Hetero Ring Containing Patents (Class 534/560)
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Patent number: 11066371Abstract: The present disclosure provides a substituted pyridine derivative, which can be used as a bioactive compound for inhibiting stomach cell lines and/or inducing regeneration of damaged stomach lining.Type: GrantFiled: December 29, 2016Date of Patent: July 20, 2021Assignee: UNITED ARAB EMIRATES UNIVERSITYInventors: Hany Abdel Aziz Eldeab, Yaser E. Greish, Sneha Thomas, Sherif M. Karam
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Patent number: 9354371Abstract: Azo compounds represented by formula (1) or (2) (In the formulas, A represents a phenyl group or naphthyl group that has at least 1 substituent. R1-R4 represent a hydrogen atom, lower alkyl group or lower alkoxy group, with at least one of R1-R4 being a lower alkoxy group that has a sulfone group. X represents an optionally substituted amino group, optionally substituted benzoylamino group, optionally substituted phenylamino group, optionally substituted phenyl azo group or optionally substituted naphthotriazole group) and salts thereof.Type: GrantFiled: May 19, 2009Date of Patent: May 31, 2016Assignees: Nippon Kayaku Kabushiki Kaisha, Polatechno Co., Ltd.Inventors: Takuto Nishiguchi, Hiroaki Ohno, Takahiro Higeta, Yuichi Sadamitsu
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Publication number: 20150015931Abstract: This invention relates to electrowetting fluids, the use of these fluids for the preparation of an electrowetting displays devices, and electrowetting display devices comprising such fluids.Type: ApplicationFiled: February 12, 2013Publication date: January 15, 2015Applicant: Merck Patent GmbHInventors: Louise Diane Farrand, Nathan Smith, Roshan Kumar, Anthony Lawrence
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Patent number: 8835411Abstract: The disclosure generally relates to the novel compounds of formula I, including their salts, which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical compositions and methods for treating those infected with HIV.Type: GrantFiled: December 6, 2011Date of Patent: September 16, 2014Assignee: Bristol-Myers Squibb CompanyInventors: Yasutsuga Ueda, Timothy P. Connolly, Barry L. Johnson, Chen Li, B. Narasimhulu Naidu, Manoj Patel, Kevin Peese, Margaret E. Sorenson, Michael A. Walker, Michael S. Bowsher, Rongti Li
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Publication number: 20140221316Abstract: This disclosure relates to novel compounds containing an H2S releasing moiety and a nitric oxide (NO) releasing moiety covalently linked with a core (e.g., a salicylic acid moiety) and the use of such compounds in treating inflammatory diseases, including cancers. Therapeutic potency of these compounds is significantly higher than NSAIDs containing a H2S-releasing moiety alone (HS-NSAIDs) and NSAID containing a NO-releasing moiety alone (NO-NSAIDs). The compounds, in addition, exhibit reduced side effect, e.g., reduced stomach ulcers, upon administration.Type: ApplicationFiled: August 15, 2012Publication date: August 7, 2014Applicant: RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORKInventors: Khosrow Kashfi, Ravinder Kodela
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Publication number: 20130210773Abstract: In one aspect, the invention relates to indole compounds, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the muscarinic acetylcholine receptor M1 (mAChR M1); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.Type: ApplicationFiled: June 21, 2011Publication date: August 15, 2013Inventor: Craig W. Lindsley
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Patent number: 8389696Abstract: Polymerizable diazonium salts having redox properties and absorption in the visible range, a process for preparing them and uses thereof are disclosed. The salts have the general formula: [XX+LnDdEm(N2+)p][(B?)p+x] in which: X is chosen from transition metals, preferably X is chosen from ruthenium (Ru), osmium (Os), iron (Fe), cobalt (Co) and iridium (Ir), x is an integer ranging from 1 to 5 inclusive, L is a ligand chosen from pyridine, bipyridine, terpyridine, phenanthroline and phenylpyridine groups, and mixtures thereof, n is an integer ranging from 1 to 5 inclusive, D is a saturated or unsaturated, C1-C5 alkyl spacer compound, d=0 or 1, E is an aromatic or polyaromatic spacer compound that can contain one or more heteroatoms, m is an integer ranging from 0 to 5 inclusive, p is an integer, and B is a counterion.Type: GrantFiled: March 30, 2010Date of Patent: March 5, 2013Assignee: Commissariat a l'Energie AtomiqueInventors: Gérard Bidan, Bruno Jousselme, Rémi De Bettignies
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Publication number: 20130039860Abstract: Compounds and methods are disclosed that are useful for noninvasive imaging in the near-infrared spectral range. The cyanine compounds of Formula I are presented: wherein Q is a portion of a polymethine bridge: Also included are bioconjugates of the compounds of Formula I, methods of labeling biomolecules with the compounds, and methods of imaging.Type: ApplicationFiled: August 31, 2012Publication date: February 14, 2013Applicant: LI-COR, INC.Inventor: Lael Cheung
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Publication number: 20120309698Abstract: The disclosure generally relates to the novel compounds of formula I, including their salts, which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical compositions and methods for treating those infected with HIV.Type: ApplicationFiled: December 6, 2011Publication date: December 6, 2012Inventors: Yasutsugu Ueda, Timothy P. Connolly, Barry L. Johnson, Chen Li, B. Narasimhulu Naidu, Manoj Patel, Kevin Peese, Margaret E. Sorenson, Michael A. Walker, Michael S. Bowsher, Rongti Li
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Patent number: 8309695Abstract: The present invention relates to a labeling reagent of formula: in which: R1 represents at least one detectable label, L and A are each a linker arm, n is an integer equal to 1, and u is an integer between 0 and 2. The present invention also describes a method of synthesizing said markers and also applications for the labeling of biological molecules, more particularly nucleic acids, with a labeling reagent bearing diazo and nitro functions. The invention is particularly suitable for use in the diagnostics field.Type: GrantFiled: June 9, 2008Date of Patent: November 13, 2012Assignees: Biomerieux, CNRS, Universite de StrasbourgInventors: Alain Laurent, Ali Laayoun, Mitsuharu Kotera
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Patent number: 8232375Abstract: Disclosed is an azo compound represented by the formula (1) or (2) or a salt thereof. The azo compound or the salt thereof has an excellent light-polarizing property, and is extremely useful as a dichroic dye for use in a polarizing plate that shows less color leakage in a visible light range or a polarizing plate for a liquid crystal projector comprising the aforementioned polarizing plate. (1) (2) wherein R1 represents a hydrogen atom, a lower alkyl group, a lower alkoxy group, a hydroxyl group, a sulfonate group or a carboxyl group; R2 to R5 independently represent a hydrogen atom, a lower alkyl group, a lower alkoxy group or an acetylamino group; X represents a benzoylamino group which may have a substituent, a phenylamino group which may have a substituent, a phenylazo group which may have a substituent, or a naphthotriazole group which may have a substituent; m represents a numeral number of 1 or 2; and n represents a numeral number of 0 or 1.Type: GrantFiled: October 30, 2008Date of Patent: July 31, 2012Assignees: Nippon Kayaku Kabushiki Kaisha, Polatechno Co., Ltd.Inventors: Takahiro Higeta, Hiroaki Ohno, Yuichi Sadamitsu
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Publication number: 20120178723Abstract: This invention provides compounds of formula IA-a or IB-a and subsets thereof: wherein Z, HY, R1, R2, G1, W, n, and A and subsets thereof are as described in the specification. The compounds are inhibitors of PI3K and are thus useful for treating proliferative, inflammatory, or cardiovascular disorders.Type: ApplicationFiled: August 11, 2011Publication date: July 12, 2012Applicant: Millennium Pharmaceuticals, Inc.Inventors: Masaaki Hirose, Zhigen Hu, Yongbo Hu, Hong Myung Lee, Zhan Shi, Stepan Vyskocil, Tianlin Xu
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Patent number: 8053567Abstract: The use of at least one diazonium salt bearing an initiator function, for forming an undercoat obtained by grafting a graft derived from the diazonium salt and bearing an initiator function at the surface of a conductive or semiconductive material on the undercoat, and for forming on the undercoat a polymeric layer obtained by polymerization, in particular free radical polymerization, in situ of at least one monomer, initiated from the initiator function.Type: GrantFiled: June 2, 2005Date of Patent: November 8, 2011Assignees: Universite Paris 7—Denis Diderot, AlchimedicsInventors: Mohamed Mehdi Chehimi, Jean Pinson, Bernadette Charleux, Christophe Bureau, Christopher Tronche, Tarik Matrab, Christian Perruchot, Eva Cabet-Deliry, Maud Save
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Publication number: 20110171678Abstract: Chemically reactive carbocyanine dyes incorporating an indolium ring moiety that is substituted at the 3-position by a reactive group or by a conjugated substance, and their uses, are described. Conjugation through this position results in spectral properties that are uniformly superior to those of conjugates of spectrally similar dyes wherein attachment is at a different position. The invention includes derivative compounds having one or more benzo nitrogens.Type: ApplicationFiled: October 18, 2010Publication date: July 14, 2011Applicant: LIFE TECHNOLOGIES CORPORATIONInventors: Wai-Yee Leung, Ching-Ying Cheung, Stephen Yue
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Publication number: 20110071282Abstract: The invention relates to a process for preparing naphthalen-2-yl-pyrazol-3-one intermediates, tautomers, and salts thereof, to novel intermediates, and to the use of the intermediates in the preparation of sigma receptor inhibitors.Type: ApplicationFiled: April 24, 2009Publication date: March 24, 2011Applicant: LABORATORIOS DEL DR. ESTEVE, S.A.Inventors: Antoni Torrens Jover, Jordi Corbera Arjona, Maria Rosa Cuberes-Altisent
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Publication number: 20110011307Abstract: The present invention relates to a method of preparing a modified colored pigment comprising a pigment having attached at least one organic group. The method comprises the step of combining, in any order, a) a solution of an organic colorant in a solvent, b) at least one aromatic amine comprising the organic group, c) at least one diazotizing agent, d) an aqueous medium, e) optionally at least one acid, and f), optionally at least one second solvent, to form the modified colored pigment.Type: ApplicationFiled: July 21, 2010Publication date: January 20, 2011Inventors: Alexander I. Shakhnovich, Yuan Yu, Friedrich K. von Gottberg
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Patent number: 7812139Abstract: Polymerizable diazonium salts having redox properties and absorption in the visible range, a process for preparing them and uses thereof are disclosed. The salts have the general formula: [XX+LnDdEm(N2+)p][(B?)p+x] in which: X is chosen from transition metals, preferably X is chosen from ruthenium (Ru), osmium (Os), iron (Fe), cobalt (Co) and iridium (Ir), x is an integer ranging from 1 to 5 inclusive, L is a ligand chosen from pyridine, bipyridine, terpyridine, phenanthroline and phenylpyridine groups, and mixtures thereof, n is an integer ranging from 1 to 5 inclusive, D is a saturated or unsaturated, C1-C5 alkyl spacer compound, d=0 or 1, E is an aromatic or polyaromatic spacer compound that can contain one or more heteroatoms, m is an integer ranging from 0 to 5 inclusive, p is an integer, and B is a counterion.Type: GrantFiled: July 24, 2007Date of Patent: October 12, 2010Assignee: Commissariat A l'Energie AtomiqueInventors: Gérard Bidan, Bruno Jousselme, Rémi De Bettignies
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Publication number: 20100227834Abstract: The invention relates to special nucleosides, for example, a nucleoside of the formula I, wherein R1-R5 are as described herein, and also to drugs which contain these nucleosides. Furthermore, the invention relates to the use of such nucleosides in a method for suppressing or reducing the formation of resistance in the case of cytostatic treatment of a cancer patient.Type: ApplicationFiled: August 13, 2007Publication date: September 9, 2010Applicant: RESprotech GmbHInventors: Rudolf Fahrig, Dieter Lohmann, Andreas Rolfs, Henrik Dieks, Janek Teubner, Jörg-Christian Heinrich
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Publication number: 20100226008Abstract: Disclosed is an azo compound represented by the formula (1) or (2) or a salt thereof. The azo compound or the salt thereof has an excellent light-polarizing property, and is extremely useful as a dichroic dye for use in a polarizing plate that shows less color leakage in a visible light range or a polarizing plate for a liquid crystal projector comprising the aforementioned polarizing plate. (1) (2) wherein R1 represents a hydrogen atom, a lower alkyl group, a lower alkoxy group, a hydroxyl group, a sulfonate group or a carboxyl group; R2 to R5 independently represent a hydrogen atom, a lower alkyl group, a lower alkoxy group or an acetylamino group; X represents a benzoylamino group which may have a substituent, a phenylamino group which may have a substituent, a phenylazo group which may have a substituent, or a naphthotriazole group which may have a substituent; m represents a numeral number of 1 or 2; and n represents a numeral number of 0 or 1.Type: ApplicationFiled: October 30, 2008Publication date: September 9, 2010Applicants: NIPPON KAYAKU KABUSHIKI KAISHA, POLATECHNO CO., LTD.Inventors: Takahiro Higeta, Hiroaki Ohno, Yuichi Sadamitsu
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Publication number: 20100184932Abstract: Polymerizable diazonium salts having redox properties and absorption in the visible range, a process for preparing them and uses thereof are disclosed. The salts have the general formula: [XX+LnDdEm(N2+)p][(B?)p+x] in which: X is chosen from transition metals, preferably X is chosen from ruthenium (Ru), osmium (Os), iron (Fe), cobalt (Co) and iridium (Ir), x is an integer ranging from 1 to 5 inclusive, L is a ligand chosen from pyridine, bipyridine, terpyridine, phenanthroline and phenylpyridine groups, and mixtures thereof, n is an integer ranging from 1 to 5 inclusive, D is a saturated or unsaturated, C1-C5 alkyl spacer compound, d=0 or 1, E is an aromatic or polyaromatic spacer compound that can contain one or more heteroatoms, m is an integer ranging from 0 to 5 inclusive, p is an integer, and B is a counterion.Type: ApplicationFiled: March 30, 2010Publication date: July 22, 2010Inventors: Gerard Bidan, Bruno Jousselme, Rémi De Bettignies
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Publication number: 20100125132Abstract: A method for making diazo-compounds, diazonium salts thereof and other protected forms of these compounds. Diaz-compounds are prepared by reaction of a tertiary phosphine reagent carrying a reactive carbonyl group with an azide. The reaction can also generate an acyl triazene which can be converted thermally or by addition of base to form the diazo-compound or the acyl triazene can be isolated. The method is particularly useful for conversion of azides carrying one or more electron withdrawing groups to diazo-compounds. The method can be carried out in aqueous medium under mild conditions and is particularly useful for conversion of azido sugars to diazo-compound and diazonium salts thereof under physiological conditions. Tertiary phosphine reagents, particularly those that are water-soluble, and precursors for preparation of the reagents are provided.Type: ApplicationFiled: November 17, 2009Publication date: May 20, 2010Inventors: Ronald Thaddeus Raines, Eddie Leonard Myers
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Publication number: 20100076181Abstract: The invention provides a novel method of labeling oligonucleotides, with reporter moieties, including but not limited to, quenchers, fluorophores, biotin, digoxigenin, peptides and proteins. In addition, this invention provides a method of detecting hybridization of oligonucleotides. This invention also provides novel azo quenchers having the general formula shown below. The invention further provides compositions comprising labeled oligonucleotides and solid supports. The invention also provides kits comprising at least one composition of the present invention.Type: ApplicationFiled: November 23, 2009Publication date: March 25, 2010Applicant: INTEGRATED DNA TECHNOLOGIES, INC.Inventors: Andrei Laikhter, Joseph A. Walder, Mark Behlke, Mikhail Podyminogin, Yawfui Yong
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Publication number: 20100068783Abstract: A process for producing a substrate having an adhesive surface, which process comprises: (a) contacting the substrate with a carbene precursor, which carbene precursor is a compound of the following formula (1): whose substituent groups are SP defined herein, provided that when R is aryl or heteroaryl, said aryl or heteroaryl may be substituted by one, two, three, four or five groups, which groups are independently selected from various groups including -LB-WB; and (b) either: (i) when WA or WB comprises an adhesive functional group, generating a carbene reactive intermediate from the carbene precursor so that it reacts with the substrate to functionalise the surface, thereby yielding said substrate having an adhesive surface; or (ii) when WA or WB comprises a group which is a precursor of an adhesive functional group, generating a carbene reactive intermediate from the carbene precursor so that it reacts with the substrate to functionalise the surface, and (c) converting said group which is a precursor intoType: ApplicationFiled: August 22, 2007Publication date: March 18, 2010Applicant: ISIS INNOVATION LIMITEDInventors: Mark Moloney, Jon-Paul Griffiths
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Publication number: 20080289123Abstract: Reactive dyes of formula (I) are suitable for dyeing cellulosic or amide-group-containing fibre materials.Type: ApplicationFiled: September 19, 2005Publication date: November 27, 2008Applicant: HUNTSMAN INTERNATIONAL LLCInventors: Georg Roentgen, Athanassios Tzikas
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Publication number: 20080236666Abstract: Polymerizable diazonium salts having redox properties and absorption in the visible range, a process for preparing them and uses thereof are disclosed. The salts have the general formula: [XX+LnDdEm(N2+)p][(B?)p+x] in which: X is chosen from transition metals, preferably X is chosen from ruthenium (Ru), osmium (Os), iron (Fe), cobalt (Co) and iridium (Ir), x is an integer ranging from 1 to 5 inclusive, L is a ligand chosen from pyridine, bipyridine, terpyridine, phenanthroline and phenylpyridine groups, and mixtures thereof, n is an integer ranging from 1 to 5 inclusive, D is a saturated or unsaturated, C1-C5 alkyl spacer compound, d=0 or 1, E is an aromatic or polyaromatic spacer compound that can contain one or more heteroatoms, m is an integer ranging from 0 to 5 inclusive, p is an integer, and B is a counterion.Type: ApplicationFiled: July 24, 2007Publication date: October 2, 2008Inventors: Gerard Bidan, Bruno Jousselme, Remi De Bettignies
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Publication number: 20080167453Abstract: Cationic naphthyldiazo dyes of general formula (I) and colorants for keratin fibers containing these dyes.Type: ApplicationFiled: December 13, 2004Publication date: July 10, 2008Applicant: WELLA AGInventors: Otto Goettel, Andre Hayoz, Hans-Juergen Braun
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Publication number: 20080022467Abstract: Disazo dyes of general formula (V) wherein X, R1, M and n are as defined in the specification, are excellent yellow dyes for dying and printing of cellulose containing materials and textile materials, and, especially, for the preparation of inks for ink jet printing.Type: ApplicationFiled: July 27, 2007Publication date: January 31, 2008Inventors: Kurt Baettig, Gerald Jan
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Patent number: 7118844Abstract: A diazonium salt represented by the following general formula (1) and a thermal recording material using the diazonium salt: General Formula (1) wherein R1 and R2 each independently represents an alkyl group, an aryl group, an acyl group, an alkoxycarbonyl group or a carbamoyl group, and R1 and R2 may be linked each other to form a ring; and R3 to R6 each independently represents a hydrogen atom, a hydroxyl group, a halogen atom, an alkyl group, an aryl group, an alkoxy group, an aryloxy group, an alkylthio group, an arylthio group, an alkylsulfonyl group, an arylsulfonyl group or a diazonio group, and at least one of R3, R4, R5 and R6 represents the diazonio group.Type: GrantFiled: September 3, 2003Date of Patent: October 10, 2006Assignee: Fuji Photo Film Co., Ltd.Inventors: Akinori Fujita, Kimiatsu Nomura, Yoshihiro Jimbo, Hisato Nagase, Toshihide Aoshima, Yasuhiro Mitamura, Tatsuo Kawabuchi
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Patent number: 7064210Abstract: A light resistant colorant is obtained by coupling a dye or a pigment with a light resistant material. A light resistant colorant-containing composition has no additional light stabilizer. Therefore, side effects caused by the addition of a light stabilizer, such as precipitate generation, may be prevented. Furthermore, substrates to which the composition is applied preserve excellent light resistance for a long term.Type: GrantFiled: September 29, 2003Date of Patent: June 20, 2006Assignee: Samsung Electronics Co., Ltd.Inventors: Yeon-kyoung Jung, Seung-min Ryu
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Patent number: 7060806Abstract: The cationic dyes of formula (1) specified in claim 1 are suitable especially for colouring keratin-containing fibres, more especially for colouring hair.Type: GrantFiled: December 8, 2004Date of Patent: June 13, 2006Assignee: Ciba Specialty Chemicals CorporationInventor: Peter Möckli
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Patent number: 7022823Abstract: The present invention relates to a diazonium salt represented by the following general formula (1) and a synthesizing method thereof, as well as a recording material using the diazonium salt. In general formula (1), R1 represents a hydrogen atom, an alkyl group or an aryl group. R2 represents an alkyl group or an aryl group. Each of R3, R4, R5 and R6 independently represents a hydrogen atom or a monovalent substituent. Here, at least one of R3, R4, R5 and R6 represents —N2+X?. X? represents an anion.Type: GrantFiled: August 8, 2003Date of Patent: April 4, 2006Assignee: Fuji Photo Film Co., Ltd.Inventors: Kimiatsu Nomura, Hisato Nagase, Yasuhiro Mitamura
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Patent number: 6972334Abstract: A novel bathophenanthroline compound of the general formula [I] or [II] is provided wherein R1 and R2 may be the same or different and independently represent a linear, branched or cyclic, saturated or unsaturated hydrocarbon group, or a substituted or unsubstituted, saturated or unsaturated hydrocarbon group provided that at least one of R1 and R2 has at least two carbon atoms, and wherein Ar1 and Ar2 may be the same or different and independently represent a substituted or unsubstituted aryl group. A process for preparing the compound is also provided wherein bathophenanthroline and an organolithium compound are subjected to nucleophilic substitution reaction to obtain the compound of the above formula [I] or [II].Type: GrantFiled: November 2, 2000Date of Patent: December 6, 2005Assignee: Sony CorporationInventors: Tetsuo Shibanuma, Yasunori Kijima, Nobutoshi Asai, Shinichiro Tamura
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Patent number: 6875750Abstract: Aziridine derivatives of formula (I) are disclosed which can be used as cofactor for S-adenosyl-L-methionine-dependent methyltransferases.Type: GrantFiled: July 28, 1999Date of Patent: April 5, 2005Assignee: Max-Planck-Gesellschaft zur Foerderung der Wissenschaften E.V.Inventors: Marc Pignot, Elmar Weinhold
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Publication number: 20040127689Abstract: Activated haptens useful for generating immunogens to HIV protease inhibitors, immunogens useful for producing antibodies to HIV protease inhibitors, and antibodies and labeled conjugates useful in immunoassays for HIV protease inhibitors. The novel haptens feature an activated functionality at the central, non-terminal hydroxyl group common to all HIV protease inhibitors, e.g., saquinavir, nelfinavir, indinavir, amprenavir, ritonavir, lopinavir, and atazanavir.Type: ApplicationFiled: September 24, 2003Publication date: July 1, 2004Inventors: Gerald F. Sigler, Raymond A. Hui, Ina Deras, Richard Terry Root, Mitali Ghoshal, Erasmus Huber, Herbert W. Von Der Eltz, Sigrun Metz, Peter Kern
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Patent number: 6740741Abstract: Novel diazo derivatives useful for the deacidification of paper material and the process for their preparation comprising three steps starting from an amine and ethyl chlorocarbonate, are described.Type: GrantFiled: July 3, 2002Date of Patent: May 25, 2004Assignees: Consiglio Nazionale delle Ricerche, Universita'degli Studi di UdineInventors: Antonio Zappala', Andrea Gorassini, Angelo Guimanini, Giancarlo Verardo
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Patent number: 6713524Abstract: The invention relates to novel reactive polymers of formula wherein the variables are as defined in the claims. The polymers of the invention are useful for the modification of material surfaces and are particularly suitable for providing biomedical articles such as contact lenses with a hydrophilic coating.Type: GrantFiled: March 9, 2001Date of Patent: March 30, 2004Assignee: Novartis AGInventors: Jörg Leukel, Peter Chabrecek, Dieter Lohmann
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Publication number: 20040039180Abstract: The present invention relates to a diazonium salt represented by the following general formula (1) and a synthesizing method thereof, as well as a recording material using the diazonium salt.Type: ApplicationFiled: August 8, 2003Publication date: February 26, 2004Applicant: FUJI PHOTO FILM CO., LTD.Inventors: Kimiatsu Nomura, Hisato Nagase, Yasuhiro Mitamura
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Publication number: 20030191321Abstract: The present invention relates to intermediate thiazole compounds and a process for preparing 2-chloro-5-chloromethylthiazole which is a known compound useful for the preparation of insecticides.Type: ApplicationFiled: May 7, 2003Publication date: October 9, 2003Inventor: Kevin Coppola
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Publication number: 20030119754Abstract: The present invention relates to novel benzimidazole compounds that have useful antiviral activity. More specifically, the invention encompasses benzimidazole compounds that inhibit membrane fusion associated events such as viral transmission, reduce viral load or otherwise treat viral infections. The invention also encompasses the use of benzimidazole compounds as inhibitors of membrane fusion associated events, such as viral transmission. In another embodiment, the invention encompasses processes for making benzimidazole compounds, methods of using the benzimidazole compounds and compositions comprising the benzimidazole compounds. Finally, the invention provides methods for treating, preventing or ameliorating symptoms associated with respiratory infection, particularly that caused by Respiratory Syncytial Virus utilizing the novel benzimidazole compounds of the invention.Type: ApplicationFiled: May 9, 2002Publication date: June 26, 2003Inventors: John William Lackey, Daniel S. Kinder, Nicolai A. Tvermoes
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Publication number: 20030100766Abstract: The present invention relates to 3-substituted and 2,3-disubstituted pyridine compounds which are useful as intermediates in the synthesis of pyridylsulfonylurea herbicides. The invention also relates to arylation of alcohols using a pyridinediazonium salt. More particularly the arylation process of the instant invention relates to the synthesis of 2,3-disubstituted pyridine compounds via anhydrous diazotization of 3-amninopyridines to form a diazonium salt intermediate that is then reacted with the appropriate alcohol to produce the desired product. The invention additionally relates to pyridine-3-diazonium salt intermediates.Type: ApplicationFiled: December 16, 2002Publication date: May 29, 2003Inventor: Dean Kent Hoglen
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Publication number: 20030065153Abstract: Novel diazo derivatives useful for the deacidification of paper material and the process for their preparation comprising three steps starting from an amine and ethyl chlorocarbonate, are described.Type: ApplicationFiled: July 3, 2002Publication date: April 3, 2003Inventors: Antonio Zappala, Andrea Gorassini, Angelo Guimanini, Giancarlo Verardo
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Publication number: 20030055229Abstract: The present invention relates to intermediate thiazole compounds and a process for preparing 2-chloro-5-chloromethylthiazole which is a known compound useful for the preparation of insecticides.Type: ApplicationFiled: September 16, 2002Publication date: March 20, 2003Inventor: Kevin Coppola
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Patent number: 6531581Abstract: Compounds are described comprising purines substituted at the C-8 position and pyrimidines substituted at the C-4 position with a linker and quencher. These compounds, when incorporated into hairpin oligonucleotides quench the fluorescence of fluorophores linked to the 5′-terminus of the oligonucleotide. These nucleotide-quencher compounds are also easily incorporated into oligonucleotides using conventional or automated oligonucleotide synthetic techniques.Type: GrantFiled: October 26, 2000Date of Patent: March 11, 2003Assignee: Serologicals, Inc.Inventors: Glenn Nardone, Irena Nazarenko, Jila Boal
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Patent number: 6265553Abstract: The present invention relates to intermediate thiazole compounds and a process for preparing 2-chloro-5-chloromethylthiazole which is a known compound useful for the preparation of insecticides.Type: GrantFiled: August 10, 1999Date of Patent: July 24, 2001Assignee: Syngenta Crop Protection, Inc.Inventor: Kevin Coppola
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Publication number: 20010006805Abstract: The present invention relates to 3-substituted and 2,3-disubstituted pyridine compounds which are useful as intermediates in the synthesis of pyridylsulfonylurea herbicides. The invention also relates to arylation of alcohols using a pyridinediazonium salt. More particularly the arylation process of the instant invention relates to the synthesis of 2,3-disubstituted pyridine compounds via anhydrous diazotization of 3-aminopyridines to form a diazonium salt intermediate that is then reacted with the appropriate alcohol to produce the desired product. The invention additionally relates to pyridine-3-diazonium salt intermediates.Type: ApplicationFiled: January 22, 2001Publication date: July 5, 2001Inventor: Dean Kent Hoglen
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Patent number: 6245953Abstract: In a method for recovering a fluorine-containing solvent from the mixture comprising the fluorine-containing solvent and dyes, (i) a method for recovering a fluorine-containing solvent by distillation; and (ii) a method for recovering a fluorine-containing solvent comprising the steps of adding to the mixture the second solvent which uniformly mixes with the fluorine-containing solvent but does not dissolve the dyes; separating a precipitate from the resulting mixture; and separating the second solvent.Type: GrantFiled: November 22, 1999Date of Patent: June 12, 2001Assignee: Daikin Industries, Ltd.Inventors: Fumihiko Yamaguchi, Toshiyuki Katsube
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Patent number: 6143460Abstract: A novel diazodisulfone compound capable of generating acid having high sensitivity to far ultraviolet rays typified by a KrF excimer laser and the like and capable of providing a resist with superior resolution and patterns when used as a photoacid generator for a chemically amplified resist, and a radiation-sensitive resin composition comprising the diazodisulfone compound. The diazodisulfone compound is represented by the following formulas (1) and (2). ##STR1## The radiation-sensitive resin composition comprises the diazodisulfone compound and resin represented by 4-hydroxystyrene/4-(1'-ethoxyethoxy)styrene copolymer.Type: GrantFiled: May 19, 1999Date of Patent: November 7, 2000Assignee: JSR CorporationInventors: Eiichi Kobayashi, Ken-ichi Yokoyama, Yong Wang, Shin-ichiro Iwanaga
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Patent number: 6140368Abstract: The present invention relates to a novel class of compounds that are potent inhibitors of HIV reverse transcriptase and HIV integrase. In addition to being multienzyme inhibitors, the inventive compounds of the present invention are remarkable in at least two other respects. First, they do not appear to be toxic to cells at typical therapeutic concentrations. Second, they appear to be equally effective against mutant strains of HIV reverse transcriptase commonly found in patients who have developed resistance to current reverse transcriptase inhibitors. Because the inventive compounds show promise in combatting viral resistance and are potent inhibitors of both HIV reverse transcriptase and integrase, they are ideal candidates for use in combination with existing therapies or alone in treating AIDS or HIV infection.Type: GrantFiled: May 4, 1998Date of Patent: October 31, 2000Assignees: The Regents of the University of California, Rutgers, The University of New JerseyInventors: George L. Kenyon, Margaret Stauber, Karl Maurer, Dolan Eargle, Angelika Muscate, Andrew Leavitt, Diana C. Roe, Todd J. A. Ewing, Allan G. Skillman, Jr., Edward Arnold, Irwin D. Kuntz, Malin Young
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Patent number: 6127529Abstract: Bifuncitonal chelating pyridine compound and its use for conferring chelating properties on organic compounds. The pyridine compound has the structure ##STR1## where (i) n is an integer 1 or 2,(ii) R.sub.1, R.sub.2 and R.sub.3 represent groups that have no electrons capable of significantly delocalizing or resonating with the pyridine ring, such as hydrogen, alkyl or aralkyl having an aliphatic carbon atom next to the pyridine ring; at least two of R.sub.1, R.sub.2 and R.sub.Type: GrantFiled: September 13, 1991Date of Patent: October 3, 2000Assignee: Wallac OyInventors: Marek Kwiatkowski, Christian Sund, Jyrki Ylikoski, Veli-Matti Mukkala, Ilkka Hemmila
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Patent number: 6107491Abstract: Diketopyrrolopyrroles of formula I ##STR1## wherein R.sub.1 is a radical of formula II--Y--X--Z--Q (II),whereinY is --CR.sub.3 R.sub.4, --SO.sub.2 --, --CO--, --Si(Hal).sub.2 --, --POHal--, wherein R.sub.3 and R.sub.4 are each independently of the other hydrogen or C.sub.1 -C.sub.4 alkyl, and Hal is halogen,X is an unsubstituted or substituted carbocylic or heterocyclic arylene group,Z is a single bond, uninterrupted linear or branched C.sub.1 -C.sub.30 alkylene, or linear or branched C.sub.2 -C.sub.30 alkylene which is interrupted once or more than once by a hetero atom, --CH.dbd.CH--,--C.tbd.C--, --N.dbd.CH--, --CH.dbd.N-- or --NH--, or is C.sub.5 -C.sub.12 cycloalkylene,Q is a polyreactive functional group, andR.sub.2 is C.sub.1 -C.sub.6 alkyl, ##STR2## or R.sub.1, and R.sub.7 is hydrogen or C.sub.1 -C.sub.Type: GrantFiled: January 26, 1999Date of Patent: August 22, 2000Assignee: Ciba Specialty Chemicals CorporationInventor: Sameer Eldin