Heavy Metal Or Aluminum Containing Patents (Class 540/3)
-
Patent number: 8963106Abstract: A method is provided for the thermal photoswitching of spin-transition compounds from the low-spin state to the high-spin state, including at least one step of exposing the material to a non-polarized laser beam which is at room temperature, and the wavelength of which is in the infrared range and the power of which is 1 mW·cm?2 to 1 W·cm?2. The method may be used for the temporary or permanent marking of materials including particles of at least one spin-transition compound including an iron(II) and triazole ligand compound.Type: GrantFiled: July 20, 2011Date of Patent: February 24, 2015Assignee: Centre National de la Recherche ScientifiqueInventors: Jean-Francois Letard, Eric Freysz
-
Publication number: 20140148425Abstract: Photosensitive compounds for use in a method of treating a disease or condition are described. The photosensitive compounds have the formula R—Y, wherein R is a ruthenium complex and Y is at least one sulphur-containing photoreleasable group, and the compounds comprise at least one ruthenium-sulphur bond; or a pharmaceutically acceptable salt, solvate, ester or amide, such that upon influence of visible or near infra-red light (400-1400 nm) in vivo, said at least one ruthenium-sulphur bond is broken, thereby generating a pharmacologically active compound.Type: ApplicationFiled: October 18, 2011Publication date: May 29, 2014Inventor: Sylvestre Bonnet
-
Patent number: 8709599Abstract: A material is composed of at least one spin transition compound that corresponds to the formula Fe1-mMm(R-Trz)3XbYc (I) in which M is a metal having a 3d4, 3d5, 3d6 or 3d7 configuration, other than Fe; 0?m?1; R-Trz represents a 1,2,4-triazole ligand carrying an R substituent on the nitrogen in the 4 position; R is an alkyl group or an R1R2N— group in which R1 and R2 represent, each independently of the other, H or an alkyl radical; X represents at least one noncoloring monovalent or divalent anion; Y represents at least one anion which has a coloring group; and b and c are chosen so that the electrical neutrality of the compound (I) is adhered to. A process for the preparation of this material and to its use as thermochromic pigment, as support for data storage or as optical limiter.Type: GrantFiled: June 11, 2008Date of Patent: April 29, 2014Assignee: Centre National de la Recherche ScientifiqueInventors: Jean-François Letard, Nathalie Daro, Sandie Auffret
-
Publication number: 20140058061Abstract: Described is a process for preparing platinum-carbene complexes.Type: ApplicationFiled: December 22, 2011Publication date: February 27, 2014Applicants: ULNIVERSITE DE STRASBOUGE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Stéphane Bellemin-Laponnaz, Gilles Guichard, Edith Chardon
-
Publication number: 20140046021Abstract: The molecular structures of metal-salen complexes which exerts pharmacological effects are clarified and the metal-salen complexes having such molecular structures and their derivatives are provided. A metal-salen complex compound is characterized in that a metal atom part in each of multiple molecules of the metal-salen complex or its derivative is multimerized via water.Type: ApplicationFiled: January 19, 2012Publication date: February 13, 2014Applicants: IHI CORPORATIONInventors: Yoshihiro Ishikawa, Haruki Eguchi
-
Publication number: 20120202774Abstract: The present invention provides acyloxy- and phosphoryloxy-butadiene-Fe(CO)3 complexes which can deliver carbon monoxide to a physiological target, wherein release of carbon monoxide can be enzymatically-triggered. The present invention also provides for methods of manufacturing the enzymatically-triggered carbon monoxide releasing molecules and methods for their use.Type: ApplicationFiled: February 4, 2011Publication date: August 9, 2012Applicants: UNIVERSITAET REGENSBURG, UNIVERSITAET ZU KOELNInventors: Hans-Guenther Schmalz, Steffen Romanski, Sabine Amslinger, Benito Yard, Birgit Kraus
-
Publication number: 20110201802Abstract: Disclosed is a compound characterized by comprising a linker, an oxygen-concentration-responsive phosphorophore which is linked to a first end of the linker, and a fluorophore which is lined to a second end of the linker. In the compound, it is preferred that the triplet level of the phosphorophore be lower than that of the fluorophore. The compound can be used as an oxygen-responsive luminescent probe.Type: ApplicationFiled: October 16, 2009Publication date: August 18, 2011Applicant: National University Corporation Gunma UniversityInventors: Seiji Tobita, Toshitada Yoshihara, Masahiro Hosaka, Toshiyuki Takeuchi
-
Publication number: 20100075314Abstract: The invention provides stable bioconjugate-nanoparticle probes which are useful for detecting nucleic acids and other target analytes, e.g., proteins, and methods of preparing those probes.Type: ApplicationFiled: May 26, 2009Publication date: March 25, 2010Inventors: Viswanadham Garimella, Thomas F. Holzman, Yijia P. Bao
-
Publication number: 20080305049Abstract: The invention relates to bifunctional conjugates comprising a receptor ligand moiety and a metal binding moiety and complexes thereof with paramagnetic lanthanide or transition metals, and to the use of the metal complexes as contrast agents in magnetic resonance imaging (MRI) of tumors and other abnormalities.Type: ApplicationFiled: January 31, 2006Publication date: December 11, 2008Inventors: Hadassa Degani, David Stein
-
Patent number: 7138520Abstract: In part, the present invention is directed to coordination complexes comprising a therapeutic agent. In one aspect, the subject compositions comprise a platinum metal center and a covalently attached therapeutic agent.Type: GrantFiled: January 12, 2004Date of Patent: November 21, 2006Assignee: Massachusetts Institute of TechnologyInventors: Stephen J. Lippard, Carmen M. Barnes, Ariel Haskel, Katie R. Barnes
-
Publication number: 20040242852Abstract: The invention concerns a ligand comprising (I) wherein n is an integer from 1 to 5 Y is CO2H or PO3H2T represents —X or -phenyl-X, wherein X represents NO2, NH2, NCS, NHCOCH2-Z, NHCO—W—COCNHS, —NH-Q, —NHCS-Q, —NHCOCH2-Q, or NHCO(CH2)m-Q where Q is a hapten chosen from the group consisting of steroids, enzymes, proteins, monoclonal antibodies, chimeric antibodies, or fragments thereof or any activated linker ready for coupling reaction, W is —(CH2)m- m is an integer from 1 to 10 Z is chloride, bromide or iodine.Type: ApplicationFiled: March 16, 2004Publication date: December 2, 2004Inventors: Ali Ouadi, Jean-Francois Gestin, Christos Apostolidis
-
Patent number: 6803030Abstract: Compounds able to chelate paramagnetic metal ions and the use thereof as contrast agents in the technique known as “Magnetic Resonance Imaging” (M.R.I.).Type: GrantFiled: August 27, 2002Date of Patent: October 12, 2004Assignee: Bracco Imaging S.p.A.Inventors: Christoph De Haen, Andrea Beltrami, Enrico Cappelletti, Luciano Lattuada, Mario Virtuani
-
Publication number: 20030225247Abstract: This invention provides for labeling reagents, labeled targets and processes for preparing labeling reagents. The labeling reagents can take the form of cyanine dyes, xanthene dyes, porphyrin dyes, coumarin dyes or composite dyes. These labeling reagents are useful for labeling probes or targets, including nucleic acids and proteins. These reagents can be usefully applied to protein and nucleic acid probe based assays. They are also applicable to real-time detection processes.Type: ApplicationFiled: March 12, 2002Publication date: December 4, 2003Inventors: Jannis G. Stavrianopoulos, Elazar Rabbani
-
Publication number: 20020098152Abstract: Substituted polycarboxylic ligand molecules and corresponding metal complexes of said ligands, preferably paramagnetic metals complexes for generating responses in the field of magnetic resonance imaging (MRI)Type: ApplicationFiled: December 14, 2001Publication date: July 25, 2002Applicant: Bracco International B.V.Inventors: Pier Lucio Anelli, Luciano Lattuada, Fulvio Uggeri, Giovanna Lux, Michele Serleti, Milena Gabellini, Herve Tournier
-
Patent number: 5725840Abstract: The present invention relates to metabolically labile esters, and to contrast media for X-ray and magnetic resonance imaging comprising these esters. The esters have formula (I): ##STR1## in which R.sup.3 is asteroid residue. The esters contain at least one iodine atom and/or heavy metal atom. The compound are metabolizable to products which are soluble in body fluids and are physiologically acceptable.Type: GrantFiled: October 4, 1996Date of Patent: March 10, 1998Assignee: Nycomed Imaging ASInventors: Jo Klaveness, Frode Rise, John Varadarajan, Arne J.o slashed.rgen Aasen
-
Patent number: 5602236Abstract: Metal-containing steroid mimic complexes are provided. Compositions containing a metal ion incorporated into a steroid skeleton structure and ligands useful in the preparation of such compositions are also provided. The metal ion is preferably a radionuclide, such as technetium, rhenium or gallium. Methods for using the metal complexes for diagnostic and therapeutic purposes are further provided.Type: GrantFiled: April 8, 1994Date of Patent: February 11, 1997Assignee: Mallinckrodt Medical, Inc.Inventor: Raghavan Rajagopalan
-
Patent number: 5358940Abstract: Naphthalocyanine-chelate complexes of formula I ##STR1## are described which contain as central atom M aluminum, gallium, indium, fin, ruthenium or preferably germanium and in which the remaining symbols are as defined in claim 1. The complexes can be used inter alia in the photodynamic chemotherapy of tumors.Type: GrantFiled: February 25, 1993Date of Patent: October 25, 1994Assignee: Ciba-Geigy CorporationInventors: Hans G. Capraro, Marcus Baumann
-
Patent number: 5338857Abstract: Aminoketone derivative compounds containing a heterocyclic ring bonded to an aminoketone moiety and useful as effective ingredients of centrally acting muscle relaxants and pollakiurea curing agents.(+)3-phenyl-5-[2-(1-pyrrolidinylmethyl)butyryl]isoxazole, which has a more remarkable central muscle relaxant action as compared with its racemic modification, can be effectively separated from the racemic modification using optically active 10-camphorsulfonic acid as the agent for the optical resolution.Type: GrantFiled: February 24, 1992Date of Patent: August 16, 1994Assignee: Mitsui Toatsu Chemicals IncorporatedInventors: Norio Ohto, Kazutoshi Horikomi, Akira Matsubara, Hideki Tanada, Kazuya Sakai, Seitaro Kajiya, Akira Mizuchi, Hideshi Shimizu
-
Patent number: 5262526Abstract: A fluorescent compound, which is readily capable of forming a stable complex with a rare-earth metal ion having fluorescence with satisfactory intensity even in an aqueous system and long fluorescence lifetime when formed a complex with the rare-earth metal ion, a complex of the fluorescent compound and the rare-earth metal ion, and a labelled reagent made therefrom, together with a specific binding assay using said labelling agent.A fluorescent compound expressed by the following formula A, typically exemplified by 2,15-diaza[3,3](2,9)-1,10-phenanthrolinophane-N.sup.2,N.sup.15 -diacetic acid.Type: GrantFiled: December 20, 1991Date of Patent: November 16, 1993Assignees: Dojindo Laboratories, Mochida Pharmaceutical Co., Ltd.Inventors: Kazumi Sasamoto, Daikichi Horiguchi, Masahiro Nobuhara, Hiroshi Mochizuki
-
Patent number: 5245026Abstract: The present invention provides linear, cyclic and trifurcate tri- and tetramine backbone multidentate chelating agents based on the 8-hydroxyquinoline chelating unit. The chelating agents may optionally be substituted with a substrate reactive moiety and antibody-metal ion conjugates may be produced for in vivo diagnostic and therapeutic methods.Type: GrantFiled: May 21, 1991Date of Patent: September 14, 1993Assignees: Abbott Laboratories, Tobishi Yakuhin Kogyo Kabushiki KaishaInventors: David K. Johnson, Steven J. Kline
-
Patent number: 5232915Abstract: 9.alpha.-Hydroxy-19,11.beta.-bridged steroids of general formula I ##STR1## are described. The more detailed meaning of A, B, R.sup.1, R.sup.2, G, Z, R.sup.4 --Y and R.sup.4' --Y' follows from the description. The steroids of general formula I have antigestagen and/or antiglucocorticoidal action and can be used for the production of pharmaceutical agents.Type: GrantFiled: January 14, 1992Date of Patent: August 3, 1993Assignee: Schering AktiengesellschaftInventors: Eckhard Ottow, Gunter Neef, Rudolf Wiechert, Walter Elger, Sybille Beier, Karl-Heinrich Fritzemeier
-
Patent number: 5068326Abstract: Novel CNS dopamine D-1 receptors, such as the compound (.+-.)-8-chloro-2,3,4,5-tetrahydro-3-methyl-5-(4'-[.sup.125 I]iodophenyl)-1H-3-benzazepine-7-ol, are disclosed. These compounds are useful as imaging agents for D-1 receptors in the human brain and exhibit good brain retention and in vivo stability.Type: GrantFiled: April 3, 1989Date of Patent: November 26, 1991Inventor: Hank F. Kung
-
Patent number: 4975536Abstract: The present invention is a process for conversion of .DELTA..sup.16 -steroids (I) ##STR1## to the corresponding .DELTA..sup.17(20) -20-silyl ether (III) ##STR2## by reaction with (1) a preformed copper hydride or a metal hydride reducing agent in the presence of a copper species and (2) a silylating agent. The .DELTA..sup.17(20) -20-silyl ether (III) are useful intermediates in the preparation of steroids useful as pharmaceuticals.Type: GrantFiled: June 2, 1989Date of Patent: December 4, 1990Assignee: The Upjohn CompanyInventor: Kenneth P. Shephard
-
Patent number: 4954414Abstract: A composition including a cationic transition metal coordination complex and a borate anion, wherein said composition is capable of absorbing actinic radiation and producing free radicals which can initiate free radical addition polymerization of a free radical addition polymerizable or crosslinkable monomer is disclosed. The compositions are particularly useful as visible light photoinitiators.Type: GrantFiled: November 8, 1988Date of Patent: September 4, 1990Assignee: The Mead CorporationInventors: Paul C. Adair, Peter Gottschalk
-
Patent number: 4945064Abstract: Estrane and androstane derivatives of formula I ##STR1## wherein X is bromine, iodine, triphenyltin or trialkyltin of 1 to 6 carbon atoms per alkyl radical,Y represents two hydrogen atoms or methylene,Z represents two hydrogen atoms, oxo or alkylenedioxy of 2 to 6 carbon atoms andV is ethylene, vinylene, 1,3-propylene or cyclopropylene,R.sub.1 is hydrogen or a hydrocarbon radical of up to 8 hydrocarbon atoms, optionally interrupted by an oxa group or substituted by an oxo group,R.sub.2 is methyl or ethyl,R.sub.3 and R.sub.4 represent a carbon-carbon bond or R.sub.3 is hydrogen and R.sub.4 is hydrogen or methyl,.DELTA.symbolizes a 4(5)-double bond if Z signifies two hydrogen atoms or an oxo group; or a 5(6)-double bond or, for the estrane derivatives of formula I, also a 5(10)-double bond, if Z is alkylenedioxy,are pharmacologically effective substances or intermediates for preparation thereof.Type: GrantFiled: January 19, 1988Date of Patent: July 31, 1990Assignee: Schering AktiengesellschaftInventors: Helmut Hofmeister, Henry Laurent, Paul E. Schulze, Klaus Annen, Rudolf Wiechert, Kunhard Pollow, Bernhard Manz, Hans-Joerg Grill
-
Patent number: 4879379Abstract: Novel platinum(II)-steroid complexes are now provided, which exhibit antitumor activities as shown by tests on mouse leukemia, L-1210 cells in mice. These novel platinum(II)-steroid complexes contain a 1,2-cyclohexanediamine, a 2-(aminomethyl)cyclohexylamine, an ethylenediamine or NH.sub.3 --groups as a ligand or ligands.Type: GrantFiled: September 17, 1987Date of Patent: November 7, 1989Assignee: Yoshinori KidaniInventors: Yoshinori Kidani, Masahide Noji
-
Patent number: 4874855Abstract: Disclosed are steroid compounds represented by general formula (I) ##STR1## wherein X and W together as >W-X represent a carbonyl group (>C.dbd.O) or a hydroxymethylene group (>CH(OH)), the hydroxy moiety of the hydroxymethylene group being of .beta.-arrangement, and OR.sup.1 and OR.sup.2 independently represent an ester residue, and Y and Z together as --Y--Z-- represent a --(PpSe)CH--CH.sub.2 -- group where Pp represent a phenyl group or a 2-pyridyl group, or Y and Z each represent an ethenylene group or a 1-bromoethylene group.Also disclosed is a process of preparing the compound (I) includes reacting 6.beta., 9.alpha.-difluoro-5.alpha.,17.alpha.,21-trihydroxypregna-3,11,20-trione-17 ,21-diesters or 6.beta.,9.alpha.-difluoro-5.alpha.,11.beta.,17.alpha.Type: GrantFiled: May 3, 1988Date of Patent: October 17, 1989Assignee: Dainippon Ink and Chemicals, Inc.Inventors: Hidetsugu Takagaki, Masayoshi Abe, Michihiro Watanabe, Kazuyuki Takeuchi, Shigenori Nakanishi, Yuuko Nakata, Keiji Yamazaki