Chalcogen Or Additional Nitrogen Bonded Directly To The Diazoamino Group Patents (Class 534/552)
-
Patent number: 9063160Abstract: Amount of combined nitric oxide or nitric oxide present as iron nitrosyls in a blood sample is determined by directing a low power electromagnetic radiation beam at a blood sample to liberate nitric oxide gas, dissolving the liberated nitric oxide gas and electrochemically detecting amount of dissolved nitric oxide gas.Type: GrantFiled: July 15, 2008Date of Patent: June 23, 2015Assignee: Duke UniversityInventors: Jonathan S. Stamler, Michael Angelo
-
Publication number: 20150141378Abstract: Described herein are nitroxyl progenitor compounds, and compositions including, and methods or generating, the compounds thereof, and methods of treating or preventing disease and disease symptoms using the compounds and compositions.Type: ApplicationFiled: September 22, 2014Publication date: May 21, 2015Inventors: John P. Toscano, Christopher M. Pavlos, Preeya Kapur Boppana
-
Patent number: 8933208Abstract: The purpose of the present invention is to provide novel liquid crystalline compounds that are capable of inducing phase transition by a light stimulus and are useful in the display, optoelectronics, and photonics field. The present invention relates to the liquid crystalline compounds represented by general formula (1): wherein R1, R2 and R3 are independently selected from the group consisting of hydrogen, alkyl, alkoxyl, alkoxycarbonyl, alkoxycarbonyloxy, alkanoyl, alkanoyloxy, alkoxyphenyl, and N-alkylaminocarbonyl, and n is an integer.Type: GrantFiled: May 10, 2011Date of Patent: January 13, 2015Assignee: National Institute of Advanced Industrial Science and TechnologyInventors: Yasuo Norikane, Yuki Hirai, Masaru Yoshida
-
Publication number: 20140171395Abstract: Provided here are nitric oxide-releasing compounds that include at least two different NO donor functional groups of the same class. In some embodiments, such nitric oxide-releasing compounds are macromolecules such as dendrimer and co-condensed silica. Pharmaceutical compositions, wound dressings, kits and methods of treatments are also provided herein.Type: ApplicationFiled: February 19, 2014Publication date: June 19, 2014Applicants: The University of North Carolina at Chapel Hill, Novan, Inc.Inventors: Mark Schoenfisch, Yuan Lu, Nathan Stasko, Jian Bao
-
Publication number: 20140135295Abstract: A compound of Formula (I): or a pharmaceutically acceptable salt of the compound. Also described are pharmaceutical formulations thereof and methods of using the same.Type: ApplicationFiled: November 8, 2013Publication date: May 15, 2014Applicant: IRONWOOD PHARMACEUTICALSInventors: Jeffrey Segal, Nisha Perez, Timothy Claude Barden
-
Publication number: 20140088048Abstract: A compound having the structure or a pharmaceutically acceptable salt thereof, wherein R6 is hydrogen, —OH, —C1-6alkyl, —OC1-6alkyl, aryl, or halogen, or together with R7, forms an oxo group, or together with R7 and the atom to which they are attached, form a 5-7-membered carbocycle ring or a 5-7-membered heterocyclic ring having 1, 2, or 3 heteroatoms, wherein alkyl and aryl are unsubstituted or independently mono-, di-, or tri-substituted with R14; R7 is hydrogen, C1-6alkyl, —CF3, aryl, —O-aryl, —O—C1-6alkyl, —C(O)OC1-6alkyl, —C(R15R16)OH, a 5-7-membered heteroaryl having 1, 2, 3 or 4 nitrogen atoms, or halogen, or together with R6, forms an oxo group, or together with R6 and the atom to which they are attached, form a 5-7-membered carbocycle ring or a 5-7-membered heterocyclic ring having 1, 2, or 3 heteroatoms wherein alkyl, aryl and heteroaryl are unsubstituted or independently mono-, di- or tri-substituted with R14; R12 is hydrogen, C1-6alkyl, or —(CH2)1-2OH, or together with R13 and the nitrType: ApplicationFiled: April 27, 2012Publication date: March 27, 2014Applicant: Merck Sharp & Dohme Corp.Inventors: Amjad Ali, Michael Man-Chu Lo, Lin Yan
-
Patent number: 8648058Abstract: A compound of formula I, wherein R1-R7 are defined herein, or stereoisomers therof, or pharmaceutically acceptable salts thereof, or pharmaceutically acceptable salts of stereoisomers thereof, and methods of using these compounds for treating hypertension.Type: GrantFiled: February 10, 2011Date of Patent: February 11, 2014Assignee: Merck Sharp & Dohme Corp.Inventors: Amjad Ali, Michael Man-Chu Lo, Edward Metzger, Lin Yan
-
Patent number: 8633177Abstract: Disclosed is a compound of the formula (I) or a pharmaceutically acceptable salt thereof: (I) in which R1, R2, R3, and R4 are defined herein and pharmaceutical compositions thereof. Further provided is a method of treating various disorders, such as a disorder selected from the group consisting of a cardiovascular disorder, cancer, chronic pain, alcohol dependence, and inflammation in a patient comprising administering an effective amount of a compound or pharmaceutically acceptable salt of formula (I).Type: GrantFiled: March 18, 2011Date of Patent: January 21, 2014Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services, The Arizona Board of Regents, on behalf of the University of ArizonaInventors: Katrina M. Miranda, David A. Wink, Debra J. Salmon, Debashree Basudhar, Larry K. Keefer, Joseph E. Saavedra, Daniela Andrei
-
Publication number: 20130302904Abstract: Selective chemosensing agents for hydrogen sulfide are provided. The chemosensing agents can act fast under mild conditions, are chemically stable for long-term storage, are sensitive for detection under near physiological conditions, show a linear concentration-signal relationship within physiologically relevant hydrogen sulfide concentration ranges for easy quantitation, show minimal or no interference by other anions in the blood, and are functional in aqueous solutions and blood plasma.Type: ApplicationFiled: January 6, 2012Publication date: November 14, 2013Applicant: GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.Inventors: Hanjing Peng, Binghe Wang
-
Publication number: 20130065863Abstract: Disclosed is a compound of the formula (I) or a pharmaceutically acceptable salt thereof: (I) in which R1, R2, R3, and R4 are defined herein and pharmaceutical compositions thereof. Further provided is a method of treating various disorders, such as a disorder selected from the group consisting of a cardiovascular disorder, cancer, chronic pain, alcohol dependence, and inflammation in a patient comprising administering an effective amount of a compound or pharmaceutically acceptable salt of formula (I).Type: ApplicationFiled: March 18, 2011Publication date: March 14, 2013Applicants: The Arizona Board of Regents, on behalf of the University of Arizona, Office of Technology Transfer, NIHInventors: Katrina M. Miranda, David A. Wink, Debra J. Salmon, Debashree Basudhar, Larry K. Keefer, Joseph E. Saavedra, Daniela Andrei
-
Publication number: 20130053352Abstract: A compound having the structure or a pharmaceutically acceptable salt thereof, wherein R1 is hydrogen, —OH, —O—C1-6 alkyl, ?O, or halogen; R2 is hydrogen, C(O)OR8, C6H5C(O)OR8, (CH2)1-2OH, CR9R10OH, C(O)O(CH2)0-2 aryl, C(O)NR9R10, C(O)SO2NR9R10, C6H5OR9, W—C(O)OR8, W—OR9, Y, or P(O)(OR9)(ORlO); R3 is hydrogen or —C1-6 alkyl; R4 is hydrogen, —OH or —C(O)OR9; R5 is hydrogen or deuterium; R6 and R7 are independently —C1-6 alkyl, fluoro-substituted —C1-6 alkyl, deutero-substituted —C1-6 alkyl or —(CH2)1-2R11, wherein any carbon atom of the fluoro-substituted —C1-6 alkyl is mono- or di-substituted with fluoro, and any carbon atom of the deutero-substituted —C1-6 alkyl is mono- or di-substituted with fluoro; R8, in each instance in which it occurs, is independently hydrogen, —C1-6 alkyl, or —(CH2)2N+(CH3)3; R9 and R10, in each instance in which they occur, are independently —C1-6 alkyl; R11 is —OH, —O—C1-6 alkyl, -0CD3, —OC(O)OC1-6 alkyl, —NH2, —C6H5, —N3, or W; W is an unsubslituted 5- or 6-raembered heteroaryl riType: ApplicationFiled: February 10, 2011Publication date: February 28, 2013Applicant: MERCK SHARP & DOHME CORP.Inventors: Amjad Ali, Michael Man-Chu Lo, Edward Metzger, Lin Yan
-
Patent number: 8119840Abstract: The present invention relates generally to nitric oxide releasing pharmaceutical compounds. More particularly, the present invention relates to pharmaceutical compositions that release nitric oxide under physiological conditions. In one embodiment, the present invention relates to new chemical compounds—diazeniumdiolates nitric oxide donors—that are based on ethambutol possessing physiological and biomedical activity.Type: GrantFiled: March 3, 2006Date of Patent: February 21, 2012Assignee: The University of AkronInventors: Daniel J. Smith, Marcos Lopez
-
Publication number: 20090281067Abstract: Described herein are nitroxyl progenitor compounds, and compositions including, and methods or generating, the compounds thereof, and methods of treating or preventing disease and disease symptoms using the compounds and compositions.Type: ApplicationFiled: January 28, 2005Publication date: November 12, 2009Applicant: The John Hopkins UniversityInventors: John P. Toscano, III, Christopher M. Pavlos, Preeya Kapur Boppana
-
Publication number: 20090069449Abstract: The present invention relates generally to nitric oxide releasing pharmaceutical compounds. More particularly, the present invention relates to pharmaceutical compositions that release nitric oxide under physiological conditions. In one embodiment, the present invention relates to new chemical compounds—diazeniumdiolates nitric oxide donors—that are based on ethambutol possessing physiological and biomedical activity.Type: ApplicationFiled: March 3, 2006Publication date: March 12, 2009Applicant: THE UNIVERSITY OF AKRONInventors: Daniel J. Smith, Marcos Lopez
-
Patent number: 7122529Abstract: Chemical compounds which release nitric oxide in a controlled manner upon photolysis with light are provided. These compounds are O2-benzyl, O2-naphthylmethyl and O2-naphthylallyl substituted diazeniumdiolates. Also provided are methods of preparing these novel compounds in high chemical yields as well as methods of using these compounds.Type: GrantFiled: July 12, 2002Date of Patent: October 17, 2006Assignee: The Johns Hopkins UniversityInventors: Patrick H. Ruane, John P. Toscano
-
Patent number: 6911433Abstract: Provided are O2-glycosylated 1-substituted diazen-1-ium-1,2-diolates (O2-glycosylated diazeniumdiolates) having the formula: in which R is a saccharide, which is attached to the O2 of the compound by the anomeric carbon of a pyranose ring or a furanose ring.Type: GrantFiled: January 7, 2003Date of Patent: June 28, 2005Assignee: The United States of America as represented by the Department of Health and Human ServicesInventors: Joseph E. Saavedra, Larry K. Keefer, Aloka Srinivasan, Christian Bogdan, William G. Rice, Xinhua Ji
-
Patent number: 5808038Abstract: The present invention is directed to bistriazene compounds, pharmaceutical compositions containing effective anti-cancer amounts of these compounds, a method for treating cancer comprising administering to affected subjects an anti-cancer effective amount of a bistriazene compound, and the use of bistriazene compounds as crosslinking reagents applicable to the synthesis and manipulation of polymeric macromolecules.Type: GrantFiled: September 12, 1994Date of Patent: September 15, 1998Assignee: The United States of America as represented by the Secretary of the Department of Health and Human ServicesInventors: Christopher J. Michejda, Jeffrey J. Blumenstein
-
Patent number: 5731301Abstract: The present invention is directed to bistriazene compounds, pharmaceutical compositions containing effective anti-cancer amounts of these compounds, a method for treating cancer comprising administering to affected subjects an anti-cancer effective amount of a bistriazene compound, and the use of bistriazene compounds as crosslinking reagents applicable to the synthesis and manipulation of polymeric macromolecules.Type: GrantFiled: May 31, 1995Date of Patent: March 24, 1998Assignee: The United States of America as represented by the Department of Health and Human ServicesInventors: Christopher J. Michejda, Jeffrey J. Blumenstein
-
Patent number: 5683668Abstract: The present invention provides a method for the generation of NO gas by exposing zwitterionic polyamine-nitric oxide adducts of the formula RN?N(O)NO.sup.- !(CH.sub.2).sub.x NH.sub.2.sup.+ R', wherein R=C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 aminoalkyl, or cyclohexy, R'=hydrogen or C.sub.1 -C.sub.6 alkyl, and x=2-6, to suitable conditions to effect the release of NO, such as by contact with a mildly acidic solvent or water of neutral or slightly alkaline pH.Type: GrantFiled: February 2, 1996Date of Patent: November 4, 1997Assignee: The United States of America as represented by the Department of Health and Human ServicesInventors: Joseph A. Hrabie, Larry K. Keefer
-
Patent number: 5672593Abstract: The present invention is directed to bistriazene compounds, pharmaceutical compositions containing effective anti-cancer amounts of these compounds, a method for treating cancer comprising administering to affected subjects an anti-cancer effective amount of a bistriazene compound, and the use of bistriazene compounds as crosslinking reagents applicable to the synthesis and manipulation of polymeric macromolecules.Type: GrantFiled: June 28, 1993Date of Patent: September 30, 1997Assignee: The United States of America as represented by the Department of Health and Human ServicesInventors: Christopher J. Michejda, Jeffrey J. Blumenstein
-
Patent number: 5496961Abstract: Organosilicon compounds having Si-bonded hydrogen atoms are reacted with organic compounds having aliphatic multiple bonds in the presence of triazene oxide-transition metal complexes. The triazene oxide-transition metal complexes are activated by heating at temperatures of from 50.degree. C. to 250.degree. C. and/or by irradiation with light.Type: GrantFiled: May 10, 1995Date of Patent: March 5, 1996Assignee: Wacker-Chemie GmbHInventors: Jochen Dauth, Josef Wolferseder, Bernward Deubzer
-
Patent number: 5426200Abstract: Organosiloxanes comprising at least one chemically bonded transition metal complex of Pt, Pd, Rh, Ru, Os or Ir, having a triazene, tetrazene, tetrazdiene, pentazdiene or triazene oxide ligand and are used as hydrosilylation catalysts that can be activated by light and/or heat.Type: GrantFiled: July 19, 1994Date of Patent: June 20, 1995Assignee: Wacker-Chemie GmbHInventors: Jochen Dauth, Udo Peetz, Bernward Deubzer
-
Patent number: 5420254Abstract: A compound of the formula I ##STR1## in which D is a diazo component,K is an aromatic group of formula a, b or c, ##STR2## Y is C.sub.2-3 alkylene and the remaining symbols are as defined in the specification. These compounds are useful for dyeing or printing textile substrates based on synthetic or semisynthetic, hydrophobic, high molecular weight organic materials. Preferably, the textile substrate is made from a linear aromatic polyester, cellulose 21/2 acetate or cellulose tri-acetate. The dyeings and prints obtained show good all round fastness properties such as good thermomigration properties, lightfastness, thermofixation, blistering properties as well as good wet fastness properties, especially after thermal fixation.Type: GrantFiled: October 19, 1993Date of Patent: May 30, 1995Assignee: Sandoz Ltd.Inventors: Ruedi Altermatt, Robert Egli, Beat Henzi
-
Patent number: 5374710Abstract: Chemical derivatives of nitric oxide are provided which are stable indefinitely in oxygen-containing solutions until photolysis, whereupon they release NO. These compounds have the general formulaA--N.sup.+ (O.sup.-)=N--O--B (I)wherein A is typically a nitrogen- or oxygen-containing substituent and B is a group lablie to photolysis. The compounds are stable and inert in oxygenated aqueous solutions, but release NO upon illumination. Given the ease with which the intensity, timing and location of illumination may be controlled, these compounds are particularly useful in investigating the biological effects of NO with much higher spatial or temporal resolution than heretofore possible.Type: GrantFiled: May 26, 1993Date of Patent: December 20, 1994Assignee: Regents of the University of CaliforniaInventors: Roger Y. Tsien, Lewis R. Makings
-
Patent number: 4760174Abstract: Tetralin derivatives of the formula I ##STR1## where X, R.sup.1, R.sup.2 and R.sup.3 have the meanings stated in the description, and their preparation are described. The novel compounds are useful for the treatment of disorders.Type: GrantFiled: September 20, 1985Date of Patent: July 26, 1988Assignee: BASF AktiengesellschaftInventors: Fritz-Frieder Frickel, Hans-Heiner Wuest, Axel Nuerrenbach
-
Patent number: 4678497Abstract: Triazine-substituted azobenzenesulfonamides useful as preemergent and postemergent herbicides, selected from compounds of Formulae I or II ##STR1## or agriculturally suitable salts thereof, wherein R, R.sub.1, R.sub.2, R.sub.3 and A are as defined herein.Type: GrantFiled: January 13, 1986Date of Patent: July 7, 1987Assignee: E. I. Du Pont de Nemours and CompanyInventor: Wallace C. Petersen