Abstract: This invention provides emulsions and adhesives comprising proteins that can be isolated from a variety of sources including renewable plant biomass, and methods of making and using such emulsions and adhesives.

Abstract: Disclosed is a bio-based and environmentally friendly elastomer product from renewable agricultural substrates. Specifically, glutamine and arginine residues of gliadin are used as synthons to produce novel elastomeric product from the reaction of the oxirane groups of epoxidized vegetable oils under neat reaction conditions with the primary amide functionalities of glutamine and arginine to give the corresponding amidohyroxy gliadinyl triglycerides.

Abstract: A modified polyurethane including a lipid substituent pendant from at least one urethane nitrogen and/or at least one carbon atom of the modified polyurethane, methods of preparing modified polyurethanes and the use thereof as an implantable biomaterial.

Abstract: The present invention relates to compound of formula I, which are functionalized, non-phenolic amino acids, and polymers formed from the same. Polymers formed from the functionalized amino acids are expected to have controllable degradation profiles, enabling them to release an active component over a desired time range. The polymers are also expected to be useful in a variety of medical applications.

Abstract: A modified polyurethane including a lipid substituent from at least one urethane nitrogen and/or at least carbon atom of the modified polyurethane.

Abstract: The present invention relates to a solvent-free polyurethane-based artificial leather having the texture of human skin, and particularly to artificial leather comprising soy protein isolate and solvent-free polyurethane resin, where the use of soy protein isolate provides a higher water content than that of the conventional artificial leather to improve sensitivity properties such as tactile sensation and the use of the solvent-free polyurethane resin provides higher heat resistance and better mechanical properties than those of the conventional artificial leather, without using an organic solvent, thereby enabling to maintain clean indoor air.

Abstract: A method is provided for preparing a polyol from a protein-based precursor material, the polyol substitute thus produced, and a process for the use of the protein-based polyol substitute thus prepared for the further preparation of polyurethane.

Abstract: A copolymer comprising (a) one or more pendant group segments and (b) one or more polyol segments, each of said segments being linked to one or more further segments which may be the same or different, wherein said one or more pendant group segments are the same or different and are selected from: (i) siloxane segments; (ii) segments containing phosphoryl choline or a derivative or analogue thereof; (iii) segments containing a di- or trifluoromethyl group; (iv) heparin-like segments containing a group of formula (XII) D-N?N—Ar—SO3? ??(XII) wherein D is an aliphatic or aromatic group and Ar—SO3? comprises one or more linked aryl and/or heteroaryl groups, at least one of the aryl and/or heteroaryl groups having an SO3? substituent; and (v) segments containing a group of formula (I) [P]n?-[Lys]n-Lys-[Spacer]-Lys-[Al]x ??(I) wherein: [Al] is an inert amino acid; x is 0, 1, 2 or 3; [Spacer] is a fatty acid, amino acid, peptide or PEG; [P]n?-[Lys]n is a dendritic structure formed from n lysine group

Abstract: A modified polyurethane including a lipid substituent pendant from at least one urethane nitrogen and/or at least one carbon atom of the modified polyurethane, methods of preparing modified polyurethanes and the use thereof as an implantable biomaterial.

Abstract: Water-resistant, protein-based adhesive dispersion compositions and methods for preparing them are provided. The adhesive dispersions are prepared by copolymerizing a denatured vegetable protein, such as soy flour, that has been functionalized with methylol groups with one or more reactive comonomers, and preparing an acidic dispersion of the adhesive. The adhesive dispersions exhibit superior water resistance, and can be used to bond wood substrates, such as panels or laminate, or in the preparation of composite materials.

Abstract: The present invention relates to compound of formula I, which are functionalized, non-phenolic amino acids, and polymers formed from the same. Polymers formed from the functionalized amino acids are expected to have controllable degradation profiles, enabling them to release an active component over a desired time range. The polymers are also expected to be useful in a variety of medical applications.

Abstract: A method for encapsulating biologics within a hydrogel by using an aqueous solution of an isocyanate-functional hydrogel prepolymer which is mixed with an amount of biologics and an aqueous solution containing a dithiol crosslinking agent under physiological pH conditions. An additional bidentate crosslinking agent may be included. The product of such method may be a bioreactor or an assay device having a plurality or different biologics encapsulated at predetermined locations in a substrate.

Abstract: Cationic polyurethanes and polyureas formed from (a) at least one diisocyanate or reaction product thereof with one or more compounds containing two or more active hydrogen atoms per molecule, and (b) at least one diol, primary or secondary amino alcohol, primary or secondary diamine or primary or secondary triamine each with one or more tertiary, quaternary or protonated tertiary amine nitrogen atoms and having a glass transition temperature of at least 25° C. and an amine number of from 50 to 200, based on the non-quaternized or -protonated compounds, or other salts of these polyurethanes and polyureas, are useful as ingredients of cosmetic and pharmaceutical preparations.

Abstract: The present invention relates to a novel biopolymer consisting of a three-dimensional cross-linked mixture of (a) a cross-linking agent, activated with an activating agent, dissolved in a aqueous solution, and (b) a recombinant protein, namely polyubiquitin. The novel biopolymer is based on the cross-linking of ubiquitin (monomeric and/or polymeric) with a cross-linking agent, preferably bifunctionalized polyethylene oxides or a polyethylene glycol of various molecular masses (MW 2000 to 35 000 kDa), dissolved in aqueous solution in adequate proportions. The novel biopolymer offers a wide range of formulations since the number of ubiquitin units and cross-linking agent can vary both in length and ratio. The novel hydrogel is also biodegradable by a specific protease and is resistant to a wide range of other proteases.

Abstract: Methods for producing biocompatible heterogeneous proteinaceous networks crosslinked with a heterogeneous crosslinking agent, and the novel crosslinked networks.

Abstract: A biologic can be immobilized in a transparent polyurethane-hydrogel composition. Such a polyurethane-hydrogel composition can be prepared from forming a polyurethane-hydrogel mixture and immobilizing a biologic in the mixture. The mixture can be formed by admixing a prepolymer and a water-soluble crosslinker in aqueous solvent and in the substantial absence of organic solvent. A suitable prepolymer generally includes at least one water-soluble polyol and at least one isocyanate and can be added to the mixture in an amount of no greater than about 5 weight percent based on total weight of all components. A suitable crosslinker generally has a crosslinker functionality of at least 2. A biologic includes cells, peptides, nucleics, peptide nucleic acids, saccharides, lipopolysaccharides, glycolipids, and combinations of these. A polyurethane-hydrogel composition having an immobilized biologic can be particularly useful for biomedical applications.

Abstract: Biological tissue adhesives can be in the form of a gel that is applied to biological tissue as a “glue” or supported on a backing or substrate to form an article such as a self-sticking patch or pad. Adhesive articles can include such biological tissue adhesives or be functionalized to directly adhere to biological tissue without the biological adhesive.

Abstract: The present invention provides: a process for producing a water-absorbing agent by using a crosslinking agent of high safety, wherein the water-absorbing agent is excellent in the absorption capacities under no load and under a load and further in the blocking ratio under a load, and can display excellent absorption properties even if the weight percentage of the water-absorbent resin (resin concentration) is high when the water-absorbent resin is used for materials such as sanitary materials; and such a water-absorbing agent. The water-absorbent resin is mixed and treated with an oxazoline compound, wherein the oxazoline compound has at least three structural units of general formula (1) below: wherein R1˜R4 separately denote a hydrogen atom, an alkyl group, an aromatic group, a halogen group, a substituted alkyl group, or a substituted aromatic group.

Abstract: The present invention is a water-dispersible polyurethane composed of a polyurethane containing carboxylate groups covalently bonded to gelatin through a grafting agent. The polyurethane is formed by providing a polyurethane dispersion containing carboxylate groups wherein the polyurethane dispersion has an acid number of at least 5. The polyurethane dispersion is contacted with a grafting agent. The polyurethane dispersion with the grafting agent is contacted with gelatin to form a polyurethane covalently bonded to gelatin wherein a ratio of gelatin to polyurethane is from 1:10 to 2:1.

Abstract: A hemocompatible surface-modifying additive is provided for modifying polyurethane or polyurethane urea substrates. The additive has a polyurethane or polyurethane urea hard block or an alternative block which is miscible with the poly(urethane) or poly(urethane-urea) base polymer, a polysiloxane hydrophobic soft block, an optional hydrophilic spacer and a peptide selected from the group consisting of Arg-Gly-Asp, X-Arg-Gly-Asp, Arg-Gly-Asp-X and X-Arg-Gly-Asp-X', wherein X and X' are amino acids.

Abstract: A method for producing an ester of a protein by an esterification reaction of an aqueous solution, fine powder or suspension of a protein having free carboxyl groups with an excess amount of polyfunctional alcohol to esterify the protein; a method for producing a protein-synthetic polymer conjugate from said ester by utilizing a hydroxyl or unsaturated group of a polyfunctional alcohol present in the esterified portion of the protein; and a protein-synthetic polymer conjugate produced thereby.

Abstract: A medical device has one or more polymeric substrates each treated with a chemically binding coating to make each polymeric substrate compatible for contact with blood. A modified natural and substantially hydrophilic blood protein bonds permanently to each substrate. The protein is functionalized with bonding sites so after application thereof to each substrate and if subject to sufficient radiation, free radicals created on each substrate and the functionalized protein chemically bind. A modifier added to the protein creates sites by functionalizing it before application to each substrate. The functionalized combination is applied to each substrate. The protein is human or animal albumin as bovine.The modifier are molecules having an epoxy function for attachment to the human or animal albumin. An unsaturated double bond forms or accepts free radicals at bonding sites. The modifier added to the protein is glycidyl acrylate.

Abstract: Amino-sulfhydryl cross-linking reagents that are cleavable under mildly acidic conditions are disclosed. Also disclosed are methods of making the cross-linkers, as well as methods of using the cross-linkers, e.g., to deliver a biologically active substance across the membranes of selected cells in a heterogeneous cell population; once inside the cell the active substance is released, intact, by the transient, mild acidity of certain cell structures. Finally, a method of characterizing complex multi-chain protein structures is disclosed.

Abstract: Polyalkylenepolyamines are crosslinked in a non-anhydrous environment to yield water-swellable, essentially water-insoluble gels. The polyalkylenepolyamine is contacted with a polyisocyanate at a pH between about 5 and about 8 and subjected to a high rate of agitation. The process of this invention can be employed to immobilize proteins, enzymes, antibodies, etc.

Abstract: The instant invention is directed to a process for the production of denatured polyaddition products of biomasses and isocyanates, comprising reacting(A) from 5 to 98%, by weight, based on (A)+(B), of a biomass based on microorganisms or derivative and decomposition products thereof with(B) from 95 to 2%, by weight, based on (A)+(B), of a compound containing isocyanate groups, at temperatures of at least 50.degree. C. with complete denaturing of component (A).

Abstract: The present invention provides an albumin-fixed resin comprising a crosslinked water-insoluble resin and albumin chemically bound thereto, said water-insoluble resin being a crosslinked epoxy resin containing about 1 to about 30 milliequivalents of amino groups and about 1 to about 50 milliequivalents of hydroxyl groups per gram thereof, said albumin being ionically bound to the amino groups of the epoxy resin and to the hydroxyl groups by hydrogen bonding, and the amount of said albumin fixed being at least about 25% by weight based on the epoxy resin, and also provides a process for producing the albumin-fixed resin, which comprises(1) (a) subjecting a polyepoxy compound containing at least two epoxy groups in the molecule and a polyamine compound containing at least two primary and/or secondary amino groups in the molecule to addition reaction in an inert medium to produce a fully crosslinked resin, or (b) subjecting said compounds to addition reaction to produce an insufficiently crosslinked pre-polymer,