Abstract: The invention relates to a carbohydrate derivative having formula I
wherein R1 is (1-4C)alkoxy; R2, R3 and R4 are independently (1-4C)alkoxy or OSO3−, the total number of sulfate groups is 4, 5, or 6; and the twisted lines represent bonds either above or below the plane of the six-membered ring to which they are attached; or a pharmaceutically acceptable salt thereof.
The compounds of the invention have antithrombotic activity and may be used for treating or preventing thrombosis and for inhibiting smooth muscle cell proliferation.
Type:
Grant
Filed:
November 18, 1998
Date of Patent:
January 16, 2001
Assignee:
Akzo Nobel N.V.
Inventors:
Constant Adriaan Anton van Boeckel, Maurice Petitou, Philippe Duchaussoy, Cornelia Maria Dreef-Tromp, Johannes Egbertus Maria Basten
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