic acid; and (c) between 0.5 to 15% weight of alcohol. The formulation can also include (d) between 0.5 to 10% of vegetable oil; (e) between about 0.01 to 0.1 % weight of FD&C certified color to provide a pleasing color to the formulation; (f) between about 0.01 to 10% weight of fragrance to provide an appealing aroma to the composition, and a surfactant.

Abstract: The invention relates to the use as sole or additional foaming agent in aqueous compositions for treating the skin or the hair, which are packaged in an aerosol device and are capable of forming a foam after expansion into the air, of a terpolymer consisting of 25 to 90% of vinyl lactam, of 1 to 55% of unsaturated carboxylic acid and of 1 to 20% of alkyl acrylate or methacrylate containing at least 6 carbon atoms, and to cosmetic or dermatological compositions packaged as an aerosol and forming a foam in the air, containing the terpolymer.

Abstract: Vitaminized air fresheners and room deodorizers are disclosed which permit occupants to directly receive and enjoy the benefits of vitamins with little or no effort intra-nasally. A method for the continuous release of a vitamin containing composition for the delivery of discrete droplets intra nasally absorbed vitamins such as, but not limited to A, C, and D is also disclosed.

Abstract: This invention relates to an aerosol hair spray formulation containing 0.5 to 15 weight percent of a water-dispersible or water-dissipatible, linear sulfopolyester having a Tg of 40.degree. C. to 50.degree. C. and an inherent viscosity of 0.24 to 0.60 dl/g which contains repeat units from 20 to 26 mole percent dimethyl-5-sodiosulfoisophthalate and 74 to 80 mole percent isophthalic acid, based on 100 mole percent dicarboxylic acid; 10 to 30 mole percent 1,4-cyclohexanedimethanol and 70 to 90 mole percent diethylene glycol, based on 100 mole percent diol; and up to 60 weight percent of an alcohol. The aerosol hair spray formulations are clear, have improved dry time and curl retention, and exhibit less than 20 NTU's, which is a measure of turbidity, even at high concentrations of alcohol.

Abstract: A hairspray composition is provided with improved combability, spray efficiency and anti-foaming properties. The hairspray includes a film-forming resin, a carrier such as ethanol and a small level of a propoxylated non-ethoxylated silicone copolyol.

Abstract: The present invention provides an aerosol hairspray lacquer containing a film forming resin, plasticizing agent, water and dimethylether.

Abstract: The present invention provides a method for altering a person's perception of a confined or open space by administering an odorant substance to the person.

Abstract: An innovative-type hair spray concentrate of defined Brookfield viscosity and solids content which is capable of delivering reduced VOC spray particles of acceptable quality under the Innovative Product Clause Regulations in combination with a suitable restricter valve and actuator system. The concentrate includes a fixative which is the half-ester of a copolymer of maleic anhydride and methyl vinyl ether having a weight average molecular weight of about 40,000 to about 70,000, which provides advantageous physical and use performance properties.

Abstract: The composition contains as the active substance an inhibitor of proteinases selected from the group of aprotinin, a derivative thereof, or an aprotinin-like substance in the form of an aqueous solution or solid micronized particles or a size in the range of from 0.5 to 20 .mu.m. The aqueous solution contains the active substance in an amount of from 1500 to 10,000 KIU/ml.The composition is proposed for application in treatment and prophylaxis of predominantly viral respiratory diseases.

Abstract: An apparatus and process for administering minerals to the human body by mixing pre-selected particulated minerals with graphite and coal tar to form a bar (10a), vaporizing the bar (10a) to form a mineral rich vapor, and directing the vapor to a patient's skin using an enclosure (30).

Abstract: This invention relates to an aerosol hair spray formulation containing 0.5 to 15 weight percent of a water-dispersible or water-dissipatible, linear sulfopolyester having a Tg of 40.degree. C. to 50.degree. C. and an inherent viscosity of 0.24 to 0.60 dl/g which contains repeat units from 20 to 26 mole percent dimethyl-5-sodiosulfoisophthalate and 74 to 80 mole percent isophthalic acid, based on 100 mole percent dicarboxylic acid; 10 to 30 mole percent 1,4-cyclohexanedimethanol and 70 to 90 mole percent diethylene glycol, based on 100 mole percent diol; and up to 60 weight percent of an alcohol. The aerosol hair spray formulations are clear, have improved dry time and curl retention, and exhibit less than 20 NTU's, which is a measure of turbidity, even at high concentrations of alcohol.

Abstract: This invention relates to a pump hair spray formulation containing 0.5 to 15 weight percent of a water-dispersible or water-dissipatible, linear sulfopolyester having a Tg of 40.degree. C. to 50.degree. C. and an inherent viscosity of 0.24 to 0.60 dl/g which contains repeat units from 20 to 26 mole percent dimethyl-5-sodiosulfoisophthalate and 74 to 80 mole percent isophthalic acid, based on 100 mole percent dicarboxylic acid; 10 to 30 mole percent 1,4-cyclohexanedimethanol and 70 to 90 mole percent diethylene glycol, based on 100 mole percent diol; and up to 60 weight percent of an alcohol. The pump hair spray formulations are clear, have improved dry time and curl retention, and exhibit less than 20 NTU's, which is a measure of turbidity, even at alcohol concentrations of 60 weight percent.

Abstract: A clear hair spray formulation which exhibits less than 30 NTU's and contains a linear sulfopolyester and a water-soluble polymer wherein the formulation is in water or a water/alcohol mixture. The sulfopolyester has a glass transition temperature of 40.degree. C. to 60.degree. C. and contains repeat units from the reaction product of a dicarboxylic acid, a diol and a difunctional sulfomonomer. The difunctional sulfomonomer is present in an amount from 18.5 to 22.5 mole percent based on 100 mole percent dicarboxylic acid and 100 mole percent diol. The hair spray formulation may optionally contain a propellant.

Abstract: The invention refers to a hair spray containing a low proportion of volatile compounds and having improved spraying and setting properties comprisinga) about 5% to about 50% of at least one lower alcohol selected from the group of ethanol, n-propanol and (or) isopropyl alcohol;b) about 15% to about 70% by wt. water;c) about 1% to about 15% by wt. of at least one film-forming polymer;d) about 0.1% to about 3% by wt. of a water-dispersible silicone wax of the general formula I, ##STR1## wherein n and m may be identical or different and denote an integer between 10 and 20; which is either packede1) as an aerosol spray composition with dimethyl ether or a compressed gas selected from the group of di-nitrogen oxide, air, nitrogen and (or) carbon dioxide as propellent, ore2) as a manually operated pump spray.

Abstract: An aerosol system for dispensing a hair lacquer having a flammability classification less than or equal to 4 according to the Roth apparatus comprises, in combination, an aerosol recipient provided with a value equipped with a dispenser wherein the valve and dispenser have orifices such that the initial outflow of the hair lacquer is between 0.5 and 0.7 g/s. The aerosol recipient contains a hair lacquer composition consisting of 12 to 25% by weight of water, 10 to 26% by weight of an alcoholic phase selected from the group consisting of ethanol, isopropanol and mixtures thereof, and 49 to 78% by weight of dimethyl ether, the alcoholic phase containing from 3 to 5% by weight, compared to the total weight of the composition, of a synthetic film-forming resin.

Abstract: The invention is concerned with silicone-based skin care products which are applied to the skin as aerosols and form a clear gel on the skin. The skin care products comprise 20-70% w/w of a silicone based water-in-oil microemulsion and 30-80% w/w of a volatile diluent. Preferably the microemulsion has a viscosity of between 1000 and 10,000 mPas.

Abstract: This invention relates to a 0.5 to 7 wt. % solids hair fixative composition having superior moisture resistant hold and minimal tack duration which provides a stiff film on artificial or human hair and superior hair combability, which composition essentially contains a resin mixture of (a) a terpolymer derived from about 17 to about 30 wt. % N-vinyl pyrrolidone, from about 60 to about 80 wt. % N-vinyl caprolactam and from about 3 to about 6 wt. % di-C.sub.1 -C.sub.4 alkyl amino-C.sub.1 -C.sub.4 alkyl-acrylate or methacrylate having a number average molecular weight of between about 20,000 and about 200,000 and (b) a N-vinyl pyrrolidone/vinyl acetate copolymer having a number average molecular weight of between about 10,000 and about 100,000; combined in a weight ratio of 1.4-6:1 (a) to (b).

Abstract: A low volatile organic compounds hair spray microemulsion in the form of a stable, clear, single phase system in which the particles therein have a diameter of less than 1 micron, consisting essentially of, by weight,(a) an ethyl half-ester of a copolymer of maleic anhydride and an alkyl vinyl ether in an amount of less than 20%, optionally neutralized up to 20 mole %,(b) an ethoxylated glycerol fatty acid ester as the surfactant having a hydrophobic-lipophilic balance of 10-18, in an amount of at least 0.1%,(c) ethanol in an amount of 55% or less, and(d) water to 100%.