Abstract: Provided herein are alpha2-selective Na,K-ATPase inhibitors and prodrugs thereof, characterized by having a cyclic moiety attached to a digoxin or digitoxin derivative, as well as uses thereof in lowering intraocular pressure and in treating glaucoma and heart conditions.
Type:
Grant
Filed:
July 19, 2016
Date of Patent:
June 2, 2020
Assignee:
Yeda Research and Development Co. Ltd.
Inventors:
Steven J. D. Karlish, Adriana Katz, Daniel M. Tal, Arie Marcovich
Abstract: A steroid compound of the Formula (1): [wherein R1 represents a group selected from the group consisting of H, CH3, C2H5, C3H7 and CH (CH3)2, R2 represents a group selected from NH2, NHAc and OCOR1, R3 represents a group selected from the group consisting of CH3, COOCH3 and CH2OCOR1.
Abstract: The invention relates to a crystalline form of 1?-(1-methylethyl)-4?-[(2-fluoro-4-methoxyphenyl)methyl]-5?-methyl-1H-pyrazol-3?-O-?-D-glucopyranoside, to a method for the preparation thereof, as well as to the use thereof for preparing medicaments.
Type:
Grant
Filed:
January 10, 2007
Date of Patent:
April 28, 2009
Assignees:
Boehringer Ingelheim International GmbH, Ajinomoto Co., Inc.
Inventors:
Gerd Kraemer, Hans-Juergen Martin, Gebhard Adelgoss, Klaus Dugi, Adil Duran, Peter Eickelmann, Steffen Maier, Sabine Pinnetti, Regine Ritter, Gebhard Schilcher, Ruediger Streicher, Leo Thomas
Abstract: This invention provides for labeling reagents, labeled targets and processes for preparing labeling reagents. The labeling reagents can take the form of cyanine dyes, xanthene dyes, porphyrin dyes, coumarin dyes or composite dyes. These labeling reagents are useful for labeling probes or targets, including nucleic acids and proteins. These reagents can be usefully applied to protein and nucleic acid probe based assays. They are also applicable to real-time detection processes.
Type:
Application
Filed:
January 23, 2004
Publication date:
November 18, 2004
Applicant:
Enzo Life Sciences, Inc.
Inventors:
Jannis G. Stavrianopoulos, Elazar Rabban
Abstract: This invention provides for labeling reagents, labeled targets and processes for preparing labeling reagents. The labeling reagents can take the form of cyanine dyes, xanthene dyes, porphyrin dyes, coumarin dyes or composite dyes. These labeling reagents are useful for labeling probes or targets, including nucleic acids and proteins. These reagents can be usefully applied to protein and nucleic acid probe based assays. They are also applicable to real-time detection processes.
Type:
Application
Filed:
January 21, 2004
Publication date:
October 14, 2004
Applicant:
Enzo Life Sciences, Inc.
Inventors:
Jannis G. Stavrianopoulos, Elazar Rabbam
Abstract: This invention provides for labeling reagents, labeled targets and processes for preparing labeling reagents. The labeling reagents can take the form of cyanine dyes, xanthene dyes, porphyrin dyes, coumarin dyes or composite dyes. These labeling reagents are useful for labeling probes or targets, including nucleic acids and proteins. These reagents can be usefully applied to protein and nucleic acid probe based assays. They are also applicable to real-time detection processes.
Type:
Application
Filed:
January 23, 2004
Publication date:
September 9, 2004
Applicant:
Enzo Life Sciences, Inc.
Inventors:
Jannis G. Stavrianopoulos, Elazar Rabbani
Abstract: A nucleic acid based method is provided for the detection of methanogens in human, animal, plant and in environmental samples of soil, sediment or water that are terrestrial or subterranean in origin. The method is effected by (a) obtaining a biological sample; and (b) analyzing the sample for a nucleic acid sequence/s unique to methanogens, wherein a detectable level of the nucleic acid sequence unique to methanogens is indicative of the presence of methanogens in the sample. Further, a scheme for inferring the identity of the different types of methanogens is provided, wherein, the DNA sequences of the methyl reductase genes detected in that sample are compared to methyl reductase sequences of known methanogens. With this technology, methanogens in samples containing less than {fraction (1/1000)}th of a gram of biomass can be detected.
Type:
Application
Filed:
August 10, 2001
Publication date:
August 7, 2003
Inventors:
Mohankumar R. Sowlay, Stephen M. Hinton
Abstract: A method and composition for treating a host infected with flavivirus or pestivirus comprising administering an effective flavivirus or pestivirus treatment amount of a described 1′, 2′ or 3′-modified nucleoside or a pharmaceutically acceptable salt or prodrug thereof, is provided.