Hetero Ring Patents (Class 544/212)
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Publication number: 20130112946Abstract: A heterocyclic compound represented by Formula 1 below and an organic light-emitting device including the heterocyclic compound: wherein X1 and X2, X1 and R1 to R10 are defined as in the specification.Type: ApplicationFiled: February 29, 2012Publication date: May 9, 2013Applicant: SAMSUNG MOBILE DISPLAY CO., LTD.Inventors: Bum-Woo Park, Yoon-Hyun Kwak, Sun-Young Lee, Chang-Ho Lee, Se-Jin Cho
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Publication number: 20130113367Abstract: A heterocyclic compound represented by Formula 1A and an organic light-emitting device including the heterocyclic compound: at least one of R1 to R13 is a group represented by Formula 1B below: wherein R1 to R15, Ar1, Ar2, A, B, a, and b are defined as in the specification. The organic light-emitting device may include an organic layer containing the heterocyclic compound, and thus may have a low driving voltage, a high-emission efficiency, and long lifespan characteristics.Type: ApplicationFiled: April 12, 2012Publication date: May 9, 2013Applicant: Samsung Mobile Display Co., Ltd.Inventors: Hye-Jin Jung, Seok-Hwan Hwang, Young-Kook Kim, Jin-O Lim, Sang-Hyun Han, Soo-Yon Kim, Dae-Yup Shin
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Publication number: 20130109693Abstract: The present invention relates to a compound of the following general formula (I): wherein: R1 is notably H, a halogen or an aryl group, R2 is notably a halogen or an aryl group, R3 is notably a halogen, or an aryl or heteroaryl group, as well as to its pharmaceutically acceptable salts, its hydrates or its polymorphic crystalline structures, its racemates, diastereoisomers or enantiomers, except the compound 1-(2,4-diaminopyrido[3,2-d]pyrimidin-7-yl)-3,6,6-trimethyl-6,7-dihydro-1H-indol-4(5H)-one.Type: ApplicationFiled: April 28, 2011Publication date: May 2, 2013Applicants: UNIVERSITE D'ORLEANS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S)Inventors: Sylvain Routier, Gérald Guillaumet, Abdellatif Tikad, Oussama Dehbi
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Publication number: 20130105769Abstract: A condensed-cyclic compound represented by Formula 1, and an organic light-emitting device including the condensed-cyclic compound. wherein R1 and R2, Ar1 through Ar4, L1 and L2, X1 and X2, and a and b are defined as in the specification.Type: ApplicationFiled: May 22, 2012Publication date: May 2, 2013Applicant: SAMSUNG MOBILE DISPLAY CO., LTD.Inventors: Jin-O Lim, Seok-Hwan Hwang, Young-Kook Kim, Hye-Jin Jung, Sang-Hyun Han, Soo-Yon Kim, Hee-Joo Ko
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Publication number: 20130109694Abstract: The present invention is related to novel compounds of formula (I) having antibacterial activity against Clostridium bacteria, in particular Clostridium perfringens, pharmaceutical compositions comprising these compounds, and chemical processes for preparing these compounds.Type: ApplicationFiled: August 4, 2011Publication date: May 2, 2013Applicant: ELANCO ANIMAL HEALTH IRELAND LIMITEDInventors: Jerome Emile Georges Guillemont, Pierre Jean-Marie Bernard Raboisson, Nacer Lounis
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Publication number: 20130099171Abstract: The present invention relates to compounds of the formula (1) which are suitable for use in electronic devices, in particular organic electroluminescent devices, and to electronic devices which comprise these compounds.Type: ApplicationFiled: May 30, 2011Publication date: April 25, 2013Applicant: Merck Patent GmbHInventors: Esther Breuning, Heinrich Becker, Junyou Pan, Herwig Buchholz, Teresa Mujica-Fernaud, Irina Martynova
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Publication number: 20130092922Abstract: The present invention relates to an electronic device comprising anode, cathode and at least one organic layer which comprises a compound of the formula (I) to (IV). The invention furthermore encompasses the use of compounds of the formula (I) to (IV) in an electronic device and to a compound of the formula (Ic) to (IVc).Type: ApplicationFiled: May 30, 2011Publication date: April 18, 2013Applicant: Merck Patent GmbHInventors: Philipp Stoessel, Arne Buesing, Dominik Joosten
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Publication number: 20130087768Abstract: A heterocyclic compound represented by Formula 1 below, an organic light-emitting diode including the same, and a flat panel display device including the organic light-emitting diode: where X is *—Ar1 or wherein Ar1, Ar2, R1, R2, R3, R4, Y1, Y2, Y3, Y4, a, b, c, and d are as defined in the specification.Type: ApplicationFiled: February 17, 2012Publication date: April 11, 2013Applicant: SAMSUNG MOBILE DISPLAY CO., LTD.Inventors: Young-Kook Kim, Seok-Hwan Hwang, Hye-Jin Jung, Jin-O Lim, Sang-Hyun Han, Se-Jin Cho, Jong-Hyuk Lee
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Patent number: 8415341Abstract: Disclosed are compounds, compositions and methods for treating diseases, syndromes, conditions and disorders that are affected by the inhibition of MGL, including pain. Such compounds are represented by Formula (I) as follows: wherein Y, r, R2 and Z are defined herein.Type: GrantFiled: April 22, 2010Date of Patent: April 9, 2013Assignee: Janssen Pharmaceutica, NVInventors: Kristen Chevalier, Jose Clemente, Scott Dax, Chris Flores, Li Liu, Mark Macielag, Mark McDonnell, Marina Nelen, Erica Nulton, Stephen Prouty, Matthew Todd, Sui-Po Zhang, Bin Zhu
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Publication number: 20130079303Abstract: The present invention relates to compounds of Formula I, or a pharmaceutically acceptable salt thereof; methods of treating diseases or conditions, such as cancer, using the compounds; and pharmaceutical compositions containing the compounds, wherein the variables are as defined herein.Type: ApplicationFiled: November 19, 2012Publication date: March 28, 2013Applicant: AMGEN INC.Inventor: Amgen Inc.
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Publication number: 20130079345Abstract: The present invention relates to disubstituted triazine derivatives and/or pharmaceutically acceptable salts thereof, the use of these derivatives as pharmaceutically active agents, especially for the prophylaxis and/or treatment of infectious diseases, including opportunistic diseases, immunological diseases, autoimmune diseases, cardiovascular diseases, cell proliferative diseases, inflammation, erectile dysfunction and stroke, and pharmaceutical compositions containing at least one of said disubstituted triazine derivatives and/or pharmaceutically acceptable salts thereof. Furthermore, the present invention relates to the use of said disubstituted triazine derivatives as inhibitors for a protein kinase.Type: ApplicationFiled: March 20, 2011Publication date: March 28, 2013Applicants: BAYER INTELLECTUAL PROPERTY GMBH, LEAD DISCOVERY CENTER GMBHInventors: Jan Eickhoff, Peter Nussbaumer, Gerd Ruhter, Carsten Schultz-Fademrecht, Ulrich Lucking, Axel Choidas, Bert Klebl
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Patent number: 8404765Abstract: The present invention relates to polypiperidine compounds capable of conferring to polymeric materials, particularly polyolefins, a high stability against photodegradation and oxidative action of air, which belong to the HALS category and have the following general formula (I) in which x can be zero or 1; y is between 1 and 10; m and n, which may be different or equal to each other, range from 2 to 8; A represents a NPiR1 group or a NR2R3 group; and Pi represents the group of formula (II) wherein R1 is selected from the group consisting of H, C1-C4 straight-chain and branched-chain alkyl groups; R2 and R3 can be the same or different and are selected in the group consisting of H, C1-C8 straight-chain and branched-chain alkyl groups, cyclic alkyl groups having from 5 to 12 carbon atoms, or form together with the nitrogen atom a heterocyclic ring having from 5 to 7 members, comprising other heteroatoms such as O, R4 is selected from the group consisting of H, C1-C4 straight-chain and branched-Type: GrantFiled: February 8, 2010Date of Patent: March 26, 2013Assignee: 3V Sigma S.p.A.Inventors: Luca Bemporad, Ferruccio Berte, Carlo Seccomandi
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Publication number: 20130056720Abstract: A compound for an organic optoelectronic device and an organic photoelectric device including the same are provided. A compound for an organic optoelectronic device represented by Chemical Formula 1 is provided to fabricate an organic photoelectric device having excellent electrochemical and thermal stability and life-span characteristics, and high luminous efficiency at a low driving voltage.Type: ApplicationFiled: November 5, 2012Publication date: March 7, 2013Inventors: Hyung-Sun KIM, Eun-Sun YU, Mi-Young CHAE, Ho-Jae LEE, Soo-Hyun MIN
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Patent number: 8389442Abstract: The use of fungicidal compounds of formula Ij wherein A and A? are both N or A and A? are both CH or A is CH and A? is N; j is 0 or 1 and the R groups are as defined in claim 1; their preparation and compositions 10 comprising the compounds.Type: GrantFiled: March 25, 2004Date of Patent: March 5, 2013Assignee: Syngenta Crop Protection LLCInventors: Peter Ackermann, Daniel Stierli, Martin Diggelmann, Fredrik Cederbaum, Jean Wenger, Ruud Titulaer
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Publication number: 20130048956Abstract: The present invention provides a compound of formula (I) for an organic electroluminescent device: wherein X1, X2, X3, Y, Ar1, Ar2, Ar3, Ar4, Ar5, Ar6, and Ar7 are as defined in the description.Type: ApplicationFiled: June 8, 2012Publication date: February 28, 2013Applicant: E-RAY OPTOELECTRONICS TECHNOLOGY CO., LTD.Inventors: Banumathy Balaganesan, Yi-Huan Fu, Kun-Feng Chiang, Fang-Shih Lin, Zheng-Feng Ye, Chang-Ying Chu
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Publication number: 20130032787Abstract: A heterocyclic compound represented by Formula 1 or Formula 2 below, and an organic light-emitting device including the heterocyclic compound. The organic light-emitting device may include an organic layer containing the heterocyclic compound, and thus may have a low driving voltage, a high-emission efficiency, and long lifespan characteristics. wherein R1 to R12, Ar1, Ar2, A, B, a, and b are defined as in the specification.Type: ApplicationFiled: November 25, 2011Publication date: February 7, 2013Applicant: SAMSUNG MOBILE DISPLAY CO., LTD.Inventors: Young-Kook Kim, Seok-Hwan Hwang, Hye-Jin Jung, Jin-O Lim, Sang-Hyun Han, Se-Jin Cho, Jong-Hyuk Lee
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Publication number: 20130029982Abstract: Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein.Type: ApplicationFiled: July 18, 2012Publication date: January 31, 2013Applicants: INTELLIKINE, LLC, INFINITY PHARMACEUTICALS, INC.Inventors: Alfredo C. Castro, Catherine A. Evans, Somarajannair Janardanannair, Andre Lescarbeau, Tao Liu, Daniel A. Snyder, Martin R. Tremblay, Pingda Ren, Yi Liu, Liansheng Li, Katrina Chan
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Publication number: 20130023497Abstract: The present invention comprises inter alia triazine compounds as shown in formula (I) and pharmaceutically acceptable salts thereof.Type: ApplicationFiled: June 7, 2010Publication date: January 24, 2013Inventors: Chunlin Tao, Qinwei Wang, Tulay Polat, Laxman Nallan, Neil Desai
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Publication number: 20130001524Abstract: A heterocyclic compound represented by Formula 1 below and an organic light-emitting device including an organic layer that includes the following heterocyclic compound: wherein R1 to R13 are each independently a hydrogen atom, a heavy hydrogen atom, a substituted or unsubstituted C1-C60 alkyl group, a substituted or unsubstituted C2-C60 alkenyl group, a substituted or unsubstituted C2-C60 alkynyl group, a substituted or unsubstituted C3-C60 cycloalkyl group, a substituted or unsubstituted C1-C60 alkoxy group, a substituted or unsubstituted C5-C60 aryloxy group, a substituted or unsubstituted C5-C60 arylthio group, a substituted or unsubstituted C5-C60 aryl group, an amino group substituted with a C5-C60 aryl group or a C3-C60 heteroaryl group, a substituted or unsubstituted C3-C60 heteroaryl group, a substituted or unsubstituted C6-C60 condensed polycyclic group, a halogen atom, a cyano group, a nitro group, a hydroxy group, or a carboxy group.Type: ApplicationFiled: December 8, 2011Publication date: January 3, 2013Applicant: SAMSUNG MOBILE DISPLAY CO., LTD.Inventors: Jin-O Lim, Seok-Hwan Hwang, Young-Kook Kim, Hye-Jin Jung, Sang-Hyun Han, Chang-Ho Lee, Jong-Hyuk Lee, Hee-Joo Ko
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Publication number: 20120326134Abstract: A heterocyclic compound, an organic light-emitting diode, and a flat display device, the heterocyclic compound being represented by Formula 1, below:Type: ApplicationFiled: December 6, 2011Publication date: December 27, 2012Inventors: Young-Kook KIM, Seok-Hwan HWANG, Hye-Jin JUNG, Jin-O LIM, Sang-Hyun HAN, Yoon-Hyun KWAK, Sun-Young LEE, Hee-Joo KO, Jong-Hyuk LEE, Sung-Chul KIM
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Patent number: 8333988Abstract: Compositions and methods for tissue-specific targeted delivery of therapeutic agents through the use of tissue-specific peptidomimetic ligands are disclosed herein. The ligand comprises a composition of formula A-scaffold-A? and one or more hydrophobic anchors covalently linked to the scaffold. The A and A? compounds linked to the scaffold comprise monovalent peptidomimetic compounds wherein each monovalent peptidomimetic compound is selected from the group consisting of fragments IKs, GKs, IDs, GSs, GTs, VSs, TKs, KTs, ARs, KIs, KEs, AEs, GRs, YSs, IRs, and morpholino.Type: GrantFiled: September 3, 2010Date of Patent: December 18, 2012Assignee: GRADALIS, Inc.Inventor: Nancy Smyth Templeton
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Publication number: 20120316171Abstract: Methods and compositions for the treatment and/or management of cancer are disclosed, which comprise the use of tryptophan hydroxylase inhibitors.Type: ApplicationFiled: November 4, 2010Publication date: December 13, 2012Inventor: Tamas Oravecz
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Publication number: 20120316166Abstract: Novel hetarylaminonaphthyridine derivatives of formula (I) wherein X, R1, R2, R3, R4, W1, W2, W3, W5 and W6 have the meaning according to claim 1, are inhibitors of ATP consuming proteins, and can be employed, inter alia, for the treatment of tumors.Type: ApplicationFiled: January 10, 2011Publication date: December 13, 2012Applicant: MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNGInventors: Alfred Jonczyk, Dieter Dorsch, Frank Zenke, Christiane Amendt
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Publication number: 20120305851Abstract: The present invention relates to compounds of the formula (1) which are suitable for use in electronic devices, in particular organic electroluminescent devices, and to electronic devices which contain these compounds.Type: ApplicationFiled: December 17, 2010Publication date: December 6, 2012Applicant: Merck Patent GmbHInventors: Junyou Pan, Herwig Buchholz, Teresa Mujica-Fernaud, Irina Martynova
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Publication number: 20120292603Abstract: A heterocyclic compound includes compounds represented by Formula 1 or Formula 2 below:Type: ApplicationFiled: August 25, 2011Publication date: November 22, 2012Inventors: Yoon-Hyun Kwak, Seok-Hwan Hwang, Young-Kook Kim, Sun-Young Lee, Hye-Jin Jung, Jin-O Lim, Sang-Hyun Han, Hee-Joo Ko, Jong-Hyuk Lee
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Publication number: 20120277233Abstract: The invention provides pyridyl-triazine derivatives to inhibit the hedgehog signaling pathway and the use of such compounds in the treatment of hyperproliferative diseases and angiogenisis mediated diseases.Type: ApplicationFiled: June 8, 2010Publication date: November 1, 2012Applicant: California Capital Equity, LLCInventors: Chunlin Tao, Hongna Han, Xiaowen Sun, Neil Desai
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Publication number: 20120264751Abstract: Pyrrole pyrazole compounds of formula I, compositions including these compounds and methods of their use are provided. Preferred compounds of formula I have activity as protein kinase inhibitors, including as inhibitors of PAK4.Type: ApplicationFiled: October 6, 2011Publication date: October 18, 2012Inventors: Junhu ZHANG, Chuangxing Guo, Djamal Bouzida, Liming Dong, Haitao Li, Joseph Timothy Marakovits, Anle Yang, Yufeng Hong
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Publication number: 20120256169Abstract: Novel compounds containing substituted oligoazacarbazole chains are provided. These compounds are useful in organic light emitting devices, in particular as hosts in the emissive layer of such devices.Type: ApplicationFiled: April 8, 2011Publication date: October 11, 2012Applicant: Universal Display CorporationInventors: Alexey Dyatkin, Lichang Zeng
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Publication number: 20120252789Abstract: The present invention relates to compounds of the formula (I), in which R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17, M1, M2, M3, M4, Y1, Y2, V, W, n, m and o have the meanings given in Claim 1, and physiologically acceptable salts, derivatives, prodrugs, solvates, tautomers and stereoisomers thereof, including mixtures thereof in all ratios, for use in the treatment of diseases which are influenced by inhibition of Sph kinase 1.Type: ApplicationFiled: November 22, 2010Publication date: October 4, 2012Applicant: MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNGInventors: Frank Stieber, Dirk Wienke
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Publication number: 20120238105Abstract: The present invention relates to formula, comprising at least one solvent, and at least one functional composition of the general formula (I), wherein A is a functional structural element, B is a solvent-providing structural element, and k is an integer in the range of 1 to 20. The molecular weight of the functional composition is at least 550 g/mol, and the solvent-providing structural element B corresponds to the general formula ((L-I). Ar1, Ar2 JeWeUs, independently of each other, signify an aryl or heteroaryl group, which can be substituted with one or several discretionary residues R. Each X is, independently of one another, N or CR2, preferably CH.Type: ApplicationFiled: May 3, 2010Publication date: September 20, 2012Applicant: Merck Patent GmbHInventors: Rémi Manouk Anémian, Susanne Heun, Thomas Eberle, Philipp Stoessel
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Publication number: 20120238576Abstract: The present invention comprises inter alia compounds as shown in formula (I) or a pharmaceutically acceptable salt thereof.Type: ApplicationFiled: June 7, 2010Publication date: September 20, 2012Applicant: CALIFORNIA CAPITAL EQUITY, LLCInventors: Chunlin Tao, Qinwei Wang, Laxman Nallan, Tulay Polat, Lukasz Koroniak, Neil Desai
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Publication number: 20120228552Abstract: The present invention relates to organic electroluminescent devices which comprise fluorene derivatives and spirobifluorene derivatives as matrix material for phosphorescent emitters.Type: ApplicationFiled: October 28, 2010Publication date: September 13, 2012Applicant: Merck Patent GmbHInventors: Amir Hossain Parham, Joachim Kaiser, Anja Gerhard, Jonas Valentin Kroeber, Rémi Manouk Anémian
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Publication number: 20120223276Abstract: The present adventure relates to novel compounds of the formula (I) or (II), to the use of the compounds in electronic devices, to a process for the preparation of the compounds, and to electronic devices comprising the compounds, preferably as matrix materials or as electron-transport materials.Type: ApplicationFiled: October 20, 2010Publication date: September 6, 2012Applicant: MERCK PATENT GMBHInventors: Amir Hossain Parham, Christof Pflumm, Arne Buesing, Teresa Mujica-Fernaud, Irina Martynova, Holger Heil, Rémi Manouk Anémian
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Publication number: 20120223295Abstract: Provided are an organic electroluminescence device having high current efficiency and a long lifetime, and a biscarbazole derivative for realizing the device. The biscarbazole derivative has a specific substituent. The organic EL device has a plurality of organic thin-film layers including a light emitting layer between a cathode and an anode, and at least one layer of the organic thin-film layers contains the biscarbazole derivative.Type: ApplicationFiled: February 6, 2012Publication date: September 6, 2012Applicant: Idemitsu Kosan Co., Ltd.Inventors: Tetsuya Inoue, Mitsunori Ito, Tomoki Kato, Kumiko Hibino, Kazuki Nishimura, Takayasu Sado
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Publication number: 20120211701Abstract: The present invention relates to compounds of the formula (I), to mixtures of the said compounds with emitter compounds, to the use of compounds of the formula (I) and the said mixtures in electronic devices, and to electronic devices containing one or more compounds of the formula (I) and/or mixtures of compounds of the formula (I) with emitter compounds.Type: ApplicationFiled: October 1, 2010Publication date: August 23, 2012Applicant: Merck Patent GmbHInventors: Hubert Spreitzer, Jochen Schwaiger, Heinrich Becker
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Publication number: 20120211736Abstract: A compound for an organic photoelectric device, the compound being represented by the following Chemical Formula (“CF”) 1:Type: ApplicationFiled: May 3, 2012Publication date: August 23, 2012Applicant: CHEIL INDUSTRIES, INC.Inventors: Hyung-Sun KIM, Eun-Sun YU, Soo-Hyun MIN, Ho-Jae LEE, Eui-Su KANG, Mi-Young CHAE, Young-Hoon KIM, Ja-Hyun KIM
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Publication number: 20120206037Abstract: Provided are a novel organic electroluminescent compound and an organic electroluminescent device using the same. When used as a host material of an organic electroluminescent material of an OLED device, the organic electroluminescent compound disclosed herein exhibits good luminous efficiency and excellent life property as compared to the existing host material. Therefore, it may be used to manufacture OLEDs having very superior operation life.Type: ApplicationFiled: July 19, 2010Publication date: August 16, 2012Applicant: Rohm and Haas Electronic Materials Korea LtdInventors: Soo Young Lee, Young Gil Kim, Youngg Jun Cho, Hyuck Joo Kwon, Bong Ok Kim, Sung Min Kim, Seung Soo Yoon
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Publication number: 20120205636Abstract: A compound for an organic photoelectric device an organic photoelectric device, and a display device, the compound being represented by the following Chemical Formula 1:Type: ApplicationFiled: April 20, 2012Publication date: August 16, 2012Inventors: Young-Hoon Kim, Ja-Hyun Kim, Eun-Sun Yu, Ho-Jae Lee, Young-Sung Park, Mi-Young Chae, Hyung-Sun Kim, Soo-Hyun Min, Eui-Su Kang, Sung-Hyun Jung
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Publication number: 20120208812Abstract: Disubstituted octahydropyrrolo[3,4-c]pyrrole compounds are described, which are useful as orexin receptor modulators. Such compounds may be useful in pharmaceutical compositions and methods for the treatment of diseased states, disorders, and conditions mediated by orexin activity, such as insomnia.Type: ApplicationFiled: October 21, 2010Publication date: August 16, 2012Applicant: Janssen Pharmaceutica N.V.Inventors: Wenying Chai, Michael A. Letavic, Kiev S. Ly, Daniel J. Pippel, Dale A. Rudolph, Kathleen C. Sappey, Brad M. Savall, Chandravadan R. Shah, Brock T. Shireman, Akinola Soyode-Johnson, Emily M. Stocking, Devin M. Swanson
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Publication number: 20120202763Abstract: Compounds that selectively inhibit pathological production of human vascular endothelial growth factor (VEGF) and compositions comprising such Compounds are described. Compounds that inhibit viral replication or the production of viral RNA or DNA or viral protein and compositions comprising such Compounds are described. Also described are methods of reducing VEGF using such Compounds and methods for treating cancer and non-neoplastic conditions involving the administration of such Compounds. Further described are methods of inhibiting viral replication or the production of viral RNA or DNA or viral protein using such Compounds and methods for treating viral infections involving the administration of such Compounds. The Compounds may be administered as a single agent therapy or in combination with one or more additional therapies to a human in need of such treatments.Type: ApplicationFiled: May 27, 2010Publication date: August 9, 2012Applicant: PTC THERAPEUTICS, INCInventors: Neil Almstead, Tamil Arasu, Soongyu Choi, Liangxian Cao, Jeffrey Allen Campbelll, Donald Corson, Thomas W. Davis, Jason D. Graci, Zhengxian Gu, Peter Seong Woo Hwang, William Lennox, Harry H. Miao, Langdon Miller, Young-Choon Moon, Hongyan Qi, Christopher Trotta, Marla L. Weetall
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Publication number: 20120196860Abstract: The invention provides Triazine derivatives and further provides methods of using these compounds to modulate protein kinases and for treating diseases and conditions mediated by protein kinases.Type: ApplicationFiled: June 9, 2010Publication date: August 2, 2012Applicant: CALIFORNIA CAPITAL EQUITY, LLCInventors: Chunlin Tao, Qinwei Wang, Laxman Nallan, Tulay Polat, David Ho, Neil Desai
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Publication number: 20120190682Abstract: The invention relates to compounds of formula wherein R1, R2, R3, R4, and Ar are as defined in the specification and claims, or to pharmaceutically active acid addition salts of such compounds. Compounds of formula I are modulators for amyloid beta and may be useful for the treatment or prevention of a disease associated with the deposition of ?-amyloid in the brain, in particular Alzheimer's disease, and other diseases such as cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, Dutch-type (HCHWA-D), multi-infarct dementia, dementia pugilistica and Down syndrome.Type: ApplicationFiled: April 2, 2012Publication date: July 26, 2012Inventors: Erwin Goetschi, Synese Jolidon, Thomas Luebbers
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Publication number: 20120190666Abstract: The present invention provides compounds that are PIKK inhibitors, more specifically, mTOR and/or PI3K? kinase inhibitors and are therefore useful for the treatment of diseases treatable by inhibition of kinases, specifically PI3 kinases, more specifically, mTOR and/or PI3K?, such as cancer. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.Type: ApplicationFiled: May 12, 2010Publication date: July 26, 2012Applicant: Amgen Inc.Inventors: Christiane Bode, Alessandro Boezio, Alan C. Cheng, Deborah Choquette, James Robert Coats, Katrina Woodin Copeland, Hongbing Huang, Daniel La, Richard Thomas Lewis, Hongyu Liao, Michele Potashman, John Stellwagen, Shuyan Yi, Mark H. Norman, Markian M. Stec, Emily Anne Peterson, Russell Graceffa
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Publication number: 20120178758Abstract: The invention provides Styryl-Triazine derivatives, and further provides methods of using these compounds to modulate protein kinases and to treat protein kinase mediated diseases.Type: ApplicationFiled: June 8, 2010Publication date: July 12, 2012Applicant: CALIFORNIA CAPITAL EQUITY, LLCInventors: Chunlin Tao, Qinwei Wang, Neil Desai
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Publication number: 20120175598Abstract: The present invention provides a carbazole derivative of formula (I) for an organic electroluminescent device: wherein Y represents a heteroatom selected from N, O, P, S, or a bicyclic or tricyclic heterocyclic ring; and Ar1 and Ar2 each independently represent an alkyl or aryl substituted or unsubstituted aromatic hydrocarbon, or an alkyl or aryl substituted or unsubstituted heterocyclic aromatic hydrocarbon.Type: ApplicationFiled: December 5, 2011Publication date: July 12, 2012Applicant: E-RAY OPTOELECTRONICS TECHNOLOGY CO., LTD.Inventors: Banumathy Balaganesan, Kun-Feng Chiang, Huang-Ming Guo, Po-Wei Hsu
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Publication number: 20120171730Abstract: Methods for the synthesis of N-substituted pyridinium compounds by using an N-heteroaryl substituted pyridinium salt (Zincke salt) and reacting it with a nucleophilic amine are provided. Novel purine-substituted pyridyl compounds, which may be useful reagents in the above reaction, are also disclosed.Type: ApplicationFiled: January 27, 2012Publication date: July 5, 2012Applicant: ROCHE DIAGNOSTICS OPERATIONS, INC.Inventors: Dieter Heindl, Heribert Maerz, Axel Schmidt
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Publication number: 20120172361Abstract: Compounds of the formula (I) and formula (II) and pharmaceutically acceptable salts thereof.Type: ApplicationFiled: June 7, 2010Publication date: July 5, 2012Applicant: CALIFORNIA CAPITAL EQUITY, LLCInventors: Chunlin Tao, Qinwei Wang, Tulay Polat, Laxman Nallan, David Ho, Neil Desai
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Publication number: 20120172591Abstract: Methods of inhibiting phosphatidylinositol 3-kinase delta isoform (PI3K?) activity, and methods of treating diseases, such as disorders of immunity and inflammation, in which PI3K? plays a role in leukocyte function are disclosed. Preferably, the methods employ active agents that selectively inhibit PI3K?, while not significantly inhibiting activity of other PI3K isoforms. Compounds are provided that inhibit PI3K? activity, including compounds that selectively inhibit PI3K? activity. Methods of using PI3K? inhibitory compounds to inhibit cancer cell growth or proliferation are also provided. Accordingly, the invention provides methods of using PI3K? inhibitory compounds to inhibit PI3K?-mediated processes in vitro and in vivo.Type: ApplicationFiled: February 17, 2012Publication date: July 5, 2012Applicant: ICOS CORPORATIONInventors: Chanchal Sadhu, Ken Dick, Jennifer Treiberg, C. Gregory Sowell, Edward A. Kesicki, Amy Oliver
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Publication number: 20120138911Abstract: A biscarbazole derivative of the invention is represented by a formula (1A) or (1B) below. In the formula (1A) or (1B): A1 represents a substituted or unsubstituted nitrogen-containing heterocyclic group having 1 to 30 ring carbon atoms; A2 represents a substituted or unsubstituted aromatic hydrocarbon group having 6 to 30 ring carbon atoms, or substituted or unsubstituted nitrogen-containing heterocyclic group having 1 to 30 ring carbon atoms; X1 and X2 each are a linking group; Y1 to Y4 each represent a substituent; p and q represent an integer of 1 to 4; and r and s represent an integer of 1 to 3.Type: ApplicationFiled: February 14, 2012Publication date: June 7, 2012Inventors: Tetsuya Inoue, Mitsunori Ito, Kei Yoshida, Kumiko Hibino, Kazuki Nishimura, Toshinari Ogiwara, Kiyoshi Ikeda
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Publication number: 20120135986Abstract: This invention relates to compounds of the general formula: in which the variable groups are as defined herein, and to their preparation and use.Type: ApplicationFiled: January 25, 2012Publication date: May 31, 2012Applicant: ARIAD Pharmaceuticals, Inc.Inventors: Dong Zou, Wei-Sheng Huang, R. Mathew Thomas, Jan Antionette C. Romero, Jiwei Qi, Yihan Wang, Xiaotian Zhu, William C. Shakespeare, Rajeswari Sundaramoorthi, Chester A. Metcalf, III, David C. Dalgarno, Tomi K. Sawyer