The Bicyclo Ring System Is 1,4-benzodiazepine (including Hydrogenated) Patents (Class 540/504)
The chalcogen double bonded directly to the hetero ring is sulfur (Class 540/505)
Additional chalcogen bonded directly to ring carbon of the hetero ring (Class 540/506)
Acyclic nitrogen bonded directly to the hetero ring (Class 540/509)
Having -c(=x)-, wherein x is chalcogen, bonded directly to the hetero ring (Class 540/510)
Halogen bonded directly to the hetero ring (Class 540/511)
Chalcogen attached indirectly to nitrogen of the hetero ring by acyclic nonionic bonding (Class 540/512)
Sulfur, -c(=x)-, wherein x is chalcogen, or nitrogen, other than as nitro or nitroso, bonded directly to the carbocyclic ring of the bicyclo ring system (Class 540/513)
Nitrogen in the 1-position substituent of the bicyclo ring system (Class 540/514)
Preparation by cyclizing benzophenones or imine derivatives thereof (Class 540/515)
Preparation from a compound containing a different hetero ring (Class 540/516)
  • Assay for D-1 antagonistic activity of neuroleptic drugs
    Patent number: 4760029
    Abstract: A method, reagents, and kit for determining the levels of D-1 receptor antagonistic activity of neuroleptic drugs. The method correlates competition between analyte and tritiated R-(+)-8-chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepin-7-ol for binding to D-1 receptors in mammalian brain tissue.
    Type: Grant
    Filed: November 19, 1984
    Date of Patent: July 26, 1988
    Assignee: Schering Corporation
    Inventors: Allen Barnett, William Billard, Louis Iorio
  • Benzodiazinone-pyridazinone and hydroxy-pyrazolyl compounds, cardiotonic compositions including the same, and their uses
    Patent number: 4725686
    Abstract: A method for increasing cardiotonic contractility in humans or other animals using a class of benzodiazinonepryidazinone and hydroxy-pyrazolyl compounds and pharmaceutical compositions including the same.
    Type: Grant
    Filed: November 22, 1985
    Date of Patent: February 16, 1988
    Assignee: William H. Rorer, Inc.
    Inventors: Donald E. Kuhla, Henry F. Campbell, William L. Studt, William C. Faith, Bruce F. Molino
  • Hydroxy and aminothiazolyl-benzodiazinone compounds, cardiotonic compositions including the same, and their uses
    Patent number: 4666913
    Abstract: A method for increasing cardiotonic contractility in humans or other animals using a class of hydroxy and aminothiazolyl-benzodiazinone compounds and pharmaceutical compositions including the same.
    Type: Grant
    Filed: November 22, 1985
    Date of Patent: May 19, 1987
    Assignee: William H. Rorer, Inc.
    Inventors: Donald E. Kubla, Henry F. Campbell, William L. Studt, Bruce F. Molino, Thomas J. Tucker
  • New benzodiazepines and their use
    Patent number: 4647560
    Abstract: The present invention relates to novel benzodiazepines, acid addition salts thereof, processes for their preparation and their use in combating diseases, in particular for the treatment of cerebral disorders caused by old age and for the treatment of disorders in learning and memory and amnesia.
    Type: Grant
    Filed: August 8, 1985
    Date of Patent: March 3, 1987
    Assignee: Troponwerke GMBH & Co. KG
    Inventors: Karl-Heinz Boltze, Eugen Etschenberg, Jorg Traber, Herbert Busgen
  • Fused aromatic oxazepinones, thiazepinones, diazepinones and sulfur analogs thereof
    Patent number: 4642343
    Abstract: Aromatic azepinones and thiones having the formula ##STR1## wherein: A is benzene, naphthalene, quinoline or pyridine;B is oxygen or sulfur;E is oxygen, sulfur or ##STR2## n is 1, 2 or 3; Z is an amino or a heterocyclic nitrogen containing radical;R is hydrogen, loweralkyl, cycloalkyl or phenylloweralkyl;and having antihistaminic utility, a process for the preparation thereof and chemical intermediates therefor are disclosed.
    Type: Grant
    Filed: March 3, 1986
    Date of Patent: February 10, 1987
    Assignee: A. H. Robins Company, Incorporated
    Inventor: Albert D. Cale, Jr.