Acyclic Nitrogen Bonded Directly To A -c(=x)- Group, Wherein X Is Chalcogen Patents (Class 546/336)
  • Patent number: 4431810
    Abstract: Hypoglycemic 5-chromanyl, 2,3-dihydro-5-benzo[b]furanyl, 5-pyridyl, 5-quinolyl, 5-pyrrolyl, 5-indolyl, 5-thiazolyl, 5-oxazolyl, 5-isothiazolyl and 5-isoxazolyl oxazolidine-2,4-diones and the pharmaceutically-acceptable salts thereof; certain 3-acylated derivatives thereof; a method of treating hyperglycemic animals therewith; and intermediates useful in the preparation of said compounds.
    Type: Grant
    Filed: May 20, 1982
    Date of Patent: February 14, 1984
    Assignee: Pfizer Inc.
    Inventor: Rodney C. Schnur
  • Patent number: 4419363
    Abstract: Novel 1-aryloxy-3-amidoamidoalkylamino-2-propanol derivatives, processes for their manufacture, pharmaceutical compositions containing them and methods of using them in the treatment of heart diseases. Representative of the compounds disclosed is 1-(o-cyanophenoxy)-3-.beta.-(2-thenamidoacetamido)ethylaminopropan-2-ol.
    Type: Grant
    Filed: June 4, 1982
    Date of Patent: December 6, 1983
    Assignee: Imperial Chemical Industries PLC
    Inventor: Leslie H. Smith
  • Patent number: 4358606
    Abstract: Novel esters of phenylalkyloxy- or phenylalkylthioacylamino acids and pyridylalkyloxy- or pyridylalkylthioacylamino acids, synthesis thereof, intermediates therefor, and the use of said esters for the control of weeds.
    Type: Grant
    Filed: June 19, 1981
    Date of Patent: November 9, 1982
    Assignee: Zoecon Corporation
    Inventors: Shy-Fuh Lee, Clive A. Henrick
  • Patent number: 4356177
    Abstract: The present invention relates to new pyridine derivatives of formula: ##STR1## wherein R.sub.1 is an alkyl or an alicyclic group, R.sub.2 and R.sub.3 are alkyls or alicyclic groups or form an heterocycle with the atom of nitrogen to which they are bonded; the invention also relates to a process for the preparation of said derivatives and the medicines containing at least one of the said derivatives.
    Type: Grant
    Filed: October 7, 1980
    Date of Patent: October 26, 1982
    Assignee: C.M. Industries
    Inventors: Henri Demarne, Claude Bernhart, Jacqueline Lansen
  • Patent number: 4350518
    Abstract: Substituted alkylammonium salts of the formula ##STR1## where Ar denotes substituted phenyl, X denotes oxygen or sulfur, n denotes one of the integers 0, 1 and 2, B denotes bicyclic quinuclidine, bicyclic pyrrolizidine or substituted ammonium, and Z denotes the anion of a nonphytotoxic acid, the manufacture of these compounds, and their use as plant growth regulators.
    Type: Grant
    Filed: February 23, 1981
    Date of Patent: September 21, 1982
    Assignee: BASF Aktiengesellschaft
    Inventors: Hubert Sauter, Bernd Zeeh, Ernst Buschmann, Johann Jung
  • Patent number: 4350699
    Abstract: A novel class of chemical compounds useful as pesticides consists of pyridylalkoxysulfinyl derivatives of carbamate esters. The preparation of these compounds and their formulation to control insects are exemplified.
    Type: Grant
    Filed: March 30, 1981
    Date of Patent: September 21, 1982
    Assignee: The Regents of the University of California
    Inventors: Mohamed A. H. Fahmy, Tetsuo R. Fukuto, Teruomi Jojima
  • Patent number: 4348523
    Abstract: Useful thionamide compounds are prepared by reacting sulfur with imines of the structural formula: ##STR1## where R is an alkyl group of 1 to 18 carbon atoms and is other than a phenyl or cyclohexyl group, R.sub.1 and R.sub.2 are alkyl or phenyl groups of 1 to 18 carbon atoms, and R.sub.3 is a phenyl group of 6 to 18 carbon atoms or is hydrogen, in the presence of a diol or triol compound. The total number of carbons in R, R.sub.1, R.sub.2, and R.sub.3 does not exceed 36 in number.
    Type: Grant
    Filed: September 8, 1980
    Date of Patent: September 7, 1982
    Assignee: Ashland Oil, Inc.
    Inventor: Theodore C. Shields
  • Patent number: 4347372
    Abstract: A process for protecting cultivated plants against aggressive agricultural chemicals is described in which oxime derivatives of the formula ##STR1## are used as antidotes. Either the cultivated area for the cultivated plants or the cultivated plants themselves or parts of the plant (seeds, tubers, stem parts and the like), as desired, can be treated with these oxime derivatives, which are used as a dressing.
    Type: Grant
    Filed: August 28, 1979
    Date of Patent: August 31, 1982
    Assignee: Ciba-Geigy Corporation
    Inventors: Alfons Lukaszczyk, Henry Martin, Peter J. Diel, Werner Fory, Karl Gatzi, Haukur Kristinsson, Beat Muller, Rene Muntwyler, Johannes P. Pachlatko, Hermann Rempfler, Rolf Schurter, Henry Szczepanski
  • Patent number: 4317827
    Abstract: Disclosed and claimed are a cardiac composition and a method for increasing cardiac contractility using an effective amount of a cardiotonic 4-[4-(or 3)-AcNH-phenyl]-2-R.sub.2 -3-R.sub.3 -5-R.sub.5 -6-R.sub.6 -pyridine (I) or pharmaceutically-acceptable salt thereof, where R.sub.2 is hydrogen, methyl, ethyl or hydroxyl, R.sub.6 is hydrogen, methyl or ethyl, R.sub.3 and R.sub.5 are each hydrogen or methyl, and Ac is hydrogen, hydroxyacetyl, acetoxyacetyl, .alpha.-hydroxypropionyl, .alpha.-acetoxypropionyl, methyoxyacetyl, 2-butenoyl or carbamyl or when NHAc is attached to the 4-position of the phenyl ring Ac also is formyl, n-propanoyl, 2,2-dimethyl-n-propanoyl or 3-carboxypropanoyl or when NHAc is attached to the 3-position of the phenyl ring Ac also is acetyl. Novel compounds shown and claimed are 4-[4-(or 3)-Ac'NH-phenyl]-2-R.sub.2 -3-R.sub.3 -5-R.sub.5 -6-R.sub.6 -pyridines (II) or pharmaceutically-acceptable acid-addition salts thereof, where R.sub.2, R.sub.3, R.sub.5 and R.sub.
    Type: Grant
    Filed: May 27, 1980
    Date of Patent: March 2, 1982
    Assignee: Sterling Drug Inc.
    Inventors: George Y. Lesher, Donald F. Page
  • Patent number: 4304916
    Abstract: A process for manufacturing sulfoxide compounds is described herein. The process involves the reaction of certain thiocarbamic acid esters with an oxidizing agent at reduced temperatures.
    Type: Grant
    Filed: September 13, 1976
    Date of Patent: December 8, 1981
    Assignee: Stauffer Chemical Company
    Inventor: Francis H. Walker
  • Patent number: 4289778
    Abstract: 2-(Substituted imino)-N-(3-substituted phenyl)-3-thiazolidinecarbothioamides, useful as insecticides.
    Type: Grant
    Filed: December 27, 1977
    Date of Patent: September 15, 1981
    Assignee: Eli Lilly and Company
    Inventor: Terry W. Balko
  • Patent number: 4288592
    Abstract: There is provided a process for preparing amides which comprises reacting an amine, or an amide, and an acid halide, or anhydride, in suitable molecular proportions, in an inert organic diluent, in the presence of an effective amount of a molecular sieve, until the reaction is completed, separating the molecular sieve, and recovering the amide from the organic mother liquor.
    Type: Grant
    Filed: April 30, 1979
    Date of Patent: September 8, 1981
    Assignee: American Cyanamid Company
    Inventors: Michael M. Rauhut, Shin-Shyong Tseng
  • Patent number: 4283541
    Abstract: Compounds of the formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are independently hydrogen, lower alkyl, phenyl or phenyl-lower alkyl,n is an integer from 1 to 5, andm is an integer from 2 to 5 have antiarrhythmic activity.
    Type: Grant
    Filed: May 27, 1980
    Date of Patent: August 11, 1981
    Assignee: USV Pharmaceutical Corporation
    Inventors: James R. Shroff, Rohit Desai
  • Patent number: 4269834
    Abstract: A method of combatting mycoplasma infections by treatment with copper complexes of certain phenanthroline, isoquinoline and quinazoline derivatives. A number of the complexes and ligand compounds are novel, therapeutically useful substances. Processes for their preparation are described.
    Type: Grant
    Filed: June 19, 1978
    Date of Patent: May 26, 1981
    Inventor: Wijbe T. Nauta
  • Patent number: 4256896
    Abstract: A naphtholactam dyestuff of the general formula (1) ##STR1## in which R represents C.sub.1 -C.sub.5 -alkyl, C.sub.1 -C.sub.5 -alkenyl, C.sub.6 -C.sub.9 -cycloalkyl, C.sub.6 -C.sub.9 -aralkyl, aryl or, preferably, hydrogen, X represents --COOH, --COO.sup..crclbar. cation.sup..sym., a modified carboxyl group, the radical --SO.sub.2 --T or a heterocyclic radical, T denoting alkyl, alkenyl or, preferably, aryl, M represents hydrogen or a cation, Y represents a free or modified carboxyl group, Z is C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -alkoxy, Cl, Br, NO.sub.2, phenyl sulphonyl C.sub.1 -C.sub.4 -alkyl-S, C.sub.1 -C.sub.4 -alkyl sulphonyl, cyano, CONH.sub.2, CONH-C.sub.1 -C.sub.4 -alkyl, and CON(C.sub.1 -C.sub.4 -alkyl).sub.2, n represents 0, 1 or 2, A represents a heterocyclic radical or --CN and B and C can carry further non-ionic substituents.The new dyestuffs give brilliant yellow and red shades on polyester and polyamide fibers.
    Type: Grant
    Filed: September 29, 1978
    Date of Patent: March 17, 1981
    Assignee: Ciba-Geigy Aktiengesellschaft
    Inventors: Hansrudolf Schwander, Christian Zickendraht
  • Patent number: 4216225
    Abstract: Methylmethioninesulfonium compounds of the formula ##STR1## wherein X.crclbar. represents an anion;R.sup.1 represents a hydrogen atom or an acyl group of the formula -COR.sup.3 in which R.sup.3 represents an alkyl group with 1 to 20 carbon atoms, the group --CH.sub.2).sub.2 COOH or the group ##STR2## in which Z represents a direct bond or a methylene or vinylene linkage, Y represents C or N, R.sup.4 represents a member selected from the class consisting of a hydrogen atom, lower alkyl groups, lower alkoxy groups, di-lower-alkylamino groups and a sulfamoyl group, n is a number of 1 to 3, and two or more R.sup.4 groups may be identical or different; andR.sup.2 represents the group --COOR.sup.5 in which R.sup.5 represents a hydrogen atom, an alkyl group with 1 to 5 carbon atoms or a metal- or metal complex-forming moiety, or the group ##STR3## in which R.sup.6 groups may be identical or different, and each represent a hydrogen atom or an alkyl group with 1 to 5 carbon atoms, with the proviso that when R.sup.
    Type: Grant
    Filed: May 16, 1978
    Date of Patent: August 5, 1980
    Assignee: Kowa Company, Ltd.
    Inventors: Masami Shiratsuchi, Kiyoshi Kawamura, Hisashi Kunieda, Naoki Machida, Toshihiro Akashi, Masahiko Nagakura