Abstract: Methods and compositions are provided for the recombinant synthesis of the tumor growth factor-.alpha. precursor and its fragments. These are useful in therapy and diagnosis, as are antibodies raised by immunization with the tumor growth factor-.alpha. precursor and its fragment.

Abstract: A selective method of suppressing the growth of cells which express a viral antigen on the surface thereof, which comprises administering to the cells a growth suppressing amount of a monoclonal antibody against said viral antigen, especially a method of suppressing the growth of hepatocytes or hepatoma cells persistently infected with HBsAg which comprises administering to the cells a growth suppressing or lethal amount of a complement fixing monoclonal IgM or IgG.sub.2a antibody against HBsAg.

Abstract: A substantially purified substance having the property of inhibiting tumor cell growth without inhibiting the growth of normal human cells and without having antiviral effect, further having the properties of: (a) ranging from about 3,500 to 45,000 daltons in molecular weight; (b) being heat stable at about 56.degree. C. when exposed for about 30 minutes; (c) possessing isoelectric point ranging from pI 4-8; and (d) eluting on high pressure liquid chromatography at about 10-35% of 2-propanol or about 25-50% of acetonitrile gradient, has been disclosed. The substance has utility as an antitumor or antineoplastic agent. The substance may also be useful as an index or tumorgenic activity in an organism. The mitogenic and growth stimulatory activity possessed by the substance of the present invention may be useful in wound healing and treating burn-victims.

Abstract: Methods and compositions for detecting the presence of tumors are provided, where a physiological sample is assayed for the expression product of a c-onc gene as diagnostic for the presence of the tumor. The method finds use in both pre- and postoperative situations with a host suspected of having transformed malignant cells.

Abstract: Interleukin-2 dependent cytotoxic cultured T-cell lines are found to produce .alpha., .beta., and .gamma. interferon, as well as interleukin-2, when stimulated by mitogenic or antigenic agents.

Abstract: According to the present invention there is provided an essentially pure protein found in nature in mast cells and in basophiles, which protein is involved in the transfer of calcium into such cells. Such a protein has an isoelectric point of about 3.9 and a MW about 60,000.+-.2,000, and has an amino acid composition as herein defined. There are also provided processes for the preparation of such purified protein. Such protein is of use in blocking histamine release from cells.

Abstract: Bifunctional derivatives of a 3-carboxhydrazide of an antineoplastic dimeric indole-dihydroindole alkaloids, useful both in forming conjugates with immunoglobulins and as anti-tumor agents.

Abstract: A method is described for the covalent attachment of linker groups to specific sites on antibody molecules directed against any desired target antigen (tumor, bacterial, fungal, viral, parasitic etc.). These linkers can be attached via amide or ester bonds to compounds for delivery which contain available amino or hydroxy groups (e.g., bioactive agents, cytotoxic agents, dyes, fluors, radioactive compounds, etc.). In addition the linkers can be incorporated into insoluble matrices for use in separation schemes which are based upon antibody-antigen interactions.The linkers may be designed so that they are susceptible to cleavage by any one of the serum complement enzymes. When prepared according to the methods described herein, the resulting modified antibody molecule retains the ability to bind antigen and to fix serum complement. Thus, when administered to a patient the antibody conjugate binds to its target in vivo.

Abstract: An antineoplastic dimeric indole-dihydroindole (vinca) alkaloid carrying a hydrazine succinimide group at C-3, capable of forming conjugates with a diacid at C-4.

Abstract: The present invention provides an interleukin-2 composition which comprises human serum albumin, a reducing compound or a combination thereof and is adjusted as showing pH of 3 to 6 as a solution. The composition of the present invention is characterized in that interleukin-2 activity is minimized during storage and in the processes of freezing and lyophilization.