Abstract: The present invention relates to novel compositions of therapeutic cyclodextrin containing polymeric compounds designed as a carrier for small molecule therapeutics delivery and pharmaceutical compositions thereof. These cyclodextrin-containing polymers improve drug stability and solubility, and reduce toxicity of the small molecule therapeutic when used in vivo. Furthermore, by selecting from a variety of linker groups and targeting ligands the polymers present methods for controlled delivery of the therapeutic agents. The invention also relates to methods of treating subjects with the therapeutic compositions described herein. The invention further relates to methods for conducting pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the polymeric compounds described herein.

Abstract: The present invention relates to novel compositions of therapeutic cyclodextrin containing polymeric compounds designed as a carrier for small molecule therapeutics delivery and pharmaceutical compositions thereof. These cyclodextrin-containing polymers improve drug stability and solubility, and reduce toxicity of the small molecule therapeutic when used in vivo. Furthermore, by selecting from a variety of linker groups and targeting ligands the polymers present methods for controlled delivery of the therapeutic agents. The invention also relates to methods of treating subjects with the therapeutic compositions described herein. The invention further relates to methods for conducting pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the polymeric compounds described herein.

Abstract: The present invention relates to novel compositions of therapeutic cyclodextrin containing polymeric compounds designed as a carrier for small molecule therapeutics delivery and pharmaceutical compositions thereof. These cyclodextrin-containing polymers improve drug stability and solubility, and reduce toxicity of the small molecule therapeutic when used in vivo. Furthermore, by selecting from a variety of linker groups and targeting ligands the polymers present methods for controlled delivery of the therapeutic agents. The invention also relates to methods of treating subjects with the therapeutic compositions described herein. The invention further relates to methods for conducting pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the polymeric compounds described herein.

Abstract: The present invention relates to novel compositions of therapeutic cyclodextrin containing polymeric compounds designed as a carrier for small molecule therapeutics delivery and pharmaceutical compositions thereof. These cyclodextrin-containing polymers improve drug stability and solubility, and reduce toxicity of the small molecule therapeutic when used in vivo. Furthermore, by selecting from a variety of linker groups and targeting ligands the polymers present methods for controlled delivery of the therapeutic agents. The invention also relates to methods of treating subjects with the therapeutic compositions described herein. The invention further relates to methods for conducting pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the polymeric compounds described herein.

Abstract: The present invention relates to novel compositions of therapeutic cyclodextrin containing polymeric compounds designed as a carrier for small molecule therapeutics delivery and pharmaceutical compositions thereof. These cyclodextrin-containing polymers improve drug stability and solubility, and reduce toxicity of the small molecule therapeutic when used in vivo. Furthermore, by selecting from a variety of linker groups and targeting ligands the polymers present methods for controlled delivery of the therapeutic agents. The invention also relates to methods of treating subjects with the therapeutic compositions described herein. The invention further relates to methods for conducting pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the polymeric compounds described herein.

Abstract: A method for the production of a cross-linked support matrix that in form of a bed will permit liquid flow velocities above 5 cm/h, preferably above 50 cm/h, to pass through the bed. The method is characterized in that it comprises the steps: (a) providing a starting support matrix that has pendent unsaturated groups, and (b) subjecting said starting support matrix to electron beam or gamma-ray irradiation. The use of a cross-linked support matrix produced by a method comprising the steps of: (a) providing a starting support matrix that has pendent unsaturated groups, and (b) subjecting said starting support matrix to electron beam or gamma-ray irradiation as a support matrix in liquid chromatography, cell culturing, step-wise solid phase synthesis of organic compounds, running catalytic reactions by the use of a solid phase bound catalyst.

Abstract: An amphoteric polymer dispersion obtained in the presence of at least one of starch or a starch derivative by a two-stage polymerization using anionic and cationic monomers is useful as a sizing agent for paper products, as a coating for various substrates, and as a binder in pigment-free coatings or pigment-containing coatings. The dispersion is exceptionally compatible with widely differing sizing agent systems and coating chemicals.

Abstract: The present invention discloses a process for manufacturing a grafted polyacrylamide flocculant of cationic/ampholytic ions, which is characterized by graft-copolymerizing starch or micro-crystalline cellulose as backbone with acrylamide, while using potassium permanganate as initiator, hydrolyzing and thereafter reacting with alkyl-amino-carbinol. Optionally, the product may also contain additives. It has advantages in readily available raw materials, low cost of production, simple technology and mild reaction conditions. The product has good overall performance, high flocculating ability, wide applicability and is an ideal sludge-dewatering agent and sewage treating agent.

Abstract: A process for producing an amphoteric aqueous polymer dispersion by two-step radical copolymerization includes (a) decomposing a starch by treatment with an enzyme or acid hydrolysis to provide a starch solution composed of decomposed starch and/or derivatives thereof having an average molecular weight ranging from 500 to 2000 g/mole and with the starch solution having an internal viscosity<0.

Abstract: The present invention relates to a new form of biocompatible materials (e.g., lipids, polycations, polysaccharides) which are capable of undergoing free radical polymerization, e.g., by using certain sources of light; methods of modifying certain synthetic and naturally occurring biocompatible materials to make polymerizable microcapsules containing biological material coated with said polymerizable materials, composites of said polymerizable materials, methods of making microcapsules and encapsulating biological materials therein, and apparatus for making microcapsules containing biological cells (particularly islets of Langerhans) coated with polymerizable alginate or with a composite thereof (e.g., alginate and PEG). The present invention also relates to drug delivery systems relating to the foregoing, as well as bioadhesives and wound dressings made utilizing the foregoing technology.

Abstract: A method for producing sucrose-based epoxy monomers having one to eight epoxy groups per molecule of sucrose, which comprises reacting a mixture comprising: a sucrose monomer having an allyl-containing group on at least one of the hydroxyl groups, and a reagent or catalyst selected from molybdenum, tungsten, vanadium, titanium and peracid, in the presence of hydrogen peroxide or a derivative thereof, in relative amounts sufficient to produce a sucrose-based epoxy monomer. Monomers thus produced are also provided. The sucrose-based epoxy monomers can be cured to produce a sucrose-based epoxy resin. Such resins are useful, for example, as adhesives, composites and coatings.

Abstract: A process for preparing a modified polysaccharide graft copolymer complex which comprises the steps of:i. subjecting polysaccharide to graft copolymerization with a vinyl monomer;ii. treating the polysaccharide graft copolymer with:a. polyethylene glycol to provide a polymer-PEG complex; orb. a silicate compound to provide a silica precipitated polymer; andiii. recovering the polymer-PEG complex or silica precipitated polymer.This modified polysaccharide graft copolymer may be used as a surface sizing agent in the preparation of paper.

Abstract: Graft polymers are obtainable by free radical polymerization of(A) monomers or monomer mixtures of(a) from 10 to 100% by weight of open-chain N-vinylcarboxamides(b) from 0 to 90% by weight of other, carboxyl-free monoethylenically unsaturated monomers which are copolymerizable with the monomers (a) and(c) from 0 to 5% by weight of monomers containing two or more ethylenically unsaturated, non-conjugated double bonds in the molecule,in the presence of(B) natural substances containing saccharide structures, such as mono-, oligo- and polysaccharides,in a weight ratio (A):(B) of from 95:5 to 20:80 and, if required, subsequent hydrolysis of the amido groups of the polymerized monomers (a) of the graft polymer with formation of amino groups, and said polymers are used as dry and wet strength agents for paper, board and cardboard.

Abstract: Disclosed is a binder insolubilizer for use in binder-containing paper coating compositions, the insolubilizer consisting essentially of an aqueous formulation containing at least about 15 weight percent of titratable glyoxal and at least one polyhydroxy compound.

Abstract: Polysaccharide graft polymers which comprise an acetal-containing or aldehyde-containing homopolymer or copolymer grafted to a polysaccharide base have been prepared. The monomer repeating units in the homopolymer are derived from one or more ethylenically or allylically unsaturated monomers containing an acetal group or aldehyde group; The monomer repeating units in the copolymer are derived from the above monomer and derived from one or more ethylenically or allylically unsaturated monomers other than the acetal-containing or aldehyde-containing monomer. A and A' are independently a lower alkyl or A and A' together form at least a 5-membered cyclic acetal; with the proviso that the graft polymer contain no ##STR1## groups when the aldehyde groups are present. The aldehyde-containing graft polymers are useful for imparting wet strength to paper.

Abstract: A coating binder additive is prepared comprising a blocked glyoxal resin mixed with a vinyl or acrylic water soluble polymer which is reactive with free glyoxal.

Abstract: A method is provided for treating and modifying solid, high molecular weight Lewis base polymers, particularly shaped structures such as fibers, filaments or knitted fabrics, to form branched polymer with improved electrical conductivity, water absorbency and dye receptivity while retaining the essential structural shape. The method comprises heating the polymer in the presence of an aqueous treating solution containing an ethylenically unsaturated monomer which does not readily polymerize under the conditions of treatment and a catalyst which is a source of hydrogen ions or protons. The treatment is carried out at a temperature and for a sufficient time so as to effect essentially single molecule addition of the monomer pendent to the polymer chain with substantially no graft polymerization of the monomer to the polymer. A particularly preferred embodiment of the method is the treatment of nylon 6,6 knitted fabric with an aqueous solution of acrylamide and hydrochloric acid for about one hour at 95.degree.

Abstract: Water-absorbent resins having improved water-absorbency, water-absorption rate and water-dispersibility can be produced by crosslinking a water-absorbent resin comprising a carboxylate as a constituent of the resin with a crosslinking agent having at least two functional groups in the presence of water in a proportion of 0.01 to 1.3 parts by weight per part by weight of the resin in an inert solvent.

Abstract: Water-absorbent resins having improved water-absorbency, water-absorption rate and water-dispersibility can be produced by crosslinking a water-absorbent resin comprising a carboxylate as a constituent of the resin with a crosslinking agent having at least two functional groups in the presence of water in a proportion of 0.01 to 1.3 parts by weight per part by weight of the resin in an inert solvent.

Abstract: Two types of water soluble complexes of retinoids possessing vitamin A-like biological activity and use but of lower toxicity are disclosed: (A) Cyclodextrin complexes of retinoid-polymers and (B) Complexes of retinoids with ether type derivatives of cyclodextrins.