Abstract: This disclosure describes novel substituted .omega.-heteroaroyl(propionyl or butyryl)-L-prolines and the esters and cationic salts thereof which are useful as hypotensive agents in mammals.

Abstract: Compounds of the steroisomeric formulas ##STR1## wherein R.sub.1 and R.sub.2, which may be identical to or different from each other, are each phenyl, substituted phenyl, thienyl or furyl;R.sub.3 is hydrogen or straight or branched alkyl of 1 to 3 carbon atoms; andR.sub.4 is straight or branched alkyl of 1 to 3 carbon atoms; orR.sub.3 and R.sub.4, together with each other and the nitrogen atom to which they are attached, form a piperidino, 4-amino-piperidino, 4-(lower alkylamino)-piperidino, piperazino, 4-(alkyl of 1 to 2 carbon atoms)-piperazino or morpholino radical; and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as antidepressants.

Abstract: Novel 2-Benzothiepins, having substituents in the 1-position heretofore unknown, are described. The compounds possess hypotensive and antipsychotic properties; methods and compositions using them are described.

Abstract: 2,3-Dihydro-1-benzothiepin-4-carboxamides, e.g. those of the formula ##STR1## Am=NH.sub.2, mono- or di-(alkyl or HO-alkyl)-amino, alkyleneimino, cycloalkylamino, iso- or heterocyclic arylamino or N-alkyl-N-arylaminoX=HO, alkoxy, alkanoyloxy or tert.AmR=H, alkyl, alkoxy, alkylmercapto, halo, CF.sub.3, CN or NO.sub.2n=O-2or their salts with therapeutically useful bases, exhibit anti-inflammatory effects.

Abstract: 1,3-Benzodithiole-2-thione compounds are disclosed including the novel method of preparing said compounds and their biocidal activity.

Abstract: 2,3-Dihydro-1-benzothiepin-4-carboxamides, e.g. those of the formula ##STR1## Am=arylamino or N-alkyl-N-arylamino substituted by R X=HO, alkoxy, alkanoyloxy or alkyleneiminoR=alkyl, alkoxy, alkylmercapto, halo, CF.sub.3, CN, or NO.sub.2n=0-2or their salts with therapeutically useful bases, exhibit anti-inflammatory effects.

Abstract: 1,3-Benzodithiole-2-one and 1,3-benzodithiole-2-thione compounds are disclosed including the novel method of preparing said compounds and their biocidal activity.

Abstract: 1,3-Benzodithiole-2-one and 1,3-benzodithiole-2-thione compounds are disclosed including the novel method of preparing said compounds and their biocidal activity.

Abstract: 2,3-Dihydro-1-benzothiepin-4-carboxamides, e.g. those of the formula ##STR1## Am=NH.sub.2, mono- or di-(alkyl or HO-alkyl)-amino, alkyleneimino, cycloalkylamino, iso- or heterocyclic arylamino or N-alkyl-N-arylaminoX=ho, alkoxy, alkanoyloxy or tert. AmR=h, alkyl, alkoxy, alkylmercapto, halo, CF.sub.3, CN or NO.sub.2n=0-2Or their salts with therapeutically useful bases, exhibit anti-inflammatory effects.

Abstract: 1-Alkoxyethanol-isochromas, -isothiochromas, -2-benzoxepins, and -2-benzothiepins are described. These compounds are useful for preparing the corresponding aminoalkoxyalkyl derivatives that possess antihypertensive and CNS activity.

Abstract: Heterocyclylcarbonyl derivatives of urea having the formula ##STR1## wherein R is a heterocyclyl group; R.sub.1 is hydrogen, alkyl having up to ten carbon atoms or phenyl; R.sub.2 is R.sub.1, 1-naphthyl and phenylalkyl having 1 to 4 carbon atoms in the alkyl group; and R.sub.1 and R.sub.2 when taken together with the nitrogen to which they are attached are morpholino, thiomorpholino or a 6-8 membered nitrogen containing heterocyclic ring; methods for their preparation and use as agents for dissolving gallstones.

Abstract: 4,5-Dichloro-3-substituted-phenylimino-1,2-dithiolenes of the formula ##STR1## in which R is optionally chlorine-substituted or methoxy-substituted phenyl which carries at least one substituent selected independently from fluorine, bromine, iodine, cyano, thiocyanato, nitro, alkyl, cycloalkyl, halogenoalkyl, aryl, alkoxy with 2-6 carbon atoms, aryloxy, alkylthio, arylthio, acylamino, dialkylamino, alkoxycarbonyl, alkycarbonyl, aminocarbonyl, alkysulphonyl, alkoxysulphonyl, aryloxysulphonyl, aminosulphonyl and N-containing heterocyclic rings, or represents phenyl which is monosubstituted, disubstituted or trisubstituted by chlorine in the 2-, 3-, 2,3-, 2,6-, 3,5-, 2,5-, 3,4,5-, 2,4,6- or 2,4,5-positions, andM is 1 or 2, which possess arthropodicidal, nematicidal and fungicidal properties.

Abstract: Heterocyclic oxime compounds are useful as intermediates in the preparation of pesticidally active carbamoyloxime compounds.

Abstract: The invention discloses novel compounds of the general formula: ##STR1## and salts thereof, in which X stands for oxygen, sulphur, the group >NR.sub.7 or the group --CR.sub.8 R.sub.9 --;R.sub.1, r.sub.2, r.sub.3 and R.sub.4 represent hydrogen, hydroxy, halogen, alkyl (1-6 C), alkoxy (1-6 C), alkylthio (1-6 C) or trifluoromethyl;R.sub.5 and R.sub.6 represent hydrogen, alkyl (1-6 C), aralkyl (7-10 C) or together in combination with the nitrogen atom a heterocyclic five- or six-membered ring;R.sub.7 stands for hydrogen or alkyl (1-4 C);R.sub.8 and R.sub.9 stand for hydrogen or methyl,n is the number 0, 1 or 2 andThe dotted line means an optional C--C bond,With valuable central nervous system (CNS) activities, especially antidepressant activity.

Abstract: A compound capable of forming a color on contact with an electron accepting compound and useful as a chromogenic material for recording members represented by the general formula (I) ##STR1## wherein A represents an oxygen atom or a group capable of forming a lactam ring with benzen ring D; Y represents a hydrogen atom or a functional group (such as a halogen atom or a nitro group); and when A is an oxygen atom, R represents an amino, i.e., unsubstituted, group or a substituted amino group; R.sub.1 and R.sub.3, which may be the same or different, each represents a hydrogen atom, a lower alkyl group, a nitro group, an amino group, or a substituted amino group; and R.sub.2 represents a hydrogen atom or a lower alkyl group; wherein R.sub.1 and R.sub.2 or R.sub.2 and R.sub.3 may combine with benzene ring C to form a nitrogen-containing heterocyclic ring condensed therewith; and when A is a group capable of forming a lactam ring with benzene ring D, R represents ##STR2## R.sub.2 represents ##STR3## R.sub.4 ', R.

Abstract: N-(1,1-dioxotetrahydro-3-thienyl)-2,6-dialkylmorpholines, useful as catalysts in making polyurethane foam.

Abstract: A 1,3-dithiolan-2-ylidene malonate derivative having the formula, ##STR1## wherein R.sup.1 and R.sup.2, which may be same or different, represent individually a C.sub.1 -C.sub.4 alkyl group; and R.sup.3 represents a chloromethyl group, a phenyl group, a group of the formula ##STR2## (where R.sup.4 and R.sup.5 represent individually a C.sub.1 -C.sub.4 alkyl group, or may form, in combination, a lower alkylene group which is sometimes intercepted by an oxygen atom), or a group of the formula ##STR3## (where M represents a hydrogen atom or a salt-forming residue; and A represents a lower alkylene group, a lower alkylene group, a phenylene group or a cyclohexenylene group), has effects of stimulating, improving and recovering the functions of livers, and can prevent, alleviate and cure various liver damages of humans and animals when administered thereto either orally or parenterally.

Abstract: Compounds having the formula ##STR1## and the pharmaceutically acceptable salts thereof, wherein R.sub.1 is hydrogen, halogen, trifluoromethyl, alkyl, alkoxy, nitro, amino, or hydroxy; R.sub.2 is carboxyl or alkoxycarbonyl; and n is 0, 1, 2, 3, 4 or 5; have antiinflammatory activity.

Abstract: 1,3-Benzodithiole-2-one and 1,3-benzodithiole-2-thione compounds are disclosed including the novel method of preparing said compounds and their biocidal activity.

Abstract: Novel morpholine compounds of the formula: ##STR1## wherein R.sub.1 represents hydrogen or C.sub.1 -C.sub.4 alkyl, R.sub.2 represents hydrogen, C.sub.1 -C.sub.4 alkyl, C.sub.3 -C.sub.5 alkenyl, C.sub.3 -C.sub.5 alkynyl, aryl-(C.sub.1 -C.sub.4)alkyl, (C.sub.3 -C.sub.6)cycloalkyl(C.sub.1 -C.sub.4)alkyl, polyhalo(C.sub.2 -C.sub.4)alkyl or hydroxy(C.sub.2 -C.sub.4)alkyl, A represents straight or branched C.sub.2 -C.sub.4 alkylene, B represents a divalent radical selected from the group consisting of --CH.sub.2 --CH.sub.2 --, --CH.dbd.CH--, ##STR2## --CH.sub.2 --O--, --CH.sub.2 --S--, --S-- and --O--, >D --E-- represents a trivalent radical selected from the group consisting of >CH--CH.sub.2 -- and >C.dbd.CH-- and C.sub.1 and C.sub.2 each represent 1,2-phenylene optionally substituted with one or more substituents selected from the group consisting of halogen, C.sub.1 -C.sub.4 alkyl and C.sub.1 -C.sub.

Abstract: Compounds are provided of the structure ##STR1## WHEREIN X--Z--Y together with two carbons of the cycloalkyl ring form a 5- or 6-membered ring, wherein R.sup.1 is hydrogen, aralkyl or acyl, n is 0, 1 or 2, and n' is 0, 1, 2 or 3, R.sup.2 is hydrogen, lower alkyl or aralkyl, R.sup.3 is hydrogen, acyl, lower alkyl, aralkyl, lower alkoxy, carboxy, halo, alkenyl, nitro, cycloalkyl, amino, acylamino, R.sup.2 O(CH.sub.2).sub.n 2 where n.sup.2 is 0, 1 or 2 or dihydroxyalkyl, X and Y may be the same or different and can be --CH.sub.2 --, .dbd.N--, --O--, --S--, --NR.sup.4 --, --O--CH.sub.2 --, --S--CH.sub.2 --, or --NR.sup.4 --CH.sub.2 -- where R.sup.4 is hydrogen, lower alkyl or aryl, Z can be ##STR2## where R.sup.5 and R.sup.6 can be hydrogen, lower alkyl, cycloalkyl, aryl, haloalkyl, amino or substituted or unsubstituted aminoalkyl; ##STR3## and --X--Z--Y-- can be taken together to form ##STR4## and ##STR5## These compounds are useful as anti-fibrillatory agents, disinfectants and water-softeners.

Abstract: Compounds having the formula ##STR1## wherein R.sub.1 and R.sub.2 are alkyls or alkenyls having 1 to 4 atoms or ##STR2## is pyrrolidino, piperidino, perhydroazepino or morpholino, and RX is a salt-forming moiety. The compounds are prepared by reacting 2-acetyl benzothiophene with ##STR3## The compounds possess a blood plaque aggregation inhibiting property and also possess spasmolytic, analgesic, anti-inflammatory and coronary, cerebral and peripheral vasodilatatory properties.

Abstract: 2-Oximino-1,3,5-trithiane compounds are useful intermediates in the preparation of 1,3,5-trithiane carbamoyloxime compounds which exhibit outstanding pesticidal activity.

Abstract: Disclosed are basic dyes, e.g., azo dyes and anthraquinone dyes free from sulphonic acid groups and which contain, as characteristic group, a group of the formula ##STR1## in which R and R.sub.1, independently, are substituted or unsubstituted C.sub.1-4 alkyl or are linked to form a ring, orOne of R and R.sub.1 is --NH.sub.2 or C.sub.1-4 alkoxy, the other substituted or unsubstituted alkyl,R.sub.2 and R.sub.3, independently, are hydrogen or C.sub.1-4 alkyl,Y is a bridging group,Q is unsubstituted or substituted phenyl, biphenylyl, naphthyl or ##STR2## in which R.sub.7 is ##STR3## where R.sub.8 ic C.sub.1-4 alkyl, andA.sup.- is an anion. These dyes are useful for the dyeing and printing of polymers and copolymers of acrylonitrile and asymmetrical dicyanoethylene as well as polyesters and polyamides modified to contain acid groups. The dyes build-up well and exhibit good pH stability and stability to boiling.

Abstract: New 3-amino-phenylacetic acid compounds of the formula: ##STR1## wherein X is hydrocarbyloxy or hydrocarbylthio optionally substituted by halogen, alkoxy, aryloxy, alkylmercapto or arylmercapto, or X is mono- or disubstituted amino, or represent a 5- to 8-membered heterocyclic ring;Y is oxygen or sulfur;Z is optionally substituted hydrocarbyl or hydrocarbyloxy or -thio, or Z can represent mono- or disubstituted amino, or a closed heterocyclic ring;Possess outstanding herbicidal activity, both pre-emergence and post-emergence.

Abstract: Novel compounds identified as acetal derivatives of 4-(substituted amino)-3,5-dinitrobenzaldehydes, effective as herbicides, and intermediates for their preparation.

Abstract: Processes for the production of the compounds of the formula: ##STR1## are disclosed. In the above formula, R.sub.1 is aryl which may be substituted or unsubstituted; R.sub.2 is hydrogen, alkyl, aryl, aralkyl, alkoxy, halogen, cyano, nitro, trifluoromethyl and the like.These compounds are prepared by the following reaction schemes: ##STR2## These compounds are useful as anti-inflammatory agents.