Abstract: The present invention provides compositions, systems and methods for demulsifying an emulsion including an aqueous phase and an organic phase by adding an effective amount of a composition comprising at least one quaternary organopolysiloxane or salt thereof to the emulsion, the composition optionally including at least one of quaternary epihalohydrin/polyamine copolymers or salts, and/or (poly)diallyldimethylammonium halides.
Type:
Grant
Filed:
September 5, 2012
Date of Patent:
August 5, 2014
Assignees:
Kroff Chemical Company, Dow Agrosciences LLC
Inventors:
Paul Rey, David M. Sunderlik, Steven P. Ceplecha
Abstract: New crystalline forms of macrolide compounds, and pharmaceutical compositions thereof, are described herein. In addition, processes for preparing the crystalline forms are described herein.
Abstract: The present invention provides compositions, systems and methods for demulsifying an emulsion including an aqueous phase and an organic phase by adding an effective amount of a composition comprising at least one quaternary organopolysiloxane or salt thereof to the emulsion, the composition optionally including at least one of quaternary epihalohydrin/polyamine copolymers or salts, and/or (poly)diallyldimethylammonium halides.
Type:
Grant
Filed:
April 3, 2009
Date of Patent:
September 18, 2012
Assignees:
DOW Agrosciences LLC, Kroff Chemical Company
Inventors:
Paul Rey, Steve P. Ceplecha, David M. Sunderlik
Abstract: Compositions and methods are provided for decreasing blood glucose levels in an animal or for preventing or delaying the onset of a rise in blood glucose levels in an animal, comprising administering to the animal an antisense inhibitor of PTP1B expression in combination with at least one glucose-lowering drug. The present invention is also directed to compositions and methods for improving insulin sensitivity in an animal or for preventing or delaying the onset of insulin resistance in an animal. Also provided are compositions and methods for treating or preventing a metabolic condition in an animal. The metabolic condition may be, e.g., diabetes or obesity.
Type:
Grant
Filed:
December 2, 2002
Date of Patent:
July 28, 2009
Assignee:
Euroimmun Medizinische Labordiagnostika AG
Inventors:
Waltraud Suer, Cornelia Dähnrich, Wolfgang Schlumberger, Winfried Stöcker
Abstract: A polymorphic form of clarithromycin (form V) which exhibits a characteristic X-ray diffraction pattern, a method for producing such polymorphic clarithromycin, and the use of such polymorphic clarithromycin to treat bacterial infections.
Abstract: This invention relates to a novel crystalline diphosphate salt of (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-13-[[2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(propylamino)methyl]-?-L-ribo-hexopryanosyl]oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-?-D-xylo-hexopyranosyl]oxy]-1-oxa-6-azacyclopentadecan-15-one that is useful as an antibacterial and antiprotozoal agent in mammals. This invention also relates to pharmaceutical compositions containing the free base of the diphosphate salt and the methods of treating bacterial and protozoal infections in mammals by administering the free base of the diphosphate to mammals requiring such treatment. The free base of the diphosphate salt of the present invention possesses potent activity against various bacterial and protozoal infections when given by parenteral application to mammals.
Type:
Grant
Filed:
May 6, 2004
Date of Patent:
November 20, 2007
Assignees:
Pfizer Inc., Pfizer Products Inc.
Inventors:
Robert J. Rafka, Colman B. Ragan, Douglas J. M. Allen
Abstract: This invention relates to a novel crystalline diphosphate salt of (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-13-[[2,6-dideoxy-3-C-methyl-3-o-methyl-4-C-[(propylamino)methyl]-?-L-ribo-hexopryanosyl]oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-?-D-xylo-hexopyranosyl]oxy]-1-oxa-6-azacyclopentadecan-15-one that is useful as an antibacterial and antiprotozoal agent in mammals. This invention also relates to pharmaceutical compositions containing the free base of the diphosphate salt and the methods of treating bacterial and protozoal infections in mammals by administering the free base of the diphosphate to mammals requiring such treatment. The free base of the diphosphate salt of the present invention possesses potent activity against various bacterial and protozoal infections when given by parenteral application to mammals.
Type:
Grant
Filed:
August 12, 2002
Date of Patent:
March 1, 2005
Assignee:
Pfizer, Inc.
Inventors:
Robert J. Rafka, Colman B. Ragan, Douglas J. M. Allen
Abstract: Clarithromycin can be easily prepared by reacting erythromycin A N-oxide with a methylating agent to obtain 6-O-methylerythromycin A N-oxide; and treating 6-O-methylerythromycin A N-oxide obtained above with a reducing agent in a high yield.
Type:
Grant
Filed:
May 1, 2002
Date of Patent:
October 26, 2004
Assignee:
Hanmi Pahrm. Co., Ltd.
Inventors:
Kwee-Hyun Suh, Mi-Ra Seong, Nam-Du Kim, Gwan-Sun Lee
Abstract: The present invention comprises the optimization of a four zone simulated moving bed system configured to separate a first component from a mixture containing the first component and a second component wherein the first component exhibits non-linear adsorption and non-negligible mass transfer resistances. In one example, the four zone simulated moving bed is optimized to separate Clarithromycin from a mixture containing Clarithromycin and 6,11-O-methyl erythromycin A. The present invention further comprises a four zone or a five zone apparatus having a first portion and a second portion and the optimization of the four zone or five zone apparatus to separate a first component from a mixture containing the first component and a second component and the method of using the same. In one example, the four zone and five zone simulated moving beds are optimized to separate Clarithromycin from a mixture containing Clarithromycin and 6,11-O-methyl erythromycin A.
Type:
Application
Filed:
May 31, 2002
Publication date:
December 11, 2003
Inventors:
Chad Farrenburg, Nien-Hwa Linda Wang, Yi Xie, Benjamin J. Hritzko
Abstract: A process for the purification of roxithromycin, an antibiotic for therapeutic purposes, in which the purification is carried out by the dissolution or suspension of the product in methanol followed by cooling. Purification may also be obtained by addition of a non-solvent and/or by concentration of the mixture, thus obtaining a purified product.
Type:
Grant
Filed:
August 11, 1999
Date of Patent:
March 20, 2001
Assignee:
Hovione Inter Ltd.
Inventors:
William Heggie, Alexandre Carvalho, Luis Sobral