Lactam Monomer, E.g., Vinyl Pyrrolidone, Etc. Patents (Class 525/326.9)
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Patent number: 9658189Abstract: An aqueous liquid medium for analyzing, purifying or separating species in an element having walls or for treating the walls of an element. The medium includes at least a polymer consisting of several polymeric segments. The polymer is of the irregular block-copolymer or irregular comb-like polymer type and has on the average at least three junction points between polymeric segments of different chemical or topological nature. The medium may be used in methods for analyzing, purifying or separating species and methods for treating an element to be contacted with a fluid and/or species contained in the fluid during preservation, transport, analysis, purification or separation of the fluid.Type: GrantFiled: May 2, 2016Date of Patent: May 23, 2017Assignees: Institute Curie, Centre National de la Recherche Scientifique (C.N.R.S)Inventors: Jean-Louis Viovy, Valessa Barbier
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Patent number: 9347915Abstract: An aqueous liquid medium for analyzing, purifying or separating species in an element having walls or for treating the walls of an element. The medium includes at least a polymer consisting of several polymeric segments. The polymer is of the irregular block-copolymer or irregular comb-like polymer type and has on the average at least three junction points between polymeric segments of different chemical or topological nature. The medium may be used in methods for analyzing, purifying or separating species and methods for treating an element to be contacted with a fluid and/or species contained in the fluid during preservation, transport, analysis, purification or separation of the fluid.Type: GrantFiled: February 11, 2015Date of Patent: May 24, 2016Assignees: Institute Curie, Centre National de la Recherche Scientifique (C.N.R.S)Inventors: Jean-Louis Viovy, Valessa Barbier
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Patent number: 9242437Abstract: A hot-melt pressure-sensitive adhesive (HMPSA) composition comprising (a) 25 to 50% of one or more styrene block copolymers SBS, SIS, SIBS, SEBS or SEPS; (b) 35 to 75% of one or more compatible tackifying resins that are liquid or have a softening temperature below 150° C.; and (c) 1 to 20% of one or more supramolecular polymers obtained by reaction between 1-(2-aminoethyl)-2-imidazolidone and a fatty acid composition comprising 51 to 100% of one or more dimers and/or trimers of fatty acids and 0 to 49% of one or more monomers of fatty acids. A multilayer system including the HMPSA, an adjacent printable support layer, made of paper or a polymer film, and a protective layer adjacent is also provided. The multilayer system may be used in a self-adhesive label.Type: GrantFiled: May 11, 2011Date of Patent: January 26, 2016Assignee: BOSTIK S.A.Inventors: David Goubard, Nicolas Sajot
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Patent number: 9066992Abstract: The present invention is directed to polymeric compositions comprising a biodegradable copolymer that possesses shape-memory properties and implantable devices (e.g., drug-delivery stents) formed of materials (e.g., a coating) containing such compositions. The polymeric compositions can also contain at least one non-fouling moiety, at least additional biocompatible polymer, at least one biobeneficial material, at least one bioactive agent, or a combination thereof. The polymeric compositions are formulated to possess good mechanical, physical and biological properties. Moreover, implantable devices formed of materials comprising such compositions can be delivered to the treatment site in a conveniently compressed size and then can expand to dimensions appropriate for their medical functions.Type: GrantFiled: May 28, 2013Date of Patent: June 30, 2015Assignee: Abbott Cardiovascular Systems Inc.Inventors: John J. Stankus, O. Mikael Trollsas, Michael H. Ngo
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Patent number: 8703875Abstract: The invention relates to novel crosslinkable copolymers which are obtainable by (a) copolymerizing at least two different hydrophilic monomers selected from the group consisting of N,N-dimethyl acrylamide (DMA), 2-hydroxyethyl acrylate (HEA), glycidyl methacrylate (GMA), N-vinylpyrrolidone (NVP), acrylic acid (AA) and a C1-C4-alkoxy polyethylene glycol(meth)acrylate having a weight average molecular weight of from 200 to 1500, and at least one crosslinker comprising two or more ethylenically unsaturated double bonds in the presence of a chain transfer agent having a functional group; and (b) reacting one or more functional groups of the resulting copolymer with an organic compound having an ethylenically unsaturated group.Type: GrantFiled: February 27, 2013Date of Patent: April 22, 2014Assignee: Novartis AGInventors: Frank Chang, Norberto Arturo Medina
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Publication number: 20140072526Abstract: The present invention relates to an adsorbate of a pharmaceutically compatible rasagiline salt comprising at least one pharmaceutically compatible adjuvant, wherein the at least one pharmaceutically compatible adjuvant is a water-soluble, organic solvent and the rasagiline salt is present in the adsorbate as an amorphous substance.Type: ApplicationFiled: September 3, 2013Publication date: March 13, 2014Applicant: RATIOPHARM GMBHInventors: Alexander Lehmann, Frank Muskulus, Julia Schulze-Nahrup
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Patent number: 8637589Abstract: In one aspect, the invention relates to silicone prepolymer compositions comprising a silicone prepolymer and a solvent. A soluble silicone prepolymer can be provided having increased average silicon content, thereby attaining a desired oxygen permeability. A solvent can be provided with a desired balance between hydrophilicity and hydrophobicity by selection and modification of the solvent molecular structure, resulting in molded polymer films and articles that exhibit minimal or nonexistent eye irritation and exhibit highly transparent products. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.Type: GrantFiled: December 7, 2010Date of Patent: January 28, 2014Assignees: Johnson & Johnson Vision Care, Inc., Toray IndustriesInventors: Kazuhiko Fujisawa, Mitsuru Yokota, Masataka Nakamura
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Patent number: 8586681Abstract: The invention provides methods for making copolymers and multi-arm block copolymers useful as drug delivery vehicles. The multi-arm block copolymers comprise a central core molecule, such as a residue of a polyol, and at least three copolymer arms covalently attached to the central core molecule, each copolymer arm comprising an inner hydrophobic polymer segment covalently attached to the central core molecule and an outer hydrophilic polymer segment covalently attached to the hydrophobic polymer segment, wherein the central core molecule and the hydrophobic polymer segment define a hydrophobic core region. The solubility of hydrophobic biologically active agents can be improved by entrapment within the hydrophobic core region of the block copolymer. The invention further includes pharmaceutical compositions including such block copolymers, pharmaceutical compositions, and methods of using the block copolymers as drug delivery vehicles.Type: GrantFiled: November 19, 2012Date of Patent: November 19, 2013Assignee: Nektar TherapeuticsInventor: Xuan Zhao
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Publication number: 20130280237Abstract: The invention generally relates to synthetic mimics of cell penetrating peptides. More particularly, the invention relates to certain novel monomers, oligomers and polymers (e.g., co-polymers) that are useful for the preparation of synthetic mimics of cell penetrating peptides, their compositions, preparations and use.Type: ApplicationFiled: June 24, 2011Publication date: October 24, 2013Applicant: University of MassachusettsInventors: Gregory N. Tew, Gregory J. Gabriel, Abhigyan Som, Arife Ozgul Tezgel
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Publication number: 20130261268Abstract: The present invention provides lactamic polymers containing an acetoacetate moiety. The lactamic polymers may be readily functionalized and the functionalized lactamic polymers may be further derivatized to provide a wide variety of useful polymers having desirable chemical and physical properties. The lactamic polymers of the present invention may be employed in a wide variety of compositions. Formula (I) wherein R1-R7, x, y, z, and n are described herein.Type: ApplicationFiled: October 11, 2011Publication date: October 3, 2013Applicant: ISP Investments IncInventors: David K. Hood, Karyn B. Visscher, Surya Kamin
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Publication number: 20130079265Abstract: The invention relates to a polyalkyl (meth) acrylate for improving lubricating oil properties, which comprises repetition units which are derived from (meth) acrylates having 6 to 22 carbon atoms in the alcohol residues, and repetition units which are derived from amine derivatives of an ethylenically unsaturated monomer. The invention further relates to methods for producing and using the present polyalkyl (meth) acrylate.Type: ApplicationFiled: June 27, 2011Publication date: March 28, 2013Applicant: Evonik Oil Additives GmbHInventors: Boris Eisenberg, Dieter Janssen, Ellen Suchert, Miriam Kathrin Stihulka, Lucas Voigt
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Patent number: 8404783Abstract: The invention relates to novel crosslinkable copolymers which are obtainable by (a) copolymerizing at least two different hydrophilic monomers selected from the group consisting of N,N-dimethyl acrylamide (DMA), 2-hydroxyethyl acrylate (HEA), glycidyl methacrylate (GMA), N-vinylpyrrolidone (NVP), acrylic acid (AA) and a C1-C4-alkoxy polyethylene glycol (meth)acrylate having a weight average molecular weight of from 200 to 1500, and at least one crosslinker comprising two or more ethylenically unsaturated double bonds in the presence of a chain transfer agent having a functional group; and (b) reacting one or more functional groups of the resulting copolymer with an organic compound having an ethylenically unsaturated group.Type: GrantFiled: July 10, 2007Date of Patent: March 26, 2013Assignee: Novartis AGInventors: Frank Chang, Norberto Arturo Medina
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Publication number: 20130072405Abstract: The present invention refers to the use of anionic water-soluble polymers being partially or totally neutralized with an organic counter-ion for oil filed application, especially tertiary oil recovery steps.Type: ApplicationFiled: January 26, 2011Publication date: March 21, 2013Inventors: Cédrick Favero, Nicolas Gaillard, Dennis Marroni
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Publication number: 20130053507Abstract: A hydrophobic cationic steroidal anti-microbial (ceragenin) compound forms an amphiphilic compound having a hydrophobic sterol face and a hydrophilic cationic face. The hydrophobic CSA also includes a hydrophobic substituent that gives the ceragenin compound a CLogP value of at least 6.5.Type: ApplicationFiled: July 20, 2012Publication date: February 28, 2013Inventor: Paul B. Savage
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Publication number: 20130004453Abstract: Non-natural oligomers have recently shown promise as functional analogues of lung surfactant proteins Band C (SP-B and SP-C), two helical and amphiphilic proteins that are clitical for normal respiration. The generation of non-natural mimics of SP-B and SP-C has previously been restlicted to step-by-step, sequence-specific synthesis, which results in discrete oligomers that are intended to manifest specific structural attributes. Presented herein an alternative approach to SP-R mimicry that is based on sequence-random copolymers containing cationic and lipophilic subunits. These materials, members of the nylon-3 family, arc prepared by ling-opening polymelization of 13-lactams. The best of the nylon-3 polymers display promising in vitro surfactant activities in a mixed lipid film. Pulsating bubble surfactometry data indicate that films containing the most surface-active polymers attain adsorptive and dynamic-cycling properties that surpass those of discrete peptides intended to mimic SP-B.Type: ApplicationFiled: March 17, 2011Publication date: January 3, 2013Inventors: Samuel H. Gellman, Shannon S. Stahl, Brendan P. Mowery, Annelise Barron, Michelle Dohm
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Patent number: 8338545Abstract: The invention provides methods for making copolymers and multi-arm block copolymers useful as drug delivery vehicles. The multi-arm block copolymers comprise a central core molecule, such as a residue of a polyol, and at least three copolymer arms covalently attached to the central core molecule, each copolymer arm comprising an inner hydrophobic polymer segment covalently attached to the central core molecule and an outer hydrophilic polymer segment covalently attached to the hydrophobic polymer segment, wherein the central core molecule and the hydrophobic polymer segment define a hydrophobic core region. The solubility of hydrophobic biologically active agents can be improved by entrapment within the hydrophobic core region of the block copolymer. The invention further includes pharmaceutical compositions including such block copolymers, pharmaceutical compositions, and methods of using the block copolymers as drug delivery vehicles.Type: GrantFiled: November 2, 2011Date of Patent: December 25, 2012Assignee: Nektar TherapeuticsInventor: Xuan Zhao
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Publication number: 20120317734Abstract: Described herein are beneficial hair color mixes comprising lightly- to moderately-crosslinked PVP. The color mix may be derived from one, two, or more parts, and the color mix exhibits satisfactory viscosity, stability, and formulation compatibility.Type: ApplicationFiled: February 17, 2012Publication date: December 20, 2012Applicant: ISP INVESTMENTS INC.Inventors: Jose Martinez-Santiago, Anand Ramchandra Mahadeshwar
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Patent number: 8277932Abstract: Membranes, methods of making membranes, and methods of separating gases using membranes are provided. The membranes can include at least one hydrophilic polymer, at least one cross-linking agent, at least one base, and at least one amino compound. The methods of separating gases using membranes can include contacting a gas stream containing at least one of CO2, H2S, and HCl with one side of a nonporous and at least one of CO2, H2S, and HCl selectively permeable membrane such that at least one of CO2, H2S, and HCl is selectively transported through the membrane.Type: GrantFiled: June 20, 2011Date of Patent: October 2, 2012Assignee: The Ohio State University Research FoundationInventor: W. S. Winston Ho
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Patent number: 8227555Abstract: The present invention is directed to conjugates of hydrolytically stabilized maleimide-functionalized water soluble polymers and to methods for making and utilizing such polymers and their precursors.Type: GrantFiled: December 23, 2011Date of Patent: July 24, 2012Assignee: Nektar TherapeuticsInventors: Antoni Kozlowski, Remy F. Gross, III, Samuel P. McManus
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Publication number: 20120157352Abstract: The invention relates to novel polymers derived from: (A) at least one N-vinyl amide-based unit and/or at least one acrylamide-based unit, and (B) at least one unit comprising: (i) at least one hydroxyl group, and/or (ii) at least one functional group convertible to a hydroxyl group wherein at least one group is converted to hydroxyl functionality in the final polymer product, wherein the polymer comprises at least one ester group. The polymers and compositions are used in oilfield applications, such as an inhibitor of gas hydrates and/or a kinetic inhibitor of gas hydrates. The polymer can assume alternating, block, and/or random configurations of the repeating units, with at least one ester group.Type: ApplicationFiled: March 25, 2010Publication date: June 21, 2012Applicant: ISP INVESTMENTS INC.Inventors: Osama M. Musa, Cuiyue Lei
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Publication number: 20120085931Abstract: Fluorescing gel formulations are disclosed for monitoring cleaning of a surface. The fluorescing gel formulations are stable, fluoresce under UV light, and do not leave a mark after drying and removal. The compositions include an oppositely charged complexing agent which is used in combination with an anionic or cationic optical brightener. In some embodiments, the compositions include a cationic optical brightener with no complexing agent.Type: ApplicationFiled: October 6, 2011Publication date: April 12, 2012Applicant: ECOLAB USA INC.Inventors: NICOLE BURNS, XIN SUN, THOMAS R. MOHS, JOSEPH R. WEGNER, MARK LEVITT, STEVEN E. LENTSCH
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Patent number: 8106131Abstract: The present invention is directed to hydrolytically stabilized maleimide-functionalized water soluble polymers and to methods for making and utilizing such polymers and their precursors.Type: GrantFiled: August 26, 2008Date of Patent: January 31, 2012Assignee: Nektar TherapeuticsInventors: Antoni Kozlowski, Remy F. Gross, III, Samuel P. McManus
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Publication number: 20120014874Abstract: Provided are a photosensitizer-metal nanoparticle charge complex and a composition for photodynamic therapy or diagnosis containing the same. The complex includes a metal nanoparticle, a photosensitizer charged with a first charge, and a linker bound to the metal nanoparticle and charged with a second charge having an opposite polarity to the first charge. During circulation in blood, the photosensitizer-metal nanoparticle charge complex is maintained in a complex type, and thus duration of a side effect of photosensitivity can be reduced. In a tumor tissue, the complex is specifically accumulated, but in a normal tissue, it is difficult for the complex to penetrate. Thus, the complex can selectively destroy the tumor tissue. Moreover, selective fluorescence in the tumor tissue can provide further improvement in accuracy of diagnosing a tumor using the complex.Type: ApplicationFiled: October 28, 2009Publication date: January 19, 2012Inventors: Yong-Doo Choi, Bo-seung Jang, JIn-Young Park, Jung-Im Lee, In-Hoo Kim
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Patent number: 8071692Abstract: The invention provides methods for making copolymers and multi-arm block copolymers useful as drug delivery vehicles. The multi-arm block copolymers comprise a central core molecule, such as a residue of a polyol, and at least three copolymer arms covalently attached to the central core molecule, each copolymer arm comprising an inner hydrophobic polymer segment covalently attached to the central core molecule and an outer hydrophilic polymer segment covalently attached to the hydrophobic polymer segment, wherein the central core molecule and the hydrophobic polymer segment define a hydrophobic core region. The solubility of hydrophobic biologically active agents can be improved by entrapment within the hydrophobic core region of the block copolymer. The invention further includes pharmaceutical compositions including such block copolymers, pharmaceutical compositions, and methods of using the block copolymers as drug delivery vehicles.Type: GrantFiled: August 7, 2009Date of Patent: December 6, 2011Assignee: Nektar TherapeuticsInventor: Xuan Zhao
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Patent number: 8044172Abstract: Cell-occlusive membrane, obtainable by reaction of at least two precursors in the presence of water. The first precursor A comprises a core and n chains each having a conjugated unsaturated group or a conjugated unsaturated bond, and the second precursor B comprises a core and m chains each having a thiol group, wherein m is greater than or equal to 2, n is greater than or equal to 2, and m+n is greater than or equal to 5. The reaction forms a three dimensional network with crosslinking-points. The adjacent crosslinking-points are connected by a chain having less than 600 atoms.Type: GrantFiled: October 15, 2009Date of Patent: October 25, 2011Assignee: Straumann Holding AGInventor: Aaldert Rens Molenberg
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Publication number: 20110250149Abstract: The present invention provides tiotropium bromide having a low degree of crystallinity. The present invention also provides a complex of tiotropium bromide and polyvinylpyrrolidone, processes for preparing it and pharmaceutical formulations including it.Type: ApplicationFiled: October 29, 2009Publication date: October 13, 2011Applicant: CIPLA LIMITEDInventors: Rajendra Narayanrao Kankan, Dharmaraj Ramachandra Rao, Maruti Ghagare
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Publication number: 20110166297Abstract: Molecularly imprinted smart polymers (MISPs) are provided herein, as well as novel monomers for preparing MISPs, and processes for preparing MISPs. The MISPs can be used applications such as, for example, detecting/absorbing or isolating biological and non-biological agents. The MISPs described herein comprise responsive monomeric units which undergo a physico-chemical change (e.g., a bond formation or cleavage) in response to an external change, such that the MISP selectively binds to a target molecule and releases a bound target molecule in response to the external change.Type: ApplicationFiled: September 9, 2009Publication date: July 7, 2011Applicant: Sailo Nanotechnologies Ltd.Inventors: Flavio Grynszpan, Eran Partouche, Vladimir Shkoulev, Alex Aizikovich, Sharon Gazal, Rachel Nakash-Ozeri, Isaac Zigelboim
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Patent number: 7968650Abstract: The present invention relates to compositions comprising a polymeric substrate comprising at least one volume excluding polymer. In one embodiment, the present invention provides polymeric articles that are capable of acting as osmotic drivers. The articles are capable of maintaining a desired water balance by moving water in or out of a substrate to maintain cation concentration equilibrium between the substrate and its environment.Type: GrantFiled: October 26, 2007Date of Patent: June 28, 2011Assignee: Johnson & Johnson Vision Care, Inc.Inventors: Brian J. Tighe, Muriel Nasso, Beverley Benning, Frank F. Molock, Jr.
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Patent number: 7968651Abstract: Provided are a conducting polymer film composition comprising a graft copolymer of a self-doped conducting polymer and an organic opto-electronic device comprising a conducting polymer film formed of the above-mentioned composition. In the graft copolymer, the conducting polymer and a polyacid are connected to each other via chemical binding. Therefore, the composition of the present invention can be used in organic opto-electronic devices with minimal or no dedoping occurring from heat generated inside the device. As a result, the present invention can improve efficiency and life-time of the organic opto-electronic device.Type: GrantFiled: May 2, 2008Date of Patent: June 28, 2011Assignee: Cheil Industries Inc.Inventors: Dal Ho Huh, Mi Young Chae, Tae Woo Lee, Woo Jin Bae, Eun Sil Han
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Patent number: 7935771Abstract: There is provided a polymer including a unit represented by Chemical Formula (1): wherein R represents -A1-SO2R1; R1w and R1x are each independently a halogen atom or a hydrogen atom; R1y is a CH3 group, a halogen atom or a hydrogen atom; A01 is a substituted or unsubstituted aromatic ring structure or a substituted or unsubstituted heterocyclic structure; A1 is a substituted or unsubstituted aliphatic hydrocarbon structure, a substituted or unsubstituted aromatic ring structure or a substituted or unsubstituted heterocyclic structure; R1 is OH, a halogen atom, ONa, OK or OR1a; R1a is a substituted or unsubstituted aliphatic hydrocarbon structure, a substituted or unsubstituted aromatic ring structure or a substituted or unsubstituted heterocyclic structure.Type: GrantFiled: November 10, 2006Date of Patent: May 3, 2011Assignee: Canon Kabushiki KaishaInventors: Tatsuki Fukui, Akiko Tominaga, Takashi Kenmoku, Masato Minami, Tetsuya Yano, Takeshi Ikeda, Atsushi Tani, Norikazu Fujimoto
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Patent number: 7910661Abstract: The present invention provides water-soluble, polymer derivatives having a thiol-selective terminus suitable for selective coupling to thiol groups, such as those contained in the cysteine residues of proteins.Type: GrantFiled: January 6, 2004Date of Patent: March 22, 2011Assignee: Nektar TherapeuticsInventors: Antoni Kozlowski, Remy F. Gross, III, Samuel P. McManus
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Patent number: 7897654Abstract: In one aspect, the invention relates to silicone prepolymer compositions comprising a silicone prepolymer and a solvent. A soluble silicone prepolymer can be provided having increased average silicon content, thereby attaining a desired oxygen permeability. A solvent can be provided with a desired balance between hydrophilicity and hydrophobicity by selection and modification of the solvent molecular structure, resulting in molded polymer films and articles that exhibit minimal or nonexistent eye irritation and exhibit highly transparent products. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.Type: GrantFiled: April 1, 2008Date of Patent: March 1, 2011Assignees: Johnson & Johnson Vision Care Inc., Toray Industries Inc.Inventors: Kazuhiko Fujisawa, Mitsuru Yokota, Masataka Nakamura
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Patent number: 7838600Abstract: The instant invention provides a two-step polymerization process for preparing amphiphilic poly(N-vinyl-2-pyrrolidone), (PVP)-block-polyester copolymers and other diblock and triblock copolymers consisting of PVP as one block. The block copolymers of the invention can be used as vehicles for drug delivery.Type: GrantFiled: September 16, 2008Date of Patent: November 23, 2010Assignees: Labopharm, Inc., Labopharm Europe Limited, Labopharm (Barbados) LimitedInventors: Laibin Luo, David Lessard, Sandra Gori, Maxime Ranger, Yuan Wang, Julie Lafreniere, Jean-Francois Meunier, Genevieve Bibeau, Frederic Lebrun, Lu Wei Liu
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Patent number: 7807750Abstract: A thermally-reactive polymer that forms a polymer-coupled reactive species upon heating is described and useful for forming coated surfaces. The polymer-coated surface has improved lubricity and passivity. A thermally-reactive quaternary amine-containing polymer was produced that provides passivity and anti-microbial activity.Type: GrantFiled: September 17, 2004Date of Patent: October 5, 2010Assignee: SurModics, Inc.Inventors: Kristin S. Taton, Patrick E. Guire
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Patent number: 7767756Abstract: The application describes materials derived from keratin proteins in combination with polymers, either as intimate mixtures with water soluble polymers, or as chemically bound copolymers. The keratin protein is a specific keratin protein fraction, and is preferably intact, s-sulfonated and from the intermediate filament protein family. The application also describes the process for production of these materials.Type: GrantFiled: September 13, 2004Date of Patent: August 3, 2010Assignee: Keraplast Technologies, Ltd.Inventors: Robert James Kelly, Mohammad Azam Ali, Alisa Dawn Roddick-Lanzilotta, Gillian Worth, Mohammad Mahbubul Hassan, John Robert McLaughlin, Alan John McKinnon
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Patent number: 7741427Abstract: The present invention relates to a cell-occlusive membrane, obtainable by reaction of at least two precursors in the presence of water. The first precursor A comprises a core and n chains each having a conjugated unsaturated group or a conjugated unsaturated bond, and the second precursor B comprises a core and m chains each having a thiol group, wherein m is greater than or equal to 2, n is greater than or equal to 2, and m+n is greater than or equal 5. The reaction forms a three dimensional network with crosslinking-points. The adjacent crosslinking-points are connected by a chain having less than 600 atoms.Type: GrantFiled: May 9, 2005Date of Patent: June 22, 2010Assignee: Straumann Holding AGInventor: Aaldert Rens Molenberg
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Patent number: 7659344Abstract: Disclosed is a composition, which may be melt extrudable, comprising polyvinylpyrrolidone-iodine complex in at least one polymer. Also disclosed is a process for preparing the composition or shaped articles, including films, made therefrom. The composition can be extruded, blown film extruded, or molded into films, fibers, tubing, and shaped articles thermoformed or molded shapes, including containers, usable, for instance, as catheters, in delivery systems for drugs and nutrients, specimen containers, or surgical devices.Type: GrantFiled: June 8, 2006Date of Patent: February 9, 2010Assignee: E. I. du Pont de Nemours and CompanyInventor: David C. Urian
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Publication number: 20090230053Abstract: Hydrophilic porous polymeric membranes with high permeabilities, and processes for the preparation thereof are disclosed. Membranes may be prepared by including a preferably hydrophilic cross-linkable component such as PVP (either by inclusion into the polymer dope prior to casting, or coating or quenching cast membranes); and treating the polymeric microfiltration or ultrafiltration membrane with a crosslinking agent to cross-link said cross-linkable component. Preferred cross-linking agents include Fenton's reagent.Type: ApplicationFiled: December 2, 2005Publication date: September 17, 2009Applicant: SIEMENS WATER TECHNOLOGIES CORP.Inventor: Daniel Mullette
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Patent number: 7589157Abstract: The invention provides methods for making copolymers and multi-arm block copolymers useful as drug delivery vehicles. The multi-arm block copolymers comprise a central core molecule, such as a residue of a polyol, and at least three copolymer arms covalently attached to the central core molecule, each copolymer arm comprising an inner hydrophobic polymer segment covalently attached to the central core molecule and an outer hydrophilic polymer segment covalently attached to the hydrophobic polymer segment, wherein the central core molecule and the hydrophobic polymer segment define a hydrophobic core region. The solubility of hydrophobic biologically active agents can be improved by entrapment within the hydrophobic core region of the block copolymer. The invention further includes pharmaceutical compositions including such block copolymers, pharmaceutical compositions, and methods of using the block copolymers as drug delivery vehicles.Type: GrantFiled: August 21, 2007Date of Patent: September 15, 2009Assignee: Nektar Therapeutics AL, CorporationInventor: Xuan Zhao
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Patent number: 7589139Abstract: There is disclosed a polyvinylpyrrolidone powder composition including polyvinylpyrrolidone having a K value of not lower than 60 and not higher than 130 and a secondary amine or a salt thereof. The poly-vinylpyrrolidone powder composition is produced by adding a secondary amine or a salt thereof to polyvinylpyrrolidone having a K value of not lower than 60 and not higher than 130, or by heat drying an aqueous solution containing polyvinylpyrrolidone having a K value of not lower than 60 and not higher than 130 and a secondary amine or a salt thereof.Type: GrantFiled: April 4, 2007Date of Patent: September 15, 2009Assignee: Nippon Shokubai Co., Ltd.Inventors: Takashi Miyai, Mitsuru Nakajima
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Patent number: 7541409Abstract: Hydrophobically modified polymers containing vinylamine or ethylenimine units and obtainable by reacting (a) polymers containing vinylamine or ethylenimine units with (b) compounds of the formula R-A-(EO, PO, BuO)n—X??(I), where R is C4- to C26-alkyl or C4- to C26-alkenyl, A is O, NH or COO, EO is an ethylene oxide unit, PO is a propylene oxide unit, BuO is a butylene oxide unit, n is from 1 to 250 and X is a functional group which can be covalently bonded to an OH group, process for the preparation of hydrophobically modified polymers containing vinylamine or ethylenimine units by reacting polymers containing vinylamine or ethylenimine units with a water repellent of the formula I and use of the polymers thus obtainable as an additive to paperstock in papermaking.Type: GrantFiled: May 19, 2003Date of Patent: June 2, 2009Assignee: BASF AktiengesellschaftInventors: Guenther Grimm, Volker Braig, Simon Champ, Norbert Mahr
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Patent number: 7473738Abstract: Lactam polymers has been modified with sodium borohydride (NaBH4) to yield lactam polymers bearing hydroxyl functional groups. These functional groups are useful for the covalent attachment of reactive groups, fluorescent probes, antimicrobial agents, bioactive factors, and drugs. The resulting as components for medical devices, specifically ophthalmic devices and more specifically contact lenses. Hydrogels based on these polymers are also useful for biomedical applications in the areas of drug delivery, tissue engineering, and implantable devices.Type: GrantFiled: September 30, 2004Date of Patent: January 6, 2009Assignee: Johnson & Johnson Vision Care, Inc.Inventors: Stephen C. Arnold, Walter R. Laredo
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Patent number: 7432331Abstract: The present invention is directed to hydrolytically stabilized maleimide-functionalized water soluble polymers and to methods for making and utilizing such polymers and their precursors.Type: GrantFiled: March 25, 2005Date of Patent: October 7, 2008Assignee: Nektar Therapeutics AL, CorporationInventors: Antoni Kozlowski, Remy F. Gross, III, Samuel P. McManus
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Patent number: 7432330Abstract: The present invention is directed to hydrolytically stabilized maleimide-functionalized water soluble polymers and to methods for making and utilizing such polymers and their precursors.Type: GrantFiled: December 31, 2003Date of Patent: October 7, 2008Assignee: Nektar Therapeutics AL, CorporationInventors: Antoni Kozlowski, Remy F. Gross, III, Samuel P. McManus
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Publication number: 20080241391Abstract: A method of manufacturing a metal nanoparticle includes coupling a metal ion to an organic ligand having a weight-average molecular weight of about 10,000 to about 1,500,000. The method further includes reducing the metal ion coupled to the organic ligand to form a metal nanoparticle having a skin layer.Type: ApplicationFiled: January 28, 2008Publication date: October 2, 2008Inventors: JANG SUB KIM, Soon-Kwon Lim, Joo-Ho Moon, Sun-Ho Jeong, Dong-Jo Kim, Kyoo-Hee Woo
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Patent number: 7399792Abstract: An object of the present invention is to provide a novel solid reagent capable of solving the problems of conventional solid reagents based on resin beads. The present invention relates to a solid reagent comprising an organic polymer base in which a polymer side chain is introduced onto the backbone of the organic polymer base via graft polymerization and a reactive functional group is introduced onto the polymer side chain. The organic polymer base is preferably in the form of a fiber, a woven or nonwoven fabric consisting of an assembly of fibers, a porous membrane or a hollow fiber membrane. The graft polymerization is preferably a radiation-induced graft polymerization. Solid reagents according to the present invention can be used in various organic synthetic reactions.Type: GrantFiled: March 3, 2006Date of Patent: July 15, 2008Assignee: Ebara CorporationInventors: Makoto Komatsu, Kazuyoshi Takeda
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Publication number: 20080153979Abstract: Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a wide range of possible functionalities, but typical have at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Also disclosed herein are non-natural amino acid polypeptides that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such polypeptides. Typically, the modified non-natural amino acid polypeptides include at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Further disclosed are methods for using such non-natural amino acid polypeptides and modified non-natural amino acid polypeptides, including therapeutic, diagnostic, and other biotechnology uses.Type: ApplicationFiled: October 16, 2007Publication date: June 26, 2008Applicant: AMBRX, INC.Inventors: Zhenwei MIAO, Junjie LIU, Thea NORMAN, Russell DRIVER
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Patent number: 7390853Abstract: An object of the present invention is to provide a novel solid reagent capable of solving the problems of conventional solid reagents based on resin beads. The present invention relates to a solid reagent comprising an organic polymer base in which a polymer side chain is introduced onto the backbone of the organic polymer base via graft polymerization and a reactive functional group is introduced onto the polymer side chain. The organic polymer base is preferably in the form of a fiber, a woven or nonwoven fabric consisting of an assembly of fibers, a porous membrane or a hollow fiber membrane. The graft polymerization is preferably a radiation-induced graft polymerization. Solid reagents according to the present invention can be used in various organic synthetic reactions.Type: GrantFiled: July 11, 2003Date of Patent: June 24, 2008Assignee: Ebara CorporationInventors: Makoto Komatsu, Kazuyoshi Takeda
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Patent number: RE44145Abstract: A method for preparing hydrophilic pressure sensitive adhesive (PSA) compositions is provided, wherein the method enables preparation of adhesives having a particular, optimized degree of adhesion. That is, the hydrophilic PSA is comprised of a hydrophilic polymer and a complementary short-chain plasticizing agent, wherein the hydrophilic polymer and plasticizing agent are capable of hydrogen bonding or electrostatic bonding to each other and are present in a ratio that optimizes key characteristics of the adhesive composition, such as adhesive strength, cohesive strength and hydrophilicity. The adhesive is useful in a wide variety of contexts, e.g., as a biomedical adhesive for application to the skin or other body surface, and as such finds utility in the areas of drug delivery systems (e.g., topical, transdermal, transmucosal, iontophoretic), medical skin coverings and wound healing products and biomedical electrodes.Type: GrantFiled: June 10, 2005Date of Patent: April 9, 2013Assignees: A.V. Topchiev Institute of Petrochemical Synthesis, Corium International, Inc.Inventors: Mikhail M. Feldstein, Anatoly E. Chalykh, Gary W. Cleary, Olga N. Emanuel
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Patent number: RE45666Abstract: A method for preparing hydrophilic pressure sensitive adhesive (PSA) compositions is provided, wherein the method enables preparation of adhesives having a particular, optimized degree of adhesion. That is, the hydrophilic PSA is comprised of a hydrophilic polymer and a complementary short-chain plasticizing agent, wherein the hydrophilic polymer and plasticizing agent are capable of hydrogen bonding or electrostatic bonding to each other and are present in a ratio that optimizes key characteristics of the adhesive composition, such as adhesive strength, cohesive strength and hydrophilicity. The adhesive is useful in a wide variety of contexts, e.g., as a biomedical adhesive for application to the skin or other body surface, and as such finds utility in the areas of drug delivery systems (e.g., topical, transdermal, transmucosal, iontophoretic), medical skin coverings and wound healing products and biomedical electrodes.Type: GrantFiled: February 6, 2013Date of Patent: September 8, 2015Assignees: A.V. Topchiev Institute of Petrochemical Synthesis, Corium International, Inc.Inventors: Mikhail M. Feldstein, Nicolai A. Platè, Anatoly E. Chalykh, Gary W. Cleary