Processes Patents (Class 544/186)
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Patent number: 8188269Abstract: The present invention relates to improved covalent coupling of two or more entities such as biomolecules, polymer compositions, organic/inorganic molecules/materials, and the like, including their combinations, through one or more novel reactive groups attached to linker groups of 2-1000 atoms length. The present invention also contemplates the use of bifunctional bridge molecules to link two or more entities, wherein the functional groups of the bridge molecules are the novel reactive groups of the present invention.Type: GrantFiled: May 12, 2008Date of Patent: May 29, 2012Assignee: Luminex CorporationInventors: Ananda G. Lugade, Kurt D. Hoffacker, Adam J. Jenkins, Karri L. Michael-Ballard, Leonid Patsenker, Ewald Terpetschnig, Veronica D. Thomason, Ralph McDade
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Patent number: 7977476Abstract: Disclosed are methods of attaching biologically active compounds to a solid surface, comprising modifying the solid surface using triazine chloride and attaching the biologically active compound to the triazine moiety.Type: GrantFiled: January 3, 2011Date of Patent: July 12, 2011Assignee: Illumina, Inc.Inventors: Chanfeng Zhao, Igor Kozlov, Galina Steinberg-Tatman
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Patent number: 7863058Abstract: Disclosed are methods of attaching biologically active compounds to a solid surface, comprising modifying the solid surface using triazine chloride and attaching the biologically active compound to the triazine moiety.Type: GrantFiled: February 2, 2009Date of Patent: January 4, 2011Assignee: Illumina, Inc.Inventors: Chanfeng Zhao, Igor Kozlov, Galina Steinberg-Tatman
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Patent number: 7456276Abstract: A polymer substrate functionalized with a functionality comprising at least one cyclic, metal ion coordinating ligand group, the cyclic ligand group comprising at least 3 metal ion coordinating donor atoms independently selected from the group consisting of N, O and S.Type: GrantFiled: November 12, 2002Date of Patent: November 25, 2008Assignees: Novo Nordisk A/S, Monash UniversityInventors: Thorkild Christensen, William Milton Thomas Hearn, Leone Spiccia, Wei Jiang, Therese Jane Mooney, Bimbil Graham
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Patent number: 7169795Abstract: The present application describes sulfonylaminovalerolactams and derivatives thereof of Formula Ia–If: or pharmaceutically acceptable salt forms thereof, wherein ring G is a mono- or bicyclic carbocycle or heterocycle. Compounds of the present invention are useful as inhibitors of trypsin-like serine proteases, specifically factor Xa.Type: GrantFiled: September 28, 2004Date of Patent: January 30, 2007Assignee: Bristol Myers Squibb CompanyInventors: Wei Han, Zilun Hu, Timur Gungor
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Publication number: 20030134840Abstract: The invention provides compounds of general formula 1Type: ApplicationFiled: January 9, 2003Publication date: July 17, 2003Applicant: AstraZeneca AB, a Sweden corporationInventors: Andrew Baxter, Stephen Brough, Nicholas Kindon, Thomas Mclnally, Bryan Roberts, Stephen Thom
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Patent number: 6579328Abstract: Sterically hindered N-substituted aryloxyamines are prepared by the transition-metal-catalyzed decomposition of diazonium salts in the presence of a sterically hindered nitroxyl radical. These compounds are useful as thermal and light stabilizers for a variety of organic substrates.Type: GrantFiled: April 2, 2001Date of Patent: June 17, 2003Assignee: Ciba Specialty Chemicals CorporationInventors: Stephen D. Pastor, Sai Ping Shum
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Patent number: 5935954Abstract: The present invention relates to compounds that can maintain, increase, or restore sensitivity of cells to therapeutic or prophylactic agents. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well-suited for treatment of multi-drug resistant cells, for prevention of the development of multi-drug resistance, and for use in multi-drug resistant cancer therapy.Type: GrantFiled: October 30, 1997Date of Patent: August 10, 1999Assignee: Vertex Pharmaceuticals IncorporatedInventors: David M. Armistead, Jeffrey O. Saunders
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Patent number: 5296633Abstract: The methylated tertiary amines are selectively prepared by reacting a primary or secondary amine, or a nitrile or aminonitrile, including an aminoalcohol, etheramine, a polyamine or fatty polyamine or amidoamine, or amidopolyamine or dinitrile, with hexamethylenetetramine ("HMTA"), under hydrogen pressure at a temperature no greater than about 160.degree. C. and in the presence of a catalytically effective amount of a hydrogenation catalyst, e.g., nickel deposited onto appropriate support substrate therefor.Type: GrantFiled: December 30, 1992Date of Patent: March 22, 1994Inventor: Stephane Fouquay
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Patent number: 5245031Abstract: Compounds of the formula ##STR1## wherein X is an anion selected from the group consisting of phosphate, borate and molybdate groups, and a method for making these compounds. The compounds are useful in the control of microorganisms in aqueous systems and in the inhibition of corrosion of metal surfaces in contact with aqueous systems.Type: GrantFiled: July 19, 1991Date of Patent: September 14, 1993Assignee: Buckman Laboratories International, Inc.Inventors: John D. Pera, S. Rao Rayudu
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Patent number: 5187274Abstract: In a process to avoid the formation of waste water in the production of hexamine from ammonia and the stream of gas containing formaldehyde resulting from the catalytic oxidation of methanol on metallic oxide catalysts, or by oxidative dehydrogenation to formaldehyde, the liquid volume during reaction for the production of hexamine is kept constant, and carbon monoxide, the organic components of the exhaust gas and also hydrogen, if present, are oxidized to carbon dioxide and water, thus avoiding an energy-consuming condensation of the condensable components from the stream of exhaust gas and their treatment.Type: GrantFiled: July 19, 1991Date of Patent: February 16, 1993Assignee: Josef Meissner GmbH & Co.Inventors: Heinrich Hermann, Gunther Pelster, Klaus Degener
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Patent number: 5177205Abstract: Method for obtaining an organic polycrystalline material having in particular electro-optical properties, said material obtained and an electro-optical modulator comprising said material.This method includes a stage (1) for preparing a powder having a size grading of 500 to 800 nm of an organic compound having a delocalized system of electrons .pi. and presenting a non-centrosymmetrical crystalline structure, as well as intramolecular load transfer groupings, a stage (2) for drying the powder under vacuum, a stage (3) for pre-pressing the powder under vacuum, and a hot stage (5) for the uniaxial compression of the dried powder under vacuum.This method enables polycrystalline materials to be obtained, said materials comprising elongated monocrystalline grains orientated according to a given direction.Type: GrantFiled: March 8, 1989Date of Patent: January 5, 1993Assignee: L'Etat Francais represente par le Ministre des Postes, des Telecommunications et de l'Espace (Centre National d'Etudes des Telecommunications)Inventors: Jean Flicstein, Denise Morin
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Patent number: 5070137Abstract: Disclosed is a process for preparing isocyanurate-type polyisocyanates characterized by reacting an aliphatic or alicyclic diisocyanate compound comprising hexamethylene diisocyanate as a major component in the presence of an isocyanuration catalyst represented by general formula [I], ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 independently represent a hydrocarbon group containing 1 to 20 carbon atoms, or a hydrocarbon group containing one or more hetero atoms; at least two of R.sup.1, R.sup.2 and R.sup.3 may be linked to each other; R.sup.4 indicates a hydrogen atom or a hydrocarbon group containing 1 to 20 carbon atoms; and R.sup.5, R.sup.6 and R.sup.7 independently represent a hydrocarbon group containing 1 to 20 carbon atoms. Diol-modified isocyanurate-type polyisocyanates can be prepared additionally using a hydrocarbon diol in the process.Type: GrantFiled: July 21, 1989Date of Patent: December 3, 1991Assignee: Dainippon Ink and Chemicals, Inc.Inventors: Mitsuo Kase, Yoichi Kawasaki, Noboru Okoshi
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Patent number: 5061797Abstract: Compounds of the formula ##STR1## wherein X is an anion selected from the group consisting of phosphate, borate and molybdate groups, and a method for making these compounds. The compounds are useful in the control of microorganisms in aqueous systems and in the inhibition of corrosion of metal surfaces in contact with aqueous systems.Type: GrantFiled: March 29, 1988Date of Patent: October 29, 1991Assignee: Buckman Laboratories International, Inc.Inventors: John D. Pera, S. Rao Rayudu
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Patent number: 4920107Abstract: A method of preserving an aqueous system which is susceptible to microbiological degradation, comprising the step of adding to the system a compound having the formula ##STR1## wherein X is an anion selected from the group consisting of sulfate, acetate and citrate groups, and wherein the compound is added in an amount sufficient to inhibit the growth and proleferation of at least one microogranism in the aqueous system.The compounds 1-methyl-3,5,7-triaza-1-azoniatricyclodecane acetate and 1-methyl-3,5,7-triaza-1-azoniatricyclodecane citrate, and a method for preparing these compounds comprising the reaction of ammonium citrate, or ammonium acetate, with methylamine, formaldehyde and ammonia in an aqueous medium.Type: GrantFiled: March 29, 1988Date of Patent: April 24, 1990Assignee: Buckman Laboratories International, Inc.Inventors: John D. Pera, S. Rao Rayudu
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Patent number: 4892583Abstract: A method of preserving an aqueous system which is susceptible to microbiological degradation, comprising the step of adding to the system a compound having the formula ##STR1## wherein the compound is added in an amount sufficient to inhibit the growth and proliferation of at least one microorganism in the aqueous system.The compound 1-methyl-3,5,7-triaza-1-azoniatricyclodecane triiodide and a method for preparing same comprising the substitution of triiodide anion for a monohalide anion in an aqueous medium.Type: GrantFiled: November 4, 1988Date of Patent: January 9, 1990Assignee: Buckman Laboratories International, Inc.Inventor: S. Rao Rayudu
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Patent number: 4650866Abstract: A process for preparing 1-methyl-3,5,7-triaza-1-azoniatricyclodeane halides. Ammonium halide, methylamine, formaldehyde and ammonia are reacted in an aqueous system.Type: GrantFiled: March 6, 1986Date of Patent: March 17, 1987Assignee: Buckman Laboratories, Inc.Inventor: S. Rao Rayudu
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Patent number: 4578506Abstract: The title compounds, having the formula (RO.sub.2 CNHCH.sub.2).sub.3 PY where Y=oxygen or sulfur, are prepared by reacting a tetrakis(N-carbalkoxylaminomethyl)phosphonium salt having the formula (RO.sub.2 CNHCH.sub.2).sub.4 P.sup.+ X.sup.- with ammonia or a primary or secondary amine, followed by an oxidizing or sulfurizing agent. The products, after methylolation with formaldehyde, are useful as finishing agents for imparting flame retardant properties to cotton fabrics.Type: GrantFiled: March 8, 1982Date of Patent: March 25, 1986Assignee: The United States of America as represented by the Secretary of AgricultureInventor: Arlen W. Frank
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Patent number: 4469691Abstract: Hexamethylenetetramine-N-acetyl-thiazolidine-4-carboxylate having formula (I) ##STR1## is endowed with antibacterial and mucosecretolytic properties. These properties along with the very low toxicity of the compound (I) make it particularly suited for the chemotherapeutical treatment of the affections of the urinary and intestinal tracts, and for the treatment of bladder and intestinal catarrhs.Type: GrantFiled: November 12, 1982Date of Patent: September 4, 1984Assignee: Ausonia Farmaceutici s.r.l.Inventor: Leonardo De Vincentiis
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Patent number: 4237283Abstract: Disclosed herein is a process for producing dry compositions containing thiocyanic acid and hexamethylene-tetramine wherein hexamethylene-tetramine is reacted with an alkali or alkaline earth metal thiocyanate in the aqueous phase in the presence of acid, and wherein the aqueous reaction product solution, without isolation of the reaction product, is combined with an inert carrier substance and dried.Type: GrantFiled: August 15, 1979Date of Patent: December 2, 1980Assignee: Meggle Milchindustrie GmbH & Co.Inventors: Robert Engl, Hans Richter
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Patent number: 4188386Abstract: Disclosed herein is a process for producing dry compositions containing thiocyanic acid and hexamethylene-tetramine wherein hexamethylene-tetramine is reacted with an alkali or alkaline earth metal thiocyanate in the aqueous phase in the presence of acid, and wherein the aqueous reaction product solution, without isolation of the reaction product, is combined with an inert carrier substance and dried.Type: GrantFiled: November 7, 1977Date of Patent: February 12, 1980Assignee: Meggle Milchindustrie GmbH & Co. KGInventors: Robert Engl, Hans Richter
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Patent number: 4158045Abstract: Wet scrubbing process for cleaning waste gases containing formaldehyde such as those produced in the manufacture of fiber glass insulation has substantial advantages over alternative thermal incineration process in that it requires less capital equipment expense and utilizes far less energy for handling equal volumes of waste gases. The gases are scrubbed in two scrubbing zones, the first of which contains hexamethylenetetramine and ammonium hydroxide to which ammonia is added and the second of which has water added to it. A part of the second scrubbing solution is introduced into the first scrubbing solution and a part of the first scrubbing solution is drawn off from the system.Type: GrantFiled: December 12, 1977Date of Patent: June 12, 1979Assignee: UOP Inc.Inventors: Johann Schaffer, Willi Horrix
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Patent number: 4088818Abstract: Formaldehyde present in a waste water containing lower carboxylic acids is recovered by reacting said waste water at 0.degree. to 90.degree. C. with the amount of ammonia required for converting said formaldehyde into hexamine and the latter is recovered in solid form by evaporating the resulting solution.The solid hexamine thus recovered has a content in lower carboxylic acids not exceeding 0.05 wt.%, is practically free from other impurities and is suited for any conventional use.Type: GrantFiled: June 3, 1976Date of Patent: May 9, 1978Assignee: Societa Italiana Resine S.I.R. S.p.A.Inventors: Pierino Radici, Pietro Erini, Umberto Santini, Paolo Colombo
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Patent number: 4069220Abstract: A process has been developed for producing complexes of phenol or phenolic compounds and hexamethylenetetramine by mixing the ingredients with only enough water, or other suitable solvent, to promote the reaction. Heat liberated by the reaction is controlled by cooling the mixing chamber, and drying is accomplished by removing the small amount of solvent in conventional type dryers.Type: GrantFiled: September 21, 1976Date of Patent: January 17, 1978Assignee: Jim Walter Resources, Inc.Inventors: Henry Philip Orem, David R. Hart, Jerry E. Hill
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Patent number: RE29883Abstract: A number of water-soluble, one-to-one quaternary ammonium adducts of unsaturated organic halides and dihalides with hexamethylenetetramine are known as being useful as antimicrobial agents. It has now been discovered that a two-to-one quaternary ammonium adduct can be prepared from hexamethylenetetramine and 3,4-dichlorobutene-1; this two-to-one adduct is a more active, less toxic antimicrobial agent than the known one-to-one quaternary ammonium adducts.Type: GrantFiled: May 25, 1977Date of Patent: January 16, 1979Assignee: Cosan Chemical CorporationInventors: Jerome S. Luloff, Albert L. Eilender