Plural -c(=x)- Groups Bonded Directly To The Piperazine Ring Patents (Class 544/387)
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Patent number: 5336800Abstract: Oxamides useful as dye intermediates have the formula ##STR1## where R.sup.1 and R.sup.2 are independently of each other hydrogen, C.sub.1 -C.sub.4 -alkyl or phenyl,X is hydroxyl, nitro or a radical of the formula --NR.sup.3 R.sup.4, where R.sup.3 is hydrogen or C.sub.1 -C.sub.4 -alkanoyl and R.sup.4 is hydrogen, C.sub.1 -C.sub.4 -alkyl or phenyl,Z is C.sub.2 -C.sub.8 -alkylene, substituted or unsubstituted phenylene or substituted or unsubstituted naphthylene, or X--Z and R.sup.1 are, together with the nitrogen atom joining them together, the radical of the formula ##STR2## where R.sup.3 is as defined above,L is a bridge member andY is vinyl or a radical of the formula --C.sub.2 H.sub.4 --A, where A is hydroxyl or a group which is detachable under alkaline reaction conditions.Type: GrantFiled: January 4, 1993Date of Patent: August 9, 1994Assignee: BASF AktiengesellschaftInventors: Bernd Siegel, Manfred Patsch, Knut Kessel
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Patent number: 5326762Abstract: Amides of the formula ##STR1## wherein R.sub.1 and R.sub.2 are independently heteroaryl, X-substituted heteroaryl, X-substituted phenyl, N-substituted triazinyl or N-substituted imidazolyl;and in addition, one of R.sub.1 and R.sub.2 can be as defined above and the other can be phenyl;R.sub.3 is an alkyl chain of 2 to 25 carbon atoms, saturated or unsaturated; an alkyl chain as defined substituted by one or more substituents selected from the group consisting of phenyl, X-substituted phenyl, heteroaryl and X-substituted heteroaryl; an alkyl chain as defined interrupted by one or more groups independently selected from the group consisting of --O--, --S--, --SO--, --SO.sub.2 --, --NH--, --N(lower alkyl)--, --C(O)--, phenylene, X-substituted phenylene, heteroarylene and X-substituted heteroarylene; or an interrupted alkyl chain as defined substituted by one or more substituents selected form the group consisting of phenyl, X-substituted phenyl, heteroaryl and X-substituted heteroaryl;R.sub.Type: GrantFiled: May 19, 1992Date of Patent: July 5, 1994Assignee: Schering CorporationInventors: John Clader, Sundeep Dugar, Timothy Kogan, Bradley Tait, Wayne Vaccaro
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Patent number: 5298505Abstract: Compounds characterized generally as ethynyl alanine amino diol compounds having a piperazinyl-terminated or a piperazinyl-alkylamino-terminated group and derivatives thereof are useful as renin inhibitors for the treatment of hypertension. Compounds of particular interest are those of Formula I ##STR1## wherein A is selected from CO and SO.sub.2 ; wherein X is selected from oxygen atom and methylene; wherein G is a piperazinyl group or is a piperazinyl-containing group of Formula II: ##STR2## wherein B is a piperazinyl group or a alkylene-bridged-piperazinyl group; wherein R.sub.1 is selected from hydrido, methyl, ethyl, isopropyl and n-propyl; wherein R.sub.2 is phenylmethyl; wherein each of R.sub.3 and R.sub.5 is hydrido; wherein R.sub.4 is selected from ##STR3## wherein V is selected from hydrido and methyl; wherein R.sub.6 is cyclohexylmethyl; wherein R.sub.Type: GrantFiled: August 14, 1992Date of Patent: March 29, 1994Assignee: G. D. Searle & Co.Inventor: Gunnar J. Hanson
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Patent number: 5292726Abstract: Diacylpiperazines of general structure ##STR1## are: angiotensin II (A-II) antagonists selective for the type 2 (AT.sub.2) subtype useful in the treatment of cerebrovascular, cognitive, and CNS disorders; tachykinin receptor antagonists useful in the treatment of inflammatory diseases and pain or migraine; and calcium channel blockers useful in the treatment of cardiovascular conditions such as angina, hypertension or ischemia.Type: GrantFiled: May 19, 1992Date of Patent: March 8, 1994Assignee: Merck & Co., Inc.Inventors: Wallace T. Ashton, Conrad P. Dorn, William J. Greenlee, Malcolm MacCoss, Sander G. Mills, Mu T. Wu
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Patent number: 5268003Abstract: An amido peroxyacid compound is provided having the formula: ##STR1## wherein R is selected from the group consisting of C.sub.1 -C.sub.12 alkylene, C.sub.5 -C.sub.12 cycloalkylene, C.sub.6 -C.sub.12 arylene and radical combinations thereof;R.sup.1 and R.sup.2 are independently selected from the group consisting of H, C.sub.1 -C.sub.16 alkyl and C.sub.6 -C.sub.12 aryl radicals and a radical that can form a C.sub.3 -C.sub.12 ring together with R.sup.3 and both nitrogens;R.sup.3 is selected from the group consisting of C.sub.1 -C.sub.12 alkylene, C.sub.5 -C.sub.12 cycloalkylene and C.sub.6 -C.sub.12 arylene radicals, and provided when R.sup.3 is arylene and when n' and m' are each zero, R is other than C.sub.5 alkylene;n and n' each are an integer chosen such that the sum thereof is 1;m and m' each are an integer chosen such that the sum thereof is 1; andM is selected from the group consisting of H, alkali metal, alkaline earth metal, ammonium, alkanolammonium cations and radicals and combinations thereof.Type: GrantFiled: March 31, 1992Date of Patent: December 7, 1993Assignee: Lever Brothers Company, Division of Conopco, Inc.Inventors: Janet L. Coope, Robert W. Humphreys, Stephen A. Madison
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Patent number: 5192766Abstract: Compounds of formula (I): ##STR1## wherein R.sup.1 and R.sup.2 is each --R.sup.5, --CH.dbd.CH--R.sup.5 or --C.tbd.C--R.sup.5, wherein R.sup.5 is optionally substituted aryl or aromatic heterocyclic; R.sup.3 is hydrogen, alkyl, cyano or --R.sup.5 ; X is oxygen or sulfur; A is 1,4-piperazin-1,4-diyl or a 1,4-homopiperazin-1,4-diyl; B' is alkylene, carbonyl, thiocarbonyl, sulfinyl or sulfonyl; and R.sup.4 is optionally substituted phenyl and pharmaceutically acceptable salts thereof have valuable PAF antagonist activity, and may be prepared by reacting a compound containing the piperazine or homopiperazine part of the molecular with a compound containing the other part of the molecule.Type: GrantFiled: August 28, 1991Date of Patent: March 9, 1993Assignee: Sankyo Company, LimitedInventors: Norio Nakamura, Nobuyuki Ohkawa, Takeshi Oshima, Masaaki Miyamoto, Yasuteru Iijima
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Patent number: 5120738Abstract: Compounds represented by general formula (I) below ##STR1## wherein R.sup.1 and R.sup.2, which are the same or different, each represent a hydrogen atom or a protective group for a hydroxyl group;R.sup.3 represents a saturated or unsaturated, linear, branched or cyclic, monovalent C.sub.5 .about.C.sub.25 -aliphatic hydrocarbon group which may be substituted with an aromatic group, or a group of formula ##STR2## where R.sup.4 represents a saturated or unsaturated, linear, branched or cyclic, monovalent C.sub.5 .about.C.sub.25 -aliphatic hydrocarbon group which may be substituted with an aromatic group, andR.sup.5 represents a hydrogen atom, or a saturated or unsaturated, linear, branched or cyclic, monovalent hydrovarbon group which may be substituted with an aromatic group;Q represents(a) a group of formula --X.sup.1 --A--Y.sup.1 --, where A represents a saturated or unsaturated, linear, branched or cyclic divalent C.sub.2 .about.C.sub.Type: GrantFiled: October 5, 1990Date of Patent: June 9, 1992Assignee: Fujirebio Inc.Inventors: Hiroshi Ikawa, Hajime Matsumoto, Nobuo Kobayashi, Jun Kusunoki
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Patent number: 5112973Abstract: A novel fluorine-containing acrylic acid derivative of the invention is represented by the formula:(CH.sub.2 .dbd.CF--CO).sub.p --A (I)wherein A is a residue derived from an organic compound having at least two active hydrogen atoms derived by removing at least two active hydrogen atoms, and p is an integer corresponding to the valency of the residue A, which is easily cured.Type: GrantFiled: September 13, 1989Date of Patent: May 12, 1992Assignee: Daikin Industries Ltd.Inventors: Shigeru Morita, Masahiko Oka
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Patent number: 5102911Abstract: HMG-CoA reductase inhibitors of formulae (I) and (II) are disclosed.Type: GrantFiled: July 6, 1990Date of Patent: April 7, 1992Assignee: Merck & Co, Inc.Inventors: Ta J. Lee, Wilbur J. Holtz
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Patent number: 5051504Abstract: Triphenylmethane dyes of the formula ##STR1## where each R.sup.1 is independently of the others hydrogen or substituted or unsubstituted C.sub.1 -C.sub.6 -alkyl, or two R.sup.1 radicals together with the nitrogen atom joining them form a heterocyclic radical,R.sup.2 and R.sup.5 is independently of the others hydrogen or C.sub.1 -C.sub.4 -alkyl,R.sup.3 and R.sup.4 is independently of the others hydrogen, C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -alkoxy or halogen,An.sup..crclbar. is one equivalent of an anion, andn is 1 or 2,preparable from piperazine derivatives as intermediates, are useful for coloring paper.Type: GrantFiled: May 10, 1990Date of Patent: September 24, 1991Assignee: BASF AktiengesellschaftInventors: Erwin Hahn, Walter Breitschaft, Udo Mayer, Gunter-Rudolf Schroeder
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Patent number: 5019576Abstract: This invention relates to piperazine derivatives of the general formula I ##STR1## wherein --(CH.sub.2).sub.n -- represents a straight or branched chain alkyl group having from n=1 to n=20 carbon atoms, and R represents a hydrogen atom, a branched alkyl group, a cycloalkyl group having from 5 to 10 carbon atoms, a phenyl group, optionally substituted by one or several chlorine atoms, methyl or methoxy groups, or straight or branched chain alkenyl groups having from 3 to 11 carbon atoms, to a preparation process of said compounds and to therapeutic compositions containing them as an active ingredient.Type: GrantFiled: April 9, 1990Date of Patent: May 28, 1991Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.)Inventors: Pierre Braquet, Eduardo Pirotzky, Jean-Jacques Godfroid, Francoise Heymans
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Patent number: 4997836Abstract: Novel trisubstituted piperazine compounds of the formula (I) and pharmaceutically acceptable salts thereof: ##STR1## wherein R.sup.1, R.sup.2 and R.sup.Type: GrantFiled: November 9, 1989Date of Patent: March 5, 1991Assignee: Takeda Chemical Industries, Ltd.Inventors: Hirosada Sugihara, Kohei Nishikawa
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Patent number: 4973756Abstract: An alpha-hydroxyl-alpha,alpha-di(inert-substituted)-gamma',delta'-yne ketone can be prepared by a procedure comprising contacting an acetylenic Grignard reagent with an alpha-hydroxyl-alpha,alpha-di(inert substituted)-alpha',beta'-ene ketone, and the alpha-hydroxyl-alpha,alpha-di(inert-substituted)-alpha',beta'-ene ketone can be prepared by a procedure comprising steps of contacting, first, an alkoxy allene with a lithium donating organic agent, second, product of the first step with a di(inert-substituted)ketone, and third, product of the second step with an acidic substance.Type: GrantFiled: August 21, 1989Date of Patent: November 27, 1990Assignee: Marion Laboratories, Inc.Inventors: Hans Wynberg, Wolter T. Hoeve, Gerrit A. Barf, Johannes N. Koek, David R. Borcherding
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Patent number: 4943578Abstract: Compounds are disclosed of formula (I) ##STR1## wherein R.sub.1 represents --COR.sub.4, --CO.sub.2 R.sub.4 or --COCO.sub.2 R.sub.4 (where R.sub.4 represents a hydrogen atom or an unsubstituted or substituted C.sub.1-10 hydrocarbon moiety);R.sub.2 and R.sub.3 are the same or different and are C.sub.1-6 alkyl or C.sub.3-6 alkenyl; or --NR.sub.2 R.sub.3 forms a 5-membered (optionally containing an oxygen atom adjacent to the nitrogen) or 6-membered ring, which ring optionally contains one unit of unsaturation and which is unsubstituted or substituted by optionally substituted methylidene, --COR.sub.5 (where R.sub.5 represents C.sub.1-6 alkyl, --OR.sub.6 or --NHR.sub.6 and R.sub.6 represents hydrogen, C.sub.1-6 alkyl, aryl, or ar(C.sub.1-6)alkyl, or N.dbd.NOR.sub.7 (where R.sub.7 represents C.sub.1-6 alkyl);X represents a direct bond, --CH.sub.2 -- or --CH.sub.2 O--;Ar represents a substituted phenyl moiety;and physiologically acceptable salts thereof.Type: GrantFiled: May 23, 1989Date of Patent: July 24, 1990Assignee: Glaxo Group LimitedInventors: Alan Naylor, Duncan B. Judd, Dearg S. Brown
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Patent number: 4927825Abstract: This invention relates to piperazine derivatives having the general formula I: ##STR1## wherein Y stands for ##STR2## and Z represents various substituents, to a preparation process of said compounds and to therapeutic compositions containing them as an active ingredient.Type: GrantFiled: October 6, 1989Date of Patent: May 22, 1990Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.)Inventors: Eduardo Pirotzky, Georges Dive, Jean-Jacques Godfroid, Francoise Heymans
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Patent number: 4923870Abstract: This invention relates to piperazine derivatives having the general formula I: ##STR1## wherein Y stands for ##STR2## and Z represents various substituents, to be a preparation process of said compounds and to therapeutic compositions containing them as an active ingredient.Type: GrantFiled: October 6, 1989Date of Patent: May 8, 1990Assignee: Societe de Conseils de Reserches et d'Applications ScientifiquesInventors: Pierre Braquet, Georges Dive, Jean-Jacques Godfroid, Francoise Heymans, Eduardo Pirotzky
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Patent number: 4898876Abstract: A benzopylpiperazine ester of the following formula: ##STR1## wherein A represents a single bond or an alkylene group, vinylene group, --O--alkylene group or methine group, R.sub.1 represents a bicyclic carbon ring residue which may be substituted with a lower alkyl group, lower alkoxy group, oxo group or nitro group or a halogen atom, or may be partially saturated; a fluorene residue which may contain an oxo group; a fluorenylidene group; an anthracene residue; a phenanthrene residue which may be substituted with a lower alkyl group, or may be partially saturated; a benzofuran residue or thianaphthene residue which may be substituted with a lower alkyl group or lower alkoxy group; a benzopyran residue or benzoazine residue which may be substituted with an oxo group or phenyl group and partially saturated; a phthalimide residue; a benzodiazine residue; an isozazole residue which may be substituted with a lower alkyl group or phenyl group; or an alkylene dioxybenzene residue or xanthene residue; and R.sub.Type: GrantFiled: November 12, 1985Date of Patent: February 6, 1990Assignee: Kowa Co., Ltd.Inventors: Setsuro Fujii, Eizou Hattori, Mitsuteru Hirata, Koichiro Watanabe, Kazuhiro Onogi, Masahiko Nagakura
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Patent number: 4895842Abstract: A phenylalanine derivative having the formula (I): ##STR1## where R.sup.1 and R.sup.2 are independently hydrogen provided that both R.sup.1 and R.sup.2 are not hydrogen at the same time;C.sub.1 -C.sub.8 alkyl which may be substituted with hydroxy, hydroxycarbonyl, C.sub.1 -C.sub.4 alkoxycarbonyl, C.sub.1 -C.sub.4 alkylmercapto, C.sub.1 -C.sub.4 alkoxy, carbamoyl, sulfamoyl, pyridyl, or phenyl which may further be substituted with nitro, C.sub.1 -C.sub.4 alkoxy, or halogen;C.sub.6 -C.sub.8 cycloalkyl which may be substituted with hydroxy, C.sub.1 -C.sub.4 alkoxy, hydroxylcarbonyl, C.sub.1 -C.sub.4 alkoxycarbonyl, or C.sub.1 -C.sub.4 alkyl;phenyl which may be substituted with halogen, nitro, trifluoromethyl, C.sub.1 -C.sub.4 alkoxy C.sub.1 C.sub.4 alkylmercapto, C.sub.1 -C.sub.4 alkylcarbonyl, phenylcarbonyl, hydroxycarbonyl, C.sub.1 -C.sub.4 alkoxycarbonyl, carbamoyl, sulfamoyl, amidino, pyridylcarbonyl, or C.sub.1 -C.sub.6 alkyl which may further be substituted with C.sub.1 -C.sub.Type: GrantFiled: September 29, 1986Date of Patent: January 23, 1990Assignees: Shosuke Okamoto, Showa Denko Kabushiki KaishaInventors: Shosuke Okamoto, Yoshio Okada, Akiko Okunomiya, Taketoshi Naito, Yoshio Kimura, Morihiko Yamada, Norio Ohno, Yasuhiro Katsuura, Yumi Seki
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Patent number: 4895847Abstract: Novel 2,3-dihydro-1H-indene derivatives and salts thereof represented by the general formula (1), ##STR1## [wherein R.sup.1 and R.sup.2 are each a hydrogen atom, a lower alkyl group, a phenyl group which may have halogen atoms and/or alkyl groups as the substituents on the phenyl ring; R.sup.3 is a halogen atom or a lower alkyl group; R.sup.4 is a hydrogen atom, a halogen atom, a phenyl-lower alkyl group, a cycloalkyl-lower alkyl group or the like; R.sup.5 is a hydroxyimino group, an alkylamino group or a group of the formula --NHR.sup.8 (wherein R.sup.8 is a hydrogen atom, a halogen-substituted lower alkanoyl group or the like); R.sup.6 is a hydrogen atom or a phenyl group; and R.sup.7 is a hydrogen atom or a lower alkyl group].Type: GrantFiled: September 21, 1988Date of Patent: January 23, 1990Assignee: Otsuka Pharmaceutical Co., Ltd.Inventors: Yasuo Oshiro, Hiraki Ueda, Kazuyuki Nakagawa
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Patent number: 4880809Abstract: Novel 1,4-disubstituted piperazine compounds represented by the formula (I): ##STR1## wherein A is a condensed polycyclic hydrocarbon group;R is a phenyl group substituted with a lower alkoxy group;X is methylene group, carbonyl group or thiocarbonyl group;and m is 2 or 3, and their saltsare useful as a platelet activating factor antagonist.Type: GrantFiled: March 14, 1988Date of Patent: November 14, 1989Assignee: Takeda Chemical Industries, Ltd.Inventors: Hirosada Sugihara, Katsumi Itoh, Kohei Nishikawa
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Patent number: 4866177Abstract: A N-alkyl amide derivative is synthesized in one-step by reacting an olefin, nitrogen-containing compound and carbon monoxide with a catalyst comprising a rhodium-containing compound in the presence of water at a pressure of at least 500 psi and a temperature of at least 50.degree. C.Type: GrantFiled: November 24, 1986Date of Patent: September 12, 1989Assignee: Texaco Inc.Inventor: Jiang-Jen Lin
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Patent number: 4861885Abstract: The present invention relates to amides of formula I ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 are independently hydrogen or methyl, m is 1 to 5 and n is 1 to 5 and R.sup.4 is --NH.sub.2 or is derived from a mono- to pentavalent amine.Intermediates of formula VIII ##STR2## wherein R.sup.1, R.sup.2, R.sup.3 and m are as defined above and X is a carboxylic acid or acid ester group, --COCl, --COBr, --CHO or --CN, are also described.The compounds of formula I can be polymerized thermally. They are suitable for the preparation of adhesives, matrix resins or electrical insulating materials.Type: GrantFiled: December 8, 1986Date of Patent: August 29, 1989Assignee: Ciba-Geigy CorporationInventors: Andreas Kramer, Roland Darms
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Patent number: 4760179Abstract: Substituted aminoxy propionamide derivatives corrsponding to the formula ##STR1## said derivatives being useful as color improvers and stabilizers in various polymeric substrates.Type: GrantFiled: April 4, 1986Date of Patent: July 26, 1988Assignee: Ciba-Geigy CorporationInventor: Ramanathan Ravichandran
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Patent number: 4758652Abstract: A process for preparing oligomers and telechels of poly(carboxy-piperazine) and new oligomers the telechels of poly(carboxy-piperazine), wherein the process involves condensation of piperazine or piperazine-N-carboxylic acid esters or their reaction with piperazine or piperidine derivatives to form an intermediate which is reacted with diphenyl carbonate in the presence of a tertiary amine.Type: GrantFiled: November 17, 1986Date of Patent: July 19, 1988Assignee: Bayer AGInventors: Walter Heitz, Reinhold Schwalm
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Patent number: 4746737Abstract: Novel benzoyl esters of the following formula (I), and acid addition salts thereof, ##STR1## in which R.sub.1 and R.sub.2 are the same or different and represent a hydrogen atom or a lower alkoxy group, A represents a single bond, a linear or branched lower alkylene group, a lower alkenylene group, R.sub.3 and R.sub.4 are the same or different and represent a hydrogen atom or a lower alkyl group, or R.sub.3 and R.sub.4 join together to form a lower alkylene group, R.sub.5 represents a group of the formula, --X--(CO).sub.Type: GrantFiled: July 16, 1986Date of Patent: May 24, 1988Assignee: Kowa Co., Ltd.Inventors: Setsuro Fujii, Eizou Hattori, Mitsuteru Hirata, Koichiro Watanabe, Tomio Ohta, Nobuo Yokoo, Masahiko Nagakura
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Patent number: 4719301Abstract: The invention is a process for the preparation of such 3-halo-2-hydroxyalkyl carbamates which comprises contacting an epihalohydrin carbonate with a secondary amine-containing compound, wherein the secondary amine has a pKa at which the secondary amine will react with the epihalohydrin carbonate and which does not catalyze the formation of unwanted by-products, in a polar organic solvent under conditions such that a 3-halo-2-hydroxyalkyl carbamate, wherein the carbamate nitrogen is tertiary, is prepared.Type: GrantFiled: September 4, 1986Date of Patent: January 12, 1988Assignee: The Dow Chemical CompanyInventor: Joseph W. Hanafin
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Patent number: 4673700Abstract: Amide substituted benzylhydroxylamine derivatives are effective in stabilizing polyolefin compositions containing a stabilizer or mixture of stabilizers selected from the group consisting of the phenolic antioxidants, the hindered amine light stabilizers, the alkylated hydroxybenzoate light stabilizers, the ultraviolet light absorbers, the organic phosphorus compounds, the alkaline metal salts of fatty acids and the thiosynergists, against degradation upon high temperature extrusion, exposure to the combustion products of natural gas, gamma irradation or upon storage for extended periods. These amide substituted benzylhydroxylamine derivatives exhibit resistance to loss or extraction during processing and in end-use applications.Type: GrantFiled: November 21, 1985Date of Patent: June 16, 1987Assignee: Ciba-Geigy CorporationInventors: Ramanathan Ravichandran, Thomas E. Snead
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Patent number: 4670434Abstract: This invention relates to compounds of the formula ##STR1## and the pharmaceutically acceptable acid addition salts thereof wherein the various substituents are defined herein. These compounds are cyclic AMP phosphodiesterase inhibitors useful as antithrombotic and inotropic agents in mammals.Type: GrantFiled: November 14, 1985Date of Patent: June 2, 1987Assignee: Syntex (U.S.A.) Inc.Inventor: Michael C. Venuti
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Patent number: 4629791Abstract: The invention is a compound which comprises one or more 3-halo-2-hydroxyalkyl carbamate moieties; wherein the carbamate nitrogen is tertiary. In preferred embodiments, the carbamate nitrogen is tertiary, and the carbamate nitrogen is further substituted by an alicyclic or aliphatic moiety or is part of a heterocyclic ring, wherein the heterocyclic ring can contain an oxygen or sulfur atom or may contain another tertiary 3-halo-2-hydroxyalkyl carbamate moiety; or wherein two or more of such 3-halo-2-hydroxyalkyl carbamates are linked by an aliphatic or alicyclic moiety.Type: GrantFiled: August 9, 1984Date of Patent: December 16, 1986Assignee: The Dow Chemical CompanyInventor: Joseph W. Hanafin
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Patent number: 4565866Abstract: The instant invention relates to a process for the preparation of formamides in which ammonia, a primary or a secondary amine is reacted with carbon monoxide at an elevated temperature and pressure in the presence of a mixture consisting of a phenol and a phenate salt from the group consisting of an alkali metal phenate and an alkaline earth metal phenate, said phenol and said phenate salt each having the radical: ##STR1## wherein R is selected from the group consisting of an alkyl radical having from 3 to 18 carbon atoms and a hydroxyaryl radical of the formula: ##STR2## in which R' is an alkylene group having from 2 to 5 carbon atoms and in which x has a value of 1 to 2 when R is said alkyl radical and x has a value of 1 when R is said hydroxyaryl radical.Type: GrantFiled: January 24, 1984Date of Patent: January 21, 1986Assignee: Texaco Inc.Inventors: Roger G. Duranleau, John F. Knifton, George P. Speranza
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Patent number: 4561451Abstract: This invention provides smoking compositions which contain a diacylpiperazine additive such as 1,4-(2-methylpropionyl)-2,3,5,6-tetramethylpiperazine: ##STR1## The preferred diacylpiperazine additives impart enhanced flavor response and smoothness.Type: GrantFiled: August 23, 1982Date of Patent: December 31, 1985Assignee: Philip Morris IncorporatedInventors: William B. Edwards, III, Yoram Houminer
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Patent number: 4455309Abstract: New halo-methyl-thioamino-benzamides of the formula ##STR1## wherein X.sup.1 represents optionally substituted alkylene, arylene or alkarylene, it being possible for the alkylene and/or arylene and/or alkarylene groups to be linked via oxo, thio, carboxo, carboxamido or sulphoxo groups,A.sup.1 denotes the radical ##STR2## wherein Hal represents halogen,the various substituents R can be identical or different and represent hydrogen, optionally substituted alkyl or aryl or a substituted R, in the case where X.sup.1 denotes optionally substituted ethylene and m.sup.1 and n.sup.1 represent the number 1, forms an ethylene bridge by being linked to a second R,m.sup.1 denotes an integer from 1 to 5 and indicates the number of linkages of ##STR3## with X.sup.1, and n.sup.1 denotes a number from 1 to 100;a process for preparing the same by reaction of a halo-methyl-thioamino-benzoic acid fluoride with an amine in the presence of a base and the use of such halo-methyl-thioamino-benzamides as microbicidal agents.Type: GrantFiled: August 20, 1981Date of Patent: June 19, 1984Assignee: Bayer AktiengesellschaftInventors: Helmut Ritter, Wilfried Paulus, Engelbert Kuhle, Hermann Genth
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Patent number: 4426380Abstract: The invention relates to novel furans, especially benzofuranones of the general formula ##STR1## in which R.sub.1 represents hydrogen or an aliphatic radical, R.sub.2 represents an amino group di-substituted by a divalent hydrocarbon radical, and the aromatic ring A may be additionally substituted, and their salts and/or isomers, processes for the manufacture of compounds of the formula (I) and their salts and isomers, pharmaceutical preparations containing these compounds, and their use as the active ingredients of medicaments as anti-inflammatory agents, analgesics or light-screening agents and/or for the manufacture of pharmaceutical preparations.Type: GrantFiled: October 21, 1982Date of Patent: January 17, 1984Assignee: Ciba-Geigy CorporationInventors: Paul Wenk, Werner Breitenstein, Marcus Baumann
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Patent number: 4421915Abstract: Compounds useful in making crosslinkable polymers having the formula (I): ##STR1## wherein R is hydrogen or methyl; R.sup.1 is cyano or ##STR2## wherein R.sup.2 is alkyl; Z is --X--R.sup.3 --X-- or ##STR3## wherein each --X-- is --O-- or --NR.sup.4 --, provided at least one --X-- is --NR.sup.4 -- wherein R.sup.4 is hydrogen or alkyl R.sup.3 is divalent hydrocarbon and D.sub.1 and D.sub.2 together are the carbon atoms necessary to complete a 5 to 7 membered ring. These compounds can be homopolymerized or copolymerized with each other or with other polymerizable ethylenically unsaturated monomers to give crosslinkable polymers. Such polymers can be purified by conventional purification techniques such as dialysis, diafiltration, ultrafiltration without losing their capability of crosslinking. The resulting purified polymers are particularly useful in photographic materials as gelatin extenders, binders or polymeric color couplers.Type: GrantFiled: April 19, 1982Date of Patent: December 20, 1983Assignee: Eastman Kodak CompanyInventors: Ignazio S. Ponticello, Kenneth R. Hollister, Richard C. Tuites
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Patent number: 4420482Abstract: The present invention concerns compounds of the general formula ##STR1## wherein X represents a direct linkage or a linear or branched oxyalkyl group containing one or more carbon atoms, as well as pharmaceutically acceptable salts of such compounds wherein X represents an oxyalkyl group, methods for their preparation by reaction of either piperazine or of its 1,4-bis-hydroxyalkyl derivatives with activated derivatives of acetylsalicylic acid such as halogenides, symmetric or mixed anhydrides, or with a haloalkylester of acetylsalicylic acid, and related pharmaceutical compositions having use as antipyretic, analgesic, anti-inflammatory and anti-histaminic agents.Type: GrantFiled: November 19, 1981Date of Patent: December 13, 1983Assignee: Selvi & C. S.p.A.Inventors: Carlo Milani, Giovanni M. Carminati, Attilio Sovera
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Patent number: 4329462Abstract: Carboxylic amides can be produced simply and in good yield by reacting primary alcohols with at least one compound selected from ammonia, primary amines, and secondary amines, in the presence of a molecular oxygen-containing gas and a palladium or platinum catalyst under oxidative conditions.Type: GrantFiled: April 3, 1980Date of Patent: May 11, 1982Assignee: Asahi Kasei Kogyo Kabushiki KaishaInventors: Nobuhiro Tamura, Yohei Fukuoka, Joji Nishikido, Setsuo Yamamatsu, Yoshio Suzuki
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Patent number: 4312869Abstract: Biphenylalkylene-thiazolyl-piperazines of the formula ##STR1## wherein Ar and A are as defined herein, e.g., 1-[4-(4-phenylsulfinylbenzyl)-2-thiazolyl]piperazine, and 1-[4-(4-biphenylylmethyl)-2-thiazolyl]piperazine, and their physiologically tolerable salts are provided. These compounds are useful as medicines for the treatment of inflammation with an immunological component, and are useful as hypolipemic and hypocholesterolemic agents and to assist lowering of lipid and cholesterol content in the blood.Type: GrantFiled: September 11, 1980Date of Patent: January 26, 1982Assignee: Science Union et CieInventors: Gilbert Regnier, Jacques Bure
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Patent number: 4259476Abstract: Novel heterocyclic anthracycline compounds having antitumor activity against murine P388 leukemia in mice.Type: GrantFiled: April 2, 1979Date of Patent: March 31, 1981Inventors: Andrew S. Kende, Howard Newman
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Patent number: 4243665Abstract: Compounds corresponding to the formula ##STR1## in which R' is a hydrogen atom or a methyl radical and R represents a radical ##STR2## in which Z is O, S, S.fwdarw.O, SO.sub.2 or NR.sub.1, in which R.sub.1 is a hydrogen atom or an alkyl, CONR.sub.2 R.sub.3, COOR.sub.2, COR.sub.2 or SO.sub.2 R.sub.2 radical, R.sub.2 and R.sub.3 each representing, independently of one another, a hydrogen atom, an alkyl radical having 1 to 4 carbon atoms, a phenyl radical or a CF.sub.3 radical, in the form of racemates or enantiomers if R' is CH.sub.3, and also, where appropriate, their addition salts with pharmaceutically acceptable acids.The compounds and salts are useful as anti-inflammatory agents, e.g. for treatment of arthritis. A process for preparing them and pharmaceutical compositions containing them are also claimed.Type: GrantFiled: November 21, 1978Date of Patent: January 6, 1981Assignee: SynthelaboInventors: Thomas A. Purcell, Braham Shroot, Daniel J. M. Galtier
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Patent number: 4189468Abstract: A cosmetic composition for the hair comprises at least one water-soluble crosslinked polymer obtained by crosslinking a polyamino-polyamide with a crosslinking agent, said polyamino-polyamide being prepared by the polycondensation of (a) an acidic compound selected from the group consisting of (i) organic dicarboxylic acid, (ii) ethylenically unsaturated aliphatic mono- or di-carboxylic acid, (iii) ester of said acids of (i) and (ii), and (iv) mixtures of (i), (ii) and (iii) on (b) a polyamine selected from the group consisting of bis-primary and mono- or bis-secondary polyalkylene polyamines, said polyamine (b) being replaceable by a member selected from the group consisting of (1) 0-20 mole percent hexamethylene diamine, (2) 0-40 mole percent bis-primary amine and (3) 0-40 mole percent bis-secondary amine, said crosslinking agent being selected from the group consisting of (a') simple bi-functional compounds selected from bis-halohydrins, bis-azetidinium, bis-haloacyl diamine and alkyl bis-halides, (b') oliType: GrantFiled: February 27, 1978Date of Patent: February 19, 1980Assignee: L'OrealInventors: Guy Vanlerberghe, Henri Sebag, Jean-Francois Grollier, Alexandre Zysman
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Patent number: 4134765Abstract: A vinylsulphone compound of the formula ##STR1## is provided. This compound is useful as cross-linking agent for hydrophilic colloids, especially for gelatin which is in the form of layers of photographic materials.Type: GrantFiled: January 11, 1978Date of Patent: January 16, 1979Assignee: Ciba-Geigy AGInventor: Norman A. Smith
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Patent number: 4101550Abstract: The compounds are esters and amides of trialkylhydroxyphenylalkanoic acid having the formula ##STR1## wherein R, R.sup.1 and R.sup.2 are independently lower alkyl or cycloalkyl groups, R.sup.3 is hydrogen, alkyl, cycloalkyl, alkylene, phenyl, phenyl substituted by alkyl groups, alkylthioethyl, thiobis-alkylene, alkyleneoxyalkylene, polyoxyalkylene or a polyvalent cyclic or acyclic hydrocarbon radical, R.sup.4 is hydrogen, lower alkyl, cycloalkyl, R.sup.5 is hydrogen, alkyl, phenyl, phenyl substituted with alkyl groups, alkylene, polyoxyalkylene or polyvalent cyclic or acyclic hydrocarbon radical, A is lower alkylene, m is 1 to 4 and n is 1 to 6.The ester compounds of this invention are prepared via usual esterification procedures from a suitable alcohol and an acid of the formula I ##STR2## or an acid halide or acid anhydride thereof.Type: GrantFiled: April 22, 1977Date of Patent: July 18, 1978Assignee: Ciba-Geigy CorporationInventor: John D. Spivack
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Patent number: 4093618Abstract: Ester and amides having the formula ##STR1## wherein R, R.sup.1 and R.sup.2 are independently lower alkyl or cycloalkyl groups, R.sup.3 is hydrogen, alkyl, cycloalkyl, alkylene, phenyl, phenyl substituted by alkyl groups, alkylthioethyl, thiobis-alkylene, alkyleneoxyalkylene, polyoxyalkylene or a polyvalent cyclic or acyclic hydrocarbon radical, R.sup.4 is hydrogen, lower alkyl, cycloalkyl, R.sup.5 is hydrogen, alkyl, phenyl, phenyl subsstituted by alkyl groups, alkylene, a polyvalent cyclic or acyclic hydrocarbon radical or alkyleneoxyalkylene, A is lower alkylene, m is 1 to 4 and n is 1 to 6.Type: GrantFiled: June 7, 1976Date of Patent: June 6, 1978Assignee: Ciba-Geigy CorporationInventors: John D. Spivack, Martin Dexter
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Patent number: 4088648Abstract: A vinylsulphone compound of the formula ##STR1## is provided. This compound is useful as cross-linking agent for hydrophilic colloids, especially for gelatin which is in the form of layers of photographic materials.Type: GrantFiled: October 22, 1976Date of Patent: May 9, 1978Assignee: Ciba-Geigy AGInventor: Norman Alfred Smith