Carbocyclic Ring Containing Patents (Class 546/191)
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Patent number: 4751073Abstract: 2,2,6,6-tetraalkyl-4-piperidinyl derivatives and, more specifically, the N,N'-bis(2,2,6,6-tetraalkyl-4-piperidene)2,2'-diamino-2,2'-dihydrocarbyl divinyl ketones wherein the alkyl groups have independently from one to about eight carbon atoms and said hydrocarbyl moieties are selected from the group consisting of alkyls having between one and about eight carbon atoms, aryl, alkaryl, and aralkyl groups having between one and about twenty carbon atoms.These compounds are useful as UV light stabilizers in plastics and cosmetics (e.g. sunscreens).Type: GrantFiled: June 3, 1987Date of Patent: June 14, 1988Assignee: Olin CorporationInventor: Robert J. Raynor
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Patent number: 4719218Abstract: A method of inhibiting the production of 5-lipoxygenase products in an animal in need thereof which comprises administering an effective, 5-lipoxygenase pathway inhibiting amount of a 2(3)-(pyridyl)-3-(2)-substituted phenyl)-6,7-dihydro-[5H]-pyrrolo-[1,2-a]imidazole, a 2(3)-(pyridyl)-3(2)-(substituted phenyl)-5,6,7,8-tetrahydro-imidazo[1,2,-a]pyridine, or a pharmaceutically acceptable salt thereof, to such animal.Type: GrantFiled: April 28, 1986Date of Patent: January 12, 1988Assignee: SmithKline Beckman CorporationInventors: Paul E. Bender, Nabil Hanna
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Patent number: 4716187Abstract: both R.sub.1 's and CH.sub.3 or together form --CH.sub.2).sub.5 ;both R.sub.2 's are CH.sub.3 or together form --CH.sub.2).sub.5 ;R.sub.3 has a significance of R, independently of R, except for oxygen;X is --O--, --NH-- or ##STR2## m is an integer from 1 to 4 inclusive; R.sub.4 is a saturated or unsaturated aliphatic group unsubstituted or substituted by one or two groups selected from --OH and C.sub.1-4 alkoxy and which can be interrupted by an oxygen or sulphur atom; or an aromatic group unsubstituted or substituted by one or two groups selected from --OH, C.sub.1-4 alkyl and C.sub.1-4 alkoxy are useful as U.V. light stabilizers in polymeric organic compounds.Type: GrantFiled: March 15, 1985Date of Patent: December 29, 1987Assignee: Sandoz Ltd.Inventor: Lajos Avar
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Patent number: 4707305Abstract: This invention provides a novel class of naphthoquinodimethane compositions. Illustrative of the invention is 11,11-di(n-hexyldecylamino)-12,12-dicyano-2,6-naphthoquinodimethane: ##STR1## An invention naphthoquinodimethane compound has utility as a nonlinear optical component in an electrooptic light modulator device.Type: GrantFiled: May 19, 1986Date of Patent: November 17, 1987Assignee: Celanese CorporationInventors: Eui W. Choe, Alan Buckley, Anthony F. Garito
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Patent number: 4695600Abstract: These compounds are useful as light stabilizers in polymeric systems. ##STR1## in which R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are organic radicals.Type: GrantFiled: June 17, 1986Date of Patent: September 22, 1987Assignee: Sandoz Ltd.Inventor: Lajos Avar
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Patent number: 4670592Abstract: A bisbiguanide compound of the formula:R.sup.1 R.sup.2 N.C(:NR.sup.6)NH.C(:NH)NH.CH.sub.2 X-- --(CH.sub.2).sub.3 NH.C(:NH)NH.C(:NR.sup.7)NR.sup.3 R.sup.4 Vor a tautomer thereof, wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 which may be the same or different, are each hydrogen, a 1-16C alkyl radical, a 2-16C alkoxyalkyl radical, a 3-12C cycloalkyl radical, a (3-12C cycloalkyl)-(1-4C alkyl) radical, or an optionally substituted phenyl or phenyl(1-4C alkyl) radical, or R.sup.1 and R.sup.2 and the nitrogen atom to which they are attached, or R.sup.3 and R.sup.4 and the nitrogen atom to which they are attached, which may be the same or different, are each a 1-azetidinyl, 1-pyrrolidinyl, piperidino, hexamethyleneimino, heptamethyleneimino, morpholino or 4-(1-8C alkanoyl)-1-piperazinyl radical each of which may bear 1-3C alkyl substituents; each of R.sup.6 and R.sup.7, which may be the same or different, is hydrogen or a 1-8C alkyl radical; and X is a substituted ethylene or ethylidene radical of the formula:--CH.Type: GrantFiled: May 7, 1984Date of Patent: June 2, 1987Assignee: Imperial Chemical Industries PLCInventors: Murdoch A. Eakin, Philip N. Edwards, Michael S. Large
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Patent number: 4666905Abstract: Novel chemical compounds which are diphenylmethylene piperidine compounds are provided, as well as methods for their production, pharmaceutical compositions comprising the compounds, and methods of treatment using the compounds in dosage form. The compounds have pharmacological properties especially anticholinergic properties, and are useful as antiemetic, antihistamine, pulmonary, antiallergy, and antispasmodic agents.Type: GrantFiled: September 9, 1986Date of Patent: May 19, 1987Assignee: Warner-Lambert CompanyInventors: David A. Downs, Haile Tecle
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Patent number: 4628094Abstract: Tris(disubstituted amino)sulfonium perfluoroalkoxides and tris(disubstituted amino)sulfonium perfluoroalkylmercaptides and process for their preparation.Type: GrantFiled: June 8, 1984Date of Patent: December 9, 1986Assignee: E. I. Du Pont de Nemours and CompanyInventors: William B. Farnham, William J. Middleton
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Patent number: 4609698Abstract: Oligomeric esters of the formula I or II ##STR1## in which n has a value from 1 to 3, R.sup.1 and R.sup.2 are divalent organic radicals, at least one of which contains a polyalkylpiperidine radical of the formula III ##STR2## in which R is hydrogen or C.sub.1 -C.sub.4 -alkyl and E and E' are end groups, are prepared by polycondensing a dicarboxylic acid ester with a diol, one of the two components being used in a molar excess of 33 to 100%. The end groups of these oligoesters can be modified by reaction with a monofunctional component. If two different dicarboxylic acid esters or diols are used, the corresponding co-oligoesters are obtained. All these oligoesters are valuable light stabilisers for light-sensitive organic material, especially for polymer.Type: GrantFiled: April 26, 1985Date of Patent: September 2, 1986Assignee: Ciba-Geigy CorporationInventors: Friedrich Karrer, Jean Rody
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Patent number: 4607104Abstract: 2,2,6,6-tetraalkyl-4-piperidylamines are produced by reacting an amine with a 2,2,6,6-tetraalkyl-4-piperidone in the presence of a catalyst selected from the group consisting of platinum, nickel and cobalt, employing a reaction medium comprising (a) between about 10 and 100 weight percent water and (b) between 0 and about 90 weight percent of a polar organic compound selected from the group consisting of C.sub.1 -C.sub.10 aliphatic alcohols and C.sub.2 -C.sub.6 aliphatic glycols.Type: GrantFiled: July 11, 1985Date of Patent: August 19, 1986Assignee: Uniroyal Chemical Company, Inc.Inventors: Russell E. Malz, Jr., Harold Greenfield
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Patent number: 4607030Abstract: The invention relates to 2-aminomethylphenols of the formula I ##STR1## in which R.sup.1 and R.sup.2 represent hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl or benzyl which is optionally substituted by alkyl, alkoxy or halogen, R.sup.3 and R.sup.5 denote hydrogen, halogen, alkyl or alkoxy, R.sup.4 denotes halogen, alkyl or cycloalkyl and R.sup.6 and R.sup.7 represents hydrogen or alkyl, it being possible for the radicals R.sup.1 and R.sup.2, R.sup.6 and R.sup.7 and/or two of the radicals R.sup.3, R.sup.4 and R.sup.5 to form an alkylene chain which is optionally substituted by methyl groups and which, in the case of the radicals R.sup.1, R.sup.2, R.sup.6 and R.sup.7, can also be interrupted by oxygen atoms, sulfur atoms and/or imino groups, and to physiologically acceptable salts thereof, a process for their preparation, and their use and to pharmaceutical formulations based on these compounds.Type: GrantFiled: July 3, 1985Date of Patent: August 19, 1986Assignee: Hoechst AktiengesellschaftInventors: Heinrich C. Englert, Dieter Mania, Roman Muschaweck, Max Hropot
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Patent number: 4605743Abstract: 2,2,6,6-tetraalkyl-4-piperidylamines are produced by reacting an amine with a 2,2,6,6-tetraalkyl-4-piperidone in the presence of a palladium catalyst.Type: GrantFiled: April 16, 1985Date of Patent: August 12, 1986Assignee: Uniroyal Chemical Company, Inc.Inventors: Russell E. Malz, Jr., Harold Greenfield
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Patent number: 4602087Abstract: The distyrylbiphenyls of the formula ##STR1## in which X and X' independently of one another are a direct bond, oxygen, sulfur, --O--C.sub.1-3 -alkylene-CON(R.sub.4)--CON(R.sub.4)--, --O--C.sub.1-3 alkylene-COO--, OCO or --COO--, with the proviso that if n+n'=O, X and X' may not be --CON(R.sub.4)-- or O--C.sub.1-3 -alkylene-CON(R.sub.4)--, and if n+n'=2 and X and X' are --CON(R.sub.4)-- or --COO--, A.sup..crclbar. may not be a phosphite or phosphonate anion, and Y and Y' independently of one another are C.sub.1-20 -alkyene, R.sub.1 and R.sub.1 ' independently of one another are unsubstituted or substituted C.sub.1-8 -alkyl or C.sub.3-4 -alkenyl, R.sub.1 together with R.sub.2, or R.sub.1 ' together with R.sub.2 ', is a heterocyclic ring, R.sub.2 and R.sub.2 ' independently of one another are unsubstituted or substituted C.sub.1-8 -alkyl or C.sub.3-4 -alkenyl, or R.sub.2 together with R.sub.1, or R.sub.2 ' together with R.sub.1 ', is a heterocyclic ring, or R.sub.1 and R.sub.2, or R.sub.1 ' and R.sub.Type: GrantFiled: May 18, 1984Date of Patent: July 22, 1986Assignee: Ciba-Geigy CorporationInventors: Christian Luthi, Hans R. Meyer, Kurt Weber
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Patent number: 4587296Abstract: Additives for rubber compositions, giving vulcanisates having improved retention of optimum physical properties, are compounds containing two or more groups of the formula --S--SO.sub.2 R linked by an organic bridging group, or polymers containing two or more groups of the formula --S--SO.sub.2 R attached to an organic polymer chain, where R represents (a) a radical OM where M is a monovalent metal, the equivalent of a multivalent metal, a monovalent in derived by the addition of a proton to a nitrogenous base, or the equivalent of a multivalent ion derived by the addition of two or more protons to a nitrogenous base, or (b) an organic radical selected from aliphatic, cycloaliphatic, aromatic and heterocyclic radicals, and radicals which are combinations of any two or more such radicals.Type: GrantFiled: April 11, 1985Date of Patent: May 6, 1986Assignee: Monsanto Europe, S.A.Inventor: Philippe G. Moniotte
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Patent number: 4567257Abstract: Disclosed is a novel class of amidinium salts having the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, and R.sub.4 when taken individually are independently selected from lower-alkyl, aralkyl and cycloalkyl, and, when taken together with the respective nitrogen atoms to which they are attached, R.sub.1 together with R.sub.2, and R.sub.3 together with R.sub.4 independently represent heterocyclic groups having 5 to 7 ring atoms, R.sub.5, R.sub.6, R.sub.7, and R.sub.8 are independently selected from hydrogen, lower-alkyl, aryl, aralkyl, and cycloalkyl.The amidinium salts are very active catalysts for converting organic isocyanates to products containing isocyanurate and carbodiimide linkages.Type: GrantFiled: January 16, 1984Date of Patent: January 28, 1986Assignee: The Upjohn CompanyInventor: Dale F. Regelman
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Patent number: 4556649Abstract: Insecticidally active novel substituted malonic acid diamide insecticides of the formula ##STR1## wherein R.sup.1 represents aryl or heteroaryl, each of which can optionally be substituted,R.sup.2 represents hydrogen or trialkylsilyl, and represents alkyl, cycloalkyl, alkenyl, alkinyl, aralkyl, alkylcarbonyl, arylcarbonyl, alkoxycarbonyl, aryloxycarbonyl, alkylsulphenyl, arylsulphenyl, alkylsulphonyl, arylsulphonyl, alkylaminosulphonyl, dialkylaminosulphonyl, arylaminosulphonyl or arylalkylaminosulphonyl, each of which can optionally be substituted, and represents radicals of the formula--CO--NR.sup.5 R.sup.6whereinR.sup.5 and R.sup.6 independently of one another represent hydrogen, alkyl, cycloalkyl, aryl, alkylaminocarbonyl, arylaminocarbonyl, alkylcarbonyl, arylcarbonyl, alkoxycarbonyl, aryloxycarbonyl, alkylsulphonyl or arylsulphonyl, it being possible for these radicals to be optionally substituted,R.sup.3 represents hydrogen or the radical R.sup.4,R.sup.7 and R.sup.Type: GrantFiled: December 21, 1984Date of Patent: December 3, 1985Assignee: Bayer AktiengesellschaftInventors: Herbert Salzburg, Rudolf Fauss, Kurt Findeisen, Bernhard Homeyer
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Patent number: 4546148Abstract: Novel polycondensed compounds containing piperidine groups of polycarbamate structure, of the general formula: ##STR1##Type: GrantFiled: July 19, 1984Date of Patent: October 8, 1985Assignee: Ciba-Geigy S.p.A.Inventor: Giuseppe Cantatore
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Patent number: 4540780Abstract: Novel chemical compounds which are diphenylmethylene piperidine compounds are provided, as well as methods for their production, pharmaceutical compositions comprising the compounds, and methods of treatment using the compounds in dosage form. The compounds have both anticholinergic and antidopaminergic properties, and are useful as antiemetic, antihistamine, pulmonary, antiallergy, and antispasmodic agents.Type: GrantFiled: June 2, 1983Date of Patent: September 10, 1985Assignee: Warner-Lambert CompanyInventors: David A. Downs, Haile Tecle
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Patent number: 4535184Abstract: Tris(disubstituted amino)sulfonium perfluorocarbanion salts and process for their preparation.Type: GrantFiled: June 8, 1984Date of Patent: August 13, 1985Assignee: E. I. Du Pont De Nemours and CompanyInventor: William J. Middleton
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Patent number: 4530925Abstract: Compounds are described of the formulae (1a) and (1b) ##STR1## in which: --COR.sup.1 is an ester group,n is 1 or 2,W is C.sub.1-7 alkylene,X is cis or trans --CH.dbd.CH or --CH.sub.2 CH.sub.2 --,Y is a saturated heterocyclic amino group,R.sup.2 is substituted or unsubstituted phenylalkyl, thienylalkyl or naphthylalkyl or cinnamyl, andR.sup.3 is --H or C.sub.1-5 alkanoyl, including their salts.These compounds inhibit blood platelet aggregation and bronchoconstriction and may be formulated for use as antithrombotic or antiasthmatic agents.Type: GrantFiled: March 14, 1984Date of Patent: July 23, 1985Assignee: Glaxo Group LimitedInventors: Eric W. Collington, Peter Hallett, Christopher J. Wallis, John Bradshaw
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Patent number: 4528374Abstract: Novel oligomer or polymer polyamine-1,3,5-triazines containing at least one polyalkylpiperidine radical, for example that of the formula ##STR1## processes for their production, their use for stabilizing organic material, and the organic material protected therewith against oxidative and light-induced degradation.Type: GrantFiled: November 9, 1981Date of Patent: July 9, 1985Assignee: Ciba-Geigy CorporationInventor: Erwin Nikles
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Patent number: 4526971Abstract: A process for producing polyalkylpiperidylamines of the formula (I): ##STR1## wherein R.sub.1 is hydrogen or a C.sub.1 -C.sub.12 alkylradical; R.sub.2 and R.sub.3 are each C.sub.1 -C.sub.5 alkylradicals or R.sub.2 and R.sub.3, taken together, are --(CH)--.sub.a or --CH.sub.2 --NR.sub.1 --C(R.sub.5,R.sub.6)--CH.sub.2 --; R.sub.4 is a C.sub.2 -C.sub.18 alkylene radical, which is unsubstituted or substituted by C.sub.1 -C.sub.3 alkyl; a C.sub.5 -C.sub.12 cycloalkylene radical, which is unsubstituted or is methyl-substituted; a cycloalkylene radical of the formula ##STR2## where the cyclohexyl rings are unsubstituted or are methyl-substituted; or groups of the formula --(CH.sub.2).sub.k --X--[CH.sub.2).sub.m --X]--.sub.n (CH.sub.2).sub.p --, where X is --O--, --NH--, --NR.sub.5 and R.sub.5 and R.sub.6 are each a C.sub.1 -C.sub.Type: GrantFiled: March 30, 1984Date of Patent: July 2, 1985Assignee: Chemische Werke Huls AktiengesellschaftInventors: Josef Disteldorf, Manfred zur Hausen, Werner Hubel, Gunter Kriebel
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Patent number: 4526972Abstract: This invention relates to ultraviolet light stabilizing hindered polyoxyalkylene polyamines. The products of the present invention can be utilized as ultraviolet light stabilizers for a wide variety of commercial products such as water base paints, oil base paints, polyethylenes, polypropylenes, polyurethanes, etc. The products have the formula: ##STR1## wherein: R represents an alkylene, alkyl, aralkyl, alkaryl or aryl group containing 1 to 24 carbon atoms,R' represents hydrogen, methyl or ethyl,n represents a number having an average value of 1 to 70, andx represents an integer having a value of 1 to 3.In a modified form of the invention, the products are useful also to inhibit oxidation of such products.Type: GrantFiled: June 27, 1984Date of Patent: July 2, 1985Assignee: Texaco Inc.Inventors: George P. Speranza, Robert A. Grigsby, Jr.
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Patent number: 4486428Abstract: Bicyclic fused benzenoid compounds of the formula ##STR1## and pharmaceutically acceptable cationic and acid addition salts thereof, where M is O, CH.sub.2 or NR.sub.6 ; R.sub.6 is hydrogen, formyl, carbobenzyloxy or certain carboalkoxyalkyl, alkanoyl, alkyl, aralkyl or aralkylcarbonyl groups;A' is:(1) A where one of A and B is hydrogen such that when A is hydrogen, B is C(R.sub.2 R.sub.3)(CH.sub.2).sub.f Q and f is 1 or 2; when B is hydrogen, A is C(R.sub.2 R.sub.3)(CH.sub.2).sub.f Q and f is 0 or 1, when taken together A and OR.sub.1 form a lactone or certain derivatives thereof;(2) A' is ##STR2## (3) A' is Q.sub.3 ; Q is CO.sub.2 R.sub.7, COR.sub.8, C(OH)R.sub.8 R.sub.9, CN, CONR.sub.12 R.sub.13, CH.sub.2 NR.sub.12 R.sub.13, CH.sub.2 NHCOR.sub.14, CH.sub.2 NHSO.sub.2 R.sub.17 or 5-tetrazoyl;Q.sub.3 is ##STR3## 5-tetrazolyl, CH.sub.2 CONHCOR.sub.7, COOH or certain ester, amide, carboximido or sulfonimido derivatives thereof, CONHOH, CONHCONH.sub.2, or COCH.sub.2 Q.sub.4 where Q.sub.Type: GrantFiled: January 13, 1983Date of Patent: December 4, 1984Assignee: Pfizer Inc.Inventors: James F. Eggler, Michael R. Johnson, Lawrence S. Melvin, Jr.
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Patent number: 4482549Abstract: Compounds are described of the formula ##STR1## in which --COR.sup.1 is a complex ester or thioester group,W is alkylene,X is cis or trans --CH.dbd.CH or --CH.sub.2 CH.sub.2 --,n is 1 or 2,Y is a saturated heterocyclic amino group having 5-8 ring members, andR.sup.2 is unsubstituted or substituted phenylalkyl, thienzlalkyl, naphthylalkyl or cinnamyl, and their salts and solvates.These compounds inhibit blood platelet aggregation and bronchoconstriction and may be formulated for use as antithrombotic and antiasthmatic agents.Type: GrantFiled: February 8, 1984Date of Patent: November 13, 1984Assignee: Glaxo Group LimitedInventors: Eric W. Collington, Peter Hallett, Christopher J. Wallis, Norman F. Hayes, John Bradshaw, Malcolm Carter, Alan Wadsworth
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Patent number: 4481148Abstract: Hydroxyl-containing liquid polymers having an aliphatic polymeric backbone and sulfide linkages near the terminal portions of the polymer molecule are prepared by polymerizing (1) at least one of selected vinylidene monomers having at least one terminal CH.sub.2 .dbd.C< group per monomer molecule, together with (2) at least one hydroxyl-containing disulfide in the presence of (3) ultraviolet radiation.Type: GrantFiled: March 16, 1981Date of Patent: November 6, 1984Assignee: The B. F. Goodrich CompanyInventor: Changkiu K. Riew
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Patent number: 4477616Abstract: Tetra-2,2,6,6-tetramethyl-4-piperidinyl)-3-methyl-5-(1',2'-biscarboxylate)- ethyl-cyclohexane or 3-cyclohexene-1,2-dicarboxylates are provided having the formula (I) or (II): ##STR1## wherein: R.sub.1 is selected from the group consisting of hydrogen, --O, alkyl, hydroxy alkyl and epoxyalkyl having from one to about eighteen carbon atoms, acyl having from one to about eighteen carbon atoms, cycloalkyl having from three to about eighteen carbon atoms; phenyl; phenalkyl and alkylphenyl having from seven to about twenty-four carbon atoms;R.sub.2 is lower alkyl having from one to about six carbon atoms; andX is selected from the group consisting of: ##STR2## as well as stabilized synthetic resin compositions comprising such piperidinyl compounds.Type: GrantFiled: March 3, 1983Date of Patent: October 16, 1984Assignee: Adeka Argus Chemical Co., Ltd.Inventors: Motonobu Minagawa, Yutaka Nakahara, Toshihiro Shibata
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Patent number: 4468352Abstract: The distyrylbiphenyls of the formula ##STR1## in which X and X' independently of one another are a direct bond, oxygen, sulfur, --O--C.sub.1-3 -alkylene-CON(R.sub.4)----CON(R.sub.4)--, --O--C.sub.1-3 -alkylene-COO--, OCO or --COO--, with the proviso that if n+n'=O, X and Y' may not be --CON(R.sub.4)-- or O--C.sub.1-3 -alkylene-CON(R.sub.4)--, and if n+n'=2 and X and X' are --CON(R.sub.4)-- or --COO--, A.sup..crclbar. may not be a phosphite or phosphonate anion, and Y and Y' independently of one another are C.sub.1-20 -alkylene, R.sub.1 and R.sub.1 ' independently of one another are unsubstituted or substituted C.sub.1-8 -alkyl or C.sub.3-4 -alkenyl, or R.sub.1 together with R.sub.2, or R.sub.1 ' together with R.sub.2 ', is a heterocyclic ring, R.sub.2 and R.sub.2 ' independently of one another are unsubstituted or substituted C.sub.1-8 -alkyl or C.sub.3-4 -alkenyl, or R.sub.2 together with R.sub.1, or R.sub.2 ' together with R.sub.1 ', is a heterocyclic ring, or R.sub.1 and R.sub.2, or R.sub.1 ' and R.sub.Type: GrantFiled: April 28, 1982Date of Patent: August 28, 1984Assignee: Ciba-Geigy CorporationInventors: Christian Luthi, Hans R. Meyer, Kurt Weber
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Patent number: 4468243Abstract: Formamidine sulphides and disulphides endowed with herbicide activity are disclosed.The processes for their preparation, their use as herbicides and herbicidal compositions thereof are disclosed too.Type: GrantFiled: March 9, 1982Date of Patent: August 28, 1984Assignee: Montedison S.p.A.Inventors: Roberto Colle, Franco Gozzo, Ciro Preziuso
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Patent number: 4463001Abstract: The present invention relates to new 6-substituted 6H-dibenzo [b,d]pyran derivatives, to a process for their preparation and pharmaceutical and veterinary compositions containing them.Type: GrantFiled: October 1, 1981Date of Patent: July 31, 1984Assignee: Farmitalia Carlo Erba S.p.A.Inventors: Piero Melloni, Paolo Salvadori, Pier P. Lovisolo
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Patent number: 4460725Abstract: Polyethers containing 2,2,6,6-tetramethyl piperidinyl carboxylic acid ester or ether groups are provided, comprising polymeric units having the structure ##STR1## wherein X is selected from the group consisting of: ##STR2## R.sub.1 is selected from the group consisting of hydrogen, --O, alkyl, hydroxy alkyl and epoxyalkyl having from one to about eighteen carbon atoms, acyl having from one to about eighteen carbon atoms, cycloalkyl having from three to about eighteen carbon atoms; phenyl; phenalkyl and alkylphenyl having from seven to about twenty-four carbon atoms;R.sub.2 is hydrogen or hydroxy;n.sub.1 is 0 or 1;R.sub.3 is lower alkyl having from one to about six carbon atoms; andn is the average number of such units in the polymer; as well as stabilized synthetic resin compositions comprising such polyethers.Type: GrantFiled: March 7, 1983Date of Patent: July 17, 1984Inventors: William E. Leistner, Motonobu Minagawa, Naohiro Kubota, Toshihiro Shibata, Ryozo Arata
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Patent number: 4444928Abstract: Polymers or oligometic compounds of the general formula ##STR1## in which X, X.sup.a and X.sup.b are an ester, amide or cyano group, Y, Y.sup.a and Y.sup.b are --O-- or --NR.sup.10 --, R.sup.1, R.sup.1a and R.sup.1b are a group which contains a polyalkylpiperidine radical, and R.sup.1a can also be alkyl, and R.sup.3, R.sup.3a and R.sup.3b are alkylene, alkenylene, arylene-dialkylene, cycloalkylene-dialkylene or monooxa-alkylene or polyoxa-alkylene, can be prepared by the polycondensation of malonic acid esters or amides or cyanoacetic acid esters or amides with difunctional compounds, preferably dihalogen compounds, in the presence of bases. The products obtained have a molecular weight of 800 to 20,000 and are outstanding light stabilizers for organic polymers.Type: GrantFiled: August 4, 1982Date of Patent: April 24, 1984Assignee: Ciba-Geigy CorporationInventor: Friedrich Karrer
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Patent number: 4434295Abstract: The present specification provides novel analogs of khellin. These analogs are all useful as antiatherosclerotic agents. Particularly, the present specification provides 4-methoxy, 9-methoxy, or 4,9-dimethoxy-6,7-dihydro-7,7-disubstituted-5H-furo[3,2-g][1]benzopyran-5- ones.Type: GrantFiled: May 17, 1982Date of Patent: February 28, 1984Assignee: The Upjohn CompanyInventor: Ronald B. Gammill
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Patent number: 4419354Abstract: This disclosure describes certain substituted 9,10-bis(2-aminoethoxy)anthracenes which are useful as modulators of the immune response system in warm-blooded animals and for inducing the regression of tumors in such animals.Type: GrantFiled: June 3, 1982Date of Patent: December 6, 1983Assignee: American Cyanamid CompanyInventors: Ralph G. Child, Stanley A. Lang, Jr.
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Patent number: 4414018Abstract: Formamidine sulphides and disulphides endowed with herbicide activity are disclosed.The processes for their preparation, their use as herbicides and herbicidal compositions thereof are disclosed too.Type: GrantFiled: March 9, 1982Date of Patent: November 8, 1983Assignee: Montedison S.p.A.Inventors: Roberto Colle, Franco Gozzo, Ciro Preziuso
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Patent number: 4414220Abstract: A series of organic diamine base compounds derived from either an aromatic, alicyclic or heterocyclic ring and possessing, for the most part, an intervening methylene group between the ring and the aforesaid basic moiety have been prepared, including their pharmaceutically acceptable acid addition salts as well as oral pharmaceutical compositions containing same. These particular compounds are found to be useful in therapy as oral hypoglycemic agents. Preferred member compounds include 1,1'-[1,2-phenylenebis(methylene)]bispiperidine, 2,3-dihydro-2-[2-(1-piperidinomethyl)phenylmethyl]-1H-isoindole and 2,3-dihydro-2-[2-(4-morpholinomethyl)phenylmethyl]-1H-isoindole. Alternate methods of preparation are provided and the two principal synthetic routes leading to these compounds are described in some detail.Type: GrantFiled: March 1, 1982Date of Patent: November 8, 1983Assignee: Pfizer Inc.Inventor: John L. Belletire
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Patent number: 4410521Abstract: Compounds are described of the formula ##STR1## in which --COR.sup.1 is a complex ester or thioester group,W is alkylene,X is cis or trans --CH.dbd.CH or --CH.sub.2 CH.sub.2 --,n is 1 or 2,Y is a saturated heterocyclic amino group having 5-8 ring members, andR.sup.2 is unsubstituted or substituted phenylalkyl, thienylalkyl, naphthylalkyl or cinnamyl,and their salts and solvates.These compounds inhibit blood platelet aggregation and bronchoconstruction and may be formulated for use as antithrombotic and antiasthmatic agents.Type: GrantFiled: September 16, 1982Date of Patent: October 18, 1983Assignee: Glaxo Group LimitedInventors: Eric W. Collington, Peter Hallett, Christopher J. Wallis, Norman F. Hayes, John Bradshaw, Malcolm Carter
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Patent number: 4405737Abstract: N-2-Hydroxypropyl piperidines are provided, as well as a process for preparing these compounds, having the formula: ##STR1## wherein X is selected from the group consisting of , ##STR2## wherein R.sub.1 is selected from the group consisting of hydrogen; alkyl; alkenyl; cycloalkyl; alkaryl; hydroxyalkyl; oxyalkyl; acyl and aroyl having from one to about eighteen carbon atoms;R.sub.2 and R.sub.3 are each selected from the group consisting of alkyl, alkenyl, cycloalkyl, alkaryl, hydroxyalkyl, oxyalkyl and haloalkyl having from one to about eighteen carbon atoms;R.sub.4, R.sub.5 and R.sub.6 each are selected from the group consisting of hydrogen, alkyl, alkenyl, cycloalkyl, alkaryl, hydroxyalkyl, oxyalkyl and haloalkyl having from one to about eighteen carbon atoms; and --CH.sub.2 --O--R.sub.1 ;n is 1 or 2; andY, when n is 1, is hydroxy or ##STR3## and when n is 2, is oxyoxygen.Type: GrantFiled: February 5, 1982Date of Patent: September 20, 1983Assignee: Adeka Argus Chemical Co., Ltd.Inventors: Bunji Hirai, Naohiro Kubota, Kazuo Sugibuchi
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Patent number: 4377690Abstract: Novel ligands of the general formula wherein r is 1 or 2, and L is a piperidine which is substituted by at least one enolate group in the 1-position or 4-position and wherein the ring nitrogen is sterically hindered by alkyl substituents in the adjacent positions. These ligands are useful in preparing light stabilizers.Type: GrantFiled: June 8, 1981Date of Patent: March 22, 1983Assignee: Ciba-Geigy CorporationInventor: Paul Moser
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Patent number: 4374271Abstract: N-Amino substituted aniline and 1,3-phenylenediamine compounds having 1 or 2 nitro groups on the aromatic ring. The compounds are useful as herbicides and as intermediates for preparing herbicides.Type: GrantFiled: April 4, 1979Date of Patent: February 15, 1983Assignee: United States Borax & Chemical CorporationInventors: Don L. Hunter, William G. Woods, James D. Stone, Cecil W. LeFevre
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Patent number: 4370430Abstract: Oligomers of the formula ##STR1## which contain at least one piperidyl radical per repeating unit are useful as light stabilizers for polymers.Type: GrantFiled: August 31, 1981Date of Patent: January 25, 1983Assignee: American Cyanamid CompanyInventor: Joseph A. Hoffman
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Patent number: 4358450Abstract: Compounds of general formula ##STR1## wherein R.sup.1 represents a member selected from the group consisting of (a) an unsubstituted at most binuclear aryl group having from 6 to 10 carbon atoms, such groups substituted by from 1 to 3 equal or different radicals selected from the group consisting of alkyl, halogenoalkyl, alkoxy, dialkylamino each having up to 4 carbon atoms in the alkyl moiety, halogen phenyl, carboxyl, cyano, nitro and hydroxy groups,(b) a 5- to 6-membered heteroaromatic ring wherein the heteroatom is selected from nitrogen, oxygen and sulfur atoms and such rings anellated to a benzene nucleus;R.sup.2 represents a member selected from the group consisting of hydrogen, alkyl having up to 3 carbon atoms, phenyl, cycloalkyl having up to 6 carbon atoms in the ring and cycloalkyl bearing a hydrocarbon bridging radical having up to 2 carbon atoms;R.sup.3 represents hydrogen, hydroxy or acyloxy;R.sup.4 and R.sup.Type: GrantFiled: August 6, 1979Date of Patent: November 9, 1982Assignee: Hoechst AktiengesellschaftInventors: Ulrich Gebert, Ernold Granzer, Heinz-Gunter Greve, Werner Thorwart
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Patent number: 4348330Abstract: A process for the production of a sulphinate of formula ##STR1## which comprises reacting a compound of formula ##STR2## or a mixture of the compounds of formulae (2a) and (2b) with a compound of formulaY--SO.sub.2 --M (3)in an organic solvent in the presence of a mineral acid or organic acid and, optionally, also of water, wherein Ar.sub.1 and Ar.sub.2 are the same or different and each represents an unsubstituted or substituted aromatic carbocyclic radical.R.sub.1, R.sub.2, R.sub.3 and R.sub.4 independently of one another represent hydrogen, C.sub.1 -C.sub.12 -alkyl, C.sub.2 -C.sub.8 -alkoxyalkyl, cycloalkyl, aralkyl, aryl, or substituted alkyl, cycloalkyl, aralkyl or aryl, or each of the pairs of substituents (R.sub.1 and R.sub.2) and (R.sub.3 and R.sub.4), together with the nitrogen atom to which said pair is attached, independently, represents a heterocyclic ring, or one of several of the substituents R.sub.1, R.sub.2, R.sub.3 and R.sub.4 with the nitrogen and an adajcent carbon atom of the residue Ar.Type: GrantFiled: February 6, 1981Date of Patent: September 7, 1982Assignee: Ciba-Geigy CorporationInventors: Malcolm C. Clark, John B. Henshall
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Patent number: 4341904Abstract: Novel amino derivatives of 2-hydroxy-6,9-methano-11-amino-5,6,7,8,9,10-hexahydro-benzocyclooctenes, methods for their preparation, and their use as effective analgesic agents is described.Type: GrantFiled: February 19, 1980Date of Patent: July 27, 1982Assignee: Merck & Co., Inc.Inventors: Patrice C. Belanger, Robert N. Young
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Patent number: 4339576Abstract: 1-[(3- or 4-Benzoylphenyl)-lower-alkyl]-[(CH.sub.2).sub.n --N.dbd.B]-substituted-piperidines, useful as anti-asthmatic, anti-allergic, anti-cholinergic, bronchodilator and anti-inflammatory agents, are prepared by alkylation of an appropriate substituted piperidine with a (3- or 4-benzoylphenyl)-lower-alkyl halide or tosylate; by reaction of a 1-[2-(3- or 4-lithiophenyl)-lower-alkyl]-[(CH.sub.2).sub.n --N.dbd.B]-substituted-piperidine with benzonitrile and hydrolysis of the resulting benzimidoyl compound; or by reduction of a 1-[.alpha.-(3- or 4-benzoylphenyl)-lower-alkanoyl]-[(CH.sub.2).sub.n --N.dbd.B]-substituted-piperidine. The analogous carbinols are prepared by reduction, with an alkali metal borohydride, of the ketone.Type: GrantFiled: August 24, 1981Date of Patent: July 13, 1982Assignee: Sterling Drug Inc.Inventor: Bernard L. Zenitz
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Patent number: 4332941Abstract: Cyclohexanones and -hexenones ##STR1## R.sup.1 is hydrogen or--CO--O--C.sub.n H.sub.2n+1-m (--NR.sup.4 R.sup.5) (1c)R.sup.2 is a group 1c, R.sup.3 is C.sub.1 - to C.sub.10 -alkyl, phenyl or phenyl substituted by lower alkyl, lower alkoxy, trifluoromethyl, nitro, cyano, chloro, carbamoyl, lower-alkyl-carbamoyl, sulfamoyl or lower-alkyl-sulfamoyl, R.sup.4 and R.sup.5 are lower alkyl or --NR.sup.4 R.sup.5 is pyrrolidinyl, piperidyl or morpholyl, m is 1 or 2 and n is 2 to 6, are obtained by reacting 2 mols of an esterCH.sub.3 --CO--CH.sub.2 --CO--O--C.sub.n H.sub.2n+1-m (--NR.sup.4 R.sup.5).sub.m (2)with an aldehyde R.sup.3 --CHO (3). The compounds (1) easily saponify and decarboxylate without an added catalyst to form a cyclohexenones ##STR2## while setting free the alcoholHO--C.sub.n H.sub.2n+1-m (--NR.sup.4 R.sup.5).sub.m (5)which reacts without a catalyst with diketene to form the ester (2).Type: GrantFiled: October 10, 1980Date of Patent: June 1, 1982Assignee: Hoechst AktiengesellschaftInventors: Rudiger Berthold, Werner H. Muller
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Patent number: 4326063Abstract: Process for the selective reductive alkylation of a cyclic diamine by catalytic condensation of the cyclic diamine with a hetercyclic ketone. In the process described herein, the reaction conditions and catalyst which are selected are directive for the synthesis of the N,N' substituted cyclic diamine. The compounds produced according to this procedure are readily isolated and are effective as UV stabilizers.Type: GrantFiled: July 24, 1980Date of Patent: April 20, 1982Assignee: The B. F. Goodrich CompanyInventor: Pyong-Nae Son
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Patent number: 4317819Abstract: The invention provides compounds of general formula ##STR1## and physiologically acceptable salts, hydrates and bioprecursors thereof, in whichY and Z, which may be the same or different, each represent oxygen, sulphur, .dbd.CHNO.sub.2 or .dbd.NR.sub.3 where R.sub.3 is hydrogen, nitro, cyano, lower alkyl, aryl, alkylsulphonyl or arylsulphonyl;p has a value from 2 to 12;R.sub.1 represents ##STR2## in which R.sub.4 and R.sub.5 which may be the same or different, each represent hydrogen, lower alkyl, cycloalkyl, lower alkenyl, aralkyl or lower alkyl interrupted by an oxygen atom or a group >N-R.sub.6 in which R.sub.6 represents hydrogen or lower alkyl, or R.sub.4 and R.sub.5 together with the nitrogen atom to which they are attached form a 5 to 7-membered saturated heterocyclic ring which may contain an additional oxygen atom or the group >NR.sub.Type: GrantFiled: December 5, 1980Date of Patent: March 2, 1982Assignee: Glaxo Group LimitedInventors: John W. Clitherow, Barry J. Price, John Bradshaw, Michael Martin-Smith
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Patent number: 4265803Abstract: The invention entitled "Polymers containing polyalkylpiperidines and use thereof as stabilizers" provides a class of polymers in which groups containing sterically hindered polyalkylpiperidines are linked in the main chain of the polymers via bridging members containing 2-hydroxy-1,3-trimethylene groups.The polymers show superior stabilizing effects for various synthetic polymers such as polyolefins against degradation thereof induced by light and/or heat. The polymers have advantages, as compared with known stabilizer compounds, that they hardly volatile upon processing with heating or during storage of articles containing thereof, and that they are resistant to extraction with solvents from articles containing thereof.Type: GrantFiled: August 7, 1978Date of Patent: May 5, 1981Assignee: Sankyo Company LimitedInventors: Nobuo Soma, Syoji Morimura, Takao Yoshioka, Tomoyuki Kurumada
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Patent number: 4260749Abstract: 2,5-diamino-1,4-benzoquinones are used in the production of hair dye compositions and can be prepared by condensing a corresponding 3-amino-4-methoxy phenol derivative on one of a corresponding hydroxy aniline or phenylenediamine derivative, a corresponding benzoquinone imine derivative or a corresponding nitroso derivative.Type: GrantFiled: May 9, 1980Date of Patent: April 7, 1981Assignee: L'OrealInventors: Andree Bugaut, Monique Laudon