Abstract: The present invention are 2-(2-aryl-2-oxo-alkylidene) analogs of 1,2,3,4-tetrahydropyridine-3,5-pyridinecarboxylic acids and particularly esters thereof having valuable calcium antagonist and positive inotropic activity useful in the treatment of cardiovascular disorders, pharmaceutical compositions and methods of use therefor.

Abstract: The adducts of isocyanates wtih benzoxazolones or benzoxazinediones are novel compounds which may be employed as blocked isocyanates and are particularly useful as latent, epoxide curing agents. At typical epoxide curing temperatures, the isocyanate is oxirane or hydroxyl reactive and the benzoxazole or benzoxazinedione acts like a di- or trifunctional phenol, respectively.

Abstract: Compounds of the formula: ##STR1## wherein R.sup.2 is --(CH.sub.2).sub.k --X--(CH.sub.2).sub.j --NHR.sup.3 ; wherein k is 0 to 3, j is 1 or 2; X is F or OH; and, R.sup.3 is hydrogen; loweralkyl or loweraralkyl which may be substituted by hydroxy, carboxy, carbamoyl, or carbalkoxy; or, acyl; and, a pharmaceutically acceptable salt thereof; are inhibitors of angiotensin I converting enzyme useful as antihypertensive agents.

Abstract: 3,3'-Bis-Methylene-1,3-benzothiazine compounds are inhibitors of phenylethanolamine N-methyl-transferase.

Abstract: Heterocyclic compounds of the general formula: ##STR1## wherein: R.sub.1 represents alkyl, haloalkyl, alkenyl, haloalkenyl, arylalkyl, arylhaloalkyl, cycloalkyl, halocycloalkyl, aryl, haloaryl, alkoxyalkyl or haloalkoxyalkyl;X.sub.1 is chlorine, bromine, or fluorine;X.sub.2 and X.sub.3 are hydrogen, chlorine, bromine or fluorine;A represents oxygen or sulphur, S-O ##STR2## or N-R.sub.8 ; R.sub.8 is hydrogen, alkyl, haloalkyl, hydroxyalkyl, alkoxyalkyl, arylalkyl, aryl or ##STR3## B represents ##STR4## m is 0, 1 or 2; n and p are 0 or 1;R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R'.sub.2, R'.sub.3, R'.sub.4, R'.sub.5 are the same or different and are hydrogen, alkyl, alkoxyalkyl, haloalkyl, or hydroxyalkyl;and Y and Z are the same or different and are hydrogen, halogen, alkyl or alkoxy.These compounds are used as antidotes against herbicides.

Abstract: A thiazine derivative, which forms a color on contact with an electron accepting material, represented by the formula (II): ##STR1## wherein A.sub.1 and A.sub.2, which may be the same or different, each represents an aryl group or a heterocyclic group and A.sub.1 and A.sub.2 may combine together to form a heterocyclic ring or a fluorene ring, the ring B represents an aromatic hydrocarbon ring or a heterocyclic ring, and Y represents a hydrogen atom, an aliphatic group, an aryl group, a heterocyclic group, an amino group, an amido group, an oxy group or a thio group, but at least one of A.sub.1 and A.sub.2 or the ring formed by the combination of A.sub.1 and A.sub.2 represents an electron donating aryl group or an electron donating heterocyclic group, and a process for preparing the thiazine derivatives represented by the formula (II) by oxidizing a thioamide derivative represented by the formula (I): ##STR2## wherein A.sub.1, A.sub.2, B and Y are as above described.

Abstract: 4-OXO-2-(3-HYDROXY-4-METHOXYPHENYL)-2, 3-DIHYDRO-5, 6-BENZO-1, 3-THIAZINE AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF ARE PROVIDED. The thiazine is produced by a process which comprises reducing a dithiosalicyclic acid amide of the formula ##STR1## to form the thiosalicyclic acid amide of the formula ##STR2## and reacting the resulting compound with isovanillin.

Abstract: Compounds of the formfulas ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, m and n and X are as hereinafter set forth,Are described. The compounds of formulas I and Ia are useful as neuroleptic agents.