The Hetero Ring Shares The 11,12-positions Of The Cyclopentanohydrophenanthrene Ring System Patents (Class 540/82)
  • Compounds useful in the manufacture of an anti-inflammatory androstane derivative
    Publication number: 20040220157
    Abstract: The present invention relates to, for example, compounds of formula (VI) 1
    Type: Application
    Filed: June 7, 2004
    Publication date: November 4, 2004
    Inventors: Keith Biggadike, Steven John Coote, Rosalyn Kay Nice
  • Stereoselective process for the production of 6alpha-fluorpregnanes and intermediates
    Publication number: 20040181055
    Abstract: 6&agr;-fluorpregnanes (I), where the dotted line between positions 1 and 2 represents a single or double bond; R1 is OH, OCOR2, X, SO3R3, or an (R7)(R8)(R9)SiO— group, where X is halogen, R2 and R3 are C1-6 alkyl or phenyl optionally substituted by C1-4 alkyl, and R7, R8 and R9, equal or different, are C1-6 alkyl or phenyl optionally substituted by C1-4 alkyl, can be obtained by means of a high stereoselectivity process comprising reacting a 3-(trisubstituted)silyloxy-pregna-3,5-diene (IV) with a fluorinating agent selected among N-fluorosulfonimides and N-fluorosulfonamides. The 6&agr;-fluorpregnanes (I) are intermediates for the synthesis of steroids useful as anti-inflammatory and anti-asthmatic agents.
    Type: Application
    Filed: January 26, 2004
    Publication date: September 16, 2004
    Applicant: Ragactives, S.L.
    Inventors: Jose Vicente Murillo Garrido, Luis Octavio Silva Guisasola, Jorge Martin Juarez
  • Method for the preparation of 6alpha-fluoro corticosteroids
    Publication number: 20030162959
    Abstract: A method for producing a 6&agr;-fluorinated corticosteroid or derivative thereof by reacting a 17-hydroxy-21-ester epoxide of Formula II 1
    Type: Application
    Filed: November 27, 2002
    Publication date: August 28, 2003
    Inventors: Shimon Chernyak, Martin Zarbov, Daniella Gutman