Additional Ring Containing Patents (Class 544/211)
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Patent number: 7858799Abstract: An ionic organic compound having a repeating unit of formula (I) can be synthesized easily from a readily available organic compound through a small number of reaction steps, can be produced without any purification technique such as chromatography, and can be used in a quite small amount for gelation of water or an ionic liquid without any other auxiliary solvent: [-(A-B-C)n-]•m(X)??(I) wherein A represents a group having a quaternary ammonium cation which is formed from a heterocyclic compound having at least one nitrogen atom; B represents a functional group, which may have a substituent, selected from amide, urea, urethane and peptide groups; C represents a divalent hydrocarbon group, which may have a substituent, capable of linking between A and B; X represents an anion; n represents the number of repeating units; m represents the total number of anions; and n and m are the same integer.Type: GrantFiled: January 30, 2006Date of Patent: December 28, 2010Assignee: National Institute of Advanced Industrial Science and TechnologyInventors: Masaru Yoshida, Nagatoshi Koumura, Nobuyuki Tamaoki, Hajime Kawanami, Hajime Matsumoto, Said Kazaoui, Nobutsugu Minami
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Publication number: 20100285963Abstract: The invention relates to substituted fluoroalkoxyphenylsulfonylureas of the general formula (I) in which n, A, R1, R2, R3 and R4 are as defined in the description, to their use as plant treatment agents, in particular as herbicides and fungicides, and to a process and intermediates for their preparation.Type: ApplicationFiled: July 16, 2010Publication date: November 11, 2010Inventors: Klaus-Helmut Muller, Ernst-Rudolf Gesing, Joachim Kluth, Mark Wilhelm Drewes, Peter Dahmen, Dieter Feucht, Rolf Pontzen, Ulrike Wachendorff-Neumann
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Publication number: 20100285964Abstract: The present invention relates to salts of 2-iodo-N-[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)carbamoyl]benzenesulfonamide, to processes for their preparation and to their use as herbicides, in particular as herbicides for the selective control of unwanted harmful plants in crops of useful plants, permanent crops or on non-crop land, and also as plant growth regulators, on their own or with safeners and/or in combination with other herbicides, to their use for controlling unwanted harmful plants (such as, for example, broad-leaved/weed grasses) in specific crop plants or as crop protection regulators, for simultaneous and/or sequential application, either as a readymix or as a tank mix.Type: ApplicationFiled: October 22, 2008Publication date: November 11, 2010Applicant: BayerCropScience AGInventors: Christian Waldraff, Klaus-Helmut Mueller, Ernst Rudolf Gesing, Jan Dittgen, Dieter Feucht, Hansjoerg Kraehmer, Jeffrey Martin Hills, Georg Bonfig-Picard, Martin Hess, Dominique Schreiber, Hugh Christopher Rosinger
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Publication number: 20100267945Abstract: A compound of the formula (I): a pharmaceutically acceptable salt or solvate thereof, where R1 is optionally substituted lower alkyl, Y is —S(O)2—, R2 is hydrogen or optionally substituted lower alkyl, R7 is hydrogen or optionally substituted lower alkyl, X is a group of the formula: where R5 and R6 are each independently hydrogen, a group of the formula: is optionally substituted cycloalkylene, p is 0, and q is 1 or 2, Z is optionally substituted carbocyclyl or optionally substituted heterocyclyl, and provided that a compound wherein Z is fused heterocyclyl consisting of three rings or optionally substituted pyrimidinyl is excluded.Type: ApplicationFiled: June 25, 2010Publication date: October 21, 2010Applicant: Shionogi & Co., Ltd.Inventors: Takayuki Okuno, Naoki Kouyama, Masahiro Sakagami
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Publication number: 20100258790Abstract: The present invention relates to an organic light-emitting diode comprising at least one diphenylaminobis(phenoxy)triazine or at least one bis(diphenylamino)phenoxytriazine compound, to a light-emitting layer comprising at least one diphenylamino-bis(phenoxy)triazine or at least one bis(diphenylamino)phenoxytriazine compound, to the use of the aforementioned compounds as a matrix material, hole/exciton blocker material, electron/exciton blocker material, hole injection material, electron injection material, hole conductor material and/or electron conductor material, and to a device selected from the group consisting of stationary visual display units, mobile visual display units and illumination units comprising at least one inventive organic light-emitting diode.Type: ApplicationFiled: October 21, 2008Publication date: October 14, 2010Applicant: BASF SEInventors: Evelyn Fuchs, Nicolle Langer, Christian Lennartz, Peter Strohriegl, Michael Rothmann
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Publication number: 20100251932Abstract: A method of modifying a particle that includes reacting a reactive compound having an X—[Y]n reactive group with a secondary compound N—S-ZM to form a substituted reactive intermediate [Y]a—X—(N—S-ZM)b, and reacting the particle with the substituted reactive intermediate [Y]a—X—(N—S-ZM)b to attach the substituted reactive intermediate to the surface of the particle to form a surface modified particle. The particle may comprise at least one of a dye particle, an inorganic pigment particle, an additive, or a combination thereof. X may be a sulfonyl, phosphoryl, or 1,3,5-triazinyl group. Y may be a halogen leaving group. N may be a nucleophilic group. S may be an organic group. ZM may be an ionizable end group. Also, n is an integer between 1 and 3, b is an integer between 1 and 3, and a=n?b. When n is equal to or greater than b, and wherein if b is 2 or 3, each N—S-ZM can be the same or different.Type: ApplicationFiled: April 7, 2010Publication date: October 7, 2010Inventors: Puthalath K. Sujeeth, John P. Kane, Martial Blanc, Pascal Gruffel, Gilles Dolivo, Marco Ribezzo, Daniel A. Ouellette, Carol D. Landi, Rahul A. Ranade, Mark Ulrich
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Publication number: 20100222352Abstract: The present invention relates to compounds according to the formula I: Where Ra is H or an optionally OH-substituted C1-C3 alkyl; R1 is OR1, an optionally substituted C4-12 carbocyclic group which may be saturated or unsaturated (including aromatic) or an optionally substituted heterocyclic group; R1 is an optionally substituted C1-C14 hydrocarbyl group or an optionally substituted heterocyclic group; R2, R3 and R4 are each independently H, an optionally substituted C1-C4 alkyl group (preferably CH3, CH2CH3 or CF3), halogen (preferably F, Cl, Br), OR, CN, NO2, a C1-C6 thioether, a C1-C6 thioester group, an optionally substituted CO2R group, an optionally substituted COR group or an optionally substituted OCOR group (preferably R4 is H); R is H or an optionally substituted C1-C6 alkyl group; RHET is an optionally substituted heterocyclic group; and pharmaceutically acceptable salts, solvates or polymorphs thereof.Type: ApplicationFiled: September 25, 2006Publication date: September 2, 2010Applicant: YALE UNIVERSITYInventors: William L. Jorgensen, Juliana Ruiz-Caro, Andrew D. Hamilton
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Publication number: 20100222342Abstract: Pyrrole pyrazole compounds of formula I, compositions including these compounds and methods of their use are provided. Preferred compounds of formula I have activity as protein kinase inhibitors, including as inhibitors of PAK4.Type: ApplicationFiled: December 28, 2005Publication date: September 2, 2010Inventors: Junhu Zhang, Chuangxing Guo, Djamal Bouzida, Liming Dong, Haitao Li, Joseph Timothy Marakovits, Anle Yang, Yufeng Hong
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Publication number: 20100093731Abstract: The invention relates to compounds of formula wherein R1, R2, R3, R4, and Ar are as defined in the specification and claims, or to pharmaceutically active acid addition salts of such compounds. Compounds of formula I are modulators for amyloid beta and may be useful for the treatment or prevention of a disease associated with the deposition of ?-amyloid in the brain, in particular Alzheimer's disease, and other diseases such as cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, Dutch-type (HCHWA-D), multi-infarct dementia, dementia pugilistica and Down syndrome.Type: ApplicationFiled: October 2, 2009Publication date: April 15, 2010Inventors: Erwin Goetschi, Synese Jolidon, Thomas Luebbers
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Patent number: 7648986Abstract: Disclosed are compounds and derivatives thereof their synthesis, and their use as Rho-kinase inhibitors. These compounds of the present invention are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.Type: GrantFiled: April 9, 2007Date of Patent: January 19, 2010Assignee: Bayer Healthcare LLCInventors: Dhanapalan Nagarathnam, Uday Khire, Davoud Asgari, Jianxing Shao, Xiao-Gao Liu, Chunguang Wang, Barry Hart, Olaf Weber, Mark Lynch, Lei Zhang, Lei Wang
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Patent number: 7642303Abstract: Thermoplastic composition and articles containing UV absorbers that protect the articles contents from harmful UV radiation are disclosed as well as methods for making the thermoplastic articles and methods for using the articles to contain and protect materials sensitive to UV radiation. The UV absorbers contain oxazolone and/or azine functional groups that absorb UV radiation and prevent its transmission into the article. Many of the compounds are novel compositions of matter. The generally clear thermoplastic articles of this disclosure are particularly useful for containing a variety of UV sensitive consumer products that would otherwise have to be packaged in opaque containers.Type: GrantFiled: October 13, 2005Date of Patent: January 5, 2010Inventors: Thomas L. Shakely, James John Krutak
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Patent number: 7608618Abstract: Compounds of the formula wherein: Y? is O or S, W? is optionally substituted, Z? is selected from the group consisting of wherein Q? is OR7 and R7 is C1-3alkyleneC3-8heterocycloalkyl useful in the treatment of diseases and conditions related to DNA damage or lesions in DNA replication are disclosed. Methods of making the compounds, and their use as therapeutic agents, for example, in treating cancer and other diseases characterized by defects in DNA replication, chromosome segregation, or cell division also are disclosed.Type: GrantFiled: April 27, 2005Date of Patent: October 27, 2009Assignee: Icos CorporationInventors: Edward A. Kesicki, John Joseph Gaudino, Adam Wade Cook, Scott Douglas Cowen, Laurence Edward Burgess
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Publication number: 20090247524Abstract: Compounds represented by formula (1) shown below, pharmaceutically acceptable salts thereof, and pharmaceutical compositions comprising such compounds are provided.Type: ApplicationFiled: May 25, 2007Publication date: October 1, 2009Applicant: CHUGAI SEIYAKU KABUSHIKI KAISHAInventors: Takuo Tsukuda, Ken-ichi Kawasaki, Susumu Komiyama, Yoshiaki Isshiki, Yasuhiko Shiratori, Kiyoshi Hasegawa, Takaaki Fukami, Takaaki Miura, Naomi Ono, Toshikazu Yamazaki, Young-Jun Na, Dong-Oh Yoon, Sung-Jin Kim
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Publication number: 20090215730Abstract: Chemical compounds derived by in silico molecular modelling, having a well defined structure suitable for the blocking of the phosphorylation event, through the specific interaction of the chemical with the Casein Kinase 2 enzyme substrate phosphorylation domain or it's neighbourhood. This invention comprises also the pharmaceutical compositions containing such compounds, and their use in the preparation of medicines or agents for the treatment of diseases or conditions related with neoplasic processes.Type: ApplicationFiled: May 5, 2006Publication date: August 27, 2009Inventors: Rolando Eduardo Rodriguez Fernandez, Roberto Vera Alvarez, Ania De La Nuez Veulens, Yuliet Mazola Reyes, Silvio Ernesto Perea Rodriguez, Boris Ernesto Acevedo Castro, Alexis Musacchio Lasa, Raimundo Ubieta Gomez
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Publication number: 20090215777Abstract: The invention provides a compound for use as an inhibitor of Hsp90, the compound having the formula (I): or salts, tautomers, solvates or N-oxides thereof; wherein: A is N or a group CR3; R1 is a monocyclic or bicyclic carbocyclic or heterocyclic ring of 5 to 10 ring members of which up to two ring members may be heteroatoms selected from N, O and S and the remainder are carbon atoms, the carbocyclic or heterocyclic ring being optionally substituted by one or more substituent groups independently selected from R10; and R2, R3 and R10 are as defined in the claims.Type: ApplicationFiled: May 19, 2006Publication date: August 27, 2009Applicant: Astex Therapeutics Ltd.Inventors: Gianni Chessari, Miles Stuart Congreve, Owen Callaghan, Suzanna Ruth Cowan, Christopher William Murray, Alison Jo-Anne Woolford, Michael Alistair O'Brien, Andrew James Woodhead
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Publication number: 20090093481Abstract: (1,3,5)-Triazinyl phenyl hydrazones are effective at controlling insects.Type: ApplicationFiled: September 26, 2008Publication date: April 9, 2009Applicant: Dow AgroSciences LLCInventors: Noormohamed M. Niyaz, Katherine A. Guenthenspberger, Ricky Hunter, Annette V. Brown, Jaime S. Nugent
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Publication number: 20090093486Abstract: N-Azinyl-N?-aryl ureas and thioureas derivatives are effective at controlling insects.Type: ApplicationFiled: September 26, 2008Publication date: April 9, 2009Applicant: Dow AgroSciences LLCInventors: Noormahamed M. Niyaz, Ricky Hunter, Timothy C. Johnson, Tony K. Trullinger, Annette V. Brown, Kristy Bryan
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Publication number: 20090074825Abstract: The present invention includes methods, articles, compositions and colorant dyes and pigments that include biocidal N-halamine dye composition having two or more heterocyclic ring structures attached to one or more N-halamine groups, wherein one or more halogens associate with the one or more one or more N-halamine groups to affect biocidal activity.Type: ApplicationFiled: September 19, 2008Publication date: March 19, 2009Applicant: Board of Regents, The University of Texas SystemInventors: Yuyu Sun, Jie Luo
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Publication number: 20090074820Abstract: The invention relates to the use of at least one agent for screening out light radiation with a wavelength ranging from 370 to 500 nm as an agent for inhibiting the degradation of endogenous carotenoids present in the skin. The invention is useful for treating skin disorders caused by sunlight (e.g., solar urticaria, actinic dermatitis and pigmentation marks). The invention also relates to novel aminoaryl-vinyl-s-triazine compounds and to the use thereof as agents for screening out light radiation ranging from 370 to 500 nm.Type: ApplicationFiled: November 25, 2008Publication date: March 19, 2009Applicant: L'OREALInventors: Didier Candau, Albert Duranton, Francis Pruche, Herve Richard
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Publication number: 20080210907Abstract: An ionic organic compound having a repeating unit of formula (I) can be synthesized easily from a readily available organic compound through a small number of reaction steps, can be produced without any purification technique such as chromatography, and can be used in a quite small amount for gelation of water or an ionic liquid without any other auxiliary solvent: [-(A-B-C)n-]•m(X) ??(I) wherein A represents a group having a quaternary ammonium cation which is formed from a heterocyclic compound having at least one nitrogen atom; B represents a functional group, which may have a substituent, selected from amide, urea, urethane and peptide groups; C represents a divalent hydrocarbon group, which may have a substituent, capable of linking between A and B; X represents an anion; n represents the number of repeating units; m represents the total number of anions; and n and m are the same integer.Type: ApplicationFiled: January 30, 2006Publication date: September 4, 2008Applicant: NAATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGYInventors: Masaru Yoshida, Nagatoshi Koumura, Nobuyuki Tamaoki, Hajime Kawanami, Hajime Matsumoto, Said Kazaoui, Nobutsugu Minami
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Publication number: 20080194817Abstract: Dyes of the hereinbelow indicated and defined formula (1) where R and M are each as defined in claim 1, process for their preparation and their use for dyeing and printing hydroxyl- and carboxamido-containing material.Type: ApplicationFiled: March 21, 2006Publication date: August 14, 2008Applicant: DyStar Textilfarben GmbH & Co. Deutschland KGInventors: Stefan Meier, Uwe Reiher, Werner Hubert Russ
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Publication number: 20080194583Abstract: Compounds of general formula (I), (II) (III) and (V) are described for use in modulating microtubule polymerisation and in the treatment of associated disease states. Use of compounds (I), (III) and (V) in the treatment of kinase-associated disease states is also described. Further described are novel compounds of formula (II), (III) and (V).Type: ApplicationFiled: December 3, 2004Publication date: August 14, 2008Inventors: Christopher John Burns, Andrew Frederick Wilks, Michael Francis Harte, Harrison Sikanyika, Emmanuelle Fantino, Collette Gloria Kewdale
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Patent number: 7285550Abstract: The invention is based on the discovery that compounds of formula (I) possess unexpectedly high affinity for the A2a adenosine receptor, and can be useful as antagonists thereof for preventing and/or treating numerous diseases, including Parkinson's disease.Type: GrantFiled: April 9, 2004Date of Patent: October 23, 2007Assignee: Biogen Idec MA Inc.Inventors: Chi Vu, Russell C. Petter, Gnanasambandam Kumaravel
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Patent number: 7189848Abstract: The present invention relates to a compound of the formula (I) The compound according to the invention is suitable for the preparation of herbicidal active substances such as sulfonylureas.Type: GrantFiled: March 7, 2005Date of Patent: March 13, 2007Assignee: Bayer CropScience GmbHInventors: Klaus Lorenz, Hans-Joachim Ressel, Lothar Willms
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Patent number: 7183409Abstract: The invention relates to basic mono- and bisazo compounds according to formula (I) wherein all substituents are defined as in Claim 1, their production, their use as dyestuffs as well as material dyed with these dyestuffs.Type: GrantFiled: May 29, 2002Date of Patent: February 27, 2007Assignee: Clariant Finance (BVI) LimitedInventors: Friedrich Lehr, Reinhard Pedrazzi, Heidrun Schene
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Patent number: 7109329Abstract: This invention provides pharmacologically active compounds having neurological and other bio-active capability. These active compounds comprise the derivatives of guanidino, aminoguanidino, 2-imadazolino, 2-hydrazinoimidazolino or 2-guanidinobenzimidazolino groups.Type: GrantFiled: July 1, 2002Date of Patent: September 19, 2006Inventor: N. Eric Naftchi
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Patent number: 7087753Abstract: Novel compounds of formula I are described wherein E corresponds to the formula or to the formula and the radicals R1, R2, R11, R22, R?22, R?33 and R?33 are as defined in claim 1. Compounds of formula I are suitable for stabilizing organic material, especially plastics materials, surface-coatings, cosmetic preparations, sun protection agents or photographic material, against damage by light, oxygen and/or heat.Type: GrantFiled: April 4, 2005Date of Patent: August 8, 2006Assignee: Ciba Specialty Chemicals Corp.Inventors: Vien Van Toan, Georges Metzger, Thomas Schäfer, Stéphane Biry, Christophe Bulliard, Dieter Reinehr, Peter Michaelis
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Patent number: 7002011Abstract: Compounds of the formula (I) or salts thereof are suitable for preparing active substances from the from the class of the aminotriazines of the formula (IV), for example herbicidal active substances. The compounds (I) can be prepared by chlorinating compounds of the formula (II) where, in the formulae, R1, R2, R3 and X are as defined in claim 1 and A and R have the meaning required in the active substances to be prepared, and they can be reacted with amines of the formula A—NH—R to give the active substances.Type: GrantFiled: July 2, 1999Date of Patent: February 21, 2006Assignee: Aventis CropScience GmbHInventors: Jürgen Zindel, Jens Hollander, Klemens Minn, Lothar Willms
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Patent number: 6881737Abstract: The invention encompasses compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions, uses and methods for prophylaxis and treatment of cancer and polycystic kidney disease.Type: GrantFiled: April 10, 2002Date of Patent: April 19, 2005Assignee: Amgen Inc.Inventors: John L. Buchanan, Joseph L. Kim, Perry M. Novak, Joseph J. Nunes, Vinod F. Patel
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Patent number: 6864255Abstract: The invention encompasses compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions, uses and methods for prophylaxis and treatment of cancer and angiogenesis-related disease.Type: GrantFiled: April 10, 2002Date of Patent: March 8, 2005Assignee: Amgen Inc.Inventors: Stephanie D. Geuns-Meyer, Lucian V. DiPietro, Joseph L. Kim, Vinod F. Patel
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Patent number: 6861389Abstract: The compounds of the formula (I) and their salts where the radicals R1 to R4, A1, A2, L0, X and n are as defined in claim 1 are suitable as herbicides and plant growth regulators and can be prepared by processes as claimed in claim 6.Type: GrantFiled: October 1, 2002Date of Patent: March 1, 2005Assignee: Aventis CropScience GmbHInventors: Wolfgang Giencke, Lothar Willms, Thomas Auler, Hermann Bieringer, Hubert Menne
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Patent number: 6858609Abstract: This invention concerns the compounds of formula the pharmaceutically acceptable acid addition salts and the stereochemically isomeric forms thereof, wherein R1 and R2 are each independently selected from hydrogen; hydroxy; amino; optionally substituted C1-6alkyl; C1-6alkyloxy; C1-6alkylcarbonyl; C1-6alkyloxycarbonyl; Ar1; mono- or di(C1-6alkyl)amino; mono- or di(C1-6alkyl)-aminocarbonyl; dihydro-2(3H7)-furanone; or R1 and R2 taken together may form pyrrolidinyl, piperidinyl, morpholinyl, azido or mono- or di(C1-6alkyl)amino-C1-4alkylidene; R3 is hydrogen, Ar1, C1-6alkylcarbonyl, C1-6alkyl, C1-6alkyloxy-carbonyl, C1-6alkyl substituted with C1-6alkyloxycarbonyl; and R4, R5, R6, R7 and R8 are each independently selected from hydrogen, halo, C1-6alkyl, C1-6alkyloxy, cyano, aminocarbonyl, nitro, amino, trihalomethyl or trihalomethyloxy; L is optionally substituted C1-10alkyl; C3-10alkenyl; C3-10alkynyl; C3-7cycloalkyl; Ar1 is optionally substituted phenyl; for the manufacture of a medicine for the treatment oType: GrantFiled: November 15, 2001Date of Patent: February 22, 2005Assignee: Janssen Pharmaceutica N.V.Inventors: Paul A. J. Janssen, Jan Heeres, Henri E. L. Moereels, Michael Joseph Kukla, Donald W. Ludovici
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Patent number: 6852717Abstract: Disclosed are compounds useful in pharmaceutic compositions for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are processes of making such compounds.Type: GrantFiled: May 10, 2002Date of Patent: February 8, 2005Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.Inventors: Pier Francesco Cirillo, Daniel R. Goldberg, Abdelhakim Hammach, Neil Moss, John Robinson Regan
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Patent number: 6806268Abstract: Provided, among things, is a method of decreasing intraocular pressure in an animal, including a human, comprising administering an intraocular pressure decreasing amount of a compound of the formula IA and or IB:Type: GrantFiled: May 30, 2002Date of Patent: October 19, 2004Assignee: Alteon, Inc.Inventor: Martin Gall
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Patent number: 6800757Abstract: The present invention relates to novel red-shifted UV absorbers comprising 1,3,5-triazine structures containing a 2-naphthol-derived substituent. The present invention also relates to a method for stabilizing a material by incorporating into such material, e.g., organic material, the novel red-shifted triazine compounds in an amount effective to stabilize the material against the effects of actinic radiation.Type: GrantFiled: September 27, 2001Date of Patent: October 5, 2004Assignee: Cytec Technology Corp.Inventors: Ram Baboo Gupta, Hargurpreet Singh, Russell C. Cappadona
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Patent number: 6790943Abstract: A reactive dye compound comprising: (a) at least one chromophore moiety; (b) at least one SO2C2H4 group which is attached to the chromophore moiety either directly via the sulphur atom of the SO2C2H4 group or via a linking group L; characterized in that at least one SO2C2H4 group is substituted on its terminal carbon atom with at least one Y group wherein Y is derived from a hydrated aldehyde, a hydrated ketone, a hydrated alpha-hydroxy ketone or the hydrated form of formic acid, and linked via one of its oxygen atoms to the terminal carbon of the SO2C2H4 group thereby forming a hemiacetal.Type: GrantFiled: March 27, 2002Date of Patent: September 14, 2004Assignee: North Carolina State UniversityInventors: Peter Jeffrey Broadbent, David Malcolm Lewis, Gilles Yves Marie Fernand Genain, Wei Dong He, Taher Iqbal Yousaf
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Publication number: 20040171616Abstract: The invention relates to polycyclic aryl and heteroaryl substituted 1,4-quinone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety of thrombotic conditions including coronary artery and cerebrovascular diseases.Type: ApplicationFiled: February 19, 2003Publication date: September 2, 2004Inventors: Michael S. South, John J. Parlow
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Patent number: 6761758Abstract: Disclosed are compounds of the formulae wherein, provided that at least one of R1, R2, R3, R4, R5, and R6 is a hydrogen atom, and provided that at least one of R1, R2, R3, R4, R5, and R6 is not a hydrogen atom, R1, R2, R3, R4, R5, and R6 each, independently of the others, is (i) a hydrogen atom, (ii) an alkyl group, (iii) an aryl group, (iv) an arylalkyl group, or (v) an alkylaryl group. Also disclosed are phase change ink compositions comprising a colorant and a phase change ink carrier comprising a material of this formula.Type: GrantFiled: September 4, 2002Date of Patent: July 13, 2004Assignee: Xerox CorporationInventors: Danielle C. Boils-Boissier, Marcel P. Breton, Jule W. Thomas, Jr., Donald R. Titterington, Jeffrey H. Banning, H. Bruce Goodbrand, James D. Wuest, Marie-Eve Perron, Francis Monchamp, Hugues Duval
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Publication number: 20040116424Abstract: The invention provides Aryl substituted imidazoles, pyrazoles, pyridizines and related compounds of the Formula 1Type: ApplicationFiled: March 28, 2003Publication date: June 17, 2004Applicant: Neurogen CorporationInventors: George P. Luke, George D. Maynard, Scott Mitchell, Andrew Thurkauf, Linghong Xie, LuYan Zhang, Suoming Zhang, He Zhao, Bertrand L. Chenard, Yang Gao, Bingsong Han, Xiao Shu He
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Patent number: 6743817Abstract: Disclosed are compounds of the formula and the pharmaceutically acceptable salts thereof wherein R, Ar, A, n, R1 and R2 are defined herein. These compounds are highly selective agonists, antagonists or inverse agonists for GABAA brain receptors or prodrugs of agonists, antagonists or inverse agonists for GABAA brain receptors and are therefore useful in the diagnosis and treatment of anxiety, depression, Down Syndrome, sleep and seizure disorders, overdose with benzodiazepine drugs and for enhancement of memory. Pharmaceutical compositions, including packaged pharmaceutical compositions, are also disclosed.Type: GrantFiled: September 6, 2001Date of Patent: June 1, 2004Assignee: Neurogen CorporationInventors: George Maynard, LingHong Xie, Stanislaw Rachwal
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Publication number: 20040097376Abstract: The invention relates to novel substituted aryl ketones of the formula (I) 1Type: ApplicationFiled: July 17, 2003Publication date: May 20, 2004Inventors: Klaus-Helmut Muller, Stefan Herrmann, Dorothee Hoischen, Stefan Lehr, Hans-Georg Schwarz, Otto Schallner, Mark Wilhelm Drewes, Peter Dahmen, Dieter Feucht, Rolf Pontzen
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Patent number: 6723834Abstract: A reactive dye compound comprising: (a) at least one chromophore moiety; (b) at least one nitrogen-containing heterocycle (c) a linking group to link each chromophore moiety to each nitrogen-containing heterocycle; characterized in that at least one nitrogen-containing heterocycle is substituted with at least one Y group wherein Y is derived from a hydrated aldehyde, a hydrated ketone, a hydrated alpha-hydroxy ketone, or the hydrated form of formic acid and linked via one of its oxygen atoms to the nitrogen-containing heterocycle thereby forming a hemiacetal.Type: GrantFiled: March 27, 2002Date of Patent: April 20, 2004Assignee: North Carolina State UniversityInventors: Peter Jeffrey Broadbent, Dong Wei He, David Malcolm Lewis, Gilles Yves Marie Fernand Ganain, Taher Iqbal Yousaf
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Publication number: 20040073028Abstract: This invention relates to a novel, efficient, economic and general-purpose process for isolating monophenolic-bisaryl triazine compounds from polyphenolic-triazines compounds and other impurities. More specifically, this invention relates to a process for isolating the monophenolic-bisaryl triazine compounds by contacting it with a base, an alcohol or a hydrocarbon solvent.Type: ApplicationFiled: October 7, 2003Publication date: April 15, 2004Inventors: Ram Baboo Gupta, Hargurpreet Singh, Russell C. Cappadona
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Publication number: 20040063705Abstract: The invention encompasses compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions, uses and methods for prophylaxis and treatment of cancer.Type: ApplicationFiled: August 21, 2002Publication date: April 1, 2004Inventors: Jean-Christophe Harmange, Shon Booker, John L. Buchanan, Stuart Chaffee, Perry M. Novak, Simon Van Der Plas, Xiaotian Zhu
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Patent number: 6713613Abstract: A reactive dye compound comprising: (a) at least one chromophore moiety (b) at least one nitrogen-containing heterocycle (c) a linking group to link each chromophore moiety to each nitrogen-containing heterocycle; characterised in that at least one nitrogen-containing heterocycle is substituted with at least one oxy- or thio-carbonyl derivative wherein the oxy- or thio-carbonyl derivative is selected from Y wherein Y is —A(CO)R* wherein A is selected from O or S and wherein R* is an organic residue which comprises at least one nucleophilic group, and salts thereof.Type: GrantFiled: November 8, 2001Date of Patent: March 30, 2004Assignee: North Carolina State UniversityInventors: David Malcolm Lewis, Wei Dong He, Taher Iqbal Yousaf, Gilles Yves Marie Fernand Genain
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Publication number: 20040050295Abstract: Disclosed are compounds of the formulae 1Type: ApplicationFiled: September 4, 2002Publication date: March 18, 2004Applicant: Xerox CorporationInventors: Danielle C. Boils-Boissier, Marcel P. Breton, Jule W. Thomas, Donald R. Titterington, Jeffrey H. Banning, H. Bruce Goodbrand, James D. Wuest, Marie-Eve Perron, Francis Monchamp, Hugues Duval
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Publication number: 20040034222Abstract: Compounds of the formula (I) or salts thereof 1Type: ApplicationFiled: January 30, 2003Publication date: February 19, 2004Inventors: Jens Hollander, Lothar Willms, Jurgen Zindel, Wolfgang Giencke, Hermann Bieringer, Christopher Rosinger, Thomas Auler, Felix Thurwachter
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Patent number: 6677341Abstract: The invention relates to substituted aryl and heteroaryl (R)-Chiral Halogenated 1-Substitutedamino-(n+1)-Alkanol compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atherosclerosis and other coronary artery diseases. Novel high yield, stereoselective processes for the preparation of the chiral substituted alkanol compounds from chiral and achiral intermediates are described. Preferred (R)-Chiral 1-Substitutedamino-(n+1)-Alkanol compounds are substituted (R)-Chiral heteroaryl aminoalcohols.Type: GrantFiled: December 12, 2001Date of Patent: January 13, 2004Assignee: Pharmacia CorporationInventors: James A. Sikorski, Richard C. Durley, Margaret L. Grapperhaus, Mark A. Massa, Emily J. Reinhard, Yvette M. Fobian, Michael B. Tollefson, Lijuan Wang, Brian S. Hickory, Monica B. Norton, William F. Vernier, Deborah A. Mischke, Michele A. Promo, Ashton T. Hamme, Dale P. Spangler, Melvin L. Rueppel
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Publication number: 20030225086Abstract: The invention relates to polycyclic aryl and heteroaryl substituted 1,4-quinone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety of thrombotic conditions including coronary artery and cerebrovascular diseases.Type: ApplicationFiled: February 19, 2003Publication date: December 4, 2003Inventors: Michael S. South, John J. Parlow
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Publication number: 20030225087Abstract: The present invention provides novel N-alkyl-N-phenylhydroxylamine derivatives containing metal chelating groups, a process for preparing the same, the use of the novel compounds as therapeutics for treating and/or preventing various medical dysfunctions and diseases arising from reactive oxygen species (ROS) and/or excess Zn ions, in particular stroke, Parkinson's disease and Alzheimer's disease. The compounds of the invention possess similar or superior LPO inhibition activity to the reference compounds of Trolox and Ebselen. While showing lower toxicity, they also effectively inhibit the cerebral neuronal cell death caused by ROS and/or zinc ion, and show neuroprotective effects against ischemic neuronal degeneration.Type: ApplicationFiled: June 5, 2003Publication date: December 4, 2003Inventors: Eu-Gene Oh, Sung-Bo Ko, Won-Yeob Kim, Kyung-Hwa Kim, Dennis W. Choi, Laura L. Dugan, Tae-Cheon Kang, Jae-Young Koh, Kyung-Mi Kim, In-Jae Shin