Polymer Supported Synthesis, E.g., Solid Phase Synthesis, Merrifield Synthesis, Etc. Patents (Class 530/334)
-
Patent number: 7381408Abstract: The invention provides methods of chemically synthesizing chimeric proteins comprising at least a portion of an immunoglobulin constant region and a biologically active molecule.Type: GrantFiled: May 6, 2004Date of Patent: June 3, 2008Assignee: Syntonix Pharmaceuticals, Inc.Inventors: Adam R. Mezo, Robert T. Peters
-
Publication number: 20080119637Abstract: The invention provides extraction columns for the purification of an analyte (e.g., a biological macromolecule, such as a polypeptide or protein) from a sample solution, as well as methods for making and using such columns. The columns typically include a bed of extraction medium in a column. In some embodiments, the extraction columns employ modified pipette tips as column bodies. In some embodiments, the invention provides resins and methods that facilitate elution of analyte in a small volume of liquid. In some embodiments, the analyte is an active protein.Type: ApplicationFiled: November 20, 2007Publication date: May 22, 2008Inventors: Douglas T. Gjerde, Liem Nguyen, Jeremy Lambert
-
Patent number: 7375085Abstract: In the present specification is disclosed a melanocyte-stimulating hormone inhibitory composition which comprises, as the active ingredient, a di- or tripeptide derivative having a certain naphthyl group or the salts thereof, or a melanocyte-stimulating hormone inhibitory compound having a 50% inhibitory concentration of cAMP production (IC50) of 100 nM or less, which composition can prevent pigmentation, or can prevent, improve or recover from immune abnormality or immunodeficiency, or regulate body weight by appetite control, and also can be used as cosmetics or external preparations for the skin, and in addition, can be produced easily, and are excellent in the stability during storage.Type: GrantFiled: April 25, 2000Date of Patent: May 20, 2008Assignee: Ajinomoto Co., Inc.Inventors: Eiji Shiojiri, Yoshinobu Takino, Hiromi Chujou, Kazutami Sakamoto, Chiori Ijichi, Yuzuru Eto, Keiji Iwasaki
-
Publication number: 20080108790Abstract: A novel method for on-resin formation of disulfide-borne cyclization of peptides is devised.Type: ApplicationFiled: October 26, 2005Publication date: May 8, 2008Applicant: LONZA AGInventors: Stephane Varray, Oleg Werbitzky, Thomas Zeiter
-
Patent number: 7348404Abstract: The present invention relates to an improved process for the production of peptides by solid-phase synthesis. The invention also relates to agents which are useful in solid-phase peptide synthesis.Type: GrantFiled: June 19, 2006Date of Patent: March 25, 2008Assignee: Zealand Pharma A/SInventors: Arne Holm, Bjarne Due Larsen
-
Patent number: 7314708Abstract: A self-addressable, self-assembling microelectronic device is designed and fabricated to actively carry out and control multi-step and multiplex molecular biological reactions in microscopic formats. These reactions include nucleic acid hybridization, antibody/antigen reaction, diagnostics, and biopolymer synthesis. The device can be fabricated using both microlithographic and micro-machining techniques. The device can electronically control the transport and attachment of specific binding entities to specific micro-locations. The specific binding entities include molecular biological molecules such as nucleic acids and polypeptides. The device can subsequently control the transport and reaction of analytes or reactants at the addressed specific micro-locations. The device is able to concentrate analytes and reactants, remove non-specifically bound molecules, provide stringency control for DNA hybridization reactions, and improve the detection of analytes. The device can be electronically replicated.Type: GrantFiled: August 4, 1998Date of Patent: January 1, 2008Assignee: Nanogen, Inc.Inventors: Michael J. Heller, Eugene Tu
-
Patent number: 7312195Abstract: This invention relates to cyclised conotoxin peptides, processes for their preparation and their pharmaceutical use.Type: GrantFiled: February 7, 2005Date of Patent: December 25, 2007Assignee: The University of QueenslandInventors: David James Craik, Norelle Lee Daly, Katherine Justine Nielsen, Christopher John Armishaw, Richard Clark, Paul Francis Alewood
-
Patent number: 7273846Abstract: The present invention features truncated hMCH analogs selectively active at MCH-1R over MCH-2R. Using amino acid numbering provided in hMCH, the featured analogs contain an X6 which is either a D-amino acid, 5-guanidinopropionic acid or its lower or higher homolog, or a derivative thereof; and a X10 which is either asparagine, glutamine, alanine, leucine, isoleucine, valine, norleucine, cyclohexylalanine, phenylalanine, (2?)-naphthylalanine, tyrosine, histidine, tryptophan, lysine, serine, threonine, methionine, or a derivative thereof.Type: GrantFiled: January 6, 2003Date of Patent: September 25, 2007Assignee: Merck & Co., Inc.Inventor: Maria A. Bednarek
-
Patent number: 7268210Abstract: PEG-LHRH analog conjugates, where a PEG moiety is covalently bound to a serine residue of a LHRH analog, and methods for producing these conjugates are provided in the present invention. Also provided are a pharmaceutical composition and a method for treating pathologies in which LHRH analog administration is beneficial.Type: GrantFiled: May 24, 2005Date of Patent: September 11, 2007Assignee: Applied Research Systems ARS Holding N.V.Inventors: Nabil El-Tayar, Xuan Zhao, Michael D. Bentley
-
Patent number: 7259142Abstract: A compound of formula: in which (i) aa1 is Adi and aa4 is Glu or (ii) each of aa1 and aa4 is Adi, L is sulfur, sulfoxide, oxygen or methylene, which compound (and its conjugates) bind to an SH2 domain in a protein comprising an SH2 domain, is non-phosphorylated, is redox-stable in vivo, is characterized by an IC50 in vivo of less than about 4.0 ?M with respect to the SH2 domain in Grb2, and, upon binding to the SH2 domain of Grb2, has a turn conformation. A conjugate comprising a compound as described above and a carrier agent, a composition comprising (i) a compound or a conjugate as described above and (ii) a carrier, a method of inhibiting binding of an SH2 domain in a protein comprising an SH2 domain to a target protein in an animal, wherein the SH2 domain is contacted with a target protein-binding inhibiting effective amount of a compound or a conjugate as described above, and a method of synthesizing such conjugates.Type: GrantFiled: September 13, 2005Date of Patent: August 21, 2007Assignee: The United States of America, represented by the Secretary, Department of Health and Human ServicesInventors: Peter P Roller, Ya-Qui Long, Feng-Di T. Lung, C. Richter King, Dajun Yang, Johannes H. Voigt
-
Patent number: 7247701Abstract: Synthetic methods and compounds involving amino amides, peptides and peptidomimetics. Amino amide derivatives are prepared via the one-step three-component reaction of a glyoxamide, an amine, and an organoboron derivative. Conversion of the product to another glyoxamide intermediate allows the iterative use of this chemistry for the synthesis of peptides and peptidomimetics.Type: GrantFiled: September 14, 2005Date of Patent: July 24, 2007Assignee: University of Southern CaliforniaInventors: Nicos A. Petasis, Xin Yao
-
Patent number: 7244815Abstract: The present invention provides a process for preparing a peptide of formula I): Sub-[L]-[N(R1)-A-C(O)]p—[NH-A-C(O)]n+m—OH??(I) comprising: (a) reacting an immobilized compound of formula (II): Sub-(L)-[N(R1)-A-C(O)]p—[NH-A-C(O)]n—OH??(II) with an amino acid ester or peptide derivative of formula (III): H—[NH-A-C(O)]m—O(tBu)??(III) in the presence of a coupling agent to yield a peptide compound of general formula (IV): Sub-[L]-[N(R1)-A-C(O)]p—[NH-A-C(O)]n+m—O(tBu);??(IV) (b) removing the tBu (t-butyl) group to produce a solid-support bound carboxylic acid or peptide derivative of general formula (I); wherein n is a positive integer, e.g., 1–10, preferably 1–5; m is a positive integer, and P is 0–1.Type: GrantFiled: May 19, 2004Date of Patent: July 17, 2007Assignee: The Curators of the University of MissouriInventor: William G. Gutheil
-
Patent number: 7220720Abstract: The present invention features truncated MCH analogs active at the MCH receptor. The truncated MCH analogs are optionally modified peptide derivatives of mammalian MCH. The analogs can bind to the MCH receptor and, preferably, bring about signal transduction. MCH analogs have a variety of different uses including being used as a research tool and being used therapeutically.Type: GrantFiled: February 1, 2001Date of Patent: May 22, 2007Assignee: Merk & Co., Inc.Inventor: Maria A. Bednarek
-
Patent number: 7214769Abstract: The present invention provides a process for preparing a peptide of formula (I): Sub-[L]-[NH-A-C(O)]n+m—OH??(I) comprising: (a) reacting an immobilized compound of formula (II): Sub-(L)-[NH-A-C(O)]n—OH??(II) ?with an amino acid ester or peptide derivative of formula (III): H—[NH-A-C(O)]m—O(tBu)??(III) ?in the presence of a coupling agent to yield a peptide compound of general formula (IV): Sub-[L]-[NH-A-C(O)]n+m—O(tBu);??(IV) (b) removing the tBu (t-butyl) group to produce a solid-support bound carboxylic acid or peptide derivative of general formula (I); wherein n is a positive integer, e.g., 1-10, preferably 1-5; m is a positive integer.Type: GrantFiled: May 23, 2002Date of Patent: May 8, 2007Assignee: The Curators of the University of MissouriInventors: William G. Gutheil, Qingchai Xu
-
Patent number: 7192713Abstract: The present invention provides novel stabilized crosslinked compounds having secondary structure motifs, libraries of these novel compounds, and methods for the synthesis of these compounds libraries thereof. The synthesis of these novel stabilized compounds involves (1) synthesizing a peptide from a selected number of natural or non-natural amino acids, wherein said peptide comprises at least two moieties capable of undergoing reaction to promote carbon-carbon bond formation; and (2) contacting said peptide with a reagent to generate at least one crosslinker and to effect stabilization of a secondary structure motif. The present invention, in a preferred embodiment, provides stabilized p53 donor helical peptides. Additionally, the present invention provides methods for disrupting the p53/MDM2 binding interaction comprising (1) providing a crosslinked stabilized ?-helical structure; and (2) contacting said crosslinked stabilized ?-helical structure with MDM2.Type: GrantFiled: May 18, 2000Date of Patent: March 20, 2007Assignee: President and Fellows of Harvard CollegeInventors: Gregory L. Verdine, Christian E. Schafmeister
-
Patent number: 7176282Abstract: The present invention relates to an improved process for the production of peptides by solid-phase synthesis. The invention also relates to agents, which are useful in solid-phase peptide synthesis.Type: GrantFiled: April 18, 2000Date of Patent: February 13, 2007Assignee: Zealand Pharma A/SInventors: Arne Holm, Bjarne Due Larsen
-
Patent number: 7166696Abstract: Functionalized supports and methods for solid phase synthesis. Preferably, the functionalized support is azlactone-functionalized.Type: GrantFiled: July 27, 2004Date of Patent: January 23, 2007Assignee: 3M Innovative Properties CompanyInventors: Jerald K. Rasmussen, Larry R. Krepski
-
Patent number: 7160862Abstract: Peptide sequences comprising 10 to 50 amino acids are disclosed. The sequences are characterized by containing at least one of an integrin binding motif such as an RGD sequence, a glycosaminoglycan binding motif, and a calcium binding motif, and the remainder of amino acids contiguous with the RGD sequence in matrix extracellular phosphoglycoprotein. The sequences may be formulated for injection or dispersed in toothpaste or a mouthwash or gum patch and administered to enhance bone/tooth growth and/or reduce excessive urinary phosphate loss from the body.Type: GrantFiled: January 24, 2005Date of Patent: January 9, 2007Assignee: Acologix, Inc.Inventors: Yoshinari Kumagai, Toshiyuki Yoneda, Russell Wayne Blacher, Motoyoshi Nomizu
-
Patent number: 7153933Abstract: A solid phase synthesis method for preparing peptide-spacer-lipid conjugates, the peptide-spacer-lipid conjugates synthesized by the method, and liposomes containing the peptide-spacer-lipid conjugates. The present invention provides a convenient solid phase synthesis method for preparing peptide-spacer-lipid conjugates and provides various linkage groups (such as amide group) for conjugating peptide, spacer and lipid, wherein the spacer may comprise PEG. Several advantages can be achieved, such as the synthetic procedure can be simplified, the synthesis process can be set to automation, the purification is easier in each reaction step, and the product losses can be reduced to minimal during synthesis.Type: GrantFiled: December 3, 2002Date of Patent: December 26, 2006Assignee: Development Center for BiotechnologyInventors: Shih-Kwang Wu, Ting-Gung Chang, Chin-Lu Tseng, Li-Jung Chen, Kae-Shyang Shih
-
Patent number: 7138489Abstract: The present invention is a method for producing a peptide or a protein in which a side chain contains a modified amino acid residue, which comprises chemically producing a peptide fragment containing an amino acid residue having a modified side chain using an weak acid-cleavable resin, producing a peptide fragment containing no amino acid residue having a modified side chain using a genetic recombination method or/and an enzymatic method, and condensing the resulting two kinds of peptide fragments and, according to the present invention, a peptide or a protein containing modification such as acylation, glycosylation and phosphorylation can be obtained effectively and at high quality.Type: GrantFiled: April 10, 2003Date of Patent: November 21, 2006Assignee: Daiichi Asubio Pharma Co., Ltd.Inventors: Yoshiharu Minamitake, Masaru Matsumoto, Tomohiro Makino
-
Patent number: 7122628Abstract: A process for the solid phase synthesis of a peptide having at least one thyptophan residue, wherein said method comprises temporarily protecting the indole ring of said tryptophan residue with a side chain protecting group which is labile to a base wherein said protecting group is removed during cleavage of said peptide from the solid support.Type: GrantFiled: December 19, 2001Date of Patent: October 17, 2006Assignee: Ipsen Manufacturing Ireland, LimitedInventor: Steven Allen Jackson
-
Patent number: 7119064Abstract: The present invention provides methods that utilize compositions containing colostrinin, a constituent peptide thereof, an active analog thereof, and combinations thereof, as modulators of intracellular signaling molecules, for example.Type: GrantFiled: October 22, 2003Date of Patent: October 10, 2006Assignee: Board of Regents, The University of Texas SystemInventors: Istvan Boldogh, G. John Stanton, Jerzy A. Georgiades, Thomas K. Hughes, Jr., Marian Kruzel
-
Patent number: 7109162Abstract: The present invention relates to a purified antioxidant polypeptide, a method of isolating and purifying said polypeptide, and method of enhancing antioxidant properties of a composition comprising addition of said polypeptide to the composition. The antioxidant is formulated alone as a nutritional supplement or is combined with other consumable products, such as foods, beverages, vitamins, herbal extracts, or other antioxidants. The present invention also relates to methods for identifying and quantifying the antioxidant polypeptide in food and beverages.Type: GrantFiled: July 31, 2001Date of Patent: September 19, 2006Assignee: World Resourses CorporationInventors: N. Lee Wolfe, Neeraj Datta
-
Patent number: 7094609Abstract: A method for preparing very large spatially-addressable arrays of chemical compounds by light-directed synthesis is provided, wherein the light is provided by a laser and the compounds are arrayed on a rotating disc in a CD-ROM format. A method for assaying the resulting array with a CD-ROM mechanism is also provided.Type: GrantFiled: September 19, 1997Date of Patent: August 22, 2006Assignees: Burstein Technologies, Inc., Nagaoka & Co. Ltd.Inventor: James Paul Demers
-
Patent number: 7094871Abstract: The present invention provides methods, apparatus and kits for synthesizing assembled peptides and proteins on a solid phase with sequential ligation of three or more unprotected peptide segments using chemoselective and mild ligation chemistries in aqueous solution. Also provided are methods of monitoring solid phase sequential ligation reactions using MALDI or electrospray ionization mass spectrometry of reaction products.Type: GrantFiled: November 15, 2001Date of Patent: August 22, 2006Assignee: Gryphon TherapeuticsInventors: Lynne Canne, Stephen B. H. Kent, Reyna Simon
-
Patent number: 7091314Abstract: More efficient and/or economical methods for synthesizing heptapeptide alcohol analogs of oxytocin are provided along with novel intermediates which are useful in synthesizing such oxytocin analogs. Efficient and economical methods for synthesizing intermediates useful in synthesizing these oxytocin analogs are also provided.Type: GrantFiled: July 8, 2004Date of Patent: August 15, 2006Assignee: Ferring BVInventors: Kazimierz Wisniewski, Jacek Stalewski, Guangcheng Jiang
-
Patent number: 7083914Abstract: A method and apparatus for the physico-chemical encoding of a collection of beaded resin (“beads”) to determine the chemical identity of bead-anchored compounds by in-situ interrogation of individual beads. The present invention provides method and apparatus to implement color-coding strategies in applications and including the ultrahigh-throughput screening of bead-based combinatorial compounds libraries as well as multiplexed diagnostic and environmental testing and other biochemical assays.Type: GrantFiled: November 22, 1999Date of Patent: August 1, 2006Assignee: BioArray Solutions Ltd.Inventors: Michael Seul, Richard H. Ebright
-
Patent number: 7070936Abstract: The present invention provides a method for identifying inhibitors of protein kinases. Methods are also provided for inhibiting protein kinase activity. Specific non-peptide protein tyrosine kinase inhibitor are provided. The protein kinases produced using the method of the present invention may be used to treat a number of conditions in patients, including cancer, psoriasis, arthrosclerosis, or immune system activity.Type: GrantFiled: January 13, 2000Date of Patent: July 4, 2006Assignee: The Research Foundation of State University of New YorkInventors: David G. Hangauer, Jr., Thomas H. Marsilje, Karen L. Milkiewicz
-
Patent number: 7067623Abstract: A solid phase synthetic method is disclosed in which the usual solid phase synthetic steps are carried out and the spent solid phase support is reacted to form a volatilizable compound upon cleavage of the reaction product from the solid phase support. The cleaved product is then separated from the volatile compound by volatilization of that compound. Exemplary solid supports that form a volatilizable compound are also disclosed.Type: GrantFiled: November 1, 2002Date of Patent: June 27, 2006Assignee: Mixture Sciences, Inc.Inventors: Jeanick H. Pascal, Michael J. Moran, Richard A. Houghten
-
Patent number: 7067326Abstract: Libraries of synthetic receptors are disclosed. The receptors include a polyfunctional organic template which is covalently linked to two or more oligomers. The oligomers may be the same or different and may be straight chain, cyclic or branched. The template may be linked to an identifier which is unique to each synthetic receptor. Although the identifier may be directly attached to the template, it is more common and preferable that the template be covalently linked to a solid support which is itself linked to the identifier. Methods of preparing synthetic receptors and libraries of synthetic receptors are also disclosed as are methods for assaying the libraries to determine which receptors have various desirable characteristics. Among the desirable characteristics are (a) the ability to bind an acceptor molecule; (b) biological activity; (c) the ability to catalyze or inhibit a reaction and (d) potential utility for separating compounds in chromatography.Type: GrantFiled: January 13, 1995Date of Patent: June 27, 2006Assignee: The Trustees of Columbia University in the City of New YorkInventors: W. Clark Still, Ge Li, Helma Wennemers
-
Patent number: 7060673Abstract: The present invention relates to a fusion peptide wherein a self cell-penetrating Tat peptide having a self penetrating signal is bound to a human parathyroid hormone-derived peptide, a preparation thereof, and a skin slimming cosmetic composition comprising the same. Since the fusion peptide wherein the Tat peptide is bound to the human parathyroid hormone-derived peptide has high stability and superior skin absorption, the present invention provides a skin slimming agent having superior lipolysis effects and improved durability of the effects.Type: GrantFiled: May 6, 2002Date of Patent: June 13, 2006Assignee: LG Household and Health Care Ltd.Inventors: Young-Sook Song, Nae-Gyu Kang, Sun-Gyoo Park, Wan-Goo Cho, Yong-Hwa Lee, Jun-Man Lim, Hye-Jung Min, Min-Youl Chang, Seh-Hoon Kang
-
Patent number: 7049293Abstract: A peptide has any one of the sequences SEQ ID NO.1 to SEQ ID NO.8, or has a sequence derived from any one of the sequences SEQ ID NO.1 to SEQ ID NO.8 by substitution, deletion or addition of one or several amino acids therein and having an osteogenetic activity.Type: GrantFiled: July 15, 2003Date of Patent: May 23, 2006Assignee: Kyocera CorporationInventors: Yoshihiko Nishimura, Yoshihisa Suzuki, Masao Tanihara
-
Patent number: 7045503Abstract: Novel metal binding ligands are disclosed that may be coupled to peptides for use in methods of diagnosis and therapy. Peptides containing the ligands are produced using a method wherein ligand introduction or cyclization can be conducted at any point during the synthesis of the peptide. Such peptide derivatives are readily labeled with radiometals, such as isotopes of rhenium or technetium, while retaining their ability to tightly bind specific peptide receptors.Type: GrantFiled: October 2, 2000Date of Patent: May 16, 2006Assignee: Immunomedics, Inc.Inventors: William J. McBride, Gary L. Griffiths
-
Patent number: 7030217Abstract: The present invention provides methods, apparatus and kits for synthesizing assembled peptides and proteins on a solid phase with sequential ligation of three or more unprotected peptide segments using chemoselective and mild ligation chemistries in aqueous solution. Also provided are methods of monitoring solid phase sequential ligation reactions using MALDI or electrospray ionization mass spectrometry of reaction products.Type: GrantFiled: November 15, 2001Date of Patent: April 18, 2006Assignee: Gryphon Therapeutics, Inc.Inventors: Lynne Canne, Stephen B. H. Kent, Reyna Simon
-
Patent number: 7030216Abstract: Molecules having potential biological activity, particularly peptoids, that are conjugated to solid phase supports, spacer groups, and/or ligation moieties, and methods of their preparation, are described. In some instances, the molecules of the invention are made entirely by solid phase synthesis. In other instances, the spacer groups are hydrophilic and compositions containing them, and to solid phase synthesis of varied structure peptoids using chemoselective ligation moieties.Type: GrantFiled: April 5, 2002Date of Patent: April 18, 2006Assignee: Chiron CorporationInventors: Thomas Horn, Ronald N. Zuckermann
-
Patent number: 7026114Abstract: VLSIPS™ manufacturing processes are of increasing commercial importance. The present invention provides methods and compositions for monitoring the efficiency and quality of polymer synthesis in VLSIPS™ arrays. Methods for monitoring polymer synthesis in an array on a substrate are provided. Monoisomeric labels for the labeling of synthetic polymer arrays are provided. Methods and compositions for post-synthetically labeling polymers in polymer arrays are also provided.Type: GrantFiled: November 30, 1995Date of Patent: April 11, 2006Assignee: Affymetrix, Inc.Inventors: Anthony D. Barone, Glenn H. Mc Gall, Evelyn Chai, Nam Quoc Ngo
-
Patent number: 7015192Abstract: The peptide has a sequence of 3 to 30 adjacent amino acids from the amino end of protein SNAP-25 and is useful as neuronal exocytosis inhibitor. The cosmetic and pharmaceutical compositions contain said peptide and optionally one or more peptides from the carboxyl end of SNAP-25. Said compositions are suitable for the treatment of facial wrinkles and asymmetry and pathological neuronal exocytosis-mediated pathological disorders and alterations.Type: GrantFiled: February 18, 2000Date of Patent: March 21, 2006Assignee: Lipotec, S.A.Inventors: Ma Clara Blaines Mira, Ma Mercedes Llobregat Hernandez, Ana Isabel Gil Tebar, Gregorio Joaquin Fernandez Ballester, Rosa Ma Planell Cases, Antonio Vicente Ferrer Montiel, Salvador Viniegra Bover, Luis Miguel Gutierrez Perez, Teresa Carbonell Castello, Enrique Perez Paya
-
Patent number: 7001883Abstract: This invention relates to cyclized conotoxin peptides, processes for their preparation and their pharmaceutical use.Type: GrantFiled: September 14, 1999Date of Patent: February 21, 2006Assignee: The University of QueenslandInventors: David James Craik, Norelle Lee Daly, Katherine Justine Nielsen
-
Patent number: 6995136Abstract: A peptide factor, its analogs and methods of using such peptide factor derived from murine epidermal growth factor peptide is disclosed wherein the peptide factor is modified to protect it from proteolytic degradation and the peptide binds to laminin receptors.Type: GrantFiled: April 21, 1999Date of Patent: February 7, 2006Assignee: The Queen's University of BelfastInventors: John Nelson, Brian Walker, Neil McFerran, Patrick Harriott
-
Patent number: 6982315Abstract: The invention relates to a process for the preparation of carboxamides, in particular peptides, from an acid component in the form of a compound containing at least one carboxyl group and an amine component in the form of a compound containing at least one primary or secondary amino group, and its use.Type: GrantFiled: March 27, 2002Date of Patent: January 3, 2006Assignee: Bayer AktiengesellschaftInventors: Joachim Rudolph, Günther Jung, Bernd Thern
-
Patent number: 6977292Abstract: The invention is directed to nucleophile-stable thioester generating compounds comprising a carboxyester thiol. The compounds have wide applicability in organic synthesis, including the generation of peptide-, polypeptide- and other polymer-thioesters. The invention is particularly useful for generating activated-thioesters from precursors that are made under conditions in which strong nucleophiles are employed, such as peptides or polypeptides made using Fmoc SPPS, as well as multi-step ligation or conjugation schemes that require (or benefit from the use of) compatible selective approaches for directing a specific ligation or conjugation reaction of interest.Type: GrantFiled: August 30, 2001Date of Patent: December 20, 2005Assignee: Gryphon TherapeuticsInventors: Paolo Botti, James A. Bradburne, Stephen B. H. Kent
-
Patent number: 6962902Abstract: This invention relates generally to dipeptides and tripeptides and to methods for pharmaceutical treatment of mammals using analogs of such dipeptides and tripeptides. More specifically, the invention relates to tripeptides and their analogs, to pharmaceutical compositions containing such dipeptides and tripeptides and to methods of treatment of mammals using such dipeptides and tripeptides. In addition, the invention relates to methods of treatment of mammals using such dipeptides and tripeptides for control of appetite, blood pressure, cardiovascular response, libido, and circadian rhythm.Type: GrantFiled: May 18, 2004Date of Patent: November 8, 2005Assignee: University of CincinnatiInventors: Ambikaipakan Balasubramanium, William T. Chance
-
Patent number: 6946542Abstract: Synthetic methods and compounds involving amino amides, peptides and peptidomimetics. Amino amide derivatives are prepared via the one-step three-component reaction of a glyoxamide, an amine, and an organoboron derivative. Conversion of the product to another glyoxamide intermediate allows the iterative use of this chemistry for the synthesis of peptides and peptidomimetics.Type: GrantFiled: April 1, 2003Date of Patent: September 20, 2005Assignee: University of Southern CaliforniaInventors: Nicos A. Petasis, Xin Yao
-
Patent number: 6939847Abstract: The present invention provides methods that utilize compositions containing colostrinin, an constituent peptide thereof, an active analog thereof, and combinations thereof, as an oxidative stress regulator.Type: GrantFiled: October 28, 2002Date of Patent: September 6, 2005Assignee: Board of Regents, The University of Texas SystemInventors: G. John Stanton, Thomas K. Hughes, Jr., Istvan Boldogh
-
Patent number: 6929907Abstract: This application describes an antibody that specifically binds to a synthetic oligomer (e.g., an oligonucleotide or oligopeptide) having a organic protecting group covalently bound thereto, which antibody does not bind to that synthetic oligomer when the organic protecting group is not covalently bound thereto. Methods of making and using such antibodies are also disclosed, along with cells for making such antibodies and articles carrying immobilized oligomers that can be used in assay procedures with such antibodies.Type: GrantFiled: December 22, 2000Date of Patent: August 16, 2005Assignee: North Carolina State UniversityInventor: Paul F. Agris
-
Patent number: 6921636Abstract: The invention provides apparatus and methods for determining the nucleotide sequence of target nucleic acids using hybridization to arrays of oligonucleotides. The invention further provides apparatus and methods for identifying the amino acid sequence of peptides that bind to biologically active macromolecules, by specifically binding biologically active macromolecules to arrays of peptides or peptide mimetics.Type: GrantFiled: November 16, 2000Date of Patent: July 26, 2005Assignee: Metrigen, Inc.Inventor: Thomas M. Brennan
-
Patent number: 6921748Abstract: The present invention provides peptides which stimulate the release of insulin. The peptides, based on GIP 1-42, include substitutions and/or modifications which enhance and influence secretion and/or have enhanced resistance to degradation. The invention also provides a process of N terminally modifying GIP and the use of the peptide analogues for treatment of diabetes.Type: GrantFiled: March 29, 2000Date of Patent: July 26, 2005Assignee: Uutech LimitedInventors: Finbarr Paul Mary O'Harte, Peter Raymond Flatt
-
Patent number: RE39545Abstract: The present invention provides labeled synthetic libraries of random oligomers and methods and apparatus for generating labeled synthetic oligomer libraries. Each member of such a library is labeled with a unique identifier tag that specifies the structure or sequence of the oligomer. In a preferred embodiment of the present invention the identifier tag is a microchip that is pre-encoded or encodable with information that is related back to a detector when the identifier tag is pulsed with electromagnetic radiation.Type: GrantFiled: May 7, 2004Date of Patent: April 3, 2007Assignee: Nexus Biosystems, Inc.Inventor: John Cargill
-
Patent number: RE39571Abstract: The present invention provides labeled synthetic libraries of random oligomers and methods and apparatus for generating labeled synthetic oligomer libraries. Each member of such a library is labeled with a unique identifier tag that specifies the structure or sequence of the oligomer. In a preferred embodiment of the present invention the identifier tag is a microchip that is pre-encoded or encodable with information that is related back to a detector when the identifier tag is pulsed with electromagnetic radiation.Type: GrantFiled: May 7, 2004Date of Patent: April 17, 2007Assignee: Nexus Biosystems, Inc.Inventor: John Cargill
-
Patent number: RE39606Abstract: The present invention provides labeled synthetic libraries of random oligomers and methods and apparatus for generating labeled synthetic oligomer libraries. Each member of such a library is labeled with a unique identifier tag that specifies the structure or sequence of the oligomer. In a preferred embodiment of the present invention the identifier tag is a microchip that is pre-encoded or encodable with information that is related back to a detector when the identifier tag is pulsed with electromagnetic radiation.Type: GrantFiled: May 7, 2004Date of Patent: May 1, 2007Assignee: Nexus Biosystems, Inc.Inventor: John Cargill