Two Substituent Nitrogens Bonded Directly To Two Carbons Of The Triazine Ring Patents (Class 544/204)
  • Publication number: 20080306261
    Abstract: Processes comprising: providing an alkanolic reaction mixture, the alkanolic reaction mixture comprising: at least one alkoxycarbonylaminotriazine; at least one carbonic ester; at least one C1-C13-alkanol, which alkanol may further comprise up to two ether-bound oxygen atoms and may further comprise a substituent selected from the group consisting of C1-C4-alkyls and hydroxyls; and at least one alkali metal alkoxide or alkaline earth metal alkoxide; and subjecting the alkanolic reaction mixture to extraction with a polar extractant such that at least a portion of polar/ionic components present in the reaction mixture are removed, wherein the polar extractant is less than entirely miscible with an organic phase of the reaction mixture, to form an alkanolic phase comprising the at least one alkoxycarbonylaminotriazine and a polar phase comprising the polar extractant and the portion of polar/ionic components; and wherein the extraction is carried out with one or more selected from the group consisting of mixer/
    Type: Application
    Filed: June 2, 2006
    Publication date: December 11, 2008
    Applicant: BASF Aktiengesellschaft
    Inventors: Jörg Schneider, Gunter Scherr, Rainer Erhardt, Andreas Eichfelder, Martin Reif, Stefan Hirsch, Georg Sieder, Thomas Holtmann, Jurgen Ciprian, Hermann Ascherl
  • Publication number: 20080293925
    Abstract: For the separation, removal, isolation, purification, characterisation, identification or quantification of plasminogen or a protein that is a plasminogen analogue, an affinity adsorbent is used that is a compound of formula (II) wherein one X is N and the other is N, C—Cl or C—CN; A is a support matrix, optionally linked to the triazine ring by a spacer; Z is O, S or N—R and R is H, C1-6 alkyl, C1-6 hydroxyalkyl, benzyl or &bgr;-phenylethyl; B is an optionally substituted hydrocarbon linkage containing from 1 to 10 carbon atoms; D is H, OH or a primary amino, secondary amino, tertiary amino, quaternary ammonium, imidazole, guanidino or amidino group; or B-D is —CHCOOH—(CH2)3-4—NH2; and q is 2 to 6.
    Type: Application
    Filed: May 9, 2006
    Publication date: November 27, 2008
    Inventors: Jason Richard Betley, Christopher Pearson, Claudia Hildegard Kuhn, Baldev Singh Baines
  • Patent number: 7452883
    Abstract: The invention concerns compounds of general formula (I) wherein: R1, R2, R3, R4, R5 and R6 are as defined in Claim 1. The compounds are useful in the treatment of pathologies related to the insulin-resistance syndrome.
    Type: Grant
    Filed: March 22, 2005
    Date of Patent: November 18, 2008
    Assignee: Merck Sante
    Inventors: Gerard Moinet, Daniel Cravo, Liliane Doare, Micheline Kergoat, Didier Mesangeau
  • Publication number: 20080207876
    Abstract: Compounds of the general formula (I): in which inter alia Q1 represents —NR1R3, —OR1 or —SR1 and Q2 represents —NR2R4, —OR2 or —SR2, and A represents the point of attachment to a support matrix, are useful as protein binding ligands when (a) at least one of R1, R2, R3 and R4 includes an alkyl group —CnH2n+1 in which n is greater than or equal to 7; (b) at least two of R1, R2, R3 and R4 independently include an alkyl group —CnH2n+1 or a cycloalkyl group —CnH2n?1 in which n is greater than or equal to 4; or (c) at least three of R1, R2, R3 and R4 independently include a C1-12 alkyl group substituted by —NR5R6 or aryl.
    Type: Application
    Filed: June 8, 2006
    Publication date: August 28, 2008
    Applicant: PROMETIC BIOSCIENCES LIMITED
    Inventors: Jason Richard Betley, James Christopher Pearson, Helen Rosemary Tatton, Ben Martin Beacom
  • Publication number: 20080207901
    Abstract: The invention relates to a process for preparing free-flowing, pulverulent alkoxycarbonylaminotriazine from an alkanolic reaction mixture which is obtained in the preparation of alkoxycarbonylaminotriazines and comprises at least one alkoxycarbonylaminotriazine, at least one cyclic and/or acyclic carbonic ester, at least one C1-C13-alkanol which optionally comprises one or two oxygen atoms in the form of ether bonds and is optionally substituted by C1-C4-alkyl and/or hydroxyl, and also at least one alkali metal or alkaline earth metal alkoxide, with or without melamine and with or without catalyst, by atomizing and drying the reaction mixture in a spray drier.
    Type: Application
    Filed: May 31, 2006
    Publication date: August 28, 2008
    Applicant: BASF Aktiengesellschaft
    Inventors: Joerg Schneider, Gunter Scherr, Rainer Erhardt, Andreas Eichfelder, Martin Reif, Stefan Hirsch, Georg Sieder, Thomas Holtmann, Jurgen Ciprian, Hermann Ascherl
  • Publication number: 20080118870
    Abstract: There is provided an anti-reflective coating forming composition for lithography comprising a reaction product obtained by reacting a sulfur-containing compound having thiourea structure with a nitrogen-containing compound having two or more nitrogen atoms substituted with a hydroxymethyl group or an alkoxymethyl group in the presence of an acid catalyst and a solvent. The anti-reflective coating obtained from the composition has a high preventive effect for reflected light, causes no intermixing with photoresists, has a higher dry etching rate compared with photoresists and can use in lithography process for manufacturing semiconductor device.
    Type: Application
    Filed: September 27, 2005
    Publication date: May 22, 2008
    Applicant: NISSAN CHEMICAL INDUSTRIES, LTD.
    Inventors: Tomoyuki Enomoto, Yoshiomi Hiroi, Keisuke Nakayama
  • Patent number: 7244732
    Abstract: The present invention provides hydrophobic prodrugs of bases, nucleosides, and nucleotides as well as methods of using the prodrugs as antiviral and anti-cancer chemotherapeutic agents.
    Type: Grant
    Filed: March 31, 2004
    Date of Patent: July 17, 2007
    Assignee: Koronis Pharmaceuticals, Incorporated
    Inventors: Richard Daifuku, Alexander Gall, Dmitri Sergueev, Dina Sologub, Kevin Harris
  • Patent number: 7064125
    Abstract: The invention relates to triazines and the use thereof to inhibit lysophosphatidic acid acyltransferase ? (LPAAT-?) activity. The invention further relates to methods of treating cancer using said triazines. The invention also relates to methods for screening for LPAAT-? activity.
    Type: Grant
    Filed: November 13, 2003
    Date of Patent: June 20, 2006
    Assignee: Cell Therapeutics, Inc.
    Inventors: Baoqing Gong, John Tulinsky, Lynn Bonham, J. Peter Klein, Robert E. Finney, David M. Hollenback, Scott A. Shaffer, Norina M. Tang, Thayer H. White, David W. Leung
  • Patent number: 7038046
    Abstract: There are described triazine derivatives of formula (1), wherein R1 is an unsubstituted or mono- or poly-hydroxy-, C1-C18 alkyl-, C1-C18 alkoxy-, amino-, C1-C5 monoalkylamino- or di-C1-C5 alkylamino-substituted C1-C18 alkyl, C2-C18 alkenyl, C6-C10 aryl or C6-C10 heteroaryl radical; unsubstituted or C1-C5 alkyl-substituted C5-C7 cycloalkyl or C5-C7 cycloalkenyl; —OR?; or —NR?R?; R2 is hydrogen; an unsubstituted or mono- or poly-hydroxy-, C1-C18 alkoxy-, cyano-, amino, C1-C5 monoalkylamino- or di-C1-C5 alkylamino-substituted C1-C18 alkyl, C2-C18 alkenyl; C6-C10 aryl or C6-C10 heteroaryl radical; —OR?; or —NR?R?; or R1 and R2 together form a 5- to 7-membered carbocyclic or heterocyclic ring; A is C1-C5 alkyl; an unsubstituted or hydroxy-, C1-C18 alkyl- or C1-C18 alkoxy-substituted C6-C10 aryl or heteroaryl radical; or a radical of formula (1a); R? and R? are each independently of the other hydrogen; unsubstituted or mono- or poly-hydroxy-, halo-, C1-C18 alkyl-, C1-C18 alkoxy-, amino- or quaternary ammonium group
    Type: Grant
    Filed: August 8, 2002
    Date of Patent: May 2, 2006
    Assignee: Ciba Specialty Chemicals Corporation
    Inventor: Barbara Wagner
  • Patent number: 7034021
    Abstract: The invention concerns compounds of general formula (I) wherein: R1, R2, R3, R4, R5 and R6 are as defined in Claim 1. Said compounds are useful in the treatment of pathologies related to the insulin-resistance syndrome.
    Type: Grant
    Filed: January 25, 2001
    Date of Patent: April 25, 2006
    Assignee: LIPHA
    Inventors: Gérard Moinet, Daniel Cravo, Liliane Doare, Micheline Kergoat, Didier Mesangeau
  • Patent number: 7002011
    Abstract: Compounds of the formula (I) or salts thereof are suitable for preparing active substances from the from the class of the aminotriazines of the formula (IV), for example herbicidal active substances. The compounds (I) can be prepared by chlorinating compounds of the formula (II) where, in the formulae, R1, R2, R3 and X are as defined in claim 1 and A and R have the meaning required in the active substances to be prepared, and they can be reacted with amines of the formula A—NH—R to give the active substances.
    Type: Grant
    Filed: July 2, 1999
    Date of Patent: February 21, 2006
    Assignee: Aventis CropScience GmbH
    Inventors: Jürgen Zindel, Jens Hollander, Klemens Minn, Lothar Willms
  • Patent number: 6867210
    Abstract: This invention relates aryl substituted pyridines, pyrimidines, pyrazines and triazines of Formula I: or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein A1, A2, A3, R1-R4, X and Y are set in the specification. The invention is also directed to the use of compounds of Formula I for the treatment of neuronal damage following global and focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of both acute or chronic pain, as antitinnitus agents, as anticonvulsants, and as antimanic depressants, as local anesthetics, as antiarrhythmics and for the treatment or prevention of diabetic neuropathy.
    Type: Grant
    Filed: March 12, 2001
    Date of Patent: March 15, 2005
    Assignee: Euro-Celtique S.A.
    Inventors: Derk J. Hogenkamp, Phong Nguyen, Bin Shao
  • Publication number: 20040249149
    Abstract: A process is described for preparing alkoxycarbonylaminotriazines by reacting di- or triaminotriazines with dimethyl carbonate in the presence of an alcohol and of an alkali metal or alkaline earth metal methoxide base.
    Type: Application
    Filed: March 31, 2004
    Publication date: December 9, 2004
    Inventors: Joerg Schneider, Gunter Scherr, Hans Schupp, Andreas Eichfelder, Alain Robert, Martin Reif
  • Patent number: 6818768
    Abstract: Mixtures of triazine derivatives free from polyalkylene oxide Mixtures of triazine derivatives free from polyalkylene oxide are produced from 20 to 70 percent by weight of triazine derivatives with hydroxyalkyl amino groups and 80 to 30 percent by weight of triazine derivatives with bis(hydroxyalkyl) imino groups by catalytic reaction of alkylpropylene oxides with triazine derivatives at a melamine derivative/alkylpropylene oxide molar ratio of 1:1.5 to 1:10 in the presence of metal alkyls, metal hydrides, metal alcoholates and/or metal alkylamides as catalysts. The triazine derivative/hydroxy group mixtures free from polyalkylene oxide are particularly suited for producing plastic materials, flame retardants, additives, pharmaceuticals, textile auxiliaries, and paints or finishes.
    Type: Grant
    Filed: July 25, 2002
    Date of Patent: November 16, 2004
    Assignee: Agrolinz Melamin GmbH
    Inventors: Manfred Rätzsch, Martin Burger, Manfred Arnold, Willy Frank
  • Patent number: 6818726
    Abstract: Polymers are prepared from A) 60 to 95 percent by weight of a mixture including A1) 20 to 70 percent by weight of hydroxyalkyl amino triazines and A2) 30 to 80 percent by weight of bis(hydroxyalkyl) amino triazines B) 5 to 40 percent by weight of polyfunctional compounds selected from one or more of B1) polyisocyanates and/or oligomeric polyesters or polyethers with isocyanate end groups, B2) aliphatic dicarboxylic acids, esters, chlorides or anhydrides, or aromatic polybasic acids, esters, chlorides or anhydrides, B3) aliphatic or aromatic diglycidal compounds or triglycidyl compounds, and, optionally, C) 1 to 20 percent by weight of aliphatic, cycloaliphatic or aromatic dihydroxy compounds, polyalkylene glycols and aliphatic aldehydes.
    Type: Grant
    Filed: July 25, 2002
    Date of Patent: November 16, 2004
    Assignee: Agrolinz Melamin GmbH
    Inventors: Manfred Rätzsch, Martin Burger, Manfred Arnold, Willy Frank
  • Patent number: 6803349
    Abstract: A heterocyclic ring-containing compound represented by the following formula (1). In the formula, D represents a heterocyclic ring residue having a 5- to 7-membered ring structure and substituted with (m+n) of substituents, X represents a divalent linking group consisting of a single bond, NR3 group (R3 represents a hydrogen atom or an alkyl group having 1-30 carbon atoms), an oxygen atom, a sulfur atom, a carbonyl group, a sulfonyl group or a combination thereof, R1 represents an alkyl group, an alkenyl group, an alkynyl group, an aryl group or a heterocyclic group, which may be substituted or unsubstituted, R2 represents a halogen atom, a hydroxy group, an unsubstituted amino group, a mercapto group, a cyano group, a sulfide group, a carboxy group or salt thereof, a sulfo group or salt thereof, a hydroxyamino group, a ureido group or a urethane group, m represents 1 or 2, and n represents an integer of 1 or larger.
    Type: Grant
    Filed: September 25, 2002
    Date of Patent: October 12, 2004
    Assignee: Fuji Photo Film Co., Ltd.
    Inventors: Masayuki Negoro, Kensuke Morita, Ken Kawata
  • Patent number: 6727251
    Abstract: This invention describes novel pyrazole compounds of formula II: wherein Z1 is nitrogen or CR8; Q is —S—, —O—, —N(R4)—, or —CH(R6)—; R1 is T-Ring D, wherein Ring D is a 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl; and Ry, R2, and R2′ are as described in the specification. The compounds are useful as protein kinase inhibitors, especially as inhibitors of Aurora-2 and GSK-3, for treating diseases such as cancer, diabetes and Alzheimer's disease.
    Type: Grant
    Filed: December 20, 2001
    Date of Patent: April 27, 2004
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: David Bebbington, Jean-Damien Charrier, Julian Golec, Francoise Pierard
  • Publication number: 20040019050
    Abstract: This invention is directed to triazine derivatives which are selective antagonists for a NPY (Y5) receptor. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of the compound of the invention and a pharmaceutically acceptable carrier. This invention provides a pharmaceutical composition made by combining a therapeutically effective amount of the compound of this invention and a pharmaceutically acceptable carrier. This invention further provides a process for making a pharmaceutical composition comprising combining a therapeutically effective amount of the compound of the invention and a pharmaceutically acceptable carrier.
    Type: Application
    Filed: April 22, 2003
    Publication date: January 29, 2004
    Applicant: Synaptic Pharmaceutical Corporation
    Inventors: Mohammad R. Marzabadi, Stewart A. Nobel, Mahesh N. Desai
  • Patent number: 6632305
    Abstract: The present invention includes a precursor compound pertaining to a 1,2,4-Triazolo[4,3-a][1,3,5]Triazine compound, particularly a 1,2,4-Triazolo[4,3-a][1,3,5]Triazine-3,5,7-Triamine, and novel fused ring structures such as triazolyl-tetrazinyl-aminotriazine compounds, and complexes and salts thereof, and other such chemical structures.
    Type: Grant
    Filed: June 14, 2002
    Date of Patent: October 14, 2003
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventors: William M. Koppes, Michael E. Sitzmann
  • Publication number: 20030186817
    Abstract: Substituted 2,4-diamino-1,3,5-triazines of the formula I and salts thereof, processes for their preparation and their use as herbicides and plant growth regulators are described.
    Type: Application
    Filed: June 25, 1999
    Publication date: October 2, 2003
    Inventors: JENS HOLLANDER, LOTHAR WILLMS, JURGEN ZINDEL, KLEMENS MINN, WOLFGANG GIENCKE, HERMANN BIERINGER, CHRISTOPHER ROSINGER, THOMAS AULER
  • Publication number: 20030166002
    Abstract: Triazine linkers can be used as universal small molecule chips for functional proteomics and sensors. These compounds are prepared by making a first building block by adding a first amine by reductive amination of triazine, making a second building block by adding a second amine to cyanuric chloride, and combining the first and second building blocks by aminating the first building block onto one of the chloride positions of the second building block.
    Type: Application
    Filed: October 9, 2002
    Publication date: September 4, 2003
    Inventors: Young-Tae Chang, Ho-Sang Moon, Sonya M. Khersonsky
  • Publication number: 20030139416
    Abstract: The invention encompasses compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions, uses and methods for prophylaxis and treatment of cancer and polycystic kidney disease.
    Type: Application
    Filed: April 10, 2002
    Publication date: July 24, 2003
    Inventors: John L. Buchanan, Joseph L. Kim, Perry M. Novak, Joseph J. Nunes, Vinod F. Patel
  • Publication number: 20030100758
    Abstract: The process to recover both melamine and oxyaminotriazines (OAT) from the mother liquors of melamine crystallisation comprising the following steps: a) addition to a melamine and OAT containing aqueous solution at high temperature of an alkaline agent until the solution pH reach a value equal or higher than 11; b) most of melamine crystallisation by solution cooling; c) separation and recovery of precipitated melamine; d) acidification of the obtained solution, after precipitated melamine separation, in order to reach a pH of about 7; e) the suspension obtained in d) above after precipitated melamine recovery, is subject to filtration according to tangential filtration technique obtaining a clear permeate which contains as a solution all melamine which did not precipitate in step b) and a retentate comprising of OAT dispersion; f) OAT deprived mother liquors from e) are recycled to row melamine solution preparation step; in such a way almost the total amount of melamine, which did not precipitate in step b),
    Type: Application
    Filed: October 17, 2002
    Publication date: May 29, 2003
    Inventors: Sergio Noe, Massimo Parmegiani, Giovanni Morello
  • Patent number: 6555683
    Abstract: In the proposed condensation product based on amino-s-triazines with at least two amino groups, formaldehyde and sulphite, the molar ratio of amino-s-triazine, formaldehyde and sulphite is 1:2.5-6.0:1.51-2.0 and the formiate content is less than 0.3 wt %. The condensation product is obtained by a) heating amino-s-triazine, formaldehyde and a sulphite in the molar ratio 1:2.5-6.0:1.51-2.0 in an aqueous solution at a temperature of 60-90° C. and a pH level of between 9.0 and 13.0 until the sulphite can no longer be detected; b) continuing the condensation at a pH level of between 3.0 and 6.5 and a temperature of 60-80° C. until the condensation product has a viscosity of 5-50 mm/s at 80° C.; and c) adjusting the pH level of the condensation product to 7.5-12.0 or carrying out thermal secondary treatment at a pH level of >10.0 and a temperature of 60-100° C. The product can be used as an additive for inorganic binders such as cement.
    Type: Grant
    Filed: September 29, 1997
    Date of Patent: April 29, 2003
    Assignee: SKW Polymers GmbH
    Inventors: Josef Weichmann, Aloisia Stadler, Alfred Kern
  • Publication number: 20030050474
    Abstract: Mixtures of triazine derivatives free from polyalkylene oxide are produced from 20 to 70 percent by weight of triazine derivatives with hydroxyalkyl amino groups and 80 to 30 percent by weight of triazine derivatives with bis(hydroxyalkyl) imino groups by catalytic reaction of alkylpropylene oxides with triazine derivatives at a melamine derivative/alkylpropylene oxide molar ratio of 1:1.
    Type: Application
    Filed: July 25, 2002
    Publication date: March 13, 2003
    Applicant: Agrolinz Melamin GmbH
    Inventors: Manfred Ratzsch, Martin Burger, Manfred Arnold, Willy Frank
  • Patent number: 6506898
    Abstract: Provided is a process for preparing an at least bis-carbamate functional 1,3,5-triazine by contacting an at least diamino-1,3,5-triazine, an acyclic organic carbonate and a base, as well as certain novel compositions producible thereby. Also provided are substantially halogen contamination free crosslinker compositions comprising the products obtainable by the process, and curable compositions based upon these crosslinkers.
    Type: Grant
    Filed: May 25, 1995
    Date of Patent: January 14, 2003
    Assignee: Cytec Technology Corp.
    Inventors: Lawrence A. Flood, Ram B. Gupta, Revathi Iyengar, David A. Ley, Vankatarao K. Pai
  • Patent number: 6479492
    Abstract: Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.
    Type: Grant
    Filed: January 21, 2000
    Date of Patent: November 12, 2002
    Assignee: Elan Pharmaceuticals, Inc.
    Inventors: Andrei W. Konradi, Michael A. Pleiss, Eugene D. Thorsett, Susan Ashwell, Dimitrios Sarantakis, Gregory S. Welmaker, Anthony Kreft, Christopher Semko, Robert Warren Sullivan, Christopher Joseph Soares, Kiev Sui Ly, Christine M. Tarby
  • Publication number: 20020158352
    Abstract: The present invention relates to a triazine type monomer, and more particularly, to a 1,3,5-triazine type monomer characterized by having at least one amine group and at least two sulfur atoms, which can be used in manufacturing transparent optical resins having excellent refractive index, surface hardness and absorbance as well as an improved workability and the ability to control a wide range of refractive index according to the change in composition by the monomer itself at room temperature or by polymerizing the monomer with a comonomer in the presence of an organic solvent or an initiator.
    Type: Application
    Filed: August 10, 2001
    Publication date: October 31, 2002
    Inventor: Eun Kyoung Kim
  • Publication number: 20020147181
    Abstract: This invention concerns the compounds of formula 1
    Type: Application
    Filed: November 15, 2001
    Publication date: October 10, 2002
    Inventors: Paul A.J. Janssen, Jan Heeres, Henri E.L. Moereels, Michael Joseph Kukla, Donald W. Ludovici
  • Patent number: 6448398
    Abstract: A process is disclosed for preparing acid amides, including isocyanate-functional 1,3,5-triazines and isocyanate-based 1,3,5 triazine derivatives, from the reaction of (Si, Ge or Sn substituted amino)-1,3,5 triazines and acid halides.
    Type: Grant
    Filed: October 18, 1994
    Date of Patent: September 10, 2002
    Assignee: Cytec Technology Corp.
    Inventor: William Elliott Bay
  • Patent number: 6407220
    Abstract: The present invention provides reactive formazan dyestuffs of the general formula (I), Wherein A, B, D, Me, Q, R, and Z are defined in this document. The dyes according to the invention are distinguished by high fixation and a very good build-up. They are distinguished also by a low substantivity and a high exhaustion, and they have fiber-reactive properties and are very highly suitable for dyeing and printing of materials containing either cellulose fibers.
    Type: Grant
    Filed: December 14, 2001
    Date of Patent: June 18, 2002
    Assignee: Everlight USA, Inc.
    Inventors: Huei Ching Huang, Wen-Jang Chen
  • Patent number: 6372743
    Abstract: Disclosed are compounds of the formula: where R1, R2, R3, R4, R5, R6, and X are defined herein. These compounds are selective modulators of NPY1 receptors. These compounds are useful in the treatment of a number of CNS disorders, metabolic disorders, and peripheral disorders, particularly eating disorders and hypertension. Methods of treatment of such disorders and well as packaged pharmaceutical compositions are also provided. Compounds of the invention are also useful as probes for the localization of NPY1 receptors and as standards in assays for NPY1 receptor binding. Methods of using the compounds in receptor localization studies are given.
    Type: Grant
    Filed: September 29, 2000
    Date of Patent: April 16, 2002
    Assignees: Neurogen Corporation, Pfizer Inc.
    Inventors: James W. Darrow, Stephane De Lombaert, Charles Blum, Jennifer Tran, Mark Giangiordano, David Andrew Griffith, Philip Albert Carpino
  • Patent number: 6350872
    Abstract: Quaternary ammonium compounds having at least two fiber reactive sites and at least two dye reactive sites, and processes for making and using the same are disclosed. The compounds of the invention can advantageously be used in a cellulosic fabric pretreatment process to allow anionic dyeing without requiring salt to exhaust or drive the dye into the cellulosic fiber.
    Type: Grant
    Filed: October 28, 1998
    Date of Patent: February 26, 2002
    Assignee: The Virkler Company
    Inventors: Howard E. Virkler, D. M. Lewis, Peter J. Broadbent
  • Patent number: 6307046
    Abstract: The present invention provides a method for modifying melamine derivatives that can produce N-substituted melamine derivatives by introducing a substituent group to melamine or N-substituted melamine derivatives. The method is characterized by heating melamine or an N-substituted melamine derivative and an alcohol in the presence of a mixed catalyst comprising a hydrogenation catalyst and a dehydrogenation catalyst and hydrogen to allow reaction or heating melamine or an N-substituted melamine derivative and an alcohol in the presence of a hydrogenation catalyst and hydrogen with addition/coexistence of a metal to allow reaction. The compound groups obtained by introducing a substituent group to the amino group of melamine derivative with an alcohol by the method of the present invention can be used widely as intermediates of fine chemicals such as various agricultural chemicals, medicines, dyes, paints, etc. and as various resin materials and flame retardant materials.
    Type: Grant
    Filed: July 31, 2000
    Date of Patent: October 23, 2001
    Assignee: Nissan Chemical Industries, Ltd.
    Inventors: Norio Tanaka, Hiroyuki Kousaka, Yasuyuki Nakajima, Kouichi Masahashi, Takashi Kitabayashi
  • Patent number: 6297299
    Abstract: Compounds of the formula (I) in which the polydispersity {overscore (M)}w/{overscore (M)}n is 1; n is 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14 or 15; the radicals R1 are for example hydrogen or C1-C8alkyl; R2 is for example C2-C12alkylene; the radicals A are independently of one another —OR3, —N(R4)(R5) or a group of the R3, R4 and R5, which are identical or different, are for example hydrogen or C1-C18alkyl, or —N(R4)(R5) is additionally a group of the formula with Y being —O—, —CH2—, —CH2CH2— or >N—CH3; X is —O— or >N—R6; R6 is for example hydrogen or C1-C18alkyl; R is preferably a group of the formula and the radicals B have independently of one another one of the definitions given for A; with the proviso that in the individual recurrent units of the formula (I), each of the radicals B, R, R1 and R2 has the same or a different meaning, are useful as ligh
    Type: Grant
    Filed: November 4, 1999
    Date of Patent: October 2, 2001
    Assignee: Ciba Specialty Chemicals Corp.
    Inventors: Valerio Borzatta, Fabrizio Guizzardi
  • Patent number: 6288226
    Abstract: Provided is a process for preparing an at least bis-carbamate functional 1,3,5-triazine by contacting an at least diamino-1,3,5-triazine, an acyclic organic carbonate and a base, as well as certain novel compositions producible thereby. Also provided are substantially halogen contamination free crosslinker compositions comprising the products obtainable by the process, and curable compositions based upon these crosslinkers.
    Type: Grant
    Filed: October 6, 1998
    Date of Patent: September 11, 2001
    Assignee: Cytec Technology Corporation
    Inventors: Lawrence A. Flood, Ram B. Gupta, Revathi Iyengar, David A. Ley, Venkatarao K. Pai
  • Patent number: 6204381
    Abstract: Disclosed is the preparation of 1,3,5-triazine carbamates which are suitable for use as crosslinking agents in curable compositions, particularly in coating compositions which are capable of curing at relatively low temperatures without releasing formaldehyde during cure. The process includes the step of contacting a 1,3,5-triazine derivative having cyanate-displaceable leaving groups (i.e. cyanuric chloride), a cyanate-containing reagent (i.e. potassium cyanate), and an isocyanate-reactive compound such as an alcohol, in the presence of a polar solvent or in the presence of a non-polar solvent in combination with a phase transfer catalyst.
    Type: Grant
    Filed: May 17, 1999
    Date of Patent: March 20, 2001
    Assignee: Cytec Technology Corp.
    Inventor: Hong Zhao
  • Patent number: 6204382
    Abstract: The present invention relates generally to carboxylated amino-1,3,5-triazines and the preparation thereof via carboxylation of amino-1,3,5-triazines with carbon dioxide and a base. These carboxylated amino-1,3,5-triazines find use, for example, as intermediates in the production of other useful amino-1,3,5-triazine derivatives, and particularly carbamate and isocyanate functional 1,3,5-triazines. The present invention also relates to the preparation of such carbamate and isocyanate functional 1,3,5-triazines.
    Type: Grant
    Filed: August 5, 1994
    Date of Patent: March 20, 2001
    Assignee: Cytec Technology Corp.
    Inventors: Lawrence Allen Flood, Ram Baboo Gupta
  • Patent number: 6130332
    Abstract: The object of the present invention is to provide a method for producing substituted-1,3,5-triazine derivatives at high yield, in which at least one of carbon atoms in the ring thereof is substituted by a secondary amine group having at leat one of alkyl groups. The method of the present invention is a method for alkylation of 1,3,5-triazine derivatives, characterized by reacting 1,3,5-triazine derivatives (melamines, melamine derivatives, various kinds of guanaminde derivatives, etc.) which has at least one or more amino groups or mono-substituted amino groups on carbon atom of the ring thereof, with aldehydes or ketones alcohols in the presence of a catalyst of a metal of group VII and/or group VIII in the periodic table and a hydrogen-containing gas to alkylate said at least one of amino groups or mono-substituted amino groups.
    Type: Grant
    Filed: February 7, 1997
    Date of Patent: October 10, 2000
    Assignee: Nissan Chemical Industries, Ltd.
    Inventors: Norio Tanaka, Kenichi Mizusawa, Makoto Ishikawa, Yasuo Fukue, Isao Hashiba, Yoshihisa Watanabe
  • Patent number: 6069114
    Abstract: Compounds of the formula (I) and their salts ##STR1## in which R.sup.1 to R.sup.6, Y.sup.1, to Y.sup.2, Y.sup.3, m and n are as defined in claim 1 are suitable as herbicides and plant growth regulators. They can be prepared analogously to known processes using intermediates of the formula (V) (cf. claim 6).
    Type: Grant
    Filed: February 25, 1997
    Date of Patent: May 30, 2000
    Assignee: Hoechst Schering AgrEvo GmbH
    Inventors: Klaus Lorenz, Klemens Minn, Lothar Willms, Klaus Bauer, Hermann Bieringer, Christopher Rosinger
  • Patent number: 6063922
    Abstract: Provided is a novel carbamate functional 1,3,5-triazine of the general formula ##STR1## wherein Z' is selected from the group consisting of hydrogen, hydrocarbyl, and a group represented by the formula NHQ',each Q' is independently selected from the group consisting of a hydrocarbyl, a hydrocarbyloxy hydrocarbyl and a group represented by the formula COOY, with the proviso that at least two of the Q' groups are COOY, andeach Y is independently selected from the group consisting of a hydrocarbyl group and a hydrocarbyloxy hydrocarbyl ether group, with the proviso that at least one Y group is a hydrocarbyloxy hydrocarbyl ether group. These carbamate functional 1,3,5-triazines find use, for example, as crosslinkers or reactive modifiers in curable compositions.
    Type: Grant
    Filed: March 13, 1997
    Date of Patent: May 16, 2000
    Assignee: Cytec Technology Corp.
    Inventors: Lawrence A. Flood, Ram B. Gupta, Revathi Iyengar, David A. Ley, Vankatarao K. Pai
  • Patent number: 6046304
    Abstract: Compounds of the formula (I) ##STR1## in which the polydispersity Mw/Mn is 1; n is 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14 or 15; the radicals R.sub.1 are for example hydrogen or C.sub.1 -C.sub.8 alkyl; R.sub.2 is for example C.sub.2 -C.sub.12 alkylene; the radicals A are independently of one another --OR.sub.3, --N(R.sub.4)(R.sub.5) or a group of the formula ##STR2## R.sub.3, R.sub.4 and R.sub.5, which are identical or different, are for example hydrogen or C.sub.1 -C.sub.18 alkyl,or --N(R.sub.4)(R.sub.5) is additionally a group of the formula ##STR3## with Y being --O--, --CH.sub.2 --, --CH.sub.2 CH.sub.2 -- or >N--CH.sub.3 ; X is --O-- or >N--R.sub.6 ; R.sub.6 is for example hydrogen or C.sub.1 -C.sub.18 alkyl; R is preferably a group of the formula ##STR4## and the radicals B have independently of one another one of the definitions given for A; with the proviso that in the individual recurrent units of the formula (I), each of the radicals B, R, R.sub.1 and R.sub.
    Type: Grant
    Filed: November 25, 1996
    Date of Patent: April 4, 2000
    Assignee: Ciba Specialty Chemicals Corporation
    Inventors: Valerio Borzatta, Fabrizio Guizzardi
  • Patent number: 5998306
    Abstract: The compounds of the s-triazine series of formula I ##STR1## wherein the symbols R.sub.1, R.sub.2, R.sub.3, X and n possess the significances given in claim 1, are eminently suitable, when applied to textile material, as UV-absorbers, as resist agents for anionic dyes, and as stain blockers.
    Type: Grant
    Filed: May 13, 1998
    Date of Patent: December 7, 1999
    Assignee: Clariant Finance (BVI) Limited
    Inventor: Jean Luc Mura
  • Patent number: 5968482
    Abstract: The invention relates to the use of .alpha.-hydroxyketoalkyl derivatives as light protection filters for cosmetic or pharmaceutical products, the .alpha.-hydroxyketoalkyl group being linked, if appropriate via a spacer, to a chromophoric group which has an absorption maximum in a wavelength range of between 280 and 400 nm and has a conjugated .pi.-electron system of at least 8 .pi.-electrons, and to new .alpha.-hydroxyalkyl derivatives, processes for their preparation and pharmaceutical and cosmetic formulations comprising these derivatives as light protection substances.
    Type: Grant
    Filed: September 20, 1996
    Date of Patent: October 19, 1999
    Assignee: Merck Patent Gesellschaft MIT Beschrankter Haftung
    Inventors: Roland Martin, Ingeborg Stein, Ulrich Heywang, Michael Schwarz, Thekla Kurz
  • Patent number: 5968208
    Abstract: A process for coloration of a substrate comprising applying thereto at a pH above 7 a water-soluble reactive dye comprising at least three chromophoric groups linked to a polyamine. Also claimed are dyes suitable for use in the process.
    Type: Grant
    Filed: June 8, 1998
    Date of Patent: October 19, 1999
    Assignee: Zeneca Limited
    Inventor: John Anthony Taylor
  • Patent number: 5931975
    Abstract: Dyes of the formula ##STR1## in which A.sub.1 and A.sub.2 independently of one another are the radical of a monoazo, polyazo, metal complex azo, anthraquinone, phthalocyanine, formazan, azomethine, dioxazine, phenazine, stilbene, triphenylmethane, xanthene, thioxanthone, nitroaryl, naphthoquinone, pyrenequinone or perylenetetracarbimide dye,R.sub.1, R.sub.2, R.sub.3 and R.sub.4 independently of one another are hydrogen or substituted or unsubstituted C.sub.1 -C.sub.4 alkyl,Y.sub.1 and Y.sub.2 independently of one another are halogen, carboxypyridinium, substituted or unsubstituted amino or a heterocyclic radical bonded via a nitrogen atom andn is a number from 1 to 7,are particularly suitable for dyeing or printing fiber materials containing hydroxyl groups or nitrogen. Dyeings with good fastness properties are obtained with a high dyeing yield.
    Type: Grant
    Filed: October 16, 1997
    Date of Patent: August 3, 1999
    Assignee: Ciba Specialty Chemicals Corporation
    Inventors: Bernhard Muller, Patric Nowack
  • Patent number: 5922122
    Abstract: A composition containing an organic pigment and a compound having the formula (I): ##STR1## in which R.sup.1 is a group having the formula (II): ##STR2## in which R.sup.4 and R.sup.5 represent hydrogen or alkyl, or R.sup.4 and R.sup.5 are bonded to each other to form a ring together with a nitrogen atom, X represents alkylene or alkyleneoxyalkylene, and Y represents --O--, --S-- or a group represented by --NR.sup.6 -- wherein R.sup.6 is hydrogen or lower alkyl; and R.sup.2 and R.sup.3 represent a group having the formula (II), alkyl, aralkyl, aryl, alkoxy, aralkyloxy, aryloxy, alkylamino, arylamino or a halogen atom. A photosensitive colored composition is made of the composition, a polymer having acidic group, a photopolymerizable monomer and a photopolymerization initiator.
    Type: Grant
    Filed: July 29, 1997
    Date of Patent: July 13, 1999
    Assignee: Fuji Photo Film Co., Ltd.
    Inventors: Akihiko Takeda, Takekatsu Sugiyama
  • Patent number: 5885993
    Abstract: The invention relates to a therapeutic drug for pancreatitis which comprises a compound of the following general formula ?I! or a salt thereof, or a solvate thereof. ##STR1## In the above formula, R.sup.1 and R.sup.2 may be the same or different and each represents hydrogen, alkyl which may be substituted, aralkyl, arylalkenyl, or aryl, or R.sup.1 and R.sup.2 taken together with the adjacent N atom, i.e. in the form of NR.sup.1 R.sup.2, represent a 4- through 8-membered cyclic amino group, which cyclic amino group may contain nitrogen, oxygen, or sulfur as a ring member in addition to the above-mentioned N atom and may be further substituted.
    Type: Grant
    Filed: September 9, 1997
    Date of Patent: March 23, 1999
    Assignee: Nippon Shinyaku Company, Limited
    Inventor: Fusao Ueda
  • Patent number: 5885935
    Abstract: Herbicidal sulfonamides of the formula: ##STR1## and salts thereof, where: A represents a substituted or unsubstituted benzene ring, or a 5- or 6-membered substituted or unsubstituted heteroaromatic ring; Q is --O--, --S-- or a group --CXX'--; X and X', which may be the same or different, are each hydrogen, halogen, cyano, an optionally-substituted alkyl group, or a group --OR.sup.a, --SR.sup.a, or --COR.sup.b ; or one of X and X' represents hydroxy and the other is as defined above; or X and X' together represent .dbd.O or .dbd.S; R.sup.a is an optionally-substituted alkyl, aryl or acyl group; R.sup.b is an optionally-substituted alkyl or aryl group, or a group --OR.sup.c or --NR.sup.c R.sup.d ; R.sup.c and R.sup.d, which may be the same or different, are each hydrogen, or an optionally-substituted alkyl or aryl group; Y is nitrogen or a group CR.sup.9 ; R.sup.1 is an optionally-substituted alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heterocyclyl, benzoheterocyclyl or amino group; R.sup.
    Type: Grant
    Filed: June 21, 1996
    Date of Patent: March 23, 1999
    Assignee: Agrevo UK Limited
    Inventors: Peter Stuart Gates, Graham Peter Jones, David Edward Saunders
  • Patent number: 5807929
    Abstract: At least bis-imido 1,3,5-triazines and processes of preparing the same are disclosed. Also disclosed are prepolymers having at least bis-imido functionality and curable compositions comprising at least bis-imido 1,3,5-triazines or prepolymers thereof in combination with active hydrogen and/or epoxy functional materials. The at least bis-imido 1,3,5-triazines and prepolymers may be advantageously employed as crosslinking agents which crosslink by a ring opening reaction that eliminates the release of volatile organic compounds.
    Type: Grant
    Filed: February 28, 1997
    Date of Patent: September 15, 1998
    Assignee: Cytec Technology Corp.
    Inventors: Lon-Tang Wilson Lin, Robert G. Lees, William F. Jacobs, III, Subban Ramesh