The Compound Contains Plural Peptide Linkages, I.e., Compound Formed From Amino Acids, Natural Or Synthetic, By Reaction Of A Carboxyl Group Of One Such Amino Acid With An Amino Group Of Another Same Or Different Such Amino Acid Patents (Class 516/103)
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Patent number: 10532385Abstract: Composition to aid in the sequestration and/or disposal of unused human or animal pharmaceutical drug or medication. The composition comprises a disposal composition material that contains a gelling or massing agent and optionally other components, and can be in the form of pellets, beads, beadlets, granules, or the like. The disposal composition material can be incorporated into a sachet or other disposal container or its cap to prevent the use of the medicament or the removal/extraction of active agent(s) from a pharmaceutical dosage form intended for disposal, to an appreciable extent and/or rate. With in the disposal agent, or fill material there may also be additional ingredients to promote mixing, sequestration or destruction of the active agent. The disposal composition is contained in a sachet and dispensed with a medicament for use when the patient has finished with the medication and there is material left over for disposal.Type: GrantFiled: June 29, 2017Date of Patent: January 14, 2020Assignee: DisposeRx, Inc.Inventors: Marcus Schestopol, Donald Treacy, Edward M. Rudnic, Beth A. Burnside, John W. Holaday
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Patent number: 10471173Abstract: Provided is a conformable composition for skin application having good formability into a predetermined shape, good conformability to skin, and shape retention after the contact with water such as excretion without loss of its shape. The conformable composition for skin application includes a reinforcing component, a rubber adhesive component, and a hydrophilic polymer compound, or the conformable composition for skin application at least includes 1 to 20 wt % a reinforcing component, 40 to 90 wt % a rubber adhesive component, and 2 to 40 wt % a hydrophilic polymer compound.Type: GrantFiled: May 20, 2015Date of Patent: November 12, 2019Assignee: ALCARE CO., LTD.Inventor: Toshihide Misawa
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Publication number: 20150047532Abstract: A method for solubilizing recombinant spider silk proteins in an aqueous solutions, where the method includes mixing recombinant spider silk proteins with water to form a mixture and heating the mixture in a closed vessel to form a solution.Type: ApplicationFiled: August 13, 2014Publication date: February 19, 2015Inventors: Randolph V. Lewis, Justin A. Jones
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Patent number: 8956656Abstract: The present invention relates to a method for producing particles of a compound of interest. In a method according to the invention a solution is provided of the compound of interest in a solvent. This solution is thickened or gelled and particles are formed. The invention further relates to a particle that is obtainable by the invention.Type: GrantFiled: November 22, 2005Date of Patent: February 17, 2015Assignee: Nano Fiber Matrices B.V.Inventors: Arianna Friggeri, Kjeld Jacobus Cornelis van Bommel, George Thomas Robillard
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Patent number: 8716248Abstract: A hydrogel that includes an aqueous solution or an alcohol aqueous solution, and a hydrogelator containing a lipid peptide represented by Formula (1), or a pharmaceutically usable salt thereof. In Formula (1), R1 represents an aliphatic group having 9 to 21 carbon atoms; R2, R3, and R4 independently represent a hydrogen atom, an alkyl group having 1 to 4 carbon atoms that optionally has a branched chain having 1 or 2 carbon atoms, a phenylmethyl group, or a —(CH2)n—X group, and at least one of R2, R3, and R4 represents a —(CH2)n—X group; n represents an integer from 1 to 4; and X represents an amino group, a guanidino group, a —CONH2 group, or a 5-membered ring, a 6-membered ring or a fused heterocyclic ring composed of a 5-membered ring and a 6-membered ring that optionally has 1 to 3 nitrogen atoms.Type: GrantFiled: March 4, 2013Date of Patent: May 6, 2014Assignees: Nissan Chemical Industries, Ltd., Kyushu UniversityInventors: Nobuhide Miyachi, Takehisa Iwama, Masahiro Gotoh, Tatsuo Maruyama, Daisuke Koda
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Publication number: 20130203687Abstract: A hydrogel that includes an aqueous solution or an alcohol aqueous solution, and a hydrogelator containing a lipid peptide represented by Formula (1), or a pharmaceutically usable salt thereof. In Formula (1), R1 represents an aliphatic group having 9 to 21 carbon atoms; R2, R3, and R4 independently represent a hydrogen atom, an alkyl group having 1 to 4 carbon atoms that optionally has a branched chain having 1 or 2 carbon atoms, a phenylmethyl group, or a —(CH2)n—X group, and at least one of R2, R3, and R4 represents a —(CH2)n—X group; n represents an integer from 1 to 4; and X represents an amino group, a guanidino group, a —CONH2 group, or a 5-membered ring, a 6-membered ring or a fused heterocyclic ring composed of a 5-membered ring and a 6-membered ring that optionally has 1 to 3 nitrogen atoms.Type: ApplicationFiled: March 4, 2013Publication date: August 8, 2013Applicants: KYUSHU UNIVERSITY, NISSAN CHEMICAL INDUSTRIES, LTD.Inventors: NISSAN CHEMICAL INDUSTRIES, LTD., KYUSHU UNIVERSITY
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Patent number: 8026289Abstract: A fluorinated polyoxyalkylene glycol diamide surfactant of formula 1 B—X—COCH2O—[—CpH2pO—]n—CH2CO—X—Ra??(1) wherein B is M or Ra, M is an ionizable hydrogen, ammonium, alkali metal, or alkaline earth metal, p is from about 2 to about 4, n is from about 5 about 43, each X is independently NR, SCH2CH2NR, SO2NRCH2CH2NR, or SO2CH2CH2NR; R is hydrogen, or a linear or branched alkyl group CbH(2b+1) wherein b is 1 to about 18, Ra is Rf(CH2CF2)d—(CgH2g)—; Rf(OCF2CF2)r—(CgH2g)—; RfOY—; Rf(CH2)h[(CF2CF2)i(CH2CH2)j]k—; Rf(CgH2g)—; or H(CcF2c)—(CgH2g)—; Y is CFHCF2O(CwH2w)—; or CF(CF3)CONH—(CgH2g)—; and each Rf is independently CcF(2c+1) wherein c is 1 to about 6.Type: GrantFiled: October 21, 2008Date of Patent: September 27, 2011Assignee: E.I. du Pont de Nemours and CompanyInventors: Peter Michael Murphy, Anilkumar Raghavanpillai
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Patent number: 8008357Abstract: In the process of producing a porous body containing a fibrous apatite/collagen composite by gelating a dispersion comprising the fibrous apatite/collagen composite, collagen and water, freeze-drying the resultant gel to form a porous body, and cross-linking collagen in the porous body, a method for controlling the average pore diameter of the porous body by the solidification time of the gel in the freezing step.Type: GrantFiled: March 23, 2005Date of Patent: August 30, 2011Assignees: Hoya Corporation, National Institute for Materials ScienceInventors: Daisuke Shoji, Katsumi Kawamura, Takehiko Nakajima, Junzo Tanaka, Masanori Kikuchi, Toshiyuki Ikoma, Naomi Mochizuki
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Patent number: 7863412Abstract: This invention provides a mixing method by which a mixing object can be uniformly mixed into a gelled assembly within a short time period. The method for mixing a mixing object into a gelled assembly comprises freezing the gelled assembly; melting the frozen assembly to obtain a sol; mixing the resultant sol and the mixing object; and reconstituting the gelled assembly from the sol into which the mixing object has been mixed.Type: GrantFiled: February 15, 2010Date of Patent: January 4, 2011Assignee: Menicon Co., Ltd.Inventors: Koji Uesugi, Yusuke Nagai, Hidenori Yokoi
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Patent number: 7678880Abstract: A molecular-oriented polymer gel and its cast film obtained by self-assembly of a self-organizable amphiphilic compound and a monomer interacting with the amphiphilic compound, and then polymerizing the monomer, and their production methods.Type: GrantFiled: August 7, 2003Date of Patent: March 16, 2010Assignees: Honda Giken Kogyo Kabushiki KaishaInventors: Nobuo Kimizuka, Kazuhiro Kagawa, Takuya Nakashima
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Patent number: 7645805Abstract: The invention relates to a novel class of gelling agents, to a process of preparing said agents, to the use of said agents to prepare gels, and to the gels thus obtained. A gelling agent or thickener according to the invention comprises a core which is functionalized with three amino acid derived groups by means of an amide or urea linkage. It may be used to gelate or thicken numerous solvents.Type: GrantFiled: May 22, 2003Date of Patent: January 12, 2010Assignee: Applied Nanosystems, B.V.Inventors: Kjeld Jacobus Cornelis van Bommel, Johannes Henricus van Esch, Maaike de Loos, André Heeres, Bernard Lucas Feringa
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Publication number: 20090215619Abstract: Absorbent hydrogels are formed from soy protein isolate. More specifically, an absorbent hydrogel is formed by contacting soy protein isolate with urea to produce solubilized soy protein isolate which is combined with 2-mercaptoethanol to form a first mixture. The first mixture is heated and combined with a polymerizable monomer and ammonium persulfate to form a second mixture. The second mixture is then heated, followed by removal of the hydrogel from the second mixture. Optionally, the as-formed hydrogel may be subjected to a washing process to extract non-reactant components from the gel and then dried.Type: ApplicationFiled: February 23, 2009Publication date: August 27, 2009Applicant: BATTELLE MEMORIAL INSTITUTEInventors: Herman P. Benecke, Bhima R. Vijayendran, Kevin B. Spahr
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Publication number: 20080234396Abstract: In the process of producing a porous body containing a fibrous apatite/collagen composite by gelating a dispersion comprising said fibrous apatite/collagen composite, collagen and water, freeze-drying the resultant gel to form a porous body, and cross-linking collagen in said porous body, a method for controlling the average pore diameter of said porous body by the solidification time of said gel in said freezing step.Type: ApplicationFiled: March 23, 2005Publication date: September 25, 2008Applicants: PENTAX CORPORATION, NATIONAL INSUTITUTE FOR MATERIALS SCIENCEInventors: Daisuke Shoji, Katsumi Kawamura, Takehiko Nakajima, Junzo Tanaka, Masanori Kikuchi, Toshiyuki Ikoma, Naomi Mochizuki
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Patent number: 7105580Abstract: In one aspect the present invention provides biodegradable, porous structures that each include a structural framework, wherein the structural framework includes: (a) a solidified mixture of polymer molecules and amino acid molecules, wherein at least some of the amino acid molecules are linked to other amino acid molecules within the framework; and (b) a multiplicity of interconnected spaces defined by the structural framework. In some embodiments, the porous structures of the invention are adapted to physically support the growth of living cells in vitro or in vivo, and can be used to grow living tissue and/or living organs. The present invention also provide methods for making the biodegradable, porous structures of the invention.Type: GrantFiled: December 5, 2002Date of Patent: September 12, 2006Assignee: University of WashingtonInventors: Prabha D. Nair, Buddy D. Ratner, Viola Vogel, Robert M. Nerem
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Patent number: 6576679Abstract: A hydrogel formed by adding an anion having a molecular weight of 90 or more to an aqueous dispersion of a cationic amphiphile comprising a linear or branched alkyl group having 10 or less carbon atoms in a hydrophobic moiety. The hydrogel has a network having a bilayer-membrane, nano-fiber structure and undergoes a reversible gel-sol transformation.Type: GrantFiled: September 18, 2001Date of Patent: June 10, 2003Assignees: Honda Giken Kogyo Kabushiki Kaisha, Nobuo KimizukaInventors: Nobuo Kimizuka, Takuya Nakashima, Kazuhiro Kagawa
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Patent number: 6420466Abstract: The invention relates to a process for preparing a solution that is active as a thixotropic agent and contains urea urethanes, in which monohydroxyl compounds are reacted with an excess of toluene diisocyanate, the unreacted portion of the toluene diisocyanate is removed from the reaction mixture and the monosiocyanate adduct obtained is further reacted with diarines in the presence of a lithium salt to form urea urethanes. The invention also relates to the use of the solution for imparting thixotropic properties to coating compounds.Type: GrantFiled: April 25, 2000Date of Patent: July 16, 2002Assignee: BYK-Chemie GmbHInventors: Karlheinz Haubennestel, Ulrich Orth
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Publication number: 20020091165Abstract: The present invention is a biodegradable, reversibly-swellable, polyvalent cation-binding, protein hydrogel which comprises an acylated protein matrix in which the acylated protein matrix is crosslinked with a bifunctional crosslinking reagent, and treated with a polar organic solvent, and a method of making the same.Type: ApplicationFiled: October 29, 2001Publication date: July 11, 2002Inventor: Srinivasan Damodaran
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Patent number: 6310105Abstract: The present invention is a biodegradable, reversibly-swellable, polyvalent cation-binding, protein hydrogel which comprises an acylated protein matrix in which the acylated protein matrix is crosslinked with a bifunctional crosslinking reagent, and treated with a polar organic solvent, and a method of making the same.Type: GrantFiled: February 15, 2000Date of Patent: October 30, 2001Assignee: Wisconsin Alumni Research FoundationInventor: Srinivasan Damodaran
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Patent number: 6228895Abstract: This invention relates to compositions, paper, thermoplastic sheets, and medical paper containing cellulose ester alkylpolyglycoside (APG) or a mixture of APG and polyether glycol, and, optionally, cellulose. The process of incorporating APG or a mixture of APG and polyether glycol in paper composed of cellulose ester fibers and cellulose fibers and to calendaring of such paper is also disclosed.Type: GrantFiled: November 30, 1998Date of Patent: May 8, 2001Assignee: Eastman Chemical CompanyInventors: Charles Michael Buchanan, Eric Eugene Ellery, Matthew Davie Wood
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Patent number: 5977190Abstract: A process of washing an emulsion such as a silver halide emulsion which contains a hydrophilic colloid comprises deionizing the emulsion and coagulating the emulsion with an anionic polymer and separating the coagulum from the supernatant and resuspending the coagulum with hydrophilic colloid, water and a base.Type: GrantFiled: January 14, 1998Date of Patent: November 2, 1999Assignee: Eastman Kodak CompanyInventors: Lloyd A. Lobo, Kenneth B. Quinn