Phenoxazines (including Hydrogenated) Patents (Class 544/102)
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Patent number: 8231690Abstract: The present invention relates to a composition for the coloring of keratin fibres, notably hair, that comprises a phenoxazinone dye of formula (I) as well as the use of this dye for hair coloring. The invention thus makes it possible to obtain coloration that respects the nature of the hair and offers strong shades, which are resistant and have low selectivity.Type: GrantFiled: November 16, 2009Date of Patent: July 31, 2012Assignee: L'OrealInventors: Boris Lalleman, Patrick Choisy, Alain Lagrange
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Publication number: 20120178747Abstract: The mechanism by which the high bone mass (HBM) mutation (G171V) of the Wnt coreceptor LRP5 regulates the canonical Wnt signaling was investigated. The mutation was previously shown to reduce Dkk protein-1-mediated antagonism, suggesting that the first YWTD repeat domain where G171 is located may be responsible for Dkk protein-mediated antagonism. However, we found that the third YWTD repeat, but not the first repeat domain, is required for DKK1-mediated antagonism. Instead, we found that the G171V mutation disrupted the interaction of LRP5 with Mesd, a chaperon protein for LRP5/6 that is required for the coreceptors' transport to cell surfaces, resulting in less LRP5 molecules on the cell surface. Although the reduction in the level of cell surface LRP5 molecules led to a reduction in Wnt signaling in a paracrine paradigm, the mutation did not appear to affect the activity of coexpressed Wnt in an autocrine paradigm.Type: ApplicationFiled: November 14, 2006Publication date: July 12, 2012Inventors: Dianqing (Dan) Wu, Dakai Liu, James J. Donegan
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Publication number: 20120175599Abstract: [Problem] An organic compound of excellent characteristics is provided that exhibits excellent hole-injecting/transporting performance with electron blocking ability, and that has high stability in the thin-film state and high luminous efficiency, the organic compound being provided as material for an organic electroluminescent device having high efficiency and high durability. The invention also provides a high-efficient, high-durable organic electroluminescent device using the compound. [Means for Resolution] The compound is of the following general formula having a carbazole ring structure. The organic electroluminescent device includes a pair of electrodes, and one or more organic layers sandwiched between the pair of electrodes, and the compound is used as a constituent material of at least one organic layer.Type: ApplicationFiled: August 25, 2010Publication date: July 12, 2012Applicant: Hodogaya Chemical Co., Ltd.Inventors: Norimasa Yokoyama, Makoto Nagaoka, Kazunori Togashi, Shigeru Kusano
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Publication number: 20120149697Abstract: The present invention relates to the medical field, in particular to the use of natural organic polyanions, i.e. humic substances, HSs, in the treatment of neurodegenerative diseases, such as Prion disease, Alzheimer's and Parkinson's disease.Type: ApplicationFiled: July 13, 2010Publication date: June 14, 2012Applicant: SCUOLA INTERNAZIONALE SUPERIORE DI STUDI AVANZATIInventors: Giuseppe Antonio Legname, Liviana Leita, Paolo Sequi
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Publication number: 20120135532Abstract: The present invention relates to a sensor comprising a resorufin compound having sulfite ion selectivity and a method for detecting sulfite ions using the same. More specifically, the resorufin compound may have outstandingly increased fluorescence intensity by a deprotection reaction that a levulinyl group is cleaved with a sulfite ion to be used as a selective fluorescence sensor of turn-on type, and also represent a chromogenic change to detect sulfite ions by naked eye.Type: ApplicationFiled: October 26, 2011Publication date: May 31, 2012Applicant: Chung-Ang University Industry-Academiy Cooperation FoundationInventors: Suk-Kyu CHANG, Myung Gil CHOI, Suyoung EOR, Jiyoung HWANG
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Publication number: 20120129159Abstract: The present disclosure provides compositions and methods of use thereof for labeling peptide and proteins in vitro or in vivo. The methods described herein employ lipoic acid ligase or mutants thereof, and lipoic acid analogs (e.g., lipoic acid analogs comprising a resorufin moiety) recognized by lipoic acid ligase and lipoic acid ligase mutants. Also provided herein is a method of imaging protein-protein interaction via a reaction mediated by lipoic acid ligase.Type: ApplicationFiled: October 6, 2011Publication date: May 24, 2012Inventors: Alice Y. Ting, David Baker, Florian Richter, Lucas Nivon, Daniel Shao-Chen Liu
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Publication number: 20120116079Abstract: Reagents are provided for the introduction of phosphonate groups into fluorescent dyes. Methods are also provided for preparing dye conjugates.Type: ApplicationFiled: August 29, 2011Publication date: May 10, 2012Inventors: Eugeny Lukhtanov, Alexei Vorobiev
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Publication number: 20120080585Abstract: To provide a photoelectric conversion element capable of functioning as a photoelectric conversion element when a compound having a specific structure is applied to the photoelectric conversion element, causing the element to exhibit a low dark current, and reducing the range of increase in the dark current even when the element is heat-treated, and an imaging device equipped with such a photoelectric conversion element. A photoelectric conversion element having a photoelectric conversion film which is sandwiched between a transparent electrically conductive film and an electrically conductive film and contains a photoelectric conversion layer and an electron blocking layer, wherein the electron blocking layer contains a compound having, as a substituent, a substituted amino group containing three or more ring structures.Type: ApplicationFiled: June 3, 2010Publication date: April 5, 2012Applicant: FUJIFILM CORPORATIONInventors: Eiji Fukuzaki, Kimiatsu Nomura
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Publication number: 20120053315Abstract: A monomer of formula (III): wherein X is a polymerisable group Ar, Ar1 and Ar2 each independently represent an optionally substituted aryl or heteroaryl group; R1 represents H or a substituent; and Z represents a direct bond or a divalent linking atom or group, wherein Ar1 and Ar2 are linked by a single bond or a divalent linking group selected from CR1R2, SiR1R2, PR1, NR1, O and S wherein R1 and R2 are independently selected from hydrogen; optionally substituted alkyl wherein one or more non-adjacent C atoms may be replaced with O, S, N, C?O and —COO—; alkoxy, aryl, arylalkyl, heteroaryl and heteroarylalkyl. Ar1 and Ar2 are preferably linked by an oxygen atom, and Ar1 and/or Ar2 may be fused to their respective adjacent Ar groups. Ar1 and its adjacent Ar group and/or Ar2 and its adjacent Ar group are optionally fused to form a fluorene unit.Type: ApplicationFiled: April 15, 2010Publication date: March 1, 2012Applicants: Sumitomo Chemical Company Limited, Cambridge Display Technology LimitedInventors: Mary McKiernan, Thomas Pounds
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Patent number: 8114904Abstract: Provided herein are compounds or fluorogenic probes which can be used as reagents for measuring, detecting and/or screening ROS or RNS such as peroxynitrite or hypochlorite. Provided also herein are methods that can be used to measure, directly or indirectly, the amount of peroxynitrite or hypochlorite in chemical samples and biological samples such as cells and tissues in living organisms. Specifically, the methods include the steps of contacting the fluorogenic probes disclosed herein with the samples to form one or more fluorescent compounds, and measuring fluorescence properties of the fluorescent compounds. Provided also herein are high-throughput screening fluorescent methods for detecting or screening peroxynitrite or compounds that can increase or decrease the level of peroxynitrite or hypochlorite in chemical and biological samples.Type: GrantFiled: April 3, 2009Date of Patent: February 14, 2012Assignee: Versitech Limited & Morningside Ventures LimitedInventors: Dan Yang, Tao Peng
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Publication number: 20120035359Abstract: The present invention encompasses phenoxazine derivatives and methods of use thereof.Type: ApplicationFiled: August 1, 2011Publication date: February 9, 2012Applicant: THE WASHINGTON UNIVERSITYInventors: Gregory Zipfel, Byung Han, Robert Mach, Wenhau Chu
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Publication number: 20120013246Abstract: A dendrimer and an organic light-emitting device including an organic layer having the dendrimer.Type: ApplicationFiled: July 8, 2011Publication date: January 19, 2012Applicant: Samsung Mobile Display Co., Ltd.Inventors: Yoon-Hyun KWAK, Jeoung-In Yi, Seung-Gak Yang, Hee-Yeon Kim, Jae-Yong Lee
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Publication number: 20120009683Abstract: The present invention provides fluorogenic compounds for the detection of target metal ions wherein the compounds exhibit a Stokes shift greater than 50 nm and the detectable signal is modulated by photoinduced electron transfer (PET). The present compounds consist of three functional elements, the ion sensing moiety (chelating moiety), the reporter moiety (fluorophore or fluorescent protein) and spacer or linker between the sensing and reporter moieties of the present compound that allows for PET upon binding of a metal ion and excitation by an appropriate wavelength.Type: ApplicationFiled: July 29, 2011Publication date: January 12, 2012Applicant: LIFE TECHNOLOGIES CORPORATIONInventors: Kyle Richard GEE, Vladimir MARTIN
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MATERIAL FOR PHOSPHORESCENT LIGHT-EMITTING ELEMENT AND ORGANIC ELECTROLUMINESCENT ELEMENT USING SAME
Publication number: 20120001165Abstract: Provided is an organic electroluminescent device (organic EL device), which has improved luminous efficiency, has sufficient driving stability, and has a simple construction. The organic EL device of the present invention is an organic electroluminescent device, including a light-emitting layer and a hole-transporting layer between an anode and a cathode laminated on a substrate, in which the light-emitting layer contains a phosphorescent light-emitting dopant and an indolocarbazole compound that serves as a host material, or alternatively, the hole-transporting layer contains an indolocarbazole compound. The indolocarbazole compound is represented by the following formula (1). In the formula: A1's each represent an aromatic hydrocarbon group or an aromatic heterocyclic group, provided that at least one of A1's has a fused ring structure; and R1's each represent a hydrogen atom, an alkyl group, an alkoxy group, or an acyl group.Type: ApplicationFiled: March 25, 2010Publication date: January 5, 2012Inventors: Masaki Komori, Takahiro Kai, Toshihiro Yamamoto -
Publication number: 20110309341Abstract: A polymer compound comprising a constituent unit represented by the following formula (1a): wherein ring A and ring B represent an aromatic hydrocarbon ring. R1 is a group represented by the following formula (2). R2 represents an aryl group or a monovalent aromatic heterocyclic group. wherein Ar1 represents an arylene group or a divalent group comprising two or more directly bonded arylene groups; Ar4 and Ar5 represent an aryl group or a monovalent aromatic heterocyclic group; Ar2 and Ar3 represent an arylene group or a divalent aromatic heterocyclic group; R6 represents a hydrogen atom, an alkyl group, an aryl group or a monovalent aromatic heterocyclic group.Type: ApplicationFiled: November 18, 2009Publication date: December 22, 2011Applicants: SUMATION CO., LTD., SUMITOMO CHEMICAL COMPANY, LIMITEDInventors: Kazuei Ohuchi, Tomoya Nakatani
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Publication number: 20110313155Abstract: A method of forming a 3-phenylimino-3H-phenothiazine or a 3-phenylimino-3H-phenoxazine mediator includes providing a first reactant including phenothiazine or phenoxazine, providing a first solvent, providing a second reactant and providing a second solvent. The first reactant, first solvent, second reactant and second solvent are combined to form a reactants solution. Sodium persulfate is added to the reactants solution to couple the first and second reactants resulting in a reaction solution including the 3-phenylimino-3H-phenothiazine or the 3-phenylimino-3H-phenoxazine mediator.Type: ApplicationFiled: August 11, 2011Publication date: December 22, 2011Applicant: BAYER HEALTHCARE LLCInventors: Karen L. Marfurt, Henry C. Arndt
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Publication number: 20110226610Abstract: Inventors have developed a chromophore (nitrodibenzylfuranyl, or NBDF) for ultra efficient uncaging of a caged substrate (e.g., an organic molecule such as, for example, an amino acid, a biological molecules, such as, for example, second messengers inside cells). Photolysis of a NBDF derivative of EGTA (i.e. caged calcium) is about 50 times more efficient than others calcium cages (the quantum yield of photolysis is 0.6 and the extinction coefficient is 18,400. NDBF-EGTA has a 2-photon cross section of about 0.3-0.6 GM).Type: ApplicationFiled: February 18, 2011Publication date: September 22, 2011Applicant: Philadelphia Health & Education Corporation d/b/a Drexel University College of MedicineInventors: Graham Ellis-Davies, Atsuya Momotake
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Publication number: 20110196147Abstract: This invention relates to compounds for the inhibition of histone deacetylase. More particularly, the invention provides for compounds of formula (I) wherein Q, J, L and Z are as defined in the specification.Type: ApplicationFiled: April 4, 2011Publication date: August 11, 2011Inventors: Robert Déziel, Silvana Leit, Patrick Beaulieu, Yves Andre Chantigny, John Mancuso, Pierre Tessier, Gideon Shapiro, Richard Chesworth, David Smil
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Publication number: 20110178001Abstract: The present invention relates to phosphonated Rifamycins, and methods of making and using such compounds. These compounds are useful as antibiotics for prophylaxis and/or the treatment of bone and joint infections, especially for the prophylaxis and/or treatment of osteomyelitis.Type: ApplicationFiled: August 10, 2009Publication date: July 21, 2011Applicant: TARGANTA THERAPEUTICS CORP.Inventors: Evelyne Dietrich, Ranga Reddy, Kelly Tanaka, Ting Kang, Yanick Lafontaine, Adel Rafai Far
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Publication number: 20110108820Abstract: A polymer compound comprising a residue of a compound represented by the following formula (0): wherein Ar0 represents a substituent such as a hydrogen atom, an alkyl group, an alkoxy group, an aryl group and the like, or a group represented by the following formula (A), at least two Ar0s are groups represented by the following formula (A), R0 represents a substituent such as an alkyl group, an alkoxy group, an aryl group and the like, l and m represent an integer of 0 to 3, wherein A0 represents —N? or —C(R2)?. R2 represents a substituent such as a hydrogen atom, an alkyl group, an alkoxy group, an aryl group and the like.Type: ApplicationFiled: June 26, 2009Publication date: May 12, 2011Inventor: Satoshi Kobayashi
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Patent number: 7932050Abstract: Enzymatic phenoxazinone substrates of formula (I): in reaction media containing the same are used for detecting, identifying and/or quantifying microorganisms expressing at least one peptidase activity.Type: GrantFiled: September 22, 2009Date of Patent: April 26, 2011Assignee: bioMerieuxInventors: Rosaleen Joy Anderson, Paul William Groundwater, Arthur James, Daniel Monget, Andrey Victorovich Zaytsev
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Publication number: 20110086341Abstract: The invention provides novel fluorinated resorufin compounds that are of use in a variety of assay formats. Also provided are methods of using the compounds and kits that include a compound of the invention and instructions detailing the use of the compound in one or more assay formats.Type: ApplicationFiled: December 17, 2010Publication date: April 14, 2011Applicant: LIFE TECHNOLOGIES CORPORATIONInventors: Robert Batchelor, Yue Ge, Iain Johnson, Wai-Yee Leung, Jixiang Liu, Brian Patch, Peter Smalley, Thomas Steinberg, Kyle Gee
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Publication number: 20110061723Abstract: The present invention pertains to an electrode layer comprising a porous film made of oxide semiconductor fine particles sensitized with certain methin dyes. Moreover the present invention pertains to a photoelectric conversion device comprising said electrode layer, a dye sensitized solar cell comprising said photoelectric conversion device and to novel methin dyes.Type: ApplicationFiled: February 26, 2009Publication date: March 17, 2011Applicant: BASF SEInventors: Kazuhiko Kunimoto, Hiroshi Yamamoto, Shinji Nakamichi, Ryuichi Takahashi, Junichi Tanabe
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Patent number: 7879995Abstract: An organic electroluminescent device, which has, between a pair of electrodes, at least one organic layer including a light-emitting layer, in which the organic layer contains a specific tetraphenylene compound, and in which the light-emitting layer contains a phosphorescent material; and a specific tetraphenylene compound that can be used in the device.Type: GrantFiled: November 20, 2008Date of Patent: February 1, 2011Assignee: Fujfilm CorporationInventors: Jun Ogasawara, Tatsuya Igarashi, Satoshi Sano
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Patent number: 7875712Abstract: This invention provides caspase inhibitors of formula I: wherein Z is oxygen or sulfur; R1 is hydrogen, —CHN2, R, CH2OR, CH2SR, or —CH2Y; ?between R3 and R4 represents a single or double bond; Y is an electronegative leaving group; R2 is CO2H, CH2CO2H, or esters, amides or isosteres thereof; R3 is a group capable of fitting into the S2 subsite of a caspase enzyme; R4 is a hydrogen or C1-6 alkyl or R3 and R4 taken together form a ring; Ring A and Ring B are each heterocyclic rings, and R and R5 are as described in the specification. The compounds are effective inhibitors of apoptosis and IL-1? secretion.Type: GrantFiled: September 23, 2008Date of Patent: January 25, 2011Assignee: Vertex Pharmaceuticals IncorporatedInventors: Michael Mortimore, Andrew Miller, John Studley, Jean-Damien Charrier
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Patent number: 7875367Abstract: A cyclopentaphenanthrene-based compound is easy to prepare and excellent in solubility, color purity, and color stability. The cyclopentaphenanthrene-based compound is useful as a material for forming an organic layer, in particular, an emitting layer, in an organoelectroluminescent device, and as an organic dye or an electronic material such as a nonlinear optical material.Type: GrantFiled: July 18, 2007Date of Patent: January 25, 2011Assignee: Samsung Mobile Display Co., Ltd.Inventors: Sang-Hoon Park, Yu-Jin Kim, Jhun-Mo Son, Byoung-Ki Choi, O-Hyun Kwon, Myeong-Suk Kim
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Publication number: 20110015137Abstract: The present invention provides RecA inhibitors, compositions containing them, systems for identifying or characterizing them, and methods of using them.Type: ApplicationFiled: July 7, 2008Publication date: January 20, 2011Applicant: Trustees of Boston UniversityInventor: Guillaume Cottarel
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Publication number: 20100324285Abstract: An object of the present invention is to provide anti-inflammatory agent having an excellent effect and less adverse side-effects. The object is attained by providing an anti-inflammatory agent comprising 2-aminophenol or a derivative thereof as an effective ingredient.Type: ApplicationFiled: October 15, 2007Publication date: December 23, 2010Inventors: Masaki Miyake, Keizo Kohno, Osamu Sano
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Publication number: 20100298200Abstract: The present invention relates to the field of therapeutic methods to screen for compounds on the basis of their ability to influence Wnt activity. The screening process is applied to both a physical library of a series of compounds and a virtual library of compounds that affect Wnt activity. In one aspect, the virtual screening process could be carried out where a permutational library of small peptides is substituted for the small organic molecules. The inventive methods may be used to empirically test for effects on Wnt activity and may also be applied to any pair of proteins involved in protein-protein interactions.Type: ApplicationFiled: May 22, 2009Publication date: November 25, 2010Inventors: Dakai Liu, Xiaofeng Li, Richard Jin, Yuaxin Liang, Wei Cheng, Riddhi Bhattacharyya, Guangrong Zhang
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Publication number: 20100298308Abstract: The mechanism by which the high bone mass (HBM) mutation (G171V) of the Wnt coreceptor LRP5 regulates the canonical Wnt signaling was investigated. The mutation was previously shown to reduce Dkk protein-1-mediated antagonism, suggesting that the first YWTD repeat domain where G171 is located may be responsible for Dkk protein-mediated antagonism. However, we found that the third YWTD repeat, but not the first repeat domain, is required for DKK1-mediated antagonism. Instead, we found that the G171V mutation disrupted the interaction of LRP5 with Mesd, a chaperon protein for LRP5/6 that is required for the coreceptors' transport to cell surfaces, resulting in less LRP5 molecules on the cell surface. Although the reduction in the level of cell surface LRP5 molecules led to a reduction in Wnt signaling in a paracrine paradigm, the mutation did not appear to affect the activity of coexpressed Wnt in an autocrine paradigm.Type: ApplicationFiled: November 14, 2006Publication date: November 25, 2010Inventors: Dianqing (Dan) Wu, Dakai Liu, James J. Donegan
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Patent number: 7833635Abstract: A cyclopentaphenanthrene-based compound is easy to prepare and excellent in solubility, color purity, color stability, and thermal stability. The cyclopentaphenanthrene-based compound is useful as a material for forming an organic layer, in particular, an emitting layer, in an organoelectroluminescent device, and as an organic dye or an electronic material such as a nonlinear optical material.Type: GrantFiled: July 18, 2007Date of Patent: November 16, 2010Assignee: Samsung Mobile Display Co., Ltd.Inventors: Sang-Hoon Park, Yu-Jin Kim, O-Hyun Kwon, Byoung-Ki Choi, Jhun-Mo Son
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Publication number: 20100286134Abstract: This invention relates to novel phenoxazin-3-one derivatives useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.Type: ApplicationFiled: September 8, 2008Publication date: November 11, 2010Applicant: NeuroSearch A/SInventors: Dan Peters, John Paul Redrobe, Elsebet Østergaard Nielsen
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Patent number: 7794858Abstract: Provided are a phenylphenoxazine- or phenylphenothiazine-based compound and an organic electroluminescent device using the same. The phenylphenoxazine- or phenylphenothiazine-based compound is easily prepared, easily dissolved, and has excellent hole injection properties and excellent thermal stability. Accordingly, the compound is suitable for an organic layer of the organic electroluminescent device, specifically, a hole injection layer or a hole transport layer. In addition, the compound is suitable for an organic pigment or an electronic material, such as a nonlinear optical material.Type: GrantFiled: March 6, 2008Date of Patent: September 14, 2010Assignees: Samsung Electronics Co., Ltd., Samsung Mobile Display Co., Ltd.Inventors: Sang-hoon Park, O-hyun Kwon, Woon-jung Paek
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Publication number: 20100137296Abstract: Compounds that can be used as openers or blockers of voltage-dependent potassium channels, and which are useful in the treatment of conditions such as central or peripheral nervous system disorders through the modulation of potassium ion flux through voltage-dependent potassium channels and/or depressing or enhancing cortical and/or peripheral neuron activity, compositions containing same and methods utilizing same are disclosed. Also disclosed are modulators of voltage-dependent potassium channels, which exhibit blocking of a TRPV1 channel, and hence are useful in the treatment of TRPV1-related conditions.Type: ApplicationFiled: September 18, 2008Publication date: June 3, 2010Applicant: Ramot At Tel Aviv University Ltd.Inventors: Bernard Attali, Asher Peretz
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Publication number: 20100105095Abstract: The invention provides a compound, useful as an optical probe or sensor of the activity of at least one cytochrome P450 enzyme, and methods of using the compound to screen candidate drugs, and candidate drugs identified by these methods.Type: ApplicationFiled: July 7, 2009Publication date: April 29, 2010Applicant: LIFE TECHNOLOGIES CORPORATIONInventors: Lewis R. Makings, Gregor Zlokarnik
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Publication number: 20100093709Abstract: The invention is directed to delta opioid receptor modulators. More specifically, the invention relates to tricyclic ?-opioid modulators. Pharmaceutical and veterinary compositions and methods of treating mild to severe pain and various diseases using compounds of the invention are also described.Type: ApplicationFiled: November 20, 2009Publication date: April 15, 2010Inventors: Steven J. Coats, Scott L. Dax, Bart DeCorte, Li Liu, Mark McDonnell, James J. McNally
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Patent number: 7695930Abstract: The present invention relates to methods for the detection, identification and/or quantification of microorganisms with peptidase activity using enzymatic substrates with the following general formula:Type: GrantFiled: July 22, 2008Date of Patent: April 13, 2010Assignee: BiomerieuxInventors: Arthur James, John Perry, Annette Rigby, Stephen Stanforth
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Publication number: 20100051106Abstract: Provided are novel organic electroluminescent compounds characterized in that they are represented by Chemical Formula (1): wherein, ring A and ring B independently represent a saturated 5- or 6-membered heterocyclic amino group, or a substituent selected from the following structures: wherein the saturated 5- or 6-membered heterocyclic amino group may further comprise one or more heteroatom(s) selected from NR36, O and S; and a and b independently represent an integer from 0 to 4, provided that (a+b) is an integer from 1 to 4.Type: ApplicationFiled: June 23, 2009Publication date: March 4, 2010Applicant: Gracel Display Inc.Inventors: Chi Sik Kim, Young Jun Cho, Hyuck Joo Kwon, Bong Ok Kim, Sung Min Kim, Seung Soo Yoon
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Publication number: 20100022523Abstract: The present invention relates to a novel 3-aminobenzamide compound represented by the following formula which effectively inhibits vanilloid receptor subtype 1 (VR1) activity (wherein, for example, R1 is a C1-6 alkyl group which may be substituted, R2 is a hydrogen atom, a C1-6 alkyl group or a C1-6 alkoxy group which may be substituted, R3 is a hydrogen atom or a C1-6 alkyl group, R4 is a C1-6 alkyl group, a C1-6 alkoxy group, or a halo C1-6 alkyl group, m is an integer of 1 to 5 and P is a carbon or hetero ring) or a pharmaceutically acceptable salt thereof. The pharmaceutical composition comprising as active ingredients the 3-aminobenzamide compound or a pharmaceutically acceptable salt thereof is useful for treating diseases involved in VR1 activity such as pain, acute pain, chronic pain, neuropathic pain, rheumatoid arthritis pain, and neuralgia.Type: ApplicationFiled: April 27, 2009Publication date: January 28, 2010Applicant: Japan Tobacco Inc.Inventors: YOSHIHISA KOGA, SHINJI YATA, TAKASHI WATANABE, TAKUYA MATSUO, MASAHIRO SAKATA, WATARU KONDO
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Publication number: 20100012931Abstract: Provided are a polycyclic compound of a compound having such a structure that two benzene rings bond to a central benzene ring each other to form a fused ring and another fused ring bonds to a terminal thereof, and an organic electroluminescence device including one or more organic thin film layers containing a light emitting layer between a cathode and an anode, in which at least one of the organic thin film layers includes the polycyclic compound of the present invention. The organic electroluminescence device has high luminous efficiency, no defect in pixels, and long lifetime. In addition, provided is a polycyclic compound realizing the organic electroluminescence device.Type: ApplicationFiled: September 2, 2009Publication date: January 21, 2010Applicant: IDEMITSU KOSAN CO., LTD.Inventors: Tomoki KATO, Masaki Numata, Kazuki Nishimura, Toshihiro Iwakuma, Chishio Hosokawa, Kei Yoshida
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Patent number: 7648777Abstract: An organic electroluminescent compound and an organic electroluminescent device using the same. The organic electroluminescent compound having Formula 1 can be used as blue electroluminescent compound. The organic electroluminescent device using the organic electroluminescent compound having Formula 1 has improved luminous efficiency and color purity.Type: GrantFiled: January 23, 2006Date of Patent: January 19, 2010Assignee: Samsung Mobile Display Co., Ltd.Inventors: Sang-Hoon Park, Tae-Yong Noh, O-Hyun Kwon, Sang-Yeol Kim, Jhun-Mo Son, Sung-Hun Lee
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Publication number: 20100000032Abstract: The present invention concerns highly water-soluble phenoxazines dyes of formula (I) wherein R1, R2, R3, R4, R5 and R6 have the meaning defined in the claim, with improved photochemical properties, low toxicity, and favourable solubility in water. It also concerns a method for their preparation.Type: ApplicationFiled: July 7, 2009Publication date: January 7, 2010Applicants: Wetlands Incubator sprl, Setas Kimya San ASInventors: Frederic Bruyneel, Riccardo Basosi, Christian-Marie Bols, Estelle Enaud, Christoph Hercher, Jutta Ismene Jager, Anna Jarosz-Wilkolazka, Jacqueline Marchand-Brynaert, Rebecca Pogni, Jolanta Polak, Sophie Vanhulle
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Patent number: 7626018Abstract: Novel enzymatic substrates of the general formula below: reaction media containing the same and their use for detecting and/or identifying and/or quantifying microorganisms expressing at least one peptidase activity.Type: GrantFiled: September 9, 2005Date of Patent: December 1, 2009Assignee: bioMérieuxInventors: Rosaleen Joy Anderson, Paul William Groundwater, Arthur James, Daniel Monget, Andrey Victorovich Zaytsev
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Publication number: 20090253118Abstract: Provided herein are compounds or fluorogenic probes which can be used as reagents for measuring, detecting and/or screening ROS or RNS such as peroxynitrite or hypochlorite. Provided also herein are methods that can be used to measure, directly or indirectly, the amount of peroxynitrite or hypochlorite in chemical samples and biological samples such as cells and tissues in living organisms. Specifically, the methods include the steps of contacting the fluorogenic probes disclosed herein with the samples to form one or more fluorescent compounds, and measuring fluorescence properties of the fluorescent compounds. Provided also herein are high-throughput screening fluorescent methods for detecting or screening peroxynitrite or compounds that can increase or decrease the level of peroxynitrite or hypochlorite in chemical and biological samples.Type: ApplicationFiled: April 3, 2009Publication date: October 8, 2009Applicants: Versitech Limited, Morningside Ventures LimitedInventors: Dan YANG, Tao PENG
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Publication number: 20090229059Abstract: Disclosed are oxazine disulfide dyes of formula (1) D1-(Z1)r-Y1—S-A, wherein A is hydrogen; or a radical of formula (1a)*—S—Y2-(Z2)r-D2; Y1 and Y2 independently from each other are unsubstituted or substituted, straight-chain or branched, interrupted or uninterrupted C—1—C—10alkylene; C5-C10cycloalkylene; C5-C10arylene; or —C5-C10arylene-(C1-C10alkylene); Z1 and Z2 independently from each other are *—(CH2)p—C(O)—**; *—(CH2CH2—O)S—**; *—(CH2)p—C(O)O—**; *—(CH2)p—OCO—**; *—(CH2)P—N(R1)—**; formula 1(g); —(CH2)p—CON(R1)—**; *—(CH2)p—(R1)NC(O)—**; , 0-; —S—; —S(O)—; —S(O)2—; or a cationic biradical of a substituted or unsubstituted aromatic or heteroaromatic compound of the formula (1a); (1b); (1c); (1d); or (1e); wherein the asterix * indicates the linkage to D1 and/or D2; the asterix ** indicates the linkage to Y1 and/or Y2; W1 is N or a radical of CR5; R1, R2, R3, R4 and R5 independently from each other are hydrogen; C1-C14alkyl; C2-C14alkenyl; C5-C10aryl; C5-C10aryl-(C1-C10alkyl); or —C1-C10alkyl(C5-C10aryl);Type: ApplicationFiled: September 27, 2006Publication date: September 17, 2009Inventors: Christian Cremer, Olof Wallquist
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Publication number: 20090215736Abstract: This invention provides caspase inhibitors of formula I: wherein Z is oxygen or sulfur; R1 is hydrogen, —CHN2, R, CH2OR, CH2SR, or —CH2Y; between R3 and R4 represents a single or double bond; Y is an electronegative leaving group; R2 is CO2H, CH2CO2H, or esters, amides or isosteres thereof; R3 is a group capable of fitting into the S2 subsite of a caspase enzyme; R4 is a hydrogen or C1-6 alkyl or R3 and R4 taken together form a ring; Ring A and Ring B are each heterocyclic rings, and R and R5 are as described in the specification. The compounds are effective inhibitors of apoptosis and IL-1? secretion.Type: ApplicationFiled: September 23, 2008Publication date: August 27, 2009Applicant: Vertex Pharmaceuticals, IncorporatedInventors: Michael Mortimore, Andrew Miller, John Studley, Jean-Damien Charrier
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Publication number: 20090167166Abstract: The present invention relates to compounds according to formula (1) and/or according to formulae (4) to (10) and their use in organic electroluminescent devices, in particular as a matrix material in phosphorescent devices.Type: ApplicationFiled: May 21, 2007Publication date: July 2, 2009Applicant: MERCK PATENT GMBHInventors: Ingrid Bach, Arne Buesing, Susanne Heun, Philipp Stoessel, Michael Holbach, Jonas Kroeber, Amir Hossain Parham
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Publication number: 20090171081Abstract: A method of forming a 3-phenylimino-3H-phenothiazine or a 3-phenylimino-3H-phenoxazine mediator includes providing a first reactant including phenothiazine or phenoxazine, providing a first solvent, providing a second reactant and providing a second solvent. The first reactant, first solvent, second reactant and second solvent are combined to form a reactants solution. Sodium persulfate is added to the reactants solution to couple the first and second reactants resulting in a reaction solution including the 3-phenylimino-3H-phenothiazine or the 3-phenylimino-3H-phenoxazine mediator.Type: ApplicationFiled: December 9, 2008Publication date: July 2, 2009Inventors: Karen L. Marfurt, Henry C. Arndt
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Publication number: 20090117040Abstract: The present invention relates to pharmaceutical and diagnostic compositions as well as to the use of the active substances contained therein for preparing a pharmaceutical or a diagnostic composition for the treatment or diagnosis of neurodegenerative disorders or amyloid diseases.Type: ApplicationFiled: February 11, 2005Publication date: May 7, 2009Applicant: Max-Delbrug-Centrum Fur Molekulare MedizinInventors: Erich Wanker, Sabine Engemann, Susanne Rautenberg, Annett Boeddrich, Phoebe Markovic, Dagmar Ehrnhofer, Martin Herbst, Jacqueline Walther
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Publication number: 20090104711Abstract: Disclosed herein are fluorescent markers having a double bond ester group and a method for marking and detecting the same. More particularly, disclosed are a method for identifying oil products, which comprises marking the oil products with fluorescent markers having an unsaturated double bond ester group, adding a developing agent having a function of inducing specific fluorescence to the marked oil products, and detecting the fluorescent marker with a fluorescence spectrophotometer in the UV/VIS region, as well as said markers.Type: ApplicationFiled: July 28, 2006Publication date: April 23, 2009Inventor: Hyun-Ho Sim