Additional Ring Containing Patents (Class 544/197)
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Publication number: 20120202814Abstract: The present invention relates to the medical use of the compound of formula 1, 2, 3 or 4:Type: ApplicationFiled: October 4, 2010Publication date: August 9, 2012Applicants: UNIVERSITÀ DEGLI STUDI DI SIENA, CONSIGLIO NAZIONALE DELLE RICERCHEInventors: Marco Radi, Maurizio Botta, Federico Falchi, Giovanni Maga, Fausto Baldanti, Stefania Paolucci
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Patent number: 8221730Abstract: UV-photoprotective sunscreen compositions contain at least one novel silanic p-aminobenzalmalonate-substituted s-triazine compound having the general formula (I):Type: GrantFiled: July 8, 2011Date of Patent: July 17, 2012Assignee: L'OrealInventor: Hervé Richard
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Patent number: 8221728Abstract: UV-photoprotective sunscreen compositions contain at least one novel silanic p-aminobenzalmalonate-substituted s-triazine compound having the general formula (I):Type: GrantFiled: February 23, 2005Date of Patent: July 17, 2012Assignee: L'OrealInventor: Herve Richard
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Patent number: 8212032Abstract: The invention is directed to novel sEH inhibitors and their use in the treatment of diseases mediated by the sEH enzyme. Specifically, the invention is directed to (Cis)-N-{[4-cyano-2-(trifluoromethyl)phenyl]methyl}-3-{[4-methyl-6-(methylamino)-1,3,5-triazin-2-yl]amino}cyclohexanecarboxamide; or a pharmaceutically acceptable salt thereof, and N-{[4-cyano-2-(trifluoromethyl)phenyl]methyl}-3-{[4-methyl-6-(methylamino)-1,3,5-triazin-2-yl]amino}cyclohexanecarboxamide; or a pharmaceutically acceptable salt thereof.Type: GrantFiled: April 9, 2010Date of Patent: July 3, 2012Assignee: GlaxoSmithKline LLC.Inventors: Yun Ding, Reema K. Thalji, Joseph P. Marino, Jr.
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Publication number: 20120142647Abstract: The present invention includes compositions that are useful in the treatment of breathing control diseases or disorders in a subject in need thereof. The present invention also includes a method of treating a respiratory disease or disorder in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a pharmaceutical formulation of the invention. The present invention further includes a method of preventing destabilization or stabilizing breathing rhythm in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a pharmaceutical formulation of the invention.Type: ApplicationFiled: November 29, 2011Publication date: June 7, 2012Inventors: Scott L. Dax, Richard Woodward, Sean Peng
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Publication number: 20120142878Abstract: A resin with a favorable index of refraction and transparency even without using heavy atoms or inorganic oxide fine particles by means of a polymerizable monomer having a 1,3,5-triazine ring represented by formula 1. (In formula 1: A is a group represented by formula 2, (in formula 2: R1 represents a hydrogen atom or a methyl group, T represents an alkylene having 1-10 carbon atoms, and R2 represents O or NH), and B1 and B2 are each independently groups represented by formula 3, formula 4, or formula 5 (in formulas 3-5: R3, R4, and R5 represent an alkyl group having 1-10 carbon atoms, an aryl group, or an aryloxy group, n1 and n3 are integers from 0-5, and n2 is an integer from 0-7, however when there are at least two of each of R3, R4, and R5, these may be the same or different from each other).Type: ApplicationFiled: August 6, 2010Publication date: June 7, 2012Inventors: Kenichi Osawa, Takuro Oda
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Patent number: 8188273Abstract: (1,3,5)-Triazinyl phenyl hydrazones are effective at controlling insects.Type: GrantFiled: October 19, 2011Date of Patent: May 29, 2012Assignee: Dow AgroSciences, LLC.Inventors: Noormohamed M. Niyaz, Katherine A. Guenthenspberger, Ricky Hunter, Annette Vitale Brown, Jaime S. Nugent
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Patent number: 8173805Abstract: The invention is directed to novel sEH inhibitors and their use in the treatment of diseases mediated by the sEH enzyme. Specifically, the invention is directed to compounds according to Formula I: wherein R1, R2, R4, R5, R6, A, B, Y, Z, n, and m are defined below, and to pharmaceutically-acceptable salts thereof. The compounds of the invention are sEH inhibitors and can be used in the treatment of diseases mediated by the sEH enzyme, such as hypertension. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting sEH and treatment of conditions associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.Type: GrantFiled: October 10, 2008Date of Patent: May 8, 2012Assignee: GlaxoSmithKline, LLCInventors: Yun Ding, Reema K. Thalji, Joseph P. Marino, Jr.
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Patent number: 8163748Abstract: Novel s-triazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, where microbial infection is either a direct cause or a related condition.Type: GrantFiled: May 23, 2008Date of Patent: April 24, 2012Assignee: New York UniversityInventors: Neville Robert Kallenbach, Young-Tae Chang, Zhigang Liu, Chunhui Zhou, Jaeki Min
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Patent number: 8153788Abstract: Compounds of the formula (I) or salts thereof, in which in which R1 is an optionally substituted amino group or analogous group, and R2 to R7 are each as described herein, are suitable as herbicides and crop growth regulators. The compounds (I) can be prepared by the processes described, via intermediates including novel intermediates for example of the formula (III).Type: GrantFiled: December 14, 2007Date of Patent: April 10, 2012Inventors: Hartmut Ahrens, Hansjörg Dietrich, Thomas Auler, Martin Hills, Heinz Kehne, Dieter Feucht, Stefan Herrmann, Kristian Kather, Stefan Lehr
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Patent number: 8138338Abstract: The present invention provides, at least in part, compounds of formula (I): or a pharmaceutically acceptable salt thereof, wherein Z1, Z2, Z3, R1, x, y, R2, R3, R4a, R4b, R5, R6 and R7 are described herein, as well as methods for their identification, their preparation, pharmaceutical compositions containing them, and their use as Aurora A kinase inhibitors in treatment, e.g., of cancer and other proliferative disorders.Type: GrantFiled: July 27, 2007Date of Patent: March 20, 2012Assignee: GlaxoSmithKline LLCInventor: Matthew Clark
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Patent number: 8119798Abstract: Compounds of formula (I) and (II) are disclosed, as well as methods for their identification, their preparation, pharmaceutical compositions containing them, and their use in treating disease. The compounds inhibit the production of TNF-alpha and interleukins (IL) by the inhibition of p38 kinase. They are useful in the treatment of inflammation and arthritis.Type: GrantFiled: August 1, 2007Date of Patent: February 21, 2012Assignee: GlaxoSmithKline LLCInventor: Matthew Clark
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Publication number: 20120040837Abstract: (1,3,5)-Triazinyl phenyl hydrazones are effective at controlling insects.Type: ApplicationFiled: October 19, 2011Publication date: February 16, 2012Applicant: DOW AGROSCIENCES LLCInventors: Noormohamed M. Niyaz, Katherine A. Guenthenspberger, Ricky Hunter, Annette V. Brown, Jaime S. Nugent
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Publication number: 20120021253Abstract: [Problem] Provided is a novel lubricant composition that is useful as a material of a lubricating layer of a magnetic recording medium. [Means for Resolution] The lubricant composition contains at least one kind of compound represented by the following Formula (1). In the formula, X represents a cyclic group that may be substituted, and Y represents a single bond or a linking group having a valency of 2 or more. Here, at least one of X and Y includes 1 or more polar groups such as a hydroxyl group; Z represents a linking group having a valency of 2 or more and constituted with a carbon atom (C), a fluorine atom (F), and 1 or 2 kinds of arbitrary atoms (here, a hydrogen atom is excluded); n represents a real number of 1 to 10; m represents a real number of 0 to 1; and s and t independently represent a real number of 1 or greater.Type: ApplicationFiled: March 3, 2010Publication date: January 26, 2012Applicant: FUJIFILM CORPORATIONInventors: Hiyoku Nakata, Akiko Hattori, Atsushi Tatsugawa, Ken Kawata
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Patent number: 8067588Abstract: (1,3,5)-Triazinyl phenyl hydrazones are effective at controlling insects.Type: GrantFiled: September 26, 2008Date of Patent: November 29, 2011Assignee: Dow AgroSciences LLCInventors: Noormohamed M. Niyaz, Katherine A. Guenthenspberger, Ricky Hunter, Annette V. Brown, Jaime S. Nugent
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Publication number: 20110263846Abstract: UV-photoprotective sunscreen compositions contain at least one novel silanic p-aminobenzalmalonate-substituted s-triazine compound having the general formula (I):Type: ApplicationFiled: July 8, 2011Publication date: October 27, 2011Applicant: L'OREALInventor: Herve RICHARD
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Publication number: 20110237587Abstract: Disclosed herein are a 1,3,5-triazine-2,4,6-triamine compound or a pharmaceutically acceptable salt thereof, a preparation method thereof, and a composition for preventing or treating metabolic syndromes, diabetes, or cancers with deletion of P53 gene, which comprises the same.Type: ApplicationFiled: August 28, 2008Publication date: September 29, 2011Applicants: HANALL PHARMACEUTICAL COMPANY, LTD, KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGYInventors: Hyae Gyeong Cheon, Kwang-Rok Kim, Sang Dal Rhee, Won Hoon Jung, Jong-Cheol Lee, Sung Wuk Kim, Sung Soo Jun
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Publication number: 20110237665Abstract: The present invention relates to an agrochemical composition comprising pesticide and UV absorber, and the abovementioned UV absorbers. The invention furthermore relates to the use of the UV absorbers in agrochemical compositions. It moreover relates to a method of controlling phytopathogenic fungi and/or undesirable plant growth and/or undesirable insect or mite infestation and/or of regulating plant growth.Type: ApplicationFiled: November 30, 2009Publication date: September 29, 2011Applicant: BASF SEInventors: Andrea Misske, Christian Bittner, Michael Ishaque, Markus Hoffmann, Richard Riggs, Sens Ruediger, Andre Kabat, Sylke Haremza, Douglas D. Anspaugh, David M. Terry
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Publication number: 20110230489Abstract: Novel s-triazine compounds are disclosed that have a formula represented by the following: L1, L2, L3, R1, R2, R3, R4, R5a, R5b, and R5c are as described herein. The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, where microbial infection is either a direct cause or a related condition.Type: ApplicationFiled: March 17, 2011Publication date: September 22, 2011Inventor: Neville Robert KALLENBACH
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Patent number: 8008483Abstract: The invention is directed to novel sEH inhibitors and their use in the treatment of diseases mediated by the sEH enzyme. Specifically, the invention is directed to compounds according to Formula I: wherein R1, R2, R3, R5a, R6a A, B, Y, x, and m are defined below, and to pharmaceutically-acceptable salts thereof. The compounds of the invention are sEH inhibitors and can be used in the treatment of diseases mediated by the sEH enzyme, such as hypertension. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting sEH and treatment of conditions associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.Type: GrantFiled: October 10, 2008Date of Patent: August 30, 2011Assignee: Glaxosmithkline, LLCInventors: Yun Ding, Reema K. Thalji, Joseph P. Marino, Jr.
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Patent number: 7999101Abstract: The present invention relates to cationic lipids capable of forming complexes with nucleic acids and the use thereof for the transfection of eukaryotic cells. The cationic lipids according to the invention have general formulas (I) and (Ia): (see formulas (I) and (Ia), wherein E is a heteroaryl; R1 and R2 are selected from H, —R7—NH2, alkyl; R7 is selected from alkyl, alkenyl, aryl, (C1-C20) alkyl-aryl-(C0-C20) alkyl; R3 and R4 are selected from: H, —R8—SH, R8—NH—NH2/—R8—CO—R9 or —R8—NH2; R8 is selected from: alkyl, alkenyl, aryl, (C1-C20) alkyl-aryl-(C0-C20) alkyl; R9 is selected from: H, alkyl; R5 and R6 are selected from: H, alkyl, alkenyl, aryl, (C1-C20) alkyl-aryl.Type: GrantFiled: February 13, 2006Date of Patent: August 16, 2011Assignee: Politecnico Di MilanoInventors: Matteo Zanda, Luca Bruche′, Massimo Frigerio, Fiorenza Viani, Luca Chiamenti, Walter Panzeri, Nadia Zaffaroni, Marco Folini, Maria Angela Greco
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Patent number: 7994317Abstract: The invention is directed to novel sEH inhibitors and their use in the treatment of diseases mediated by the sEH enzyme.Type: GrantFiled: November 2, 2007Date of Patent: August 9, 2011Assignee: GlaxoSmithKline, LLCInventors: Yun Ding, Joseph Paul Marino, Jr., Peng Li, Allyn T. Londregan, Barry A. Morgan
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Patent number: 7989576Abstract: A triazine derivative represented by formula (I) below: where, in formula (I), each of M1a, M1b, M2a and M2b is a divalent group comprising one or more substituted or non-substituted aromatic rings; each of n1 and n2 is 0 or 1; each of R1 and R2 represents a hydrogen atom or substituent; and X represents a substituent; is disclosed.Type: GrantFiled: February 28, 2008Date of Patent: August 2, 2011Assignee: Fujifilm CorporationInventors: Aiko Yoshida, Hiroshi Takeuchi
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Patent number: 7982034Abstract: The present invention provides hydrophobic prodrugs of bases, nucleosides, and nucleotides as well as methods of using the prodrugs as antiviral and anti-cancer chemotherapeutic agents.Type: GrantFiled: April 7, 2009Date of Patent: July 19, 2011Assignee: Koronis Pharmaceuticals, IncorporatedInventors: Richard Daifuku, Alexander Gall, Dmitri Sergueev, Dina Sologub, Kevin Harris
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Publication number: 20110171437Abstract: A mixture of compounds of Formula (1) and salts thereof: wherein: Pc represents a phthalocyanine nucleus; R1 is H or optionally substituted C1-8alkyl; R2, R3, R4, R5 and R7 are each independently H or methyl; R6 is H, methyl or aryl carrying 1 to 3 carboxy groups and optionally other substituents; R8 is aryl, carrying 1 to 3 carboxy groups and optionally other substituents; L is optionally substituted C1-4alkylene; x, y, and z are each independently greater than 0 and less than 4; x+y+z is in the range of 2 to 4; and provided that: the substituents represented by x, y and z are attached to the phthalocyanine nucleus by a ?-position; and L, R1, R6 and R8 do not carry a sulfonic acid substituent. Also compositions, novel amines, printed material and ink-jet cartridges.Type: ApplicationFiled: September 22, 2009Publication date: July 14, 2011Inventor: Prakash Patel
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Patent number: 7943614Abstract: A carboxamide compound represented by the formula (I): [wherein Q represents a nitrogen-containing 6-membered aromatic heterocyclic group optionally fused with a benzene ring, two or more ring constitutional atoms of the heterocyclic group are a nitrogen atom, and the heterocyclic group may be substituted with at least one group selected from the group consisting of a C1-C3 alkyl group etc.], and a plant disease controlling agent comprising this as an active ingredient.Type: GrantFiled: July 12, 2006Date of Patent: May 17, 2011Assignee: Sumitomo Chemical Company, LimitedInventors: Sadayuki Arimori, Yoshiharu Kinoshita
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Publication number: 20110097365Abstract: The invention relates to novel s-triazine derivatives containing at least two particular silane aminobenzoate or silane aminobenzamide groups and to their cosmetic uses. The invention also relates to photoprotective compositions comprising s-triazine derivatives containing at least two particular grafted silane aminobenzoate or silane aminobenzamide groups as sunscreens that are active in the UV-B radiation range.Type: ApplicationFiled: September 9, 2008Publication date: April 28, 2011Applicant: L'OREALInventor: Herve Richard
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Publication number: 20110064892Abstract: This invention relates to polycyclic organic compounds of general structural formula (I): wherein Y is a predominantly planar polycyclic system being at least partially aromatic, W1, W2, and W3 are different groups providing solubility in an organic solvent, and sum (n1+n2+n3) is 1, 2, 3, 4, 5, 6, 7 or 8. The polycyclic organic compounds are substantially transparent for electromagnetic radiation in the visible spectral range and are capable of forming supramolecules in the organic solvent.Type: ApplicationFiled: March 4, 2009Publication date: March 17, 2011Inventors: Alexey Nokel, Pavel I. Lazarev
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Publication number: 20110003989Abstract: A melamine skeleton-bearing organosilicon compound has a film forming ability, water solubility and compatibility with resins. It is prepared by reacting cyanuric chloride with a primary and/or secondary amine compound and neutralizing with a base.Type: ApplicationFiled: June 30, 2010Publication date: January 6, 2011Inventor: Kazuhiro TSUCHIDA
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Patent number: 7858782Abstract: The invention provides for Triazine derivatives and their use to modulate protein kinase activity in a variety of conditions and diseases.Type: GrantFiled: December 14, 2007Date of Patent: December 28, 2010Assignee: Abraxis BioScience, LLCInventors: Chunlin Tao, Qinwei Wang, Neil P. Desai, Patrick Soon-Shiong
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Publication number: 20100298200Abstract: The present invention relates to the field of therapeutic methods to screen for compounds on the basis of their ability to influence Wnt activity. The screening process is applied to both a physical library of a series of compounds and a virtual library of compounds that affect Wnt activity. In one aspect, the virtual screening process could be carried out where a permutational library of small peptides is substituted for the small organic molecules. The inventive methods may be used to empirically test for effects on Wnt activity and may also be applied to any pair of proteins involved in protein-protein interactions.Type: ApplicationFiled: May 22, 2009Publication date: November 25, 2010Inventors: Dakai Liu, Xiaofeng Li, Richard Jin, Yuaxin Liang, Wei Cheng, Riddhi Bhattacharyya, Guangrong Zhang
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Publication number: 20100292409Abstract: The present invention relates to triazine derivatives of the general formula (I), their use and production.Type: ApplicationFiled: May 29, 2008Publication date: November 18, 2010Applicant: BOREALIS AGROLINZ MELAMINE GMBHInventors: Rene Dicke, Martin Burger, Christoph Hahn, Andreas Endersfelder
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Publication number: 20100258790Abstract: The present invention relates to an organic light-emitting diode comprising at least one diphenylaminobis(phenoxy)triazine or at least one bis(diphenylamino)phenoxytriazine compound, to a light-emitting layer comprising at least one diphenylamino-bis(phenoxy)triazine or at least one bis(diphenylamino)phenoxytriazine compound, to the use of the aforementioned compounds as a matrix material, hole/exciton blocker material, electron/exciton blocker material, hole injection material, electron injection material, hole conductor material and/or electron conductor material, and to a device selected from the group consisting of stationary visual display units, mobile visual display units and illumination units comprising at least one inventive organic light-emitting diode.Type: ApplicationFiled: October 21, 2008Publication date: October 14, 2010Applicant: BASF SEInventors: Evelyn Fuchs, Nicolle Langer, Christian Lennartz, Peter Strohriegl, Michael Rothmann
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Publication number: 20100129350Abstract: We describe compounds of the following general formula (I): wherein X is fluorine or chlorine; Y is oxygen, sulfur, or an amino group; R is an amino, hydroxyl, sulfonamide, or carboxamide group or an N-monomethyl or N-dimethyl analog thereof; m is an integer from 2 to 6, and n is an integer from 0 to 2. The compounds may be used for treating certain cancers and autoimmune diseases.Type: ApplicationFiled: April 25, 2008Publication date: May 27, 2010Applicant: PROMETIC BIOSCIENCES INC.Inventors: Boulos Zacharie, Christopher Penney, Lyne Gagnon, Brigitte Grouix, Lilianne Geerts, Shaun D. Abbott
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Patent number: 7718655Abstract: Trisubstituted triazines can be synthesized from cyanuric chloride. These compounds are useful anti-tubulin agents for treating cancer and proliferative diseases.Type: GrantFiled: June 20, 2003Date of Patent: May 18, 2010Assignee: New York UniversityInventors: Young-Tae Chang, Alexander Schier, Ho-Sang Moon, Eric Jacobson, Puja Parikh
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Publication number: 20100120772Abstract: Compounds of formula (I) and (II) are disclosed, as well as methods for their identification, their preparation, pharmaceutical compositions containing them, and their use in treating disease. The compounds inhibit the production of TNF-alpha and interleukins (IL) by the inhibition of p38 kinase. They are useful in the treatment of inflammation and arthritis.Type: ApplicationFiled: August 1, 2007Publication date: May 13, 2010Inventor: Matthew Clark
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Publication number: 20090325966Abstract: Novel s-triazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, where microbial infection is either a direct cause or a related condition.Type: ApplicationFiled: May 23, 2008Publication date: December 31, 2009Inventors: Neville Robert Kallenbach, Young-Tae Chang, Zhigang Liu, Chunhui Zhou, Jaeki Min
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Patent number: 7608620Abstract: The invention relates to triazines and the use thereof to inhibit lysophosphatidic acid acyltransferase ? (LPAAT-?) activity. The invention further relates to methods of treating cancer using said triazines. The invention also relates to methods for screening for LPAAT-? activity.Type: GrantFiled: November 16, 2006Date of Patent: October 27, 2009Assignee: Cell Therapeutics, Inc.Inventors: Lynn Bonham, Baoqing Gong, Robert E Finney, David M Hollenback, J Peter Klein, David W Leung, Scott A Shaffer, Norina M Tang, John Tulinsky, Thayer H White
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Patent number: 7592451Abstract: The present invention relates to a compound having the formula where Z is an amine, phenoxy, or thiol-containing group, and Y is an alkyl-containing amine. Methods of producing such compounds and using them to treat patients with diabetes and obesity are also disclosed. The present invention also relates to treating such conditions with GADPH inhibitors and screening compounds useful for treating such conditions by using GADPH inhibitors. Compounds can also be screened for their effectiveness in modulating diabetes and obesity with a C. elegans strain.Type: GrantFiled: June 20, 2006Date of Patent: September 22, 2009Assignee: New York UniversityInventors: Young-Tae Chang, Fabio Piano
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Patent number: 7589092Abstract: The present invention provides hydrophobic prodrugs of bases, nucleosides, and nucleotides as well as methods of using the prodrugs as antiviral and anti-cancer chemotherapeutic agents.Type: GrantFiled: December 27, 2006Date of Patent: September 15, 2009Assignee: Koronis Pharmaceuticals, IncorporatedInventors: Richard Daifuku, Alexander Gall, Dmitri Sergueev, Dina Sologub, Kevin Harris
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Publication number: 20090162878Abstract: The present invention provides methods (assays) for detecting and/or quantifying sAPP?, a secreted ?-secretase (BACE1) cleavage fragment of the ?-amyloid precursor protein (APP), in a biological sample. One such method includes contacting a biological sample with a first antibody that selectively binds to a BACE1 cleavage site on sAPP? and detecting the presence of the antibody. Also provided are compositions, including antibodies that selectively bind to the BACE1 cleavage site of sAPP?. Kits containing such compositions are also provided. Methods of diagnosing a neurodegenerative disease, such as AD, using the methods and compositions of the present invention are further provided. Methods for identifying BACE1 modulators, candidate compounds that are BACE1 modulators, and methods for treating, preventing or ameliorating neurodegenerative disease, such as AD, using such compounds or pharmaceutical compositions containing such compounds are also provided.Type: ApplicationFiled: January 13, 2009Publication date: June 25, 2009Inventors: Tae-wan Kim, Jeremy C. Hwang
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Patent number: 7534421Abstract: Stable, topically applicable cosmetic/dermatological sunscreen compositions, well suited for the UV-photoprotection of human skin/keratinous materials, contain a thus effective amount of at least one novel s-triazine compound bearing at least one para-aminobenzalmalonic salt substituent.Type: GrantFiled: February 27, 2004Date of Patent: May 19, 2009Assignee: L'OrealInventors: Hervé Richard, Bernadette Luppi
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Patent number: 7517474Abstract: New triazine derivatives containing carbamate groups, processes for preparing them, and their use.Type: GrantFiled: April 8, 2005Date of Patent: April 14, 2009Assignee: BASF AktiengesellschaftInventors: Eva Wagner, Reinhold Schwalm, Joerg Schneider, Rainer Erhardt, Carl Jokisch, Heinz-Peter Rink
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Publication number: 20090068169Abstract: The present invention describes new compounds which are useful for binding to the tail or Fc portion of immunoglobulins and so have utility in those applications which require the non-covalent binding interaction of a molecule with the Fc portion of immunoglobulins. Such applications include the detection and purification of immunoglobulins as well as the treatment of certain autoimmune diseases.Type: ApplicationFiled: September 2, 2005Publication date: March 12, 2009Inventors: Christopher Penney, Boulos Zacharie, Shaun D. Abbott, Jean-Francois Bienvenu, Alan D. Cameron, Jean-Simon Duceppe, Abdallah Ezzitouni, Daniel Fortin, Karine Houde, Nancie Moreau, Nicole Wilb, Brigitte Grouix, Lyne Gagnon
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Publication number: 20090018305Abstract: A triazine derivative represented by formula (I) below: where, in formula (I), each of M1a, M1b, M2a and M2b is a divalent group comprising one or more substituted or non-substituted aromatic rings; each of n1 and n2 is 0 or 1; each of R1 and R2 represents a hydrogen atom or substituent; and X represents a substituent; is disclosed.Type: ApplicationFiled: February 28, 2008Publication date: January 15, 2009Inventors: Akio YOSHIDA, Hiroshi Takeuchi
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Publication number: 20080305102Abstract: Inhibition of synoviolin function was found to activate the cancer-suppressing protein p53. Substances inhibiting the function of synoviolin are useful as cancer therapeutic agents. The inhibition of synoviolin function was also found to lead to the inhibition of p53 ubiquitination, increased activity of p53 phosphorylation proteins, and the like. Based on these findings, the present invention provides methods capable of efficiently screening for cancer therapeutic agents. Further, it was also found that regulation of the autoubiquitination of synoviolin protein suppresses the proliferation of rheumatoid arthritis synovial cells. Substances regulating the autoubiquitination of synoviolin protein are useful as anti-rheumatic agents. Moreover, the present invention provides methods of efficiently screening for anti-rheumatic agents.Type: ApplicationFiled: June 23, 2006Publication date: December 11, 2008Inventors: Toshihiro Nakajima, Yukihiro Kato, Tadayuki Yamadera, Tetsuya Amano
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Publication number: 20080145324Abstract: UV-photostable, topically applicable cosmetic/dermatological compositions contain at least one dibenzoylmethane UV-sunscreen compound and at least one photostabilizing silicon-containing s-triazine compound substituted with two aminobenzoate or aminobenzamide groups.Type: ApplicationFiled: November 30, 2007Publication date: June 19, 2008Applicant: L'OREALInventors: Herve Richard, Didier Candau
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Patent number: 7375222Abstract: This invention relates to an anti-dementia agent which uses a BEC 1 potassium channel inhibitor as the active ingredient. It was proved that the BEC 1 potassium channel inhibitor has an action to improve learning disorder and is useful as a preventive or therapeutic agent for diseases, preferably dementia, in which the BEC 1 potassium channel is considered to be concerned. Illustratively, it was confirmed by an in vivo test that the BEC 1 potassium channel inhibitor has an action to improve learning disorder. Also, it was found that a compound having 2,4,6-triamino-1,3,5-triazine has a BEC 1 potassium channel inhibitory action.Type: GrantFiled: February 3, 2003Date of Patent: May 20, 2008Assignee: Astellas Pharma Inc.Inventors: Hideki Kubota, Takeshi Suzuki, Masanori Miura, Eiichi Nakai, Kiyoshi Yahiro, Akira Miyake, Shinobu Mochizuki, Kazuhiro Nakatou
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Patent number: 7375221Abstract: The present invention includes a method of making of azidoaminotriazole (5-azido-2H-[1,2,4]triazol-3-ylamine), nitrosoguanazine dimer (N3-[(1E)-3-(4,5-diamino-4H-1,2,4-triazol-3-yl)-1,2-dioxidotriaz-1-enyl]-4H-1,2,4-triazole-3,4,5-triamine), novel nitrosoguanazine salts, azidonitraminotriazole/salts and the making of azidonitraminotriazole and salts, and novel metal complexes of an azidonitramine (4,6-diazido-N-nitro-1,3,5-triazin-2-amine) and the making of these metal complexes of this azidonitramine. Azidoaminotriazole, nitrosoguanazine, and azidonitramine compounds, their intermediates, and their salts may generally relate to energetic compounds, while nitrosoguanazine compounds and their metal salts may also have commercial potential in biomedical and pharmaceutical applications.Type: GrantFiled: October 31, 2005Date of Patent: May 20, 2008Assignee: The United States of America as represented by the Secretary of the NavyInventors: John William Fronabarger, Michael E. Sitzmann, Michael D. Williams
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Patent number: 7335770Abstract: The present invention relates to triazine compounds and their analogs and derivatives, and methods and compositions comprising these compounds. The compounds and compositions of this invention are useful for, among other things, treating pathophysiological conditions arising from inflammatory responses, inhibiting or blocking glycated protein produced induction of the signaling-associated inflammatory response in endothelial cells, inhibiting smooth muscle proliferation, treating vascular occlusive conditions characterized by smooth muscle proliferation such as restenosis and atherosclerosis, and the like.Type: GrantFiled: March 24, 2004Date of Patent: February 26, 2008Assignee: Reddy U5 Therapeutics, Inc.Inventors: Richard T. Timmer, Christopher W. Alexander, Sivaram Pillarisetti, Uday Saxena, Sesha Sridevi Alluri, Velagala Venkata Rama Murali Krishna Reddy, Manojit Pal, Jangalgar Tirupathy Reddy, Koteswar Rao Yeleswarapu, Gaddam Om Reddy, Potlapally Rajender Kumar