Silicon Containing Patents (Class 546/14)
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Patent number: 8969561Abstract: Process for the preparation of apixaban and intermediates useful for the preparation thereof.Type: GrantFiled: October 10, 2014Date of Patent: March 3, 2015Assignee: Dipharma Francis S.r.l.Inventors: Emanuele Attolino, Alessandro Lombardo, Simone Tambini
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Publication number: 20150057247Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of degenerative diseases and disorders.Type: ApplicationFiled: October 29, 2014Publication date: February 26, 2015Inventors: Craig C. Beeson, Christopher C. Lindsey, Yuri K. Peterson, Baerbel Rohrer
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Publication number: 20150048323Abstract: A condensed-cyclic compound and an organic light-emitting device including the same, the compound being represented by Formula 1, below:Type: ApplicationFiled: April 22, 2014Publication date: February 19, 2015Applicant: SAMSUNG DISPLAY CO., LTD.Inventors: Soo-Yon KIM, Seok-Hwan HWANG, Young-Kook KIM, Hye-Jin JUNG, Jun-Ha PARK, Eun-Young LEE, Jong-Woo KIM, Jin-O LIM, Sang-Hyun HAN, Kwang-Hyun KIM, Eun-Jae JEONG
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Patent number: 8957215Abstract: The present invention relates to novel heteroaryl substituted benzothiazole derivatives, precursors thereof, and therapeutic uses for such compounds, having the structural formula (I) below: and to their pharmaceutically acceptable salt, compositions and methods of use. Furthermore, the invention relates to novel heteroaryl substituted benzothiazole derivatives that are suitable for imaging amyloid deposits in living patients, their compositions, methods of use and processes to make such compounds. More specifically, the present invention relates to a method of imaging amyloid deposits in brain in vivo to allow antemortem diagnosis of Alzheimer's disease as well as measuring clinical efficacy of Alzheimer's disease therapeutic agents.Type: GrantFiled: April 23, 2012Date of Patent: February 17, 2015Assignee: Navidea Biopharmaceuticals, Inc.Inventors: Ylva Gravenfors, Catrin Jonasson, Jonas Malmstrom, Gunnar Nordvall, David Pyring, Can Slivo, Daniel Sohn, Peter Strom, David Wensbo
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Publication number: 20150034161Abstract: Organic molecule semi-conducting chromophores containing a halogen-substituted core structure are disclosed. Such compounds can be used in organic heterojunction devices, such as organic molecule solar cells and transistors.Type: ApplicationFiled: February 19, 2013Publication date: February 5, 2015Inventors: Arnold B. Tamayo, Corey V. Hoven, Thomas K. Wood, Braden Smith
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Publication number: 20150038707Abstract: Methods for preventing pest infestations are disclosed. In some embodiments, the methods for preventing infestations involve use of pyrethroid insecticides or the stereoisomers or salts thereof.Type: ApplicationFiled: September 19, 2013Publication date: February 5, 2015Inventors: Kevin M. Belyk, Edward Cleator, Shen-Chun Kuo, Peter Emmanuel Maligres, Bangping Xiang, Nobuyoshi Yasuda, Jianguo Yin
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Publication number: 20150038714Abstract: The present invention relates to novel and concise process for the construction of chiral 3-substituted tetrahyroquinoline derivatives based on proline catalyzed asymmetric ?-functionalization of aldehyde, followed by in situ reductive cyclization of nitro group under catalytic hydrogenation condition with high optical purities. Further the invention relates to conversion of derived chiral 3-substituted tetrahydroquinoline derivatives into therapeutic agents namely (?)-sumanirole (96% ee) and 1-[(S)-3-(di-methylamino)-3,4-dihydro-6,7-dimethoxy-quinolin-1(2H)-yl]propanone[(S)-903] (92% ee).Type: ApplicationFiled: March 19, 2013Publication date: February 5, 2015Applicant: Council of Scientific & Industrial ResearchInventors: Varun Rawat, Senthil Kumar Boopathi, Arumugam Sudalai
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Publication number: 20150024608Abstract: Described herein are precursors and methods for forming silicon-containing films. In one aspect, there is provided a precursor of Formula I: wherein R1 is selected from linear or branched C3 to C10 alkyl group, linear or branched C3 to C10 alkenyl group, linear or branched C3 to C10 alkynyl group, C1 to C6 dialkylamino group, electron withdrawing group, and C6 to C10 aryl group; R2 is selected from hydrogen, linear or branched C1 to C10 alkyl group, linear or branched C3 to C6 alkenyl group, linear or branched C3 to C6 alkynyl group, C1 to C6 dialkylamino group, C6 to C10 aryl group, linear or branched C1 to C6 fluorinated alkyl group, electron withdrawing group, and C4 to C10 aryl group; optionally wherein R1 and R2 are linked together to form ring selected from substituted or unsubstituted aromatic ring or substituted or unsubstituted aliphatic ring; and n=1 or 2.Type: ApplicationFiled: October 10, 2014Publication date: January 22, 2015Applicant: AIR PRODUCTS AND CHEMICALS, INC.Inventors: Steven Gerard Mayorga, Heather Regina Bowen, Xinjian Lei, Manchao Xiao, Haripin Chandra, Anupama Mallikarjunan, Ronald Martin Pearlstein
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Publication number: 20150025242Abstract: Process for the preparation of apixaban and intermediates useful for the preparation thereof.Type: ApplicationFiled: October 10, 2014Publication date: January 22, 2015Applicant: DIPHARMA FRANCIS S.r.l.Inventors: Emanuele ATTOLINO, Alessandro LOMBARDO, Simone TAMBINI
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Patent number: 8937122Abstract: A compound has excellent thermal resistance and compatibility with resins, improves thermal resistance of resins, and specifically provides a compound represented by the following general formula (1). In formula (1), R1 to R4 each represent a C1-12 alkyl group or a C6-12 aryl group, y represents a number 1-2,000, and X1 represents a group represented by the formula (2) or (3). In formula (2), R5 represents a hydrogen atom, O., a C1-12 alkyl group or a C1-12 alkoxy group, L1 represents a C1-6 alkylene group or a C6-12 arylene group. In formula (3), R6 represents a C1-4 alkyl group or a C6-12 aryl group, X2 represents a group represented by the formula (2) or a hydrogen atom, s represents a number 2-6, L2 represents a C1-6 alkylene group or a C6-12 arylene group, and at least one of s number of X2s is the group represented by the formula (2).Type: GrantFiled: November 15, 2011Date of Patent: January 20, 2015Assignee: Adeka CoporationInventors: Ken-ichiro Hiwatari, Tomoaki Saiki
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Patent number: 8921576Abstract: The present invention provides a novel compound represented by a general formula (1) as shown below, which has a glucokinase-activating action in the liver and pancreatic ?-cells and which is useful as an agent for preventing and/or treating diseases caused by hyperglycemia, such as diabetes. A spiroindoline compound represented by the general formula (1), or a salt thereof, or a solvate of the compound or the salt: [wherein ring A represents a nitrogen-containing 5-10 membered heteroaryl group; R1 and R2, which are the same or different, each represent a hydrogen atom, a halogen atom, a halo C1-6 alkyl group, a C6-10 aryl group, a cyano group, a C1-6 alkyl group optionally having a substituent, a C2-6 alkenyl group optionally having a substituent, etc.; R3 represents a hydrogen atom, a C1-6 alkyl group optionally having a substituent, etc.; and R4 represents a hydrogen atom, a halogen atom, a C1-6 alkyl group optionally having a substituent, etc.Type: GrantFiled: October 18, 2012Date of Patent: December 30, 2014Assignee: Kowa Company, Ltd.Inventors: Takahisa Ogamino, Yukiyoshi Yamazaki, Shin Tanikawa, Ayumu Okuda, Tomoaki Fukuda, Okihisa Tokuda, Yoshiharu Miyake, Shinsuke Itoh, Hiroyuki Ishiwata
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Publication number: 20140378416Abstract: The present invention relates to novel Silyl-Containing Heterocyclic Compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein A, B, C, D, E, F and L are as defined herein. The present invention also relates to compositions comprising at least one Silyl-Containing Heterocyclic Compound, and methods of using the Silyl-Containing Heterocyclic Compounds for treating or preventing HCV infection in a patient.Type: ApplicationFiled: September 11, 2012Publication date: December 25, 2014Inventors: Michael P. Dwyer, Kartik M. Keertikar, Qingbei Zeng, Robert D. Mazzola, JR., Wensheng Yu, Haiqun Tang, Seong Heon Kim, Ling Tong, Stuart B. Rosenblum, Joseph A. Kozlowski, Anilkumar Gopinadhan Nair
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Publication number: 20140364393Abstract: The present invention is directed to novel piperidinyl-carboxamide derivatives, pharmaceutical compositions containing them and their use as inhibitors of SCD1, useful in the treatment of obesity, type-II diabetes and other related metabolic disorders.Type: ApplicationFiled: December 5, 2012Publication date: December 11, 2014Inventors: Shyh-Ming Yang, Gee-Hong Kuo, Micheal D. Gaul, Thomas A. Rano
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Publication number: 20140349848Abstract: The present invention provides fungicidal 4-substituted-3-{phenyl[(heterocyclylmethoxy)imino]methyl}-1,2,4-oxadiazol-5(4H)-one derivatives of formula (I) wherein A represents a pyridyl or thiazole group and X1, Y1 to Y5 represent independently different substituents.Type: ApplicationFiled: September 10, 2012Publication date: November 27, 2014Inventors: Christoph Braun, Haruko Sawada, Helene Lachaise, Stephane Brunet, Philippe Rinolfi, Christophe Dubost, Pierre-Yves Coqueron, Simon Maechling, Anne-Sophie Rebstock, Ulrike Wachendorff-Neumann
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Publication number: 20140343015Abstract: A morphinan derivative represented by the following general formula (I) (in the formula, R1 represents hydrogen, C1-6 alkyl, cycloalkylalkyl (the cycloalkyl moiety has 3 to 6 carbon atoms, and the alkylene moiety has 1 to 5 carbon atoms), aralkyl (the aryl moiety has 6 to 10 carbon atoms, and the alkylene moiety has 1 to 5 carbon atoms) and the like, R2 represents hydrogen, C1-6 alkyl, C3-6 cycloalkyl, C6-10 aryl, aralkyl (the aryl moiety has 6 to 10 carbon atoms, and the alkylene moiety has 1 to 5 carbon atoms) and the like, R3, R4 and R5 represent hydrogen, hydroxy, carbamoyl, C1-6 alkoxy, C6-10 aryloxy and the like, R6a, R6b, R7, R8, R9, and R10 represent hydrogen and the like, X represents O or CH2, and Y represents C?O, SO2, an atomic bond and the like), or an acid addition salt thereof is used as an analgesic.Type: ApplicationFiled: September 7, 2012Publication date: November 20, 2014Applicants: NIPPON CHEMIPHAR CO., LTD., THE KITASATO INSTITUTEInventors: Hiroshi Nagase, Hideaki Fujii, Eriko Nakata, Yoshikazu Watanabe, Toshihiro Takahashi
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Publication number: 20140332772Abstract: A styryl-based compound represented by Formula 1 below is disclosed. An organic light-emitting diode including the styryl-based compound is also disclosed.Type: ApplicationFiled: November 8, 2013Publication date: November 13, 2014Applicant: SAMSUNG DISPLAY CO., LTD.Inventors: Sang-Hyun Han, Seok-Hwan Hwang, Young-Kook Kim, Hye-Jin Jung, Jin-O Lim, Soo-Yon Kim, Eun-Jae Jeong, Jun-Ha Park, Eun-Young Lee, Jong-Hyuk Lee
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Publication number: 20140335201Abstract: The present invention provides a composition comprising a combination of components A) and B), wherein component A) is a compound of formula (I) and the component (B) is a further fungicide, insecticide or herbicide.Type: ApplicationFiled: April 9, 2012Publication date: November 13, 2014Applicant: SYNGENTA PARTICIPATIONS AGInventors: Ulrich Johannes Haas, Dietrich Hermann, Gabriel Didier Scalliet, Kurt Nebel, Long Lu, Jianzhong Yang, Qiang Lu, Thomas James Hoffman, Renaud Beaudegnies, Werner Zambach, Olivier Jacob
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Patent number: 8883763Abstract: The use of isoquinolones for preparing drugs, including novel isoquinolones as well as their synthesis method. In particular, isoquinolone derivatives used in the treatment of pathological angiogenesis, and more particularly of cancer.Type: GrantFiled: March 1, 2011Date of Patent: November 11, 2014Assignees: Universite Joseph Fourier, Centre National de la Recherche Scientifique, Institut CurieInventors: Andrei Popov, Aurélie Juhem, Jean-Claude Florent, Chi-Hung N'Guyen
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Patent number: 8884016Abstract: Process for the preparation of apixaban and intermediates useful for the preparation thereof.Type: GrantFiled: June 7, 2012Date of Patent: November 11, 2014Assignee: Dipharma Francis S.r.l.Inventor: Chiara Vladiskovic
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Patent number: 8877954Abstract: The present invention discloses functionalized nanoparticles comprising on the surface a covalently bound radical of the formula (I) wherein the nanoparticles are SiO2, Al2O3 or mixed SiO2 and Al2O3 nanoparticles, and wherein the general symbols are as defined in claim 1. These functionalized nanoparticles are for example useful as stabilizers and/or compatibilizers in organic materials, or as photoinitiators in pre-polymeric or pre-crosslinking formulations, or as reinforcer of coatings and improver of scratch resistance in coating compositions for surfaces.Type: GrantFiled: June 28, 2013Date of Patent: November 4, 2014Assignee: BASF SEInventors: Thomas Giesenberg, Andreas Muhlebach, Tunja Jung, Francois Rime, Laurent Michau, Martin Muller, Didier Bauer
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Publication number: 20140319473Abstract: A compound represented by Formula 1 below and an organic light-emitting device including the compound are provided: Substituents in Formula 1 are the same as defined in the specification.Type: ApplicationFiled: September 13, 2013Publication date: October 30, 2014Applicant: Samsung Display Co., Ltd.Inventor: Jung-Sub Lee
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Publication number: 20140315857Abstract: Disclosed are compounds of Formula 1, N-oxides, and salts thereof, wherein Q, A, R1, R2, R3 and n are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula 1 and methods for treating helminth infections comprising administration to an animal a parasiticidally effective amount of a compound or a composition of the invention.Type: ApplicationFiled: November 7, 2012Publication date: October 23, 2014Inventors: George Philip Lahm, Moumita Kar
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Publication number: 20140314677Abstract: The invention provides a family of fluorescent compounds. The compounds are substituted silaxanthenium compounds that can be chemically linked to one or more biomolecules, such as a protein, nucleic acid, and therapeutic small molecule. The compounds can be used for imaging in a variety of medical, biological and diagnostic applications. The dyes are particularly useful for in vitro, in vivo and ex vivo imaging applications.Type: ApplicationFiled: March 17, 2014Publication date: October 23, 2014Applicant: VisEn Medical, Inc.Inventors: Kevin Groves, Ryan Buff
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Publication number: 20140315858Abstract: The present invention relates to fungicidal N-[(trisubstitutedsilyl)methyl]carboxamide or its thiocarboxamide derivative, their process of preparation and intermediate compounds for their preparation, their use as fungicides, particularly in the form of fungicidal compositions and methods for the control of phytopathogenic fungi of plants using these compounds or their compositions.Type: ApplicationFiled: November 20, 2012Publication date: October 23, 2014Inventors: Juergen Benting, Pierre Cristau, Philippe Desbordes, Hélène Lachaise, Philippe Rinolfi
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Patent number: 8859772Abstract: The present invention is directed to novel process for the preparation of regioselective perylenediimides derivatives, specifically mono and dibrominated derivatives.Type: GrantFiled: February 20, 2013Date of Patent: October 14, 2014Assignee: Yeda Research and Development Co. Ltd.Inventors: Boris Rybtchinski, Paramasivan Rajasingh, Elijah Shirman
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Publication number: 20140291652Abstract: An organic electroluminescent element using a compound represented by the following general formula (I) emits dark blue light and has small changes in the chromaticity and in the driving voltage even after driving for a long period of time: wherein R1 to R6; Q1 and Q2; X1, X2, X3 and X4 are as defined herein.Type: ApplicationFiled: August 6, 2012Publication date: October 2, 2014Applicant: UDC IRELAND LIMITEDInventors: Saki Takada, Koji Takaku, Tetsu Kitamura, Toshihiro Ise, Wataru Sotoyama
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Publication number: 20140287164Abstract: Described herein are compositions for depositing a carbon-doped silicon containing film wherein the composition comprises a first precursor comprising at least one compound selected from the group consisting of: an organoaminoalkylsilane having a formula of R5Si(NR3R4)xH3-x wherein x=1, 2, 3; an organoalkoxyalkylsilane having a formula of R6Si(OR7)xH3-x wherein x=1, 2, 3; an organoaminosilane having a formula of R8N(SiR9(NR10R11)H)2; an organoaminosilane having a formula of R8N(SiR9LH)2 and combinations thereof; and optionally a second precursor comprising a compound having the formula: Si(NR1R2)H3. Also described herein are methods for depositing a carbon-doped silicon-containing film using the composition wherein the method is one selected from the following: cyclic chemical vapor deposition (CCVD), atomic layer deposition (ALD), plasma enhanced ALD (PEALD) and plasma enhanced CCVD (PECCVD).Type: ApplicationFiled: June 1, 2012Publication date: September 25, 2014Applicant: AIR PRODUCTS AND CHEMICALS, INC.Inventors: Manchao Xiao, Xinjian Lei, Ronald Martin Pearlstein, Haripin Chandra, Eugene Joseph Karwacki, JR., Bing Han, Mark Leonard O'Neill
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Publication number: 20140288308Abstract: According to the present invention there are provided novel processes for the manufacture of the compound of formula 1 as well as intermediates and novel synthesis routes for key intermediates used in those processes.Type: ApplicationFiled: June 4, 2014Publication date: September 25, 2014Inventors: Corey James BRUMSTED, Hendrik MOORLAG, Roumen Nikolaev RADINOV, Yi REN, Pius WALDMEIER
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Publication number: 20140274950Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of degenerative diseases and disorders.Type: ApplicationFiled: March 13, 2013Publication date: September 18, 2014Applicant: Medical University of South CarolinaInventors: Craig C. BEESON, Christopher C. LINDSEY, Yuri K. PETERSON, Baerbel ROHRER
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Publication number: 20140261647Abstract: A novel compound represented by general formula (1), a support supporting this novel compound, and a photoelectric transduction element using this support. (In the formula, Y is an optionally substituted hydrocarbon group having 1-20 carbon atoms having —CO—NR4- or —SO2—NR4- in the group; Z is a group of a conjugated system; R1, R2, and R3 represent optionally substituted hydrocarbon groups or optionally substituted hydrocarbon-oxy groups; at least one of R1, R2, and R3 is an optionally substituted hydrocarbon-oxy group; R4 represents a hydrogen atom or an optionally substituted hydrocarbon group having 1-20 carbon atoms; R4 and Z may join together to form a ring. However, Y excludes groups represented by partial structural formulas (Y-11) and (Y-12).Type: ApplicationFiled: August 21, 2012Publication date: September 18, 2014Applicant: ADEKA CORPORATIONInventors: Yohei Aoyama, Kazuyuki Noda, Hiroyuki Osada
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Publication number: 20140275072Abstract: The invention relates to compounds of the formula (I) in which R1, L and m have the meaning indicated in the claims, and/or physiologically acceptable salts, tautomers and stereoisomers thereof, including mixtures thereof in all ratios. The compounds of the formula (I) can be used for the inhibition of serine/threonine protein kinases and for the sensitisation of cancer cells to anticancer agents and/or ionising radiation. The invention also relates to the use of the compounds of the formula (I) in the prophylaxis, therapy or progress control of cancer, tumours, metastases or angiogenesis disorders, in combination with radiotherapy and/or an anticancer agent. The invention furthermore relates to a process for the preparation of the compounds of the formula (I) by reaction of compounds of the formulae (II) and (III) and optionally conversion of a base or acid of the compounds of the formula (I) into a salt thereof.Type: ApplicationFiled: October 30, 2012Publication date: September 18, 2014Applicant: Merck Patent GmbHInventors: Werner Mederski, Thomas Fuchss, Ulrich Emde, Hans-Peter Buchstaller
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Patent number: 8835409Abstract: 3-Alkenyl-6-halo-4-aminopicolinic acids and their derivatives are potent herbicides demonstrating a broad spectrum of weed control.Type: GrantFiled: January 24, 2012Date of Patent: September 16, 2014Assignee: Dow AgroSciences, LLC.Inventors: Joseph D. Eckelbarger, Jeffrey B. Epp, Paul R. Schmitzer, Thomas L. Siddall
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Publication number: 20140256677Abstract: Heterocyclylpyri(mi)dinylpyrazole of the formula (I) in which R1 to R5, X1, U, Q, W, Y, n, a, b have the meanings given in the description, and agrochemically active salts, to their use and to methods and compositions for controlling phytopathogenic harmful fungi in and/or on plants or in and/or on seed of plants and for reducing mycotoxins in plants and parts of the plants, to processes for preparing such compounds and compositions and treated seed and also to their use for controlling phytopathogenic harmful fungi in agriculture, horticulture, forestry, in animal husbandry, in the protection of materials, in the domestic and hygiene field and for the reduction of mycotoxins in plants and parts of the plantsType: ApplicationFiled: October 4, 2012Publication date: September 11, 2014Inventors: Stefan Hillebrand, Amos Mattes, Alexander Sudau, Pierre Wasnaire, Jürgen Benting, Peter Dahmen, Ulrike Wachendorff-Neumann, Haruko Sawada, Philippe Desbordes, Anne-Sophie Rebstock, Stéphane Brunet, Hélène Lachaise, Philippe Rinolfi
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Publication number: 20140252318Abstract: A compound according to a formula I and devices incorporating the same are described. The compound according to the formula I can have the structure: wherein X is Si or Ge; R1 and R2 represent mono, di, tri, tetra, or penta substitutions or no substitution; R3, R4 represent mono, di, tri, or tetra substitutions or no substitution; R1 and R2 are optionally joined to form a ring, which may be further substituted; L is a single bond or comprises an aryl or heteroaryl group having from 5-20 carbon atoms, which is optionally further substituted; and A is an aromatic group. A contains a group selected from the group consisting of indole, carbazole, benzofuran, dibenzofuran, benzothiophene, dibenzothiophene, benzoselenophene, dibenzoselenophene, triphenylene, azacarbazole, azadibenzofuran, azadibenzothiophene, azadibenzoselenophene, azatriphenylene, and combinations thereof, which are optionally further substituted. The device can include the compound according to Formula I in an organic layer.Type: ApplicationFiled: March 7, 2013Publication date: September 11, 2014Applicant: Universal Display CorporationInventors: Pierre-Luc T. Boudreault, Chuanjun Xia
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Patent number: 8829187Abstract: Diastereomeric pyrrolidine compounds and methods of preparation, as can be used en route to the preparation of a range of nitric oxide synthase inhibitors.Type: GrantFiled: March 4, 2013Date of Patent: September 9, 2014Assignee: Northwestern UniversityInventors: Richard B. Silverman, Fengtian Xue
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Publication number: 20140249308Abstract: The present invention relates to electronic devices, in particular organic electroluminescent devices, comprising compounds of the formula (1), to the corresponding compounds, and to a process for the preparation of these compounds.Type: ApplicationFiled: October 11, 2012Publication date: September 4, 2014Applicant: Merck Patent GmbHInventors: Amir Hossain Parham, Christof Pflumm, Anja Jatsch, Thomas Eberle, Philipp Stoessel
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Patent number: 8822691Abstract: To provide novel carboxamides which exhibit an excellent pesticidal activity as pesticides. Carboxamides represented by the following Formula (I) and use thereof as pesticides and an animal parasite control agent: wherein each substituent is as defined in the specification.Type: GrantFiled: July 10, 2010Date of Patent: September 2, 2014Assignee: Bayer CropScience AGInventors: Jun Mihara, Koichi Araki, Takuma Mori, Tetsuya Murata, Yasushi Yoneta, Eiichi Shimojo, Teruyuki Ichihara, Masashi Ataka, Katsuhiko Shibuya, Ulrich Görgens
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Patent number: 8822679Abstract: A compound useful as a building block for the manufacture of various compounds is represented by Formula A or D. In Formula A and D, z is 0 or 1; Q is a heteroatom; R1 through R11 and Ra through Rf are each independently hydrogen, a substituted or unsubstituted hydrocarbyl group, a substituted or unsubstituted heteroatom containing hydrocarbyl group, or a functional group; d, e and f are each independently 0 or greater; each of A, B and D is independently a carbon atom or a heteroatom; and two or more of R1 though R11, Ra through Rf and Y optionally combine to form a ring. In some embodiments, R8 and R9 combine to form a carbonyl group. In some embodiments, R2 and Y combine to form a ring with the Q atom. In some embodiments, the ring includes at least one double bond.Type: GrantFiled: June 22, 2012Date of Patent: September 2, 2014Assignee: California Institute of TechnologyInventors: Brian M Stoltz, Scott C. Virgil, David E White, Taiga Yurino, Yiyang Liu, Douglas C Behenna, Douglas Duquette, Christian Eidamshaus
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Publication number: 20140243286Abstract: Described herein are monomers capable of forming a biologically useful multimer when in contact with one, two, three or more other monomers in an aqueous media. In one aspect, such monomers may be capable of binding to another monomer in an aqueous media (e.g. in vivo) to form a multimer (e.g. a dimer). Contemplated monomers may include a ligand moiety, a linker element, and a connector element that joins the ligand moiety and the linker element. In an aqueous media, such contemplated monomers may join together via each linker element and may thus be capable of modulating one or more biomolecules substantially simultaneously, e.g., modulate two or more binding domains on a protein or on different proteins.Type: ApplicationFiled: February 28, 2014Publication date: August 28, 2014Applicant: Coferon, Inc.Inventors: Lee Daniel Arnold, Kenneth W. Foreman, Douglas S. Werner
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Publication number: 20140228320Abstract: The present invention provides a compound which has the effect of PDE inhibition, and which is useful as an agent for preventing or treating schizophrenia or so on represented by the formula (I):Type: ApplicationFiled: April 15, 2014Publication date: August 14, 2014Applicant: Takeda Pharmaceutical Company LimitedInventors: Takahiko TANIGUCHI, Masato YOSHIKAWA, Kasei MIURA, Tomoaki HASUI, Eiji HONDA, Keisuke IMAMURA, Makoto KAMATA, Haruhi KAMISAKI, John F. QUINN, Joseph RAKER, Fatoumata CAMARA, Yi WANG
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Publication number: 20140221203Abstract: Disclosed are compounds of Formula 1, N-oxides, and salts thereof, wherein Z is O or S; and R1, R2, R3, Q and n are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling a parasitic nematode comprising contacting the parasitic nematode or its environment with a biologically effective amount of a compound or a composition of the invention.Type: ApplicationFiled: April 10, 2014Publication date: August 7, 2014Applicant: E I DU PONT DE NEMOURS AND COMPANYInventors: George Philip LAHM, Renee Marie LETT, Brenton Todd SMITH, Benjamin Kenneth SMITH, Clarice Anne TYLER
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Publication number: 20140209869Abstract: A silicon-based compound represented by Formula 1 below and an organic light-emitting device including the silicon-based compound are provided.Type: ApplicationFiled: May 29, 2013Publication date: July 31, 2014Inventors: Hye-Jin Jung, Seok-Hwan Hwang, Young-Kook Kim, Jun-Ha Park, Eun-Young Lee, Jin-O Lim, Sang-Hyun Han, Eun-Jae Jeong, Soo-Yon Kim, Jong-Hyuk Lee
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Publication number: 20140203270Abstract: Provided are a material for an organic electroluminescent element formed of a silicon-containing four-membered ring compound, and an organic electroluminescent element using the material. The material for an organic electroluminescent element is formed of a compound represented by the following formula (1) and is used for, for example, a light-emitting layer containing a phosphorescent light-emitting dopant in an organic electroluminescent element. In the formula, X represents nitrogen or phosphorus, L's each represent an (n+1)-valent aromatic hydrocarbon group or aromatic heterocyclic group, and at least one of the L's represents an aromatic heterocyclic group. A1 to A6 each represent an alkyl group, a cycloalkyl group, an alkenyl group, an alkynyl group, an aromatic hydrocarbon group, an aromatic heterocyclic group, or an amino group, and n represents an integer of 0 to 3.Type: ApplicationFiled: August 31, 2012Publication date: July 24, 2014Applicant: NIPPON STEEL & SUMIKIN CHEMICAL CO., LTD.Inventor: Mitsuru Suda
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Publication number: 20140206646Abstract: Heteroarylpiperidine and -piperazine derivatives of the formula (I) in which the symbols A, X, Y, L1, L2, G, Q, p, R1, R2 and R10 are each as defined in the description, and salts, metal complexes and N-oxides of the compounds of the formula (I), and the use thereof for controlling phytopathogenic harmful fungi and processes for preparing compounds of the formula (I).Type: ApplicationFiled: March 26, 2014Publication date: July 24, 2014Applicant: BAYER CROPSCIENCE AGInventors: Tomoki TSUCHIYA, Pierre WASNAIRE, Sebastian HOFFMANN, Pierre CRISTAU, Thomas SEITZ, Joachim KLUTH, Stefan HILLEBRAND, Juergen BENTING, Daniela PORTZ, Ulrike WACHENDORFF-NEUMANN
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Patent number: 8771807Abstract: Described herein are organoaminosilane precursors which can be used to deposit silicon containing films which contain silicon and methods for making these precursors. Also disclosed herein are deposition methods for making silicon-containing films or silicon containing films using the organoaminosilane precursors described herein. Also disclosed herein are the vessels that comprise the organoaminosilane precursors or a composition thereof that can be used, for example, to deliver the precursor to a reactor in order to deposit a silicon-containing film.Type: GrantFiled: May 17, 2012Date of Patent: July 8, 2014Assignee: Air Products and Chemicals, Inc.Inventors: Manchao Xiao, Xinjian Lei, Bing Han, Mark Leonard O'Neill, Ronald Martin Pearlstein, Richard Ho, Haripin Chandra, Agnes Derecskei-Kovacs
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Publication number: 20140186872Abstract: The present invention provides compounds having the formula A: (A) or pharmaceutically acceptable salt thereof, wherein W, R1, R2 and R5 are as defined in classes and subclasses herein, and pharmaceutical compositions thereof, as described generally and in subclasses herein, which compounds are useful as cytotoxic agents towards proliferating and/or quiescent cancer stem cells, and thus are useful, for example, for the treatment of cancer.Type: ApplicationFiled: June 6, 2012Publication date: July 3, 2014Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE- CNRS, UNIVERSITE DE STRASBOURGInventors: Marie Feve, Maria Zeniou-Meyer, Jacques Haiech, Herve Chneiweiss, Marie-Claude Kilhoffer, Samir Mameri, Marcel Hibert
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Patent number: 8765782Abstract: The present invention is directed to novel indole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the androgen receptor.Type: GrantFiled: February 17, 2010Date of Patent: July 1, 2014Assignee: Janssen Pharmaceutica, NVInventors: James C. Lanter, Zhihua Sui, James J. Fiordeliso, Weiqin Jiang, Xuqing Zhang
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Patent number: 8759529Abstract: A process for producing compound C represented by formula C is disclosed: wherein R? represents substituent groups as described herein. The process can produce pyripyropene derivatives that have acyloxy groups at the 1- and 11-positions and a hydroxyl group at the 7-position and are useful as insect pest control agents at a high yield.Type: GrantFiled: August 13, 2012Date of Patent: June 24, 2014Assignee: BASF SEInventors: Kimihiko Goto, Kazumi Yamamoto, Masayo Sakai, Masaaki Mitomi, Takashi Ando
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Publication number: 20140167002Abstract: Small organic molecule semi-conducting chromophores containing a pyridalthiadiazole, pyridaloxadiazole, or pyridaltriazole core structure are disclosed. Such compounds can be used in organic heterojunction devices, such as organic small molecule solar cells and transistors.Type: ApplicationFiled: November 22, 2011Publication date: June 19, 2014Applicant: The Regents of the University of CaliforniaInventors: Gregory C. Welch, Corey V. Hoven, Thuc-Quyen Nguyen, Guillermo B. Bazan
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Publication number: 20140171643Abstract: Disclosed are methods for making aldehydes and ketones comprising allowing the corresponding primary or secondary alcohol to react in the presence of trichoroisocyanuric acid, a compound of formula R1SR2 and a base. In one embodiment, the alcohol is a compound of formula (I): wherein R3 is a protecting group. Also disclosed are methods for making 3-O-protected morphine dienol carboxylates comprising allowing a compound of formula (I) to oxidize in the presence of a chlorine-containing compound and a compound of formula R1SR2; and allowing the product of the oxidation step to react with an acylating agent.Type: ApplicationFiled: February 24, 2014Publication date: June 19, 2014Applicant: Purdue Pharma L.P.Inventor: Andreas STUMPF