Gelatin Patents (Class 530/354)
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Publication number: 20120135448Abstract: The present invention provides methods and devices for the fabrication of 3D polymeric fibers having micron, sub-micron, and nanometer dimensions, as well as methods of use of these polymeric fibers.Type: ApplicationFiled: May 13, 2010Publication date: May 31, 2012Applicant: President and Fellows of Harvard CollegeInventors: Kevin Kit Parker, Mohammad Reza Badrossamay, Josue Adrian Goss
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Publication number: 20120130047Abstract: The invention discloses a process for the acceleration of gelling time of regenerated silk fibroin using gelling agent, preferably silica to create a porous structure, devoid of microbial growth.Type: ApplicationFiled: July 30, 2010Publication date: May 24, 2012Applicant: COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCHInventors: Shailesh Prakash Nagarkar, Ashish Kishore Lele
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Publication number: 20120122133Abstract: The subject invention provides novel devices and methods for the detection of the presence and/or activity of proteases in biological samplesType: ApplicationFiled: November 15, 2011Publication date: May 17, 2012Inventors: Gregory S. Schultz, John I. Azeke, Daniel J. Gibson, Olajompo B. Moloye, Priscilla Lorraine Phillips, Weihong Tan, Christopher D. Batich
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Publication number: 20120107372Abstract: The invention concerns a recombinant CBE gelatin and recombinant gelatins having multimers of the CBEmonomersequence that are of particular use in several applications involving cell attachment such as in cell culture work and applications involving cell cultures of anchor dependent cells and also in a variety of medical applications.Type: ApplicationFiled: December 2, 2011Publication date: May 3, 2012Inventors: Arjo Lysander De Boer, Hendrik Van Urk, Jan Bastiaan Bouwstra, Peter Franciscus Theresius Maria Van Asten
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Publication number: 20120100185Abstract: The present invention provides methods and compositions for tissue regeneration without cell transplantation.Type: ApplicationFiled: April 13, 2010Publication date: April 26, 2012Inventors: Xuejun Wen, Yongzhi Qiu, Wendy S. Vanden Berg-Foels
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Patent number: 8158754Abstract: Disclosed is a kind of multiple modified derivatives of gelatin having not only the structure of formula (I) but also one of structures of formula (II), (III), and (IV) as well, wherein, G refers to gelatin residue, which can be type A, type B or a gelatin obtained from gene recombination; R1 refers to alkylene, or a linkage group with amide; R2 refers to alkyl, or aryl; R3 refers to alkylene; and R4 refers to carboxyl or carboxylate. The multiple modifying ways of gelatin comprise the hydrophobic modification on the amino group of gelatin through amide bond, carboxylation on the amino group of gelatin through amide bond, thiolation on the carboxyl group of gelatin, and thiolation following carboxylation on amino group of gelatin through amide bond. Also disclosed is a crosslinked material made of multiple modified derivatives of gelatin. The multiple modified derivatives of gelatin have flexible chemical structures and many properties.Type: GrantFiled: September 29, 2007Date of Patent: April 17, 2012Assignee: Bioregen Biomedical (Changzhou) Co., Ltd.Inventor: Chan Song
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Patent number: 8158755Abstract: A method of producing gelatin particles, including immersing a discharge spout in a hydrophobic solvent, discharging an aqueous gelatin solution from a nozzle tip into the hydrophobic solvent, and lifting, after discharging, the nozzle from the hydrophobic solvent, which can produce particles having an object particle size in a high yield, and can produce gelatin particles that do not essentially require a classification operation.Type: GrantFiled: September 25, 2009Date of Patent: April 17, 2012Assignee: Nitto Denko CorporationInventors: Eriko Konno, Tatsumi Ishikawa, Tsuyoshi Kasahara
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Publication number: 20120070375Abstract: There is provided a gelatin-ICG complex that can suppress leakage of ICG included therein. The complex has a gelatin derivative including at least one of a phospholipid covalently bonded to a gelatin or a cholesterol covalently bonded to a gelatin, and indocyanine green.Type: ApplicationFiled: August 15, 2011Publication date: March 22, 2012Applicant: CANON KABUSHIKI KAISHAInventors: Yasuhiko Tabata, Masato Minami, Yoshinori Tomida, Satoshi Yuasa, Tetsuya Yano, Jun-ichiro Jo, Mie Morita
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Publication number: 20120052042Abstract: The present disclosure relates to amphiphilic compounds, self assembling compositions formed from the amphiphilic compounds and methods of making such compositions.Type: ApplicationFiled: February 22, 2010Publication date: March 1, 2012Inventors: Sébastien Ladet, Philippe Gravagna
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Patent number: 8124757Abstract: The disclosed is thiol-modified macromolecule derivatives having the general formula of (I) or (II), as well as the disulfide bond cross-linked materials and the thiol-reactive crosslinker cross-linked materials, wherein R1 and R2 are alkylene groups, substituted alkylene groups, aromatic groups or polyether groups and the like, respectively. R1 and R2 may have same or different chemical structure, and P is a residue of a macromolecule with side carboxyl group. The thiol-modified macromolecule derivative has a molecular weight of from 1000 to 5,000,000. The thiol-modified macromolecule derivative having the general formula of (I) or (II) of the present invention has a side chain with flexible chemical structure and adjustable properties, and has a number of advantages, such as mild reaction condition, high production yield, high degree of modifying, and the controllable modifying degree and so on.Type: GrantFiled: September 29, 2007Date of Patent: February 28, 2012Assignee: Bioregen Biomedical (Changzhou) Co., Ltd.Inventor: Chan Song
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Coenzyme Q10 Nanoparticles, Preparation Method Thereof and Composition Containing Said Nanoparticles
Publication number: 20120041178Abstract: Provided are a coenzyme Q10 nanoparticle, a method of preparing the same and a composition having the nanoparticle. According to the present invention, Coenzyme Q10 may be dissolved in only a water-miscible organic solvent, and easily made into a nano-sized particle and solubilized under a low energy condition, for example, by simple stirring. The coenzyme Q10 may be dispersion-stabilized by an amino acid or protein. The coenzyme Q10 is formed in a nano-sized particle and solubilized, an absorption rate may be increased and simultaneously deliver the amino acid and protein with the nanoparticle. Thus, the coenzyme Q10 nanoparticle can be effectively used in food, cosmetics and medicine.Type: ApplicationFiled: April 6, 2010Publication date: February 16, 2012Applicant: Korea Research Institute of Bioscience and BiotechnologyInventors: Bong Hyun Chung, Jung Hyun Han -
Publication number: 20120035321Abstract: The present disclosure relates to compounds and medical devices activated with a solvophobic material functionalized with a first reactive member and methods of making such compounds and devices.Type: ApplicationFiled: February 22, 2010Publication date: February 9, 2012Inventors: Sébastien Ladet, Philippe Gravagna
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Publication number: 20110283918Abstract: The invention concerns lake compositions based on natural macromolecules (gelatin, chitosan, pectine etc.) with possible additions of vinyl polymers, metal-alcoxides etc., characterized by a barrier effect modulated in situ, in particular as a function of the relative humidity in the exterior ambient.Type: ApplicationFiled: January 25, 2010Publication date: November 24, 2011Inventors: Stefano Farris, Luciano Piergiovanni, Giovanni Ronchi, Roberto Rocca, Laura Introzzi
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Publication number: 20110280914Abstract: Described herein are composites useful in tissue and organ engineering. In one aspect, the composite comprises the reaction product between a macromolecule comprising at least one thiol group and a gold nanoparticle. The thiolated macro-molecule crosslinks with the gold nanoparticle to produce a composite that is useful in anchoring cells. The composites can be used to form multi-layer 3-D structures, where the cells in each layer can aggregate and fuse with one another to form tissues and organs.Type: ApplicationFiled: December 17, 2009Publication date: November 17, 2011Applicant: University of Utah Research FoundationInventors: Glenn D. Prestwich, Aleksander Skardel, Jianxing Zhang
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Patent number: 8048446Abstract: Non-woven fibrous scaffolds made by electrospinning from the synthetic biodegradable polymer such as, for example, poly(lactic-co-glycolic acid) (PLGA) and natural proteins, such as, for example, gelatin (denatured collagen) and elastin and a method of making thereof.Type: GrantFiled: May 10, 2006Date of Patent: November 1, 2011Assignee: Drexel UniversityInventors: Peter I. Lelkes, Mengyan Li, Mark Mondrinos, Frank Ko
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Publication number: 20110256222Abstract: The invention relates to a recombinant protein enriched in a heparin binding site and/or a heparan sulfate binding site. Such recombinant protein is used as an in vivo controlled release system of a protein of interest.Type: ApplicationFiled: April 7, 2009Publication date: October 20, 2011Inventors: Arjo Lysander De Boer, Jan Bastiaan Bouwstra
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Publication number: 20110256303Abstract: A process for cross-linking proteins, according to which the crosslinking agent is dihydroxyacetone and the proteins are chosen from proteins from animal tissues, from milk or from blood, such as in particular casein, gelatin or collagen; proteins from cereals, such as in particular maize, wheat or rice proteins; protein from high-protein plants, such as in particular pea, alfalfa, lupin, barley, millet or sorghum proteins; proteins from oleaginous plants, such as in particular soybean proteins, for instance soybean cakes, rapeseed or flax proteins, for instance rapeseed cakes, sunflower, groundnut or cotton proteins; and proteins from tubers, such as in particular from potato or manioc.Type: ApplicationFiled: June 27, 2011Publication date: October 20, 2011Applicant: ROQUETTE FRERESInventors: Daniel WILS, Catherine FOUACHE
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Publication number: 20110177316Abstract: The invention relates to a method for producing a biodegradable molded part, comprising: providing a binding agent which contains a lyzable biopolymer; forming a molded part from the binding agent, wherein the time stability of the molded part to biological lysis is set by at least one of the following measures: adding a pulverized inorganic solid matter in a proportion of 5% to 85% of the mass of the binding agent before forming the molded part; thawing at least one of the surfaces of the molded part using a chemical or biological method such that the surface has a structuring in the range between 1 nm and 10 ?m. The invention further relates to an accordingly produced molded part.Type: ApplicationFiled: October 3, 2008Publication date: July 21, 2011Applicant: LEONARDIS-STIFTUNGInventors: Klaus Rennebeck, Bernd Hildenbrand
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Publication number: 20110125089Abstract: Provided herein are hemostatic compositions. In one embodiment, the hemostatic composition includes cross-linked polymer microspheres, such as cross-linked gelatin microspheres with pores. In another embodiment, the hemostatic composition comprises an additive such as a wetting agent, a suspending agent, or both. The hemostatic compositions may also include a hemostatic agent such as thrombin, and may include a high concentration of thrombin. The hemostatic compositions may also include plasma. Also provided herein are devices for dispersing said hemostatic compositions in a diluent, and delivering said dispersed hemostatic composition. The hemostatic compositions may also fabricated with a selected geometry as administration suggests.Type: ApplicationFiled: March 26, 2009Publication date: May 26, 2011Applicant: ZYMOGENETICS, INC.Inventors: Richard I. Senderoff, Jeffrey D. Meyer, Emily N. Rollins, Steven D. Hughes, Richard M. Garcoa, Paul D. Bishop, Gerald W. Lasser
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Patent number: 7928069Abstract: Described herein are crosslinked compounds useful in numerous treatments. Described herein are methods of making crosslinked compounds via (1) die oxidative coupling of two or more thiol compounds or (2) by the reaction between at least one thiol compound with at least one thiol-reactive compound.Type: GrantFiled: October 2, 2008Date of Patent: April 19, 2011Assignee: University of Utah Research FoundationInventors: Glenn D. Prestwich, Xiao Zheng Shu, Yi Luo, Kelly R. Kirker, Yanchun Liu
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Patent number: 7923031Abstract: The present invention is directed to a powder delivery system containing a composition comprising gelatin or collagen powder having a mean particle size of at least 10 ?m. The gelatin or collagen powder is typically in dry form, i.e. no liquid components and/or propellants are added to the composition. The present invention is also directed to an improved powder delivery system which contains a protective structure, such as a skirt, located close to the orifice of the delivery system. In a further aspect, the present invention is directed to gelatin- or collagen-based compositions useful in hemostatic applications. In a further aspect of the invention the powder delivery system comprises gelatin or collagen powder in a dry form ready to use. Further the powder delivery system in a dry form might comprise an agent incompatible with moisture and/or water.Type: GrantFiled: January 28, 2005Date of Patent: April 12, 2011Assignee: Ferrosan Medical Devices A/SInventor: Lene Møller
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Patent number: 7897728Abstract: The present invention provides a process to make a gelatine hydrolysate, a gelatine hydrolysate, and gelatine compositions including gelatine hydrolysates. More specifically, the invention provides gelatine compositions having a reduced tendency to cross-link and improved dissolution properties.Type: GrantFiled: May 31, 2006Date of Patent: March 1, 2011Assignee: Gelita AGInventors: John M. Dolphin, Jason D. Russell
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Publication number: 20110044928Abstract: The present invention provides a film composition effective for correcting irregularities on the skin surface, which has stretchability and flexibility as a result of crosslinkable protein microparticles in the film composition being crosslinked by transglutaminase, as well as superior air permeability and moisture evaporation properties as a result of forming a film with the crosslinkable protein microparticles.Type: ApplicationFiled: January 14, 2009Publication date: February 24, 2011Inventors: Haruma Kawaguachi, Akiko Sudo, Yuichiro Mori, Katsuhiko Yagi, Takashi Oka
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Publication number: 20110038828Abstract: A method of treating a disorder characterized by tissue damage is provided. The method comprising providing to a subject in need-thereof a composition which comprises a synthetic polymer attached to denatured fibrinogen or a therapeutic portion of the fibrinogen, the composition being formulated for releasing the therapeutic portion of the fibrinogen in a pharmacokinetically regulated manner, thereby treating the disorder characterized by tissue damage or malformation.Type: ApplicationFiled: October 27, 2010Publication date: February 17, 2011Applicant: REGENTIS BIOMATERIALS LTD.Inventors: DROR SELIKTAR, LIORA ALMANY
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Publication number: 20110020649Abstract: An immobilization method for immobilizing a physiologically active substance on a solid phase carrier, the method including: bringing the solid phase carrier into contact with an acid anhydride functional group-containing silane coupling agent represented by the following Formula (I); and carrying out a process of binding of the physiologically active substance to the acid anhydride functional group while maintaining the solid phase carrier after the contact at a temperature within the range of 0° C. to 60° C.; a physiologically active substance-immobilized carrier, and a carrier for immobilization are provided. Further, a carrier including a porous material treated with an acid anhydride functional group-containing silane coupling agent represented by the following Formula (I), a blocking agent that is immobilized to the porous material; and a method for producing it is provided.Type: ApplicationFiled: March 13, 2009Publication date: January 27, 2011Applicant: FUJIFILM CORPORATIONInventors: Morihito Ikeda, Taisei Nishimi, Junichi Katada
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Publication number: 20110009327Abstract: The present invention relates to a porous inorganic/organic hybrid nanoscale composite comprising an enzymatically biodegradable organic polymer and a sol-gel derived silica network, its production and use as a macroporous scaffold in tissue engineering.Type: ApplicationFiled: September 5, 2008Publication date: January 13, 2011Applicant: IMPERIAL INNOVATIONS LIMITEDInventors: Robert Graham Hill, Gowsihan Poologasundarampillai, Julian R. Jones
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Publication number: 20100330143Abstract: Described herein are composites produced by reacting a first thiolated macromolecule with at least one compound having at least one thiol-reactive electrophilic functional group. The methods described herein permit the cross-linking of a variety of different thiolated macromolecules with one another. The composites described herein have a variety of biomedical and pharmaceutical applications, which are also described herein.Type: ApplicationFiled: April 21, 2010Publication date: December 30, 2010Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATIONInventors: Glenn D. Prestwich, Aleksander Skardal, Jianxing Zhang
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Publication number: 20100323421Abstract: It is an object of the present invention to provide a method for chemically modifying biopolymer and polypeptide with a hydrophobic compound or a compound which causes degradation or reaction under basic condition. The present invention provides a method for producing a chemically modified biopolymer or polypeptide, wherein a biopolymer or polypeptide is chemically modified in a reaction solution containing an organic fluorine compound.Type: ApplicationFiled: November 28, 2008Publication date: December 23, 2010Applicant: FUJIFILM CorporationInventors: Shouji Ooya, Tetsuo Hiratou, Kentaro Nakamura
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Patent number: 7855273Abstract: A method of manufacturing gelatin with reduced endotoxin content. The method comprises processing a starting material gelatin-containing solution containing gelatin and an endotoxin with an ultrafiltration film having a molecular weight cut-off falling within a range of from 20,000 to 300,000 and having a molecular weight cut-off capable of passing at least a portion of the gelatin contained in the starting material gelatin-containing solution to obtain a permeate that is a gelatin-containing solution with a reduced endotoxin content. A gelatin having an average molecular weight falling within a range of 1,000 to 300,000 and an endotoxin content of less than 1 EU/mL per 1.0 percent of protein.Type: GrantFiled: March 2, 2007Date of Patent: December 21, 2010Assignee: Jellice Co., Ltd.Inventors: Yoshitaka Kanayama, Yasuo Sakai
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Publication number: 20100261136Abstract: The invention relates to a dental composition comprising a hardenable powder to be used in a process for retraction of dental tissue. The invention also relates to a kit of parts comprising the dental composition comprising a hardenable powder, a hardening agent, optionally a handpiece of a powder jet device, optionally a powder jet device, and optionally retraction caps. In a further aspect, the invention relates to a method for retracting dental tissue comprising the steps of applying a dental composition comprising a hardenable powder with a powder jet device into the sulcus between soft and hard dental tissue, applying a composition comprising a hardening agent either before or after the previous step, leaving the dental composition in the sulcus for a time sufficient to effect retraction of the soft dental tissue and removing the dental composition from the sulcus.Type: ApplicationFiled: December 9, 2008Publication date: October 14, 2010Inventors: Christoph Schulte, Andreas R. Maurer, Thomas Klettke, Ruediger Hampe, Ingo R. Haeberlein
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Patent number: 7758895Abstract: The present invention provides methods for purifying insoluble bone gelatin and uses for insoluble bone gelatin. The process for isolating insoluble bone gelatin from bone tissue includes grinding the bone tissue into bone powder; washing the bone powder with saline; demineralizing the bone tissue; contacting the bone powder with a neutral salt; and contacting the bone powder with a stabilizer. The present invention also discloses an insoluble bone gelatin including about 10 percent growth factor. Insoluble bone gelatin is useful, for example, in preparing impaction bone grafts.Type: GrantFiled: September 4, 2002Date of Patent: July 20, 2010Assignee: Perth Bone and Tissue BankInventors: Ying Fan, Ming Hao Zheng, David Wood
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Publication number: 20100160467Abstract: Provided are an organic-inorganic hybrid scaffold with surface-immobilized nano-hydroxyapatite, and a method for the fabrication thereof. The scaffold is fabricated by reacting an acid group present on a surface of nano-hydroxyapatite with a primary amine present on a surface of a polymer support in the presence of EDC (1-ethyl-3-dimethylaminopropyl carbodiimide) to immobilize nano-hydroxyapatite onto the surface of the polymer support. The surface of nano-hydroxyapatite is previously grafted with poly(ethylene glycol methacrylate phosphate) (PolyEGMP) having phosphonic acid functionality or with a polymer having carboxylic acid functionality.Type: ApplicationFiled: December 10, 2009Publication date: June 24, 2010Applicant: KOREA INSTITUTE OF CERAMIC ENGINEERING & TECHNOLOGYInventors: Sang Cheon Lee, Jeong Ho Chang, Jin Hyung Lee, Kyung Ja Kim, Sung Eun Kim, Ho Chan Hwang, Ke-Won Kang, Seog-Jin Seo, Jin-Young Kim
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Publication number: 20100152423Abstract: The disclosed is thiol-modified macromolecule derivatives having the general formula of (I) or (II), as well as the disulfide bond cross-linked materials and the thiol-reactive crosslinker cross-linked materials, wherein R1 and R2 are alkylene groups, substituted alkylene groups, aromatic groups or polyether groups and the like, respectively. R1 and R2 may have same or different chemical structure, and P is a residue of a macromolecule with side carboxyl group. The thiol-modified macromolecule derivative has a molecular weight of from 1000 to 5,000,000. The thiol-modified macromolecule derivative having the general formula of (I) or (II) of the present invention has a side chain with flexible chemical structure and adjustable properties, and has a number of advantages, such as mild reaction condition, high production yield, high degree of modifying, and the controllable modifying degree and so on.Type: ApplicationFiled: September 29, 2007Publication date: June 17, 2010Applicant: Bioregen Biomedical (Changzhou) Co., Ltd.Inventor: Chan Song
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Publication number: 20100119574Abstract: The invention concerns a recombinant CBE gelatin and recombinant gelatins having multimers of the CBE monomer sequence that are of particular use in several applications involving cell attachment such as in cell culture work and applications involving cell cultures of anchor dependent cells and also in a variety of medical applications.Type: ApplicationFiled: February 21, 2008Publication date: May 13, 2010Inventors: Arjo Lysander De Boer, Hendrik Van Urk, Jan Bastiaan Bouwstra, Peter Franciscus Theresius Maria Van Asten
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Publication number: 20100105618Abstract: The invention concerns recombinant gelatin monomers and recombinant gelatins comprising or consisting of multimers of the monomers. The recombinant gelatins can be produced with enhanced stability.Type: ApplicationFiled: February 21, 2008Publication date: April 29, 2010Inventors: Arjo Lysander De Boer, Hendrik Van Urk, Jan Bastiaan Bouwstra, Peter Franciscus Theresius Maria Van Asten
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Patent number: 7700660Abstract: The invention provides a method of treating a chronic ulcer, such as a diabetic ulcer, comprising administering a therapeutic amount of a hydrogel matrix to the ulcer, the matrix composition comprising gelatin and a long chain carbohydrate. The matrix may further include polar amino acids, nitric oxide inhibitors and super oxide inhibitors. Injection is a preferred method of administration. The matrix may be injected into one or more locations within the ulcer, underneath the ulcer and/or around the periphery of the ulcer.Type: GrantFiled: May 30, 2001Date of Patent: April 20, 2010Assignee: Encelle, Inc.Inventor: Anton-Lewis Usala
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Publication number: 20100092778Abstract: A method is provided for producing particles which is capable of producing particles in simple and easy steps. The objective is to provide with a high yield particles having a homogeneous particle diameter and a superior dispersibility in liquid. The method includes (1) preparing an aqueous solution containing one or more polymer; and (2) introducing the aqueous solution as droplets into a solvent capable of dissolving water by 1 mass % or more and less than 50 mass % to form the polymer into dispersed particles in the mixture of the aqueous solution and the solvent in the mixture of the aqueous solution and the solvent.Type: ApplicationFiled: November 22, 2007Publication date: April 15, 2010Applicants: CANON KABUSHIKI KAISHA, MEDGEL CORPORATIONInventors: Kohei Watanabe, Takeshi Miyazaki, Yasuhiko Tabata
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Publication number: 20100087626Abstract: It is an object of the present invention to provide a method wherein a structure which was prepared with a biopolymer such as gelatin is chemically modified with the use of a low-volatile chemical substance without dissolution of gelatin, and a biopolymer crosslinking method for producing a biopolymer having high strength (a high degree of crosslinking). The present invention provides a method for producing a modified biopolymer, which comprises reacting a structure prepared with a biopolymer with a solid-state compound having a melting point of 50° C. or more at a humidity of 50% or more, and a method for crosslinking biopolymer which comprises treating a biopolymer with a crosslinking agent, wherein the crosslinking agent concentration in a reaction mixture is 1.0% to 10% by weight and crosslinking is carried out in the presence of an organic fluorine compound.Type: ApplicationFiled: December 13, 2007Publication date: April 8, 2010Inventors: Shouji Ooya, Tetsuo Hirataou
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Publication number: 20100075392Abstract: An object of the present invention is to provide a method for efficiently removing a residual organic solvent in a biopolymer structure. The present invention provides a method for removing an organic solvent contained in a biopolymer structure from the structure, (1) wherein the structure is placed in an atmosphere containing a solvent other than the organic solvent so as to remove the organic solvent, or (2) wherein the organic solvent is removed by washing the structure with a solution mainly containing water, or (3) wherein the structure contains a hydrophilic compound.Type: ApplicationFiled: November 21, 2007Publication date: March 25, 2010Applicant: FUJIFLIM CORPORATIONInventors: Shouji Ooya, Tetsuo Hiratou
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Publication number: 20100075902Abstract: The invention concerns recombinant gelatin monomers and recombinant gelatins comprising or consisting of multimers of the monomers. The recombinant gelatins are of particular use in several applications involving cell attachment such as in cell culture work and applications involving cell cultures of anchor dependent cells and also in a variety of medical applications.Type: ApplicationFiled: February 21, 2008Publication date: March 25, 2010Inventors: Arjo Lysander De Boer, Hendrik Van Urk, Jan Bastiaan Bouwstra, Peter Franciscus Theresius Maria Van Asten
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Publication number: 20100062531Abstract: The invention concerns recombinant gelatins with unevenly distributed RGD motifs that are of particular use in several applications involving cell attachment such as in cell culture work and applications involving cell cultures of anchor dependent cells and also in a variety of medical applications.Type: ApplicationFiled: February 21, 2008Publication date: March 11, 2010Inventors: Arjo Lysander De Boer, Hendrik Van Urk, Jan Bastiaan Bouwstra, Peter Franciscus Theresius Maria Van Asten
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Publication number: 20100056452Abstract: To provide an angiogenesis-promoting substrate which can be easily and cost-effectively produced, it is proposed that the substrate comprise a non-porous shaped body formed from a gelatin-containing material which is insoluble and resorbable under physiological conditions.Type: ApplicationFiled: November 10, 2009Publication date: March 4, 2010Applicant: GELITA AGInventors: Michael Ahlers, Burkhard Schlosshauer, Lars Dreesmann
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Publication number: 20100055184Abstract: The present invention provides hydrogels and compositions thereof for vocal cord repair or augmentation, as well as other soft tissue repair or augmentation (e.g., bladder neck augmentation, dermal fillers, breast implants, intervertebral disks, muscle-mass). The hydrogels or compositions thereof are injected into the superficial lamina propria or phonatory epithelium to restore the phonatory mucosa of the vocal cords, thereby restoring a patient's voice. In particular, it has been discovered that hydrogels with an elastic shear modulus of approximately 25 Pa are useful in restoring the pliability of the phonatory mucosa. The invention also provides methods of preparing and using the inventive hydrogels.Type: ApplicationFiled: September 3, 2009Publication date: March 4, 2010Inventors: Steven M. Zeitels, Robert Edward Hillman, Sandeep Sidram Karajanagi, Robert S. Langer
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Patent number: 7659372Abstract: Menstrual fluid simulants may consistently emulate the physical characteristics of real menstrual fluid, including but not limited to, viscosity, stringiness, surface tension and size and concentration of particulate matter. In addition, the constituents comprising the menstrual fluid simulants may be changed in order to mimic the variations in real menstrual fluid observed from woman to woman and from an individual woman over time. The menstrual fluid simulants are of use in the testing of personal care absorbent products.Type: GrantFiled: April 19, 2006Date of Patent: February 9, 2010Assignee: The Procter & Gamble CompanyInventors: William Hollis Hood, Marsha Jean Spears, William Joseph Worley
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Publication number: 20100029908Abstract: An absorbable sponge containing a contrasting agent (e.g., radiopaque agent) that can be introduced to a biopsy tract or other puncture wound site is provided. The contrasting agent permits identification of the site by fluoroscopy or other imaging techniques.Type: ApplicationFiled: October 13, 2009Publication date: February 4, 2010Applicant: BOSTON SCIENTIFIC SCIMED, INC.Inventors: Eduardo Chi Sing, Mark Ashby
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Publication number: 20100008989Abstract: A process for the preparation of gelatin solutions which is less than a physiologically relevant temperature, which is preferably less than about 37° C., the process comprising adding one or more transition point reducing agents, such as hydrogen bond breakers, reducing agents, plasticizers, surfactants, metal ions or denaturants (denaturing agents), to the gelatin solution. The reduced temperature processing can reduce damage to thermo sensitive pharmaceuticals ingredients or vitamins, or other heat sensitive ingredients.Type: ApplicationFiled: June 12, 2009Publication date: January 14, 2010Inventors: Ishay Attar, Orahn Preiss-Bloom
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Publication number: 20090306345Abstract: The disclosed is a kind of multiple modified derivatives of gelatin having not only the structure of formula (I) but also one of structures of formula (II), (III), and (IV) as well. Wherein, G refers to gelatin residue comprising type A, type B and the type of gene recombination; R1 refers to alkylene, or a linkage group with amide; R2 refers to alkyl, or aryl; R3 refers to alkylene; R4 refers to carboxyl or carboxylate. The multiple modifying ways of gelatin comprise the hydrophobic modification on the amino group of gelatin through amide bond, carboxylation on the amino group of gelatin through amide bond, thiolation on the carboxyl group of gelatin, and thiolation following carboxylation on amino group of gelatin through amide bond. In addition, the invention also discloses the crosslinked material made of multiple modified derivatives of gelatin. The multiple modified derivatives of gelatin have flexible chemical structures and many properties.Type: ApplicationFiled: September 29, 2007Publication date: December 10, 2009Inventor: Chan Song
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Publication number: 20090269421Abstract: It is an object of the present invention to provide a coating material for a biomedical material surface which can control cell adhesiveness/non-cell adhesiveness and improve the biocompatibility of a material surface. The present invention provides a coating material for a surface of a biomedical material, which comprises a recombinant gelatin.Type: ApplicationFiled: June 27, 2008Publication date: October 29, 2009Applicant: FUJIFILM CorporationInventor: Shouji Ooya
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Patent number: 7605231Abstract: The present invention relates to a gelatin derivative having an organic compound as a graft chain and a high-molecular weight micelle containing the gelatin derivative. As the organic compound, a low molecular weight compound such as succinic acid, ethylenediamine, etc., or a high-molecular weight compound such as polyethylene glycol, polylactic acid, etc. can be used. The high-molecular weight micelle can be used as a pharmaceutical composition excellent in control of sustained release or targeting property by carrying it on a drug, etc. Also, the gelatin derivative can be an excellent adhesion preventing membrane by crosslinking it.Type: GrantFiled: October 25, 2004Date of Patent: October 20, 2009Assignees: NOF CorporationInventors: Yasuhiko Tabata, Koji Sakaguchi, Shinji Tanaka
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Publication number: 20090246282Abstract: The present invention relates to cell carrier particles prepared from recombinantly produced gelatins comprising at least two outer lysine residues which are separated by at least 25 percent of the total number of amino acids in the recombinant gelatin polypeptide. The invention is also directed at applications in which such cell carriers are used, for example as injectable cell carrier, for tissue augentation or cosmetic surgery or as microcarrier in in vitro cell cultivation.Type: ApplicationFiled: December 22, 2006Publication date: October 1, 2009Inventors: Sebastianus Gerardus Johannes Maria Kluijtmans, Bouwstra Jan Bastiaan