Addition Compounds Patents (Class 536/16)
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Patent number: 11623939Abstract: The present invention is directed to a process for purifying natamycin, to an all-trans polyene amphoteric macrolide, to a composition comprising said polyene amphoteric macrolide and to a process for preparing said polyene amphoteric macrolide.Type: GrantFiled: August 15, 2019Date of Patent: April 11, 2023Assignee: DSM IP ASSETS B.V.Inventors: Alexander Lucia Leonardus Duchateau, Peter Philip Lankhorst, Willebrordus Bernardus Van Scheppingen
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Patent number: 11591360Abstract: The present invention is directed to a process for purifying natamycin, to an epoxide polyene amphoteric macrolide, to a composition comprising said polyene amphoteric macrolide and to a process for preparing said polyene amphoteric macrolide.Type: GrantFiled: August 15, 2019Date of Patent: February 28, 2023Assignee: DSM IP ASSETS B.V.Inventors: Alexander Lucia Leonardus Duchateau, Peter Philip Lankhorst, Willebrordus Bernardus Van Scheppingen
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Publication number: 20140323422Abstract: The invention relates to anionic conjugates of glycosylated bacterial metabolites that may be used to mimic the structure and/or activity of the anionic bioactive molecules known as glycosaminoglycans (GAGs). The invention also relates to processes for the preparation of the conjugates. Such conjugates are useful in the prophylaxis and/or treatment of disease conditions and in particular chronic disease conditions such as inflammatory (including allergic) diseases, metastatic cancers and infection by pathogenic agents including bacteria, viruses or parasites.Type: ApplicationFiled: July 10, 2014Publication date: October 30, 2014Inventors: Warren Charles KETT, Yugang CHEN
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Publication number: 20110311593Abstract: The invention relates to N-hydroxylated amidines, guanidines and aminohydrazones for application on the skin. In particular, the invention relates to transdermal therapeutic systems containing N-hydroxylated amidines, guanidines and aminohydrazones as a prodrug, and to methods for producing and using such systems.Type: ApplicationFiled: February 5, 2010Publication date: December 22, 2011Inventors: Rudolf Matusch, Hans-Rainer Hoffmann, Bodo Asmussen, Andreas Koch
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Patent number: 7417109Abstract: Disclosed are novel polymers derivatized with at least one —NOx group per 1200 atomic mass unit of the polymer. X is one or two. In one embodiment, the polymer is an S-nitrosylated polymer and is prepared by reacting a polythiolated polymer with a nitrosylating agent under conditions suitable for nitrosylating free thiol groups. The polymers of the present invention can be used to coat medical devices to deliver nitric oxide in vivo to treatment sites.Type: GrantFiled: August 7, 2006Date of Patent: August 26, 2008Assignee: Duke UniversityInventors: Jonathan S. Stamler, Eric J. Toone, Richard S. Stack
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Patent number: 6515112Abstract: A 99mTc complex which contains the moiety Tc═NR, Tc—N═NY or Tc(—N═NY)2, and as a synthetic organic ligand which confers biological target-seeking properties on the technetium complex, where: R is an aryl group, a substituted or unsubstituted alkyl group or the group —NR1R2; Y is an aryl group or a substituted or unsubstituted alkyl group; R1 and R2 are H, aryl groups or substituted or unsubstituted aliphatic or cyclic alkyl groups, and are the same or different provided that both are not hydrogen; where at least one of the R or Y groups comprises an aryl group which chelates the 99mTc.Type: GrantFiled: October 15, 2001Date of Patent: February 4, 2003Assignee: Amersham PLCInventors: Colin M. Archer, Jonathan R. Dilworth, Panna Jobanputra, Ian A. Latham, Russell M. Thompson
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Patent number: 6329513Abstract: A 99mTc complex which contains the moiety Tc═NR, Tc—N═NY or Tc(—N═NY)2, and as a synthetic organic ligand which confers biological target-seeking properties on the technetium complex, where: R is an aryl group, a substituted or unsubstituted alkyl group or the group —NR1R2; Y is an aryl group or a substituted or unsubstituted alkyl group; R1 and R2 are H, aryl groups or substituted or unsubstituted aliphatic or cyclic alkyl groups, and are the same or different provided that both are not hydrogen; where at least one of the R or Y groups comprises an aryl group which chelates the 99mTc.Type: GrantFiled: May 11, 2000Date of Patent: December 11, 2001Assignee: Nycomed Amersham plcInventors: Colin M. Archer, Jonathan R. Dilworth, Panna Jobanputra, Ian A. Latham, Russell M. Thompson
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Patent number: 6300481Abstract: The present invention provides an optically functional material comprising a rare-earth complex represented by the formula (I) wherein M is a rare-earth atom, n1 is 2 or 3, n2 is 2, 3 or 4, R is a C1-C20 group containing no H, X is a Group IVA atom, Group VA atom other than nitrogen or Group VIA atom other than oxygen, n3 is 0 or 1, and Y is C-Z′ (wherein Z′ is D, a halogen or C1-C20 group containing no H), N, P, As, Sb or Bi, or by the formula (II) wherein N, R, X, n1, n2 and n3 are as defined above.Type: GrantFiled: September 10, 1999Date of Patent: October 9, 2001Assignee: New Japan Chemical Co., Ltd.Inventors: Shozo Yanagida, Yasuchika Hasegawa, Yuji Wada, Tatsuhiko Yamanaka, Takashi Okubo
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Patent number: 4645760Abstract: Aminoglycosides and aminoglycoside-aminocyclitols which have been oxygen-radical activated show a broad spectrum of antibacterial activity. The activated compounds are able to penetrate the cell membranes of bacteria and show substantially enhanced activity as compared to the parent unactivated compound.Type: GrantFiled: July 20, 1983Date of Patent: February 24, 1987Assignee: Health Research Inc.Inventor: Martha Pierson
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Patent number: 4473557Abstract: A new semi-synthetic antibiotic, 3"-deoxystreptomycin is now provided, which is useful as an antibacterial agent and is produced from 3"-deoxydihydrostreptomycin by a process comprising oxidizing the 3'-hydroxymethyl group of 2,5,6,4",6"-penta-O-acetyl-2"-N-benzyloxycarbonyl-3"-deoxydihydrostreptomy cin as prepared by skilled introduction of amino-protecting group and hydroxyl-protecting group of appropriately selected natures into 3"-deoxydihydrostreptomycin, and then removing the protective groups from the oxidation product, 2,5,6,4",6"-penta-O-acetyl-2"-N-benzyloxycarbonyl-3"-deoxystreptomycin.Type: GrantFiled: March 9, 1983Date of Patent: September 25, 1984Assignee: Zaidan Hojin Biseibutsu Kagaku Kenkyu KaiInventors: Hamao Umezawa, Sumio Umezawa, Tsutomu Tsuchiya, Takayuki Usui
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Patent number: 4469683Abstract: New semi-synthetic antibiotics, 3"-epistreptomycin and 3"-epidihydrostreptomycin are now provided, which are useful as antibacterial agents. 3"-Epidihydrostreptomycin is produced by a process comprising hydrolyzing an appropriately N,O-protected 2",3"-N,O-carbonyl-3"-epidihydrostreptomycin which is prepared by skilled introduction of amino-protecting groups and hydroxyl-protecting groups of appropriately selected natures into dihydrostreptomycin and intermolecular condensation of a particular pair of amino-protecting and hydroxyl-protecting groups so introduced. 3"-Epistreptomycin is produced by a process comprising oxidizing the 3'-hydroxymethyl group of an appropriately N,O-protected 3"-epidihydrostreptomycin as prepared by skilled introduction of amino-protecting groups and hydroxyl-protecting groups of appropriately selected natures, and then removing the remaining protective groups from the resultant N,O-protected 3"-epistreptomycin obtained as the oxidation product.Type: GrantFiled: March 10, 1983Date of Patent: September 4, 1984Assignee: Zaidan Hojin Biseibutsu Kagaku Kenkyu KaiInventors: Hamao Umezawa, Sumio Umezawa, Tsutomu Tsuchiya, Tetsuo Shitara, Shuichi Sakamoto