Plural -c(=x)- Groups Bonded Directly To The Piperazine Ring Patents (Class 544/387)
  • Patent number: 5336800
    Abstract: Oxamides useful as dye intermediates have the formula ##STR1## where R.sup.1 and R.sup.2 are independently of each other hydrogen, C.sub.1 -C.sub.4 -alkyl or phenyl,X is hydroxyl, nitro or a radical of the formula --NR.sup.3 R.sup.4, where R.sup.3 is hydrogen or C.sub.1 -C.sub.4 -alkanoyl and R.sup.4 is hydrogen, C.sub.1 -C.sub.4 -alkyl or phenyl,Z is C.sub.2 -C.sub.8 -alkylene, substituted or unsubstituted phenylene or substituted or unsubstituted naphthylene, or X--Z and R.sup.1 are, together with the nitrogen atom joining them together, the radical of the formula ##STR2## where R.sup.3 is as defined above,L is a bridge member andY is vinyl or a radical of the formula --C.sub.2 H.sub.4 --A, where A is hydroxyl or a group which is detachable under alkaline reaction conditions.
    Type: Grant
    Filed: January 4, 1993
    Date of Patent: August 9, 1994
    Assignee: BASF Aktiengesellschaft
    Inventors: Bernd Siegel, Manfred Patsch, Knut Kessel
  • Patent number: 5326762
    Abstract: Amides of the formula ##STR1## wherein R.sub.1 and R.sub.2 are independently heteroaryl, X-substituted heteroaryl, X-substituted phenyl, N-substituted triazinyl or N-substituted imidazolyl;and in addition, one of R.sub.1 and R.sub.2 can be as defined above and the other can be phenyl;R.sub.3 is an alkyl chain of 2 to 25 carbon atoms, saturated or unsaturated; an alkyl chain as defined substituted by one or more substituents selected from the group consisting of phenyl, X-substituted phenyl, heteroaryl and X-substituted heteroaryl; an alkyl chain as defined interrupted by one or more groups independently selected from the group consisting of --O--, --S--, --SO--, --SO.sub.2 --, --NH--, --N(lower alkyl)--, --C(O)--, phenylene, X-substituted phenylene, heteroarylene and X-substituted heteroarylene; or an interrupted alkyl chain as defined substituted by one or more substituents selected form the group consisting of phenyl, X-substituted phenyl, heteroaryl and X-substituted heteroaryl;R.sub.
    Type: Grant
    Filed: May 19, 1992
    Date of Patent: July 5, 1994
    Assignee: Schering Corporation
    Inventors: John Clader, Sundeep Dugar, Timothy Kogan, Bradley Tait, Wayne Vaccaro
  • Patent number: 5298505
    Abstract: Compounds characterized generally as ethynyl alanine amino diol compounds having a piperazinyl-terminated or a piperazinyl-alkylamino-terminated group and derivatives thereof are useful as renin inhibitors for the treatment of hypertension. Compounds of particular interest are those of Formula I ##STR1## wherein A is selected from CO and SO.sub.2 ; wherein X is selected from oxygen atom and methylene; wherein G is a piperazinyl group or is a piperazinyl-containing group of Formula II: ##STR2## wherein B is a piperazinyl group or a alkylene-bridged-piperazinyl group; wherein R.sub.1 is selected from hydrido, methyl, ethyl, isopropyl and n-propyl; wherein R.sub.2 is phenylmethyl; wherein each of R.sub.3 and R.sub.5 is hydrido; wherein R.sub.4 is selected from ##STR3## wherein V is selected from hydrido and methyl; wherein R.sub.6 is cyclohexylmethyl; wherein R.sub.
    Type: Grant
    Filed: August 14, 1992
    Date of Patent: March 29, 1994
    Assignee: G. D. Searle & Co.
    Inventor: Gunnar J. Hanson
  • Patent number: 5292726
    Abstract: Diacylpiperazines of general structure ##STR1## are: angiotensin II (A-II) antagonists selective for the type 2 (AT.sub.2) subtype useful in the treatment of cerebrovascular, cognitive, and CNS disorders; tachykinin receptor antagonists useful in the treatment of inflammatory diseases and pain or migraine; and calcium channel blockers useful in the treatment of cardiovascular conditions such as angina, hypertension or ischemia.
    Type: Grant
    Filed: May 19, 1992
    Date of Patent: March 8, 1994
    Assignee: Merck & Co., Inc.
    Inventors: Wallace T. Ashton, Conrad P. Dorn, William J. Greenlee, Malcolm MacCoss, Sander G. Mills, Mu T. Wu
  • Patent number: 5268003
    Abstract: An amido peroxyacid compound is provided having the formula: ##STR1## wherein R is selected from the group consisting of C.sub.1 -C.sub.12 alkylene, C.sub.5 -C.sub.12 cycloalkylene, C.sub.6 -C.sub.12 arylene and radical combinations thereof;R.sup.1 and R.sup.2 are independently selected from the group consisting of H, C.sub.1 -C.sub.16 alkyl and C.sub.6 -C.sub.12 aryl radicals and a radical that can form a C.sub.3 -C.sub.12 ring together with R.sup.3 and both nitrogens;R.sup.3 is selected from the group consisting of C.sub.1 -C.sub.12 alkylene, C.sub.5 -C.sub.12 cycloalkylene and C.sub.6 -C.sub.12 arylene radicals, and provided when R.sup.3 is arylene and when n' and m' are each zero, R is other than C.sub.5 alkylene;n and n' each are an integer chosen such that the sum thereof is 1;m and m' each are an integer chosen such that the sum thereof is 1; andM is selected from the group consisting of H, alkali metal, alkaline earth metal, ammonium, alkanolammonium cations and radicals and combinations thereof.
    Type: Grant
    Filed: March 31, 1992
    Date of Patent: December 7, 1993
    Assignee: Lever Brothers Company, Division of Conopco, Inc.
    Inventors: Janet L. Coope, Robert W. Humphreys, Stephen A. Madison
  • Patent number: 5192766
    Abstract: Compounds of formula (I): ##STR1## wherein R.sup.1 and R.sup.2 is each --R.sup.5, --CH.dbd.CH--R.sup.5 or --C.tbd.C--R.sup.5, wherein R.sup.5 is optionally substituted aryl or aromatic heterocyclic; R.sup.3 is hydrogen, alkyl, cyano or --R.sup.5 ; X is oxygen or sulfur; A is 1,4-piperazin-1,4-diyl or a 1,4-homopiperazin-1,4-diyl; B' is alkylene, carbonyl, thiocarbonyl, sulfinyl or sulfonyl; and R.sup.4 is optionally substituted phenyl and pharmaceutically acceptable salts thereof have valuable PAF antagonist activity, and may be prepared by reacting a compound containing the piperazine or homopiperazine part of the molecular with a compound containing the other part of the molecule.
    Type: Grant
    Filed: August 28, 1991
    Date of Patent: March 9, 1993
    Assignee: Sankyo Company, Limited
    Inventors: Norio Nakamura, Nobuyuki Ohkawa, Takeshi Oshima, Masaaki Miyamoto, Yasuteru Iijima
  • Patent number: 5120738
    Abstract: Compounds represented by general formula (I) below ##STR1## wherein R.sup.1 and R.sup.2, which are the same or different, each represent a hydrogen atom or a protective group for a hydroxyl group;R.sup.3 represents a saturated or unsaturated, linear, branched or cyclic, monovalent C.sub.5 .about.C.sub.25 -aliphatic hydrocarbon group which may be substituted with an aromatic group, or a group of formula ##STR2## where R.sup.4 represents a saturated or unsaturated, linear, branched or cyclic, monovalent C.sub.5 .about.C.sub.25 -aliphatic hydrocarbon group which may be substituted with an aromatic group, andR.sup.5 represents a hydrogen atom, or a saturated or unsaturated, linear, branched or cyclic, monovalent hydrovarbon group which may be substituted with an aromatic group;Q represents(a) a group of formula --X.sup.1 --A--Y.sup.1 --, where A represents a saturated or unsaturated, linear, branched or cyclic divalent C.sub.2 .about.C.sub.
    Type: Grant
    Filed: October 5, 1990
    Date of Patent: June 9, 1992
    Assignee: Fujirebio Inc.
    Inventors: Hiroshi Ikawa, Hajime Matsumoto, Nobuo Kobayashi, Jun Kusunoki
  • Patent number: 5112973
    Abstract: A novel fluorine-containing acrylic acid derivative of the invention is represented by the formula:(CH.sub.2 .dbd.CF--CO).sub.p --A (I)wherein A is a residue derived from an organic compound having at least two active hydrogen atoms derived by removing at least two active hydrogen atoms, and p is an integer corresponding to the valency of the residue A, which is easily cured.
    Type: Grant
    Filed: September 13, 1989
    Date of Patent: May 12, 1992
    Assignee: Daikin Industries Ltd.
    Inventors: Shigeru Morita, Masahiko Oka
  • Patent number: 5102911
    Abstract: HMG-CoA reductase inhibitors of formulae (I) and (II) are disclosed.
    Type: Grant
    Filed: July 6, 1990
    Date of Patent: April 7, 1992
    Assignee: Merck & Co, Inc.
    Inventors: Ta J. Lee, Wilbur J. Holtz
  • Patent number: 5051504
    Abstract: Triphenylmethane dyes of the formula ##STR1## where each R.sup.1 is independently of the others hydrogen or substituted or unsubstituted C.sub.1 -C.sub.6 -alkyl, or two R.sup.1 radicals together with the nitrogen atom joining them form a heterocyclic radical,R.sup.2 and R.sup.5 is independently of the others hydrogen or C.sub.1 -C.sub.4 -alkyl,R.sup.3 and R.sup.4 is independently of the others hydrogen, C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -alkoxy or halogen,An.sup..crclbar. is one equivalent of an anion, andn is 1 or 2,preparable from piperazine derivatives as intermediates, are useful for coloring paper.
    Type: Grant
    Filed: May 10, 1990
    Date of Patent: September 24, 1991
    Assignee: BASF Aktiengesellschaft
    Inventors: Erwin Hahn, Walter Breitschaft, Udo Mayer, Gunter-Rudolf Schroeder
  • Patent number: 5019576
    Abstract: This invention relates to piperazine derivatives of the general formula I ##STR1## wherein --(CH.sub.2).sub.n -- represents a straight or branched chain alkyl group having from n=1 to n=20 carbon atoms, and R represents a hydrogen atom, a branched alkyl group, a cycloalkyl group having from 5 to 10 carbon atoms, a phenyl group, optionally substituted by one or several chlorine atoms, methyl or methoxy groups, or straight or branched chain alkenyl groups having from 3 to 11 carbon atoms, to a preparation process of said compounds and to therapeutic compositions containing them as an active ingredient.
    Type: Grant
    Filed: April 9, 1990
    Date of Patent: May 28, 1991
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.)
    Inventors: Pierre Braquet, Eduardo Pirotzky, Jean-Jacques Godfroid, Francoise Heymans
  • Patent number: 4997836
    Abstract: Novel trisubstituted piperazine compounds of the formula (I) and pharmaceutically acceptable salts thereof: ##STR1## wherein R.sup.1, R.sup.2 and R.sup.
    Type: Grant
    Filed: November 9, 1989
    Date of Patent: March 5, 1991
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Hirosada Sugihara, Kohei Nishikawa
  • Patent number: 4973756
    Abstract: An alpha-hydroxyl-alpha,alpha-di(inert-substituted)-gamma',delta'-yne ketone can be prepared by a procedure comprising contacting an acetylenic Grignard reagent with an alpha-hydroxyl-alpha,alpha-di(inert substituted)-alpha',beta'-ene ketone, and the alpha-hydroxyl-alpha,alpha-di(inert-substituted)-alpha',beta'-ene ketone can be prepared by a procedure comprising steps of contacting, first, an alkoxy allene with a lithium donating organic agent, second, product of the first step with a di(inert-substituted)ketone, and third, product of the second step with an acidic substance.
    Type: Grant
    Filed: August 21, 1989
    Date of Patent: November 27, 1990
    Assignee: Marion Laboratories, Inc.
    Inventors: Hans Wynberg, Wolter T. Hoeve, Gerrit A. Barf, Johannes N. Koek, David R. Borcherding
  • Patent number: 4943578
    Abstract: Compounds are disclosed of formula (I) ##STR1## wherein R.sub.1 represents --COR.sub.4, --CO.sub.2 R.sub.4 or --COCO.sub.2 R.sub.4 (where R.sub.4 represents a hydrogen atom or an unsubstituted or substituted C.sub.1-10 hydrocarbon moiety);R.sub.2 and R.sub.3 are the same or different and are C.sub.1-6 alkyl or C.sub.3-6 alkenyl; or --NR.sub.2 R.sub.3 forms a 5-membered (optionally containing an oxygen atom adjacent to the nitrogen) or 6-membered ring, which ring optionally contains one unit of unsaturation and which is unsubstituted or substituted by optionally substituted methylidene, --COR.sub.5 (where R.sub.5 represents C.sub.1-6 alkyl, --OR.sub.6 or --NHR.sub.6 and R.sub.6 represents hydrogen, C.sub.1-6 alkyl, aryl, or ar(C.sub.1-6)alkyl, or N.dbd.NOR.sub.7 (where R.sub.7 represents C.sub.1-6 alkyl);X represents a direct bond, --CH.sub.2 -- or --CH.sub.2 O--;Ar represents a substituted phenyl moiety;and physiologically acceptable salts thereof.
    Type: Grant
    Filed: May 23, 1989
    Date of Patent: July 24, 1990
    Assignee: Glaxo Group Limited
    Inventors: Alan Naylor, Duncan B. Judd, Dearg S. Brown
  • Patent number: 4927825
    Abstract: This invention relates to piperazine derivatives having the general formula I: ##STR1## wherein Y stands for ##STR2## and Z represents various substituents, to a preparation process of said compounds and to therapeutic compositions containing them as an active ingredient.
    Type: Grant
    Filed: October 6, 1989
    Date of Patent: May 22, 1990
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.)
    Inventors: Eduardo Pirotzky, Georges Dive, Jean-Jacques Godfroid, Francoise Heymans
  • Patent number: 4923870
    Abstract: This invention relates to piperazine derivatives having the general formula I: ##STR1## wherein Y stands for ##STR2## and Z represents various substituents, to be a preparation process of said compounds and to therapeutic compositions containing them as an active ingredient.
    Type: Grant
    Filed: October 6, 1989
    Date of Patent: May 8, 1990
    Assignee: Societe de Conseils de Reserches et d'Applications Scientifiques
    Inventors: Pierre Braquet, Georges Dive, Jean-Jacques Godfroid, Francoise Heymans, Eduardo Pirotzky
  • Patent number: 4898876
    Abstract: A benzopylpiperazine ester of the following formula: ##STR1## wherein A represents a single bond or an alkylene group, vinylene group, --O--alkylene group or methine group, R.sub.1 represents a bicyclic carbon ring residue which may be substituted with a lower alkyl group, lower alkoxy group, oxo group or nitro group or a halogen atom, or may be partially saturated; a fluorene residue which may contain an oxo group; a fluorenylidene group; an anthracene residue; a phenanthrene residue which may be substituted with a lower alkyl group, or may be partially saturated; a benzofuran residue or thianaphthene residue which may be substituted with a lower alkyl group or lower alkoxy group; a benzopyran residue or benzoazine residue which may be substituted with an oxo group or phenyl group and partially saturated; a phthalimide residue; a benzodiazine residue; an isozazole residue which may be substituted with a lower alkyl group or phenyl group; or an alkylene dioxybenzene residue or xanthene residue; and R.sub.
    Type: Grant
    Filed: November 12, 1985
    Date of Patent: February 6, 1990
    Assignee: Kowa Co., Ltd.
    Inventors: Setsuro Fujii, Eizou Hattori, Mitsuteru Hirata, Koichiro Watanabe, Kazuhiro Onogi, Masahiko Nagakura
  • Patent number: 4895842
    Abstract: A phenylalanine derivative having the formula (I): ##STR1## where R.sup.1 and R.sup.2 are independently hydrogen provided that both R.sup.1 and R.sup.2 are not hydrogen at the same time;C.sub.1 -C.sub.8 alkyl which may be substituted with hydroxy, hydroxycarbonyl, C.sub.1 -C.sub.4 alkoxycarbonyl, C.sub.1 -C.sub.4 alkylmercapto, C.sub.1 -C.sub.4 alkoxy, carbamoyl, sulfamoyl, pyridyl, or phenyl which may further be substituted with nitro, C.sub.1 -C.sub.4 alkoxy, or halogen;C.sub.6 -C.sub.8 cycloalkyl which may be substituted with hydroxy, C.sub.1 -C.sub.4 alkoxy, hydroxylcarbonyl, C.sub.1 -C.sub.4 alkoxycarbonyl, or C.sub.1 -C.sub.4 alkyl;phenyl which may be substituted with halogen, nitro, trifluoromethyl, C.sub.1 -C.sub.4 alkoxy C.sub.1 C.sub.4 alkylmercapto, C.sub.1 -C.sub.4 alkylcarbonyl, phenylcarbonyl, hydroxycarbonyl, C.sub.1 -C.sub.4 alkoxycarbonyl, carbamoyl, sulfamoyl, amidino, pyridylcarbonyl, or C.sub.1 -C.sub.6 alkyl which may further be substituted with C.sub.1 -C.sub.
    Type: Grant
    Filed: September 29, 1986
    Date of Patent: January 23, 1990
    Assignees: Shosuke Okamoto, Showa Denko Kabushiki Kaisha
    Inventors: Shosuke Okamoto, Yoshio Okada, Akiko Okunomiya, Taketoshi Naito, Yoshio Kimura, Morihiko Yamada, Norio Ohno, Yasuhiro Katsuura, Yumi Seki
  • Patent number: 4895847
    Abstract: Novel 2,3-dihydro-1H-indene derivatives and salts thereof represented by the general formula (1), ##STR1## [wherein R.sup.1 and R.sup.2 are each a hydrogen atom, a lower alkyl group, a phenyl group which may have halogen atoms and/or alkyl groups as the substituents on the phenyl ring; R.sup.3 is a halogen atom or a lower alkyl group; R.sup.4 is a hydrogen atom, a halogen atom, a phenyl-lower alkyl group, a cycloalkyl-lower alkyl group or the like; R.sup.5 is a hydroxyimino group, an alkylamino group or a group of the formula --NHR.sup.8 (wherein R.sup.8 is a hydrogen atom, a halogen-substituted lower alkanoyl group or the like); R.sup.6 is a hydrogen atom or a phenyl group; and R.sup.7 is a hydrogen atom or a lower alkyl group].
    Type: Grant
    Filed: September 21, 1988
    Date of Patent: January 23, 1990
    Assignee: Otsuka Pharmaceutical Co., Ltd.
    Inventors: Yasuo Oshiro, Hiraki Ueda, Kazuyuki Nakagawa
  • Patent number: 4880809
    Abstract: Novel 1,4-disubstituted piperazine compounds represented by the formula (I): ##STR1## wherein A is a condensed polycyclic hydrocarbon group;R is a phenyl group substituted with a lower alkoxy group;X is methylene group, carbonyl group or thiocarbonyl group;and m is 2 or 3, and their saltsare useful as a platelet activating factor antagonist.
    Type: Grant
    Filed: March 14, 1988
    Date of Patent: November 14, 1989
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Hirosada Sugihara, Katsumi Itoh, Kohei Nishikawa
  • Patent number: 4866177
    Abstract: A N-alkyl amide derivative is synthesized in one-step by reacting an olefin, nitrogen-containing compound and carbon monoxide with a catalyst comprising a rhodium-containing compound in the presence of water at a pressure of at least 500 psi and a temperature of at least 50.degree. C.
    Type: Grant
    Filed: November 24, 1986
    Date of Patent: September 12, 1989
    Assignee: Texaco Inc.
    Inventor: Jiang-Jen Lin
  • Patent number: 4861885
    Abstract: The present invention relates to amides of formula I ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 are independently hydrogen or methyl, m is 1 to 5 and n is 1 to 5 and R.sup.4 is --NH.sub.2 or is derived from a mono- to pentavalent amine.Intermediates of formula VIII ##STR2## wherein R.sup.1, R.sup.2, R.sup.3 and m are as defined above and X is a carboxylic acid or acid ester group, --COCl, --COBr, --CHO or --CN, are also described.The compounds of formula I can be polymerized thermally. They are suitable for the preparation of adhesives, matrix resins or electrical insulating materials.
    Type: Grant
    Filed: December 8, 1986
    Date of Patent: August 29, 1989
    Assignee: Ciba-Geigy Corporation
    Inventors: Andreas Kramer, Roland Darms
  • Patent number: 4760179
    Abstract: Substituted aminoxy propionamide derivatives corrsponding to the formula ##STR1## said derivatives being useful as color improvers and stabilizers in various polymeric substrates.
    Type: Grant
    Filed: April 4, 1986
    Date of Patent: July 26, 1988
    Assignee: Ciba-Geigy Corporation
    Inventor: Ramanathan Ravichandran
  • Patent number: 4758652
    Abstract: A process for preparing oligomers and telechels of poly(carboxy-piperazine) and new oligomers the telechels of poly(carboxy-piperazine), wherein the process involves condensation of piperazine or piperazine-N-carboxylic acid esters or their reaction with piperazine or piperidine derivatives to form an intermediate which is reacted with diphenyl carbonate in the presence of a tertiary amine.
    Type: Grant
    Filed: November 17, 1986
    Date of Patent: July 19, 1988
    Assignee: Bayer AG
    Inventors: Walter Heitz, Reinhold Schwalm
  • Patent number: 4746737
    Abstract: Novel benzoyl esters of the following formula (I), and acid addition salts thereof, ##STR1## in which R.sub.1 and R.sub.2 are the same or different and represent a hydrogen atom or a lower alkoxy group, A represents a single bond, a linear or branched lower alkylene group, a lower alkenylene group, R.sub.3 and R.sub.4 are the same or different and represent a hydrogen atom or a lower alkyl group, or R.sub.3 and R.sub.4 join together to form a lower alkylene group, R.sub.5 represents a group of the formula, --X--(CO).sub.
    Type: Grant
    Filed: July 16, 1986
    Date of Patent: May 24, 1988
    Assignee: Kowa Co., Ltd.
    Inventors: Setsuro Fujii, Eizou Hattori, Mitsuteru Hirata, Koichiro Watanabe, Tomio Ohta, Nobuo Yokoo, Masahiko Nagakura
  • Patent number: 4719301
    Abstract: The invention is a process for the preparation of such 3-halo-2-hydroxyalkyl carbamates which comprises contacting an epihalohydrin carbonate with a secondary amine-containing compound, wherein the secondary amine has a pKa at which the secondary amine will react with the epihalohydrin carbonate and which does not catalyze the formation of unwanted by-products, in a polar organic solvent under conditions such that a 3-halo-2-hydroxyalkyl carbamate, wherein the carbamate nitrogen is tertiary, is prepared.
    Type: Grant
    Filed: September 4, 1986
    Date of Patent: January 12, 1988
    Assignee: The Dow Chemical Company
    Inventor: Joseph W. Hanafin
  • Patent number: 4673700
    Abstract: Amide substituted benzylhydroxylamine derivatives are effective in stabilizing polyolefin compositions containing a stabilizer or mixture of stabilizers selected from the group consisting of the phenolic antioxidants, the hindered amine light stabilizers, the alkylated hydroxybenzoate light stabilizers, the ultraviolet light absorbers, the organic phosphorus compounds, the alkaline metal salts of fatty acids and the thiosynergists, against degradation upon high temperature extrusion, exposure to the combustion products of natural gas, gamma irradation or upon storage for extended periods. These amide substituted benzylhydroxylamine derivatives exhibit resistance to loss or extraction during processing and in end-use applications.
    Type: Grant
    Filed: November 21, 1985
    Date of Patent: June 16, 1987
    Assignee: Ciba-Geigy Corporation
    Inventors: Ramanathan Ravichandran, Thomas E. Snead
  • Patent number: 4670434
    Abstract: This invention relates to compounds of the formula ##STR1## and the pharmaceutically acceptable acid addition salts thereof wherein the various substituents are defined herein. These compounds are cyclic AMP phosphodiesterase inhibitors useful as antithrombotic and inotropic agents in mammals.
    Type: Grant
    Filed: November 14, 1985
    Date of Patent: June 2, 1987
    Assignee: Syntex (U.S.A.) Inc.
    Inventor: Michael C. Venuti
  • Patent number: 4629791
    Abstract: The invention is a compound which comprises one or more 3-halo-2-hydroxyalkyl carbamate moieties; wherein the carbamate nitrogen is tertiary. In preferred embodiments, the carbamate nitrogen is tertiary, and the carbamate nitrogen is further substituted by an alicyclic or aliphatic moiety or is part of a heterocyclic ring, wherein the heterocyclic ring can contain an oxygen or sulfur atom or may contain another tertiary 3-halo-2-hydroxyalkyl carbamate moiety; or wherein two or more of such 3-halo-2-hydroxyalkyl carbamates are linked by an aliphatic or alicyclic moiety.
    Type: Grant
    Filed: August 9, 1984
    Date of Patent: December 16, 1986
    Assignee: The Dow Chemical Company
    Inventor: Joseph W. Hanafin
  • Patent number: 4565866
    Abstract: The instant invention relates to a process for the preparation of formamides in which ammonia, a primary or a secondary amine is reacted with carbon monoxide at an elevated temperature and pressure in the presence of a mixture consisting of a phenol and a phenate salt from the group consisting of an alkali metal phenate and an alkaline earth metal phenate, said phenol and said phenate salt each having the radical: ##STR1## wherein R is selected from the group consisting of an alkyl radical having from 3 to 18 carbon atoms and a hydroxyaryl radical of the formula: ##STR2## in which R' is an alkylene group having from 2 to 5 carbon atoms and in which x has a value of 1 to 2 when R is said alkyl radical and x has a value of 1 when R is said hydroxyaryl radical.
    Type: Grant
    Filed: January 24, 1984
    Date of Patent: January 21, 1986
    Assignee: Texaco Inc.
    Inventors: Roger G. Duranleau, John F. Knifton, George P. Speranza
  • Patent number: 4561451
    Abstract: This invention provides smoking compositions which contain a diacylpiperazine additive such as 1,4-(2-methylpropionyl)-2,3,5,6-tetramethylpiperazine: ##STR1## The preferred diacylpiperazine additives impart enhanced flavor response and smoothness.
    Type: Grant
    Filed: August 23, 1982
    Date of Patent: December 31, 1985
    Assignee: Philip Morris Incorporated
    Inventors: William B. Edwards, III, Yoram Houminer
  • Patent number: 4455309
    Abstract: New halo-methyl-thioamino-benzamides of the formula ##STR1## wherein X.sup.1 represents optionally substituted alkylene, arylene or alkarylene, it being possible for the alkylene and/or arylene and/or alkarylene groups to be linked via oxo, thio, carboxo, carboxamido or sulphoxo groups,A.sup.1 denotes the radical ##STR2## wherein Hal represents halogen,the various substituents R can be identical or different and represent hydrogen, optionally substituted alkyl or aryl or a substituted R, in the case where X.sup.1 denotes optionally substituted ethylene and m.sup.1 and n.sup.1 represent the number 1, forms an ethylene bridge by being linked to a second R,m.sup.1 denotes an integer from 1 to 5 and indicates the number of linkages of ##STR3## with X.sup.1, and n.sup.1 denotes a number from 1 to 100;a process for preparing the same by reaction of a halo-methyl-thioamino-benzoic acid fluoride with an amine in the presence of a base and the use of such halo-methyl-thioamino-benzamides as microbicidal agents.
    Type: Grant
    Filed: August 20, 1981
    Date of Patent: June 19, 1984
    Assignee: Bayer Aktiengesellschaft
    Inventors: Helmut Ritter, Wilfried Paulus, Engelbert Kuhle, Hermann Genth
  • Patent number: 4426380
    Abstract: The invention relates to novel furans, especially benzofuranones of the general formula ##STR1## in which R.sub.1 represents hydrogen or an aliphatic radical, R.sub.2 represents an amino group di-substituted by a divalent hydrocarbon radical, and the aromatic ring A may be additionally substituted, and their salts and/or isomers, processes for the manufacture of compounds of the formula (I) and their salts and isomers, pharmaceutical preparations containing these compounds, and their use as the active ingredients of medicaments as anti-inflammatory agents, analgesics or light-screening agents and/or for the manufacture of pharmaceutical preparations.
    Type: Grant
    Filed: October 21, 1982
    Date of Patent: January 17, 1984
    Assignee: Ciba-Geigy Corporation
    Inventors: Paul Wenk, Werner Breitenstein, Marcus Baumann
  • Patent number: 4421915
    Abstract: Compounds useful in making crosslinkable polymers having the formula (I): ##STR1## wherein R is hydrogen or methyl; R.sup.1 is cyano or ##STR2## wherein R.sup.2 is alkyl; Z is --X--R.sup.3 --X-- or ##STR3## wherein each --X-- is --O-- or --NR.sup.4 --, provided at least one --X-- is --NR.sup.4 -- wherein R.sup.4 is hydrogen or alkyl R.sup.3 is divalent hydrocarbon and D.sub.1 and D.sub.2 together are the carbon atoms necessary to complete a 5 to 7 membered ring. These compounds can be homopolymerized or copolymerized with each other or with other polymerizable ethylenically unsaturated monomers to give crosslinkable polymers. Such polymers can be purified by conventional purification techniques such as dialysis, diafiltration, ultrafiltration without losing their capability of crosslinking. The resulting purified polymers are particularly useful in photographic materials as gelatin extenders, binders or polymeric color couplers.
    Type: Grant
    Filed: April 19, 1982
    Date of Patent: December 20, 1983
    Assignee: Eastman Kodak Company
    Inventors: Ignazio S. Ponticello, Kenneth R. Hollister, Richard C. Tuites
  • Patent number: 4420482
    Abstract: The present invention concerns compounds of the general formula ##STR1## wherein X represents a direct linkage or a linear or branched oxyalkyl group containing one or more carbon atoms, as well as pharmaceutically acceptable salts of such compounds wherein X represents an oxyalkyl group, methods for their preparation by reaction of either piperazine or of its 1,4-bis-hydroxyalkyl derivatives with activated derivatives of acetylsalicylic acid such as halogenides, symmetric or mixed anhydrides, or with a haloalkylester of acetylsalicylic acid, and related pharmaceutical compositions having use as antipyretic, analgesic, anti-inflammatory and anti-histaminic agents.
    Type: Grant
    Filed: November 19, 1981
    Date of Patent: December 13, 1983
    Assignee: Selvi & C. S.p.A.
    Inventors: Carlo Milani, Giovanni M. Carminati, Attilio Sovera
  • Patent number: 4329462
    Abstract: Carboxylic amides can be produced simply and in good yield by reacting primary alcohols with at least one compound selected from ammonia, primary amines, and secondary amines, in the presence of a molecular oxygen-containing gas and a palladium or platinum catalyst under oxidative conditions.
    Type: Grant
    Filed: April 3, 1980
    Date of Patent: May 11, 1982
    Assignee: Asahi Kasei Kogyo Kabushiki Kaisha
    Inventors: Nobuhiro Tamura, Yohei Fukuoka, Joji Nishikido, Setsuo Yamamatsu, Yoshio Suzuki
  • Patent number: 4312869
    Abstract: Biphenylalkylene-thiazolyl-piperazines of the formula ##STR1## wherein Ar and A are as defined herein, e.g., 1-[4-(4-phenylsulfinylbenzyl)-2-thiazolyl]piperazine, and 1-[4-(4-biphenylylmethyl)-2-thiazolyl]piperazine, and their physiologically tolerable salts are provided. These compounds are useful as medicines for the treatment of inflammation with an immunological component, and are useful as hypolipemic and hypocholesterolemic agents and to assist lowering of lipid and cholesterol content in the blood.
    Type: Grant
    Filed: September 11, 1980
    Date of Patent: January 26, 1982
    Assignee: Science Union et Cie
    Inventors: Gilbert Regnier, Jacques Bure
  • Patent number: 4259476
    Abstract: Novel heterocyclic anthracycline compounds having antitumor activity against murine P388 leukemia in mice.
    Type: Grant
    Filed: April 2, 1979
    Date of Patent: March 31, 1981
    Inventors: Andrew S. Kende, Howard Newman
  • Patent number: 4243665
    Abstract: Compounds corresponding to the formula ##STR1## in which R' is a hydrogen atom or a methyl radical and R represents a radical ##STR2## in which Z is O, S, S.fwdarw.O, SO.sub.2 or NR.sub.1, in which R.sub.1 is a hydrogen atom or an alkyl, CONR.sub.2 R.sub.3, COOR.sub.2, COR.sub.2 or SO.sub.2 R.sub.2 radical, R.sub.2 and R.sub.3 each representing, independently of one another, a hydrogen atom, an alkyl radical having 1 to 4 carbon atoms, a phenyl radical or a CF.sub.3 radical, in the form of racemates or enantiomers if R' is CH.sub.3, and also, where appropriate, their addition salts with pharmaceutically acceptable acids.The compounds and salts are useful as anti-inflammatory agents, e.g. for treatment of arthritis. A process for preparing them and pharmaceutical compositions containing them are also claimed.
    Type: Grant
    Filed: November 21, 1978
    Date of Patent: January 6, 1981
    Assignee: Synthelabo
    Inventors: Thomas A. Purcell, Braham Shroot, Daniel J. M. Galtier
  • Patent number: 4189468
    Abstract: A cosmetic composition for the hair comprises at least one water-soluble crosslinked polymer obtained by crosslinking a polyamino-polyamide with a crosslinking agent, said polyamino-polyamide being prepared by the polycondensation of (a) an acidic compound selected from the group consisting of (i) organic dicarboxylic acid, (ii) ethylenically unsaturated aliphatic mono- or di-carboxylic acid, (iii) ester of said acids of (i) and (ii), and (iv) mixtures of (i), (ii) and (iii) on (b) a polyamine selected from the group consisting of bis-primary and mono- or bis-secondary polyalkylene polyamines, said polyamine (b) being replaceable by a member selected from the group consisting of (1) 0-20 mole percent hexamethylene diamine, (2) 0-40 mole percent bis-primary amine and (3) 0-40 mole percent bis-secondary amine, said crosslinking agent being selected from the group consisting of (a') simple bi-functional compounds selected from bis-halohydrins, bis-azetidinium, bis-haloacyl diamine and alkyl bis-halides, (b') oli
    Type: Grant
    Filed: February 27, 1978
    Date of Patent: February 19, 1980
    Assignee: L'Oreal
    Inventors: Guy Vanlerberghe, Henri Sebag, Jean-Francois Grollier, Alexandre Zysman
  • Patent number: 4134765
    Abstract: A vinylsulphone compound of the formula ##STR1## is provided. This compound is useful as cross-linking agent for hydrophilic colloids, especially for gelatin which is in the form of layers of photographic materials.
    Type: Grant
    Filed: January 11, 1978
    Date of Patent: January 16, 1979
    Assignee: Ciba-Geigy AG
    Inventor: Norman A. Smith
  • Patent number: 4101550
    Abstract: The compounds are esters and amides of trialkylhydroxyphenylalkanoic acid having the formula ##STR1## wherein R, R.sup.1 and R.sup.2 are independently lower alkyl or cycloalkyl groups, R.sup.3 is hydrogen, alkyl, cycloalkyl, alkylene, phenyl, phenyl substituted by alkyl groups, alkylthioethyl, thiobis-alkylene, alkyleneoxyalkylene, polyoxyalkylene or a polyvalent cyclic or acyclic hydrocarbon radical, R.sup.4 is hydrogen, lower alkyl, cycloalkyl, R.sup.5 is hydrogen, alkyl, phenyl, phenyl substituted with alkyl groups, alkylene, polyoxyalkylene or polyvalent cyclic or acyclic hydrocarbon radical, A is lower alkylene, m is 1 to 4 and n is 1 to 6.The ester compounds of this invention are prepared via usual esterification procedures from a suitable alcohol and an acid of the formula I ##STR2## or an acid halide or acid anhydride thereof.
    Type: Grant
    Filed: April 22, 1977
    Date of Patent: July 18, 1978
    Assignee: Ciba-Geigy Corporation
    Inventor: John D. Spivack
  • Patent number: 4093618
    Abstract: Ester and amides having the formula ##STR1## wherein R, R.sup.1 and R.sup.2 are independently lower alkyl or cycloalkyl groups, R.sup.3 is hydrogen, alkyl, cycloalkyl, alkylene, phenyl, phenyl substituted by alkyl groups, alkylthioethyl, thiobis-alkylene, alkyleneoxyalkylene, polyoxyalkylene or a polyvalent cyclic or acyclic hydrocarbon radical, R.sup.4 is hydrogen, lower alkyl, cycloalkyl, R.sup.5 is hydrogen, alkyl, phenyl, phenyl subsstituted by alkyl groups, alkylene, a polyvalent cyclic or acyclic hydrocarbon radical or alkyleneoxyalkylene, A is lower alkylene, m is 1 to 4 and n is 1 to 6.
    Type: Grant
    Filed: June 7, 1976
    Date of Patent: June 6, 1978
    Assignee: Ciba-Geigy Corporation
    Inventors: John D. Spivack, Martin Dexter
  • Patent number: 4088648
    Abstract: A vinylsulphone compound of the formula ##STR1## is provided. This compound is useful as cross-linking agent for hydrophilic colloids, especially for gelatin which is in the form of layers of photographic materials.
    Type: Grant
    Filed: October 22, 1976
    Date of Patent: May 9, 1978
    Assignee: Ciba-Geigy AG
    Inventor: Norman Alfred Smith