Abstract: The present invention relates to a process for the production of hyaluronic acid (HA) derivatives. In particular, the process relates to multiple cross-linked hyaluronic acid derivatives, to navel cross-linked derivatives so obtained, and to products containing them and their uses in cosmetic, medical and pharmaceutical applications.

Abstract: The present invention is directed to enantioselective polyelectrolyte complex films. Further, said films may be free or isolated membranes, or coatings on substrates such a porous substrates, capillary tubes, chromatographic packing material, and monolithic stationary phases and used to separate chiral compounds. The present invention is also directed to a method for forming such enantioselective polyelectrolyte complex films.

Abstract: The present invention relates to the use of a pigment form or pigment concentrate comprising of an organic pigment, and optionally an inorganic filler and/or an organic additive for coloring of seeds. Seeds colored by the dry pigment forms or pigment concentrates show an homogeneous color and in some cases growth promotion effects.

Abstract: A hyaluronic acid gel composition comprising hyaluronic acid and a polymer, which is substantially unmodified with a chemical cross-linking agent or a chemical modifying agent and which has a percentage dissolution of hyaluronic acid of 50% or lower in 12 hours in a neutral aqueous solution of 37° C.

Abstract: A plastic material made from a polymer blend, is characterized in that said material contains at least one lignin-based natural polymer, in particular based on alkali lignin produced during the extraction of cellulose, and at least one other synthetic and/or natural polymer which increases the impact resistance, proteins excluded. The inventive plastic material has excellent characteristics. It is biodegradable due to the natural polymer content and has, to a considerable extent, an ecologically neutral CO2 balance. The polymer blend can be used advantageously in place of wood or wood materials.

Abstract: An aqueous emulsion of a resin which includes as an emulsifier at least one compound of the formula (I): R1—CO—NR2R3 wherein R1 is a polyunsaturated hydrocarbyl group; R2 is a polyhydroxy hydrocarbyl radical; and R3 is hydrogen, a hydrocarbyl, particularly alkyl, group, a hydroxy or hydrocarboxyloxy substituted hydrocarbyl, particularly hydroxy or alkoxy substituted alkyl, or is a group as defined for R2. The resin is preferably an alkyd resin, and the emulsions are particularly useful for incorporating into paints.

Abstract: A polymeric composition comprising a filler melt-dispersed in a matrix comprising, a destructurized starch component; a synthetic thermoplastic polymeric component selected from the group consisting of polyvinylalcohol, polyvinyl acetate, thermoplastic polyesters and graft copolymers of polysaccharides; and a fluidizing agent selected from the group consisting of C12-C22 fatty acids, C12-C22 fatty alcohols, esters and amides of said fatty acids, polyolefin waxes, polyglycol ethers of alditols, polyglycerols esterified with C12-C22 fatty acids, and mixtures thereof, wherein said filler is a mixture of an inorganic filler and a filler of organic nature, wherein the organic filler is present in an amount from 5% to 70% by weight.

Abstract: A plasticized composition comprising 40 to 82 percent cellulose nitrate, having nitrogen content of less than 12.6% relative to the weight of said cellulose nitrate, and 18 to 60 percent formylated polyurethane, said percent, both occurrences, being relative to the weight of the composition, is disclosed. The plasticized composition is suitable for use in preparing paints.

Abstract: Water-borne paints containing reduced molecular weight polysaccharide derivatives that are resistant to enzyme hydrolysis. The water-borne paints are biostable, retaining at least about 80% of their initial viscosity 24 hours after they are inoculated with polysaccharide hydrolysis enzyme.

Abstract: Water-borne paints containing reduced molecular weight polysaccharide derivatives that are resistant to enzyme hydrolysis. The water-borne paints are biostable, retaining at least about 80% of their initial viscosity 24 hours after they are inoculated with polysaccharide hydrolysis enzyme. A process for making the biostable water-borne paints has the steps: a) treating precursor polysaccharide derivative with polysaccharide hydrolysis enzyme in aqueous medium for a time sufficient to obtain reduced molecular weight polysaccharide derivative; and b) mixing the reduced molecular weight polysaccharide derivative with an effective amount of at least one other water-borne paint ingredient to obtain a water-borne paint.

Abstract: A polymeric composition comprises a matrix including a starch component and at least one synthetic thermoplastics polymeric component in which a filler is dispersed, characterised in that the matrix includes a fluidising agent selected from the group consisting of C.sub.12 -C.sub.22 fatty acids, C.sub.12 -C.sub.22 fatty alcohols, esters and amides of the said fatty acids, poly and polyglycol ethers of alditols or polyglycerols esterified with the said fatty acids and their mixtures and the said filler comprises natural fillers of an organic nature dispersed in the matrix in quantities of from 5% to 70% by weight with reference to the total weight of the composition.

Abstract: An ionomer for an ion complex membrane useful for the separation of water-organic solvent by osmosis or low pressure osmosis as well as by pervaporation and a method for producing ion complex membrane therefrom are disclosed. The ionomer for producing ion complex membrane can be prepared by heat polymerization of an alkyl compound having pyridyl groups such as 1,3-di(4-pyridyl) propane at both terminal ends with a dihaloalkane compound such as dibromooctane and dichloroheptane having two halogen atoms at both terminal ends or with one or two halogen atoms affixed to intermediate carbon atoms in a polar solvent such as acrylonitrile. An ion complex membrane can be produced by preparing a membrane of a polycation or polyanion in a solution casting method and dipping the membrane in a solution of polycation or polyanion for 24 hours to give an ion complex membrane. This ion complex membrane may be a single membrane or composite membrane. Composite membrane includes a plain membrane and a hollow fiber membrane.

Abstract: A gel forming system comprising an aqueous mixture of a first component of at least one water-soluble polymer in an amount sufficient to increase the initial viscosity of the mixture and impart adhesivity properties thereto; a second component of a acid-containing polymer; a third component of an amino-containing polymer; and water. This system has a pH in the range of between about 5.5 and 8.5 and the second and third components are each present in sufficient amounts which, in combination, increase the cohesiveness of the mixture over time, such that the mixture can be initially combined in a relatively fluid state and subsequently forms a cohesive gel structure.

Abstract: A biomaterial with a thromboresistant surface and a method for forming same are provided. The thromboresistant surface is comprised of a distinct coating layer of a chitosan-based membrane and a biologically active material. The biologically active material is capable of converting the chitosan membrane coating from a highly thrombogenic to an essentially non-thrombogenic one. The biologically active material can be a polymeric substance, such as polyvinyl alcohol, forming a polymeric blend with the chitosan, or, can be a biological substance, such as serum albumin, embedded in or attached to the chitosan membrane which has been activated with a treatment of glutardialdehyde. The thromboresistant biomaterial is suitable for use in vascular grafts having an inside diameter of less than 6 millimeters.

Abstract: Carbohydrate substituted dibenzo[d,f][1,3,2]dioxaphosphepin compounds of formula I ##STR1## where A is a carbohydrate residue are effective stabilizers for polymers processed at elevated temperatures and subject to thermal or oxidative degradation.

Abstract: A gel-forming composition is used in a process for molding a ceramic composition. The gel-forming composition, such as agar, is improved with a gel-enhancing agent, e.g. polyethyleneimine. As a result, the gel-forming composition improves the ceramic molding process and/or the ceramic product formed therefrom.

Abstract: Carbohydrate substituted dibenzo[d,g][1,3,2]dioxaphosphocin compounds of formula I ##STR1## where A is a carbohydrate residue are effective stabilizers for polymers processed at elevated temperatures and subject to thermal or oxidative degradation.

Abstract: The hydrogel of the invention contains polyvinyl alcohol (a hydrogel support), and a high water-absorbent resin and/or a hydrophilic high molecular compound, which are capable of containing a large amount of water. The rate of evaporation of water from this hydrogel is slow. The hydrogel retains water for a long time and releases an active ingredient gradually. The hydrogel containing a pharmacologically active substance is useful as a pharmaceutical preparation.

Abstract: The invention disclosed is a hydrogel-forming wound dressing or skin coating material suitable for household and veterinary use, consisting substantially entirely of wound-compatible and skin-compatible ingredients and comprising a first hydrophilic polymer, selected from polymers or copolymers of acrylic acid, polymers or copolymers of methacrylic acid, polymers or copolymers of itaconic acid, polymers or copolymers of maleic acid and polymers or copolymers of 3-butene-1,2,3-tricarboxylic acid, or combinations thereof, a second hydrophilic polymer which is capable of interacting with the first polymer to produce, upon drying, a hydrogel of improved water resistance and film forming properties relative to the first polymer alone and water. This material is film forming and substantially transparent but capable of being made opaque.

Abstract: Hydrocolloid adhesive compositions are disclosed comprising a rubbery elastomeric base having dispersed therein hydrocolloid particles, at least some of which are polycationic hydrocolloid particles. The compositions have enhanced resistance to breakdown by body fluids and are especially useful as wound dressings.

Abstract: The invention disclosed is a hydrogel-forming wound dressing or skin coating material suitable for household and veterinary use, consisting substantially entirely of wound-compatible and skin-compatible ingredients and comprising a first hydrophilic polymer, selected from polymers or copolymers of acrylic acid, polymers or copolymers of methacrylic acid, polymers or copolymers of itaconic acid, polymers or copolymers of maleic acid and polymers or copolymers of 3-butene-1,2,3-tricarboxylic acid, or combinations thereof, a second hydrophilic polymer which is capable of interacting with the first polymer to produce, upon drying, a hydrogen of improved water resistance and film forming properties relative to the first polymer alone and water. This material is film forming and substantially transparent but capable of being made opaque.

Abstract: The present invention includes:(i) a method for making a coated particulate comprising the steps ofheating until liquid a polyolefin wax;fluidizing with a hot gas, additive particles selected from the group comprising an antioxidant, a processing stabilizer, an acid acceptor, and mixtures thereof;spraying the liquid polyolefin wax on the heated fluidized additive particles, andmaintaining the fluidized additive particles at a temperature which is sufficient to prevent the formation of fibers and adequate to form discrete substantially coated additive particles;(ii) a coated particulate made by the above process; and(iii) a process for providing in-reactor stabilization of a polyolefin during a polymerization reaction, using the coated additives prepared by the above described method.

Abstract: A seed colorant useful especially in coloring seeds to distinguish same from those to be used for foods is formed of an aqueous medium such as water, a dye and/or pigment of a desired hue, and a binder resin composed of the salt of chitosan and an organic acid. The seed colorant may additionally contain spherical resin particles.

Abstract: Percutaneous emboli are formed for therapeutic and/or corrective reasons by using a composition which includes crosslinked gells of hyaluronic acid (HA), hylan (HY) or mixed crosslinked gels of HA or HY with other materials, thrombin and cationic substances containing quaternary ammonium groups. Other optional materials include fillers and radio-opaque substances.

Abstract: The present invention relates to a liquid suspension of a high molecular weight, water-soluble polymer or water-soluble salt prepared by admixing and water-soluble polymer with a hydrocarbon carrier fluid and a suspending agent comprising an aqueous emulsion of a copolymer comprising a water-insoluble and substantially hydrocarbon-insoluble polymer consisting of particles having a dry weight average particle size of below 10 .mu.m and which is formed from monomers of which 80% to 100% are hydrophobic, 30 to 100% are polar and 0% to 20% are hydrophilic. More particularly, the copolymer comprises from about 80% to about 100% C.sub.1-30 alkyl methacrylate monomers and from about 0% to about 20% hydrophilic monomers. Preferably, the copolymer comprises 90% to 100% 2-ethylhexylacrylate and from about 0.5% to about 10% acrylic acid. The liquid suspension is capable of supporting about 5 pounds of water-soluble polymer per gallon of suspension.

Abstract: Heavy metal salts of hyaluronic acid have been prepared. In particular, this invention is directed to silver, gold, cerium and tungsten salts of hyaluronic acid. These heavy metal salts of hyaluronic acid are useful as antimicrobial agents. Gold hyaluronate may also be used to treat arthritis. This invention also concerns methods of making the silver salt of hyaluronic acid as well as compositions containing silver hyaluronate or gold hyaluronate. The invention also concerns composition containing heavy metal salts having radioactively labelled hyaluronate moieties.

Abstract: A flexibilizing additive compatible with a wide variety of polymeric vehicles is provided wherein the additive comprises the reaction product of (a) an aliphatic polyisocyanate; (b) at least one monofunctional alcohol containing an ether or carboxyl oxygen; and (c) at least one diol. The flexibilizing additive can be combined with a thermoplastic or thermosetting film-forming vehicle to provide improved coating compositions.

Abstract: Disclosed are cross-linked gels of hyaluronic acid, alone or mixed with other hydrophilic polymers and containing various substances or covalently bonded low molecular weight substances and processes for preparing them. These products are useful in numerous applications including cosmetic formulations and as drug delivery systems.

Abstract: Disclosed are cross-linked gels of hyaluronic acid, alone or mixed with other hydrophilic polymers and containing various substances or covalently bonded low molecular weight substances and processes for preparing them. These products are useful in numerous applications including cosmetic formulations and as drug delivery systems.

Abstract: Polymeric materials (and articles made therefrom) including polyurethanes, polyesters, polyolefins, polyamides, polysiloxanes, vinylic and acrylic polymers are rendered biocompatible by including with the polymeric material hyaluronic acid or a salt thereof. The hyaluronic acid may be coated onto the surface of the polymeric material, dispersed throughout the body of the polymeric material, or both. The hyaluronic acid on the surface of the polymeric material may optionally be cross-linked. The biocompatible polymeric materials are used in the making of various prosthetic devices including heart valves, intraocular lenses, vascular grafts, pacemaker leads and the like.

Abstract: Polymeric materials (and articles made therefrom) including polyurethanes, polyesters, polyolefins, polyamides, polysiloxanes, vinylic and acrylic polymers are rendered biocompatible by including with the polymeric material hyaluronic acid or a salt thereof. The hyaluronic acid may be coated onto the surface of the polymeric material, dispersed throughout the body of the polymeric material, or both. The hyaluronic acid on the surface of the polymeric material may optionally be cross-linked. The biocompatible polymeric materials are used in the making of various prosthetic devices including heart valves, intraocular lenses, vascular grafts, pacemaker leads and the like.

Abstract: Particulate resoles are produced by mixing phenol, formaldehyde and amine in an aqueous medium containing a protective colloid. The resoles exhibit improved cure rate and sinter resistance when an alkaline compound is added to the reaction mixture after particulate formation.

Abstract: Water-based paints exhibiting improved stability and application properties are obtained by adding to 100 gallons (379 liters) of paint from 1 to 7 pounds (0.45 to 3.2 kg) of Heteropolysaccharide S-156.

Abstract: An heteropolysaccharide known as Biopolymer PS 87 comprises glucose, galactose, mannose, glucuronic acid and fucose. Biopolymer PS 87 is pseudoplastic, has a consistency at 20.degree. C. of at least 150 poise and a yield stress value at 20.degree. C. of at least 30 dynes/cm.sup.2. Biopolymer PS 87 is synthesised by a strain of Bacillus polymyxa or a genetically similar micro-organism and has many domestic and industrial uses as a suspending agent or thickener.