Abstract: Novel lincomycin derivatives are disclosed. These lincomycin derivatives exhibit antibacterial activity. The compounds of the subject invention may exhibit potent activities against bacteria, including Gram positive organisms, and may be useful antimicrobial agents. Methods of synthesis and of use of the compounds are also disclosed.
Type:
Grant
Filed:
November 17, 2004
Date of Patent:
August 14, 2007
Assignee:
Vicuron Pharmaceuticals, Inc.
Inventors:
Jason G. Lewis, Sampath K. Anandan, Hardwin O'Dowd, Mikhail F. Gordeev
Abstract: Novel lincomycin derivatives are disclosed. These lincomycin derivatives exhibit antibacterial activity. The compounds of the subject invention may exhibit potent activities against bacteria, including gram positive organisms, and may be useful antimicrobial agents. Methods of synthesis and of use of the compounds are also disclosed.
Type:
Grant
Filed:
June 17, 2004
Date of Patent:
April 3, 2007
Assignee:
Vicuron Pharmaceuticals, Inc.
Inventors:
Jason G. Lewis, Sampath-Kumar Anandan, Hardwin O'Dowd, Mikhail F. Gordeev
Abstract: A process of purifying phosphoramidite precursors useful in inter alia synthesis of oligonucleotides comprises dissolving a crude phosphoramidite in a polar phase, adding a basic compound to the polar phase, adding a portion of water to the polar phase, contacting the polar phase with a first apolar phase to extract impurity into the apolar phase, separating the first apolar phase from the polar phase, adding a second aliquot of water to the polar phase, and contacting the polar phase with a second apolar phase, whereby the phosphoramidite partitions into the second apolar phase.