Abstract: The present invention provides a palladium(II) complex of formula (1) or a palladium(II) complex of formula (2). R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R18, R19, R20, R21, R22, R23 and R24, m, E and X are described in the specification. The invention also provides a process for the preparation of the complexes, and their use in carbon-carbon and carbon-heteroatom coupling reactions.

Abstract: A method for separating and purifying 2-chloro-3-trifluoromethylpyridine useful as an intermediate for medicines, agrochemicals, and the like is provided. The method includes: 1) in the process of producing chloro ?-trifluoromethylpyridine compounds by allowing a ?-methylpyridine compound to react with chlorine and hydrogen fluoride in a reaction apparatus, allowing a ?-trifluoromethylpyridine compound to react with chlorine in a reaction apparatus, or allowing a chloro ?-trichloromethylpyridine compound to react with hydrogen fluoride in a reaction apparatus, 2) fractionating a liquid mixture containing chloro ?-trifluoromethylpyridine compounds from the reaction apparatus, and 3) separating and purifying 2-chloro-3-trifluoromethylpyridine from the liquid mixture.

Abstract: A palladium(II) complex of formula (1) or a palladium(II) complex of formula (2). Also, a process for the preparation of the complexes, and their use in carbon-carbon and carbon-heteroatom coupling reactions.

Abstract: Chelation directed C—H activation reactions that are catalyzed by Pd(11) on Multi-Walled Carbon Nanotubes (MWCNT), Single-Walled Carbon Nanotubes (SWCNT), or graphene are provided. The reactions are used to directly and regioselectively or regiospecifically functionalize specific C—H bonds, e.g. to build complexity into small molecules. Features and advantages of the present invention will be set forth in the description of invention that follows, and in part will be apparent from the description or may be learned by practice of the invention. The invention will be realized and attained by the compositions and methods particularly pointed out in the written description and claims hereof.

Abstract: An object of the present invention is to enable the synthesis of various fluorine-containing compounds having an organic group at both terminals of their tetrafluoroethylene structure (—CF2—CF2—). The present invention provides a fluorine-containing complex compound including a fluorine-containing organic metal compound represented by formula (1a): R1—CF2—CF2-M1??(1a) wherein M1 is a metal selected from the group consisting of copper, zinc, nickel, iron, cobalt, and tin; and R1 represents an organic group, and at least one ligand selected from the group consisting of pyridine ring-containing compounds and phosphines.

Abstract: To provide a novel liquid crystal compound having general physical properties necessary for the compound, namely, stability to heat, light and so forth, a wide temperature range of a liquid crystal phase, a high clearing point, a good compatibility with other compounds, a large refractive index anisotropy, a large dielectric anisotropy and a small viscosity. The liquid crystal compound is provided as compound (1): wherein, for example, R1 is alkyl having 1 to 20 carbons; ring A1 and ring B1 are 1,4-cyclohexylene or 1,4-phenylene; Z1 and Z2 are a single bond, —CH2CH2—, —CH?CH— or —C?C—; L1 is fluorine; L2, Y1 and Y2 are hydrogen, fluorine or chlorine; and X1 is halogen, —C?N or alkyl having 1 to 10 carbons, and in the alkyl, arbitrary —CH2— may be replaced by —O— or —S—, and m is 1 and n is 0.

Abstract: Disclosed is a method for producing an optically active 2-arylpiperidinium salt, comprising asymmetrically hydrogenating a pyridinium salt in the presence of an iridium complex and hydrogen, the 2-arylpiperidinium salt being represented by the following general formula (1): wherein R1, R2, X, *, and m are as described in Description, the pyridinium salt being represented by the following general formula (2): wherein R1, R2, X, and m are as described in Description, and the iridium complex being represented by the following general formula (3): IrH(Z)(Q)(PP*)??(3), wherein Z, PP*, and Q are as described in Description, or the following general formula (4): [{IrH(PP*)}2(?-Z)3]Z??(4), wherein Z and PP* are as described in Description.

Abstract: The present invention provides compounds having the formula A: (A) or pharmaceutically acceptable salt thereof, wherein W, R1, R2 and R5 are as defined in classes and subclasses herein, and pharmaceutical compositions thereof, as described generally and in subclasses herein, which compounds are useful as cytotoxic agents towards proliferating and/or quiescent cancer stem cells, and thus are useful, for example, for the treatment of cancer.

Abstract: The present invention relates to a smectic A phase liquid crystal material, which contains at least one heterocyclic compound. The smectic A phase liquid crystal material of the present invention may further contain at least one ester compound and an ionic compound. By using the smectic A phase liquid crystal material in a display device, a displayed image can be completely erased without any residual images after a long-term placement or a long-term drive, the contrast is generally higher than 10, and the drive voltage is generally 20 to 50 V.

Abstract: Described are GCF-8 inhibitors of the formula (I), and pharmaceutically acceptable salts thereof, wherein n, R1, R2, R5, R6, X and Z are defined herein. Also provided are pharmaceutical compositions comprising the same. Such compounds and compositions are useful in methods for inhibiting GDF-8 in a cell and methods for treating a patient suffering from a disease or disorder, wherein the patient would therapeutically benefit from an increase in mass or strength of muscle tissue.

Abstract: The invention relates to palladium(0) tris{tri-[3,5-bis(trifluoromethyl)-phenyl]-phosphine} complex of formula (I), as well as to its preparation and use. This compound is outstandingly stable, and can be used as catalyst with excellent results.

Abstract: The invention relates to palladium(0)-tris{tri-[3,5-bis(trifluoromethyl)-phenyl]-phosphine} complex of formula (I), as well as to its preparation and use. This compound is outstandingly stable, and can be used as catalyst with excellent results.

Abstract: 3-substituted-6-trifluoromethyl pyridines are useful synthetic intermediates in the preparation of the N-substituted (6-haloalkylpyridin-3-yl)alkyl sulfoximines, which are useful in forming potent insecticides. Methods of forming such 3-substituted-6-trifluoromethyl pyridines are disclosed. Also disclosed are methods of using 6-trichloromethyl halogenated pyridines to form 3-substituted-6-trifluoromethyl pyridines are disclosed.

Abstract: A method of forming a fluorinated molecular entity includes reacting in a reaction mixture an aromatic halide, copper, a fluoroalkyl group, and a ligand. The aromatic halide includes an aromatic group and a halogen substituent bonded to the aromatic group. The ligand includes at least one group-V donor selected from phosphorus and an amine. The overall molar ratio of copper to aromatic halide in the reaction mixture is from 0.2 to 3. The method further includes forming a fluoroalkylarene including the aromatic group and the fluoroalkyl group bonded to the aromatic group. A composition, which may be used in the method, consists essentially of copper, the fluoroalkyl group, and the ligand, where the molar ratio of copper to the fluoroalkyl group is approximately 1.

Abstract: A complex of formula (1), wherein, M is palladium or nickel, R1 and R2 are independently organic groups having 1-20 carbon atoms, or R1 and R2 are linked to form a ring structure with the phosphorus atom, R3 is selected from the group consisting of substituted and unsubstituted aryl, substituted and unsubstituted heteroaryl, and substituted and unsubstituted metallocenyl, R4 is an organic group having 1-20 carbon atoms, n is 0, 1, 2, 3, 4 or 5, X is an anionic ligand. A process for the preparation of the complex, and its use in carbon-carbon or carbon-nitrogen coupling reactions is also provided.

Abstract: A salt represented by the formula (I): wherein Q1 and Q2 each independently represent a fluorine atom or a C1-C6 perfluoroalkyl group, L1 represents *—CO—O-La- or *—CH2—O-Lb-, * represents a binding position to —C(Q1)(Q2)-, La and Lb independently represent a C1-C15 divalent saturated hydrocarbon group in which one or more —CH2— can be replaced by —O— or —CO—, ring W1 represents a C2-C36 nitrogen-containing heterocyclic group in which one or more —CH2— can be replaced by —O—, and Z1? represents an organic counter ion.

Abstract: To provide a novel liquid crystal compound having general physical properties necessary for the compound, namely, stability to heat, light and so forth, a wide temperature range of a liquid crystal phase, a high clearing point, a good compatibility with other compounds, a large refractive index anisotropy, a large dielectric anisotropy and a small viscosity. The liquid crystal compound is provided as compound (1): wherein, for example, R1 is alkyl having 1 to 20 carbons; ring A1 and ring B1 are 1,4-cyclohexylene or 1,4-phenylene; Z1 and Z2 are a single bond, —CH2CH2—, —CH?CH— or —C?C—; L1 is fluorine; L2, Y1 and Y2 are hydrogen, fluorine or chlorine; and X1 is halogen, —C?N or alkyl having 1 to 10 carbons, and in the alkyl, arbitrary —CH2— may be replaced by —O— or —S—, and m is 1 and n is 0.

Abstract: The present invention relates to novel substituted enaminocarbonyl compounds, to processes for their preparation and to their use for controlling animal pests, especially arthropods, in particular insects.

Abstract: A sulfonic acid onium salt represented by the following formula (1) can be used as a superior radiosensitive acid generator for resist compositions. It is possible to form a good pattern by using a resist composition containing this sulfonic acid onium salt. In formula (1), R1 represents a monovalent organic group, and Q+ represents a sulfonium cation or iodonium cation.

Abstract: A process for the palladium-catalyzed coupling of terminal alkynes with heteroaryl tosylates and heteroaryl benzenesulfonates The present invention relates to a process for the regioselective synthesis of compounds of the formula (I), wherein D, J and W have the meanings indicated in the claims. The present invention provides an efficient and general palladium-catalyzed coupling process of heteroaryl tosylates with terminal alkynes to a wide variety of substituted, multifunctional heteroaryl-1-alkynes of the formula I.

Abstract: The present invention relates to a process for the production of trifluoromethylated unsubstituted or substituted aryl or heteroaryl compounds which comprises reacting an unsubstituted or substituted aryl or heteroaryl halide with a trifluoroacetate of formula (I) or (II), wherein R1 is hydrogen or a C1-C5 alkyl group and M an alkali metal or an ammonium ion, in the presence of and an anorganic halogenide salt or a trifluoroacetacid salt as activator compound and a catalytic combination of a copper salt with a monodentate, bidentate or tridentate aromatic or aliphatic amine or pyridine ligand.

Abstract: Compositions and methods are disclosed for inhibiting semicarbazide-sensitive amine oxidase (SSAO), also known as vascular adhesion protein-1 (VAP-1). The compounds disclosed are amine-containing and amide-containing compounds. The compounds and compositions are useful for treatment of diseases, including inflammation, inflammatory diseases and autoimmune disorders.

Abstract: The present invention relates to liquid-crystalline compounds having at least three fluorine-substituted benzene rings, a terminal trifluoromethyl group and at least one —CF2O— bridge. The invention also relates to liquid-crystalline media prepared therewith and to liquid-crystal display devices (LC displays) containing these media.

Abstract: A fluorinated pyridinium cationic compound of formula (I) wherein, Rf is F(CF2)6(CH2CF2)m(CH2CH2)n—, m and n are each independently integers of 1 to 3, and R is H, C1 to C5 linear or branched alkyl, or C1 to C5 linear or branched alkoxy, having surfactant properties for lowering surface tension in an aqueous medium or solvent medium, and for use as a foaming agent.

Abstract: The present invention relates to a new method of cross-coupling aryl moieties comprising reacting an arylhalide with an arylboronic acid in the presence of a palladium compound and a compound comprising a di-alkylphosphine moiety.

Abstract: The present invention relates to a process of a process for producing a 2-halogeno-6-substituted-4-trifluoromethylpyridine. Specifically, the present invention provides a process for producing a 2-halogeno-6-substituted-4-trifluoromethylpyridine represented by the formula (I): in which X is a chlorine atom, a bromine atom, or an iodine atom; R is alkyl, alkenyl, alkynyl, phenyl which may be substituted with A, benzyl which may be substituted with A, or cycloalkyl; and A is alkyl, alkoxy, a fluorine atom, or a chlorine atom, which comprises allowing a 2,6-dihalogeno-4-trifluoromethylpyridine represented by the formula (II): in which X is defined above, and a Grignard reagent represented by the formula (III): RMgX, in which R and X are defined above, to react with each other in the presence of a solvent.

Abstract: Provided is a solid luminescent quinoline compound capable of emitting light in a crystalline state, capable of changing the luminescent color not requiring modification of molecular configuration and capable of emitting light in response to external pressure such as heat, physical pressure, etc. The quinoline compound is represented by the following general formula (1): wherein R1 may be the same or different, each representing any of CF3 or CF3CF2; R2 represents any of an amino group, an N,N-dimethylamino group, an N-phenylamino group, a carbazole group, an N-methylamino group or an N-methyl-N-phenylamino group.

Abstract: Organic compounds of formula I may be used in optoelectronic devices wherein R1 is, independently at each occurrence, a C1-C20 aliphatic radical, a C3-C20 aromatic radical, or a C3-C20 cycloaliphatic radical; R2 is, independently at each occurrence, a C1-C20 aliphatic radical, a C3-C20 aromatic radical, or a C3-C20 cycloaliphatic radical; a is, independently at each occurrence, an integer ranging from 0-4; b is, independently at each occurrence, an integer ranging from 0-3; Ar1 is a direct bond or heteroaryl, aryl, or alkyl or cycloalkyl; Ar2 is heteroaryl, aryl, or alkyl or cycloalkyl; c is 0, 1 or 2; and n is an integer ranging from 2-4.

Abstract: The invention relates to liquid-crystalline compounds of the formula I in which R1, R2, A1, A2, A3, A4, Z1, Z2, Z3, V, a, b and c have the meanings indicated in claim 1, and to liquid-crystalline media comprising at least one compound of the formula I and to electro-optical displays containing a liquid-crystalline medium of this type.

Abstract: The invention concerns novel ionic compounds with low melting point whereof the onium type cation having at least a heteroatom such as N, 0, S or P bearing the positive charge and whereof the anion includes, wholly or partially, at least an ion imidide such as (FXI0)N—(OX2F) wherein X1 and X2 are identical or different and comprise SO or PF, and their use as solvent in electrochemical devices. Said composition comprises a salt wherein the anionic charge is delocalised, and can be used, inter alia, as electrolyte.

Abstract: A fluorinated pyridinium cationic compound of formula (I) wherein, Rf is F(CF2)6(CH2CF2)m(CH2CH2)n—, m and n are each independently integers of 1 to 3, and R is H, C1 to C5 linear or branched alkyl, or C1 to C5 linear or branched alkoxy, having surfactant properties for lowering surface tension in an aqueous medium or solvent medium, and for use as a foaming agent.

Abstract: A composition comprising a fluorinated pyridinium cationic compound of formula (I) wherein Rf is R1(CH2CH2)n—, R1 is a C7 to C20 perfluoroalkyl group interrupted by at least one catenary oxygen atom, each oxygen bonded to two carbon atoms, n is an integer of 1 to 3, and R is H, C1 to C5 linear or branched alkyl, or C1 to C5 linear or branched alkoxy, having surfactant properties for lowering surface tension in an aqueous medium or solvent medium, and for use as a foaming agent.

Abstract: The present disclosure provides methods of synthesizing alkylating agents and methods of use.

Abstract: Provided are complexes of the formula: where R1 is H, R4, OR4, N(R4)2 or CHAr2; R2 is H, CnF2n+1, CnF2n+1 SO2, COOR4, or CN; R3 is H, CnF2n+1, CnF2n+1SO2, COOR4, or CN; R4 is the same or different at each occurrence and is H, alkyl, or aryl, or adjacent R4 groups can join together to form a 5- or 6-membered ring, or adjacent R4 groups can join together to form a 5- or 6-membered ring; or adjacent R4 groups can join together to form a multicyclic moiety; each Ar is independently an aryl group; L? is a polydentate ligand that is not a phenylpyridine, phenylpyrimidine, or phenylquinoline; L? is a monodentate ligand, and is not a phenylpyridine, and phenylpyrimidine, or phenylquinoline; m is 1, 2 or 3; n is an integer from 1 through 20; y is 0, 1 or 2; and z is 0 or an integer from 1 through 4; with the proviso that the compound is charge neutral and the iridium is hexacoordinate.

Abstract: A process for the palladium-catalyzed coupling of terminal alkynes with heteroaryl tosylates and heteroaryl benzenesulfonates The present invention relates to a process for the regioselective synthesis of compounds of the formula (I), wherein D, J and W have the meanings indicated in the claims. The present invention provides an efficient and general palladium-catalyzed coupling process of heteroaryl tosylates with terminal alkynes to a wide variety of substituted, multifunctional heteroaryl-1-alkynes of the formula I.

Abstract: The invention relates to 2-(pyridin-2-yl)-pyrimidine compounds of general formula (I) and their use for controlling pathogenic fungi and as plant protection products that, as an active constituent, contain compounds of this type: In general formula (I), k represents 0, 1, 2, 3; m represents 0, 1, 2, 3, 4 or 5; n represents 1, 2, 3, 4 or 5; R1, independent of one another, represents halogen, OH, CN, NO2, C1-C4 alkyl, C1-C4 alkyl halide, C1-C4 alkoxy, C1-C4 alkoxy halide, C2-C4 alkenyl, C2-C4 alkynyl, C3-C8 cycloalkyl, C1-C4 alkoxy-C1-C4 alkyl, amino, phenoxy, which is optionally substituted by halogen or C1-C4 alkyl, NHR, NR2, C(Ra)?N—ORb, S(?O)pA1 or C(?O)A2, or two radicals R1 bound to adjacent carbon atoms can, together, also represent a group —O-Alk-O—, wherein Alk represents a linear or branched C1-C4 alkylene, and 1, 2, 3 or 4 hydrogen atoms can also be replaced by halogen; R2 represents C1-C4 alkyl halide, C1-C4 alkoxy, C1-C4 alkoxy halide, hydroxy, halogen, CN or NO2; whereby R2 can also represent

Abstract: The subject invention relates to a process for the synthesis of highly active binary metal fluoride system for the fluorination of aromatic compounds. Fluorinated aromatic compounds are valuable synthons for the chemical synthesis of pharmaceutical drugs and novel polymers. Fluorobenzene is used to control carbon content in steel manufacturing, is an intermediate for pharmaceuticals, pesticides and other organic compounds. Fluorobenzene is typically produced by the reaction of aniline and sodium nitrite in the presence of hydrogen fluoride. The present invention relates to a process for the synthesis of highly active binary metal fluoride system consists of copper (II) fluoride and aluminum (III) fluoride for the fluorination of aromatic compounds in gas phase and recycling of the reagent, in situ, using O2 and HF.

Abstract: Organic compounds of formula I may be used in optoelectronic devices wherein R1 is, independently at each occurrence, a C1-C20 aliphatic radical, a C3-C20 aromatic radical, or a C3-C20 cycloaliphatic radical; R2 is, independently at each occurrence, a C1-C20 aliphatic radical, a C3-C20 aromatic radical, or a C3-C20 cycloaliphatic radical; a is, independently at each occurrence, an integer ranging from 0-4; b is, independently at each occurrence, an integer ranging from 0-3; Ar1 is a direct bond or heteroaryl, aryl, or alkyl or cycloalkyl; Ar2 is heteroaryl, aryl, or alkyl or cycloalkyl; c is 0, 1 or 2; and n is an integer ranging from 2-4.

Abstract: The invention relates to compounds for selectively inhibiting human corticosteroid syntheses CYP11B1 and CYP11B2, to the production thereof and to their use for treating hypercortisolism and diabetes mellitus or insufficiency of the heart and myocardial fibrosis.

Abstract: The present application describes deuterium-enriched xaliproden, pharmaceutically acceptable salt forms thereof, and methods of treating using the same.

Abstract: A compound represented by formula (1): wherein R1 is hydrogen or alkyl having 1 to 20 carbons, in which in the alkyl, arbitrary —CH2— may be replaced by —O—, —S—, —COO—, —CH?CH— or —C?C—, and arbitrary hydrogen may be replaced by halogen or alkyl having 1 to 3 carbons; ring A1, ring A2, ring A3, ring A4 and ring A5 are each independently a benzene ring, a piperidine ring, a tetrahydropyrane ring or a dioxane ring, in which in the rings, arbitrary hydrogen may be replaced by halogen, alkyl having 1 to 3 carbons, alkoxy having 1 to 3 carbons or halogenated alkyl having 1 to 3 carbons, and —CH? may be replaced by —N?; Z1, Z2, Z4, Z5 and Z6 are each independently a single bond, —COO— or —CF2O—; Z3 is a single bond or —CF2O—, and in the case where Z3 is a single bond, ring A3 is a ring represented by formula (RG-5), or L1 and L2 are both fluorine, or at least one of Z1, Z2, Z4, Z5 and Z6 is —CF2O—; L1, L2, L3 and L4 are each independently hydrogen or halogen; X1 is hydrogen, halogen, —C?N, —N?C?S, —C?C—C?N, —S

Abstract: The present invention relates to a new method of cross-coupling aryl moieties comprising reacting an arylhalide with an arylboronic acid in the presence of a palladium compound and a compound comprising a di-alkylphosphine moiety.

Abstract: The present invention relates to a phenacylamine derivative of the formula (I) or a salt thereof: wherein A is alkyl, cycloalkyl, phenyl which may be substituted by Y, pyridyl which may be substituted by Y, or pyrazolyl which may be substituted by Y, R1 and R2 are each alkyl, or R1 and R2 may together form a 3- to 6-membered saturated carbocycle, R3 is hydrogen, alkyl, alkoxyalkyl, alkylthioalkyl or COR4, X is halogen, alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, haloalkynyl, alkoxy, haloalkoxy, alkenyloxy, haloalkenyloxy, alkynyloxy, haloalkynyloxy, alkylthio, haloalkylthio, alkenylthio, haloalkenylthio, alkynylthio, haloalkynylthio, alkylsulfinyl, haloalkylsulfinyl, alkylsulfonyl, haloalkylsulfonyl, dialkylaminosulfonyl, nitro, cyano, phenyl which may be substituted by Y, phenoxy which may be substituted by Y, benzyloxy which may be substituted by Y, or pyridyloxy which may be substituted by Y, and n is an integer of from 0 to 5.

Abstract: The invention relates to a microparticulate form of 1-[2-(2-naphthyl)-ethyl]-4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine hydrochloride consisting of particles for which at least 55% of the population have a diameter below 50 micrometers, and to pharmaceutical compositions in which it is present.

Abstract: The present invention relates to Halogenated amino acid analogues for use in diagnosis, which compounds have the general formula (I) wherein: R is (C1–C6) alkyl optionally substituted with thioether or ether oxygen atom when n=0, or a substituted aromatic or heteraromatic ring when n=1–6; and m=0 or 1; and X is a halogen atom.

Abstract: The present invention relates to a simple and efficient process for the preparation of amorphous form of torsemide. The process includes recovering amorphous torsemide from a solution thereof in a suitable solvent comprising alcohols, ketones, chlorinated hydrocarbons, esters, nitriles, cyclic ethers, and mixtures thereof, by spray drying.

Abstract: These compounds contain an oxetane functionality and a cinnamyl functionality. The oxetane functionality is homopolymerizable in reactions that can undergo cationic or anionic ring opening, and the cinnamyl functionality is polymerizable with compounds such as electron acceptor compounds. The dual functionality allows for dual cure processing. The generic structure of such compounds is in which R is a methyl or ethyl group, X and Y independently are a direct bond, or an ether, ester, or carbamate group, and Q is a divalent hydrocarbon (which may contain heteroatoms of N, O, or S), provided that X and Y will not both be direct bonds in the same molecule.

Abstract: The present invention provides processes useful in the preparation of certain ?3-adrenergic receptor agonists of the structural formula the pharmaceutically acceptable salts thereof, and the hydrates of said pharmaceutically acceptable salts, wherein HET is as described herein. The invention further provides intermediates useful in the preparation of such agonists, and processes useful in the production of such intermediates.

Abstract: To provide a practical method of manufacturing fluorine compounds in a small number of steps that can carry out fluorination reaction of substrates using easily available fluorinating agents that can be inexpensively produced industrially, and recover precursors of the fluorinating agents generated accompanying the reaction quantitatively in an easy operation, and a method of recovery and regeneration of the precursors of the fluorinating agents. N-Fluoro-quaternary-nitrogen-onium tetrafluoroborate salts represented by the general formula (1) as the fluorinating agents are used. N-Hydro-quaternary-nitrogen-onium tetrafluoroborate salts represented by the general formula (2) generated accompanying the reaction are separated and recovered from the reaction mixture by means of depositing as crystals by the addition of solvents with a low affinity to the salts to the reaction mixture after the reaction.

Abstract: A process for preparing a compound of the formula: wherein n, R1, R2, R3 and X are as defined above, used as an intermediate in the synthesis of ?-adrenergic receptor agonists.