Abstract: Provided herein are assay control materials comprising stable analytes and lyophilized unstable analytes, and methods of making and using the same.

Abstract: A unit dose package of a liquid nutritional product comprises a form-stable, cup shaped container with a capacity of less than 70 ml having a rim, a frustoconical sidewall and a base. A quantity of the nutritional product is enclosed within the container and a foil closure is sealed to the rim. The container is formed of a laminate comprising a barrier layer of highly 5 orientable EVOH having an ethylene content of less than 31 mol %, preferably around 27 mol %, and an oxygen transmission of less than 0.0068 ml/ml/year, between an inner carrier layer and an outer carrier layer. The package is especially adapted for long term storage of oxygen sensitive products.

Abstract: A method of filling CARC (chemical agent resistant coating) applicators ensures integrity of the CARC paint.

Abstract: The present invention relates to packaging material and its use in the shelf-life extension and quality improvement of products.

Abstract: The present application provides a unique process of canning a controlled substance where the cans are hermetically sealed and clearly identified in a number of different ways. The process will begin by inserting a packing and dehumidifying agent, preferably a formed rice cake. The controlled substance is then inserted. In some cases the rice cakes will be eliminated or just a single rice cake will be used on the top or the bottom. If the process of storing the controlled substance in an inert atmosphere is desired, the oxygen in the container is replaced with gaseous nitrogen. After the container has been sealed in the conventional pop-top canning procedure; an identifying scent substance is permanently adhered to the can or label. An internal or external microchip could be used to detect, track and trace the container filled with a controlled substance.

Abstract: A container containing a fluorinated organic carbonate and a gas atmosphere which contains a cover gas selected from the group consisting of a noble gas, e.g., argon, xenon, a gaseous fluorinated aliphatic carbon which is heavier than air and does not interfere with the fluorinated organic compound, SF6, and any mixture thereof. Fluorinated organic carbonates are highly suitable as solvents or additives for solvent in Li ion batteries and consequently, must be kept in a very pure state even during expanded times of storage. The argon or xenon gas atmosphere prevents the intrusion of air or moisture even if the container is opened and the liquid handled in an environment of common air. A method of storing one or more fluorinated organic carbonates in a safe manner.

Abstract: A method is provided for preparing spray dried powder containing vancomycin hydrochloride. The method comprises providing a vancomycin hydrochloride solution with a chromatographic purity of at least 95%, adding an excipient to the vancomycin hydrochloride solution to form a mixture solution of the vancomycin hydrochloride solution and the excipient, concentrating the mixed solution of the vancomycin hydrochloride solution and the excipient to form a 20% to 30% vancomycin concentrate, filtering the vancomycin concentrate to form a final filtrate, and spray drying the final filtrate to form a spray dried vancomycin hydrochloride powder with EP impurity B level of not more than 1.5%.

Abstract: A device for treating at least one container, preferably for filling at least one container with a fill product and/or for reshaping a container, comprising an isolator chamber containing a defined atmosphere, in which the treatment of the container is carried out, and at least one container channel for conveying the container into the isolator chamber or for conveying the container out of the isolator chamber, and a suction device for sucking air out of the container channel and out of the isolator chamber, and a supply air preparation unit for preparing the air to be fed to the isolator chamber, wherein the suction device is connected with the supply air preparation unit in such a manner that at least a portion of the air sucked out of the container channel and/or the isolator chamber is fed to the supply air preparation unit for renewed preparation.

Abstract: A container for culturing a test sample includes a molded monolithic single layer polymeric container body having an upwardly extending, visually transmissive wall with an inner surface and a wall thickness that is between about 0.2 mm and 10 mm. The container also has a thin gas barrier coating comprising silica on the inner surface of the sealed container body and an internal top coating on the gas barrier coating. The gas barrier and top coating are visually transmissive (after curing). The container includes a cap sealably attached to the container body. The sealed container has an oxygen transmission rate (OTR) after autoclaving and aging that is between about 0.0001 to about 0.04 (cc/package/day/atm).

Abstract: High purity cyclohexasilane and a method for increasing the purification efficiency thereto are provided. The method for producing cyclohexasilane of the present invention is characterized in that, in distilling crude cyclohexasilane to obtain purified cyclohexasilane, the absolute pressure during distillation is set to 2 kPa or less, and the heating temperature of crude cyclohexasilane is set to 25 to 100° C. The cyclohexasilane of the present invention contains pure cyclohexasilane at a rate of 98% by mass or more and 100% by mass or less.

Abstract: A vapor hydrated packaged catheter assembly and method of manufacturing and distributing same includes a gas impermeable package housing a catheter within a catheter-receiving cavity. The catheter assembly has a hydrophilic coating applied to at least a portion of the outer surface of a catheter tube or shaft which may be surrounded by a sleeve to provide a no-touch, sure grip feature. The catheter assembly is disposed within the catheter receiving cavity of the package together with a limited amount of a vapor donating liquid provided as a source of vapor to activate the hydrophilic coating. The amount of vapor donating liquid is less than the amount that would otherwise be sufficient to cause a spill hazard. It may be loose liquid as a desired percentage of the volume of a tube-receiving portion of the catheter receiving cavity of the package, or it may be contained in a liquid sequestering element.

Abstract: An packaging apparatus is disclosed that comprises, a tray having a top surface, a bottom surface, and a sidewall, one or more compartments integrally formed with and extending from the tray, and one or more pods for housing a product, the pods further comprising, a pouch with a cover secured to the pouch to provide closure of the pod, the cover including a bottom cover surface and a top cover surface, and a tab layer secured at least partially to the top cover surface, wherein the pods are received and at least partially enclosed by the compartments, and the pods are secured to the tray.

Abstract: A method for introducing at least one substance into a sealed enclosure holding at least one product. At least one conduit may be provided through which one of gas or fluid may flow into or out of the sealed enclosure. Air may be evacuated from the sealed enclosure through the at least one conduit to create a predetermined pressure within the sealed enclosure and a predetermined quantity of the at least one substance may be injected into the sealed enclosure through the at least one conduit.

Abstract: System, method and material for making pneumatically filled packing cushions in which a plastic film material having two superposed layers joined together along first and second longitudinal edges is prefabricated at a first location by forming longitudinally spaced, transversely extending rows of perforations across it and sealing it together along seal lines which extend from the first edge of the material in a direction generally parallel to the rows of perforations other and terminate a short distance from the second edge to form chambers with open mouths facing the second edge between the rows of perforations. The material is then fan-folded or formed into rolls for storage and shipment. At a second location, gas is introduced into the chambers by passing the material along a tube positioned between the ends of the seals and the second edge of the material and injecting the gas into the open mouths of the chambers through openings in a side wall of the tube.

Abstract: A medical container includes: a container body, a mouth section through which liquid can enter and exit, a proximal-end opening, and a proximal-end edge portion surrounding the proximal-end opening; a plug body that seals the mouth section; a bag body having a bag-like shape and including an edge portion that is tightly fixed to the proximal-end edge portion and seals the proximal-end opening, and a reversing part which is surrounded by the edge portion, has flexibility, and is reversed inside/outside; and a space surrounded by the container body, the plug body and the bag body. The reversing part is reversed inside/outside when the liquid enters and exits the space through the mouth section, whereby the reversing part can take a first state in which the reversing part expands toward a distal end side, and a second state in which the reversing part expands toward the proximal end side.

Abstract: The present invention relates to a method for packing polysilicon in the form of chunks by introducing the chunks into a first plastic bag, the first plastic bag being introduced into a second plastic bag after the introduction of the chunks, or the first plastic bag already having been inserted into the second plastic bag prior to the introduction of the chunks into the first plastic bag, as a result of which the chunks are present in a double bag which is sealed, wherein the air present in the two plastic bags in the double bag after the introduction of the chunks is removed before the sealing of the double bag such that the total volume of the double bag relative to the volume of the chunks is 2.4 to 3.0.

Abstract: A dianhydrohexitol packaged in a packaging material that is impervious to gas, wherein the partial pressure of oxygen inside the packaging is 0.1 to 10 mbar, preferably 0.5 to 5 mbar, and more preferably 0.5 to 2 mbar. The method for packaging dianhydrohexitol, includes inserting the dianhydrohexitol into a packaging material that is impervious to gas, and then hermetically sealing the packaging, the method being carried out in an atmosphere that has a partial pressure of oxygen of 0.1 to 10 mbar, preferably 0.5 to 5 mbar, and more preferably 0.5 to 2 mbar.

Abstract: A packaging method for packaging fluid (P) in a fluid dispenser comprising a fluid reservoir (1) defining an opening (13), and a fluid dispenser member (2), such as a pump or a valve, for mounting in leaktight manner on the opening (13) of the reservoir, an inert gas, such as nitrogen or argon, being present in the reservoir above the fluid (P) while the dispenser member (2) is being mounted in leaktight manner on the opening (13) of the reservoir, such that the fluid (P) is in contact with the inert gas in the reservoir (1); the method being characterized in that the step of mounting the dispenser member (2) in leaktight manner on the opening (13) of the reservoir (1) is performed under a vacuum, the inert gas is evacuated, at least in part, from the reservoir during this evacuation step, such that the reservoir is subjected to an inert-gas vacuum.

Abstract: The invention relates to a method for attaching lipstick to a lipstick dispenser and to a corresponding machine. The method for attaching lipstick to a dispenser, wherein the dispenser includes a distal end for the lips, and the dispenser includes a receptacle having an insertion opening fitted to a proximal end of the stick. The method includes: a moving step in which the insertion opening and the proximal end of the stick are moved adjacent to one another so as to substantially block the insertion opening; and a nesting step in which the stick is nested in the receptacle via a recess formed in the receptacle.

Abstract: An apparatus for closing containers includes a movable closing head for applying closures to the containers and is arranged in the interior of a sterile chamber of the apparatus and arranged to move in a longitudinal direction (L) of the containers to be closed. At least one wall is provided which delimits the sterile chamber, wherein the closing device is arranged on a carrier which is arranged partially inside the sterile chamber and partially outside the sterile chamber, and extends through the wall and moves in the longitudinal direction (L) relative to the wall. Arranged in the interior of the sterile chamber is a first sealing element which is elastic in the longitudinal direction (L) and which seals off from the sterile chamber a region of the outer periphery of the carrier.

Abstract: A packaging apparatus (1) comprises: a housing (11); an actuator (12) configured to move the housing between a first position, in which a package (22) is unconstrained by the housing, and a second position, in which the housing houses the package (22); and a gas blower (13) configured to introduce a flow of gas into the housing via a gas inlet (15), wherein the gas blower comprises a fan.

Abstract: A package for an article (1) comprises a pressurized outer bag (5) having gas-tight seals (7) at opposite ends, and an inner web for supporting the article within the outer bag. The web extends along the length of the outer bag and is secured to the outer bag only at the gas-tight seals (7). The web is maintained under sufficient tension by the pressure within the outer bag to suspend the article within the bag and to maintain a space between the article and the outer bag on all sides of the article.

Abstract: A load port device conveys a container including a gas port to an outer conveyor unit by using a ceiling transportation vehicle. The load port device includes a conveyor, a purging device, and a stocker controller. The conveyor extends to the outer conveyor unit. The purging device is arranged near the outer conveyor unit, and includes a gas supply nozzle to supply purge gas into the container while connected to the gas port, and a first lifting mechanism that moves the gas supply nozzle toward or away from a gas supply port. The stocker controller controls the purging device to supply the purge gas into the container, and to stop supplying the purge gas into the container based on an arrival of the ceiling transportation vehicle to the outer conveyor unit.

Abstract: A water- and oxygen-occlusive pack is described. The pack encloses an inert atmosphere containing medicinal tablets, wherein the tablets contain buprenorphine or a salt or ester thereof.

Abstract: An automatic packaging apparatus is provided, having a conveyor, a continuous longitudinally folded web, and cutting and sealing mechanisms for forming flexible pouches from the web. Each flexible pouch has an open end and an overlap portion specifically suitable for operation with the apparatus of this invention. The open end is separated and a load is inserted into one of the flexible pouches. After the load is inserted, air is withdrawn and a gas is preferably injected into the flexible pouch by a plurality of flat-profile snorkels, or a single, wider snorkel. The flexible pouch is then heat sealed to form a gas-tight seal. Controls, preferably including a servo mechanism, are used to simultaneously operate the cutting, sealing, fluid transfer and product infeed stations of the automatic packaging apparatus. As the flexible pouch moves from the fluid transfer station to the sealing station, the gas-tight seal is maintained.

Abstract: A method for introducing at least one substance into a sealed enclosure holding at least one product. The sealed enclosure having at least one conduit through which one of gas or fluid may flow into or out of the sealed enclosure. Air is evacuated from the sealed enclosure through the at least one conduit to create a predetermined pressure within the sealed enclosure and a predetermined quantity of the at least one substance is injected into the sealed enclosure through the at least one conduit.

Abstract: A device for the pressurization and evacuation of a gas in a bottle, in order to approximate the unopened (ambient) conditions of a previous gaseous state in said bottle. Two units comprise this system, namely a charging unit and a sealing-valve unit. When the charging unit is coupled to the sealing-valve unit three functions can be performed. The first is a priming function where the bottle is partially evacuated of its ambient air and replaced with a gas from a cartridge. The second is a charging function where the primed bottle is pressurized with the same gas type or mixture from the pressurized gas cartridge. The third is an evacuating function where the charged bottle can be bled of gas to achieve the approximate ambient condition of an unopened bottle. This function is used when a bottle is overcharged and a lower pressure is desired.

Abstract: A system for storing items is provided. The system includes a rigid chamber having an internal space and including a mechanism for generating a storage space within said internal space, said storage space having reduced volume and optionally pressure as compared to said internal space. According to still further features in the described preferred embodiments the system further comprises a device for creating a pressure difference between a first and a second surface of the pliable sheet to thereby generate the storage space characterized by reduced volume and pressure as compared to the internal space.

Abstract: A kit and methods for determining the gender of an unborn fetus. The kit comprises a container holding a solid composition therein, the solid composition including a basic salt and a transition metal separated by a filler and in which an atmosphere in the container is substantially free of water.

Abstract: A valve (20) is provided for sealing an evacuation port (16) in a port area (18) of a wall structure (12) of a container. The valve (20) comprises a casing (22) having a shell portion (30) which is deformable from an open condition, whereat the shell portion (30) forms a chamber (32) over the port area (18), and a closed condition, whereat the shell portion (30) contacts the port area (18). When the shell portion (30) is in its open condition, gas exits from the chamber (32) through gas-releasing holes (24) in the casing (22). When the shell portion (30) is deformed to its closed condition, a port-sealing adhesive (26) adheres to the port area (18) to thereby seal the evacuation port (16).

Abstract: A vacuum storage container having a container body, a check valve and a lid with an outer rim surrounding a diaphragm. A vacuum pump is engagable with the check valve to remove air from the interior of the container to create a vacuum in the container. The diaphragm is pushed inward by atmospheric forces upon removal of the air until the diaphragm touches and conforms to at least upper exposed surfaces of the contents of the container. The storage container aids in preventing degradation of the contents of the container by maintaining the contents free from the degrading effects of air and by substantially immobilizing the contents during movement of the container to protect the contents from breakage and bruising.

Abstract: A method of at least one embodiment of the present invention for packing a TAB tape is a method in which the TAB tape is wound on a core reel so as to be packed, the TAB tape being a tape-shaped insulating film on which circuits are provided in a repeated manner, the circuits each of which is made up of metal wiring and a solder resist. In at least one embodiment, the method includes a first step of winding at least the TAB tape on an outer peripheral surface of a core reel having a cylindrical shape, the core reel having a shaft hole on its inner peripheral side. This makes it possible to provide (i) a method for packing a TAB tape which method makes it possible to reduce a packing size, and (ii) a smaller packing structure for a TAB tape.

Abstract: A method of smoke-infusing proteinaceous foods comprises the following sequential steps: a) enclosing the proteinaceous foods in a vacuum-treating zone; b) introducing smoke directly or indirectly from a smoke generation zone into the vacuum-treating zone; c) subjecting the proteinaceous foods to vacuum purging at a negative pressure in the vacuum-treating zone, thereby infusing smoke into the proteinaceous foods; d) repeating the steps of introducing smoke directly or indirectly from the smoke generation zone into the vacuum-treating zone; subjecting the proteinaceous foods to vacuum purging at a negative pressure in the vacuum-treating zone at least fifty times in pulsed sequences of smoke introduction stage/vacuum purging stage/vacuum release stage for the efficient infusion of smoke into the proteinaceous foods; and e) a post-chill resting cycle of the smoke-infused proteinaceous foods at a suitable temperature and for a suitable period of time.

Abstract: The invention relates to aerated soap bars. Generally, it is difficult to get aerated soap bars with the right level of aeration, because high viscosity of the molten soap mass sometimes makes it difficult to aerate it to the desired extent. The size and movement of air bubbles also play important roles. Bars with larger air bubbles have lower mechanical strength. We have determined that use of acrylates or cellulose ethers in aerated soap bars lead to bars with acceptable rate of wear, mush and lower density. The soaps also have a higher and more uniform air incorporation and better air retention. Disclosed are aerated soap bars having density from 0.2 to 0.99 g/cm3, comprising: (i) 20 to 80 wt % soap; (ii) 2 to 40 wt % polyol; (iii) 5 to 50% water; and, (iv) 0.5 to 5 wt % electrolyte; wherein the bars comprise 0.1 to 5 wt % polymer selected from acrylates or cellulose ethers.

Abstract: A process for making a multi-compartment water-soluble pouch having at least three compartments and wherein at least one of the compartments contains a composition in liquid form, the process comprising the steps of: a) providing a mold with at least two recesses; b) drawing a first film into the mold to form at least two open compartments in the at least two recesses; c) filling the open compartments; d) pin-pricking the first film to create a pin-hole; e) drawing a second film over the open compartments to close those compartments and to form a new open compartment, wherein the second film directly covers the pin-hole; f) filling the open compartment formed from the second film; and g) placing a closure film over the new filled open compartment to close it.

Abstract: A rigid holding container has a flexible cover sheet extending over the holding area for sealing the contents. The container has a wide, flat perimeter lip which provides a firm base for the seal between the cover sheet and the container. A breaching bubble is formed in the seal, under the cover and over the perimeter lip. The consumer breaches the bubble by pressing the bubble against the lip between the thumb and forefinger. The pressure compresses the air in the bubble causing the bubble to expand laterally. The expanding bubble breaches along the perimeter of the lip, producing a peel flap of flexible cover material. The consumer pulls the peel flap while holding the rigid container down, to remove the cover sheet.

Abstract: A method and packaging system for forming a sealed vacuum package having minimal residual air remaining. At least one vacuum lance is provided in the interior of a partially-formed package to withdraw the air, the package being closed on three sides and having a fourth side open for insertion of the vacuum lance. An air restriction can be provided along the fourth side to form a closed edge that prevents ingress of air into the package interior after the evacuation of air. In one aspect, the air restriction may comprise a pair of pinch rollers that compress the package at the fourth side edge to form a pinch seal that provides a relatively airtight air chamber inside of the package prior to and during sealing of the package. In another aspect, the air restriction may comprise a partial seal formed around the lances to prevent or minimize air from reentering the package.

Abstract: A method for reducing a cushion footprint for long-term storage may include inserting a foam core into a plastic cover, subsequently applying a vacuum to the plastic cover, and, while under the vacuum effect, sealing the plastic cover, and its contents. A device providing the vacuum effect may include a surface having protruding sections connected to non-protruding sections via tapered sections. A cushion may include an at least 20 density high resiliency foam core, and a fabric cover that includes (a) a combination of polyester and spandex and/or lycra, (b) nylon to which a thin water resistant material coating is applied, and/or (c) polyester fabric including raised anti-slip polyvinyl chloride dots, other portions of the polyester fabric at which the dots are not positioned having applied thereto a polyvinyl chloride coating. The device may compress the foam core while housed in a fabric cover, housed in the plastic cover.

Abstract: A method for packaging a fluid product dispenser, where the said dispenser includes a reservoir (1) of constant effective volume filled with a fluid product (10), and a dispensing device (3) that includes a dip tube (2) which is intended to extract the fluid product (10) contained in the reservoir on operation of the dispensing device (3), the reservoir (1) and the dip tube (2) being made from a material or materials that are substantially or perfectly transparent, where the said dip tube initially contains air (A), and the dip tube (2) is connected to the dispensing device and has one free end extending to the bottom of the reservoir, the method being characterized in that the air (A) is extracted from the dip tube (2) and is replaced by the fluid product.

Abstract: Method and assembly for evacuating a package (2), such as a vacuum package filled with a product such as nuts. The package is at least partially made of packaging film (6). The method employs a suction device (4) provided with a suction opening, for evacuating the package through an aperture (12) in the packaging film. The package is provided with a substantially plate-shaped, rigid element (8), one main surface of which substantially lying in contact “with the inner side of the packaging film, wherein the aperture in the packaging film is provided at the location of the substantially rigid element. The method further includes the sealing abutment of the suction opening against an outer side of the package, at a location where the substantially rigid element lies in contact with the inner side of the packaging film, in such a way that the aperture is in fluid connection with the suction opening.

Abstract: An inflatable dunnage for use in transporting biocontainers, a method for packaging a biocontainer with such dunnage and a package including such dunnage and a biocontainer. The inflatable dunnage includes an inflatable body defining opening for receiving at least one of a tubing and a fitting of a biocontainer, a port for the inlet of air, and a valve coupled to the port for controlling the inlet and outlet of air.

Abstract: The subject invention provides a pharmaceutical composition comprising N-ethyl-N-phenyl-1,2,-dihydro-4-hydroxy-5- chloro-1-methyl-2-oxoquinoline-3-carboxamide or the salt thereof; a pharmaceutically acceptable carrier; and not more than 0.5% w/w relative to N-ethyl-N-phenyl-1,2,-dihydro-4 -hydroxy-5-chloro-1-methyl-2-oxoquinoline-3-carboxamide of 2-Chloro-6-(1-ethyl-N-methyl-2-oxoindoline-3-carboxamido) benzoic acid, 1H,3H-spiro[5-chloro-1-methylquinoline-2,4 -dione-3,3?-[1]ethylindolin-[2]-one], or 5-Chloro-N-ethyl-3-hydroxy-1-methyl-2,4-dioxo-N-phenyl-1,2,3,4 -tetrahydro-quinoline-3-carboxamide.

Abstract: A process for pressurizing a container assembly includes engaging the outer container around a neck of the outer container at a location between a shoulder of the outer container and a mouth of the outer container with a neck clamp device. The neck clamp device is used to support the outer container as the outer container moves from one location to a different location. An at least partial seal is formed about the neck of the outer container by engaging the neck clamp device with an outer bell member of a crimper-pressurized fluid fill head.

Abstract: The invention relates to a thermoform packaging machine for manufacturing a multilayer package, to methods for manufacturing a multilayer package comprising three or four product layers as well as to multilayer packages comprising three or four product layers.

Abstract: A vacuum seal valve is applied to a lid for the air-tight closing of a container for the packaging of products, particularly food products, including a closing body arranged for sealing a hole for evacuating air from the container, from which at least one punching member stems that is adapted to pierce the lid closing the container so as to form such evacuating hole. A reciprocating mechanical vacuum pump, with manual actuation, evacuates air from a container arranged for the vacuum packaging of products, for example food products, via application of the vacuum sealing valve. The pump has, at its base, a recess adapted to form a housing for retaining the valve, whereby the lowering movement of the plunger allows driving the valve in a lid of the container.

Abstract: A food container (2) includes a rigid thermoformed plastics carton (4) which holds a dry food 6 and is closed by a removable film closure (8). The film (8) incorporates a hydride which is arranged to generate hydrogen on contact with moisture. Additionally, the film (8) is arranged to have relatively high water vapour permeability and relatively low hydrogen gas permeability. In use, water vapour from air surrounding the container (2) passes into the film (8) and reacts with the hydride to generate hydrogen. Due to the relatively low hydrogen permeability of the film (8), the hydrogen is restricted from escaping from the container. Instead, the hydrogen then reacts with any oxygen within the container in a reaction catalysed by a catalyst associated with the carton (4), thereby to scavenge oxygen within the container (2) and protect the food (6) from oxidation.

Abstract: An system and method for coupling a capsule body and cap is provided. The system and method provide a first conduit configured to align a capsule body and a second conduit configured to align a capsule cap. The system and method provide for a pressure-relief cavity in at least one of the first conduit and the second conduit.

Abstract: An anti-drying device (10) is to humidify a delivery unit (21) for fluid and semi-fluid products, pastes, gels, creams such as for example coloring products, pigments or paints, of a machine (75) for the automatic delivery of a fluid product in a closed container (11). A closed container or receptacle (79) inside which there is a fluid, liquid and/or vapor. The container (79) is configured to house, inside it, the delivery unit (21) to prevent the delivery unit from drying out.

Abstract: The present invention relates to a method, a device, and a control program for the fluid-tight sealing of capsules containing medicaments, wherein the capsules consist of at least one capsule body and a capsule cap which are set one into the other telescopically and provided with a tight band in the abutment region on the exterior side of the capsule, wherein the capsule components are filled with gas which has a changed temperature and/or a changed pressure in relation to the environment, and wherein a reduction of the difference in pressure in the capsule occurs via gaps between capsule body and capsule cap after the capsule components have been placed one inside the other. The capsules produced via the method according to the invention are disposable capsules and preferably contain a single dose of an orally administered pharmaceutical formulation in the form of a powder or a liquid.

Abstract: The subject invention is directed to a pharmaceutical composition comprising an open matrix network carrying a pharmaceutically active ingredient, wherein the open matrix network comprises levan.