Oxidized Starch Or Derivative Patents (Class 536/105)
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Patent number: 9068022Abstract: A process for modifying starch is described. The process can be used as an alternative to conventional starch modification processes, such as substitution and crosslinking. The process and resulting product can reduce, substantially reduce, substantially eliminate or eliminate the sodium level typically associated with conventionally modified starch products.Type: GrantFiled: April 15, 2013Date of Patent: June 30, 2015Assignee: General Mills, Inc.Inventors: Ling-Hua Han, Ya-Jane Wang
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Publication number: 20150148531Abstract: The invention relates to a method for the manufacture of carbonyl derivatives of polysaccharides and to the oxidization of polysaccharides in the presence of nitrogen dioxide to yield carbonyl derivatives of polysaccharides. The products including carbonyl derivatives of polysaccharides, obtained by the method are also described.Type: ApplicationFiled: May 15, 2013Publication date: May 28, 2015Applicant: TEKNOLOGIAN TUTKIMUSKESKUS VTTInventors: Hannu Mikkonen (deceased), Sauli Vuoti
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Patent number: 8580951Abstract: Novel aldehyde-functionalized polysaccharide compositions are described that are more stable in aqueous solution than oxidized polysaccharides or other types of polysaccharides containing pendant aldehyde groups. The aldehyde-functionalized polysaccharides may be reacted with various amine-containing polymers to form hydrogel tissue adhesives and sealants that may be useful for medical applications such as wound closure, supplementing or replacing sutures or staples in internal surgical procedures such as intestinal anastomosis and vascular anastomosis, tissue repair, preventing leakage of fluids such as blood, bile, gastrointestinal fluid and cerebrospinal fluid, ophthalmic procedures, drug delivery, and preventing post-surgical adhesions.Type: GrantFiled: July 1, 2010Date of Patent: November 12, 2013Assignee: Actamax Surgical Materials, LLCInventors: Helen S. M. Lu, Steven W. Shuey
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Patent number: 8580950Abstract: Novel aldehyde-functionalized polysaccharide compositions containing pendant dialdehyde groups are described that are more stable in aqueous solution than oxidized polysaccharides. The aldehyde-functionalized polysaccharides may be reacted with various amine-containing polymers to form hydrogel tissue adhesives and sealants that may be useful for medical applications such as wound closure, supplementing or replacing sutures or staples in internal surgical procedures such as intestinal anastomosis and vascular anastomosis, tissue repair, preventing leakage of fluids such as blood, bile, gastrointestinal fluid and cerebrospinal fluid, ophthalmic procedures, drug delivery, and preventing post-surgical adhesions.Type: GrantFiled: December 21, 2010Date of Patent: November 12, 2013Assignee: Actamax Surgical Materials, LLCInventors: Helen S. M. Lu, Steven W. Shuey
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Patent number: 8552178Abstract: A biopolymer thinning process is provided comprising the steps of (a) mixing a biopolymer substrate with a thinning agent and an alkalizing agent; and (b) drying the mixture of step (a), wherein the thinning agent consists of one or more hypochlorites; and step (a) is carried out at a neutral to alkaline pH and does not involve any artificial heating.Type: GrantFiled: December 21, 2006Date of Patent: October 8, 2013Assignee: Cargill, IncorporatedInventors: Marc Charles Florent Berckmans, Dogan Sahin Sivasligil
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Patent number: 8466277Abstract: The invention relates to a method for coupling low-molecular weight substances to a starch-derived modified polysaccharide. The binding interaction between the modified polysaccharide and the low-molecular weight substance is based on a covalent bond which is the result of a coupling reaction between the terminal aldehyde group or a functional group of the modified polysaccharide molecule resulting from the chemical reaction of this aldehyde group and a functional group of the low-molecular weight substance which reacts with this aldehyde group or with the resulting functional group of the polysaccharide molecule. The bond directly resulting from the coupling reaction can be optionally modified by a further reaction to the aforementioned covalent bond. The invention further relates to pharmaceutical compositions that comprise conjugates formed in this coupling process and to the use of said conjugates and compositions for the prophylaxis or therapy of the human or animal body.Type: GrantFiled: February 28, 2003Date of Patent: June 18, 2013Assignee: Fresenius Kabi Deutschland GmbHInventors: Michele Orlando, Jurgen Hemberger, Klaus Sommermeyer, Wolfram Eichner, Sven Frie, Katharina Lutterbeck, Cornelius Jungheinrich, Roland Scharpf
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Patent number: 8404834Abstract: The invention relates to a method for the preparation of a hydroxyalkyl starch derivative which comprises reacting hydroxyalkyl starch (HAS) via the optionally oxidized reducing end of the HAS with the amino group M of a crosslinking compound which, apart from the amino group, comprises a specifically protected carbonyl group, namely an acetal group or a ketal group.Type: GrantFiled: December 15, 2008Date of Patent: March 26, 2013Assignee: Fresenius Kabi Deutschland GmbHInventors: Frank Hacket, Thomas Hey, Franziska Hauschild, Helmut Knoller, Martin Schimmel, Klaus Sommermeyer
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Publication number: 20130056678Abstract: The present invention relates to pharmaceutical compositions containing carboxylated starch derivatives as well a their use as osmotics in particular for use in the treatment of chronic renal failure by dialysis.Type: ApplicationFiled: September 7, 2012Publication date: March 7, 2013Applicant: Corporation Fresenius Medical Care Deutschland GmbHInventors: Dominik Fenn, Thomas Schweitzer
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Patent number: 8252322Abstract: The present invention is directed to a dry composition which allows delivery of active agents with good bioavailability. These compositions are prepared by emulsifying the active agent using liposome technology known in the art and then encapsulating with a modified starch. The modified starch is prepared by enzymatic hydrolysis of starch after the preparation of a starch derivative containing a hydrophobic group or both a hydrophobic and a hydrophilic group. The resultant composition is a dry powder with excellent bioavailability. Further, the composition has good load levels and stability.Type: GrantFiled: June 3, 2003Date of Patent: August 28, 2012Assignee: Corn Products Development, Inc.Inventors: Paolo C. Trubiano, Afaf Karras
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Patent number: 8252921Abstract: The invention relates to a method for the controlled oxidation of oligo- and/or polysaccharides containing free —CH2OH primary hydroxyl groups, using an oxidizing agent. The invention is characterized in that the oxidation reaction is performed in a densified fluid which is inert in relation to the oxidizing agents employed. The invention is suitable for use, for example, in the food, paint, paper, textile, agricultural and pharmaceutical industries, in the medical, biomedical or paramedical fields, in the surgical field, in the cosmetic industry and as agents for the complexing or sequestering of metal ions, heavy metals and radioactive elements in the nuclear industry.Type: GrantFiled: July 29, 2005Date of Patent: August 28, 2012Assignees: Centre National de la Recherche Scientifique (CNRS), Institute National Polytechnique de ToulouseInventors: Michel Vignon, Suzelei Montanari, Daniel Samain, Jean-Stéphane Condoret
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Publication number: 20120172586Abstract: The present invention relates to a process for preparing a chemically modified polysaccharide, preferably starch, by using a microdevice. It further relates to the use of a microdevice for the chemical reactions of polysaccharides in heterogeneous mixtures. Examples of chemical modifications are acetylation, oxidation, hydroxypropylation and the like.Type: ApplicationFiled: August 19, 2010Publication date: July 5, 2012Applicant: CARGILL INCORPORATEDInventors: Marc Charles Florent Berckmans, Rita Maria Delrue, Bruno Frédéric Stengel
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Publication number: 20120070554Abstract: Batch process for the manufacture of oxidized starch by contacting an aqueous medium comprising already oxidized starch with native starch and with at least one oxidizing agent selected from a peroxide compound or from an alkali metal hypochlorite, and by reacting them at a temperature below the gelatinization temperature of the native starch and of the oxidized starch, the reaction being conducted in the presence of a homogeneous manganese-based complex coordination catalyst when the oxidizing agent is a peroxide compound. The resulting oxidized starch can be used as an additive for the paper industry or for the food industry.Type: ApplicationFiled: June 2, 2010Publication date: March 22, 2012Applicant: SOLVAY SAInventor: Pierre Dournel
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Publication number: 20120053338Abstract: Disclosed herein are methods for modifying carbohydrates using hydroxyl radicals. The hydroxyl radicals may be formed by the photolysis of peroxide in aqueous solution using UV light. Also disclosed are compositions and products comprising carbohydrates modified by the process.Type: ApplicationFiled: August 24, 2010Publication date: March 1, 2012Inventor: Roman SKURATOWICZ
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Patent number: 8076473Abstract: A starch thinning and etherification process is provided comprising the steps of (a) mixing a starch substrate with a thinning agent, an alkalizing agent and an etherification agent; (b) drying the mixture of step (a); and (c) allowing the dried mixture to react with the etherification agent, wherein: the thinning agent consists of one or more hypochlorites; step (a) is carried out at an alkaline pH and does not involve any artificial heating; and step (b) is carried out before the mixture of step (a) reaches the starch substrate's gelatinisation temperature.Type: GrantFiled: December 21, 2006Date of Patent: December 13, 2011Assignee: Cargill, IncorporatedInventors: Marc Charles Florent Berckmans, Dogan Sahin Sivasligil
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Patent number: 8049004Abstract: Processes for making ethersuccinylated hydroxyl polymers are provided.Type: GrantFiled: August 5, 2010Date of Patent: November 1, 2011Assignee: The Procter & Gamble CompanyInventor: Stephen Wayne Heinzman
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Publication number: 20110236935Abstract: A method of oxidising a saccharide, by contacting the saccharide with an alcohol dehydrogenase (ADH) enzyme selected from a quinone redox cofactor-dependent ADH, a nicotinamide adenine dinucleotide (NAD+) redox cofactor-dependent ADH, a nicotinamide adenine dinucleotide phosphate (NADP+) redox cofactor-dependent ADH, and any combination thereof is described. An oxidised saccharide obtainable by the method and products, in particular food products and paper products, containing the oxidised saccharide, are also described.Type: ApplicationFiled: October 29, 2010Publication date: September 29, 2011Inventors: Jørn Dalgaard Mikkelsen, Karsten Matthias Kragh, Rene Mikkelsen, Patrick Maria Franciscus Derkx, Shukun Yu, Harm Mulder, Igor Nikolaev
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Publication number: 20110146524Abstract: The present inventor has discovered a new combination composition using modified oxidized starches blended with shortening oil FL30™ and vegetables oil or combination of modified oxidized starches with polyethylene glycol attributed improvement in enhanced water soluble dye for encapsulation into impact ruptured projectile capsules. In a preferred embodiment of the enhanced composition, the aforesaid improvement over prior art of manufacturing native starches mixed with vegetables oil or polyethylene glycol is relates to significant chemical binding stability in the present of carbonyl and carboxylic groups, acetylation, cross-linked, physically modified, enzymatically modified, acid or alkaline treated and hydroxypropylation processes that can reduce retrogradation and syneresis, increased swelling power and solubility in free flowing attribution for greater splattering effect and completely washable solubility.Type: ApplicationFiled: December 17, 2009Publication date: June 23, 2011Inventor: Tornee Pang
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Patent number: 7932377Abstract: A molecular complex of a high molecular weight carrier substance and of a medicinal substance. The carrier substance has functional groups whereby the carrier substance and the medicinal substance are bound non-covalently. The medicinal substance is insoluble or slightly soluble in water and the carrier substance is readily soluble in water. The carrier substance can be starch or a starch derivative and can have only one functional group for non-covalent binding of the medicinal substance in each molecule.Type: GrantFiled: May 28, 2004Date of Patent: April 26, 2011Assignee: Supramol Parenteral Colloids GmbHInventor: Klaus Sommermeyer
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Patent number: 7897760Abstract: Nucleic acid molecules are described encoding a starch granule-bound protein as well as methods and recombinant DNA molecules for the production of transgenic plant cells and plants synthesizing a modified starch with modified viscosity properties and a modified phosphate content. Moreover, the plant cells and plants resulting from those methods as well as the starch obtainable therefrom are described.Type: GrantFiled: October 19, 2006Date of Patent: March 1, 2011Assignee: Bayer BioScience GmbHInventors: Jens Kossmann, Ruth Lorberth
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Publication number: 20100266743Abstract: The invention is directed to a method for agglomerating starch, to starch obtainable by said method, to a food product comprising said starch, and to the use of said starch. The method of the invention comprises the mixing of starch with an aqueous solution comprising a salt and drying the mixture.Type: ApplicationFiled: December 10, 2008Publication date: October 21, 2010Inventors: Zhenghong Chen, Pieter Lykle Buwalda
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Patent number: 7772391Abstract: Ethersuccinylated hydroxyl polymers, processes for making ethersuccinylated hydroxyl polymers, and uses of ethersuccinylated hydroxyl polymers are provided.Type: GrantFiled: April 26, 2006Date of Patent: August 10, 2010Assignee: The Procter & Gamble CompanyInventor: Stephen Wayne Heinzman
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Publication number: 20100197905Abstract: Modified polysaccharide polymers for use as anti-sealant and dispersant. The polymers are useful in compositions used in aqueous systems. The modified polysaccharides are also useful in detergent formulations, water treatment, dispersants and oilfield applications and as fiberglass binders. Such applications include a modified polysaccharide having up to about 70 mole % carboxyl groups per mole of polysaccharide ASU and up to about 20 mole % aldehyde groups per mole of polysaccharide ASU. The applications can also include a blend of modified polysaccharides and other synthetic polymers.Type: ApplicationFiled: April 14, 2010Publication date: August 5, 2010Inventors: Klin A. Rodrigues, John S. Thomaides, A. Levent Cimecioglu, Martin Crossman
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Publication number: 20100069280Abstract: Hybrid copolymers for use as anti-sealant and dispersant. The polymers are useful in compositions used in aqueous systems. The polymers include at least one synthetic monomeric constituent that is chain terminated by a naturally occurring hydroxyl containing moiety. A process for preparing these hybrid copolymers is also provided.Type: ApplicationFiled: November 24, 2009Publication date: March 18, 2010Applicant: Akzo Nobel N.V.Inventors: Klin A. RODRIGUES, Darin K. Griffith
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Patent number: 7608708Abstract: The present invention relates to monocotyledon plant cells and plants which are genetically modified, wherein the genetic modification consists of the introduction of an extraneous nucleic acid molecule which codes for a protein with the biological activity of an R1 protein. The present invention further relates to means and methods for the production thereof. Plant cells and plants of this type synthesise a modified starch, which is characterised in that it has an increased phosphate content and/or a modified phosphorylation pattern and/or an increased final viscosity in an RVA profile and/or a reduced peak temperature in DSC analysis and/or an increased gel strength in the texture analysis compared with starch from corresponding non-genetically modified monocotyledon plants. Therefore, the present invention also relates to the starch which is synthesised from the plant cells and plants according to the invention, and to methods of producing said starch.Type: GrantFiled: October 24, 2006Date of Patent: October 27, 2009Assignee: Bayer CropScience AGInventors: Gabi Schewe, Petra Knies, Simone Franceska Amati, Horst Lörz, Dirk Becker, Volker Landschütze, Jens Pilling
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Patent number: 7569556Abstract: The use of chemically modified dicarboxy polysaccharides for the topical treatment of the eyeball are described. The modified polysaccharides provide a carrier in solutions for the treatment of the eyeball to obtain a timed release.Type: GrantFiled: May 10, 2005Date of Patent: August 4, 2009Assignee: Board of Trustees of Michigan State UniversityInventors: Ramani Narayan, Laura M. Fisher
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Publication number: 20090054639Abstract: Process for the manufacture of oxidized starch by reacting an aqueous slurry of starch with a peroxide compound, the reaction being carried out in the presence of ozone or by irradiating the slurry with UV light, the amount of peroxide compound used being lower than 30 % by weight calculated on the basis of the weight of dry starch. The oxidized starch can be used as additive for the paper industry or for the food industry.Type: ApplicationFiled: February 22, 2007Publication date: February 26, 2009Applicant: SOLVAY (SOCIETE ANONYME)Inventors: Pierre Dournel, Jean-Pierre Ganhy
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Patent number: 7456265Abstract: Chemically modified dicarboxy polysaccharides are described. The modified polysaccharides are useful as a carrier for cosmetics, pharmaceuticals, veterinary products and the like. The modified polysaccharides can provide a timed release of active ingredients.Type: GrantFiled: May 10, 2005Date of Patent: November 25, 2008Assignee: Board of Trustees of Michigan State UniversityInventors: Ramani Narayan, Laura M. Fisher
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Publication number: 20080194805Abstract: The invention relates to a method for the controlled oxidation of oligo- and/or polysaccharides containing free —CH2OH primary hydroxyl groups, using an oxidising agent. The invention is characterised in that the oxidation reaction is performed in a densified fluid which is inert in relation to the oxidising agents employed. The invention is suitable for use, for example, in the food, paint, paper, textile, agricultural and pharmaceutical industries, in the medical, biomedical or paramedical fields, in the surgical field, in the cosmetic industry and as agents for the complexing or sequestering of metal ions, heavy metals and radioactive elements in the nuclear industry.Type: ApplicationFiled: July 29, 2005Publication date: August 14, 2008Inventors: Michel Vignon, Suzelei Montanari, Daniel Samain, Jean-Stephane Condoret
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Patent number: 7247722Abstract: Polysaccharide aldehydes are prepared using selective oxidation involving the use of nitroxyl radical mediated aqueous oxidation with a limited amount of oxidant and defined reaction conditions. These polysaccharide aldehyde derivatives having maximum effective aldehyde and minimal carboxylic acid levels making them especially useful as wet, temporary wet and dry strength additives for paper.Type: GrantFiled: April 23, 2003Date of Patent: July 24, 2007Assignee: National Starch and Chemical Investment Holding CorporationInventors: A. Levent Cimedoglu, John S. Thomaides
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Patent number: 7244839Abstract: The present invention is directed to a starch comprising a novel percentage of actual amylose. A grain comprising the starch is also embodied by the present invention. The present invention is also directed to a plant comprising the novel starch.Type: GrantFiled: March 26, 2003Date of Patent: July 17, 2007Assignee: E. I. du Pont de Nemours and CompanyInventors: Richard W. Pearlstein, Karen E. Broglie, Christopher F. Hines
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Patent number: 7217816Abstract: The present invention relates to monocotyledon plant cells and plants which are genetically modified, wherein the genetic modification consists of the introduction of an extraneous nucleic acid molecule which codes for a protein with the biological activity of an R1 protein. The present invention further relates to means and methods for the production thereof. Plant cells and plants of this type synthesise a modified starch, which is characterised in that it has an increased phosphate content and/or a modified phoshorylation pattern and/or an increased final viscosity in an RVA profile and/or a reduced peak temperature in DSC analysis and/or an increased gel strength in the texture analysis compared with starch from corresponding non-genetically modified monocotyledon plants. Therefore, the present invention also relates to the starch which is synthesised from the plant cells and plants according to the invention, and to methods of producing said starch.Type: GrantFiled: March 5, 2004Date of Patent: May 15, 2007Assignee: Aventis Cropscience GmbHInventors: Gabi Schewe, Petra Knies, Simone Franceska Amati, Horst Lörz, Dirk Becker, Volker Landschütze, Jens Pilling
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Patent number: 7176190Abstract: Nucleic acid molecules are described encoding a starch granule-bound protein as well as methods and recombinant DNA molecules for the production of transgenic plant cells and plants synthesizing a modified starch with modified viscosity properties and a modified phosphate content. Moreover, the plant cells and plants resulting from those methods as well as the starch obtainable therefrom are described.Type: GrantFiled: December 30, 2003Date of Patent: February 13, 2007Assignee: Bayer Bioscience GmbHInventors: Jens Kossmann, Ruth Lorbeth
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Patent number: 7157573Abstract: The invention relates to a process for preparing a hydrophobic starch, comprising etherification, esterification or amidation of a root or tuber starch comprising at least 95 wt. % of amylopectin, based on dry substance of the starch, or a derivative thereof, with a substituent comprising an alkyl chain having from 4–24 carbon atoms. The invention further relates to a hydrophobic starch obtainable by said process.Type: GrantFiled: August 17, 2005Date of Patent: January 2, 2007Assignee: Cooperatie Avebe U.A.Inventors: Pieter Lykle Buwalda, Ronald Peter W. Kesselmans, Augustinus Arnoldus M. Maas, Hylke Hotze Simonides
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Patent number: 7135557Abstract: A method of making a carboxylated carbohydrate is disclosed, cellulose being a preferred carbohydrate material. Carboxylated cellulose fibers can be produced whose fiber strength and degree of polymerization is not significantly sacrificed. The method involves the use of a catalytic amount of a hindered cyclic oxammonium compounds as a primary oxidant and chlorine dioxide as a secondary oxidant in an aqueous environment. The oxammonium compounds may be formed in situ from their corresponding amine, hydroxylamine, or nitroxyl compounds. The oxidized cellulose may be stabilized against D.P. loss and color reversion by further treatment with an oxidant such as sodium chlorite or a chlorine dioxide/hydrogen peroxide mixture. Alternatively it may be treated with a reducing agent such as sodium borohydride. In the case of cellulose the method results in a high percentage of carboxyl groups located at the fiber surface.Type: GrantFiled: September 3, 2004Date of Patent: November 14, 2006Assignee: Weyerhaeuser CompanyInventors: S. Ananda Weerawarna, Joseph Lincoln Komen, Richard A. Jewell
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Patent number: 7109325Abstract: A method of making a carboxylated carbohydrate is disclosed, cellulose being a preferred carbohydrate material. Carboxylated cellulose fibers can be produced whose fiber strength and degree of polymerization is not significantly sacrificed. The method involves the use of a catalytic amount of a hindered cyclic oxammonium compounds as a primary oxidant and chlorine dioxide as a secondary oxidant in an aqueous environment. The oxammonium compounds may be formed in situ from their corresponding amine, hydroxylamine, or nitroxyl compounds. The oxidized cellulose may be stabilized against D.P. loss and color reversion by further treatment with an oxidant such as sodium chlorite or a chlorine dioxide/hydrogen peroxide mixture. Alternatively it may be treated with a reducing agent such as sodium borohydride. In the case of cellulose the method results in a high percentage of carboxyl groups located at the fiber surface.Type: GrantFiled: August 30, 2004Date of Patent: September 19, 2006Assignee: Weyerhaeuser CompanyInventors: Joseph Lincoln Komen, S. Ananda Weerawarna, Richard A. Jewell
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Patent number: 7091335Abstract: Disclosed are derivatized malto-oligosaccharides and methods for the preparation thereof. In accordance with the disclosed invention, a malto-oligosaccharide is hydrogenated to thereby obtain a hydrogenated malto-oligosaccharide, and the resulting hydrogenated malto-oligosaccharide is derivatized, such as via oxidation, esterification, etherification, or enzymatic modification. The derivatization of such hydrogenated malto-oligosaccharides results in a surprisingly low level of a formation of by-products and products of degradation. In a particularly preferred embodiment of the invention, a mixture of malto-oligosaccharides is catalytically hydrogenated under reaction conditions suitable to substantially preserve the degree of polymerization (DP) profile of the mixture. The resulting malto-oligosaccharide mixture then is derivatized to form a derivatized malto-oligosaccharide mixture.Type: GrantFiled: December 9, 2003Date of Patent: August 15, 2006Assignee: Grain Processing CorporationInventors: Richard L. Antrim, Frank W. Barresi
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Patent number: 7091192Abstract: Linear cyclodextrin copolymers and linear oxidized cyclodextrin copolymers containing an unoxidized and/or an oxidized cyclodextrin moiety integrated into the polymer backbone are described. Methods of preparing such copolymers are also described. The linear cyclodextrin copolymer and linear oxidized cyclodextrin copolymer of the invention may be used as a delivery vehicle of various therapeutic agents.Type: GrantFiled: June 25, 1999Date of Patent: August 15, 2006Assignee: California Institute of TechnologyInventors: Mark E. Davis, Hector Gonzalez, Suzie Sue Jean Hwang
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Patent number: 7071327Abstract: A superabsorbent polysaccharide can be obtained by crosslinking a polysaccharide or derivative thereof with at least 1% by weight of a flexible spacer having a chain length of at least 9 chain atoms and having terminal activated coupling groups. The flexible spacer may comprise a polyalkyleneglycol with a molecular weight from about 400 to 10,000. The coupling groups may be provided by divinyl sulphone units.Type: GrantFiled: March 9, 2001Date of Patent: July 4, 2006Assignee: SCA Hygiene Products ABInventors: Guiseppe Mensitieri, Fabrizio Porro, Luigi Nicolais, Alessandro Sannino
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Patent number: 6936710Abstract: Primary hydroxyl groups in a substrate having both primary and secondary hydroxyl groups can be selectively oxidized to carbaldehyde and/or carboxyl groups by contacting the substrate with a cyclic nitroxyl compound in the presence of a peroxosulfate as a co-oxidant and by carrying out the reaction at a temperature below 30° C. and at a pH below 9. The process is halogen-free and metal-free and is especially suitable for oxidizing polysaccharides.Type: GrantFiled: December 13, 2001Date of Patent: August 30, 2005Assignee: SCA Hygiene Products Zeist B.V.Inventors: Petter Bragd, Arie Cornelis Besemer
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Patent number: 6919447Abstract: A method of making a carboxylated carbohydrate is disclosed, cellulose being a preferred carbohydrate material. Carboxylated cellulose fibers can be produced whose fiber strength and degree of polymerization is not significantly sacrificed. The method involves the use of a catalytic amount of a hindered cyclic oxammonium compounds as a primary oxidant and chlorine dioxide as a secondary oxidant in an aqueous environment. The oxammonium compounds may be formed in situ from their corresponding amine, hydroxylamine, or nitroxyl compounds. The oxidized cellulose may be stabilized against D.P. loss and color reversion by further treatment with an oxidant such as sodium chlorite or a chlorine dioxide/hydrogen peroxide mixture. Alternatively it may be treated with a reducing agent such as sodium borohydride. In the case of cellulose the method results in a high percentage of carboxyl groups located at the fiber surface.Type: GrantFiled: June 6, 2001Date of Patent: July 19, 2005Assignee: Weyerhaeuser CompanyInventors: Joseph Lincoln Komen, S. Ananda Weerawarna, Richard A. Jewell
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Patent number: 6884789Abstract: Linear cyclodextrin copolymers and linear oxidized cyclodextrin copolymers containing an unoxidized and/or an oxidized cyclodextrin moiety integrated into the polymer backbone are described. Methods of preparing such copolymers are also described. The linear cyclodextrin copolymer and linear oxidized cyclodextrin copolymer of the invention may be used as a delivery vehicle of various therapeutic agents.Type: GrantFiled: March 15, 2002Date of Patent: April 26, 2005Assignee: California Institute of TechnologyInventors: Mark E. Davis, Hector Gonzalez, Suzie (Sue Jean) Hwang
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Patent number: 6875861Abstract: A process for producing nitrosonium ions is described, in which a nitroxyl compound such as TEMPO is oxidized using an oxidizing agent in the presence of a complex of a transition metal such as Mn, Fe, Cu, and a complexing agent such as a polyamine. The process is useful for the oxidation of carbohydrates containing at least 1 cyclic monosaccharide chain group carrying a carbaldehyde group per 100 or per 25 monosaccharide units and per molecule.Type: GrantFiled: February 24, 2000Date of Patent: April 5, 2005Assignee: SCA Hygiene Products Zeist B.V.Inventors: Arie Cornelis Besemer, Jan Matthijs Jetten, Thomas Jaschinski, Ronald Tako Marinus Van Den Dool
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Patent number: 6872821Abstract: Polysaccharide aldehydes are prepared using selective oxidation involving the use of nitroxyl radical mediated aqueous oxidation with a limited amount of oxidant and defined reaction conditions. These polysaccharide aldehyde derivatives having maximum effective aldehyde and minimal carboxylic acid levels making them especially useful as wet, temporary wet and dry strength additives for paper.Type: GrantFiled: April 23, 2003Date of Patent: March 29, 2005Assignee: National Starch & Chemical Investment Holding CorporationInventors: A. Levent Cimecioglu, John S. Thomaides
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Patent number: 6846497Abstract: This invention relates to a starch based tablet disintegrant useful at low addition levels and providing equally effective properties in water and physiological fluids. The starches are characterized by their low solubility in cold water, high swelling power and labile birefringence in the dry state, which rapidly disappears upon addition of water. The preferred starches are inhibited then processed to remove a portion of the granular structure.Type: GrantFiled: January 30, 2003Date of Patent: January 25, 2005Assignee: National Starch and Chemical Investment Holding CorporationInventors: Monika K. Okoniewska, James J. Kasica, Eric M. Weisser
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Publication number: 20040266728Abstract: A method of making a carboxylated carbohydrate is disclosed, cellulose being a preferred carbohydrate material. Carboxylated cellulose fibers can be produced whose fiber strength and degree of polymerization is not significantly sacrificed. The method involves the use of a catalytic amount of a hindered cyclic oxammonium compounds as a primary oxidant and chlorine dioxide as a secondary oxidant in an aqueous environment. The oxammonium compounds may be formed in situ from their corresponding amine, hydroxylamine, or nitroxyl compounds. The oxidized cellulose may be stabilized against D.P. loss and color reversion by further treatment with an oxidant such as sodium chlorite or a chlorine dioxide/hydrogen peroxide mixture. Alternatively it may be treated with a reducing agent such as sodium borohydride. In the case of cellulose the method results in a high percentage of carboxyl groups located at the fiber surface.Type: ApplicationFiled: August 30, 2004Publication date: December 30, 2004Inventors: Joseph Lincoln Komen, S. Ananda Weerawarna, Richard A. Jewell
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Patent number: 6831173Abstract: A process for producing aldehydes, and/or carboxylic acids is described, in which a primary alcohol, especially a carbohydrate, is oxidized using a catalytic amount of a nitrosonium compound obtained by oxidizing a nitroxyl compound in the presence of an enzyme compound capable of oxidation. Further described are oxidized carbohydrates containing at least 1 cyclic monosaccharide chain group carrying a carbaldehyde group per 25 monosaccharide units and per molecule.Type: GrantFiled: November 26, 2001Date of Patent: December 14, 2004Assignee: Nederlandse Organisatie voor Toegepast-Natuurwetenschappelijk Onderzoek TNOInventors: Jan Matthijs Jetten, Ronald Tako Marinus Van Den Dool, Wim Van Hartingsveldt, Mario Tarcisius Raymundus Van Wandelen
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Patent number: 6828310Abstract: Disclosed is a composition that includes a material that is susceptible to degradation and a preserving agent in an amount effective to preserve the material comprising one or more reduced malto-oligosaccharide species. The preserving agent can include a single reduced malto-oligosaccharide species or a plurality of such species. Further disclosed is a method of preserving a material. The method generally includes contacting the material with a preserving agent containing a preserving effective amount of one or more reduced malto-oligosaccharide species. Solutions, powders, glasses, gels, and the like containing the chemically reactive material(s) and a preserving effective amount of one or more reduced malto-oligosaccharide species may be prepared.Type: GrantFiled: February 6, 2003Date of Patent: December 7, 2004Assignee: Grain Processing CorporationInventors: Frank W. Barresi, Richard L. Antrim
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Patent number: 6822091Abstract: The invention relates a process of oxidizing starch wherein a root or tuber starch comprising at least 95 wt. % based on dry substance of the starch amylopectin, or a derivative therof, is treated with hydrogen peroxide in the presence of a catalyst, which catalyst comprises divalent copper ions. The present invention further relates to an oxidizable starch obtainable by a process comprising treating a starch with hydrogen peroxide in the presence of a catalyst, which catalyst comprises divalent copper ions.Type: GrantFiled: March 29, 2001Date of Patent: November 23, 2004Assignee: Cooperative Verkoop-en Productievereniging van Aardappelmeel en Derivaten AVEBE B.A.Inventors: Ronald Peter W. Kesselmans, Ido Pieter Bleeker
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Patent number: 6790840Abstract: A hydrogel composition and methods of preparing and using the same are disclosed. The hydrogel composition comprises an oxidized polysaccharide, and a cross-linker having at least two functional cross-linking groups. The cross-linker reversibly cross-links the polysaccharide and is provided in an amount to provide dangling cross-linkers. The method of preparing a hydrogel comprises the steps of providing an oxidized polysaccharide, and providing a cross-linker having at least two functional cross-linking groups. The cross-linker is mixed with the polysaccharide at a concentration of the cross-linker sufficient to form a hydrogel wherein the cross-linker reversibly cross-links the polysaccharide and has dangling cross-linkers. The hydrogels are useful, for example, for tissue engineering, cell transplantation and drug delivery applications.Type: GrantFiled: November 27, 2000Date of Patent: September 14, 2004Assignee: The Regents of the University of MichiganInventors: Kuen Yong Lee, David J. Mooney
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Patent number: 6780852Abstract: The invention relates to polysaccharides, polysaccharide conjugates and complexes with altered biological properties, and methods to produce these polysaccharides, polysaccharide conjugates and complexes.Type: GrantFiled: November 12, 2002Date of Patent: August 24, 2004Inventors: Bo E. Hedlund, Thomas P. Weber, Paul R. Dragsten, Gregory J. Hanson, Philip E. Hallaway