Plural Oxyalkylene Groups Bonded Directly To Each Other Patents (Class 536/18.3)
-
Publication number: 20150038436Abstract: The present disclosure provides for methods and compositions comprising a series of synthetic glycopolymers. The disclosure also relates to a kit which is suitable for carrying out the inventive methods.Type: ApplicationFiled: August 1, 2014Publication date: February 5, 2015Inventors: Young In Oh, Linda C. Hsieh-Wilson
-
Patent number: 8907070Abstract: Glycolipids of branched chain alkyl oligosaccharides include a primary alcohol branched in the 2-position and an oligosaccharide, covalently bond to the alcohol in either ?- or ?-linkage (shown in Formula I and Formula II). These compounds show phase behavior not found for the corresponding straight chain counterparts. The properties involve an ambient temperature liquid crystalline appearance and thermotropic liquid crystal phase polymorphism. The formation of cubic phases is considered most interesting with respect to life science applications, e.g. liposomes for drug delivery. Depending on the choice of sugar head group and alkyl tail, various levels of water miscibility may be adjusted to meet applications requirements (complete solubility for emulsifier applications, e.g. cosmetic creams, to limited water swelling only, e.g. for the preparation of artificial membranes).Type: GrantFiled: November 5, 2012Date of Patent: December 9, 2014Assignee: Universiti MalayaInventors: Rauzah Hashim, Thorsten Heidelberg, Hind Hassan, Nasrul Zamani Mohd Rodzi, Rusnah Syahila Dauli Hussen, Ahmad Sazali Hamzah, Shahidan Radiman, Volkmar Vill, Matthias Wulf, Seiji Ujiie
-
Patent number: 8865923Abstract: A method for separating neutral and polar lipids from an oil of biological material, wherein the oil is fractionated using a mixture of a polar solvent comprising at least one carbon atom, water and an additional substance selected from the group consisting of: mono-, di- and oligosaccharides comprising from 3 to 10 monosaccharide units, said additional substance is present in an amount of at least 0.1 wt % calculated on the total weight of solvent, water and additional substance, to form at least two liquid fractions having different densities, wherein one fraction is rich in polar lipids and another fraction is rich in neutral lipids. An oil rich in polar lipids obtained from the method is disclosed, said oil I contains at least 40, preferably at least 50 lipid % polar lipids as calculated on the total amount of lipids in said oil and that the total amount of polar solvent and water in said oil is between 20 and 30 wt %. An oat oil containing high amounts of estolides of DGDG can further be obtained.Type: GrantFiled: March 10, 2010Date of Patent: October 21, 2014Assignee: Swedish Oat Fiber ABInventor: Magnus Härröd
-
Patent number: 8828952Abstract: The invention relates to novel compounds that have utility as inhibitors of heparan sulfate-binding proteins; compositions comprising the compounds, and use of the compounds and compositions thereof for the antiangiogenic, antimetastatic, anti-inflammatory, antimicrobial, anticoagulant and/or antithrombotic treatment of a mammalian subject.Type: GrantFiled: October 16, 2008Date of Patent: September 9, 2014Assignee: Progen Pharmaceuticals LimitedInventors: Vito Ferro, Tomislav Karoli, Ligong Liu, Paul Newton Handley, Kenneth David Johnstone, Norbert Wimmer, Edward Timothy Hammond
-
Patent number: 8304525Abstract: Glycolipids of branched chain alkyl oligosaccharides according to this patent comprise of a primary alcohol branched in the 2-position and an oligosaccharide, covalently bond to the alcohol in either ?- or ?-linkage (shown in Formula I and Formula II). These compounds show particularly interesting phase behavior not found for the corresponding straight chain counterparts. The properties involve an ambient temperature liquid crystalline appearance and thermotropic liquid crystal phase polymorphism. Upon the latter, the formation of cubic phases is considered most interesting with respect to life science applications, e.g. liposome for drug delivery. Depending on the choice of sugar head group and alkyl tail, various levels of water miscibility may be adjusted to meet applications requirements (complete solubility for emulsifier applications, e.g. cosmetic creams, to limited water swelling only, e.g. for the preparation of artificial membranes).Type: GrantFiled: February 20, 2006Date of Patent: November 6, 2012Assignee: Universiti MalayaInventors: Rauzah Hashim, Thorsten Heidelberg, Hind Hassan, Nasrul Zamani Mohd Rodzi, Rusnah Syahila Dauli Hussen, Ahmad Sazali Hamzah, Shahidan Radiman, Volkmar Vill, Matthias Wulf, Seiji Ujiie
-
Patent number: 8298436Abstract: Fire extinguishing compositions and methods of extinguishing a fire comprising compounds of formula (I) where Rf is a fluorocarbon group. The compounds and compositions described herein are useful as intermediates in the preparation of or as additives to AFFF (aqueous film forming foam) formulations used for the extinguishment of fuel and solvent fires.Type: GrantFiled: October 14, 2008Date of Patent: October 30, 2012Assignee: Ansul, IncorporatedInventor: Jeffrey D. Michael
-
Patent number: 8173606Abstract: The invention relates to compounds which are polysulfated oligosaccharide derivatives having activity as inhibitors of heparan sulfate-binding proteins and inhibitors of the enzyme heparanase; methods for the preparation of the compounds; compositions comprising the compounds, and use of the compounds and compositions thereof for the antiangiogenic, antimetastatic, anti-inflammatory, antimicrobial, anticoagulant and/or antithrombotic treatment, lowering of blood triglyceride levels and inhibition of cardiovascular disease of a mammalian subject.Type: GrantFiled: December 3, 2010Date of Patent: May 8, 2012Assignee: Progen Pharmaceuticals LimitedInventors: Vito Ferro, Jon Krueger Fairweather, Tomislav Karoli, Ligong Liu
-
Publication number: 20120095198Abstract: A method for separating neutral and polar lipids from an oil of biological material, wherein the oil is fractionated using a mixture of a polar solvent comprising at least one carbon atom, water and an additional substance selected from the group consisting of: mono-, di- and oligosaccharides comprising from 3 to 10 monosaccharide units, said additional substance is present in an amount of at least 0.1 wt % calculated on the total weight of solvent, water and additional substance, to form at least two liquid fractions having different densities, wherein one fraction is rich in polar lipids and another fraction is rich in neutral lipids. An oil rich in polar lipids obtained from the method is disclosed, said oil I contains at least 40, preferably at least 50 lipid % polar lipids as calculated on the total amount of lipids in said oil and that the total amount of polar solvent and water in said oil is between 20 and 30 wt %. An oat oil containing high amounts of estolides of DGDG can further be obtained.Type: ApplicationFiled: March 10, 2010Publication date: April 19, 2012Applicant: Swedish Oat Fiber ABInventor: Magnus Harrod
-
Publication number: 20110130354Abstract: The invention relates to compounds which are polysulfated oligosaccharide derivatives having activity as inhibitors of heparan sulfate-binding proteins and inhibitors of the enzyme heparanase; methods for the preparation of the compounds; compositions comprising the compounds, and use of the compounds and compositions thereof for the antiangiogenic, antimetastatic, anti-inflammatory, antimicrobial, anticoagulant and/or antithrombotic treatment, lowering of blood triglyceride levels and inhibition of cardiovascular disease of a mammalian subject.Type: ApplicationFiled: December 3, 2010Publication date: June 2, 2011Applicant: Progen Pharmaceuticals LimitedInventors: Vito Ferro, Jon Krueger Fairweather, Tomislav Karoli, Ligong Liu
-
Publication number: 20110105379Abstract: Conjugates of a saccharide and a biomolecule, covalently linked therebetween via a non-hydrophobic linker and methods of preparing same are disclosed. Also disclosed are medical uses utilizing such conjugates. Glycosylation reagents for use in preparing these conjugates are also disclosed. Glycosylated proteins, characterized by improved performance, are also disclosed.Type: ApplicationFiled: August 20, 2008Publication date: May 5, 2011Applicant: Protalix Ltd.Inventors: Avidor Shulman, Ilya Ruderfer
-
Publication number: 20100292191Abstract: The invention is related to alkylene oxide adducts of oligosaccharides, obtained by a process comprising alkoxylating at least one water-soluble oligosaccharide in aqueous solution at a temperature in the range of 90 to 160° C. The compounds are useful as adjuvants in agrochemical compositions.Type: ApplicationFiled: December 11, 2008Publication date: November 18, 2010Applicant: COGNIS IP MANAGEMENT GMBHInventors: Hans-Georg Mainx, Peter Hofer
-
Patent number: 7812142Abstract: The present invention relates to pentose and pentose derivatives that are effective at increasing glucose transport in a non-insulin dependent manner, and to uses thereof for a) treating and/or preventing hyperglycemia; b) treating and/or preventing the complications of hyperglycemia; c) treating diabetes; d) increasing the rate of cellular glucose transport; e) increasing the rate of cellular glucose uptake; f) improving the ability of a subject to metabolize glucose; g) treating daily blood glucose fluctuations; h) reducing blood sugar levels; i) reducing the dosage of anti-diabetic medication needed for treatment of diabetes. The present invention further provides novel pentose derivatives having beneficial properties in terms of pharmacokinetics, to pharmaceutical compositions comprising these novel compounds and uses thereof.Type: GrantFiled: April 19, 2005Date of Patent: October 12, 2010Assignees: Yissum Research Development Company of the Hebrew University of Jerusalem, Hadasit Medical Research Services and Development Ltd.Inventors: Shlomo Sasson, Erol Cerasi, Arie Gruzman, Joshua Katzhendler
-
Publication number: 20100190969Abstract: Non-naturally occurring carbohydrate-based fibrous elements and more particularly, non-naturally occurring carbohydrate-based fibrous elements having a macrostructure and a microstructure wherein the microstructure is visible when wet and methods for making same are provided.Type: ApplicationFiled: January 21, 2010Publication date: July 29, 2010Inventor: Dean Van Phan
-
Publication number: 20100166695Abstract: Designed herein are multivalent heterobifunctional polymers for binding to a biological target exhibiting biological activity and to an effector template which can affect the biological activity of the biological target or detect the presence of the biological target. The polymers comprise a plurality of pre-arranged heterobifunctional ligands connected thereto, and each heterobifunctional ligand comprises a first functionality capable of binding to the biological target, and a second functionality capable of binding to the effector template. The heterobifunctional ligands are pre-arranged on the polymer so as to form a ternary complex between the polymer, the biological target and the effector template. The polymers, methods and compositions described herein provide an approach for the design and production of new therapeutic agents as well as agents useful in a variety of non-therapeutic applications.Type: ApplicationFiled: March 20, 2008Publication date: July 1, 2010Applicant: THE GOVERNORS OF THE UNIVERSITY OF ALBERTAInventors: David R. Bundle, Pavel kitov
-
Patent number: 7285647Abstract: A mixture of fatty acid esters of ethoxylated alkylglucosides of formula I is useful as a refatting agent in cosmetic formulations.Type: GrantFiled: June 13, 2003Date of Patent: October 23, 2007Assignee: The Lubrizol CorporationInventors: Carmella A. Barbeito, Stuart Barry Polovsky, Lowell Kreeger
-
Patent number: 6958314Abstract: A petro-chemical free nonionic surfactant is prepared by the alkylation of an alkyl polyglucoside (APG). Under suitable alkylation reaction conditions, the surfactants are preferably prepared by the reaction of an APG with either alkyl halide or an alkyl tosylate. These surfactants are low foaming and exhibit excellent detergency.Type: GrantFiled: March 5, 2003Date of Patent: October 25, 2005Assignee: Master Chemical CorporationInventor: David B. McCall
-
Patent number: 6919071Abstract: The invention concerns a cosmetic or dermatological composition for protection against ultraviolet radiation, based on inorganic screening agent, characterized in that it comprises a water-in-oil emulsion containing a combination of at least a particulate inorganic sunscreening agent, selected among the group consisting of titanium dioxide, zinc oxide and mixtures thereof, and at least an emulsifier selected among the group consisting of silicone derivatives with glycosidic constituent, the particulate screening agent being homogeneously dispersed in the water-in-oil emulsion.Type: GrantFiled: April 4, 2001Date of Patent: July 19, 2005Assignee: Laboratoires ExpanscienceInventors: Jean-Christophe Choulot, Nathalie Petit, Philippe Msika, Patricia Ferraris, Delphine Ribes, Jocelyne Hilaire, Bernard Ribes
-
Patent number: 6723836Abstract: To provide low odor polyoxyalkylene polyol, a process for producing the same, and a low odor urethane prepolymer and a low odor urethane composition using the same as a raw material. The low odor polyoxyalkylene polyol comprising polyoxyalkylene polyol with amine added thereto, the amine having at least one amino group represented by the following formula (1): is provided, wherein R1, R2 and R3 independently represent hydrogen atom or an organic group which may contain a hetero atom in which an atom bonded to nitrogen atom is carbon atom.Type: GrantFiled: April 20, 2000Date of Patent: April 20, 2004Assignee: The Yokohama Rubber Co., Ltd.Inventors: Kiminori Araki, Kazunori Ishikawa
-
Patent number: 6713454Abstract: The present invention provides amphiphilic prodrugs comprising a therapeutic compound conjugated to an PEG-oligomer/polymer and methods for using said prodrugs to enable oral drug delivery and/or delivery of drugs across the blood brain barrier into the central nervous system.Type: GrantFiled: December 31, 1999Date of Patent: March 30, 2004Assignee: Nobex CorporationInventors: Nnochiri Ekwuribe, Christopher H. Price, Tatyana A. Dyakonov
-
Patent number: 6664235Abstract: A medicament for treatment of a viral infection which comprises as an active ingredient a compound represented by the following formula (I) or its Pharmaceutically acceptable salt, or a hydrate thereof or a solvate thereof.Type: GrantFiled: August 18, 2000Date of Patent: December 16, 2003Assignee: RikenInventors: Osamu Kanie, Chi-Huey Wong, Yasuo Suzuki
-
Patent number: 6541614Abstract: Polysaccharide derivatives derived from a polysaccharide or a derivative thereof by substituting a part or all of the hydrogen atoms of the hydroxyl groups of the polysaccharide or the derivative thereof with the groups represented by the following formula (1): —E1—(OA)n—E2—R (1) wherein E1 represents a divalent saturated C1-6 hydrocarbon group which may be substituted with one or more hydroxyl groups or oxo groups, n stands for a number of from 8 to 300, n numbers of As may be the same or different and each independently represent a divalent saturated C1-6 hydrocarbon group, E2 represents an ether bond or an oxycarbonyl group, and R represents a C4-30 alkyl group which may be substituted with one or more hydroxyl groups, in which the H(s) of one or more hydroxy groups in each of said groups (1) may be further substituted with the groups (1); thickeners and emulsifiers comprising these polysaccharide derivatives; as well as aqueous compositions containing said polysacchariType: GrantFiled: December 3, 2001Date of Patent: April 1, 2003Assignee: Kao CorporationInventors: Atsushi Nagasawa, Tomohito Kitsuki, Takeshi Ihara
-
Patent number: 6380367Abstract: A continuous process for the formation of sucrose based polyols is disclosed. The process comprises the steps of continuously forming an aqueous sucrose solution which is continuously combined with a catalyst and an alkylene oxide and flowed through a first spiral reaction tube. The alkylene oxide substantially completely reacting with the aqueous sucrose solution occurs to form a pre-polymer reaction product in the first spiral reaction tube. The pre-polymer reaction product is continuously flowed from the first reaction tube and unreacted water from the pre-polymer reaction product is removed. The water stripped pre-polymer reaction product is continuously flowed through a second spiral reaction tube and additional alkylene oxide is continuously added to the second spiral reaction tube. The alkylene oxide reacts with the pre-polymer reaction product in the second spiral reaction tube to form a polyol.Type: GrantFiled: November 18, 1999Date of Patent: April 30, 2002Assignee: BASF CorporationInventors: Werner Hinz, Edward Michael Dexheimer